Details of the Target

General Information of Target

Target ID LDTP19838
Target Name Immunity-related GTPase family Q protein (IRGQ)
Gene Name IRGQ
Gene ID 126298
Synonyms
IRGQ1; Immunity-related GTPase family Q protein
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MASVPSIGCLLARNQYYRKSSVSSVSSLTSSDSVNFIDDDKPQQGLPEVAESTWWFKSFF
HSEPVLSNVRIKDLSATGSLSGRS
Target Bioclass
Enzyme
Family
TRAFAC class dynamin-like GTPase superfamily, IRG family
Uniprot ID
Q8WZA9
Ensemble ID
ENST00000422989.6
HGNC ID
HGNC:24868

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.98  LDD0402  [1]
DAyne
 Probe Info  		2.09  LDD0261  [2]
BTD
 Probe Info  		C373(1.10)  LDD2089  [3]
DA-P3
 Probe Info  		10.41  LDD0179  [4]
AHL-Pu-1
 Probe Info  		C328(20.00)  LDD0168  [5]
DBIA
 Probe Info  		C373(2.04)  LDD0080  [6]
W1
 Probe Info  		C340(0.82)  LDD0239  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C504(0.00); C340(0.00); C443(0.00); C373(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		C443(0.00); C504(0.00); C28(0.00)  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		C443(0.00); C504(0.00); C340(0.00); C28(0.00)  LDD0037  [8]
NAIA_4
 Probe Info  		N.A.  LDD2226  [9]
1d-yne
 Probe Info  		N.A.  LDD0356  [10]
IPM
 Probe Info  		N.A.  LDD0147  [11]
Phosphinate-6
 Probe Info  		C340(0.00); C373(0.00)  LDD0018  [12]
1c-yne
 Probe Info  		N.A.  LDD0228  [10]
Acrolein
 Probe Info  		N.A.  LDD0217  [13]
Methacrolein
 Probe Info  		N.A.  LDD0218  [13]
AOyne
 Probe Info  		13.60  LDD0443  [14]
NAIA_5
 Probe Info  		C504(0.00); C373(0.00); C28(0.00)  LDD2223  [9]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C310
 Probe Info  		8.06  LDD1977  [15]
C350
 Probe Info  		33.13  LDD2011  [15]
C354
 Probe Info  		8.00  LDD2015  [15]
VE-P
 Probe Info  		N.A.  LDD0396  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C373(0.95)  LDD2142  [3]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C373(0.67)  LDD2095  [3]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C373(0.96)  LDD2130  [3]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C373(1.06)  LDD2117  [3]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C373(0.91)  LDD2152  [3]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C373(1.11)  LDD2103  [3]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C373(0.70)  LDD2132  [3]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C373(0.60)  LDD2131  [3]
 LDCM0025  4SU-RNA HEK-293T C328(20.00)  LDD0168  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C340(2.19); C152(2.46)  LDD0169  [5]
 LDCM0214  AC1 HEK-293T C158(0.98)  LDD0812  [6]
 LDCM0215  AC10 HEK-293T C158(1.07); C373(1.73)  LDD0813  [6]
 LDCM0216  AC100 HCT 116 C152(0.94); C158(0.94)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C152(0.77); C158(0.77)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C152(0.69); C158(0.69)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C152(1.20); C158(1.20)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C152(1.15); C158(1.15)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C152(0.93); C158(0.93)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C152(1.28); C158(1.28)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C152(1.56); C158(1.10)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C152(0.76); C158(0.62)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C152(0.76); C158(0.84)  LDD0542  [6]
 LDCM0226  AC11 HEK-293T C158(0.89); C373(1.26)  LDD0824  [6]
 LDCM0227  AC110 HCT 116 C152(0.67); C158(0.82)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C152(0.69); C158(0.77)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C152(1.10); C158(0.82)  LDD0546  [6]
 LDCM0230  AC113 HEK-293T C152(1.14); C158(1.12)  LDD0828  [6]
 LDCM0231  AC114 HEK-293T C152(1.20); C158(0.98)  LDD0829  [6]
 LDCM0232  AC115 HEK-293T C152(1.20); C158(1.01)  LDD0830  [6]
 LDCM0233  AC116 HEK-293T C152(1.16); C158(1.10)  LDD0831  [6]
 LDCM0234  AC117 HEK-293T C152(1.29); C158(1.16)  LDD0832  [6]
 LDCM0235  AC118 HEK-293T C152(1.46); C158(1.14)  LDD0833  [6]
 LDCM0236  AC119 HEK-293T C152(1.22); C158(1.08)  LDD0834  [6]
 LDCM0237  AC12 HEK-293T C158(0.94); C373(0.99)  LDD0835  [6]
 LDCM0238  AC120 HEK-293T C152(1.75); C158(1.09)  LDD0836  [6]
 LDCM0239  AC121 HEK-293T C152(1.39); C158(1.09)  LDD0837  [6]
 LDCM0240  AC122 HEK-293T C152(1.92); C158(1.28)  LDD0838  [6]
 LDCM0241  AC123 HEK-293T C152(1.56); C158(1.23)  LDD0839  [6]
 LDCM0242  AC124 HEK-293T C152(1.45); C158(1.07)  LDD0840  [6]
 LDCM0243  AC125 HEK-293T C152(1.76); C158(1.17)  LDD0841  [6]
 LDCM0244  AC126 HEK-293T C152(2.04); C158(1.41)  LDD0842  [6]
 LDCM0245  AC127 HEK-293T C152(2.26); C158(1.43)  LDD0843  [6]
 LDCM0246  AC128 HEK-293T C152(1.01); C158(1.18)  LDD0844  [6]
 LDCM0247  AC129 HEK-293T C152(1.29); C158(1.14)  LDD0845  [6]
 LDCM0249  AC130 HEK-293T C152(1.22); C158(1.14)  LDD0847  [6]
 LDCM0250  AC131 HEK-293T C152(1.10); C158(1.10)  LDD0848  [6]
 LDCM0251  AC132 HEK-293T C152(1.27); C158(1.21)  LDD0849  [6]
 LDCM0252  AC133 HEK-293T C152(1.45); C158(1.27)  LDD0850  [6]
 LDCM0253  AC134 HEK-293T C152(2.09); C158(1.20)  LDD0851  [6]
 LDCM0254  AC135 HEK-293T C152(1.38); C158(1.37)  LDD0852  [6]
 LDCM0255  AC136 HEK-293T C152(1.30); C158(1.43)  LDD0853  [6]
 LDCM0256  AC137 HEK-293T C152(1.29); C158(1.35)  LDD0854  [6]
 LDCM0257  AC138 HEK-293T C152(1.47); C158(1.64)  LDD0855  [6]
 LDCM0258  AC139 HEK-293T C152(1.26); C158(1.50)  LDD0856  [6]
 LDCM0259  AC14 HEK-293T C158(0.98); C373(2.30)  LDD0857  [6]
 LDCM0260  AC140 HEK-293T C152(1.46); C158(1.30)  LDD0858  [6]
 LDCM0261  AC141 HEK-293T C152(1.44); C158(1.51)  LDD0859  [6]
 LDCM0262  AC142 HEK-293T C152(1.28); C158(1.32)  LDD0860  [6]
 LDCM0263  AC143 HEK-293T C158(1.16)  LDD0861  [6]
 LDCM0264  AC144 HEK-293T C158(1.10)  LDD0862  [6]
 LDCM0265  AC145 HEK-293T C158(1.05)  LDD0863  [6]
 LDCM0266  AC146 HEK-293T C158(1.14)  LDD0864  [6]
 LDCM0267  AC147 HEK-293T C158(1.29)  LDD0865  [6]
 LDCM0268  AC148 HEK-293T C158(1.36)  LDD0866  [6]
 LDCM0269  AC149 HEK-293T C158(0.88)  LDD0867  [6]
 LDCM0270  AC15 HEK-293T C158(1.16); C373(1.39)  LDD0868  [6]
 LDCM0271  AC150 HEK-293T C158(1.07)  LDD0869  [6]
 LDCM0272  AC151 HEK-293T C158(1.12)  LDD0870  [6]
 LDCM0273  AC152 HEK-293T C158(1.04)  LDD0871  [6]
 LDCM0274  AC153 HEK-293T C158(1.04)  LDD0872  [6]
 LDCM0621  AC154 HEK-293T C158(1.11)  LDD2162  [6]
 LDCM0622  AC155 HEK-293T C158(1.13)  LDD2163  [6]
 LDCM0623  AC156 HEK-293T C158(1.10)  LDD2164  [6]
 LDCM0624  AC157 HEK-293T C158(1.44)  LDD2165  [6]
 LDCM0276  AC17 HCT 116 C152(1.09); C158(1.09)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C152(1.65); C158(1.65)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C152(1.72); C158(1.72)  LDD0595  [6]
 LDCM0279  AC2 HEK-293T C158(1.08)  LDD0877  [6]
 LDCM0280  AC20 HCT 116 C152(1.09); C158(1.09)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C152(1.21); C158(1.21)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C152(1.08); C158(1.08)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C152(1.28); C158(1.28)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C152(1.25); C158(1.25)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C152(1.34); C158(1.34)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C152(1.34); C158(1.34)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C152(1.22); C158(1.22)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C152(1.29); C158(1.29)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C152(1.39); C158(1.39)  LDD0606  [6]
 LDCM0290  AC3 HEK-293T C158(1.05)  LDD0888  [6]
 LDCM0291  AC30 HCT 116 C152(1.62); C158(1.62)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C152(1.27); C158(1.27)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C152(1.51); C158(1.51)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C152(1.40); C158(1.40)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C152(1.93); C158(1.93)  LDD0612  [6]
 LDCM0296  AC35 HEK-293T C158(1.04)  LDD0894  [6]
 LDCM0297  AC36 HEK-293T C158(1.06)  LDD0895  [6]
 LDCM0298  AC37 HEK-293T C158(1.31)  LDD0896  [6]
 LDCM0299  AC38 HEK-293T C158(0.93)  LDD0897  [6]
 LDCM0300  AC39 HEK-293T C158(0.85)  LDD0898  [6]
 LDCM0301  AC4 HEK-293T C158(0.99)  LDD0899  [6]
 LDCM0302  AC40 HEK-293T C158(0.86)  LDD0900  [6]
 LDCM0303  AC41 HEK-293T C158(1.00)  LDD0901  [6]
 LDCM0304  AC42 HEK-293T C158(1.06)  LDD0902  [6]
 LDCM0305  AC43 HEK-293T C158(1.10)  LDD0903  [6]
 LDCM0306  AC44 HEK-293T C158(1.02)  LDD0904  [6]
 LDCM0307  AC45 HEK-293T C158(1.54)  LDD0905  [6]
 LDCM0308  AC46 HCT 116 C152(1.19); C158(1.19)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C152(1.01); C158(1.01)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C152(0.82); C158(0.82)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C152(1.25); C158(1.25)  LDD0628  [6]
 LDCM0312  AC5 HEK-293T C158(1.01)  LDD0910  [6]
 LDCM0313  AC50 HCT 116 C152(1.42); C158(1.42)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C152(0.93); C158(0.93)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C152(1.01); C158(1.01)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C152(1.41); C158(1.41)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C152(1.10); C158(1.10)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C152(1.43); C158(1.43)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C152(1.17); C158(1.17)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C152(1.43); C158(1.43)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C152(1.62); C158(1.62)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C152(1.36); C158(1.36)  LDD0639  [6]
 LDCM0323  AC6 HEK-293T C158(0.98); C373(0.89)  LDD0921  [6]
 LDCM0324  AC60 HCT 116 C152(1.20); C158(1.20)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C152(0.97); C158(0.97)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C152(1.43); C158(1.43)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C152(1.21); C158(1.21)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C152(1.28); C158(1.28)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C152(1.24); C158(1.24)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C152(1.30); C158(1.30)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C152(1.21); C158(1.21)  LDD0648  [6]
 LDCM0332  AC68 HEK-293T C158(1.08)  LDD0930  [6]
 LDCM0333  AC69 HEK-293T C158(1.16)  LDD0931  [6]
 LDCM0334  AC7 HEK-293T C158(0.98); C373(1.54)  LDD0932  [6]
 LDCM0335  AC70 HEK-293T C158(1.18)  LDD0933  [6]
 LDCM0336  AC71 HEK-293T C158(1.06)  LDD0934  [6]
 LDCM0337  AC72 HEK-293T C158(1.15)  LDD0935  [6]
 LDCM0338  AC73 HEK-293T C158(1.14)  LDD0936  [6]
 LDCM0339  AC74 HEK-293T C158(1.42)  LDD0937  [6]
 LDCM0340  AC75 HEK-293T C158(1.24)  LDD0938  [6]
 LDCM0341  AC76 HEK-293T C158(1.15)  LDD0939  [6]
 LDCM0342  AC77 HEK-293T C158(1.21)  LDD0940  [6]
 LDCM0343  AC78 HEK-293T C158(1.27)  LDD0941  [6]
 LDCM0344  AC79 HEK-293T C158(1.06)  LDD0942  [6]
 LDCM0345  AC8 HEK-293T C158(0.99); C373(2.28)  LDD0943  [6]
 LDCM0346  AC80 HEK-293T C158(1.28)  LDD0944  [6]
 LDCM0347  AC81 HEK-293T C158(1.26)  LDD0945  [6]
 LDCM0348  AC82 HEK-293T C158(1.51)  LDD0946  [6]
 LDCM0349  AC83 HEK-293T C152(1.23); C373(0.74)  LDD0947  [6]
 LDCM0350  AC84 HEK-293T C152(1.40); C373(1.09)  LDD0948  [6]
 LDCM0351  AC85 HEK-293T C152(1.42); C373(1.01)  LDD0949  [6]
 LDCM0352  AC86 HEK-293T C152(1.48); C373(1.05)  LDD0950  [6]
 LDCM0353  AC87 HEK-293T C152(1.50); C373(1.20)  LDD0951  [6]
 LDCM0354  AC88 HEK-293T C152(2.16); C373(0.81)  LDD0952  [6]
 LDCM0355  AC89 HEK-293T C152(2.32); C373(1.34)  LDD0953  [6]
 LDCM0357  AC90 HEK-293T C152(1.54); C373(0.85)  LDD0955  [6]
 LDCM0358  AC91 HEK-293T C152(1.76); C373(1.04)  LDD0956  [6]
 LDCM0359  AC92 HEK-293T C152(2.20); C373(1.07)  LDD0957  [6]
 LDCM0360  AC93 HEK-293T C152(2.70); C373(0.91)  LDD0958  [6]
 LDCM0361  AC94 HEK-293T C152(1.84); C373(1.14)  LDD0959  [6]
 LDCM0362  AC95 HEK-293T C152(1.80); C373(0.89)  LDD0960  [6]
 LDCM0363  AC96 HEK-293T C152(2.23); C373(1.27)  LDD0961  [6]
 LDCM0364  AC97 HEK-293T C152(3.04); C373(1.07)  LDD0962  [6]
 LDCM0365  AC98 HCT 116 C152(1.11); C158(1.11)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C152(0.67); C158(0.67)  LDD0683  [6]
 LDCM0545  Acetamide MDA-MB-231 C373(0.32)  LDD2138  [3]
 LDCM0248  AKOS034007472 HEK-293T C158(1.02); C373(1.23)  LDD0846  [6]
 LDCM0356  AKOS034007680 HEK-293T C158(1.13); C373(2.38)  LDD0954  [6]
 LDCM0275  AKOS034007705 HEK-293T C158(1.02); C373(1.67)  LDD0873  [6]
 LDCM0156  Aniline NCI-H1299 11.67  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C373(1.23)  LDD2091  [3]
 LDCM0087  Capsaicin HEK-293T 10.76  LDD0185  [4]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [13]
 LDCM0632  CL-Sc Hep-G2 C373(1.27); C340(1.19); C373(0.81); C28(0.74)  LDD2227  [9]
 LDCM0367  CL1 HEK-293T C158(0.76); C373(1.32)  LDD0965  [6]
 LDCM0368  CL10 HEK-293T C158(1.52); C373(1.84)  LDD0966  [6]
 LDCM0369  CL100 HEK-293T C158(1.05)  LDD0967  [6]
 LDCM0370  CL101 HEK-293T C158(1.07); C373(1.65)  LDD0968  [6]
 LDCM0371  CL102 HEK-293T C158(0.96); C373(1.47)  LDD0969  [6]
 LDCM0372  CL103 HEK-293T C158(1.03); C373(1.72)  LDD0970  [6]
 LDCM0373  CL104 HEK-293T C158(1.09); C373(1.96)  LDD0971  [6]
 LDCM0374  CL105 HCT 116 C152(1.58); C158(1.58)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C152(1.60); C158(1.60)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C152(1.38); C158(1.38)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C152(1.94); C158(1.94)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C152(1.58); C158(1.58)  LDD0695  [6]
 LDCM0379  CL11 HEK-293T C158(1.27); C373(1.45)  LDD0977  [6]
 LDCM0380  CL110 HCT 116 C152(2.50); C158(2.50)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C152(1.68); C158(1.68)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C152(1.25); C158(1.25)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C152(1.67); C158(1.67)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C152(1.62); C158(1.62)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C152(1.51); C158(1.51)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C152(1.13); C158(1.13)  LDD0703  [6]
 LDCM0387  CL117 HEK-293T C158(0.88)  LDD0985  [6]
 LDCM0388  CL118 HEK-293T C158(1.06)  LDD0986  [6]
 LDCM0389  CL119 HEK-293T C158(0.96)  LDD0987  [6]
 LDCM0390  CL12 HEK-293T C158(1.01); C373(0.98)  LDD0988  [6]
 LDCM0391  CL120 HEK-293T C158(1.04)  LDD0989  [6]
 LDCM0392  CL121 HCT 116 C152(3.65); C158(3.65)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C152(1.16); C158(1.16)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C152(2.69); C158(2.69)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C152(1.30); C158(1.30)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C152(0.97); C158(0.97)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C152(1.11); C158(1.11)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C152(1.11); C158(1.11)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C152(1.14); C158(1.14)  LDD0716  [6]
 LDCM0400  CL13 HEK-293T C158(0.95); C373(1.37)  LDD0998  [6]
 LDCM0401  CL14 HEK-293T C158(1.00); C373(1.49)  LDD0999  [6]
 LDCM0402  CL15 HEK-293T C158(1.05); C373(2.11)  LDD1000  [6]
 LDCM0403  CL16 HEK-293T C340(0.97); C443(1.35); C373(1.13)  LDD1607  [17]
 LDCM0404  CL17 HEK-293T C340(1.07); C28(1.02)  LDD1608  [17]
 LDCM0405  CL18 HEK-293T C340(1.10); C443(1.46)  LDD1609  [17]
 LDCM0406  CL19 HEK-293T C340(1.10); C443(0.80); C28(1.10)  LDD1610  [17]
 LDCM0407  CL2 HEK-293T C158(0.86); C373(0.96)  LDD1005  [6]
 LDCM0408  CL20 HEK-293T C340(1.07); C28(0.96)  LDD1612  [17]
 LDCM0409  CL21 HEK-293T C340(0.96); C443(0.78); C28(0.78)  LDD1613  [17]
 LDCM0410  CL22 HEK-293T C340(0.99); C28(1.02); C373(1.41)  LDD1614  [17]
 LDCM0411  CL23 HEK-293T C340(1.07); C28(1.14)  LDD1615  [17]
 LDCM0412  CL24 HEK-293T C340(1.01); C28(1.03)  LDD1616  [17]
 LDCM0413  CL25 HEK-293T C340(0.93); C28(0.95)  LDD1617  [17]
 LDCM0414  CL26 HEK-293T C340(1.04); C443(0.94); C28(0.97); C328(1.06)  LDD1618  [17]
 LDCM0415  CL27 HEK-293T C340(1.03); C443(0.84)  LDD1619  [17]
 LDCM0416  CL28 HEK-293T C340(1.06); C443(0.99); C373(1.05)  LDD1620  [17]
 LDCM0417  CL29 HEK-293T C340(1.07); C28(1.08)  LDD1621  [17]
 LDCM0418  CL3 HEK-293T C158(0.93); C373(1.61)  LDD1016  [6]
 LDCM0419  CL30 HEK-293T C340(1.09); C443(1.02)  LDD1623  [17]
 LDCM0420  CL31 HEK-293T C158(1.14); C373(1.16)  LDD1018  [6]
 LDCM0421  CL32 HEK-293T C158(1.26); C373(1.43)  LDD1019  [6]
 LDCM0422  CL33 HEK-293T C158(1.05); C373(1.34)  LDD1020  [6]
 LDCM0423  CL34 HEK-293T C158(1.23); C373(1.07)  LDD1021  [6]
 LDCM0424  CL35 HEK-293T C158(1.17); C373(1.11)  LDD1022  [6]
 LDCM0425  CL36 HEK-293T C158(1.23); C373(1.28)  LDD1023  [6]
 LDCM0426  CL37 HEK-293T C158(1.04); C373(1.28)  LDD1024  [6]
 LDCM0428  CL39 HEK-293T C158(1.13); C373(1.89)  LDD1026  [6]
 LDCM0429  CL4 HEK-293T C158(0.99); C373(1.74)  LDD1027  [6]
 LDCM0430  CL40 HEK-293T C158(1.36); C373(1.21)  LDD1028  [6]
 LDCM0431  CL41 HEK-293T C158(1.14); C373(1.62)  LDD1029  [6]
 LDCM0432  CL42 HEK-293T C158(1.21); C373(1.36)  LDD1030  [6]
 LDCM0433  CL43 HEK-293T C158(1.17); C373(1.58)  LDD1031  [6]
 LDCM0434  CL44 HEK-293T C158(1.21); C373(1.22)  LDD1032  [6]
 LDCM0435  CL45 HEK-293T C158(1.06); C373(1.35)  LDD1033  [6]
 LDCM0436  CL46 HEK-293T C373(1.47)  LDD1034  [6]
 LDCM0437  CL47 HEK-293T C373(1.03)  LDD1035  [6]
 LDCM0438  CL48 HEK-293T C373(1.20)  LDD1036  [6]
 LDCM0439  CL49 HEK-293T C373(1.04)  LDD1037  [6]
 LDCM0440  CL5 HEK-293T C158(1.05); C373(1.09)  LDD1038  [6]
 LDCM0441  CL50 HEK-293T C373(1.81)  LDD1039  [6]
 LDCM0442  CL51 HEK-293T C373(1.23)  LDD1040  [6]
 LDCM0443  CL52 HEK-293T C373(1.30)  LDD1041  [6]
 LDCM0444  CL53 HEK-293T C373(1.46)  LDD1042  [6]
 LDCM0445  CL54 HEK-293T C373(1.45)  LDD1043  [6]
 LDCM0446  CL55 HEK-293T C373(1.04)  LDD1044  [6]
 LDCM0447  CL56 HEK-293T C373(1.14)  LDD1045  [6]
 LDCM0448  CL57 HEK-293T C373(1.48)  LDD1046  [6]
 LDCM0449  CL58 HEK-293T C373(1.62)  LDD1047  [6]
 LDCM0450  CL59 HEK-293T C373(1.89)  LDD1048  [6]
 LDCM0451  CL6 HEK-293T C158(0.96); C373(1.37)  LDD1049  [6]
 LDCM0452  CL60 HEK-293T C373(1.68)  LDD1050  [6]
 LDCM0453  CL61 PaTu 8988t C152(1.15); C158(1.15)  LDD1332  [6]
 LDCM0454  CL62 PaTu 8988t C152(1.80); C158(1.80)  LDD1333  [6]
 LDCM0455  CL63 PaTu 8988t C152(1.74); C158(1.74)  LDD1334  [6]
 LDCM0456  CL64 PaTu 8988t C152(2.27); C158(2.27)  LDD1335  [6]
 LDCM0457  CL65 PaTu 8988t C152(1.31); C158(1.31)  LDD1336  [6]
 LDCM0458  CL66 PaTu 8988t C152(2.14); C158(2.14)  LDD1337  [6]
 LDCM0459  CL67 PaTu 8988t C152(1.65); C158(1.65)  LDD1338  [6]
 LDCM0460  CL68 PaTu 8988t C152(2.66); C158(2.66)  LDD1339  [6]
 LDCM0461  CL69 PaTu 8988t C152(3.02); C158(3.02)  LDD1340  [6]
 LDCM0462  CL7 HEK-293T C158(0.95); C373(1.23)  LDD1060  [6]
 LDCM0463  CL70 PaTu 8988t C152(1.38); C158(1.38)  LDD1342  [6]
 LDCM0464  CL71 PaTu 8988t C152(1.71); C158(1.71)  LDD1343  [6]
 LDCM0465  CL72 PaTu 8988t C152(1.20); C158(1.20)  LDD1344  [6]
 LDCM0466  CL73 PaTu 8988t C152(2.68); C158(2.68)  LDD1345  [6]
 LDCM0467  CL74 PaTu 8988t C152(1.49); C158(1.49)  LDD1346  [6]
 LDCM0469  CL76 PaTu 8988t C152(1.32); C158(1.32)  LDD1348  [6]
 LDCM0470  CL77 PaTu 8988t C152(2.38); C158(2.38)  LDD1349  [6]
 LDCM0471  CL78 PaTu 8988t C152(1.41); C158(1.41)  LDD1350  [6]
 LDCM0472  CL79 PaTu 8988t C152(1.48); C158(1.48)  LDD1351  [6]
 LDCM0473  CL8 HEK-293T C158(0.95); C373(0.60)  LDD1071  [6]
 LDCM0474  CL80 PaTu 8988t C152(1.56); C158(1.56)  LDD1353  [6]
 LDCM0475  CL81 PaTu 8988t C152(1.88); C158(1.88)  LDD1354  [6]
 LDCM0476  CL82 PaTu 8988t C152(1.63); C158(1.63)  LDD1355  [6]
 LDCM0477  CL83 PaTu 8988t C152(1.57); C158(1.57)  LDD1356  [6]
 LDCM0478  CL84 PaTu 8988t C152(2.04); C158(2.04)  LDD1357  [6]
 LDCM0479  CL85 PaTu 8988t C152(1.53); C158(1.53)  LDD1358  [6]
 LDCM0480  CL86 PaTu 8988t C152(1.72); C158(1.72)  LDD1359  [6]
 LDCM0481  CL87 PaTu 8988t C152(1.96); C158(1.96)  LDD1360  [6]
 LDCM0482  CL88 PaTu 8988t C152(1.82); C158(1.82)  LDD1361  [6]
 LDCM0483  CL89 PaTu 8988t C152(1.49); C158(1.49)  LDD1362  [6]
 LDCM0484  CL9 HEK-293T C158(0.99); C373(0.63)  LDD1082  [6]
 LDCM0485  CL90 PaTu 8988t C152(2.84); C158(2.84)  LDD1364  [6]
 LDCM0486  CL91 HEK-293T C158(0.90)  LDD1084  [6]
 LDCM0487  CL92 HEK-293T C158(0.94)  LDD1085  [6]
 LDCM0488  CL93 HEK-293T C158(1.00)  LDD1086  [6]
 LDCM0489  CL94 HEK-293T C158(1.01)  LDD1087  [6]
 LDCM0490  CL95 HEK-293T C158(1.01)  LDD1088  [6]
 LDCM0491  CL96 HEK-293T C158(1.01)  LDD1089  [6]
 LDCM0492  CL97 HEK-293T C158(0.93)  LDD1090  [6]
 LDCM0493  CL98 HEK-293T C158(0.98)  LDD1091  [6]
 LDCM0494  CL99 HEK-293T C158(1.00)  LDD1092  [6]
 LDCM0634  CY-0357 Hep-G2 C340(0.87)  LDD2228  [9]
 LDCM0027  Dopamine HEK-293T 10.41  LDD0179  [4]
 LDCM0495  E2913 HEK-293T C340(0.90); C443(0.84)  LDD1698  [17]
 LDCM0031  Epigallocatechin gallate HEK-293T 12.81  LDD0183  [4]
 LDCM0625  F8 Ramos C340(1.73); C373(1.13)  LDD2187  [18]
 LDCM0572  Fragment10 Ramos C340(2.36); C373(0.98)  LDD2189  [18]
 LDCM0573  Fragment11 Ramos C340(2.65)  LDD2190  [18]
 LDCM0574  Fragment12 Ramos C340(1.08); C373(0.69)  LDD2191  [18]
 LDCM0575  Fragment13 Ramos C340(0.99); C373(0.90)  LDD2192  [18]
 LDCM0576  Fragment14 Ramos C340(1.21)  LDD2193  [18]
 LDCM0579  Fragment20 Ramos C340(1.09); C373(0.53)  LDD2194  [18]
 LDCM0580  Fragment21 Ramos C340(1.09); C373(1.08)  LDD2195  [18]
 LDCM0582  Fragment23 Ramos C340(1.57); C373(1.26)  LDD2196  [18]
 LDCM0578  Fragment27 Ramos C340(1.22); C373(0.95)  LDD2197  [18]
 LDCM0586  Fragment28 Ramos C340(0.54); C373(0.74)  LDD2198  [18]
 LDCM0588  Fragment30 Ramos C340(1.35); C373(0.86)  LDD2199  [18]
 LDCM0589  Fragment31 Ramos C340(1.09); C373(0.96)  LDD2200  [18]
 LDCM0590  Fragment32 Ramos C340(2.49)  LDD2201  [18]
 LDCM0468  Fragment33 PaTu 8988t C152(2.34); C158(2.34)  LDD1347  [6]
 LDCM0596  Fragment38 Ramos C340(1.10); C373(0.67)  LDD2203  [18]
 LDCM0566  Fragment4 Ramos C340(1.19); C373(0.41)  LDD2184  [18]
 LDCM0427  Fragment51 HEK-293T C158(1.19); C373(1.23)  LDD1025  [6]
 LDCM0610  Fragment52 Ramos C340(1.39); C373(3.00)  LDD2204  [18]
 LDCM0614  Fragment56 Ramos C340(1.28); C373(1.70)  LDD2205  [18]
 LDCM0569  Fragment7 Ramos C340(1.25); C373(0.48)  LDD2186  [18]
 LDCM0571  Fragment9 Ramos C340(1.57); C373(0.72)  LDD2188  [18]
 LDCM0022  KB02 HCT 116 C373(2.04)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C373(1.22)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C373(1.69)  LDD0082  [6]
 LDCM0030  Luteolin HEK-293T 13.59  LDD0182  [4]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C373(0.85)  LDD2102  [3]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C373(1.10)  LDD2089  [3]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C373(1.18)  LDD2090  [3]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C373(0.83)  LDD2092  [3]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C373(1.06)  LDD2094  [3]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C373(0.85)  LDD2096  [3]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C373(1.03)  LDD2098  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C373(0.43)  LDD2099  [3]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C373(0.63)  LDD2100  [3]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C373(0.76)  LDD2101  [3]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C373(0.82)  LDD2104  [3]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C373(1.25)  LDD2105  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C373(0.71)  LDD2107  [3]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C373(0.87)  LDD2108  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C373(0.68)  LDD2109  [3]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C373(0.57)  LDD2114  [3]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C373(0.97)  LDD2116  [3]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C373(0.99)  LDD2118  [3]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C373(0.93)  LDD2120  [3]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C373(0.99)  LDD2122  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C373(0.52)  LDD2123  [3]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C373(1.16)  LDD2124  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C373(0.49)  LDD2125  [3]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C373(1.07)  LDD2126  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C373(0.94)  LDD2127  [3]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C373(0.94)  LDD2128  [3]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C373(0.59)  LDD2134  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C373(0.38)  LDD2135  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C373(0.95)  LDD2136  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C373(0.85)  LDD2137  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C373(0.46)  LDD2140  [3]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C373(0.75)  LDD2141  [3]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C373(1.38)  LDD2143  [3]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C373(1.96)  LDD2144  [3]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C373(6.46)  LDD2145  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C373(0.23)  LDD2146  [3]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C373(4.13)  LDD2147  [3]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C373(0.86)  LDD2149  [3]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C373(1.16)  LDD2151  [3]
 LDCM0032  Oleacein HEK-293T 6.70  LDD0184  [4]
 LDCM0029  Quercetin HEK-293T 5.93  LDD0181  [4]
 LDCM0131  RA190 MM1.R C340(1.36)  LDD0304  [19]
 LDCM0112  W16 Hep-G2 C340(0.82)  LDD0239  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Microtubule-associated proteins 1A/1B light chain 3A (MAP1LC3A) ATG8 family Q9H492
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) ATG8 family Q9GZQ8

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Proteome-Wide Profiling of Cellular Targets Modified by Dopamine Metabolites Using a Bio-Orthogonally Functionalized Catecholamine. ACS Chem Biol. 2021 Nov 19;16(11):2581-2594. doi: 10.1021/acschembio.1c00629. Epub 2021 Nov 2.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
13 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
16 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
19 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.