Details of the Target

General Information of Target

Target ID LDTP06868
Target Name Angiomotin (AMOT)
Gene Name AMOT
Gene ID 154796
Synonyms
KIAA1071; Angiomotin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRNSEEQPSGGTTVLQRLLQEQLRYGNPSENRSLLAIHQQATGNGPPFPSGSGNPGPQSD
VLSPQDHHQQLVAHAARQEPQGQEIQSENLIMEKQLSPRMQNNEELPTYEEAKVQSQYFR
GQQHASVGAAFYVTGVTNQKMRTEGRPSVQRLNPGKMHQDEGLRDLKQGHVRSLSERLMQ
MSLATSGVKAHPPVTSAPLSPPQPNDLYKNPTSSSEFYKAQGPLPNQHSLKGMEHRGPPP
EYPFKGMPPQSVVCKPQEPGHFYSEHRLNQPGRTEGQLMRYQHPPEYGAARPAQDISLPL
SARNSQPHSPTSSLTSGGSLPLLQSPPSTRLSPARHPLVPNQGDHSAHLPRPQQHFLPNQ
AHQGDHYRLSQPGLSQQQQQQQQQHHHHHHHQQQQQQQPQQQPGEAYSAMPRAQPSSASY
QPVPADPFAIVSRAQQMVEILSDENRNLRQELEGCYEKVARLQKVETEIQRVSEAYENLV
KSSSKREALEKAMRNKLEGEIRRMHDFNRDLRERLETANKQLAEKEYEGSEDTRKTISQL
FAKNKESQREKEKLEAELATARSTNEDQRRHIEIRDQALSNAQAKVVKLEEELKKKQVYV
DKVEKMQQALVQLQAACEKREQLEHRLRTRLERELESLRIQQRQGNCQPTNVSEYNAAAL
MELLREKEERILALEADMTKWEQKYLEENVMRHFALDAAATVAAQRDTTVISHSPNTSYD
TALEARIQKEEEEILMANKRCLDMEGRIKTLHAQIIEKDAMIKVLQQRSRKEPSKTEQLS
CMRPAKSLMSISNAGSGLLSHSSTLTGSPIMEEKRDDKSWKGSLGILLGGDYRAEYVPST
PSPVPPSTPLLSAHSKTGSRDCSTQTERGTESNKTAAVAPISVPAPVAAAATAAAITATA
ATITTTMVAAAPVAVAAAAAPAAAAAPSPATAAATAAAVSPAAAGQIPAAASVASAAAVA
PSAAAAAAVQVAPAAPAPVPAPALVPVPAPAAAQASAPAQTQAPTSAPAVAPTPAPTPTP
AVAQAEVPASPATGPGPHRLSIPSLTCNPDKTDGPVFHSNTLERKTPIQILGQEPDAEMV
EYLI
Target Type
Literature-reported
Target Bioclass
Other
Family
Angiomotin family
Subcellular location
Cell junction, tight junction
Function
Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions.
TTD ID
T47510
Uniprot ID
Q4VCS5
DrugMap ID
TTI48OS
Ensemble ID
ENST00000304758.5
HGNC ID
HGNC:17810
ChEMBL ID
CHEMBL3392949

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A498 SNV: p.D206N .
AN3CA Deletion: p.S319PfsTer56 .
HEC1 SNV: p.Q392H .
HEC1B SNV: p.Q392H .
KYSE510 SNV: p.P284S .
LN18 SNV: p.Q65K .
LNCaP clone FGC SNV: p.Y655N .
MCC13 SNV: p.E444K
Substitution: p.P961F		 .
RH30 SNV: p.Q382E .
SW403 SNV: p.S952F .
WM2664 Insertion: p.Q614PfsTer5 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y281(20.00); Y832(14.99); Y719(14.64); Y599(12.30)  LDD0257  [1]
DA-P3
 Probe Info  		11.83  LDD0185  [2]
AHL-Pu-1
 Probe Info  		C647(2.23)  LDD0168  [3]
HHS-465
 Probe Info  		Y25(10.00); Y281(8.40); Y420(5.01); Y599(10.00)  LDD2237  [4]
DBIA
 Probe Info  		C455(1.70); C741(1.40); C1047(1.75)  LDD0080  [5]
ATP probe
 Probe Info  		K458(0.00); K156(0.00); K1051(0.00); K543(0.00)  LDD0199  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [7]
1d-yne
 Probe Info  		N.A.  LDD0356  [8]
ENE
 Probe Info  		C862(0.00); C1047(0.00); C781(0.00); C455(0.00)  LDD0006  [9]
IPM
 Probe Info  		C741(0.00); C1047(0.00); C617(0.00); C254(0.00)  LDD0005  [9]
NHS
 Probe Info  		K585(0.00); K543(0.00)  LDD0010  [9]
NPM
 Probe Info  		N.A.  LDD0016  [9]
PPMS
 Probe Info  		N.A.  LDD0008  [9]
SF
 Probe Info  		K596(0.00); Y719(0.00); Y599(0.00); Y287(0.00)  LDD0028  [10]
STPyne
 Probe Info  		K585(0.00); K520(0.00); K464(0.00); K481(0.00)  LDD0009  [9]
VSF
 Probe Info  		C455(0.00); C1047(0.00); C781(0.00); C862(0.00)  LDD0007  [9]
Phosphinate-6
 Probe Info  		C617(0.00); C781(0.00); C647(0.00); C254(0.00)  LDD0018  [11]
1c-yne
 Probe Info  		K464(0.00); K856(0.00); K1051(0.00); K684(0.00)  LDD0228  [8]
AOyne
 Probe Info  		11.50  LDD0443  [12]
PAL-AfBPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C112
 Probe Info  		18.00  LDD1799  [13]
C163
 Probe Info  		5.82  LDD1843  [13]
C177
 Probe Info  		9.06  LDD1856  [13]
C245
 Probe Info  		10.20  LDD1918  [13]
C246
 Probe Info  		13.45  LDD1919  [13]
C266
 Probe Info  		8.22  LDD1937  [13]
C285
 Probe Info  		24.08  LDD1955  [13]
C287
 Probe Info  		8.57  LDD1957  [13]
C338
 Probe Info  		11.55  LDD2001  [13]
C355
 Probe Info  		31.34  LDD2016  [13]
C391
 Probe Info  		13.18  LDD2050  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C647(2.23)  LDD0168  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C647(2.40)  LDD0372  [3]
 LDCM0214  AC1 HEK-293T C862(1.00); C741(0.96); C781(1.24); C455(1.07)  LDD1507  [14]
 LDCM0215  AC10 HEK-293T C862(0.94); C741(1.04); C781(0.99); C455(1.02)  LDD1508  [14]
 LDCM0226  AC11 HEK-293T C862(1.05); C741(0.98); C781(0.96); C455(0.89)  LDD1509  [14]
 LDCM0237  AC12 HEK-293T C862(1.04); C741(0.99); C781(1.01); C455(1.02)  LDD1510  [14]
 LDCM0259  AC14 HEK-293T C862(1.02); C741(1.04); C781(0.87); C455(1.08)  LDD1512  [14]
 LDCM0263  AC143 HEK-293T C862(0.82)  LDD0861  [5]
 LDCM0264  AC144 HEK-293T C862(1.09)  LDD0862  [5]
 LDCM0265  AC145 HEK-293T C862(1.33)  LDD0863  [5]
 LDCM0266  AC146 HEK-293T C862(1.16)  LDD0864  [5]
 LDCM0267  AC147 HEK-293T C862(1.02)  LDD0865  [5]
 LDCM0268  AC148 HEK-293T C862(1.08)  LDD0866  [5]
 LDCM0269  AC149 HEK-293T C862(0.66)  LDD0867  [5]
 LDCM0270  AC15 HEK-293T C862(1.01); C741(0.98); C781(0.98); C455(1.04)  LDD1513  [14]
 LDCM0271  AC150 HEK-293T C862(0.99)  LDD0869  [5]
 LDCM0272  AC151 HEK-293T C862(0.91)  LDD0870  [5]
 LDCM0273  AC152 HEK-293T C862(0.80)  LDD0871  [5]
 LDCM0274  AC153 HEK-293T C862(0.88)  LDD0872  [5]
 LDCM0621  AC154 HEK-293T C862(0.88)  LDD2162  [5]
 LDCM0622  AC155 HEK-293T C862(1.21)  LDD2163  [5]
 LDCM0623  AC156 HEK-293T C862(0.83)  LDD2164  [5]
 LDCM0624  AC157 HEK-293T C862(0.78)  LDD2165  [5]
 LDCM0276  AC17 HEK-293T C862(2.22)  LDD0874  [5]
 LDCM0277  AC18 HEK-293T C862(0.76)  LDD0875  [5]
 LDCM0278  AC19 HEK-293T C862(0.74)  LDD0876  [5]
 LDCM0279  AC2 HEK-293T C862(0.96); C741(0.97); C781(1.00); C455(1.03)  LDD1518  [14]
 LDCM0280  AC20 HEK-293T C862(0.92)  LDD0878  [5]
 LDCM0281  AC21 HEK-293T C862(0.75)  LDD0879  [5]
 LDCM0282  AC22 HEK-293T C862(0.86)  LDD0880  [5]
 LDCM0283  AC23 HEK-293T C862(0.79)  LDD0881  [5]
 LDCM0284  AC24 HEK-293T C862(0.85)  LDD0882  [5]
 LDCM0285  AC25 HEK-293T C862(0.59)  LDD0883  [5]
 LDCM0286  AC26 HEK-293T C862(0.87)  LDD0884  [5]
 LDCM0287  AC27 HEK-293T C862(0.96)  LDD0885  [5]
 LDCM0288  AC28 HEK-293T C862(1.12)  LDD0886  [5]
 LDCM0289  AC29 HEK-293T C862(0.77)  LDD0887  [5]
 LDCM0290  AC3 HEK-293T C862(0.99); C741(0.93); C781(1.05); C455(1.00)  LDD1529  [14]
 LDCM0291  AC30 HEK-293T C862(0.72)  LDD0889  [5]
 LDCM0292  AC31 HEK-293T C862(1.01)  LDD0890  [5]
 LDCM0293  AC32 HEK-293T C862(0.82)  LDD0891  [5]
 LDCM0294  AC33 HEK-293T C862(0.72)  LDD0892  [5]
 LDCM0295  AC34 HEK-293T C862(0.87)  LDD0893  [5]
 LDCM0296  AC35 HEK-293T C862(1.03); C741(0.96); C781(0.88); C455(0.92)  LDD1535  [14]
 LDCM0297  AC36 HEK-293T C862(0.91); C741(0.94); C781(1.01); C455(1.00)  LDD1536  [14]
 LDCM0298  AC37 HEK-293T C862(0.98); C741(1.03); C781(0.94); C455(1.06)  LDD1537  [14]
 LDCM0299  AC38 HEK-293T C862(0.93); C741(0.99); C781(0.91); C455(1.03)  LDD1538  [14]
 LDCM0300  AC39 HEK-293T C862(1.01); C741(1.02); C781(0.99); C455(1.09)  LDD1539  [14]
 LDCM0301  AC4 HEK-293T C862(0.98); C741(0.92); C781(1.09); C455(1.04)  LDD1540  [14]
 LDCM0302  AC40 HEK-293T C862(0.99); C741(0.99); C781(0.86); C455(1.00)  LDD1541  [14]
 LDCM0303  AC41 HEK-293T C862(1.08); C741(1.03); C781(1.07); C455(1.08)  LDD1542  [14]
 LDCM0304  AC42 HEK-293T C862(1.03); C741(1.00); C781(1.04); C455(1.01)  LDD1543  [14]
 LDCM0305  AC43 HEK-293T C862(0.98); C741(0.94); C781(0.91); C455(1.00)  LDD1544  [14]
 LDCM0306  AC44 HEK-293T C862(1.02); C741(0.94); C781(1.01); C455(1.11)  LDD1545  [14]
 LDCM0307  AC45 HEK-293T C862(1.04); C741(1.02); C781(0.99); C455(1.10)  LDD1546  [14]
 LDCM0308  AC46 HEK-293T C862(1.01); C741(0.96); C781(1.00); C455(1.01)  LDD1547  [14]
 LDCM0309  AC47 HEK-293T C862(0.99); C741(0.94); C781(1.00); C455(1.07)  LDD1548  [14]
 LDCM0310  AC48 HEK-293T C862(1.01); C741(1.02); C781(0.97); C455(1.03)  LDD1549  [14]
 LDCM0311  AC49 HEK-293T C862(1.02); C741(1.01); C781(1.14); C455(1.07)  LDD1550  [14]
 LDCM0312  AC5 HEK-293T C862(0.95); C741(1.03); C781(1.07); C455(0.98)  LDD1551  [14]
 LDCM0313  AC50 HEK-293T C862(0.96); C741(0.98); C781(1.03); C455(0.98)  LDD1552  [14]
 LDCM0314  AC51 HEK-293T C862(1.01); C741(0.97); C781(1.03); C455(1.01)  LDD1553  [14]
 LDCM0315  AC52 HEK-293T C862(1.02); C741(0.95); C781(1.02); C455(1.07)  LDD1554  [14]
 LDCM0316  AC53 HEK-293T C862(0.95); C741(1.04); C781(1.01); C455(1.09)  LDD1555  [14]
 LDCM0317  AC54 HEK-293T C862(0.98); C741(1.06); C781(0.98); C455(1.03)  LDD1556  [14]
 LDCM0318  AC55 HEK-293T C862(1.00); C741(1.02); C781(0.98); C455(1.07)  LDD1557  [14]
 LDCM0319  AC56 HEK-293T C862(1.03); C741(0.97); C781(0.98); C455(1.00)  LDD1558  [14]
 LDCM0320  AC57 HEK-293T C862(1.26)  LDD0918  [5]
 LDCM0321  AC58 HEK-293T C862(1.53)  LDD0919  [5]
 LDCM0322  AC59 HEK-293T C862(0.99)  LDD0920  [5]
 LDCM0323  AC6 HEK-293T C862(1.02); C741(0.95); C781(1.07); C455(1.01)  LDD1562  [14]
 LDCM0324  AC60 HEK-293T C862(0.80)  LDD0922  [5]
 LDCM0325  AC61 HEK-293T C862(0.98)  LDD0923  [5]
 LDCM0326  AC62 HEK-293T C862(0.70)  LDD0924  [5]
 LDCM0327  AC63 HEK-293T C862(1.15)  LDD0925  [5]
 LDCM0328  AC64 HEK-293T C862(0.82)  LDD0926  [5]
 LDCM0329  AC65 HEK-293T C862(1.02)  LDD0927  [5]
 LDCM0330  AC66 HEK-293T C862(0.75)  LDD0928  [5]
 LDCM0331  AC67 HEK-293T C862(0.99)  LDD0929  [5]
 LDCM0332  AC68 HEK-293T C862(0.69)  LDD0930  [5]
 LDCM0333  AC69 HEK-293T C862(0.82)  LDD0931  [5]
 LDCM0334  AC7 HEK-293T C862(1.01); C741(0.99); C781(1.02); C455(1.12)  LDD1568  [14]
 LDCM0335  AC70 HEK-293T C862(0.56)  LDD0933  [5]
 LDCM0336  AC71 HEK-293T C862(0.77)  LDD0934  [5]
 LDCM0337  AC72 HEK-293T C862(0.88)  LDD0935  [5]
 LDCM0338  AC73 HEK-293T C862(0.65)  LDD0936  [5]
 LDCM0339  AC74 HEK-293T C862(0.71)  LDD0937  [5]
 LDCM0340  AC75 HEK-293T C862(0.69)  LDD0938  [5]
 LDCM0341  AC76 HEK-293T C862(0.83)  LDD0939  [5]
 LDCM0342  AC77 HEK-293T C862(0.80)  LDD0940  [5]
 LDCM0343  AC78 HEK-293T C862(1.10)  LDD0941  [5]
 LDCM0344  AC79 HEK-293T C862(0.60)  LDD0942  [5]
 LDCM0345  AC8 HEK-293T C862(0.96); C741(0.97); C781(0.96); C455(1.09)  LDD1569  [14]
 LDCM0346  AC80 HEK-293T C862(0.75)  LDD0944  [5]
 LDCM0347  AC81 HEK-293T C862(0.72)  LDD0945  [5]
 LDCM0348  AC82 HEK-293T C862(0.80)  LDD0946  [5]
 LDCM0349  AC83 HEK-293T C862(1.06)  LDD0947  [5]
 LDCM0350  AC84 HEK-293T C862(1.38)  LDD0948  [5]
 LDCM0351  AC85 HEK-293T C862(1.27)  LDD0949  [5]
 LDCM0352  AC86 HEK-293T C862(1.21)  LDD0950  [5]
 LDCM0353  AC87 HEK-293T C862(1.00)  LDD0951  [5]
 LDCM0354  AC88 HEK-293T C862(1.28)  LDD0952  [5]
 LDCM0355  AC89 HEK-293T C862(1.35)  LDD0953  [5]
 LDCM0357  AC90 HEK-293T C862(1.65)  LDD0955  [5]
 LDCM0358  AC91 HEK-293T C862(1.19)  LDD0956  [5]
 LDCM0359  AC92 HEK-293T C862(1.29)  LDD0957  [5]
 LDCM0360  AC93 HEK-293T C862(1.05)  LDD0958  [5]
 LDCM0361  AC94 HEK-293T C862(1.04)  LDD0959  [5]
 LDCM0362  AC95 HEK-293T C862(1.04)  LDD0960  [5]
 LDCM0363  AC96 HEK-293T C862(1.26)  LDD0961  [5]
 LDCM0364  AC97 HEK-293T C862(1.16)  LDD0962  [5]
 LDCM0248  AKOS034007472 HEK-293T C862(0.99); C741(1.09); C781(0.99); C455(1.01)  LDD1511  [14]
 LDCM0356  AKOS034007680 HEK-293T C862(1.05); C741(1.00); C781(1.08); C455(1.06)  LDD1570  [14]
 LDCM0275  AKOS034007705 HEK-293T C862(1.01); C741(0.96); C781(0.98); C455(0.96)  LDD1514  [14]
 LDCM0087  Capsaicin HEK-293T 11.83  LDD0185  [2]
 LDCM0367  CL1 HEK-293T C862(0.91); C741(0.95); C781(1.02); C455(1.00)  LDD1571  [14]
 LDCM0368  CL10 HEK-293T C862(0.77); C741(0.86); C781(0.67); C455(1.10)  LDD1572  [14]
 LDCM0369  CL100 HEK-293T C862(0.94); C741(0.93); C781(1.10); C455(1.06)  LDD1573  [14]
 LDCM0370  CL101 HEK-293T C862(1.01); C741(0.96); C781(1.10); C455(1.08)  LDD1574  [14]
 LDCM0371  CL102 HEK-293T C862(1.02); C741(0.96); C781(1.02); C455(1.01)  LDD1575  [14]
 LDCM0372  CL103 HEK-293T C862(0.97); C741(1.04); C781(0.94); C455(1.04)  LDD1576  [14]
 LDCM0373  CL104 HEK-293T C862(0.97); C741(0.97); C781(1.05); C455(0.92)  LDD1577  [14]
 LDCM0374  CL105 HEK-293T C862(1.19)  LDD0972  [5]
 LDCM0375  CL106 HEK-293T C862(1.14)  LDD0973  [5]
 LDCM0376  CL107 HEK-293T C862(1.15)  LDD0974  [5]
 LDCM0377  CL108 HEK-293T C862(0.77)  LDD0975  [5]
 LDCM0378  CL109 HEK-293T C862(0.90)  LDD0976  [5]
 LDCM0379  CL11 HEK-293T C862(0.97); C741(0.92); C781(0.82); C455(1.23)  LDD1583  [14]
 LDCM0380  CL110 HEK-293T C862(0.62)  LDD0978  [5]
 LDCM0381  CL111 HEK-293T C862(0.95)  LDD0979  [5]
 LDCM0382  CL112 HEK-293T C862(0.60)  LDD0980  [5]
 LDCM0383  CL113 HEK-293T C862(0.67)  LDD0981  [5]
 LDCM0384  CL114 HEK-293T C862(0.65)  LDD0982  [5]
 LDCM0385  CL115 HEK-293T C862(0.96)  LDD0983  [5]
 LDCM0386  CL116 HEK-293T C862(0.85)  LDD0984  [5]
 LDCM0387  CL117 HEK-293T C862(0.99); C741(0.99); C781(1.16); C455(1.16)  LDD1591  [14]
 LDCM0388  CL118 HEK-293T C862(1.03); C741(1.06); C781(1.12); C455(1.03)  LDD1592  [14]
 LDCM0389  CL119 HEK-293T C862(1.02); C741(1.02); C781(0.99); C455(1.10)  LDD1593  [14]
 LDCM0390  CL12 HEK-293T C862(0.98); C741(0.94); C781(0.67); C455(1.00)  LDD1594  [14]
 LDCM0391  CL120 HEK-293T C862(1.01); C741(0.99); C781(1.05); C455(0.98)  LDD1595  [14]
 LDCM0392  CL121 HEK-293T C862(0.97); C741(1.02); C781(1.10); C455(1.10)  LDD1596  [14]
 LDCM0393  CL122 HEK-293T C862(0.95); C741(0.98); C781(1.07); C455(1.02)  LDD1597  [14]
 LDCM0394  CL123 HEK-293T C862(0.85); C741(0.93); C781(1.04); C455(0.97)  LDD1598  [14]
 LDCM0395  CL124 HEK-293T C862(0.96); C741(0.94); C781(1.18); C455(1.03)  LDD1599  [14]
 LDCM0396  CL125 HEK-293T C862(1.25)  LDD0994  [5]
 LDCM0397  CL126 HEK-293T C862(0.91)  LDD0995  [5]
 LDCM0398  CL127 HEK-293T C862(1.20)  LDD0996  [5]
 LDCM0399  CL128 HEK-293T C862(0.70)  LDD0997  [5]
 LDCM0400  CL13 HEK-293T C862(0.97); C741(1.06); C781(1.23); C455(1.06)  LDD1604  [14]
 LDCM0401  CL14 HEK-293T C862(1.01); C741(0.94); C781(1.09); C455(0.96)  LDD1605  [14]
 LDCM0402  CL15 HEK-293T C862(0.89); C741(1.23); C781(0.92); C455(1.01)  LDD1606  [14]
 LDCM0403  CL16 HEK-293T C862(0.96); C741(1.02); C781(0.88); C455(1.10)  LDD1607  [14]
 LDCM0404  CL17 HEK-293T C862(0.94); C741(1.05); C781(0.95); C455(1.03)  LDD1608  [14]
 LDCM0405  CL18 HEK-293T C862(0.95); C741(1.04); C781(0.81); C455(1.03)  LDD1609  [14]
 LDCM0406  CL19 HEK-293T C862(1.02); C741(1.08); C781(0.62); C455(0.97)  LDD1610  [14]
 LDCM0407  CL2 HEK-293T C862(0.99); C741(0.87); C781(1.10); C455(0.99)  LDD1611  [14]
 LDCM0408  CL20 HEK-293T C862(1.07); C741(1.08); C781(0.91); C455(1.19)  LDD1612  [14]
 LDCM0409  CL21 HEK-293T C862(0.94); C741(1.09); C781(0.52); C455(1.05)  LDD1613  [14]
 LDCM0410  CL22 HEK-293T C862(1.00); C741(0.95); C781(0.62); C455(1.10)  LDD1614  [14]
 LDCM0411  CL23 HEK-293T C862(1.05); C741(0.97); C781(0.80); C455(1.23)  LDD1615  [14]
 LDCM0412  CL24 HEK-293T C862(0.98); C741(1.02); C781(0.68); C455(1.07)  LDD1616  [14]
 LDCM0413  CL25 HEK-293T C862(0.88); C741(0.87); C781(1.15); C455(1.08)  LDD1617  [14]
 LDCM0414  CL26 HEK-293T C862(0.98); C741(0.94); C781(0.92); C455(0.96)  LDD1618  [14]
 LDCM0415  CL27 HEK-293T C862(0.95); C741(1.07); C781(0.93); C455(1.08)  LDD1619  [14]
 LDCM0416  CL28 HEK-293T C862(1.01); C741(0.98); C781(0.97); C455(1.05)  LDD1620  [14]
 LDCM0417  CL29 HEK-293T C862(1.10); C741(1.03); C781(0.89); C455(1.13)  LDD1621  [14]
 LDCM0418  CL3 HEK-293T C862(0.93); C741(1.07); C781(0.90); C455(1.07)  LDD1622  [14]
 LDCM0419  CL30 HEK-293T C862(1.00); C741(1.03); C781(0.77); C455(1.03)  LDD1623  [14]
 LDCM0420  CL31 HEK-293T C862(1.04); C741(1.06); C781(0.71); C455(0.96)  LDD1624  [14]
 LDCM0421  CL32 HEK-293T C862(1.06); C741(1.04); C781(0.95); C455(1.13)  LDD1625  [14]
 LDCM0422  CL33 HEK-293T C862(0.88); C741(1.08); C781(0.53); C455(0.93)  LDD1626  [14]
 LDCM0423  CL34 HEK-293T C862(1.00); C741(1.03); C781(0.63); C455(1.12)  LDD1627  [14]
 LDCM0424  CL35 HEK-293T C862(1.10); C741(1.05); C781(0.77); C455(1.17)  LDD1628  [14]
 LDCM0425  CL36 HEK-293T C862(1.03); C741(0.98); C781(0.69); C455(1.05)  LDD1629  [14]
 LDCM0426  CL37 HEK-293T C862(0.90); C741(0.91); C781(1.10); C455(0.99)  LDD1630  [14]
 LDCM0428  CL39 HEK-293T C862(0.97); C741(0.91); C781(0.94); C455(1.09)  LDD1632  [14]
 LDCM0429  CL4 HEK-293T C862(0.95); C741(1.01); C781(0.94); C455(1.11)  LDD1633  [14]
 LDCM0430  CL40 HEK-293T C862(1.08); C741(1.02); C781(0.91); C455(1.05)  LDD1634  [14]
 LDCM0431  CL41 HEK-293T C862(1.04); C741(1.03); C781(0.92); C455(1.05)  LDD1635  [14]
 LDCM0432  CL42 HEK-293T C862(1.06); C741(1.00); C781(0.83); C455(1.08)  LDD1636  [14]
 LDCM0433  CL43 HEK-293T C862(1.05); C741(1.01); C781(0.64); C455(1.10)  LDD1637  [14]
 LDCM0434  CL44 HEK-293T C862(1.13); C741(1.03); C781(0.87); C455(1.14)  LDD1638  [14]
 LDCM0435  CL45 HEK-293T C862(1.02); C741(1.01); C781(0.59); C455(1.11)  LDD1639  [14]
 LDCM0436  CL46 HEK-293T C862(1.07); C741(1.03); C781(0.61); C455(1.07)  LDD1640  [14]
 LDCM0437  CL47 HEK-293T C862(1.08); C741(0.99); C781(0.79); C455(1.22)  LDD1641  [14]
 LDCM0438  CL48 HEK-293T C862(1.07); C741(0.96); C781(0.75); C455(0.95)  LDD1642  [14]
 LDCM0439  CL49 HEK-293T C862(0.93); C741(0.94); C781(1.17); C455(0.97)  LDD1643  [14]
 LDCM0440  CL5 HEK-293T C862(1.00); C741(1.00); C781(1.04); C455(1.00)  LDD1644  [14]
 LDCM0441  CL50 HEK-293T C862(0.98); C741(0.92); C781(0.96); C455(1.03)  LDD1645  [14]
 LDCM0443  CL52 HEK-293T C862(1.01); C741(0.96); C781(0.91); C455(1.02)  LDD1646  [14]
 LDCM0444  CL53 HEK-293T C862(0.95); C741(1.03); C781(0.98); C455(1.07)  LDD1647  [14]
 LDCM0445  CL54 HEK-293T C862(0.92); C741(1.00); C781(0.82); C455(0.98)  LDD1648  [14]
 LDCM0446  CL55 HEK-293T C862(1.08); C741(1.02); C781(0.61); C455(1.05)  LDD1649  [14]
 LDCM0447  CL56 HEK-293T C862(1.06); C741(1.01); C781(0.89); C455(1.10)  LDD1650  [14]
 LDCM0448  CL57 HEK-293T C862(1.02); C741(1.17); C781(0.64); C455(1.25)  LDD1651  [14]
 LDCM0449  CL58 HEK-293T C862(1.03); C741(1.02); C781(0.63); C455(1.07)  LDD1652  [14]
 LDCM0450  CL59 HEK-293T C862(1.05); C741(0.95); C781(0.82); C455(1.16)  LDD1653  [14]
 LDCM0451  CL6 HEK-293T C862(0.89); C741(0.91); C781(0.89); C455(0.74)  LDD1654  [14]
 LDCM0452  CL60 HEK-293T C862(1.00); C741(0.97); C781(0.70); C455(0.98)  LDD1655  [14]
 LDCM0453  CL61 HEK-293T C862(0.88)  LDD1051  [5]
 LDCM0454  CL62 HEK-293T C862(1.10)  LDD1052  [5]
 LDCM0455  CL63 HEK-293T C862(0.67)  LDD1053  [5]
 LDCM0456  CL64 HEK-293T C862(1.43)  LDD1054  [5]
 LDCM0457  CL65 HEK-293T C862(0.93)  LDD1055  [5]
 LDCM0458  CL66 HEK-293T C862(1.04)  LDD1056  [5]
 LDCM0459  CL67 HEK-293T C862(0.61)  LDD1057  [5]
 LDCM0460  CL68 HEK-293T C862(0.60)  LDD1058  [5]
 LDCM0461  CL69 HEK-293T C862(0.87)  LDD1059  [5]
 LDCM0462  CL7 HEK-293T C862(0.98); C741(1.02); C781(0.66); C455(1.04)  LDD1665  [14]
 LDCM0463  CL70 HEK-293T C862(1.22)  LDD1061  [5]
 LDCM0464  CL71 HEK-293T C862(1.42)  LDD1062  [5]
 LDCM0465  CL72 HEK-293T C862(0.98)  LDD1063  [5]
 LDCM0466  CL73 HEK-293T C862(0.58)  LDD1064  [5]
 LDCM0467  CL74 HEK-293T C862(0.87)  LDD1065  [5]
 LDCM0469  CL76 HEK-293T C862(0.82)  LDD1067  [5]
 LDCM0470  CL77 HEK-293T C862(0.67)  LDD1068  [5]
 LDCM0471  CL78 HEK-293T C862(0.71)  LDD1069  [5]
 LDCM0472  CL79 HEK-293T C862(0.89)  LDD1070  [5]
 LDCM0473  CL8 HEK-293T C862(0.81); C741(1.03); C781(1.17); C455(1.09)  LDD1676  [14]
 LDCM0474  CL80 HEK-293T C862(1.33)  LDD1072  [5]
 LDCM0475  CL81 HEK-293T C862(0.68)  LDD1073  [5]
 LDCM0476  CL82 HEK-293T C862(0.73)  LDD1074  [5]
 LDCM0477  CL83 HEK-293T C862(0.53)  LDD1075  [5]
 LDCM0478  CL84 HEK-293T C862(0.73)  LDD1076  [5]
 LDCM0479  CL85 HEK-293T C862(0.94)  LDD1077  [5]
 LDCM0480  CL86 HEK-293T C862(1.04)  LDD1078  [5]
 LDCM0481  CL87 HEK-293T C862(0.70)  LDD1079  [5]
 LDCM0482  CL88 HEK-293T C862(1.14)  LDD1080  [5]
 LDCM0483  CL89 HEK-293T C862(1.06)  LDD1081  [5]
 LDCM0484  CL9 HEK-293T C862(0.91); C741(1.09); C781(0.53); C455(0.99)  LDD1687  [14]
 LDCM0485  CL90 HEK-293T C862(0.66)  LDD1083  [5]
 LDCM0486  CL91 HEK-293T C862(1.02); C741(0.96); C781(0.86); C455(1.07)  LDD1689  [14]
 LDCM0487  CL92 HEK-293T C862(0.98); C741(0.97); C781(0.99); C455(1.06)  LDD1690  [14]
 LDCM0488  CL93 HEK-293T C862(0.94); C741(1.06); C781(0.69); C455(1.18)  LDD1691  [14]
 LDCM0489  CL94 HEK-293T C862(1.00); C741(0.88); C781(0.77); C455(1.03)  LDD1692  [14]
 LDCM0490  CL95 HEK-293T C862(0.95); C741(1.06); C781(0.91); C455(1.08)  LDD1693  [14]
 LDCM0491  CL96 HEK-293T C862(0.98); C741(0.80); C781(0.95); C455(0.82)  LDD1694  [14]
 LDCM0492  CL97 HEK-293T C862(0.95); C741(0.95); C781(1.18); C455(1.02)  LDD1695  [14]
 LDCM0493  CL98 HEK-293T C862(0.99); C741(0.91); C781(1.05); C455(1.00)  LDD1696  [14]
 LDCM0494  CL99 HEK-293T C862(0.95); C741(0.89); C781(1.09); C455(1.01)  LDD1697  [14]
 LDCM0495  E2913 HEK-293T C862(0.98); C741(0.87); C781(0.98); C455(1.11)  LDD1698  [14]
 LDCM0468  Fragment33 HEK-293T C862(0.60)  LDD1066  [5]
 LDCM0427  Fragment51 HEK-293T C862(1.04); C741(0.96); C781(0.92); C455(1.03)  LDD1631  [14]
 LDCM0022  KB02 HCT 116 C455(1.70); C741(1.40); C1047(1.75)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C455(1.71); C741(1.27); C1047(0.99)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C455(2.40); C741(1.77); C1047(1.59)  LDD0082  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Serine/threonine-protein phosphatase 2A activator (PTPA) PTPA-type PPIase family Q15257
Septin-1 (SEPTIN1) Septin GTPase family Q8WYJ6
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) . Q13526
Other
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cytoskeletal 15 (KRT15) Intermediate filament family P19012
Mediator of RNA polymerase II transcription subunit 4 (MED4) Mediator complex subunit 4 family Q9NPJ6
Protein unc-119 homolog A (UNC119) PDE6D/unc-119 family Q13432
UPF0500 protein C1orf216 (C1orf216) UPF0500 family Q8TAB5
Leucine rich adaptor protein 1 (LURAP1) . Q96LR2
LIM domain transcription factor LMO4 (LMO4) . P61968
Merlin (NF2) . P35240
NF-kappa-B essential modulator (IKBKG) . Q9Y6K9
Rho GTPase-activating protein 17 (ARHGAP17) . Q68EM7
snRNA-activating protein complex subunit 5 (SNAPC5) . O75971

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
11 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402