Details of the Target
General Information of Target
Target ID | LDTP07203 | |||||
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Target Name | ER membrane protein complex subunit 10 (EMC10) | |||||
Gene Name | EMC10 | |||||
Gene ID | 284361 | |||||
Synonyms |
C19orf63; INM02; ER membrane protein complex subunit 10; Hematopoietic signal peptide-containing membrane domain-containing protein 1 |
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3D Structure | ||||||
Sequence |
MAAASAGATRLLLLLLMAVAAPSRARGSGCRAGTGARGAGAEGREGEACGTVGLLLEHSF
EIDDSANFRKRGSLLWNQQDGTLSLSQRQLSEEERGRLRDVAALNGLYRVRIPRRPGALD GLEAGGYVSSFVPACSLVESHLSDQLTLHVDVAGNVVGVSVVTHPGGCRGHEVEDVDLEL FNTSVQLQPPTTAPGPETAAFIERLEMEQAQKAKNPQEQKSFFAKYWMYIIPVVLFLMMS GAPDTGGQGGGGGGGGGGGSGR |
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Target Bioclass |
Transporter and channel
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Family |
EMC10 family
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Subcellular location |
Secreted; Endoplasmic reticulum membrane
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Function |
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable). Promotes angiogenesis and tissue repair in the heart after myocardial infarction. Stimulates cardiac endothelial cell migration and outgrowth via the activation of p38 MAPK, PAK and MAPK2 signaling pathways.
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Uniprot ID | ||||||
Ensemble ID | ||||||
HGNC ID |
Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
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m-APA Probe Info |
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12.53 | LDD0402 | [1] | |
DA-P3 Probe Info |
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17.68 | LDD0179 | [2] | |
DBIA Probe Info |
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C49(1.09) | LDD1507 | [3] | |
IA-alkyne Probe Info |
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N.A. | LDD0165 | [4] | |
NAIA_4 Probe Info |
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N.A. | LDD2226 | [5] | |
Phosphinate-6 Probe Info |
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N.A. | LDD0018 | [6] | |
AOyne Probe Info |
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14.00 | LDD0443 | [7] | |
NAIA_5 Probe Info |
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N.A. | LDD2223 | [5] |
Competitor(s) Related to This Target
Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
---|---|---|---|---|---|
LDCM0214 | AC1 | HEK-293T | C49(1.09) | LDD1507 | [3] |
LDCM0215 | AC10 | HEK-293T | C49(0.98) | LDD1508 | [3] |
LDCM0226 | AC11 | HEK-293T | C49(1.10) | LDD1509 | [3] |
LDCM0237 | AC12 | HEK-293T | C49(0.96) | LDD1510 | [3] |
LDCM0259 | AC14 | HEK-293T | C49(1.05) | LDD1512 | [3] |
LDCM0270 | AC15 | HEK-293T | C49(0.96) | LDD1513 | [3] |
LDCM0276 | AC17 | HEK-293T | C49(0.97) | LDD1515 | [3] |
LDCM0277 | AC18 | HEK-293T | C49(0.95) | LDD1516 | [3] |
LDCM0278 | AC19 | HEK-293T | C49(1.60) | LDD1517 | [3] |
LDCM0279 | AC2 | HEK-293T | C49(0.94) | LDD1518 | [3] |
LDCM0280 | AC20 | HEK-293T | C49(0.89) | LDD1519 | [3] |
LDCM0281 | AC21 | HEK-293T | C49(1.02) | LDD1520 | [3] |
LDCM0282 | AC22 | HEK-293T | C49(1.04) | LDD1521 | [3] |
LDCM0283 | AC23 | HEK-293T | C49(0.93) | LDD1522 | [3] |
LDCM0284 | AC24 | HEK-293T | C49(1.00) | LDD1523 | [3] |
LDCM0285 | AC25 | HEK-293T | C49(1.03) | LDD1524 | [3] |
LDCM0286 | AC26 | HEK-293T | C49(0.92) | LDD1525 | [3] |
LDCM0287 | AC27 | HEK-293T | C49(1.12) | LDD1526 | [3] |
LDCM0288 | AC28 | HEK-293T | C49(1.02) | LDD1527 | [3] |
LDCM0289 | AC29 | HEK-293T | C49(1.02) | LDD1528 | [3] |
LDCM0290 | AC3 | HEK-293T | C49(1.00) | LDD1529 | [3] |
LDCM0291 | AC30 | HEK-293T | C49(1.16) | LDD1530 | [3] |
LDCM0292 | AC31 | HEK-293T | C49(0.99) | LDD1531 | [3] |
LDCM0293 | AC32 | HEK-293T | C49(0.93) | LDD1532 | [3] |
LDCM0294 | AC33 | HEK-293T | C49(1.02) | LDD1533 | [3] |
LDCM0295 | AC34 | HEK-293T | C49(1.10) | LDD1534 | [3] |
LDCM0296 | AC35 | HEK-293T | C49(1.14) | LDD1535 | [3] |
LDCM0297 | AC36 | HEK-293T | C49(0.97) | LDD1536 | [3] |
LDCM0298 | AC37 | HEK-293T | C49(0.95) | LDD1537 | [3] |
LDCM0299 | AC38 | HEK-293T | C49(1.21) | LDD1538 | [3] |
LDCM0300 | AC39 | HEK-293T | C49(0.98) | LDD1539 | [3] |
LDCM0301 | AC4 | HEK-293T | C49(1.00) | LDD1540 | [3] |
LDCM0302 | AC40 | HEK-293T | C49(0.98) | LDD1541 | [3] |
LDCM0303 | AC41 | HEK-293T | C49(1.00) | LDD1542 | [3] |
LDCM0304 | AC42 | HEK-293T | C49(1.04) | LDD1543 | [3] |
LDCM0305 | AC43 | HEK-293T | C49(1.00) | LDD1544 | [3] |
LDCM0306 | AC44 | HEK-293T | C49(1.00) | LDD1545 | [3] |
LDCM0307 | AC45 | HEK-293T | C49(1.01) | LDD1546 | [3] |
LDCM0308 | AC46 | HEK-293T | C49(1.08) | LDD1547 | [3] |
LDCM0309 | AC47 | HEK-293T | C49(1.02) | LDD1548 | [3] |
LDCM0310 | AC48 | HEK-293T | C49(0.99) | LDD1549 | [3] |
LDCM0311 | AC49 | HEK-293T | C49(1.12) | LDD1550 | [3] |
LDCM0312 | AC5 | HEK-293T | C49(0.95) | LDD1551 | [3] |
LDCM0313 | AC50 | HEK-293T | C49(0.97) | LDD1552 | [3] |
LDCM0314 | AC51 | HEK-293T | C49(1.04) | LDD1553 | [3] |
LDCM0315 | AC52 | HEK-293T | C49(0.98) | LDD1554 | [3] |
LDCM0316 | AC53 | HEK-293T | C49(1.01) | LDD1555 | [3] |
LDCM0317 | AC54 | HEK-293T | C49(1.02) | LDD1556 | [3] |
LDCM0318 | AC55 | HEK-293T | C49(1.09) | LDD1557 | [3] |
LDCM0319 | AC56 | HEK-293T | C49(0.99) | LDD1558 | [3] |
LDCM0320 | AC57 | HEK-293T | C49(1.05) | LDD1559 | [3] |
LDCM0321 | AC58 | HEK-293T | C49(1.05) | LDD1560 | [3] |
LDCM0322 | AC59 | HEK-293T | C49(1.11) | LDD1561 | [3] |
LDCM0323 | AC6 | HEK-293T | C49(0.96) | LDD1562 | [3] |
LDCM0324 | AC60 | HEK-293T | C49(1.04) | LDD1563 | [3] |
LDCM0325 | AC61 | HEK-293T | C49(1.07) | LDD1564 | [3] |
LDCM0326 | AC62 | HEK-293T | C49(0.90) | LDD1565 | [3] |
LDCM0327 | AC63 | HEK-293T | C49(1.02) | LDD1566 | [3] |
LDCM0328 | AC64 | HEK-293T | C49(0.94) | LDD1567 | [3] |
LDCM0334 | AC7 | HEK-293T | C49(0.97) | LDD1568 | [3] |
LDCM0345 | AC8 | HEK-293T | C49(1.10) | LDD1569 | [3] |
LDCM0248 | AKOS034007472 | HEK-293T | C49(0.94) | LDD1511 | [3] |
LDCM0356 | AKOS034007680 | HEK-293T | C49(1.03) | LDD1570 | [3] |
LDCM0275 | AKOS034007705 | HEK-293T | C49(1.09) | LDD1514 | [3] |
LDCM0087 | Capsaicin | HEK-293T | 4.38 | LDD0185 | [2] |
LDCM0367 | CL1 | HEK-293T | C49(1.12) | LDD1571 | [3] |
LDCM0368 | CL10 | HEK-293T | C49(1.14) | LDD1572 | [3] |
LDCM0369 | CL100 | HEK-293T | C49(0.85) | LDD1573 | [3] |
LDCM0370 | CL101 | HEK-293T | C49(1.00) | LDD1574 | [3] |
LDCM0371 | CL102 | HEK-293T | C49(1.00) | LDD1575 | [3] |
LDCM0372 | CL103 | HEK-293T | C49(0.94) | LDD1576 | [3] |
LDCM0373 | CL104 | HEK-293T | C49(1.02) | LDD1577 | [3] |
LDCM0374 | CL105 | HEK-293T | C49(0.99) | LDD1578 | [3] |
LDCM0375 | CL106 | HEK-293T | C49(1.14) | LDD1579 | [3] |
LDCM0376 | CL107 | HEK-293T | C49(0.91) | LDD1580 | [3] |
LDCM0377 | CL108 | HEK-293T | C49(1.08) | LDD1581 | [3] |
LDCM0378 | CL109 | HEK-293T | C49(0.99) | LDD1582 | [3] |
LDCM0379 | CL11 | HEK-293T | C49(0.75) | LDD1583 | [3] |
LDCM0380 | CL110 | HEK-293T | C49(1.10) | LDD1584 | [3] |
LDCM0381 | CL111 | HEK-293T | C49(0.91) | LDD1585 | [3] |
LDCM0382 | CL112 | HEK-293T | C49(0.99) | LDD1586 | [3] |
LDCM0383 | CL113 | HEK-293T | C49(1.02) | LDD1587 | [3] |
LDCM0384 | CL114 | HEK-293T | C49(1.09) | LDD1588 | [3] |
LDCM0385 | CL115 | HEK-293T | C49(0.99) | LDD1589 | [3] |
LDCM0386 | CL116 | HEK-293T | C49(1.02) | LDD1590 | [3] |
LDCM0387 | CL117 | HEK-293T | C49(0.95) | LDD1591 | [3] |
LDCM0388 | CL118 | HEK-293T | C49(1.21) | LDD1592 | [3] |
LDCM0389 | CL119 | HEK-293T | C49(1.02) | LDD1593 | [3] |
LDCM0390 | CL12 | HEK-293T | C49(1.10) | LDD1594 | [3] |
LDCM0391 | CL120 | HEK-293T | C49(0.98) | LDD1595 | [3] |
LDCM0392 | CL121 | HEK-293T | C49(0.97) | LDD1596 | [3] |
LDCM0393 | CL122 | HEK-293T | C49(1.09) | LDD1597 | [3] |
LDCM0394 | CL123 | HEK-293T | C49(1.01) | LDD1598 | [3] |
LDCM0395 | CL124 | HEK-293T | C49(1.08) | LDD1599 | [3] |
LDCM0396 | CL125 | HEK-293T | C49(0.99) | LDD1600 | [3] |
LDCM0397 | CL126 | HEK-293T | C49(1.12) | LDD1601 | [3] |
LDCM0398 | CL127 | HEK-293T | C49(1.22) | LDD1602 | [3] |
LDCM0399 | CL128 | HEK-293T | C49(1.02) | LDD1603 | [3] |
LDCM0400 | CL13 | HEK-293T | C49(1.20) | LDD1604 | [3] |
LDCM0401 | CL14 | HEK-293T | C49(1.14) | LDD1605 | [3] |
LDCM0402 | CL15 | HEK-293T | C49(0.96) | LDD1606 | [3] |
LDCM0403 | CL16 | HEK-293T | C49(1.08) | LDD1607 | [3] |
LDCM0404 | CL17 | HEK-293T | C49(0.98) | LDD1608 | [3] |
LDCM0405 | CL18 | HEK-293T | C49(0.87) | LDD1609 | [3] |
LDCM0406 | CL19 | HEK-293T | C49(1.15) | LDD1610 | [3] |
LDCM0407 | CL2 | HEK-293T | C49(1.04) | LDD1611 | [3] |
LDCM0408 | CL20 | HEK-293T | C49(0.54) | LDD1612 | [3] |
LDCM0409 | CL21 | HEK-293T | C49(1.00) | LDD1613 | [3] |
LDCM0410 | CL22 | HEK-293T | C49(1.13) | LDD1614 | [3] |
LDCM0411 | CL23 | HEK-293T | C49(0.70) | LDD1615 | [3] |
LDCM0412 | CL24 | HEK-293T | C49(1.14) | LDD1616 | [3] |
LDCM0413 | CL25 | HEK-293T | C49(0.94) | LDD1617 | [3] |
LDCM0414 | CL26 | HEK-293T | C49(1.05) | LDD1618 | [3] |
LDCM0415 | CL27 | HEK-293T | C49(0.86) | LDD1619 | [3] |
LDCM0416 | CL28 | HEK-293T | C49(0.95) | LDD1620 | [3] |
LDCM0417 | CL29 | HEK-293T | C49(0.87) | LDD1621 | [3] |
LDCM0418 | CL3 | HEK-293T | C49(0.85) | LDD1622 | [3] |
LDCM0419 | CL30 | HEK-293T | C49(0.81) | LDD1623 | [3] |
LDCM0420 | CL31 | HEK-293T | C49(1.05) | LDD1624 | [3] |
LDCM0421 | CL32 | HEK-293T | C49(0.60) | LDD1625 | [3] |
LDCM0422 | CL33 | HEK-293T | C49(1.08) | LDD1626 | [3] |
LDCM0423 | CL34 | HEK-293T | C49(1.00) | LDD1627 | [3] |
LDCM0424 | CL35 | HEK-293T | C49(0.61) | LDD1628 | [3] |
LDCM0425 | CL36 | HEK-293T | C49(1.01) | LDD1629 | [3] |
LDCM0426 | CL37 | HEK-293T | C49(0.86) | LDD1630 | [3] |
LDCM0428 | CL39 | HEK-293T | C49(0.85) | LDD1632 | [3] |
LDCM0429 | CL4 | HEK-293T | C49(1.14) | LDD1633 | [3] |
LDCM0430 | CL40 | HEK-293T | C49(0.97) | LDD1634 | [3] |
LDCM0431 | CL41 | HEK-293T | C49(0.91) | LDD1635 | [3] |
LDCM0432 | CL42 | HEK-293T | C49(0.90) | LDD1636 | [3] |
LDCM0433 | CL43 | HEK-293T | C49(1.06) | LDD1637 | [3] |
LDCM0434 | CL44 | HEK-293T | C49(0.62) | LDD1638 | [3] |
LDCM0435 | CL45 | HEK-293T | C49(1.10) | LDD1639 | [3] |
LDCM0436 | CL46 | HEK-293T | C49(1.03) | LDD1640 | [3] |
LDCM0437 | CL47 | HEK-293T | C49(0.66) | LDD1641 | [3] |
LDCM0438 | CL48 | HEK-293T | C49(1.03) | LDD1642 | [3] |
LDCM0439 | CL49 | HEK-293T | C49(0.90) | LDD1643 | [3] |
LDCM0440 | CL5 | HEK-293T | C49(1.05) | LDD1644 | [3] |
LDCM0441 | CL50 | HEK-293T | C49(1.04) | LDD1645 | [3] |
LDCM0443 | CL52 | HEK-293T | C49(1.23) | LDD1646 | [3] |
LDCM0444 | CL53 | HEK-293T | C49(0.94) | LDD1647 | [3] |
LDCM0445 | CL54 | HEK-293T | C49(0.87) | LDD1648 | [3] |
LDCM0446 | CL55 | HEK-293T | C49(1.21) | LDD1649 | [3] |
LDCM0447 | CL56 | HEK-293T | C49(0.61) | LDD1650 | [3] |
LDCM0448 | CL57 | HEK-293T | C49(1.19) | LDD1651 | [3] |
LDCM0449 | CL58 | HEK-293T | C49(1.32) | LDD1652 | [3] |
LDCM0450 | CL59 | HEK-293T | C49(0.75) | LDD1653 | [3] |
LDCM0451 | CL6 | HEK-293T | C49(0.95) | LDD1654 | [3] |
LDCM0452 | CL60 | HEK-293T | C49(1.09) | LDD1655 | [3] |
LDCM0453 | CL61 | HEK-293T | C49(0.93) | LDD1656 | [3] |
LDCM0454 | CL62 | HEK-293T | C49(1.14) | LDD1657 | [3] |
LDCM0455 | CL63 | HEK-293T | C49(0.96) | LDD1658 | [3] |
LDCM0456 | CL64 | HEK-293T | C49(1.11) | LDD1659 | [3] |
LDCM0457 | CL65 | HEK-293T | C49(0.96) | LDD1660 | [3] |
LDCM0458 | CL66 | HEK-293T | C49(1.00) | LDD1661 | [3] |
LDCM0459 | CL67 | HEK-293T | C49(1.23) | LDD1662 | [3] |
LDCM0460 | CL68 | HEK-293T | C49(0.60) | LDD1663 | [3] |
LDCM0461 | CL69 | HEK-293T | C49(1.11) | LDD1664 | [3] |
LDCM0462 | CL7 | HEK-293T | C49(1.27) | LDD1665 | [3] |
LDCM0463 | CL70 | HEK-293T | C49(1.03) | LDD1666 | [3] |
LDCM0464 | CL71 | HEK-293T | C49(0.75) | LDD1667 | [3] |
LDCM0465 | CL72 | HEK-293T | C49(1.12) | LDD1668 | [3] |
LDCM0466 | CL73 | HEK-293T | C49(1.00) | LDD1669 | [3] |
LDCM0467 | CL74 | HEK-293T | C49(1.08) | LDD1670 | [3] |
LDCM0469 | CL76 | HEK-293T | C49(0.99) | LDD1672 | [3] |
LDCM0470 | CL77 | HEK-293T | C49(0.89) | LDD1673 | [3] |
LDCM0471 | CL78 | HEK-293T | C49(0.95) | LDD1674 | [3] |
LDCM0472 | CL79 | HEK-293T | C49(1.13) | LDD1675 | [3] |
LDCM0473 | CL8 | HEK-293T | C49(0.72) | LDD1676 | [3] |
LDCM0474 | CL80 | HEK-293T | C49(0.70) | LDD1677 | [3] |
LDCM0475 | CL81 | HEK-293T | C49(1.07) | LDD1678 | [3] |
LDCM0476 | CL82 | HEK-293T | C49(1.17) | LDD1679 | [3] |
LDCM0477 | CL83 | HEK-293T | C49(0.81) | LDD1680 | [3] |
LDCM0478 | CL84 | HEK-293T | C49(1.09) | LDD1681 | [3] |
LDCM0479 | CL85 | HEK-293T | C49(0.92) | LDD1682 | [3] |
LDCM0480 | CL86 | HEK-293T | C49(1.04) | LDD1683 | [3] |
LDCM0481 | CL87 | HEK-293T | C49(1.02) | LDD1684 | [3] |
LDCM0482 | CL88 | HEK-293T | C49(1.04) | LDD1685 | [3] |
LDCM0483 | CL89 | HEK-293T | C49(1.09) | LDD1686 | [3] |
LDCM0484 | CL9 | HEK-293T | C49(1.11) | LDD1687 | [3] |
LDCM0485 | CL90 | HEK-293T | C49(1.02) | LDD1688 | [3] |
LDCM0486 | CL91 | HEK-293T | C49(1.13) | LDD1689 | [3] |
LDCM0487 | CL92 | HEK-293T | C49(0.88) | LDD1690 | [3] |
LDCM0488 | CL93 | HEK-293T | C49(0.99) | LDD1691 | [3] |
LDCM0489 | CL94 | HEK-293T | C49(0.95) | LDD1692 | [3] |
LDCM0490 | CL95 | HEK-293T | C49(1.02) | LDD1693 | [3] |
LDCM0491 | CL96 | HEK-293T | C49(0.99) | LDD1694 | [3] |
LDCM0492 | CL97 | HEK-293T | C49(1.00) | LDD1695 | [3] |
LDCM0493 | CL98 | HEK-293T | C49(0.97) | LDD1696 | [3] |
LDCM0494 | CL99 | HEK-293T | C49(1.08) | LDD1697 | [3] |
LDCM0027 | Dopamine | HEK-293T | 17.68 | LDD0179 | [2] |
LDCM0495 | E2913 | HEK-293T | C49(0.92) | LDD1698 | [3] |
LDCM0468 | Fragment33 | HEK-293T | C49(0.93) | LDD1671 | [3] |
LDCM0427 | Fragment51 | HEK-293T | C49(1.21) | LDD1631 | [3] |
References