Details of the Target

General Information of Target

Target ID LDTP13710
Target Name Trinucleotide repeat-containing gene 6B protein (TNRC6B)
Gene Name TNRC6B
Gene ID 23112
Synonyms
KIAA1093; Trinucleotide repeat-containing gene 6B protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTRECPSPAPGPGAPLSGSVLAEAAVVFAVVLSIHATVWDRYSWCAVALAVQAFYVQYKW
DRLLQQGSAVFQFRMSANSGLLPASMVMPLLGLVMKERCQTAGNPFFERFGIVVAATGMA
VALFSSVLALGITRPVPTNTCVILGLAGGVIIYIMKHSLSVGEVIEVLEVLLIFVYLNMI
LLYLLPRCFTPGEALLVLGGISFVLNQLIKRSLTLVESQGDPVDFFLLVVVVGMVLMGIF
FSTLFVFMDSGTWASSIFFHLMTCVLSLGVVLPWLHRLIRRNPLLWLLQFLFQTDTRIYL
LAYWSLLATLACLVVLYQNAKRSSSESKKHQAPTIARKYFHLIVVATYIPGIIFDRPLLY
VAATVCLAVFIFLEYVRYFRIKPLGHTLRSFLSLFLDERDSGPLILTHIYLLLGMSLPIW
LIPRPCTQKGSLGGARALVPYAGVLAVGVGDTVASIFGSTMGEIRWPGTKKTFEGTMTSI
FAQIISVALILIFDSGVDLNYSYAWILGSISTVSLLEAYTTQIDNLLLPLYLLILLMA
Target Bioclass
Other
Family
GW182 family
Subcellular location
Cytoplasm, P-body
Function
Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes.
Uniprot ID
Q9UPQ9
Ensemble ID
ENST00000301923.13
HGNC ID
HGNC:29190

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
Johansson_61
 Probe Info  		_(10.29)  LDD1487  [2]
DA-P3
 Probe Info  		5.53  LDD0180  [3]
AHL-Pu-1
 Probe Info  		C202(3.49)  LDD0169  [4]
HHS-475
 Probe Info  		Y593(0.44)  LDD0268  [5]
DBIA
 Probe Info  		C557(1.03); C245(1.03); C254(1.03)  LDD0078  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [8]
Lodoacetamide azide
 Probe Info  		C557(0.00); C800(0.00)  LDD0037  [7]
NAIA_4
 Probe Info  		C557(0.00); C1048(0.00)  LDD2226  [9]
NAIA_5
 Probe Info  		C800(0.00); C600(0.00)  LDD2224  [9]
Compound 10
 Probe Info  		C557(0.00); C600(0.00)  LDD2216  [10]
Compound 11
 Probe Info  		C557(0.00); C600(0.00)  LDD2213  [10]
IPM
 Probe Info  		N.A.  LDD0147  [11]
TFBX
 Probe Info  		N.A.  LDD0148  [11]
Phosphinate-6
 Probe Info  		C97(0.00); C557(0.00); C600(0.00); C800(0.00)  LDD0018  [12]
Methacrolein
 Probe Info  		N.A.  LDD0218  [13]
AOyne
 Probe Info  		12.30  LDD0443  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C202(3.49)  LDD0169  [4]
 LDCM0214  AC1 HCT 116 C245(1.23); C254(1.15); C557(1.11); C600(1.06)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C245(0.79); C254(0.92); C557(1.12)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C245(0.90); C254(0.92); C557(1.12); C600(1.01)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C245(0.94); C254(0.97); C557(1.08); C600(1.12)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C245(0.96); C254(1.01); C557(1.15); C600(1.17)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C245(1.24); C254(1.29); C557(1.51); C600(1.15)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C245(1.12); C254(1.13); C557(1.19); C600(1.05)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C245(1.13); C254(1.17); C557(1.27); C600(1.33)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C245(1.21); C254(1.20); C557(1.45); C600(1.43)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C245(1.04); C254(1.13); C557(1.31); C600(1.14)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C245(0.85); C254(0.89); C557(1.05); C600(1.17)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C245(0.82); C254(0.89); C557(1.58); C600(0.99)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C245(0.97); C254(1.05); C557(1.41)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C245(1.05); C254(1.00); C557(1.56); C600(1.21)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C245(1.02); C254(1.00); C557(1.48); C600(1.22)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C245(1.06); C254(1.02); C557(1.26); C600(1.12)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C245(0.97); C254(0.97); C557(0.95)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C245(1.21); C254(1.21); C557(0.63)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C245(1.33); C254(1.33); C557(0.85)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C245(1.47); C254(1.47); C557(0.99)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C245(1.17); C254(1.17); C557(0.84)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C245(1.11); C254(1.11); C557(0.93)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C245(1.12); C254(1.12); C557(0.83)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C245(0.72); C254(0.79); C557(0.96)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C245(1.15); C254(1.15); C557(1.16)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C245(1.31); C254(1.31); C557(1.17)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C245(1.13); C254(1.13); C557(1.11)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C245(0.96); C254(0.96); C557(0.81)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C245(1.20); C254(1.20); C557(1.04)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C245(1.01); C254(1.01); C557(0.84)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C245(1.31); C254(1.31); C557(0.94)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C245(1.33); C254(1.33); C557(0.77)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C245(1.17); C254(1.13); C557(0.95); C800(0.59)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C245(0.83); C254(0.83); C557(0.73); C800(0.65)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C245(1.07); C254(1.00); C557(0.93); C800(0.73)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C245(0.96); C254(0.91); C557(0.77); C800(0.63)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C245(0.67); C254(0.67); C557(0.62); C800(0.76)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C245(0.76); C254(0.77); C557(0.69); C800(0.57)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C245(0.84); C254(0.87); C557(0.79); C800(0.78)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C245(0.75); C254(0.79); C557(0.73); C800(0.67)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C245(0.78); C254(0.81); C557(0.81); C800(0.72)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C245(0.84); C254(0.80); C557(0.66); C800(0.66)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C245(0.77); C254(0.78); C557(0.69); C800(0.81)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C245(0.80); C254(0.80); C557(0.73); C800(0.90)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C245(0.75); C254(0.79); C557(1.00)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C245(0.78); C254(0.83); C557(0.73); C800(0.70)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C245(0.83); C254(0.87); C557(0.85); C800(1.20)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C245(0.61); C254(0.64); C557(0.60); C800(0.76)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C557(1.05); C245(1.07); C254(1.07)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C557(1.38); C254(1.46); C245(1.48)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C557(1.06); C254(1.16); C245(1.21)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C557(1.21); C245(1.23); C254(1.24)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C245(1.32); C254(1.32); C557(1.48)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C557(1.67); C254(1.83); C245(1.85)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C557(1.45); C254(1.50); C245(1.57)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C245(0.80); C254(0.86); C557(1.21)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C557(1.04); C254(1.04); C245(1.09)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C557(1.12); C245(1.18); C254(1.23)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C245(1.44); C254(1.45); C557(1.54)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C254(2.38); C245(2.43); C557(2.61)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C245(1.37); C254(1.40); C557(1.54)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C245(1.88); C254(1.86); C557(1.46)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C245(1.20); C254(1.19); C557(1.21)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C245(1.47); C254(1.49); C557(1.20)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C557(0.88); C600(0.90); C254(1.03); C245(1.10)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C600(0.77); C557(0.78); C254(1.13); C245(1.24)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C600(0.69); C557(1.08); C254(1.21); C245(1.46)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C557(0.96); C800(1.04); C245(1.06); C254(1.07)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C600(0.83); C557(0.93); C254(1.19); C245(1.30)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C600(0.72); C557(1.28); C254(1.43); C245(1.65)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C600(0.75); C557(0.99); C254(1.03); C245(1.08)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C600(0.71); C557(0.93); C254(1.26); C245(1.43)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C600(0.75); C557(0.81); C254(1.04); C245(1.19)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C557(1.00); C245(1.04); C254(1.15)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C245(1.08); C557(1.09); C254(1.09)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C245(1.01); C254(1.10); C557(1.26)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C557(1.12); C245(1.21); C254(1.34)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C557(1.28); C245(2.03); C254(2.10)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C254(0.96); C245(1.00); C557(1.00); C800(1.05)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C557(1.09); C245(1.23); C254(1.33)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C245(0.97); C254(1.05); C557(1.12)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C245(1.19); C254(1.33); C557(1.44)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C557(1.29); C245(1.56); C254(1.59)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C245(1.46); C254(1.57); C557(1.62)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C557(0.98); C245(1.24); C254(1.24)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C557(0.83); C245(1.27); C254(1.27)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C557(0.85); C245(1.17); C254(1.17)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C245(1.00); C254(1.00); C557(1.00)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C245(1.15); C254(1.15); C557(1.18)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C800(0.90); C254(1.01); C557(1.01); C245(1.02)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C557(1.04); C245(1.42); C254(1.42)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C557(0.94); C245(1.76); C254(1.76)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C557(1.03); C245(1.34); C254(1.34)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C557(0.97); C245(1.83); C254(1.83)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C557(0.90); C245(1.68); C254(1.68)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C557(1.07); C245(1.89); C254(1.89)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C557(1.04); C254(1.19); C245(1.22)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C557(1.07); C254(1.13); C245(1.17)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C245(0.82); C254(0.85); C557(0.96)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C254(1.48); C245(1.52); C557(1.56)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C254(0.82); C245(0.84); C800(0.85); C557(0.97)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C254(1.39); C245(1.41); C557(1.50)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C254(0.84); C245(0.87); C557(0.92)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C245(0.95); C254(0.96); C557(1.05)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C245(1.34); C254(1.41); C557(1.57)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C254(1.24); C245(1.24); C557(1.41)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C557(1.73); C254(1.74); C245(1.86)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C557(2.94); C254(3.05); C245(3.64)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C245(1.07); C254(1.17); C557(1.37)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C245(1.17); C254(1.21); C557(1.69)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C245(1.12); C254(1.14); C557(1.44)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C245(0.84); C254(0.92); C557(1.16)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C245(0.93); C254(1.02); C557(1.81)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C245(0.72); C254(0.84); C557(1.30)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C245(0.98); C254(1.08); C557(1.33)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C245(0.97); C254(0.99); C557(1.17)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C245(0.93); C254(0.97); C557(1.28)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C245(0.51); C254(0.64); C557(0.68)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C245(0.50); C254(0.58); C557(0.72)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C245(0.75); C557(0.75); C254(0.77)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C245(0.84); C254(0.84); C800(1.09); C557(1.59)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C245(0.84); C254(0.84); C800(1.56); C557(1.78)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C245(0.67); C254(0.78); C557(0.92)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C245(0.91); C254(0.91); C800(1.09); C557(1.59)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C245(0.71); C254(0.71); C800(1.01); C557(1.41)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C245(1.03); C254(1.03); C800(1.47); C557(2.21)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C245(1.47); C254(1.47); C800(2.00); C557(2.45)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C245(1.27); C254(1.27); C800(1.60); C557(1.70)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C800(1.86); C245(2.04); C254(2.04); C557(3.10)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C245(0.98); C254(0.98); C800(1.19); C557(1.44)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C800(1.14); C245(1.20); C254(1.20); C557(1.86)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C800(0.91); C245(0.93); C254(0.93); C557(1.56)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C245(0.81); C254(0.81); C800(0.91); C557(2.13)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C245(0.71); C254(0.77); C557(1.07)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C245(1.19); C254(1.19); C800(1.46); C557(1.58)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C245(0.80); C254(0.80); C800(0.89); C557(1.56)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C245(1.88); C254(1.88); C800(2.12); C557(2.26)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C254(1.96); C245(2.12); C557(2.25)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C254(1.72); C245(1.84); C557(1.87)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C557(1.49); C254(1.53); C245(1.59)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C254(1.51); C557(1.53); C245(1.62)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C557(1.24); C254(1.30); C245(1.43)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C557(1.62); C254(1.70); C245(1.88)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C557(1.79); C254(1.87); C245(2.06)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C557(1.19); C254(1.30); C245(1.38)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C254(2.43); C557(2.64); C245(2.65)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C557(2.26); C254(2.42); C245(2.71)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C557(1.55); C254(1.85); C245(2.12)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C557(1.69); C254(1.81); C245(1.90)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C254(1.50); C557(1.51); C245(1.68)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C557(1.98); C254(2.13); C245(2.44)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C254(2.25); C557(2.27); C245(2.50)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C600(1.34); C800(1.52); C245(1.81); C254(1.88)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C245(0.83); C254(0.89); C557(1.06); C800(1.30)  LDD0683  [6]
 LDCM0248  AKOS034007472 HCT 116 C245(0.78); C254(0.87); C557(1.01)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C245(0.80); C254(0.92); C557(1.05)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C245(1.14); C254(1.27); C557(1.87)  LDD0592  [6]
 LDCM0156  Aniline NCI-H1299 11.67  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C557(1.03); C245(1.03); C254(1.03)  LDD0078  [6]
 LDCM0087  Capsaicin HEK-293T 13.55  LDD0185  [3]
 LDCM0632  CL-Sc Hep-G2 C600(1.15)  LDD2227  [9]
 LDCM0367  CL1 HCT 116 C245(0.82); C254(0.82); C557(1.07)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C245(1.38); C254(1.38); C557(1.58)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C800(1.00); C600(1.06); C557(1.09); C254(1.42)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C245(0.80); C254(0.99); C557(1.20)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C245(0.66); C254(0.76); C557(0.99)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C254(0.78); C245(0.79); C557(0.98)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C254(0.83); C245(0.86); C557(1.01)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C600(0.73); C557(1.12); C254(1.22); C245(1.26)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C600(0.64); C254(1.46); C557(1.48); C245(1.60)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C600(0.80); C245(1.13); C254(1.16); C557(1.17)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C600(0.65); C245(1.24); C254(1.29); C557(1.32)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C600(0.86); C557(1.15); C254(1.33); C245(1.52)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C245(1.40); C254(1.40); C557(1.76)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C600(0.80); C557(1.27); C254(1.61); C245(1.81)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C600(0.78); C557(1.17); C254(1.34); C245(1.43)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C557(1.06); C245(1.14); C254(1.20)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C245(1.29); C254(1.41); C557(1.50)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C245(1.14); C254(1.23); C557(1.44)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C557(1.55); C254(1.68); C245(1.69)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C557(1.05); C245(1.09); C254(1.22)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C245(1.52); C254(1.52); C557(1.72)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C557(0.92); C245(1.20); C254(1.20)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C557(1.07); C245(1.52); C254(1.52)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C557(1.67); C245(1.78); C254(1.78)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C557(0.92); C245(1.43); C254(1.43)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C557(1.17); C254(2.29); C245(2.66)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C245(0.88); C254(0.88); C557(1.14)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C254(1.56); C245(1.65); C557(1.75)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C254(1.46); C245(1.50); C557(1.60)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C245(0.82); C254(0.89); C557(0.91)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C245(0.75); C254(0.88); C557(1.33)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C245(0.67); C254(0.72); C557(0.97)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C245(1.26); C254(1.36); C557(1.48)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C245(0.96); C254(0.96); C557(1.50)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C245(1.10); C254(1.10); C557(1.30)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C245(1.05); C254(1.05); C557(1.53)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C600(0.99); C245(1.04); C254(1.04); C557(1.13)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C600(0.77); C245(0.81); C254(0.81); C557(1.17)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C245(0.93); C254(0.93); C600(1.05); C557(1.19)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C600(0.85); C245(1.06); C254(1.06); C557(1.15)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C245(0.94); C254(0.94); C557(1.09)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C600(0.95); C245(1.30); C254(1.30); C557(1.41)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C600(0.95); C245(1.34); C254(1.34); C557(1.49)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C600(0.99); C245(1.53); C254(1.53); C557(1.74)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C245(0.98); C254(0.98); C557(1.03); C600(1.12)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C245(1.14); C254(1.14); C557(1.33); C600(0.85)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C245(0.99); C254(0.99); C557(1.43); C600(0.87)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C245(0.94); C254(0.94); C557(1.31); C600(1.02)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C245(0.92); C254(0.92); C557(1.21); C600(0.90)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C245(0.98); C254(0.98); C557(1.32); C600(1.00)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C245(1.19); C254(1.19); C557(1.30); C600(0.99)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C245(1.01); C254(1.01); C557(1.18)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C245(0.79); C254(0.79); C557(0.97); C600(0.81)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C245(0.90); C254(0.90); C557(1.18)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C245(0.96); C254(0.96); C557(1.18)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C245(0.77); C254(0.77); C557(1.40)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C245(1.17); C254(1.17); C557(1.52)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C245(1.65); C254(1.65); C557(1.53)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C245(0.98); C254(0.98); C557(1.43)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C245(1.64); C254(1.64); C557(1.59)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C245(1.07); C254(1.07); C557(1.54)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C245(1.19); C254(1.19); C557(1.44)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C245(1.31); C254(1.31); C557(1.41)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C245(1.14); C254(1.14); C557(1.43)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C245(1.64); C254(1.64); C557(2.45)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C245(1.29); C254(1.29); C557(1.49)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C245(1.13); C254(1.13); C557(1.37)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C245(1.31); C254(1.31); C557(1.70)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C245(0.89); C254(0.89); C557(0.83); C800(0.97)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C245(0.89); C254(0.89); C557(0.81); C800(0.83)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C245(1.04); C254(1.04); C557(0.70); C800(0.82)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C245(1.21); C254(1.21); C557(0.88); C800(0.85)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C245(1.14); C254(1.14); C557(1.08)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C245(1.10); C254(1.10); C557(0.85); C800(0.80)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C245(1.21); C254(1.21); C557(0.93); C800(0.86)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C245(1.28); C254(1.28); C557(0.90); C800(0.83)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C245(1.24); C254(1.24); C557(0.79); C800(0.83)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C245(1.29); C254(1.29); C557(0.83); C800(0.74)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C245(1.20); C254(1.20); C557(0.77); C800(0.79)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C245(1.04); C254(1.04); C557(0.94); C800(0.70)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C245(0.84); C254(0.84); C557(0.82); C800(0.71)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C245(1.05); C254(1.05); C557(0.78); C800(0.81)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C245(1.16); C254(1.16); C557(0.90); C800(0.82)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C245(1.23); C254(1.23); C557(1.47)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C245(1.04); C254(1.04); C557(0.90); C800(0.74)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C245(1.06); C254(1.06); C557(1.09)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C245(1.04); C254(1.04); C557(1.15)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C245(1.23); C254(1.23); C557(1.25)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C245(1.29); C254(1.29); C557(1.40)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C245(0.88); C254(0.88); C557(1.07)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C245(0.89); C254(0.89); C557(1.64)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C245(1.20); C254(1.20); C557(1.52)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C245(0.96); C254(0.96); C557(1.41)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C245(0.96); C254(0.96); C557(1.26)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C245(1.24); C254(1.24); C557(1.35)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C245(1.18); C254(1.18); C557(1.39)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C245(1.51); C254(1.51); C557(1.90)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C245(1.28); C254(1.28); C557(1.21)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C245(1.11); C254(1.11); C557(1.43)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C245(1.33); C254(1.33); C557(1.53)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C245(1.01); C254(1.01); C557(1.17)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C245(0.74); C254(0.74); C557(1.06)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C245(1.05); C254(1.05); C557(1.15)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C245(1.36); C254(1.36); C557(1.49)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C245(1.40); C254(1.40); C557(1.99)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C245(0.80); C254(0.80); C557(0.92)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C245(1.02); C254(1.02); C557(1.29)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C245(1.11); C254(1.11); C557(1.70)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C245(0.96); C254(0.96); C557(1.35)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C245(1.13); C254(1.13); C557(1.69)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C245(0.81); C254(0.81); C557(0.93)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C245(0.61); C254(0.61); C557(0.90)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C245(0.61); C254(0.61); C557(0.99)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C245(1.12); C254(1.12); C557(1.31)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C245(1.30); C254(1.30); C557(1.92)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C245(1.13); C254(1.13); C557(1.25)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C245(0.61); C254(0.61); C557(0.99)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C245(1.07); C254(1.03); C557(1.41); C600(1.14)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C245(0.96); C254(0.99); C557(1.14); C600(1.04)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C245(0.80); C254(0.85); C557(1.10); C600(0.94)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C245(1.39); C254(1.32); C557(1.53); C600(1.05)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C245(1.28); C254(1.26); C557(1.58); C600(1.07)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C245(1.53); C254(1.30); C557(1.36); C600(1.03)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C245(1.16); C254(1.08); C557(1.08); C600(0.97)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C245(1.53); C254(1.39); C557(1.09); C600(1.09)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C245(1.24); C254(1.27); C557(1.06); C600(0.98)  LDD0811  [6]
 LDCM0634  CY-0357 Hep-G2 C202(0.66)  LDD2228  [9]
 LDCM0028  Dobutamine HEK-293T 5.53  LDD0180  [3]
 LDCM0495  E2913 HEK-293T C557(1.05); C800(1.03); C600(1.16); C202(1.04)  LDD1698  [15]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C557(5.02)  LDD1702  [16]
 LDCM0468  Fragment33 HCT 116 C245(1.16); C254(1.16); C557(1.56)  LDD0785  [6]
 LDCM0427  Fragment51 HCT 116 C245(1.59); C254(1.59); C557(2.17)  LDD0744  [6]
 LDCM0615  Fragment63-R Jurkat _(10.29)  LDD1487  [2]
 LDCM0120  HHS-0701 DM93 Y593(0.44)  LDD0268  [5]
 LDCM0022  KB02 HCT 116 C245(4.64); C254(1.43); C800(1.74); C557(2.19)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C245(1.94); C254(0.83); C800(1.13); C557(1.15)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C245(2.61); C254(1.77); C800(1.40); C557(1.28)  LDD0082  [6]
 LDCM0032  Oleacein HEK-293T 12.55  LDD0184  [3]
 LDCM0021  THZ1 HCT 116 C245(0.97); C254(0.97); C557(0.98)  LDD2173  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein argonaute-2 (AGO2) Argonaute family Q9UKV8
PAN2-PAN3 deadenylation complex subunit PAN3 (PAN3) PAN3 family Q58A45
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein argonaute-1 (AGO1) Argonaute family Q9UL18
CCR4-NOT transcription complex subunit 1 (CNOT1) CNOT1 family A5YKK6
Polyadenylate-binding protein 1 (PABPC1) Polyadenylate-binding protein type-1 family P11940

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
3 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
13 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761