Details of the Target

General Information of Target

Target ID LDTP05172
Target Name TATA element modulatory factor (TMF1)
Gene Name TMF1
Gene ID 7110
Synonyms
ARA160; TATA element modulatory factor; TMF; Androgen receptor coactivator 160 kDa protein; Androgen receptor-associated protein of 160 kDa
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSWFNASQLSSFAKQALSQAQKSIDRVLDIQEEEPSIWAETIPYGEPGISSPVSGGWDTS
TWGLKSNTEPQSPPIASPKAITKPVRRTVVDESENFFSAFLSPTDVQTIQKSPVVSKPPA
KSQRPEEEVKSSLHESLHIGQSRTPETTESQVKDSSLCVSGETLAAGTSSPKTEGKHEET
VNKESDMKVPTVSLKVSESVIDVKTTMESISNTSTQSLTAETKDIALEPKEQKHEDRQSN
TPSPPVSTFSSGTSTTSDIEVLDHESVISESSASSRQETTDSKSSLHLMQTSFQLLSASA
CPEYNRLDDFQKLTESCCSSDAFERIDSFSVQSLDSRSVSEINSDDELSGKGYALVPIIV
NSSTPKSKTVESAEGKSEEVNETLVIPTEEAEMEESGRSATPVNCEQPDILVSSTPINEG
QTVLDKVAEQCEPAESQPEALSEKEDVCKTVEFLNEKLEKREAQLLSLSKEKALLEEAFD
NLKDEMFRVKEESSSISSLKDEFTQRIAEAEKKVQLACKERDAAKKEIKNIKEELATRLN
SSETADLLKEKDEQIRGLMEEGEKLSKQQLHNSNIIKKLRAKDKENENMVAKLNKKVKEL
EEELQHLKQVLDGKEEVEKQHRENIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAAL
DSAYKELTDLHKANAAKDSEAQEAALSREMKAKEELSAALEKAQEEARQQQETLAIQVGD
LRLALQRTEQAAARKEDYLRHEIGELQQRLQEAENRNQELSQSVSSTTRPLLRQIENLQA
TLGSQTSSWEKLEKNLSDRLGESQTLLAAAVERERAATEELLANKIQMSSMESQNSLLRQ
ENSRFQAQLESEKNRLCKLEDENNRYQVELENLKDEYVRTLEETRKEKTLLNSQLEMERM
KVEQERKKAIFTQETIKEKERKPFSVSSTPTMSRSSSISGVDMAGLQTSFLSQDESHDHS
FGPMPISANGSNLYDAVRMGAGSSIIENLQSQLKLREGEITHLQLEIGNLEKTRSIMAEE
LVKLTNQNDELEEKVKEIPKLRTQLRDLDQRYNTILQMYGEKAEEAEELRLDLEDVKNMY
KTQIDELLRQSLS
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP).
Uniprot ID
P82094
Ensemble ID
ENST00000398559.7
HGNC ID
HGNC:11870

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2780 SNV: p.V339I DBIA    Probe Info 
AN3CA SNV: p.Q216Ter DBIA    Probe Info 
FUOV1 SNV: p.H138Q DBIA    Probe Info 
HCT15 SNV: p.G397E DBIA    Probe Info 
HUPT4 SNV: p.K1012T DBIA    Probe Info 
KYSE180 SNV: p.K702N DBIA    Probe Info 
KYSE410 SNV: p.E1037K DBIA    Probe Info 
NCIH1793 Deletion: p.S72_K79del .
NCIH2291 SNV: p.D678Y DBIA    Probe Info 
SKMEL2 SNV: p.Y738H DBIA    Probe Info 
TE4 SNV: p.N240Y DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C-Sul
 Probe Info  		5.24  LDD0066  [1]
STPyne
 Probe Info  		K512(9.09)  LDD0277  [2]
Probe 1
 Probe Info  		Y664(11.58)  LDD3495  [3]
m-APA
 Probe Info  		12.08  LDD0403  [4]
DBIA
 Probe Info  		C158(1.05)  LDD3310  [5]
BTD
 Probe Info  		C518(0.83)  LDD1700  [6]
DA-P3
 Probe Info  		13.16  LDD0180  [7]
AHL-Pu-1
 Probe Info  		C448(5.24)  LDD0168  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [9]
NAIA_4
 Probe Info  		N.A.  LDD2226  [10]
NAIA_5
 Probe Info  		N.A.  LDD2225  [10]
1d-yne
 Probe Info  		N.A.  LDD0356  [11]
IPM
 Probe Info  		C158(0.00); C518(0.00)  LDD0147  [12]
VSF
 Probe Info  		N.A.  LDD0007  [13]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [14]
Acrolein
 Probe Info  		C158(0.00); C318(0.00)  LDD0217  [15]
Methacrolein
 Probe Info  		N.A.  LDD0218  [15]
AOyne
 Probe Info  		13.50  LDD0443  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C518(1.03)  LDD2152  [6]
 LDCM0025  4SU-RNA HEK-293T C448(5.24)  LDD0168  [8]
 LDCM0026  4SU-RNA+native RNA HEK-293T C448(2.50)  LDD0169  [8]
 LDCM0214  AC1 HEK-293T C518(1.22); C431(1.02); C158(1.02); C318(1.02)  LDD1507  [17]
 LDCM0215  AC10 HEK-293T C518(1.23); C431(0.87); C158(0.98); C318(0.83)  LDD1508  [17]
 LDCM0226  AC11 HEK-293T C518(1.07); C431(1.09); C158(1.06); C318(1.07)  LDD1509  [17]
 LDCM0237  AC12 HEK-293T C518(1.15); C431(0.95); C158(0.99); C318(0.99)  LDD1510  [17]
 LDCM0259  AC14 HEK-293T C431(1.13); C158(1.03)  LDD1512  [17]
 LDCM0270  AC15 HEK-293T C518(1.06); C431(1.04); C158(1.01)  LDD1513  [17]
 LDCM0276  AC17 HEK-293T C518(1.19); C431(0.97); C158(1.01); C318(0.91)  LDD1515  [17]
 LDCM0277  AC18 HEK-293T C518(1.08); C431(0.96); C158(0.96); C318(0.83)  LDD1516  [17]
 LDCM0278  AC19 HEK-293T C518(0.96); C431(1.45); C158(0.99); C318(0.95)  LDD1517  [17]
 LDCM0279  AC2 HEK-293T C518(1.21); C431(0.95); C158(1.02); C318(0.98)  LDD1518  [17]
 LDCM0280  AC20 HEK-293T C518(1.22); C431(0.97); C158(0.97); C318(0.99)  LDD1519  [17]
 LDCM0281  AC21 HEK-293T C518(1.01); C431(0.99); C158(0.87); C318(1.08)  LDD1520  [17]
 LDCM0282  AC22 HEK-293T C431(0.95); C158(0.96)  LDD1521  [17]
 LDCM0283  AC23 HEK-293T C518(1.10); C431(0.96); C158(1.03)  LDD1522  [17]
 LDCM0284  AC24 HEK-293T C518(1.04); C431(1.00); C158(0.97); C301(1.16)  LDD1523  [17]
 LDCM0285  AC25 HEK-293T C518(1.18); C431(0.95); C158(0.99); C318(1.07)  LDD1524  [17]
 LDCM0286  AC26 HEK-293T C518(1.10); C431(0.92); C158(0.98); C318(0.88)  LDD1525  [17]
 LDCM0287  AC27 HEK-293T C518(1.10); C431(1.01); C158(0.99); C318(1.01)  LDD1526  [17]
 LDCM0288  AC28 HEK-293T C518(1.11); C431(0.91); C158(0.98); C318(1.16)  LDD1527  [17]
 LDCM0289  AC29 HEK-293T C518(1.32); C431(1.10); C158(0.96); C318(1.12)  LDD1528  [17]
 LDCM0290  AC3 HEK-293T C518(1.11); C431(1.02); C158(1.02); C318(0.97)  LDD1529  [17]
 LDCM0291  AC30 HEK-293T C431(0.81); C158(0.99)  LDD1530  [17]
 LDCM0292  AC31 HEK-293T C518(1.07); C431(0.99); C158(0.93)  LDD1531  [17]
 LDCM0293  AC32 HEK-293T C518(1.04); C431(0.98); C158(0.94); C301(1.03)  LDD1532  [17]
 LDCM0294  AC33 HEK-293T C518(1.22); C431(1.02); C158(1.01); C318(1.01)  LDD1533  [17]
 LDCM0295  AC34 HEK-293T C518(1.19); C431(0.86); C158(1.01); C318(1.15)  LDD1534  [17]
 LDCM0296  AC35 HEK-293T C518(1.25); C431(1.13); C158(1.04); C318(1.13)  LDD1535  [17]
 LDCM0297  AC36 HEK-293T C518(1.31); C431(1.03); C158(1.00); C318(1.30)  LDD1536  [17]
 LDCM0298  AC37 HEK-293T C518(1.16); C431(0.99); C158(0.92); C318(1.17)  LDD1537  [17]
 LDCM0299  AC38 HEK-293T C431(1.25); C158(1.03)  LDD1538  [17]
 LDCM0300  AC39 HEK-293T C518(1.05); C431(1.02); C158(0.97)  LDD1539  [17]
 LDCM0301  AC4 HEK-293T C518(1.18); C431(0.96); C158(0.96); C318(0.97)  LDD1540  [17]
 LDCM0302  AC40 HEK-293T C518(1.01); C431(1.01); C158(0.97); C301(0.92)  LDD1541  [17]
 LDCM0303  AC41 HEK-293T C518(1.15); C431(0.94); C158(1.00); C318(0.98)  LDD1542  [17]
 LDCM0304  AC42 HEK-293T C518(1.17); C431(0.86); C158(1.03); C318(1.14)  LDD1543  [17]
 LDCM0305  AC43 HEK-293T C518(1.09); C431(0.95); C158(1.10); C318(1.13)  LDD1544  [17]
 LDCM0306  AC44 HEK-293T C518(1.21); C431(0.98); C158(1.01); C318(1.12)  LDD1545  [17]
 LDCM0307  AC45 HEK-293T C518(1.19); C431(1.04); C158(0.98); C318(1.14)  LDD1546  [17]
 LDCM0308  AC46 HEK-293T C431(0.94); C158(1.00)  LDD1547  [17]
 LDCM0309  AC47 HEK-293T C518(1.02); C431(1.11); C158(1.01)  LDD1548  [17]
 LDCM0310  AC48 HEK-293T C518(0.97); C431(0.98); C158(1.01); C301(1.04)  LDD1549  [17]
 LDCM0311  AC49 HEK-293T C518(1.19); C431(0.96); C158(0.99); C318(0.96)  LDD1550  [17]
 LDCM0312  AC5 HEK-293T C518(1.52); C431(0.99); C158(0.93); C318(1.02)  LDD1551  [17]
 LDCM0313  AC50 HEK-293T C518(1.15); C431(0.92); C158(1.06); C318(0.95)  LDD1552  [17]
 LDCM0314  AC51 HEK-293T C518(1.25); C431(1.02); C158(1.03); C318(1.02)  LDD1553  [17]
 LDCM0315  AC52 HEK-293T C518(1.17); C431(0.99); C158(1.08); C318(0.83)  LDD1554  [17]
 LDCM0316  AC53 HEK-293T C518(1.32); C431(1.02); C158(0.99); C318(0.92)  LDD1555  [17]
 LDCM0317  AC54 HEK-293T C431(0.96); C158(1.01)  LDD1556  [17]
 LDCM0318  AC55 HEK-293T C518(1.03); C431(1.03); C158(0.98)  LDD1557  [17]
 LDCM0319  AC56 HEK-293T C518(0.99); C431(1.03); C158(1.02); C301(1.21)  LDD1558  [17]
 LDCM0320  AC57 HEK-293T C518(1.22); C431(1.01); C158(1.00); C318(1.04)  LDD1559  [17]
 LDCM0321  AC58 HEK-293T C518(1.17); C431(0.95); C158(0.93); C318(0.90)  LDD1560  [17]
 LDCM0322  AC59 HEK-293T C518(1.24); C431(1.19); C158(1.08); C318(1.03)  LDD1561  [17]
 LDCM0323  AC6 HEK-293T C431(0.94); C158(0.97)  LDD1562  [17]
 LDCM0324  AC60 HEK-293T C518(1.23); C431(0.99); C158(0.97); C318(1.19)  LDD1563  [17]
 LDCM0325  AC61 HEK-293T C518(1.38); C431(1.00); C158(0.96); C318(1.09)  LDD1564  [17]
 LDCM0326  AC62 HEK-293T C431(0.96); C158(1.00)  LDD1565  [17]
 LDCM0327  AC63 HEK-293T C518(1.09); C431(1.03); C158(0.98)  LDD1566  [17]
 LDCM0328  AC64 HEK-293T C518(1.02); C431(0.95); C158(1.00); C301(0.99)  LDD1567  [17]
 LDCM0334  AC7 HEK-293T C518(1.14); C431(1.10); C158(1.02)  LDD1568  [17]
 LDCM0345  AC8 HEK-293T C518(1.06); C431(1.02); C158(0.95); C301(1.09)  LDD1569  [17]
 LDCM0248  AKOS034007472 HEK-293T C518(1.24); C431(0.97); C158(0.94); C318(1.29)  LDD1511  [17]
 LDCM0356  AKOS034007680 HEK-293T C518(1.15); C431(1.05); C158(1.05); C318(1.06)  LDD1570  [17]
 LDCM0275  AKOS034007705 HEK-293T C518(0.97); C431(1.06); C158(1.00); C301(1.06)  LDD1514  [17]
 LDCM0156  Aniline NCI-H1299 12.08  LDD0403  [4]
 LDCM0087  Capsaicin HEK-293T 37.96  LDD0185  [7]
 LDCM0108  Chloroacetamide HeLa C158(0.00); C318(0.00)  LDD0222  [15]
 LDCM0367  CL1 HEK-293T C518(0.94); C431(0.93); C158(0.95); C301(1.05)  LDD1571  [17]
 LDCM0368  CL10 HEK-293T C431(1.09); C158(0.83)  LDD1572  [17]
 LDCM0369  CL100 HEK-293T C518(1.15); C431(0.98); C158(0.97); C318(0.92)  LDD1573  [17]
 LDCM0370  CL101 HEK-293T C518(1.33); C431(0.97); C158(1.00); C301(1.10)  LDD1574  [17]
 LDCM0371  CL102 HEK-293T C518(0.97); C431(1.14); C158(0.97); C318(0.93)  LDD1575  [17]
 LDCM0372  CL103 HEK-293T C518(1.24); C431(1.03); C158(0.98); C405(1.00)  LDD1576  [17]
 LDCM0373  CL104 HEK-293T C518(1.04); C431(0.90); C158(1.00); C318(1.04)  LDD1577  [17]
 LDCM0374  CL105 HEK-293T C518(1.17); C431(1.05); C158(0.94); C301(0.99)  LDD1578  [17]
 LDCM0375  CL106 HEK-293T C518(0.94); C431(1.01); C158(0.95); C318(0.93)  LDD1579  [17]
 LDCM0376  CL107 HEK-293T C518(1.15); C431(1.03); C158(0.93); C405(1.00)  LDD1580  [17]
 LDCM0377  CL108 HEK-293T C518(1.15); C431(1.01); C158(1.05); C318(1.12)  LDD1581  [17]
 LDCM0378  CL109 HEK-293T C518(0.99); C431(0.98); C158(0.94); C301(1.00)  LDD1582  [17]
 LDCM0379  CL11 HEK-293T C518(0.70); C431(0.98); C158(1.00)  LDD1583  [17]
 LDCM0380  CL110 HEK-293T C518(0.93); C431(0.98); C158(0.92); C318(0.98)  LDD1584  [17]
 LDCM0381  CL111 HEK-293T C518(1.11); C431(0.99); C158(0.97); C405(0.92)  LDD1585  [17]
 LDCM0382  CL112 HEK-293T C518(1.12); C431(1.04); C158(0.94); C318(0.90)  LDD1586  [17]
 LDCM0383  CL113 HEK-293T C518(1.19); C431(1.01); C158(0.95); C301(0.92)  LDD1587  [17]
 LDCM0384  CL114 HEK-293T C518(0.95); C431(1.06); C158(0.92); C318(0.82)  LDD1588  [17]
 LDCM0385  CL115 HEK-293T C518(1.22); C431(0.93); C158(0.97); C405(1.23)  LDD1589  [17]
 LDCM0386  CL116 HEK-293T C518(1.19); C431(0.96); C158(0.95); C318(1.13)  LDD1590  [17]
 LDCM0387  CL117 HEK-293T C518(1.17); C431(0.94); C158(0.88); C301(1.12)  LDD1591  [17]
 LDCM0388  CL118 HEK-293T C518(1.03); C431(1.11); C158(0.97); C318(0.82)  LDD1592  [17]
 LDCM0389  CL119 HEK-293T C518(1.16); C431(0.94); C158(0.98); C405(1.12)  LDD1593  [17]
 LDCM0390  CL12 HEK-293T C518(0.62); C431(1.28); C158(1.00); C301(0.91)  LDD1594  [17]
 LDCM0391  CL120 HEK-293T C518(1.14); C431(0.96); C158(0.95); C318(1.06)  LDD1595  [17]
 LDCM0392  CL121 HEK-293T C518(1.28); C431(1.05); C158(0.97); C301(1.05)  LDD1596  [17]
 LDCM0393  CL122 HEK-293T C518(1.07); C431(1.06); C158(1.08); C318(0.88)  LDD1597  [17]
 LDCM0394  CL123 HEK-293T C518(1.09); C431(1.02); C158(0.88); C405(0.81)  LDD1598  [17]
 LDCM0395  CL124 HEK-293T C518(1.12); C431(0.90); C158(0.99); C318(1.02)  LDD1599  [17]
 LDCM0396  CL125 HEK-293T C518(1.18); C431(0.99); C158(1.03); C301(0.92)  LDD1600  [17]
 LDCM0397  CL126 HEK-293T C518(1.06); C431(1.11); C158(0.98); C318(0.72)  LDD1601  [17]
 LDCM0398  CL127 HEK-293T C518(1.27); C431(1.06); C158(0.99); C405(1.13)  LDD1602  [17]
 LDCM0399  CL128 HEK-293T C518(1.13); C431(0.83); C158(0.96); C318(1.11)  LDD1603  [17]
 LDCM0400  CL13 HEK-293T C518(1.09); C431(1.11); C158(0.93); C301(0.92)  LDD1604  [17]
 LDCM0401  CL14 HEK-293T C518(0.97); C431(1.13); C158(1.05); C318(0.82)  LDD1605  [17]
 LDCM0402  CL15 HEK-293T C518(1.17); C431(0.98); C158(0.91); C405(1.05)  LDD1606  [17]
 LDCM0403  CL16 HEK-293T C518(1.01); C431(1.01); C158(1.05); C318(1.11)  LDD1607  [17]
 LDCM0404  CL17 HEK-293T C518(0.94); C431(0.91); C158(1.00); C318(1.02)  LDD1608  [17]
 LDCM0405  CL18 HEK-293T C518(1.10); C431(0.97); C158(1.06); C318(1.06)  LDD1609  [17]
 LDCM0406  CL19 HEK-293T C518(0.92); C431(1.26); C158(1.04); C318(1.17)  LDD1610  [17]
 LDCM0407  CL2 HEK-293T C518(0.96); C431(1.00); C158(1.08); C318(0.89)  LDD1611  [17]
 LDCM0408  CL20 HEK-293T C518(0.91); C431(1.01); C158(1.02); C318(1.19)  LDD1612  [17]
 LDCM0409  CL21 HEK-293T C518(0.78); C431(0.99); C158(0.99); C318(0.81)  LDD1613  [17]
 LDCM0410  CL22 HEK-293T C431(1.43); C158(0.95)  LDD1614  [17]
 LDCM0411  CL23 HEK-293T C518(0.69); C431(1.13); C158(1.00)  LDD1615  [17]
 LDCM0412  CL24 HEK-293T C518(0.57); C431(1.38); C158(0.97); C301(1.10)  LDD1616  [17]
 LDCM0413  CL25 HEK-293T C518(1.42); C431(1.01); C158(0.91); C301(0.95)  LDD1617  [17]
 LDCM0414  CL26 HEK-293T C518(1.06); C431(1.05); C158(1.02); C318(1.02)  LDD1618  [17]
 LDCM0415  CL27 HEK-293T C518(1.15); C431(1.03); C158(0.96); C405(1.04)  LDD1619  [17]
 LDCM0416  CL28 HEK-293T C518(1.08); C431(1.16); C158(0.96); C318(0.99)  LDD1620  [17]
 LDCM0417  CL29 HEK-293T C518(1.08); C431(1.03); C158(1.01); C318(1.04)  LDD1621  [17]
 LDCM0418  CL3 HEK-293T C518(1.34); C431(1.02); C158(0.93); C405(0.93)  LDD1622  [17]
 LDCM0419  CL30 HEK-293T C518(0.98); C431(1.08); C158(1.07); C318(0.89)  LDD1623  [17]
 LDCM0420  CL31 HEK-293T C518(0.86); C431(1.00); C158(0.97); C318(1.14)  LDD1624  [17]
 LDCM0421  CL32 HEK-293T C518(0.86); C431(0.98); C158(0.99); C318(1.09)  LDD1625  [17]
 LDCM0422  CL33 HEK-293T C518(0.65); C431(0.96); C158(0.92); C318(0.84)  LDD1626  [17]
 LDCM0423  CL34 HEK-293T C431(1.15); C158(0.95)  LDD1627  [17]
 LDCM0424  CL35 HEK-293T C518(0.66); C431(1.06); C158(0.92)  LDD1628  [17]
 LDCM0425  CL36 HEK-293T C518(0.58); C431(1.38); C158(0.98); C301(0.96)  LDD1629  [17]
 LDCM0426  CL37 HEK-293T C518(1.01); C431(1.08); C158(0.93); C301(0.94)  LDD1630  [17]
 LDCM0428  CL39 HEK-293T C518(1.10); C431(0.94); C158(0.91); C405(1.01)  LDD1632  [17]
 LDCM0429  CL4 HEK-293T C518(1.06); C431(0.94); C158(1.01); C318(1.10)  LDD1633  [17]
 LDCM0430  CL40 HEK-293T C518(1.07); C431(1.09); C158(1.01); C318(0.93)  LDD1634  [17]
 LDCM0431  CL41 HEK-293T C518(1.02); C431(0.97); C158(1.05); C318(0.96)  LDD1635  [17]
 LDCM0432  CL42 HEK-293T C518(0.91); C431(1.04); C158(0.96); C318(1.31)  LDD1636  [17]
 LDCM0433  CL43 HEK-293T C518(0.86); C431(1.01); C158(1.02); C318(0.96)  LDD1637  [17]
 LDCM0434  CL44 HEK-293T C518(0.86); C431(0.97); C158(1.03); C318(0.98)  LDD1638  [17]
 LDCM0435  CL45 HEK-293T C518(0.91); C431(0.97); C158(0.98); C318(1.11)  LDD1639  [17]
 LDCM0436  CL46 HEK-293T C431(1.18); C158(1.05)  LDD1640  [17]
 LDCM0437  CL47 HEK-293T C518(0.65); C431(1.03); C158(0.94)  LDD1641  [17]
 LDCM0438  CL48 HEK-293T C518(0.60); C431(1.47); C158(0.95); C301(0.95)  LDD1642  [17]
 LDCM0439  CL49 HEK-293T C518(1.18); C431(0.96); C158(0.91); C301(0.99)  LDD1643  [17]
 LDCM0440  CL5 HEK-293T C518(1.11); C431(0.93); C158(1.12); C318(1.09)  LDD1644  [17]
 LDCM0441  CL50 HEK-293T C518(1.00); C431(1.10); C158(0.94); C318(0.85)  LDD1645  [17]
 LDCM0443  CL52 HEK-293T C518(1.05); C431(0.97); C158(1.03); C318(0.99)  LDD1646  [17]
 LDCM0444  CL53 HEK-293T C518(0.95); C431(0.88); C158(0.98); C318(0.93)  LDD1647  [17]
 LDCM0445  CL54 HEK-293T C518(0.95); C431(0.91); C158(0.90); C318(0.90)  LDD1648  [17]
 LDCM0446  CL55 HEK-293T C518(0.85); C431(1.06); C158(1.05); C318(1.15)  LDD1649  [17]
 LDCM0447  CL56 HEK-293T C518(0.85); C431(1.04); C158(1.01); C318(1.15)  LDD1650  [17]
 LDCM0448  CL57 HEK-293T C518(0.91); C431(1.09); C158(1.00); C318(0.81)  LDD1651  [17]
 LDCM0449  CL58 HEK-293T C431(1.22); C158(0.89)  LDD1652  [17]
 LDCM0450  CL59 HEK-293T C518(0.69); C431(1.09); C158(0.99)  LDD1653  [17]
 LDCM0451  CL6 HEK-293T C518(1.09); C431(0.89); C158(0.94); C318(1.01)  LDD1654  [17]
 LDCM0452  CL60 HEK-293T C518(0.59); C431(1.33); C158(1.03); C301(1.06)  LDD1655  [17]
 LDCM0453  CL61 HEK-293T C518(1.36); C431(1.05); C158(0.92); C301(1.02)  LDD1656  [17]
 LDCM0454  CL62 HEK-293T C518(1.10); C431(1.12); C158(1.11); C318(0.88)  LDD1657  [17]
 LDCM0455  CL63 HEK-293T C518(1.16); C431(0.98); C158(0.99); C405(1.04)  LDD1658  [17]
 LDCM0456  CL64 HEK-293T C518(1.01); C431(0.83); C158(0.95); C318(0.89)  LDD1659  [17]
 LDCM0457  CL65 HEK-293T C518(1.08); C431(1.02); C158(1.06); C318(1.18)  LDD1660  [17]
 LDCM0458  CL66 HEK-293T C518(0.99); C431(0.89); C158(1.01); C318(1.03)  LDD1661  [17]
 LDCM0459  CL67 HEK-293T C518(0.91); C431(1.00); C158(1.09); C318(1.02)  LDD1662  [17]
 LDCM0460  CL68 HEK-293T C518(0.87); C431(0.96); C158(0.94); C318(1.74)  LDD1663  [17]
 LDCM0461  CL69 HEK-293T C518(0.95); C431(0.97); C158(0.92); C318(1.00)  LDD1664  [17]
 LDCM0462  CL7 HEK-293T C518(0.99); C431(1.29); C158(1.04); C318(1.12)  LDD1665  [17]
 LDCM0463  CL70 HEK-293T C431(1.11); C158(1.00)  LDD1666  [17]
 LDCM0464  CL71 HEK-293T C518(0.66); C431(1.06); C158(0.93)  LDD1667  [17]
 LDCM0465  CL72 HEK-293T C518(0.64); C431(1.29); C158(0.99); C301(1.02)  LDD1668  [17]
 LDCM0466  CL73 HEK-293T C518(1.14); C431(0.98); C158(0.94); C301(1.14)  LDD1669  [17]
 LDCM0467  CL74 HEK-293T C518(1.04); C431(1.19); C158(1.02); C318(0.93)  LDD1670  [17]
 LDCM0469  CL76 HEK-293T C518(1.13); C431(1.13); C158(0.91); C318(1.17)  LDD1672  [17]
 LDCM0470  CL77 HEK-293T C518(0.93); C431(0.93); C158(0.95); C318(1.00)  LDD1673  [17]
 LDCM0471  CL78 HEK-293T C518(1.05); C431(0.94); C158(1.08); C318(1.20)  LDD1674  [17]
 LDCM0472  CL79 HEK-293T C518(0.91); C431(1.05); C158(0.97); C318(1.08)  LDD1675  [17]
 LDCM0473  CL8 HEK-293T C518(0.65); C431(0.92); C158(0.77); C318(0.99)  LDD1676  [17]
 LDCM0474  CL80 HEK-293T C518(0.83); C431(1.03); C158(1.04); C318(1.13)  LDD1677  [17]
 LDCM0475  CL81 HEK-293T C518(0.86); C431(0.99); C158(0.98); C318(1.01)  LDD1678  [17]
 LDCM0476  CL82 HEK-293T C431(1.02); C158(1.03)  LDD1679  [17]
 LDCM0477  CL83 HEK-293T C518(0.68); C431(0.97); C158(0.91)  LDD1680  [17]
 LDCM0478  CL84 HEK-293T C518(0.66); C431(1.25); C158(0.96); C301(0.96)  LDD1681  [17]
 LDCM0479  CL85 HEK-293T C518(1.19); C431(1.04); C158(0.98); C301(1.10)  LDD1682  [17]
 LDCM0480  CL86 HEK-293T C518(1.27); C431(1.12); C158(0.96); C318(0.71)  LDD1683  [17]
 LDCM0481  CL87 HEK-293T C518(1.30); C431(1.14); C158(0.95); C405(1.05)  LDD1684  [17]
 LDCM0482  CL88 HEK-293T C518(1.31); C431(0.89); C158(1.01); C318(1.17)  LDD1685  [17]
 LDCM0483  CL89 HEK-293T C518(1.25); C431(0.99); C158(1.03); C318(1.10)  LDD1686  [17]
 LDCM0484  CL9 HEK-293T C518(0.81); C431(1.00); C158(1.02); C318(0.94)  LDD1687  [17]
 LDCM0485  CL90 HEK-293T C518(0.95); C431(0.67); C158(0.89); C318(1.03)  LDD1688  [17]
 LDCM0486  CL91 HEK-293T C518(1.04); C431(1.19); C158(0.97); C318(1.09)  LDD1689  [17]
 LDCM0487  CL92 HEK-293T C518(1.03); C431(0.95); C158(0.95); C318(1.13)  LDD1690  [17]
 LDCM0488  CL93 HEK-293T C518(0.94); C431(1.02); C158(0.96); C318(1.02)  LDD1691  [17]
 LDCM0489  CL94 HEK-293T C431(1.08); C158(0.97)  LDD1692  [17]
 LDCM0490  CL95 HEK-293T C518(0.71); C431(0.90); C158(0.90)  LDD1693  [17]
 LDCM0491  CL96 HEK-293T C518(0.84); C431(1.23); C158(1.05); C301(0.96)  LDD1694  [17]
 LDCM0492  CL97 HEK-293T C518(1.20); C431(0.97); C158(0.93); C301(1.21)  LDD1695  [17]
 LDCM0493  CL98 HEK-293T C518(1.01); C431(1.03); C158(1.01); C318(0.92)  LDD1696  [17]
 LDCM0494  CL99 HEK-293T C518(1.14); C431(0.96); C158(0.96); C405(1.14)  LDD1697  [17]
 LDCM0028  Dobutamine HEK-293T 13.16  LDD0180  [7]
 LDCM0495  E2913 HEK-293T C518(1.16); C431(0.99); C158(0.96); C405(1.10)  LDD1698  [17]
 LDCM0031  Epigallocatechin gallate HEK-293T 16.65  LDD0183  [7]
 LDCM0468  Fragment33 HEK-293T C518(1.23); C431(1.07); C158(0.95); C405(1.04)  LDD1671  [17]
 LDCM0427  Fragment51 HEK-293T C518(1.05); C431(1.07); C158(0.96); C318(0.88)  LDD1631  [17]
 LDCM0022  KB02 HEK-293T C518(1.00); C431(0.96); C158(0.97); C318(1.04)  LDD1492  [17]
 LDCM0023  KB03 HEK-293T C518(0.88); C431(0.99); C158(0.99); C318(0.91)  LDD1497  [17]
 LDCM0024  KB05 COLO792 C158(1.05)  LDD3310  [5]
 LDCM0030  Luteolin HEK-293T 31.02  LDD0182  [7]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C518(2.06)  LDD2119  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C518(1.27)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C518(1.01)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C518(0.79)  LDD2137  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C518(0.83)  LDD1700  [6]
 LDCM0029  Quercetin HEK-293T 19.16  LDD0181  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glucocorticoid receptor (NR3C1) Nuclear hormone receptor family P04150

References

1 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
15 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402