Details of the Target

General Information of Target

Target ID LDTP08888
Target Name Oxidation resistance protein 1 (OXR1)
Gene Name OXR1
Gene ID 55074
Synonyms
Oxidation resistance protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTKDKNSPGLKKKSQSVDINAPGFNPLAGAGKQTPQASKPPAPKTPIIEEEQNNAANTQK
HPSRRSELKRFYTIDTGQKKTLDKKDGRRMSFQKPKGTIEYTVESRDSLNSIALKFDTTP
NELVQLNKLFSRAVVTGQVLYVPDPEYVSSVESSPSLSPVSPLSPTSSEAEFDKTTNPDV
HPTEATPSSTFTGIRPARVVSSTSEEEEAFTEKFLKINCKYITSGKGTVSGVLLVTPNNI
MFDPHKNDPLVQENGCEEYGIMCPMEEVMSAAMYKEILDSKIKESLPIDIDQLSGRDFCH
SKKMTGSNTEEIDSRIRDAGNDSASTAPRSTEESLSEDVFTESELSPIREELVSSDELRQ
DKSSGASSESVQTVNQAEVESLTVKSESTGTPGHLRSDTEHSTNEVGTLCHKTDLNNLEM
AIKEDQIADNFQGISGPKEDSTSIKGNSDQDSFLHENSLHQEESQKENMPCGETAEFKQK
QSVNKGKQGKEQNQDSQTEAEELRKLWKTHTMQQTKQQRENIQQVSQKEAKHKITSADGH
IESSALLKEKQRHRLHKFLCLRVGKPMRKTFVSQASATMQQYAQRDKKHEYWFAVPQERT
DHLYAFFIQWSPEIYAEDTGEYTREPGFIVVKKIEESETIEDSSNQAAAREWEVVSVAEY
HRRIDALNTEELRTLCRRLQITTREDINSKQVATVKADLESESFRPNLSDPSELLLPDQI
EKLTKHLPPRTIGYPWTLVYGTGKHGTSLKTLYRTMTGLDTPVLMVIKDSDGQVFGALAS
EPLKVSDGFYGTGETFVFTFCPEFEVFKWTGDNMFFIKGDMDSLAFGGGGGEFALWLDGD
LYHGRSHSCKTFGNRTLSKKEDFFIQDIEIWAFE
Target Bioclass
Other
Family
OXR1 family
Subcellular location
Mitochondrion
Function May be involved in protection from oxidative damage.
Uniprot ID
Q8N573
Ensemble ID
ENST00000297447.10
HGNC ID
HGNC:15822
ChEMBL ID
CHEMBL4295901

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
DA-P3
 Probe Info  		7.08  LDD0181  [2]
AHL-Pu-1
 Probe Info  		C256(4.47)  LDD0170  [3]
DBIA
 Probe Info  		C471(1.47)  LDD0080  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [5]
NAIA_4
 Probe Info  		N.A.  LDD2226  [6]
IPM
 Probe Info  		C410(0.00); C471(0.00)  LDD2156  [7]
AOyne
 Probe Info  		13.30  LDD0443  [8]
NAIA_5
 Probe Info  		C299(0.00); C849(0.00)  LDD2223  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C256(4.47)  LDD0170  [3]
 LDCM0026  4SU-RNA+native RNA DM93 C256(3.11)  LDD0171  [3]
 LDCM0214  AC1 HCT 116 C471(1.16)  LDD0531  [4]
 LDCM0216  AC100 PaTu 8988t C471(1.20)  LDD1095  [4]
 LDCM0217  AC101 PaTu 8988t C471(1.04)  LDD1096  [4]
 LDCM0218  AC102 PaTu 8988t C471(1.19)  LDD1097  [4]
 LDCM0219  AC103 PaTu 8988t C471(1.08)  LDD1098  [4]
 LDCM0220  AC104 PaTu 8988t C471(1.16)  LDD1099  [4]
 LDCM0221  AC105 PaTu 8988t C471(1.13)  LDD1100  [4]
 LDCM0222  AC106 PaTu 8988t C471(1.34)  LDD1101  [4]
 LDCM0223  AC107 PaTu 8988t C471(1.10)  LDD1102  [4]
 LDCM0224  AC108 PaTu 8988t C471(1.15)  LDD1103  [4]
 LDCM0225  AC109 PaTu 8988t C471(1.33)  LDD1104  [4]
 LDCM0227  AC110 PaTu 8988t C471(1.22)  LDD1106  [4]
 LDCM0228  AC111 PaTu 8988t C471(1.63)  LDD1107  [4]
 LDCM0229  AC112 PaTu 8988t C471(1.21)  LDD1108  [4]
 LDCM0230  AC113 HCT 116 C471(1.05)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C471(0.75)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C471(0.88)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C471(1.02)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C471(1.01)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C471(0.91)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C471(0.99)  LDD0553  [4]
 LDCM0238  AC120 HCT 116 C471(1.03)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C471(0.66)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C471(0.80)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C471(0.69)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C471(0.96)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C471(0.82)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C471(0.91)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C471(0.86)  LDD0562  [4]
 LDCM0246  AC128 PaTu 8988t C471(1.36)  LDD1125  [4]
 LDCM0247  AC129 PaTu 8988t C471(1.26)  LDD1126  [4]
 LDCM0249  AC130 PaTu 8988t C471(1.08)  LDD1128  [4]
 LDCM0250  AC131 PaTu 8988t C471(0.99)  LDD1129  [4]
 LDCM0251  AC132 PaTu 8988t C471(1.12)  LDD1130  [4]
 LDCM0252  AC133 PaTu 8988t C471(1.20)  LDD1131  [4]
 LDCM0253  AC134 PaTu 8988t C471(1.07)  LDD1132  [4]
 LDCM0254  AC135 PaTu 8988t C471(1.35)  LDD1133  [4]
 LDCM0255  AC136 PaTu 8988t C471(1.33)  LDD1134  [4]
 LDCM0256  AC137 PaTu 8988t C471(1.34)  LDD1135  [4]
 LDCM0257  AC138 PaTu 8988t C471(1.24)  LDD1136  [4]
 LDCM0258  AC139 PaTu 8988t C471(1.27)  LDD1137  [4]
 LDCM0260  AC140 PaTu 8988t C471(1.51)  LDD1139  [4]
 LDCM0261  AC141 PaTu 8988t C471(1.21)  LDD1140  [4]
 LDCM0262  AC142 PaTu 8988t C471(1.24)  LDD1141  [4]
 LDCM0276  AC17 HCT 116 C471(1.01)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C471(0.85)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C471(1.01)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C471(1.16)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C471(1.05)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C471(1.00)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C471(0.98)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C471(0.94)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C471(1.00)  LDD0601  [4]
 LDCM0290  AC3 HCT 116 C471(1.10)  LDD0607  [4]
 LDCM0296  AC35 PaTu 8988t C471(1.21)  LDD1175  [4]
 LDCM0297  AC36 PaTu 8988t C471(1.59)  LDD1176  [4]
 LDCM0298  AC37 PaTu 8988t C471(1.35)  LDD1177  [4]
 LDCM0299  AC38 PaTu 8988t C471(1.39)  LDD1178  [4]
 LDCM0300  AC39 PaTu 8988t C471(1.85)  LDD1179  [4]
 LDCM0301  AC4 HCT 116 C471(1.13)  LDD0618  [4]
 LDCM0302  AC40 PaTu 8988t C471(1.78)  LDD1181  [4]
 LDCM0303  AC41 PaTu 8988t C471(1.14)  LDD1182  [4]
 LDCM0304  AC42 PaTu 8988t C471(1.20)  LDD1183  [4]
 LDCM0305  AC43 PaTu 8988t C471(1.38)  LDD1184  [4]
 LDCM0306  AC44 PaTu 8988t C471(1.45)  LDD1185  [4]
 LDCM0307  AC45 PaTu 8988t C471(1.34)  LDD1186  [4]
 LDCM0312  AC5 HCT 116 C471(1.24)  LDD0629  [4]
 LDCM0320  AC57 HCT 116 C471(0.92)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C471(0.87)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C471(1.09)  LDD0639  [4]
 LDCM0324  AC60 HCT 116 C471(1.19)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C471(0.84)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C471(0.88)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C471(1.12)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C471(1.19)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C471(0.97)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C471(0.88)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C471(1.06)  LDD0648  [4]
 LDCM0349  AC83 HCT 116 C471(1.21)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C471(1.27)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C471(1.39)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C471(1.10)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C471(1.11)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C471(1.06)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C471(1.20)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C471(1.19)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C471(1.24)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C471(1.29)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C471(1.31)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C471(1.67)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C471(1.43)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C471(1.49)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C471(1.72)  LDD0681  [4]
 LDCM0365  AC98 PaTu 8988t C471(1.12)  LDD1244  [4]
 LDCM0366  AC99 PaTu 8988t C471(1.10)  LDD1245  [4]
 LDCM0156  Aniline NCI-H1299 13.41  LDD0403  [1]
 LDCM0087  Capsaicin HEK-293T 5.58  LDD0185  [2]
 LDCM0632  CL-Sc Hep-G2 C299(20.00); C410(0.91)  LDD2227  [6]
 LDCM0367  CL1 PaTu 8988t C471(2.32)  LDD1246  [4]
 LDCM0368  CL10 PaTu 8988t C471(2.37)  LDD1247  [4]
 LDCM0369  CL100 HCT 116 C471(1.19)  LDD0686  [4]
 LDCM0374  CL105 HCT 116 C471(0.88)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C471(0.65)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C471(0.83)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C471(0.81)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C471(0.90)  LDD0695  [4]
 LDCM0379  CL11 PaTu 8988t C471(1.91)  LDD1258  [4]
 LDCM0380  CL110 HCT 116 C471(0.94)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C471(1.08)  LDD0698  [4]
 LDCM0387  CL117 PaTu 8988t C471(1.28)  LDD1266  [4]
 LDCM0388  CL118 PaTu 8988t C471(0.98)  LDD1267  [4]
 LDCM0389  CL119 PaTu 8988t C471(1.34)  LDD1268  [4]
 LDCM0390  CL12 PaTu 8988t C471(1.80)  LDD1269  [4]
 LDCM0391  CL120 PaTu 8988t C471(1.39)  LDD1270  [4]
 LDCM0396  CL125 HCT 116 C471(1.06)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C471(0.75)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C471(0.95)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C471(0.94)  LDD0716  [4]
 LDCM0400  CL13 PaTu 8988t C471(2.24)  LDD1279  [4]
 LDCM0401  CL14 PaTu 8988t C471(2.37)  LDD1280  [4]
 LDCM0402  CL15 PaTu 8988t C471(1.73)  LDD1281  [4]
 LDCM0403  CL16 PaTu 8988t C471(1.16)  LDD1282  [4]
 LDCM0404  CL17 HCT 116 C471(1.09)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C471(0.98)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C471(1.17)  LDD0723  [4]
 LDCM0407  CL2 PaTu 8988t C471(1.55)  LDD1286  [4]
 LDCM0408  CL20 HCT 116 C471(1.21)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C471(1.01)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C471(0.90)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C471(0.88)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C471(0.91)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C471(0.88)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C471(0.96)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C471(0.90)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C471(1.14)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C471(1.04)  LDD0734  [4]
 LDCM0418  CL3 PaTu 8988t C471(1.25)  LDD1297  [4]
 LDCM0419  CL30 HCT 116 C471(0.70)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C471(0.96)  LDD0737  [4]
 LDCM0429  CL4 PaTu 8988t C471(1.92)  LDD1308  [4]
 LDCM0436  CL46 HCT 116 C471(1.12)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C471(1.07)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C471(1.07)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C471(1.05)  LDD0756  [4]
 LDCM0440  CL5 PaTu 8988t C471(1.29)  LDD1319  [4]
 LDCM0441  CL50 HCT 116 C471(0.98)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C471(1.20)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C471(1.37)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C471(0.97)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C471(0.97)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C471(1.07)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C471(1.04)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C471(1.10)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C471(1.09)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C471(0.98)  LDD0767  [4]
 LDCM0451  CL6 PaTu 8988t C471(2.08)  LDD1330  [4]
 LDCM0452  CL60 HCT 116 C471(1.15)  LDD0769  [4]
 LDCM0462  CL7 PaTu 8988t C471(1.57)  LDD1341  [4]
 LDCM0469  CL76 HCT 116 C471(1.18)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C471(1.02)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C471(1.22)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C471(1.44)  LDD0789  [4]
 LDCM0473  CL8 PaTu 8988t C471(2.19)  LDD1352  [4]
 LDCM0474  CL80 HCT 116 C471(1.16)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C471(1.24)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C471(1.93)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C471(1.47)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C471(1.70)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C471(1.10)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C471(1.06)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C471(1.30)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C471(1.44)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C471(2.24)  LDD0800  [4]
 LDCM0484  CL9 PaTu 8988t C471(1.40)  LDD1363  [4]
 LDCM0485  CL90 HCT 116 C471(1.34)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C471(1.34)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C471(1.18)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C471(1.08)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C471(1.27)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C471(1.22)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C471(1.14)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C471(1.10)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C471(1.23)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C471(1.12)  LDD0811  [4]
 LDCM0634  CY-0357 Hep-G2 C410(0.89)  LDD2228  [6]
 LDCM0022  KB02 HCT 116 C471(1.47)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C471(1.09)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C471(1.45)  LDD0082  [4]
 LDCM0032  Oleacein HEK-293T 6.81  LDD0184  [2]
 LDCM0029  Quercetin HEK-293T 7.08  LDD0181  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Kelch-like ECH-associated protein 1 (KEAP1) KEAP1 family Q14145

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.