Details of the Target

General Information of Target

Target ID LDTP11530
Target Name Tether containing UBX domain for GLUT4 (ASPSCR1)
Gene Name ASPSCR1
Gene ID 79058
Synonyms
ASPL; RCC17; TUG; UBXD9; UBXN9; Tether containing UBX domain for GLUT4; Alveolar soft part sarcoma chromosomal region candidate gene 1 protein; Alveolar soft part sarcoma locus; Renal papillary cell carcinoma protein 17; UBX domain-containing protein 9
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAHYNFKKITVVPSAKDFIDLTLSKTQRKTPTVIHKHYQIHRIRHFYMRKVKFTQQNYHD
RLSQILTDFPKLDDIHPFYADLMNILYDKDHYKLALGQINIAKNLVDNVAKDYVRLMKYG
DSLYRCKQLKRAALGRMCTVIKRQKQSLEYLEQVRQHLSRLPTIDPNTRTLLLCGYPNVG
KSSFINKVTRADVDVQPYAFTTKSLFVGHMDYKYLRWQVVDTPGILDHPLEDRNTIEMQA
ITALAHLRAAVLYVMDLSEQCGHGLREQLELFQNIRPLFINKPLIVVANKCDVKRIAELS
EDDQKIFTDLQSEGFPVIETSTLTEEGVIKVKTEACDRLLAHRVETKMKGNKVNEVLNRL
HLAIPTRRDDKERPPFIPEGVVARRKRMETEESRKKRERDLELEMGDDYILDLQKYWDLM
NLSEKHDKIPEIWEGHNIADYIDPAIMKKLEELEKEEELRTAAGEYDSVSESEDEEMLEI
RQLAKQIREKKKLKILESKEKNTQGPRMPRTAKKVQRTVLEKEMRSLGVDMDDKDDAHYA
VQARRSRSITRKRKREDSAPPSSVARSGSCSRTPRDVSGLRDVKMVKKAKTMMKNAQKKM
NRLGKKGEADRHVFDMKPKHLLSGKRKAGKKDRR
Target Bioclass
Other
Subcellular location
Endomembrane system
Function
Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface. Enhances VCP methylation catalyzed by VCPKMT.
Uniprot ID
Q9BZE9
Ensemble ID
ENST00000306729.11
HGNC ID
HGNC:13825

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A101D Substitution: p.E331V DBIA    Probe Info 
CAMA1 SNV: p.S110L .
HCT116 Deletion: p.F242LfsTer21 .
HSC3 SNV: p.A95S .
Ishikawa (Heraklio) 02 ER Insertion: p.V372GfsTer137 .
MOLT4 SNV: p.C325Y IA-alkyne    Probe Info 
SW1271 SNV: p.Q55P .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K360(10.00); K364(5.00); K547(0.36)  LDD0277  [2]
DBIA
 Probe Info  		C32(1.22)  LDD3323  [3]
DA-P3
 Probe Info  		7.32  LDD0180  [4]
AHL-Pu-1
 Probe Info  		C225(2.09); C109(5.49)  LDD0169  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C174(0.00); C109(0.00); C48(0.00); C40(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		C174(0.00); C109(0.00); C40(0.00); C48(0.00)  LDD0036  [6]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [7]
Lodoacetamide azide
 Probe Info  		C174(0.00); C109(0.00); C40(0.00); C138(0.00)  LDD0037  [6]
NAIA_4
 Probe Info  		C40(0.00); C48(0.00); C109(0.00); C174(0.00)  LDD2226  [8]
IPM
 Probe Info  		N.A.  LDD0147  [9]
TFBX
 Probe Info  		N.A.  LDD0148  [9]
VSF
 Probe Info  		N.A.  LDD0007  [10]
Phosphinate-6
 Probe Info  		C224(0.00); C48(0.00); C109(0.00); C174(0.00)  LDD0018  [11]
W1
 Probe Info  		C224(0.00); C225(0.00)  LDD0236  [12]
AOyne
 Probe Info  		11.70  LDD0443  [13]
NAIA_5
 Probe Info  		C109(0.00); C48(0.00); C40(0.00)  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C40(4.66)  LDD0170  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C225(2.09); C109(5.49)  LDD0169  [5]
 LDCM0214  AC1 HEK-293T C48(0.97); C40(1.02); C109(0.88); C174(0.90)  LDD1507  [14]
 LDCM0215  AC10 HEK-293T C48(1.01); C40(1.09); C109(0.94); C174(0.93)  LDD1508  [14]
 LDCM0226  AC11 HEK-293T C48(1.05); C40(0.77); C109(0.95); C174(0.98)  LDD1509  [14]
 LDCM0237  AC12 HEK-293T C48(1.05); C40(0.99); C109(1.12); C174(0.99)  LDD1510  [14]
 LDCM0259  AC14 HEK-293T C48(1.05); C40(1.04); C109(0.90); C174(1.00)  LDD1512  [14]
 LDCM0270  AC15 HEK-293T C48(0.98); C40(1.01); C109(0.95); C174(0.93)  LDD1513  [14]
 LDCM0276  AC17 HEK-293T C48(0.99); C40(1.09); C109(0.98); C174(0.96)  LDD1515  [14]
 LDCM0277  AC18 HEK-293T C48(1.04); C40(1.03); C109(0.97); C174(0.99)  LDD1516  [14]
 LDCM0278  AC19 HEK-293T C48(0.97); C40(0.78); C109(0.97); C174(0.98)  LDD1517  [14]
 LDCM0279  AC2 HEK-293T C48(1.06); C40(0.92); C109(1.00); C174(0.89)  LDD1518  [14]
 LDCM0280  AC20 HEK-293T C48(1.04); C40(1.07); C109(1.08); C174(0.98)  LDD1519  [14]
 LDCM0281  AC21 HEK-293T C48(0.98); C40(0.90); C109(1.07); C174(0.99)  LDD1520  [14]
 LDCM0282  AC22 HEK-293T C48(1.04); C40(1.03); C109(0.86); C174(1.04)  LDD1521  [14]
 LDCM0283  AC23 HEK-293T C48(0.99); C40(1.06); C109(1.06); C174(0.97)  LDD1522  [14]
 LDCM0284  AC24 HEK-293T C48(1.01); C40(1.05); C109(1.05); C174(0.96)  LDD1523  [14]
 LDCM0285  AC25 HEK-293T C48(1.01); C40(1.04); C109(0.89); C174(0.96)  LDD1524  [14]
 LDCM0286  AC26 HEK-293T C48(1.03); C40(0.96); C109(1.05); C174(0.97)  LDD1525  [14]
 LDCM0287  AC27 HEK-293T C48(1.01); C40(0.74); C109(1.08); C174(1.03)  LDD1526  [14]
 LDCM0288  AC28 HEK-293T C48(1.02); C40(1.03); C109(1.05); C174(1.01)  LDD1527  [14]
 LDCM0289  AC29 HEK-293T C48(0.97); C40(0.98); C109(0.96); C174(0.97)  LDD1528  [14]
 LDCM0290  AC3 HEK-293T C48(1.00); C40(0.74); C109(1.10); C174(0.92)  LDD1529  [14]
 LDCM0291  AC30 HEK-293T C48(1.03); C40(0.95); C109(0.95); C174(0.97)  LDD1530  [14]
 LDCM0292  AC31 HEK-293T C48(1.00); C40(0.91); C109(1.02); C174(1.00)  LDD1531  [14]
 LDCM0293  AC32 HEK-293T C48(0.99); C40(1.14); C109(0.95); C174(0.96)  LDD1532  [14]
 LDCM0294  AC33 HEK-293T C48(0.98); C40(1.08); C109(0.97); C174(0.90)  LDD1533  [14]
 LDCM0295  AC34 HEK-293T C48(0.99); C40(1.07); C109(1.01); C174(0.92)  LDD1534  [14]
 LDCM0296  AC35 HEK-293T C48(0.97); C40(0.60); C109(1.03); C174(0.95)  LDD1535  [14]
 LDCM0297  AC36 HEK-293T C48(0.97); C40(1.14); C109(1.05); C174(0.94)  LDD1536  [14]
 LDCM0298  AC37 HEK-293T C48(0.97); C40(0.80); C109(1.16); C174(0.90)  LDD1537  [14]
 LDCM0299  AC38 HEK-293T C48(0.94); C40(0.99); C109(1.11); C174(0.90)  LDD1538  [14]
 LDCM0300  AC39 HEK-293T C48(0.99); C40(1.06); C109(1.09); C174(0.89)  LDD1539  [14]
 LDCM0301  AC4 HEK-293T C48(0.99); C40(0.91); C109(1.27); C174(0.94)  LDD1540  [14]
 LDCM0302  AC40 HEK-293T C48(0.95); C40(1.13); C109(0.92); C174(0.94)  LDD1541  [14]
 LDCM0303  AC41 HEK-293T C48(1.03); C40(1.06); C109(0.86); C174(0.91)  LDD1542  [14]
 LDCM0304  AC42 HEK-293T C48(1.01); C40(1.07); C109(1.04); C174(0.88)  LDD1543  [14]
 LDCM0305  AC43 HEK-293T C48(1.00); C40(0.78); C109(0.99); C174(1.03)  LDD1544  [14]
 LDCM0306  AC44 HEK-293T C48(1.05); C40(1.02); C109(1.04); C174(0.92)  LDD1545  [14]
 LDCM0307  AC45 HEK-293T C48(1.00); C40(0.95); C109(1.17); C174(0.94)  LDD1546  [14]
 LDCM0308  AC46 HEK-293T C48(0.99); C40(1.08); C109(1.09); C174(0.87)  LDD1547  [14]
 LDCM0309  AC47 HEK-293T C48(1.00); C40(1.06); C109(1.02); C174(0.88)  LDD1548  [14]
 LDCM0310  AC48 HEK-293T C48(0.99); C40(1.24); C109(1.10); C174(0.94)  LDD1549  [14]
 LDCM0311  AC49 HEK-293T C48(1.00); C40(1.08); C109(0.91); C174(0.96)  LDD1550  [14]
 LDCM0312  AC5 HEK-293T C48(0.98); C40(0.91); C109(0.97); C174(0.95)  LDD1551  [14]
 LDCM0313  AC50 HEK-293T C48(0.96); C40(0.97); C109(0.99); C174(0.93)  LDD1552  [14]
 LDCM0314  AC51 HEK-293T C48(1.00); C40(0.85); C109(1.04); C174(0.99)  LDD1553  [14]
 LDCM0315  AC52 HEK-293T C48(0.99); C40(1.07); C109(1.06); C174(0.96)  LDD1554  [14]
 LDCM0316  AC53 HEK-293T C48(0.96); C40(0.83); C109(1.06); C174(0.96)  LDD1555  [14]
 LDCM0317  AC54 HEK-293T C48(1.03); C40(1.03); C109(0.92); C174(0.99)  LDD1556  [14]
 LDCM0318  AC55 HEK-293T C48(1.00); C40(1.01); C109(0.99); C174(0.96)  LDD1557  [14]
 LDCM0319  AC56 HEK-293T C48(0.96); C40(1.19); C109(1.06); C174(0.93)  LDD1558  [14]
 LDCM0320  AC57 HEK-293T C48(0.98); C40(1.04); C109(1.02); C174(0.95)  LDD1559  [14]
 LDCM0321  AC58 HEK-293T C48(1.00); C40(1.17); C109(0.98); C174(0.92)  LDD1560  [14]
 LDCM0322  AC59 HEK-293T C48(0.97); C40(1.00); C109(1.00); C174(0.94)  LDD1561  [14]
 LDCM0323  AC6 HEK-293T C48(0.99); C40(1.01); C109(1.02); C174(0.93)  LDD1562  [14]
 LDCM0324  AC60 HEK-293T C48(0.99); C40(1.11); C109(1.07); C174(0.94)  LDD1563  [14]
 LDCM0325  AC61 HEK-293T C48(0.95); C40(0.84); C109(1.07); C174(0.95)  LDD1564  [14]
 LDCM0326  AC62 HEK-293T C48(1.03); C40(1.18); C109(0.89); C174(0.94)  LDD1565  [14]
 LDCM0327  AC63 HEK-293T C48(1.00); C40(1.13); C109(0.98); C174(0.85)  LDD1566  [14]
 LDCM0328  AC64 HEK-293T C48(0.99); C40(1.07); C109(1.00); C174(0.98)  LDD1567  [14]
 LDCM0334  AC7 HEK-293T C48(1.00); C40(1.05); C109(1.02); C174(0.93)  LDD1568  [14]
 LDCM0345  AC8 HEK-293T C48(0.97); C40(1.08); C109(1.12); C174(0.92)  LDD1569  [14]
 LDCM0248  AKOS034007472 HEK-293T C48(1.00); C40(0.98); C109(1.11); C174(0.99)  LDD1511  [14]
 LDCM0356  AKOS034007680 HEK-293T C48(1.01); C40(1.06); C109(0.97); C174(0.95)  LDD1570  [14]
 LDCM0275  AKOS034007705 HEK-293T C48(0.95); C40(1.06); C109(1.00); C174(0.96)  LDD1514  [14]
 LDCM0087  Capsaicin HEK-293T 23.35  LDD0185  [4]
 LDCM0630  CCW28-3 231MFP C109(2.01)  LDD2214  [15]
 LDCM0632  CL-Sc Hep-G2 C48(0.94); C224(0.71)  LDD2227  [8]
 LDCM0367  CL1 HEK-293T C48(0.95); C40(1.08); C109(0.99); C174(0.98)  LDD1571  [14]
 LDCM0368  CL10 HEK-293T C48(1.15); C40(0.98); C109(0.94); C174(0.92)  LDD1572  [14]
 LDCM0369  CL100 HEK-293T C48(1.01); C40(0.96); C109(1.17); C174(0.95)  LDD1573  [14]
 LDCM0370  CL101 HEK-293T C48(0.98); C40(0.95); C109(1.04); C174(0.98)  LDD1574  [14]
 LDCM0371  CL102 HEK-293T C48(0.98); C40(1.03); C109(0.89); C174(0.93)  LDD1575  [14]
 LDCM0372  CL103 HEK-293T C48(1.02); C40(0.90); C109(1.02); C174(0.99)  LDD1576  [14]
 LDCM0373  CL104 HEK-293T C48(1.01); C40(1.04); C109(1.07); C174(0.98)  LDD1577  [14]
 LDCM0374  CL105 HEK-293T C48(0.93); C40(0.96); C109(1.03); C174(0.99)  LDD1578  [14]
 LDCM0375  CL106 HEK-293T C48(0.94); C40(1.07); C109(0.92); C174(1.00)  LDD1579  [14]
 LDCM0376  CL107 HEK-293T C48(1.06); C40(0.97); C109(1.24); C174(1.03)  LDD1580  [14]
 LDCM0377  CL108 HEK-293T C48(1.03); C40(1.00); C109(1.12); C174(0.92)  LDD1581  [14]
 LDCM0378  CL109 HEK-293T C48(0.94); C40(0.92); C109(0.99); C174(0.94)  LDD1582  [14]
 LDCM0379  CL11 HEK-293T C48(1.00); C40(1.18); C109(0.91); C174(1.00)  LDD1583  [14]
 LDCM0380  CL110 HEK-293T C48(0.96); C40(0.87); C109(0.91); C174(0.94)  LDD1584  [14]
 LDCM0381  CL111 HEK-293T C48(0.98); C40(0.89); C109(1.03); C174(0.89)  LDD1585  [14]
 LDCM0382  CL112 HEK-293T C48(1.04); C40(0.96); C109(1.11); C174(0.91)  LDD1586  [14]
 LDCM0383  CL113 HEK-293T C48(0.92); C40(0.87); C109(1.06); C174(0.98)  LDD1587  [14]
 LDCM0384  CL114 HEK-293T C48(0.92); C40(0.90); C109(0.97); C174(0.87)  LDD1588  [14]
 LDCM0385  CL115 HEK-293T C48(1.03); C40(1.02); C109(0.81); C174(1.03)  LDD1589  [14]
 LDCM0386  CL116 HEK-293T C48(0.95); C40(1.21); C109(1.08); C174(0.96)  LDD1590  [14]
 LDCM0387  CL117 HEK-293T C48(0.99); C40(1.04); C109(1.10); C174(0.88)  LDD1591  [14]
 LDCM0388  CL118 HEK-293T C48(0.93); C40(1.11); C109(0.88); C174(0.95)  LDD1592  [14]
 LDCM0389  CL119 HEK-293T C48(1.02); C40(1.01); C109(0.97); C174(1.01)  LDD1593  [14]
 LDCM0390  CL12 HEK-293T C48(1.10); C40(1.01); C109(0.95); C174(1.11)  LDD1594  [14]
 LDCM0391  CL120 HEK-293T C48(0.98); C40(1.14); C109(1.03); C174(0.99)  LDD1595  [14]
 LDCM0392  CL121 HEK-293T C48(0.95); C40(0.98); C109(1.11); C174(0.94)  LDD1596  [14]
 LDCM0393  CL122 HEK-293T C48(0.91); C40(0.92); C109(0.93); C174(0.96)  LDD1597  [14]
 LDCM0394  CL123 HEK-293T C48(0.90); C40(1.04); C109(0.99); C174(0.90)  LDD1598  [14]
 LDCM0395  CL124 HEK-293T C48(0.93); C40(1.00); C109(0.90); C174(0.98)  LDD1599  [14]
 LDCM0396  CL125 HEK-293T C48(0.92); C40(0.90); C109(1.13); C174(0.97)  LDD1600  [14]
 LDCM0397  CL126 HEK-293T C48(0.96); C40(1.11); C109(0.92); C174(0.87)  LDD1601  [14]
 LDCM0398  CL127 HEK-293T C48(1.08); C40(1.09); C109(1.03); C174(0.94)  LDD1602  [14]
 LDCM0399  CL128 HEK-293T C48(1.01); C40(1.04); C109(0.97); C174(0.84)  LDD1603  [14]
 LDCM0400  CL13 HEK-293T C48(0.98); C40(1.03); C109(1.00); C174(1.04)  LDD1604  [14]
 LDCM0401  CL14 HEK-293T C48(1.00); C40(0.94); C109(0.99); C174(1.07)  LDD1605  [14]
 LDCM0402  CL15 HEK-293T C48(0.95); C40(0.97); C109(0.94); C174(0.94)  LDD1606  [14]
 LDCM0403  CL16 HEK-293T C48(1.02); C40(1.19); C109(0.97); C174(1.12)  LDD1607  [14]
 LDCM0404  CL17 HEK-293T C48(0.95); C40(0.90); C109(0.88); C174(0.94)  LDD1608  [14]
 LDCM0405  CL18 HEK-293T C48(0.97); C40(0.98); C109(0.93); C174(1.06)  LDD1609  [14]
 LDCM0406  CL19 HEK-293T C48(1.15); C40(0.94); C109(0.98); C174(1.14)  LDD1610  [14]
 LDCM0407  CL2 HEK-293T C48(0.99); C40(0.97); C109(0.96); C174(1.03)  LDD1611  [14]
 LDCM0408  CL20 HEK-293T C48(1.19); C40(1.26); C109(0.96); C174(1.06)  LDD1612  [14]
 LDCM0409  CL21 HEK-293T C48(1.09); C40(1.12); C109(0.89); C174(0.90)  LDD1613  [14]
 LDCM0410  CL22 HEK-293T C48(1.31); C40(1.34); C109(1.02); C174(1.09)  LDD1614  [14]
 LDCM0411  CL23 HEK-293T C48(1.02); C40(1.22); C109(1.08); C174(1.06)  LDD1615  [14]
 LDCM0412  CL24 HEK-293T C48(1.10); C40(1.16); C109(0.97); C174(1.18)  LDD1616  [14]
 LDCM0413  CL25 HEK-293T C48(0.95); C40(0.90); C109(1.01); C174(0.96)  LDD1617  [14]
 LDCM0414  CL26 HEK-293T C48(1.07); C40(0.86); C109(0.97); C174(1.03)  LDD1618  [14]
 LDCM0415  CL27 HEK-293T C48(1.12); C40(0.94); C109(1.26); C174(0.99)  LDD1619  [14]
 LDCM0416  CL28 HEK-293T C48(1.05); C40(1.02); C109(1.07); C174(1.09)  LDD1620  [14]
 LDCM0417  CL29 HEK-293T C48(1.07); C40(1.05); C109(1.06); C174(1.00)  LDD1621  [14]
 LDCM0418  CL3 HEK-293T C48(1.10); C40(1.12); C109(0.99); C174(1.00)  LDD1622  [14]
 LDCM0419  CL30 HEK-293T C48(1.04); C40(1.06); C109(1.00); C174(1.08)  LDD1623  [14]
 LDCM0420  CL31 HEK-293T C48(1.19); C40(0.83); C109(0.93); C174(1.07)  LDD1624  [14]
 LDCM0421  CL32 HEK-293T C48(1.17); C40(1.11); C109(0.89); C174(1.16)  LDD1625  [14]
 LDCM0422  CL33 HEK-293T C48(1.00); C40(0.89); C109(0.88); C174(0.87)  LDD1626  [14]
 LDCM0423  CL34 HEK-293T C48(1.29); C40(1.08); C109(0.90); C174(1.10)  LDD1627  [14]
 LDCM0424  CL35 HEK-293T C48(0.97); C40(1.20); C109(1.01); C174(1.19)  LDD1628  [14]
 LDCM0425  CL36 HEK-293T C48(1.09); C40(1.18); C109(0.93); C174(1.15)  LDD1629  [14]
 LDCM0426  CL37 HEK-293T C48(0.96); C40(1.00); C109(1.09); C174(1.03)  LDD1630  [14]
 LDCM0428  CL39 HEK-293T C48(0.96); C40(0.91); C109(0.82); C174(0.96)  LDD1632  [14]
 LDCM0429  CL4 HEK-293T C48(1.05); C40(1.25); C109(0.96); C174(1.07)  LDD1633  [14]
 LDCM0430  CL40 HEK-293T C48(1.04); C40(0.94); C109(1.25); C174(1.14)  LDD1634  [14]
 LDCM0431  CL41 HEK-293T C48(1.05); C40(0.93); C109(1.00); C174(0.97)  LDD1635  [14]
 LDCM0432  CL42 HEK-293T C48(1.07); C40(0.98); C109(1.01); C174(1.03)  LDD1636  [14]
 LDCM0433  CL43 HEK-293T C48(1.08); C40(0.77); C109(0.83); C174(1.10)  LDD1637  [14]
 LDCM0434  CL44 HEK-293T C48(1.19); C40(1.09); C109(0.91); C174(1.10)  LDD1638  [14]
 LDCM0435  CL45 HEK-293T C48(1.10); C40(0.94); C109(1.05); C174(0.97)  LDD1639  [14]
 LDCM0436  CL46 HEK-293T C48(1.21); C40(1.18); C109(1.01); C174(1.20)  LDD1640  [14]
 LDCM0437  CL47 HEK-293T C48(1.01); C40(1.13); C109(1.06); C174(1.20)  LDD1641  [14]
 LDCM0438  CL48 HEK-293T C48(1.13); C40(1.02); C109(0.95); C174(1.10)  LDD1642  [14]
 LDCM0439  CL49 HEK-293T C48(0.95); C40(0.85); C109(0.98); C174(0.96)  LDD1643  [14]
 LDCM0440  CL5 HEK-293T C48(0.97); C40(0.96); C109(1.04); C174(1.03)  LDD1644  [14]
 LDCM0441  CL50 HEK-293T C48(0.98); C40(0.95); C109(0.88); C174(0.97)  LDD1645  [14]
 LDCM0443  CL52 HEK-293T C48(0.96); C40(0.97); C109(0.98); C174(1.11)  LDD1646  [14]
 LDCM0444  CL53 HEK-293T C48(0.99); C40(0.99); C109(0.94); C174(0.90)  LDD1647  [14]
 LDCM0445  CL54 HEK-293T C48(0.89); C40(0.98); C109(0.93); C174(0.88)  LDD1648  [14]
 LDCM0446  CL55 HEK-293T C48(1.11); C40(0.71); C109(0.94); C174(1.05)  LDD1649  [14]
 LDCM0447  CL56 HEK-293T C48(1.11); C40(0.98); C109(1.03); C174(1.02)  LDD1650  [14]
 LDCM0448  CL57 HEK-293T C48(1.03); C40(0.93); C109(0.93); C174(0.89)  LDD1651  [14]
 LDCM0449  CL58 HEK-293T C48(1.21); C40(1.10); C109(0.88); C174(1.05)  LDD1652  [14]
 LDCM0450  CL59 HEK-293T C48(0.99); C40(1.08); C109(1.00); C174(1.12)  LDD1653  [14]
 LDCM0451  CL6 HEK-293T C48(0.97); C40(1.01); C109(0.84); C174(0.90)  LDD1654  [14]
 LDCM0452  CL60 HEK-293T C48(1.02); C40(1.09); C109(1.05); C174(1.00)  LDD1655  [14]
 LDCM0453  CL61 HEK-293T C48(0.99); C40(0.92); C109(1.00); C174(0.91)  LDD1656  [14]
 LDCM0454  CL62 HEK-293T C48(1.01); C40(1.02); C109(1.19); C174(0.97)  LDD1657  [14]
 LDCM0455  CL63 HEK-293T C48(1.01); C40(0.94); C109(1.07); C174(0.96)  LDD1658  [14]
 LDCM0456  CL64 HEK-293T C48(0.97); C40(0.97); C109(0.79); C174(0.98)  LDD1659  [14]
 LDCM0457  CL65 HEK-293T C48(1.05); C40(0.99); C109(1.05); C174(1.00)  LDD1660  [14]
 LDCM0458  CL66 HEK-293T C48(1.09); C40(1.05); C109(0.96); C174(0.97)  LDD1661  [14]
 LDCM0459  CL67 HEK-293T C48(1.06); C40(0.63); C109(1.02); C174(1.07)  LDD1662  [14]
 LDCM0460  CL68 HEK-293T C48(1.07); C40(1.01); C109(0.98); C174(1.00)  LDD1663  [14]
 LDCM0461  CL69 HEK-293T C48(1.07); C40(1.05); C109(1.05); C174(0.96)  LDD1664  [14]
 LDCM0462  CL7 HEK-293T C48(1.05); C40(0.78); C109(0.97); C174(1.07)  LDD1665  [14]
 LDCM0463  CL70 HEK-293T C48(1.24); C40(1.13); C109(0.98); C174(1.06)  LDD1666  [14]
 LDCM0464  CL71 HEK-293T C48(1.04); C40(1.17); C109(0.95); C174(1.08)  LDD1667  [14]
 LDCM0465  CL72 HEK-293T C48(1.09); C40(1.31); C109(0.97); C174(1.03)  LDD1668  [14]
 LDCM0466  CL73 HEK-293T C48(0.94); C40(0.89); C109(1.03); C174(0.90)  LDD1669  [14]
 LDCM0467  CL74 HEK-293T C48(1.03); C40(1.00); C109(1.12); C174(0.98)  LDD1670  [14]
 LDCM0469  CL76 HEK-293T C48(1.00); C40(1.12); C109(1.06); C174(1.07)  LDD1672  [14]
 LDCM0470  CL77 HEK-293T C48(0.90); C40(0.87); C109(0.90); C174(0.89)  LDD1673  [14]
 LDCM0471  CL78 HEK-293T C48(1.05); C40(0.99); C109(0.99); C174(1.00)  LDD1674  [14]
 LDCM0472  CL79 HEK-293T C48(1.05); C40(0.86); C109(0.81); C174(1.07)  LDD1675  [14]
 LDCM0473  CL8 HEK-293T C48(0.85); C40(0.84); C109(0.87); C174(0.71)  LDD1676  [14]
 LDCM0474  CL80 HEK-293T C48(1.11); C40(1.19); C109(0.99); C174(1.02)  LDD1677  [14]
 LDCM0475  CL81 HEK-293T C48(1.09); C40(1.02); C109(1.00); C174(1.01)  LDD1678  [14]
 LDCM0476  CL82 HEK-293T C48(1.17); C40(1.11); C109(1.01); C174(1.10)  LDD1679  [14]
 LDCM0477  CL83 HEK-293T C48(1.00); C40(1.07); C109(0.95); C174(1.04)  LDD1680  [14]
 LDCM0478  CL84 HEK-293T C48(1.03); C40(0.99); C109(0.89); C174(1.05)  LDD1681  [14]
 LDCM0479  CL85 HEK-293T C48(0.95); C40(0.98); C109(1.02); C174(0.93)  LDD1682  [14]
 LDCM0480  CL86 HEK-293T C48(1.01); C40(1.05); C109(0.90); C174(0.83)  LDD1683  [14]
 LDCM0481  CL87 HEK-293T C48(1.09); C40(0.93); C109(1.10); C174(0.84)  LDD1684  [14]
 LDCM0482  CL88 HEK-293T C48(0.99); C40(0.96); C109(1.02); C174(0.84)  LDD1685  [14]
 LDCM0483  CL89 HEK-293T C48(0.95); C40(1.08); C109(0.96); C174(0.92)  LDD1686  [14]
 LDCM0484  CL9 HEK-293T C48(1.14); C40(0.90); C109(0.96); C174(0.95)  LDD1687  [14]
 LDCM0485  CL90 HEK-293T C48(0.88); C40(0.92); C109(0.82); C174(0.76)  LDD1688  [14]
 LDCM0486  CL91 HEK-293T C48(1.08); C40(1.02); C109(0.92); C174(0.95)  LDD1689  [14]
 LDCM0487  CL92 HEK-293T C48(1.00); C40(1.02); C109(1.01); C174(0.93)  LDD1690  [14]
 LDCM0488  CL93 HEK-293T C48(1.03); C40(0.93); C109(0.86); C174(0.93)  LDD1691  [14]
 LDCM0489  CL94 HEK-293T C48(1.14); C40(1.17); C109(1.05); C174(1.03)  LDD1692  [14]
 LDCM0490  CL95 HEK-293T C48(0.92); C40(0.97); C109(0.95); C174(0.86)  LDD1693  [14]
 LDCM0491  CL96 HEK-293T C48(0.98); C40(1.06); C109(0.88); C174(0.94)  LDD1694  [14]
 LDCM0492  CL97 HEK-293T C48(0.96); C40(0.73); C109(1.11); C174(0.92)  LDD1695  [14]
 LDCM0493  CL98 HEK-293T C48(0.97); C40(1.01); C109(0.93); C174(0.96)  LDD1696  [14]
 LDCM0494  CL99 HEK-293T C48(0.96); C40(0.93); C109(1.17); C174(0.89)  LDD1697  [14]
 LDCM0634  CY-0357 Hep-G2 C174(0.93)  LDD2228  [8]
 LDCM0028  Dobutamine HEK-293T 7.32  LDD0180  [4]
 LDCM0495  E2913 HEK-293T C48(1.02); C40(0.85); C109(1.13); C174(0.91)  LDD1698  [14]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C127(0.93)  LDD1702  [16]
 LDCM0031  Epigallocatechin gallate HEK-293T 21.27  LDD0183  [4]
 LDCM0625  F8 Ramos C48(1.87)  LDD2187  [17]
 LDCM0573  Fragment11 Ramos C48(0.35)  LDD2190  [17]
 LDCM0576  Fragment14 Ramos C48(0.65)  LDD2193  [17]
 LDCM0586  Fragment28 Ramos C48(0.72)  LDD2198  [17]
 LDCM0468  Fragment33 HEK-293T C48(1.07); C40(1.07); C109(1.19); C174(0.91)  LDD1671  [14]
 LDCM0566  Fragment4 Ramos C48(0.82)  LDD2184  [17]
 LDCM0427  Fragment51 HEK-293T C48(1.03); C40(1.00); C109(1.03); C174(0.97)  LDD1631  [14]
 LDCM0569  Fragment7 Ramos C48(0.85)  LDD2186  [17]
 LDCM0022  KB02 HEK-293T C174(0.89); C48(1.00); C40(0.99); C109(0.99)  LDD1492  [14]
 LDCM0023  KB03 HEK-293T C174(0.96); C48(0.98); C40(1.03); C109(1.02)  LDD1497  [14]
 LDCM0024  KB05 SKMEL24 C32(1.22)  LDD3323  [3]
 LDCM0030  Luteolin HEK-293T 23.04  LDD0182  [4]
 LDCM0029  Quercetin HEK-293T 28.33  LDD0181  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transitional endoplasmic reticulum ATPase (VCP) AAA ATPase family P55072
Dual specificity protein kinase CLK2 (CLK2) CMGC Ser/Thr protein kinase family P49760
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcription factor 4 (TCF4) . P15884
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein INCA1 (INCA1) INCA family Q0VD86
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin-associated protein 1-1 (KRTAP1-1) KRTAP type 1 family Q07627
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Notch homolog 2 N-terminal-like protein A (NOTCH2NLA) NOTCH family Q7Z3S9
Transforming acidic coiled-coil-containing protein 3 (TACC3) TACC family Q9Y6A5

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
12 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
16 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
17 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578