Details of the Target

General Information of Target

Target ID LDTP14910
Target Name MAP7 domain-containing protein 1 (MAP7D1)
Gene Name MAP7D1
Gene ID 55700
Synonyms
KIAA1187; PARCC1; RPRC1; MAP7 domain-containing protein 1; Arginine/proline-rich coiled-coil domain-containing protein 1; Proline/arginine-rich coiled-coil domain-containing protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGPPSACPHRECIPWQGLLLTASLLTFWNAPTTAWLFIASAPFEVAEGENVHLSVVYLPE
NLYSYGWYKGKTVEPNQLIAAYVIDTHVRTPGPAYSGRETISPSGDLHFQNVTLEDTGYY
NLQVTYRNSQIEQASHHLRVYESVAQPSIQASSTTVTEKGSVVLTCHTNNTGTSFQWIFN
NQRLQVTKRMKLSWFNHVLTIDPIRQEDAGEYQCEVSNPVSSNRSDPLKLTVKSDDNTLG
ILIGVLVGSLLVAALVCFLLLRKTGRASDQSDFREQQPPASTPGHGPSDSSIS
Target Bioclass
Other
Family
MAP7 family
Subcellular location
Cytoplasm, cytoskeleton, spindle
Uniprot ID
Q3KQU3
Ensemble ID
ENST00000316156.8
HGNC ID
HGNC:25514

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 26 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
DA-P2
 Probe Info  		5.05  LDD0348  [2]
STPyne
 Probe Info  		K221(4.83)  LDD0277  [3]
BTD
 Probe Info  		C361(0.90)  LDD2089  [4]
DA-P3
 Probe Info  		10.30  LDD0179  [2]
AHL-Pu-1
 Probe Info  		C382(2.34)  LDD0168  [5]
Acrolein
 Probe Info  		N.A.  LDD0224  [6]
DBIA
 Probe Info  		C382(0.97); C251(0.95)  LDD0078  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C382(0.00); C373(0.00); C361(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		C251(0.00); C373(0.00); C361(0.00)  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		C251(0.00); C373(0.00); C361(0.00); C328(0.00)  LDD0037  [8]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [9]
NAIA_4
 Probe Info  		C328(0.00); C251(0.00); C373(0.00)  LDD2226  [10]
TFBX
 Probe Info  		C373(0.00); C251(0.00); C361(0.00)  LDD0027  [9]
WYneN
 Probe Info  		C361(0.00); C251(0.00); C373(0.00)  LDD0021  [11]
WYneO
 Probe Info  		N.A.  LDD0022  [11]
Compound 10
 Probe Info  		C251(0.00); C361(0.00); C373(0.00)  LDD2216  [12]
Compound 11
 Probe Info  		C251(0.00); C361(0.00); C373(0.00)  LDD2213  [12]
ENE
 Probe Info  		C361(0.00); C373(0.00); C251(0.00)  LDD0006  [11]
IPM
 Probe Info  		C361(0.00); C251(0.00); C373(0.00)  LDD0005  [11]
NPM
 Probe Info  		N.A.  LDD0016  [11]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [13]
Methacrolein
 Probe Info  		N.A.  LDD0218  [6]
W1
 Probe Info  		N.A.  LDD0236  [14]
AOyne
 Probe Info  		12.80  LDD0443  [15]
NAIA_5
 Probe Info  		C251(0.00); C361(0.00)  LDD2223  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C373(1.01)  LDD2117  [4]
 LDCM0025  4SU-RNA HEK-293T C382(2.34)  LDD0168  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C382(4.05); C373(2.95); C361(2.38); C328(2.53)  LDD0169  [5]
 LDCM0214  AC1 HEK-293T C373(1.03); C251(1.11); C382(1.07)  LDD1507  [16]
 LDCM0215  AC10 PaTu 8988t C373(1.45)  LDD1094  [7]
 LDCM0216  AC100 HCT 116 C373(0.74)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C373(0.67)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C373(0.65)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C373(1.26)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C373(0.90)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C373(0.73)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C373(1.11)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C373(0.91)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C373(0.69)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C373(0.85)  LDD0542  [7]
 LDCM0226  AC11 PaTu 8988t C373(1.28)  LDD1105  [7]
 LDCM0227  AC110 HCT 116 C373(0.71)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C373(0.75)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C373(0.84)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C373(1.20)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C373(1.63)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C373(1.89)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C373(1.92)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C373(1.71)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C373(1.17)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C373(1.60)  LDD0553  [7]
 LDCM0237  AC12 PaTu 8988t C373(1.49)  LDD1116  [7]
 LDCM0238  AC120 HCT 116 C373(1.07)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C373(1.18)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C373(1.39)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C373(1.24)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C373(1.68)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C373(1.66)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C373(2.62)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C373(1.97)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C373(0.78)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C373(0.99)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C373(0.84)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C373(0.67)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C373(0.60)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C373(0.85)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C373(0.82)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C373(0.62)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C373(0.75)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C373(0.56)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C373(0.50)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C373(0.76)  LDD0575  [7]
 LDCM0259  AC14 PaTu 8988t C373(2.27)  LDD1138  [7]
 LDCM0260  AC140 HCT 116 C373(0.71)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C373(0.70)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C373(0.68)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C373(0.97)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C373(1.71)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C373(1.01)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C373(1.26)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C373(1.15)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C373(1.63)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C373(1.32)  LDD0586  [7]
 LDCM0270  AC15 PaTu 8988t C373(1.63)  LDD1149  [7]
 LDCM0271  AC150 HCT 116 C373(0.94)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C373(1.01)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C373(1.39)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C373(2.91)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C373(1.61)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C373(1.71)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C373(1.32)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C373(1.46)  LDD2161  [7]
 LDCM0276  AC17 PaTu 8988t C373(0.86)  LDD1155  [7]
 LDCM0277  AC18 PaTu 8988t C373(1.12)  LDD1156  [7]
 LDCM0278  AC19 PaTu 8988t C373(1.08)  LDD1157  [7]
 LDCM0279  AC2 HEK-293T C361(0.97); C373(1.00); C251(1.07); C382(1.04)  LDD1518  [16]
 LDCM0280  AC20 PaTu 8988t C373(1.90)  LDD1159  [7]
 LDCM0281  AC21 PaTu 8988t C373(1.27)  LDD1160  [7]
 LDCM0282  AC22 PaTu 8988t C373(1.64)  LDD1161  [7]
 LDCM0283  AC23 PaTu 8988t C373(1.95)  LDD1162  [7]
 LDCM0284  AC24 PaTu 8988t C373(1.66)  LDD1163  [7]
 LDCM0285  AC25 HEK-293T C373(1.08); C251(1.22); C382(1.15)  LDD1524  [16]
 LDCM0286  AC26 HEK-293T C361(1.17); C373(1.03); C251(1.05); C382(1.09)  LDD1525  [16]
 LDCM0287  AC27 HEK-293T C373(1.03); C251(1.10); C382(1.05)  LDD1526  [16]
 LDCM0288  AC28 HEK-293T C361(1.22); C373(1.05); C251(1.19); C382(1.10)  LDD1527  [16]
 LDCM0289  AC29 HEK-293T C361(1.05); C373(1.00); C251(1.04)  LDD1528  [16]
 LDCM0290  AC3 HEK-293T C373(1.03); C251(1.02); C382(1.02)  LDD1529  [16]
 LDCM0291  AC30 HEK-293T C373(1.06); C251(1.00); C382(1.11)  LDD1530  [16]
 LDCM0292  AC31 HEK-293T C361(0.83); C373(1.04); C251(1.06)  LDD1531  [16]
 LDCM0293  AC32 HEK-293T C373(1.00); C251(1.20); C382(1.06)  LDD1532  [16]
 LDCM0294  AC33 HEK-293T C373(1.07); C251(1.17); C382(1.18)  LDD1533  [16]
 LDCM0295  AC34 HEK-293T C361(1.38); C373(1.03); C251(1.04); C382(1.07)  LDD1534  [16]
 LDCM0296  AC35 HEK-293T C373(0.99); C251(1.10); C382(1.02)  LDD1535  [16]
 LDCM0297  AC36 HEK-293T C361(0.89); C373(1.02); C251(1.12); C382(1.06)  LDD1536  [16]
 LDCM0298  AC37 HEK-293T C361(1.07); C373(1.05); C251(1.01)  LDD1537  [16]
 LDCM0299  AC38 HEK-293T C373(1.08); C251(1.06); C382(1.10)  LDD1538  [16]
 LDCM0300  AC39 HEK-293T C361(0.77); C373(1.09); C251(1.03)  LDD1539  [16]
 LDCM0301  AC4 HEK-293T C361(1.00); C373(1.02); C251(1.13); C382(1.15)  LDD1540  [16]
 LDCM0302  AC40 HEK-293T C373(1.08); C251(1.10); C382(1.03)  LDD1541  [16]
 LDCM0303  AC41 HEK-293T C373(1.05); C251(1.19); C382(1.19)  LDD1542  [16]
 LDCM0304  AC42 HEK-293T C361(1.31); C373(1.03); C251(1.14); C382(1.11)  LDD1543  [16]
 LDCM0305  AC43 HEK-293T C373(1.12); C251(1.09); C382(1.10)  LDD1544  [16]
 LDCM0306  AC44 HEK-293T C361(1.25); C373(1.09); C251(1.16); C382(1.11)  LDD1545  [16]
 LDCM0307  AC45 HEK-293T C361(0.84); C373(1.06); C251(1.07)  LDD1546  [16]
 LDCM0308  AC46 HEK-293T C373(1.07); C251(1.11); C382(1.13)  LDD1547  [16]
 LDCM0309  AC47 HEK-293T C361(0.74); C373(1.04); C251(1.09)  LDD1548  [16]
 LDCM0310  AC48 HEK-293T C373(1.03); C251(1.24); C382(1.09)  LDD1549  [16]
 LDCM0311  AC49 HEK-293T C373(1.06); C251(1.25); C382(1.17)  LDD1550  [16]
 LDCM0312  AC5 HEK-293T C361(1.45); C373(1.02); C251(1.02)  LDD1551  [16]
 LDCM0313  AC50 HEK-293T C361(1.34); C373(1.02); C251(1.07); C382(1.13)  LDD1552  [16]
 LDCM0314  AC51 HEK-293T C373(1.10); C251(1.08); C382(1.05)  LDD1553  [16]
 LDCM0315  AC52 HEK-293T C361(0.82); C373(0.99); C251(1.24); C382(1.17)  LDD1554  [16]
 LDCM0316  AC53 HEK-293T C361(0.85); C373(1.03); C251(1.03)  LDD1555  [16]
 LDCM0317  AC54 HEK-293T C373(1.09); C251(1.16); C382(1.08)  LDD1556  [16]
 LDCM0318  AC55 HEK-293T C361(0.92); C373(1.09); C251(1.08)  LDD1557  [16]
 LDCM0319  AC56 HEK-293T C373(1.01); C251(1.15); C382(1.08)  LDD1558  [16]
 LDCM0320  AC57 HCT 116 C373(20.00)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C373(2.36)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C373(2.08)  LDD0639  [7]
 LDCM0323  AC6 PaTu 8988t C373(0.98)  LDD1202  [7]
 LDCM0324  AC60 HCT 116 C373(1.28)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C373(20.00)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C373(2.23)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C373(2.45)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C373(1.58)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C373(0.25)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C373(0.33)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C373(0.28)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C373(1.05)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C373(1.47)  LDD0650  [7]
 LDCM0334  AC7 PaTu 8988t C373(0.97)  LDD1213  [7]
 LDCM0335  AC70 HCT 116 C373(0.93)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C373(0.78)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C373(1.59)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C373(1.66)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C373(1.72)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C373(2.79)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C373(1.31)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C373(1.46)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C373(1.22)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C373(1.18)  LDD0661  [7]
 LDCM0345  AC8 PaTu 8988t C373(1.23)  LDD1224  [7]
 LDCM0346  AC80 HCT 116 C373(1.91)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C373(1.72)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C373(2.06)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C373(1.76)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C373(1.54)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C373(1.04)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C373(1.43)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C373(1.70)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C373(1.88)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C373(2.16)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C373(0.81)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C373(2.93)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C373(2.72)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C373(1.83)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C373(1.79)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C373(2.52)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C373(2.41)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C373(3.86)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C373(1.58)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C373(0.76)  LDD0683  [7]
 LDCM0248  AKOS034007472 PaTu 8988t C373(1.57)  LDD1127  [7]
 LDCM0356  AKOS034007680 PaTu 8988t C373(0.93)  LDD1235  [7]
 LDCM0275  AKOS034007705 PaTu 8988t C373(1.49)  LDD1154  [7]
 LDCM0020  ARS-1620 HCC44 C382(0.97); C251(0.95)  LDD0078  [7]
 LDCM0087  Capsaicin HEK-293T 5.32  LDD0185  [2]
 LDCM0630  CCW28-3 231MFP C373(1.11)  LDD2214  [17]
 LDCM0632  CL-Sc Hep-G2 C361(20.00)  LDD2227  [10]
 LDCM0367  CL1 HEK-293T C361(1.23); C373(1.14); C251(1.01); C382(0.99)  LDD1571  [16]
 LDCM0368  CL10 HEK-293T C373(1.01); C251(1.28); C382(0.98)  LDD1572  [16]
 LDCM0369  CL100 HEK-293T C361(0.83); C373(0.93); C251(1.04); C382(1.02)  LDD1573  [16]
 LDCM0370  CL101 PaTu 8988t C373(0.87)  LDD1249  [7]
 LDCM0371  CL102 PaTu 8988t C373(0.93)  LDD1250  [7]
 LDCM0372  CL103 PaTu 8988t C373(2.02)  LDD1251  [7]
 LDCM0373  CL104 PaTu 8988t C373(1.11)  LDD1252  [7]
 LDCM0374  CL105 PaTu 8988t C373(1.16)  LDD1253  [7]
 LDCM0375  CL106 PaTu 8988t C373(1.00)  LDD1254  [7]
 LDCM0376  CL107 PaTu 8988t C373(1.96)  LDD1255  [7]
 LDCM0377  CL108 PaTu 8988t C373(1.59)  LDD1256  [7]
 LDCM0378  CL109 PaTu 8988t C373(1.20)  LDD1257  [7]
 LDCM0379  CL11 HEK-293T C361(0.91); C373(1.14); C251(1.05)  LDD1583  [16]
 LDCM0380  CL110 PaTu 8988t C373(1.59)  LDD1259  [7]
 LDCM0381  CL111 PaTu 8988t C373(1.84)  LDD1260  [7]
 LDCM0382  CL112 HEK-293T C361(0.90); C373(1.06); C251(1.31); C382(1.05)  LDD1586  [16]
 LDCM0383  CL113 HEK-293T C361(0.93); C373(1.03); C251(1.07); C382(1.11)  LDD1587  [16]
 LDCM0384  CL114 HEK-293T C361(1.02); C373(1.02); C251(1.08); C382(0.95)  LDD1588  [16]
 LDCM0385  CL115 HEK-293T C361(0.96); C373(1.06); C251(1.09); C382(1.16)  LDD1589  [16]
 LDCM0386  CL116 HEK-293T C361(0.70); C373(1.04); C251(0.94); C382(1.04)  LDD1590  [16]
 LDCM0387  CL117 HEK-293T C361(0.85); C373(1.03); C251(1.04); C382(1.12)  LDD1591  [16]
 LDCM0388  CL118 HEK-293T C361(1.38); C373(1.08); C251(1.20); C382(1.17)  LDD1592  [16]
 LDCM0389  CL119 HEK-293T C361(0.97); C373(1.12); C251(0.95); C382(1.15)  LDD1593  [16]
 LDCM0390  CL12 HEK-293T C373(1.08); C251(1.20); C382(0.94)  LDD1594  [16]
 LDCM0391  CL120 HEK-293T C361(0.81); C373(1.10); C251(1.36); C382(1.14)  LDD1595  [16]
 LDCM0392  CL121 HEK-293T C361(1.08); C373(1.08); C251(1.04); C382(1.09)  LDD1596  [16]
 LDCM0393  CL122 HEK-293T C361(0.97); C373(1.12); C251(1.05); C382(1.03)  LDD1597  [16]
 LDCM0394  CL123 HEK-293T C361(0.96); C373(1.00); C251(1.13); C382(1.03)  LDD1598  [16]
 LDCM0395  CL124 HEK-293T C361(0.74); C373(1.01); C251(1.19); C382(1.05)  LDD1599  [16]
 LDCM0396  CL125 HCT 116 C373(1.94)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C373(1.55)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C373(0.75)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C373(1.30)  LDD0716  [7]
 LDCM0400  CL13 HEK-293T C361(1.22); C373(1.20); C251(1.09); C382(1.22)  LDD1604  [16]
 LDCM0401  CL14 HEK-293T C361(0.87); C373(1.14); C251(1.00); C382(0.95)  LDD1605  [16]
 LDCM0402  CL15 HEK-293T C361(0.97); C373(1.14); C251(1.18); C382(1.08)  LDD1606  [16]
 LDCM0403  CL16 HEK-293T C361(0.77); C373(1.07); C251(1.35); C382(0.97)  LDD1607  [16]
 LDCM0404  CL17 HEK-293T C373(0.98); C251(1.26); C382(1.06)  LDD1608  [16]
 LDCM0405  CL18 HEK-293T C361(1.36); C373(1.09); C251(1.12); C382(1.08)  LDD1609  [16]
 LDCM0406  CL19 HEK-293T C373(1.15); C251(1.09); C382(1.06)  LDD1610  [16]
 LDCM0407  CL2 HEK-293T C361(0.94); C373(1.02); C251(0.89); C382(0.91)  LDD1611  [16]
 LDCM0408  CL20 HEK-293T C361(0.84); C373(1.14); C251(1.22); C382(1.06)  LDD1612  [16]
 LDCM0409  CL21 HEK-293T C361(1.90); C373(1.09); C251(1.21)  LDD1613  [16]
 LDCM0410  CL22 HEK-293T C373(1.06); C251(1.16); C382(1.08)  LDD1614  [16]
 LDCM0411  CL23 HEK-293T C361(1.07); C373(1.16); C251(1.07)  LDD1615  [16]
 LDCM0412  CL24 HEK-293T C373(1.06); C251(1.23); C382(0.96)  LDD1616  [16]
 LDCM0413  CL25 HEK-293T C361(0.81); C373(1.00); C251(1.09); C382(1.04)  LDD1617  [16]
 LDCM0414  CL26 HEK-293T C361(0.83); C373(1.01); C251(1.11); C382(0.99)  LDD1618  [16]
 LDCM0415  CL27 HEK-293T C361(1.06); C373(1.03); C251(1.00); C382(1.07)  LDD1619  [16]
 LDCM0416  CL28 HEK-293T C361(0.87); C373(0.99); C251(1.09); C382(1.06)  LDD1620  [16]
 LDCM0417  CL29 HEK-293T C373(0.99); C251(1.18); C382(1.08)  LDD1621  [16]
 LDCM0418  CL3 HEK-293T C361(1.06); C373(1.11); C251(1.16); C382(0.98)  LDD1622  [16]
 LDCM0419  CL30 HEK-293T C361(0.90); C373(1.04); C251(1.11); C382(1.04)  LDD1623  [16]
 LDCM0420  CL31 HEK-293T C373(1.15); C251(1.03); C382(1.09)  LDD1624  [16]
 LDCM0421  CL32 HEK-293T C361(1.30); C373(0.99); C251(1.30); C382(1.09)  LDD1625  [16]
 LDCM0422  CL33 HEK-293T C361(1.15); C373(0.98); C251(1.21)  LDD1626  [16]
 LDCM0423  CL34 HEK-293T C373(1.01); C251(1.19); C382(1.06)  LDD1627  [16]
 LDCM0424  CL35 HEK-293T C361(0.98); C373(1.09); C251(1.11)  LDD1628  [16]
 LDCM0425  CL36 HEK-293T C373(1.06); C251(1.18); C382(0.97)  LDD1629  [16]
 LDCM0426  CL37 HEK-293T C361(1.06); C373(1.03); C251(1.04); C382(1.04)  LDD1630  [16]
 LDCM0428  CL39 HEK-293T C361(1.07); C373(1.05); C251(1.12); C382(0.96)  LDD1632  [16]
 LDCM0429  CL4 HEK-293T C361(0.84); C373(0.98); C251(0.92); C382(0.94)  LDD1633  [16]
 LDCM0430  CL40 HEK-293T C361(0.93); C373(1.05); C251(1.10); C382(1.01)  LDD1634  [16]
 LDCM0431  CL41 HEK-293T C373(0.92); C251(1.16); C382(1.15)  LDD1635  [16]
 LDCM0432  CL42 HEK-293T C361(0.99); C373(0.99); C251(1.06); C382(0.99)  LDD1636  [16]
 LDCM0433  CL43 HEK-293T C373(1.03); C251(1.00); C382(1.01)  LDD1637  [16]
 LDCM0434  CL44 HEK-293T C361(1.29); C373(1.02); C251(1.28); C382(1.13)  LDD1638  [16]
 LDCM0435  CL45 HEK-293T C361(1.27); C373(1.14); C251(1.12)  LDD1639  [16]
 LDCM0436  CL46 HEK-293T C373(1.05); C251(1.09); C382(1.02)  LDD1640  [16]
 LDCM0437  CL47 HEK-293T C361(0.79); C373(1.16); C251(1.10)  LDD1641  [16]
 LDCM0438  CL48 HEK-293T C373(1.10); C251(1.14); C382(1.04)  LDD1642  [16]
 LDCM0439  CL49 HEK-293T C361(0.94); C373(1.02); C251(0.98); C382(0.99)  LDD1643  [16]
 LDCM0440  CL5 HEK-293T C373(1.00); C251(1.27); C382(0.95)  LDD1644  [16]
 LDCM0441  CL50 HEK-293T C361(0.70); C373(0.94); C251(1.24); C382(0.98)  LDD1645  [16]
 LDCM0443  CL52 HEK-293T C361(0.93); C373(0.94); C251(1.03); C382(1.07)  LDD1646  [16]
 LDCM0444  CL53 HEK-293T C373(1.12); C251(1.25); C382(1.10)  LDD1647  [16]
 LDCM0445  CL54 HEK-293T C361(0.78); C373(1.03); C251(1.22); C382(1.04)  LDD1648  [16]
 LDCM0446  CL55 HEK-293T C373(1.11); C251(1.09); C382(1.04)  LDD1649  [16]
 LDCM0447  CL56 HEK-293T C361(1.05); C373(1.05); C251(1.15); C382(1.09)  LDD1650  [16]
 LDCM0448  CL57 HEK-293T C361(1.73); C373(1.17); C251(1.15)  LDD1651  [16]
 LDCM0449  CL58 HEK-293T C373(1.03); C251(1.31); C382(1.11)  LDD1652  [16]
 LDCM0450  CL59 HEK-293T C361(0.86); C373(1.18); C251(1.13)  LDD1653  [16]
 LDCM0451  CL6 HEK-293T C361(1.10); C373(0.96); C251(1.17); C382(0.97)  LDD1654  [16]
 LDCM0452  CL60 HEK-293T C373(1.13); C251(1.14); C382(1.06)  LDD1655  [16]
 LDCM0453  CL61 HEK-293T C361(1.18); C373(1.16); C251(0.96); C382(1.02)  LDD1656  [16]
 LDCM0454  CL62 HEK-293T C361(1.11); C373(1.10); C251(1.06); C382(0.95)  LDD1657  [16]
 LDCM0455  CL63 HEK-293T C361(1.09); C373(1.06); C251(0.98); C382(1.09)  LDD1658  [16]
 LDCM0456  CL64 HEK-293T C361(0.75); C373(1.10); C251(1.32); C382(0.95)  LDD1659  [16]
 LDCM0457  CL65 HEK-293T C373(1.12); C251(1.17); C382(1.09)  LDD1660  [16]
 LDCM0458  CL66 HEK-293T C361(0.82); C373(1.03); C251(1.13); C382(1.04)  LDD1661  [16]
 LDCM0459  CL67 HEK-293T C373(1.07); C251(1.10); C382(1.04)  LDD1662  [16]
 LDCM0460  CL68 HEK-293T C361(0.85); C373(1.12); C251(1.11); C382(1.05)  LDD1663  [16]
 LDCM0461  CL69 HEK-293T C361(1.45); C373(1.08); C251(1.12)  LDD1664  [16]
 LDCM0462  CL7 HEK-293T C373(1.01); C251(1.07); C382(0.98)  LDD1665  [16]
 LDCM0463  CL70 HEK-293T C373(1.10); C251(1.15); C382(1.04)  LDD1666  [16]
 LDCM0464  CL71 HEK-293T C361(0.86); C373(1.13); C251(1.12)  LDD1667  [16]
 LDCM0465  CL72 HEK-293T C373(1.16); C251(1.28); C382(1.14)  LDD1668  [16]
 LDCM0466  CL73 HEK-293T C361(0.98); C373(1.02); C251(0.52); C382(1.11)  LDD1669  [16]
 LDCM0467  CL74 HEK-293T C361(0.73); C373(1.08); C251(1.02); C382(0.98)  LDD1670  [16]
 LDCM0469  CL76 HEK-293T C361(0.69); C373(1.06); C251(1.12); C382(1.01)  LDD1672  [16]
 LDCM0470  CL77 HEK-293T C373(0.98); C251(1.25); C382(1.18)  LDD1673  [16]
 LDCM0471  CL78 HEK-293T C361(1.27); C373(1.07); C251(1.07); C382(1.09)  LDD1674  [16]
 LDCM0472  CL79 HEK-293T C373(1.07); C251(1.01); C382(1.08)  LDD1675  [16]
 LDCM0473  CL8 HEK-293T C361(0.92); C373(0.92); C251(1.29); C382(0.92)  LDD1676  [16]
 LDCM0474  CL80 HEK-293T C361(1.17); C373(1.04); C251(1.22); C382(1.08)  LDD1677  [16]
 LDCM0475  CL81 HEK-293T C361(1.26); C373(1.18); C251(1.09)  LDD1678  [16]
 LDCM0476  CL82 HEK-293T C373(1.04); C251(1.07); C382(1.10)  LDD1679  [16]
 LDCM0477  CL83 HEK-293T C361(1.10); C373(1.00); C251(1.09)  LDD1680  [16]
 LDCM0478  CL84 HEK-293T C373(1.01); C251(1.19); C382(0.97)  LDD1681  [16]
 LDCM0479  CL85 HEK-293T C361(0.90); C373(1.04); C251(1.01); C382(1.09)  LDD1682  [16]
 LDCM0480  CL86 HEK-293T C361(0.53); C373(1.13); C251(1.02); C382(0.93)  LDD1683  [16]
 LDCM0481  CL87 HEK-293T C361(0.92); C373(1.10); C251(1.07); C382(1.02)  LDD1684  [16]
 LDCM0482  CL88 HEK-293T C361(0.72); C373(1.09); C251(1.18); C382(1.04)  LDD1685  [16]
 LDCM0483  CL89 HEK-293T C373(1.03); C251(1.21); C382(1.07)  LDD1686  [16]
 LDCM0484  CL9 HEK-293T C361(0.82); C373(1.08); C251(1.09)  LDD1687  [16]
 LDCM0485  CL90 HEK-293T C361(0.78); C373(1.13); C251(1.35); C382(1.00)  LDD1688  [16]
 LDCM0486  CL91 HEK-293T C373(1.09); C251(1.01); C382(0.99)  LDD1689  [16]
 LDCM0487  CL92 HEK-293T C361(0.98); C373(1.03); C251(1.20); C382(1.04)  LDD1690  [16]
 LDCM0488  CL93 HEK-293T C361(1.68); C373(1.05); C251(1.03)  LDD1691  [16]
 LDCM0489  CL94 HEK-293T C373(1.09); C251(1.16); C382(1.03)  LDD1692  [16]
 LDCM0490  CL95 HEK-293T C361(0.91); C373(1.07); C251(1.34)  LDD1693  [16]
 LDCM0491  CL96 HEK-293T C373(1.06); C251(1.13); C382(0.94)  LDD1694  [16]
 LDCM0492  CL97 HEK-293T C361(1.51); C373(0.96); C251(0.95); C382(1.14)  LDD1695  [16]
 LDCM0493  CL98 HEK-293T C361(0.82); C373(1.04); C251(1.04); C382(0.99)  LDD1696  [16]
 LDCM0494  CL99 HEK-293T C361(0.85); C373(1.00); C251(1.08); C382(0.97)  LDD1697  [16]
 LDCM0634  CY-0357 Hep-G2 C251(1.98); C373(1.80)  LDD2228  [10]
 LDCM0027  Dopamine HEK-293T 10.30  LDD0179  [2]
 LDCM0495  E2913 HEK-293T C361(0.98); C373(1.20); C251(0.97); C382(1.04)  LDD1698  [16]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C373(1.56); C361(1.47)  LDD1702  [4]
 LDCM0031  Epigallocatechin gallate HEK-293T 14.51  LDD0183  [2]
 LDCM0625  F8 Ramos C361(0.86); C373(1.06)  LDD2187  [18]
 LDCM0572  Fragment10 Ramos C373(1.18)  LDD2189  [18]
 LDCM0573  Fragment11 Ramos C373(0.85)  LDD2190  [18]
 LDCM0574  Fragment12 Ramos C361(1.88); C373(0.93)  LDD2191  [18]
 LDCM0575  Fragment13 Ramos C373(1.06)  LDD2192  [18]
 LDCM0576  Fragment14 Ramos C361(1.12); C373(1.22)  LDD2193  [18]
 LDCM0579  Fragment20 Ramos C373(1.59)  LDD2194  [18]
 LDCM0580  Fragment21 Ramos C361(1.04); C373(0.77)  LDD2195  [18]
 LDCM0582  Fragment23 Ramos C361(0.98); C373(0.95)  LDD2196  [18]
 LDCM0578  Fragment27 Ramos C361(1.05); C373(0.99)  LDD2197  [18]
 LDCM0586  Fragment28 Ramos C361(0.94); C373(5.95)  LDD2198  [18]
 LDCM0588  Fragment30 Ramos C361(1.04); C373(0.94)  LDD2199  [18]
 LDCM0589  Fragment31 Ramos C361(1.08); C373(0.83)  LDD2200  [18]
 LDCM0590  Fragment32 Ramos C373(1.54)  LDD2201  [18]
 LDCM0468  Fragment33 HEK-293T C361(1.00); C373(0.97); C251(1.07); C382(1.14)  LDD1671  [16]
 LDCM0596  Fragment38 Ramos C361(1.10); C373(0.51)  LDD2203  [18]
 LDCM0566  Fragment4 Ramos C373(1.28)  LDD2184  [18]
 LDCM0427  Fragment51 HEK-293T C361(1.03); C373(0.96); C251(1.05); C382(0.95)  LDD1631  [16]
 LDCM0610  Fragment52 Ramos C361(1.25); C373(2.80)  LDD2204  [18]
 LDCM0614  Fragment56 Ramos C361(1.41); C373(1.18)  LDD2205  [18]
 LDCM0569  Fragment7 Ramos C373(1.81)  LDD2186  [18]
 LDCM0571  Fragment9 Ramos C373(1.64)  LDD2188  [18]
 LDCM0022  KB02 HEK-293T C382(0.93); C361(0.89); C373(0.92); C251(1.01)  LDD1492  [16]
 LDCM0023  KB03 Jurkat C373(15.03); C328(32.39); C251(5.53)  LDD0209  [19]
 LDCM0024  KB05 G361 C251(4.49)  LDD3311  [20]
 LDCM0109  NEM HeLa N.A.  LDD0224  [6]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C361(0.90)  LDD2089  [4]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C361(0.99)  LDD2092  [4]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C361(0.97)  LDD2094  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C361(1.08)  LDD2099  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C361(1.02)  LDD2107  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C361(1.08)  LDD2109  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C373(0.95)  LDD2111  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C361(2.37)  LDD2119  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C361(0.79)  LDD2123  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C373(0.92)  LDD2125  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C361(1.05)  LDD2129  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C361(1.25)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C361(1.41)  LDD2136  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C361(0.78)  LDD2144  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C361(1.03)  LDD2146  [4]
 LDCM0029  Quercetin HEK-293T 17.00  LDD0181  [2]
 LDCM0170  Structure8 Ramos 8.04  LDD0433  [21]
 LDCM0021  THZ1 HCT 116 C382(1.12)  LDD2173  [7]
 LDCM0112  W16 Hep-G2 C373(0.67)  LDD0239  [14]

References

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2 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
13 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
14 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
15 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
16 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
17 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
18 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
19 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
20 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
21 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.