Details of the Target

General Information of Target

Target ID LDTP04199
Target Name Protein PRRC2A (PRRC2A)
Gene Name PRRC2A
Gene ID 7916
Synonyms
BAT2; G2; Protein PRRC2A; HLA-B-associated transcript 2; Large proline-rich protein BAT2; Proline-rich and coiled-coil-containing protein 2A; Protein G2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSDRSGPTAKGKDGKKYSSLNLFDTYKGKSLEIQKPAVAPRHGLQSLGKVAIARRMPPPA
NLPSLKAENKGNDPNVSLVPKDGTGWASKQEQSDPKSSDASTAQPPESQPLPASQTPASN
QPKRPPAAPENTPLVPSGVKSWAQASVTHGAHGDGGRASSLLSRFSREEFPTLQAAGDQD
KAAKERESAEQSSGPGPSLRPQNSTTWRDGGGRGPDELEGPDSKLHHGHDPRGGLQPSGP
PQFPPYRGMMPPFMYPPYLPFPPPYGPQGPYRYPTPDGPSRFPRVAGPRGSGPPMRLVEP
VGRPSILKEDNLKEFDQLDQENDDGWAGAHEEVDYTEKLKFSDEEDGRDSDEEGAEGHRD
SQSASGEERPPEADGKKGNSPNSEPPTPKTAWAETSRPPETEPGPPAPKPPLPPPHRGPA
GNWGPPGDYPDRGGPPCKPPAPEDEDEAWRQRRKQSSSEISLAVERARRRREEEERRMQE
ERRAACAEKLKRLDEKFGAPDKRLKAEPAAPPAAPSTPAPPPAVPKELPAPPAPPPASAP
TPETEPEEPAQAPPAQSTPTPGVAAAPTLVSGGGSTSSTSSGSFEASPVEPQLPSKEGPE
PPEEVPPPTTPPVPKVEPKGDGIGPTRQPPSQGLGYPKYQKSLPPRFQRQQQEQLLKQQQ
QHQWQQHQQGSAPPTPVPPSPPQPVTLGAVPAPQAPPPPPKALYPGALGRPPPMPPMNFD
PRWMMIPPYVDPRLLQGRPPLDFYPPGVHPSGLVPRERSDSGGSSSEPFDRHAPAMLRER
GTPPVDPKLAWVGDVFTATPAEPRPLTSPLRQAADEDDKGMRSETPPVPPPPPYLASYPG
FPENGAPGPPISRFPLEEPGPRPLPWPPGSDEVAKIQTPPPKKEPPKEETAQLTGPEAGR
KPARGVGSGGQGPPPPRRESRTETRWGPRPGSSRRGIPPEEPGAPPRRAGPIKKPPPPTK
VEELPPKPLEQGDETPKPPKPDPLKITKGKLGGPKETPPNGNLSPAPRLRRDYSYERVGP
TSCRGRGRGEYFARGRGFRGTYGGRGRGARSREFRSYREFRGDDGRGGGTGGPNHPPAPR
GRTASETRSEGSEYEEIPKRRRQRGSETGSETHESDLAPSDKEAPTPKEGTLTQVPLAPP
PPGAPPSPAPARFTARGGRVFTPRGVPSRRGRGGGRPPPQVCPGWSPPAKSLAPKKPPTG
PLPPSKEPLKEKLIPGPLSPVARGGSNGGSNVGMEDGERPRRRRHGRAQQQDKPPRFRRL
KQERENAARGSEGKPSLTLPASAPGPEEALTTVTVAPAPRRAAAKSPDLSNQNSDQANEE
WETASESSDFTSERRGDKEAPPPVLLTPKAVGTPGGGGGGAVPGISAMSRGDLSQRAKDL
SKRSFSSQRPGMERQNRRPGPGGKAGSSGSSSGGGGGGPGGRTGPGRGDKRSWPSPKNRS
RPPEERPPGLPLPPPPPSSSAVFRLDQVIHSNPAGIQQALAQLSSRQGSVTAPGGHPRHK
PGLPQAPQGPSPRPPTRYEPQRVNSGLSSDPHFEEPGPMVRGVGGTPRDSAGVSPFPPKR
RERPPRKPELLQEESLPPPHSSGFLGSKPEGPGPQAESRDTGTEALTPHIWNRLHTATSR
KSYRPSSMEPWMEPLSPFEDVAGTEMSQSDSGVDLSGDSQVSSGPCSQRSSPDGGLKGAA
EGPPKRPGGSSPLNAVPCEGPPGSEPPRRPPPAPHDGDRKELPREQPLPPGPIGTERSQR
TDRGTEPGPIRPSHRPGPPVQFGTSDKDSDLRLVVGDSLKAEKELTASVTEAIPVSRDWE
LLPSAAASAEPQSKNLDSGHCVPEPSSSGQRLYPEVFYGSAGPSSSQISGGAMDSQLHPN
SGGFRPGTPSLHPYRSQPLYLPPGPAPPSALLSGLALKGQFLDFSTMQATELGKLPAGGV
LYPPPSFLYSPAFCPSPLPDTSLLQVRQDLPSPSDFYSTPLQPGGQSGFLPSGAPAQQML
LPMVDSQLPVVNFGSLPPAPPPAPPPLSLLPVGPALQPPSLAVRPPPAPATRVLPSPARP
FPASLGRAELHPVELKPFQDYQKLSSNLGGPGSSRTPPTGRSFSGLNSRLKATPSTYSGV
FRTQRVDLYQQASPPDALRWIPKPWERTGPPPREGPSRRAEEPGSRGDKEPGLPPPR
Target Bioclass
Other
Subcellular location
Cytoplasm
Function May play a role in the regulation of pre-mRNA splicing.
Uniprot ID
P48634
Ensemble ID
ENST00000376007.8
HGNC ID
HGNC:13918

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
C32 SNV: p.M254V .
CAMA1 SNV: p.E547K; p.R1061Ter DBIA    Probe Info 
COLO678 SNV: p.S1484I DBIA    Probe Info 
DU4475 Insertion: p.Q1812HfsTer85 .
HCT15 SNV: p.P746H .
HT Insertion: p.S631Ter .
JURKAT Deletion: p.H1113MfsTer97;p.L1450FfsTer41
SNV: p.R281P;p.G622V;p.S1765N;p.A1917V		 Compound 10    Probe Info 
KYSE30 SNV: p.Q651H DBIA    Probe Info 
LNCaP clone FGC SNV: p.S64I; p.G2085D DBIA    Probe Info 
LS180 SNV: p.R756Ter DBIA    Probe Info 
MCC13 SNV: p.P554L DBIA    Probe Info 
MDAMB453 SNV: p.G1048E DBIA    Probe Info 
MFE319 SNV: p.A1084V DBIA    Probe Info 
MOLT4 SNV: p.G71D; p.R213C; p.A1267V; p.D1308Y; p.P2124S IA-alkyne    Probe Info 
PC14 SNV: p.R853H .
PC9 SNV: p.R853H .
RL SNV: p.V690G .
SNU1 SNV: p.R477C; p.V1468A DBIA    Probe Info 
SW1116 SNV: p.S1845R .
TCCSUP SNV: p.R2032W DBIA    Probe Info 
TOV21G SNV: p.H416N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.97  LDD0402  [1]
A-EBA
 Probe Info  		2.48  LDD0215  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
TH211
 Probe Info  		Y1922(8.81)  LDD0257  [4]
STPyne
 Probe Info  		K27(0.14); K496(8.50); K502(6.67)  LDD0277  [5]
DBIA
 Probe Info  		C437(2.72)  LDD3321  [6]
DA-P3
 Probe Info  		4.90  LDD0181  [7]
AHL-Pu-1
 Probe Info  		C437(7.92)  LDD0169  [8]
ATP probe
 Probe Info  		K489(0.00); K491(0.00)  LDD0199  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [10]
IA-alkyne
 Probe Info  		C486(0.00); C437(0.00)  LDD0162  [11]
Lodoacetamide azide
 Probe Info  		C437(0.00); C486(0.00)  LDD0037  [10]
NAIA_4
 Probe Info  		N.A.  LDD2226  [12]
TFBX
 Probe Info  		N.A.  LDD0027  [13]
Compound 10
 Probe Info  		N.A.  LDD2216  [14]
Compound 11
 Probe Info  		N.A.  LDD2213  [14]
IPM
 Probe Info  		N.A.  LDD0005  [15]
VSF
 Probe Info  		N.A.  LDD0007  [15]
Phosphinate-6
 Probe Info  		C1821(0.00); C437(0.00); C486(0.00)  LDD0018  [16]
1d-yne
 Probe Info  		N.A.  LDD0357  [17]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		20.00  LDD0475  [18]
FFF probe14
 Probe Info  		12.74  LDD0477  [18]
FFF probe2
 Probe Info  		20.00  LDD0463  [18]
FFF probe3
 Probe Info  		20.00  LDD0464  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C437(4.39)  LDD0170  [8]
 LDCM0026  4SU-RNA+native RNA HEK-293T C437(7.92)  LDD0169  [8]
 LDCM0214  AC1 HEK-293T C1821(1.06)  LDD0812  [19]
 LDCM0215  AC10 HEK-293T C437(0.98); C1934(0.82)  LDD1508  [20]
 LDCM0226  AC11 HEK-293T C437(0.96); C1934(0.91)  LDD1509  [20]
 LDCM0230  AC113 HEK-293T C1821(1.07)  LDD0828  [19]
 LDCM0231  AC114 HEK-293T C1821(0.96)  LDD0829  [19]
 LDCM0232  AC115 HEK-293T C1821(0.97)  LDD0830  [19]
 LDCM0233  AC116 HEK-293T C1821(0.90)  LDD0831  [19]
 LDCM0234  AC117 HEK-293T C1821(0.92)  LDD0832  [19]
 LDCM0235  AC118 HEK-293T C1821(1.03)  LDD0833  [19]
 LDCM0236  AC119 HEK-293T C1821(0.91)  LDD0834  [19]
 LDCM0237  AC12 HEK-293T C437(0.91); C1934(1.00); C1698(1.52)  LDD1510  [20]
 LDCM0238  AC120 HEK-293T C1821(1.25)  LDD0836  [19]
 LDCM0239  AC121 HEK-293T C1821(1.01)  LDD0837  [19]
 LDCM0240  AC122 HEK-293T C1821(1.21)  LDD0838  [19]
 LDCM0241  AC123 HEK-293T C1821(1.08)  LDD0839  [19]
 LDCM0242  AC124 HEK-293T C1821(0.96)  LDD0840  [19]
 LDCM0243  AC125 HEK-293T C1821(1.11)  LDD0841  [19]
 LDCM0244  AC126 HEK-293T C1821(1.50)  LDD0842  [19]
 LDCM0245  AC127 HEK-293T C1821(1.32)  LDD0843  [19]
 LDCM0259  AC14 HEK-293T C1821(1.10); C437(1.02); C1934(1.08); C1698(1.06)  LDD1512  [20]
 LDCM0270  AC15 HEK-293T C437(1.04); C1934(1.12); C1698(1.06)  LDD1513  [20]
 LDCM0276  AC17 HEK-293T C1821(1.05); C1934(0.83)  LDD0874  [19]
 LDCM0277  AC18 HEK-293T C1821(1.07); C1934(0.91)  LDD0875  [19]
 LDCM0278  AC19 HEK-293T C1821(0.98); C1934(0.85)  LDD0876  [19]
 LDCM0279  AC2 HEK-293T C1821(0.96)  LDD0877  [19]
 LDCM0280  AC20 HEK-293T C1821(1.04); C1934(0.88)  LDD0878  [19]
 LDCM0281  AC21 HEK-293T C1821(0.96); C1934(0.81)  LDD0879  [19]
 LDCM0282  AC22 HEK-293T C1821(0.99); C1934(0.86)  LDD0880  [19]
 LDCM0283  AC23 HEK-293T C1821(1.02); C1934(0.94)  LDD0881  [19]
 LDCM0284  AC24 HEK-293T C1821(1.14); C1934(0.78)  LDD0882  [19]
 LDCM0285  AC25 HEK-293T C1934(0.97)  LDD0883  [19]
 LDCM0286  AC26 HEK-293T C1934(1.06)  LDD0884  [19]
 LDCM0287  AC27 HEK-293T C1934(1.14)  LDD0885  [19]
 LDCM0288  AC28 HEK-293T C1934(0.81)  LDD0886  [19]
 LDCM0289  AC29 HEK-293T C1934(1.16)  LDD0887  [19]
 LDCM0290  AC3 HEK-293T C1821(0.95)  LDD0888  [19]
 LDCM0291  AC30 HEK-293T C1934(1.05)  LDD0889  [19]
 LDCM0292  AC31 HEK-293T C1934(1.01)  LDD0890  [19]
 LDCM0293  AC32 HEK-293T C1934(1.06)  LDD0891  [19]
 LDCM0294  AC33 HEK-293T C1934(1.03)  LDD0892  [19]
 LDCM0295  AC34 HEK-293T C1934(0.97)  LDD0893  [19]
 LDCM0296  AC35 HEK-293T C437(1.01); C1934(0.92)  LDD1535  [20]
 LDCM0297  AC36 HEK-293T C437(0.80); C1934(1.14); C1698(1.63)  LDD1536  [20]
 LDCM0298  AC37 HEK-293T C1821(1.08); C437(0.94); C1934(1.31)  LDD1537  [20]
 LDCM0299  AC38 HEK-293T C1821(1.19); C437(0.96); C1934(1.09); C1698(1.09)  LDD1538  [20]
 LDCM0300  AC39 HEK-293T C437(0.99); C1934(1.09); C1698(0.84)  LDD1539  [20]
 LDCM0301  AC4 HEK-293T C1821(1.03)  LDD0899  [19]
 LDCM0302  AC40 HEK-293T C1821(1.08); C437(0.94); C1934(1.04); C1698(0.98)  LDD1541  [20]
 LDCM0303  AC41 HEK-293T C1821(1.11); C437(1.06); C1934(1.17)  LDD1542  [20]
 LDCM0304  AC42 HEK-293T C437(1.05); C1934(1.22)  LDD1543  [20]
 LDCM0305  AC43 HEK-293T C437(0.97); C1934(1.03)  LDD1544  [20]
 LDCM0306  AC44 HEK-293T C437(0.90); C1934(1.03); C1698(1.15)  LDD1545  [20]
 LDCM0307  AC45 HEK-293T C1821(1.01); C437(1.00); C1934(1.15)  LDD1546  [20]
 LDCM0308  AC46 HEK-293T C1821(0.80); C1934(0.93)  LDD0906  [19]
 LDCM0309  AC47 HEK-293T C1821(0.78); C1934(1.08)  LDD0907  [19]
 LDCM0310  AC48 HEK-293T C1821(0.86); C1934(1.10)  LDD0908  [19]
 LDCM0311  AC49 HEK-293T C1821(0.97); C1934(1.03)  LDD0909  [19]
 LDCM0312  AC5 HEK-293T C1821(1.10)  LDD0910  [19]
 LDCM0313  AC50 HEK-293T C1821(0.89); C1934(1.01)  LDD0911  [19]
 LDCM0314  AC51 HEK-293T C1821(0.81); C1934(1.22)  LDD0912  [19]
 LDCM0315  AC52 HEK-293T C1821(0.88); C1934(1.10)  LDD0913  [19]
 LDCM0316  AC53 HEK-293T C1821(0.96); C1934(1.02)  LDD0914  [19]
 LDCM0317  AC54 HEK-293T C1821(0.88); C1934(1.21)  LDD0915  [19]
 LDCM0318  AC55 HEK-293T C1821(0.90); C1934(1.10)  LDD0916  [19]
 LDCM0319  AC56 HEK-293T C1821(0.89); C1934(1.06)  LDD0917  [19]
 LDCM0320  AC57 HEK-293T C1821(1.09); C437(1.02); C1934(1.36)  LDD1559  [20]
 LDCM0321  AC58 HEK-293T C437(0.93); C1934(0.75)  LDD1560  [20]
 LDCM0322  AC59 HEK-293T C437(0.94); C1934(1.09)  LDD1561  [20]
 LDCM0323  AC6 HEK-293T C1821(0.91); C437(1.08); C1934(1.10); C1698(1.00)  LDD1562  [20]
 LDCM0324  AC60 HEK-293T C437(0.84); C1934(1.03); C1698(1.35)  LDD1563  [20]
 LDCM0325  AC61 HEK-293T C1821(1.05); C437(0.98); C1934(1.19)  LDD1564  [20]
 LDCM0326  AC62 HEK-293T C1821(1.14); C437(0.95); C1934(1.41); C1698(1.19)  LDD1565  [20]
 LDCM0327  AC63 HEK-293T C437(1.01); C1934(1.04); C1698(1.20)  LDD1566  [20]
 LDCM0328  AC64 HEK-293T C1821(0.91); C437(0.92); C1934(1.08); C1698(1.29)  LDD1567  [20]
 LDCM0332  AC68 HEK-293T C1934(0.94)  LDD0930  [19]
 LDCM0333  AC69 HEK-293T C1934(1.06)  LDD0931  [19]
 LDCM0334  AC7 HEK-293T C437(0.97); C1934(0.96); C1698(0.84)  LDD1568  [20]
 LDCM0335  AC70 HEK-293T C1934(0.95)  LDD0933  [19]
 LDCM0336  AC71 HEK-293T C1934(1.10)  LDD0934  [19]
 LDCM0337  AC72 HEK-293T C1934(0.81)  LDD0935  [19]
 LDCM0338  AC73 HEK-293T C1934(0.86)  LDD0936  [19]
 LDCM0339  AC74 HEK-293T C1934(0.81)  LDD0937  [19]
 LDCM0340  AC75 HEK-293T C1934(1.04)  LDD0938  [19]
 LDCM0341  AC76 HEK-293T C1934(0.83)  LDD0939  [19]
 LDCM0342  AC77 HEK-293T C1934(0.87)  LDD0940  [19]
 LDCM0343  AC78 HEK-293T C1934(0.91)  LDD0941  [19]
 LDCM0344  AC79 HEK-293T C1934(0.88)  LDD0942  [19]
 LDCM0345  AC8 HEK-293T C1821(1.09); C437(0.89); C1934(1.05); C1698(0.90)  LDD1569  [20]
 LDCM0346  AC80 HEK-293T C1934(0.97)  LDD0944  [19]
 LDCM0347  AC81 HEK-293T C1934(0.81)  LDD0945  [19]
 LDCM0348  AC82 HEK-293T C1934(1.14)  LDD0946  [19]
 LDCM0248  AKOS034007472 HEK-293T C1821(0.98); C437(0.94); C1934(1.27)  LDD1511  [20]
 LDCM0356  AKOS034007680 HEK-293T C1821(1.15); C437(1.08); C1934(1.13)  LDD1570  [20]
 LDCM0275  AKOS034007705 HEK-293T C1821(0.98); C437(0.88); C1934(1.11); C1698(1.04)  LDD1514  [20]
 LDCM0156  Aniline NCI-H1299 11.55  LDD0403  [1]
 LDCM0087  Capsaicin HEK-293T 37.96  LDD0185  [7]
 LDCM0630  CCW28-3 231MFP C437(1.64)  LDD2214  [21]
 LDCM0367  CL1 HEK-293T C1821(1.00); C437(0.83); C1934(1.05); C1698(1.34)  LDD1571  [20]
 LDCM0368  CL10 HEK-293T C1821(1.07); C437(0.95); C1934(0.93); C1698(0.97)  LDD1572  [20]
 LDCM0369  CL100 HEK-293T C1821(0.89)  LDD0967  [19]
 LDCM0370  CL101 HEK-293T C1821(0.96); C437(1.01); C1934(1.11); C1698(1.23)  LDD1574  [20]
 LDCM0371  CL102 HEK-293T C1821(1.02); C437(0.95); C1934(1.10); C1698(1.42)  LDD1575  [20]
 LDCM0372  CL103 HEK-293T C437(0.96); C1934(0.97); C1698(1.12)  LDD1576  [20]
 LDCM0373  CL104 HEK-293T C437(0.88); C1934(1.05)  LDD1577  [20]
 LDCM0374  CL105 HEK-293T C1821(1.05); C1934(0.84)  LDD0972  [19]
 LDCM0375  CL106 HEK-293T C1821(1.00); C1934(0.88)  LDD0973  [19]
 LDCM0376  CL107 HEK-293T C1821(1.17); C1934(0.79)  LDD0974  [19]
 LDCM0377  CL108 HEK-293T C1821(0.97); C1934(0.89)  LDD0975  [19]
 LDCM0378  CL109 HEK-293T C1821(1.07); C1934(0.77)  LDD0976  [19]
 LDCM0379  CL11 HEK-293T C437(1.03); C1934(0.90); C1698(1.56)  LDD1583  [20]
 LDCM0380  CL110 HEK-293T C1821(1.01); C1934(0.80)  LDD0978  [19]
 LDCM0381  CL111 HEK-293T C1821(1.05); C1934(0.72)  LDD0979  [19]
 LDCM0382  CL112 HEK-293T C1934(0.98)  LDD0980  [19]
 LDCM0383  CL113 HEK-293T C1934(0.99)  LDD0981  [19]
 LDCM0384  CL114 HEK-293T C1934(1.14)  LDD0982  [19]
 LDCM0385  CL115 HEK-293T C1934(1.00)  LDD0983  [19]
 LDCM0386  CL116 HEK-293T C1934(1.15)  LDD0984  [19]
 LDCM0387  CL117 HEK-293T C1821(0.94); C437(0.86); C1934(1.08); C1698(1.07)  LDD1591  [20]
 LDCM0388  CL118 HEK-293T C1821(1.20); C437(0.95); C1934(1.13); C1698(1.27)  LDD1592  [20]
 LDCM0389  CL119 HEK-293T C437(0.96); C1934(1.08); C1698(0.99)  LDD1593  [20]
 LDCM0390  CL12 HEK-293T C1821(1.21); C437(0.90); C1934(1.00); C1698(1.09)  LDD1594  [20]
 LDCM0391  CL120 HEK-293T C437(0.91); C1934(1.19)  LDD1595  [20]
 LDCM0392  CL121 HEK-293T C1821(0.94); C1934(0.99)  LDD0990  [19]
 LDCM0393  CL122 HEK-293T C1821(0.92); C1934(1.03)  LDD0991  [19]
 LDCM0394  CL123 HEK-293T C1821(0.82); C1934(1.06)  LDD0992  [19]
 LDCM0395  CL124 HEK-293T C1821(0.83); C1934(1.00)  LDD0993  [19]
 LDCM0396  CL125 HEK-293T C1821(0.80); C437(0.88); C1934(0.97); C1698(0.94)  LDD1600  [20]
 LDCM0397  CL126 HEK-293T C1821(1.14); C437(1.01); C1934(0.98); C1698(1.20)  LDD1601  [20]
 LDCM0398  CL127 HEK-293T C437(0.99); C1934(1.23); C1698(1.25)  LDD1602  [20]
 LDCM0399  CL128 HEK-293T C437(0.94); C1934(1.18)  LDD1603  [20]
 LDCM0400  CL13 HEK-293T C1821(0.99); C437(1.04); C1934(0.95); C1698(0.90)  LDD1604  [20]
 LDCM0401  CL14 HEK-293T C1821(1.19); C437(0.98); C1934(1.16); C1698(1.56)  LDD1605  [20]
 LDCM0402  CL15 HEK-293T C437(0.93); C1934(0.93); C1698(1.26)  LDD1606  [20]
 LDCM0403  CL16 HEK-293T C437(0.91); C1934(0.97)  LDD1607  [20]
 LDCM0404  CL17 HEK-293T C1821(1.02); C437(0.99); C1934(1.01)  LDD1608  [20]
 LDCM0405  CL18 HEK-293T C437(1.04); C1934(0.79)  LDD1609  [20]
 LDCM0406  CL19 HEK-293T C437(0.99); C1934(0.77)  LDD1610  [20]
 LDCM0407  CL2 HEK-293T C1821(0.80); C437(0.98); C1934(1.03); C1698(1.41)  LDD1611  [20]
 LDCM0408  CL20 HEK-293T C437(1.02); C1934(1.02); C1698(1.75)  LDD1612  [20]
 LDCM0409  CL21 HEK-293T C1821(0.94); C437(0.89); C1934(0.83)  LDD1613  [20]
 LDCM0410  CL22 HEK-293T C1821(1.14); C437(1.00); C1934(1.04); C1698(1.33)  LDD1614  [20]
 LDCM0411  CL23 HEK-293T C437(1.01); C1934(1.02); C1698(1.04)  LDD1615  [20]
 LDCM0412  CL24 HEK-293T C1821(0.93); C437(0.98); C1934(1.09); C1698(0.99)  LDD1616  [20]
 LDCM0413  CL25 HEK-293T C1821(0.76); C437(0.86); C1934(0.86); C1698(0.94)  LDD1617  [20]
 LDCM0414  CL26 HEK-293T C1821(1.18); C437(1.01); C1934(0.90); C1698(1.27)  LDD1618  [20]
 LDCM0415  CL27 HEK-293T C437(1.01); C1934(1.00); C1698(1.31)  LDD1619  [20]
 LDCM0416  CL28 HEK-293T C437(0.94); C1934(0.99)  LDD1620  [20]
 LDCM0417  CL29 HEK-293T C1821(0.98); C437(1.11); C1934(0.96)  LDD1621  [20]
 LDCM0418  CL3 HEK-293T C437(0.99); C1934(0.91); C1698(1.34)  LDD1622  [20]
 LDCM0419  CL30 HEK-293T C437(1.02); C1934(0.85)  LDD1623  [20]
 LDCM0420  CL31 HEK-293T C1821(1.04); C1934(0.54)  LDD1018  [19]
 LDCM0421  CL32 HEK-293T C1821(0.99); C1934(0.61)  LDD1019  [19]
 LDCM0422  CL33 HEK-293T C1821(1.00); C1934(0.65)  LDD1020  [19]
 LDCM0423  CL34 HEK-293T C1821(0.93); C1934(0.89)  LDD1021  [19]
 LDCM0424  CL35 HEK-293T C1821(0.83); C1934(0.66)  LDD1022  [19]
 LDCM0425  CL36 HEK-293T C1821(0.83); C1934(0.78)  LDD1023  [19]
 LDCM0426  CL37 HEK-293T C1821(0.86); C1934(0.72)  LDD1024  [19]
 LDCM0428  CL39 HEK-293T C1821(0.96); C1934(0.90)  LDD1026  [19]
 LDCM0429  CL4 HEK-293T C437(0.83); C1934(1.04)  LDD1633  [20]
 LDCM0430  CL40 HEK-293T C1821(0.96); C1934(0.88)  LDD1028  [19]
 LDCM0431  CL41 HEK-293T C1821(0.85); C1934(0.73)  LDD1029  [19]
 LDCM0432  CL42 HEK-293T C1821(0.90); C1934(0.96)  LDD1030  [19]
 LDCM0433  CL43 HEK-293T C1821(0.87); C1934(1.05)  LDD1031  [19]
 LDCM0434  CL44 HEK-293T C1821(0.97); C1934(0.75)  LDD1032  [19]
 LDCM0435  CL45 HEK-293T C1821(0.85); C1934(0.77)  LDD1033  [19]
 LDCM0436  CL46 HEK-293T C1821(1.04); C437(1.00); C1934(0.89); C1698(1.18)  LDD1640  [20]
 LDCM0437  CL47 HEK-293T C437(1.05); C1934(0.99); C1698(0.91)  LDD1641  [20]
 LDCM0438  CL48 HEK-293T C1821(1.14); C437(1.10); C1934(0.97); C1698(1.18)  LDD1642  [20]
 LDCM0439  CL49 HEK-293T C1821(0.93); C437(0.90); C1934(1.04); C1698(1.18)  LDD1643  [20]
 LDCM0440  CL5 HEK-293T C1821(0.94); C437(1.14); C1934(1.10)  LDD1644  [20]
 LDCM0441  CL50 HEK-293T C1821(1.18); C437(0.93); C1934(1.12); C1698(1.62)  LDD1645  [20]
 LDCM0443  CL52 HEK-293T C437(0.92); C1934(0.95)  LDD1646  [20]
 LDCM0444  CL53 HEK-293T C1821(0.97); C437(0.95); C1934(1.03)  LDD1647  [20]
 LDCM0445  CL54 HEK-293T C437(0.91); C1934(0.73)  LDD1648  [20]
 LDCM0446  CL55 HEK-293T C437(0.95); C1934(0.81)  LDD1649  [20]
 LDCM0447  CL56 HEK-293T C437(0.88); C1934(1.00); C1698(1.51)  LDD1650  [20]
 LDCM0448  CL57 HEK-293T C1821(1.06); C437(0.91); C1934(0.96)  LDD1651  [20]
 LDCM0449  CL58 HEK-293T C1821(1.00); C437(0.99); C1934(1.09); C1698(1.34)  LDD1652  [20]
 LDCM0450  CL59 HEK-293T C437(0.97); C1934(1.05); C1698(1.20)  LDD1653  [20]
 LDCM0451  CL6 HEK-293T C437(1.01); C1934(0.82)  LDD1654  [20]
 LDCM0452  CL60 HEK-293T C1821(1.05); C437(0.96); C1934(0.98); C1698(0.97)  LDD1655  [20]
 LDCM0453  CL61 HEK-293T C1821(0.84); C437(1.00); C1934(1.04); C1698(1.12)  LDD1656  [20]
 LDCM0454  CL62 HEK-293T C1821(1.12); C437(0.97); C1934(1.24); C1698(1.83)  LDD1657  [20]
 LDCM0455  CL63 HEK-293T C437(0.96); C1934(1.03); C1698(1.21)  LDD1658  [20]
 LDCM0456  CL64 HEK-293T C437(0.86); C1934(0.99)  LDD1659  [20]
 LDCM0457  CL65 HEK-293T C1821(0.93); C437(1.07); C1934(1.06)  LDD1660  [20]
 LDCM0458  CL66 HEK-293T C437(1.01); C1934(1.10)  LDD1661  [20]
 LDCM0459  CL67 HEK-293T C437(1.02); C1934(1.02)  LDD1662  [20]
 LDCM0460  CL68 HEK-293T C437(0.94); C1934(0.90); C1698(1.78)  LDD1663  [20]
 LDCM0461  CL69 HEK-293T C1821(0.93); C437(0.87); C1934(1.15)  LDD1664  [20]
 LDCM0462  CL7 HEK-293T C437(1.01); C1934(0.96)  LDD1665  [20]
 LDCM0463  CL70 HEK-293T C1821(1.22); C437(1.05); C1934(0.89); C1698(1.03)  LDD1666  [20]
 LDCM0464  CL71 HEK-293T C437(1.11); C1934(1.00); C1698(1.10)  LDD1667  [20]
 LDCM0465  CL72 HEK-293T C1821(0.97); C437(0.92); C1934(1.11); C1698(1.24)  LDD1668  [20]
 LDCM0466  CL73 HEK-293T C1821(0.98); C437(0.99); C1934(1.01); C1698(1.20)  LDD1669  [20]
 LDCM0467  CL74 HEK-293T C1821(1.24); C437(1.03); C1934(1.23); C1698(1.28)  LDD1670  [20]
 LDCM0469  CL76 HEK-293T C437(0.96); C1934(0.92)  LDD1672  [20]
 LDCM0470  CL77 HEK-293T C1821(0.95); C437(1.01); C1934(0.97)  LDD1673  [20]
 LDCM0471  CL78 HEK-293T C437(0.95); C1934(0.80)  LDD1674  [20]
 LDCM0472  CL79 HEK-293T C437(0.91); C1934(0.86)  LDD1675  [20]
 LDCM0473  CL8 HEK-293T C437(0.77); C1934(0.81); C1698(0.98)  LDD1676  [20]
 LDCM0474  CL80 HEK-293T C437(0.95); C1934(0.92); C1698(1.03)  LDD1677  [20]
 LDCM0475  CL81 HEK-293T C1821(1.05); C437(1.01); C1934(0.88)  LDD1678  [20]
 LDCM0476  CL82 HEK-293T C1821(1.07); C437(1.02); C1934(0.85); C1698(1.12)  LDD1679  [20]
 LDCM0477  CL83 HEK-293T C437(1.01); C1934(1.09); C1698(1.11)  LDD1680  [20]
 LDCM0478  CL84 HEK-293T C1821(1.01); C437(0.93); C1934(0.75); C1698(1.00)  LDD1681  [20]
 LDCM0479  CL85 HEK-293T C1821(0.84); C437(0.93); C1934(1.13); C1698(1.15)  LDD1682  [20]
 LDCM0480  CL86 HEK-293T C1821(1.11); C437(0.92); C1934(0.95); C1698(1.10)  LDD1683  [20]
 LDCM0481  CL87 HEK-293T C437(1.00); C1934(1.22); C1698(1.10)  LDD1684  [20]
 LDCM0482  CL88 HEK-293T C437(0.85); C1934(1.34)  LDD1685  [20]
 LDCM0483  CL89 HEK-293T C1821(0.75); C437(1.05); C1934(1.19)  LDD1686  [20]
 LDCM0484  CL9 HEK-293T C1821(0.86); C437(0.93); C1934(0.85)  LDD1687  [20]
 LDCM0485  CL90 HEK-293T C437(0.80); C1934(0.66)  LDD1688  [20]
 LDCM0486  CL91 HEK-293T C1821(0.99)  LDD1084  [19]
 LDCM0487  CL92 HEK-293T C1821(0.83)  LDD1085  [19]
 LDCM0488  CL93 HEK-293T C1821(1.02)  LDD1086  [19]
 LDCM0489  CL94 HEK-293T C1821(1.06)  LDD1087  [19]
 LDCM0490  CL95 HEK-293T C1821(0.98)  LDD1088  [19]
 LDCM0491  CL96 HEK-293T C1821(0.99)  LDD1089  [19]
 LDCM0492  CL97 HEK-293T C1821(1.06)  LDD1090  [19]
 LDCM0493  CL98 HEK-293T C1821(0.86)  LDD1091  [19]
 LDCM0494  CL99 HEK-293T C1821(0.90)  LDD1092  [19]
 LDCM0191  Compound 21 HEK-293T 5.08  LDD0508  [18]
 LDCM0190  Compound 34 HEK-293T 5.51  LDD0510  [18]
 LDCM0192  Compound 35 HEK-293T 5.73  LDD0509  [18]
 LDCM0193  Compound 36 HEK-293T 8.66  LDD0511  [18]
 LDCM0495  E2913 HEK-293T C437(1.00); C1934(1.01); C1698(1.48)  LDD1698  [20]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C1821(1.05); C437(0.98)  LDD1702  [22]
 LDCM0031  Epigallocatechin gallate HEK-293T 5.70  LDD0183  [7]
 LDCM0625  F8 Ramos C486(1.12)  LDD2187  [23]
 LDCM0572  Fragment10 Ramos C486(2.21)  LDD2189  [23]
 LDCM0574  Fragment12 Ramos C486(0.87)  LDD2191  [23]
 LDCM0575  Fragment13 Ramos C486(0.97)  LDD2192  [23]
 LDCM0576  Fragment14 Ramos C486(0.78)  LDD2193  [23]
 LDCM0579  Fragment20 Ramos C486(0.94)  LDD2194  [23]
 LDCM0580  Fragment21 Ramos C486(1.25)  LDD2195  [23]
 LDCM0582  Fragment23 Ramos C486(2.25)  LDD2196  [23]
 LDCM0578  Fragment27 Ramos C486(1.46)  LDD2197  [23]
 LDCM0586  Fragment28 Ramos C486(0.47)  LDD2198  [23]
 LDCM0588  Fragment30 Ramos C486(1.52)  LDD2199  [23]
 LDCM0589  Fragment31 Ramos C486(0.92)  LDD2200  [23]
 LDCM0590  Fragment32 Ramos C486(3.43)  LDD2201  [23]
 LDCM0468  Fragment33 HEK-293T C437(1.05); C1934(1.10); C1698(1.01)  LDD1671  [20]
 LDCM0596  Fragment38 Ramos C486(0.96)  LDD2203  [23]
 LDCM0566  Fragment4 Ramos C486(1.00)  LDD2184  [23]
 LDCM0427  Fragment51 HEK-293T C1821(0.78); C1934(0.75)  LDD1025  [19]
 LDCM0610  Fragment52 Ramos C486(1.25)  LDD2204  [23]
 LDCM0614  Fragment56 Ramos C486(1.35)  LDD2205  [23]
 LDCM0569  Fragment7 Ramos C486(1.80)  LDD2186  [23]
 LDCM0571  Fragment9 Ramos C486(1.28)  LDD2188  [23]
 LDCM0022  KB02 HEK-293T C1821(0.92); C437(0.99); C1934(1.06)  LDD1492  [20]
 LDCM0023  KB03 HEK-293T C1821(1.07); C437(1.00); C1934(0.92)  LDD1497  [20]
 LDCM0024  KB05 SH4 C437(2.72)  LDD3321  [6]
 LDCM0030  Luteolin HEK-293T 4.75  LDD0182  [7]
 LDCM0032  Oleacein HEK-293T 4.14  LDD0184  [7]
 LDCM0029  Quercetin HEK-293T 4.90  LDD0181  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcription factor Jun (JUN) BZIP family P05412
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
7 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
15 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
16 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
17 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
18 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
19 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
20 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
21 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
22 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
23 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578