Details of the Target

General Information of Target

Target ID LDTP07605
Target Name La-related protein 1 (LARP1)
Gene Name LARP1
Gene ID 23367
Synonyms
KIAA0731; LARP; La-related protein 1; La ribonucleoprotein domain family member 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATQVEPLLPGGATLLQAEEHGGLVRKKPPPAPEGKGEPGPNDVRGGEPDGSARRPRPPC
AKPHKEGTGQQERESPRPLQLPGAEGPAISDGEEGGGEPGAGGGAAGAAGAGRRDFVEAP
PPKVNPWTKNALPPVLTTVNGQSPPEHSAPAKVVRAAVPKQRKGSKVGDFGDAINWPTPG
EIAHKSVQPQSHKPQPTRKLPPKKDMKEQEKGEGSDSKESPKTKSDESGEEKNGDEDCQR
GGQKKKGNKHKWVPLQIDMKPEVPREKLASRPTRPPEPRHIPANRGEIKGSESATYVPVA
PPTPAWQPEIKPEPAWHDQDETSSVKSDGAGGARASFRGRGRGRGRGRGRGRGGTRTHFD
YQFGYRKFDGVEGPRTPKYMNNITYYFDNVSSTELYSVDQELLKDYIKRQIEYYFSVDNL
ERDFFLRRKMDADGFLPITLIASFHRVQALTTDISLIFAALKDSKVVEIVDEKVRRREEP
EKWPLPPIVDYSQTDFSQLLNCPEFVPRQHYQKETESAPGSPRAVTPVPTKTEEVSNLKT
LPKGLSASLPDLDSENWIEVKKRPRPSPARPKKSEESRFSHLTSLPQQLPSQQLMSKDQD
EQEELDFLFDEEMEQMDGRKNTFTAWSDEESDYEIDDRDVNKILIVTQTPHYMRRHPGGD
RTGNHTSRAKMSAELAKVINDGLFYYEQDLWAEKFEPEYSQIKQEVENFKKVNMISREQF
DTLTPEPPVDPNQEVPPGPPRFQQVPTDALANKLFGAPEPSTIARSLPTTVPESPNYRNT
RTPRTPRTPQLKDSSQTSRFYPVVKEGRTLDAKMPRKRKTRHSSNPPLESHVGWVMDSRE
HRPRTASISSSPSEGTPTVGSYGCTPQSLPKFQHPSHELLKENGFTQHVYHKYRRRCLNE
RKRLGIGQSQEMNTLFRFWSFFLRDHFNKKMYEEFKQLALEDAKEGYRYGLECLFRYYSY
GLEKKFRLDIFKDFQEETVKDYEAGQLYGLEKFWAFLKYSKAKNLDIDPKLQEYLGKFRR
LEDFRVDPPMGEEGNHKRHSVVAGGGGGEGRKRCPSQSSSRPAAMISQPPTPPTGQPVRE
DAKWTSQHSNTQTLGK
Target Bioclass
Other
Family
LARP family
Subcellular location
Cytoplasm
Function
RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability. Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery . The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1. When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA. Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif. Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes. Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis. Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation. Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis.; (Microbial infection) Positively regulates the replication of dengue virus (DENV).
TTD ID
T01727
Uniprot ID
Q6PKG0
DrugMap ID
TTSN1YP
Ensemble ID
ENST00000336314.9
HGNC ID
HGNC:29531

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 Deletion: p.T303PfsTer23 DBIA    Probe Info 
FADU SNV: p.V135A .
HCT116 Deletion: p.P145QfsTer10; p.T303PfsTer23 DBIA    Probe Info 
HCT15 SNV: p.H445Q; p.D981E DBIA    Probe Info 
HT115 SNV: p.R956Q DBIA    Probe Info 
IM95 Deletion: p.T303PfsTer23 DBIA    Probe Info 
JURKAT Deletion: p.D660TfsTer12 Compound 10    Probe Info 
KYSE410 SNV: p.G242R DBIA    Probe Info 
LS180 SNV: p.W252C DBIA    Probe Info 
MOLT4 Deletion: p.T303PfsTer23 IA-alkyne    Probe Info 
NCIH2286 SNV: p.D610Y DBIA    Probe Info 
RKO SNV: p.G682D DBIA    Probe Info 
RL952 SNV: p.T780I DBIA    Probe Info 
SKNSH SNV: p.G103Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 37 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
DAyne
 Probe Info  		2.12  LDD0261  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
ONAyne
 Probe Info  		K792(5.26)  LDD0274  [4]
STPyne
 Probe Info  		K1017(7.05); K160(5.88); K513(0.55); K531(10.00)  LDD0277  [4]
Probe 1
 Probe Info  		Y777(5.19)  LDD3495  [5]
BTD
 Probe Info  		C897(1.50)  LDD1700  [6]
Sulforaphane-probe2
 Probe Info  		2.06  LDD0042  [7]
DA-P3
 Probe Info  		5.30  LDD0181  [8]
AHL-Pu-1
 Probe Info  		C238(3.79)  LDD0168  [9]
EA-probe
 Probe Info  		N.A.  LDD0440  [10]
DBIA
 Probe Info  		C864(1.08); C238(1.04)  LDD0078  [11]
5E-2FA
 Probe Info  		H21(0.00); H192(0.00)  LDD2235  [12]
ATP probe
 Probe Info  		K1003(0.00); K367(0.00); K65(0.00); K260(0.00)  LDD0199  [13]
4-Iodoacetamidophenylacetylene
 Probe Info  		C1054(0.00); C502(0.00); C238(0.00); C864(0.00)  LDD0038  [14]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [15]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [16]
Lodoacetamide azide
 Probe Info  		C1054(0.00); C502(0.00); C864(0.00); C953(0.00)  LDD0037  [14]
IPM
 Probe Info  		C1054(0.00); C864(0.00)  LDD0025  [17]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [17]
NAIA_4
 Probe Info  		C502(0.00); C864(0.00)  LDD2226  [18]
TFBX
 Probe Info  		C1054(0.00); C864(0.00)  LDD0027  [17]
WYneN
 Probe Info  		N.A.  LDD0021  [19]
Compound 10
 Probe Info  		C1054(0.00); C238(0.00); C864(0.00)  LDD2216  [20]
PF-06672131
 Probe Info  		N.A.  LDD0017  [21]
PPMS
 Probe Info  		N.A.  LDD0008  [19]
SF
 Probe Info  		Y361(0.00); Y777(0.00); Y960(0.00); Y365(0.00)  LDD0028  [22]
VSF
 Probe Info  		N.A.  LDD0007  [19]
Phosphinate-6
 Probe Info  		C238(0.00); C60(0.00); C864(0.00)  LDD0018  [23]
Ox-W18
 Probe Info  		N.A.  LDD2175  [24]
1c-yne
 Probe Info  		K753(0.00); K429(0.00); K694(0.00)  LDD0228  [25]
Acrolein
 Probe Info  		H1039(0.00); C238(0.00)  LDD0217  [26]
Methacrolein
 Probe Info  		N.A.  LDD0218  [26]
W1
 Probe Info  		N.A.  LDD0236  [27]
AOyne
 Probe Info  		6.90  LDD0443  [28]
NAIA_5
 Probe Info  		C1054(0.00); C502(0.00); C953(0.00); C897(0.00)  LDD2223  [18]
HHS-482
 Probe Info  		Y365(0.99)  LDD2239  [29]
PAL-AfBPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C191
 Probe Info  		9.58  LDD1868  [30]
FFF probe11
 Probe Info  		11.30  LDD0471  [31]
FFF probe13
 Probe Info  		14.73  LDD0475  [31]
FFF probe2
 Probe Info  		6.62  LDD0463  [31]
FFF probe3
 Probe Info  		18.47  LDD0464  [31]
FFF probe9
 Probe Info  		20.00  LDD0470  [31]
Staurosporine capture compound
 Probe Info  		N.A.  LDD0083  [32]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C1054(0.76)  LDD2142  [6]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C1054(0.96)  LDD2112  [6]
 LDCM0025  4SU-RNA HEK-293T C238(3.79)  LDD0168  [9]
 LDCM0026  4SU-RNA+native RNA HEK-293T C238(3.13)  LDD0169  [9]
 LDCM0214  AC1 HCT 116 C238(0.85); C864(1.20); C953(1.18)  LDD0531  [11]
 LDCM0215  AC10 HCT 116 C238(1.68); C864(1.21); C953(0.66)  LDD0532  [11]
 LDCM0216  AC100 HCT 116 C238(0.96); C864(0.84)  LDD0533  [11]
 LDCM0217  AC101 HCT 116 C238(1.08); C864(0.86)  LDD0534  [11]
 LDCM0218  AC102 HCT 116 C238(0.85); C864(0.95)  LDD0535  [11]
 LDCM0219  AC103 HCT 116 C238(1.45); C864(1.22)  LDD0536  [11]
 LDCM0220  AC104 HCT 116 C238(0.91); C864(1.03)  LDD0537  [11]
 LDCM0221  AC105 HCT 116 C238(1.45); C864(1.03)  LDD0538  [11]
 LDCM0222  AC106 HCT 116 C238(1.56); C864(1.00)  LDD0539  [11]
 LDCM0223  AC107 HCT 116 C238(1.38); C864(1.25)  LDD0540  [11]
 LDCM0224  AC108 HCT 116 C238(1.23); C864(0.91)  LDD0541  [11]
 LDCM0225  AC109 HCT 116 C238(0.81); C864(0.92)  LDD0542  [11]
 LDCM0226  AC11 HCT 116 C238(1.30); C864(1.34); C953(0.63)  LDD0543  [11]
 LDCM0227  AC110 HCT 116 C238(1.06); C864(0.97)  LDD0544  [11]
 LDCM0228  AC111 HCT 116 C238(1.12); C864(0.92)  LDD0545  [11]
 LDCM0229  AC112 HCT 116 C238(0.94); C864(1.12)  LDD0546  [11]
 LDCM0230  AC113 HCT 116 C238(1.08); C864(1.00)  LDD0547  [11]
 LDCM0231  AC114 HCT 116 C238(1.47); C864(1.15)  LDD0548  [11]
 LDCM0232  AC115 HCT 116 C238(1.74); C864(1.33)  LDD0549  [11]
 LDCM0233  AC116 HCT 116 C238(1.73); C864(1.42)  LDD0550  [11]
 LDCM0234  AC117 HCT 116 C238(1.42); C864(1.15)  LDD0551  [11]
 LDCM0235  AC118 HCT 116 C238(1.38); C864(1.13)  LDD0552  [11]
 LDCM0236  AC119 HCT 116 C238(1.29); C864(1.18)  LDD0553  [11]
 LDCM0237  AC12 HCT 116 C238(0.99); C864(1.07); C953(0.78)  LDD0554  [11]
 LDCM0238  AC120 HCT 116 C238(0.83); C864(1.33)  LDD0555  [11]
 LDCM0239  AC121 HCT 116 C238(1.53); C864(1.03)  LDD0556  [11]
 LDCM0240  AC122 HCT 116 C238(1.20); C864(1.10)  LDD0557  [11]
 LDCM0241  AC123 HCT 116 C238(1.35); C864(0.99)  LDD0558  [11]
 LDCM0242  AC124 HCT 116 C238(1.07); C864(0.97)  LDD0559  [11]
 LDCM0243  AC125 HCT 116 C238(1.28); C864(1.01)  LDD0560  [11]
 LDCM0244  AC126 HCT 116 C238(1.79); C864(1.18)  LDD0561  [11]
 LDCM0245  AC127 HCT 116 C238(1.95); C864(1.35)  LDD0562  [11]
 LDCM0246  AC128 HCT 116 C238(1.52); C864(1.22); C953(0.82)  LDD0563  [11]
 LDCM0247  AC129 HCT 116 C238(1.36); C864(0.94); C953(1.12)  LDD0564  [11]
 LDCM0249  AC130 HCT 116 C238(2.09); C864(1.18); C953(0.87)  LDD0566  [11]
 LDCM0250  AC131 HCT 116 C238(1.76); C864(0.96); C953(0.88)  LDD0567  [11]
 LDCM0251  AC132 HCT 116 C238(1.45); C864(0.90); C953(1.04)  LDD0568  [11]
 LDCM0252  AC133 HCT 116 C238(1.64); C864(0.98); C953(0.87)  LDD0569  [11]
 LDCM0253  AC134 HCT 116 C238(2.00); C864(1.32); C953(0.81)  LDD0570  [11]
 LDCM0254  AC135 HCT 116 C238(1.86); C864(1.03); C953(0.83)  LDD0571  [11]
 LDCM0255  AC136 HCT 116 C238(1.05); C864(1.18); C953(0.95)  LDD0572  [11]
 LDCM0256  AC137 HCT 116 C238(1.02); C864(1.03); C953(0.96)  LDD0573  [11]
 LDCM0257  AC138 HCT 116 C238(1.58); C864(1.17); C953(0.80)  LDD0574  [11]
 LDCM0258  AC139 HCT 116 C238(1.54); C864(1.08); C953(0.86)  LDD0575  [11]
 LDCM0259  AC14 HCT 116 C238(1.69); C864(1.09); C953(0.72)  LDD0576  [11]
 LDCM0260  AC140 HCT 116 C238(2.24); C864(1.23); C953(0.83)  LDD0577  [11]
 LDCM0261  AC141 HCT 116 C238(1.58); C864(1.17); C953(0.81)  LDD0578  [11]
 LDCM0262  AC142 HCT 116 C238(1.28); C864(0.91); C953(1.15)  LDD0579  [11]
 LDCM0263  AC143 HCT 116 C953(0.95); C864(1.06); C238(1.17)  LDD0580  [11]
 LDCM0264  AC144 HCT 116 C953(0.68); C864(1.31); C238(1.39)  LDD0581  [11]
 LDCM0265  AC145 HCT 116 C953(0.83); C864(1.11); C238(1.13)  LDD0582  [11]
 LDCM0266  AC146 HCT 116 C953(0.55); C864(1.39); C238(1.63)  LDD0583  [11]
 LDCM0267  AC147 HCT 116 C953(0.55); C864(1.37); C238(1.40)  LDD0584  [11]
 LDCM0268  AC148 HCT 116 C953(0.42); C238(2.04); C864(2.05)  LDD0585  [11]
 LDCM0269  AC149 HCT 116 C953(0.50); C864(1.56); C238(1.76)  LDD0586  [11]
 LDCM0270  AC15 HCT 116 C953(0.60); C864(1.21); C238(1.67)  LDD0587  [11]
 LDCM0271  AC150 HCT 116 C864(1.13); C238(1.15); C953(1.18)  LDD0588  [11]
 LDCM0272  AC151 HCT 116 C953(0.79); C238(1.21); C864(1.25)  LDD0589  [11]
 LDCM0273  AC152 HCT 116 C953(0.51); C238(1.06); C864(1.36)  LDD0590  [11]
 LDCM0274  AC153 HCT 116 C953(0.44); C864(2.23); C238(2.42)  LDD0591  [11]
 LDCM0621  AC154 HCT 116 C238(1.68); C864(1.39); C953(0.84)  LDD2158  [11]
 LDCM0622  AC155 HCT 116 C238(1.55); C864(1.42); C953(0.61)  LDD2159  [11]
 LDCM0623  AC156 HCT 116 C238(1.24); C864(1.08); C953(0.81)  LDD2160  [11]
 LDCM0624  AC157 HCT 116 C238(1.31); C864(1.22); C953(0.99)  LDD2161  [11]
 LDCM0276  AC17 HCT 116 C238(0.95); C864(1.14)  LDD0593  [11]
 LDCM0277  AC18 HCT 116 C238(0.64); C864(1.58)  LDD0594  [11]
 LDCM0278  AC19 HCT 116 C864(1.18); C238(1.20)  LDD0595  [11]
 LDCM0279  AC2 HCT 116 C238(0.98); C953(1.13); C864(1.18)  LDD0596  [11]
 LDCM0280  AC20 HCT 116 C238(1.08); C864(1.22)  LDD0597  [11]
 LDCM0281  AC21 HCT 116 C238(0.97); C864(1.21)  LDD0598  [11]
 LDCM0282  AC22 HCT 116 C238(1.00); C864(1.08)  LDD0599  [11]
 LDCM0283  AC23 HCT 116 C238(0.93); C864(1.17)  LDD0600  [11]
 LDCM0284  AC24 HCT 116 C864(1.01); C238(1.31)  LDD0601  [11]
 LDCM0285  AC25 HCT 116 C864(1.02); C238(2.03)  LDD0602  [11]
 LDCM0286  AC26 HCT 116 C864(1.22); C238(2.23)  LDD0603  [11]
 LDCM0287  AC27 HCT 116 C864(1.27); C238(2.09)  LDD0604  [11]
 LDCM0288  AC28 HCT 116 C864(1.25); C238(1.69)  LDD0605  [11]
 LDCM0289  AC29 HCT 116 C864(1.24); C238(2.62)  LDD0606  [11]
 LDCM0290  AC3 HCT 116 C238(0.88); C953(1.06); C864(1.15)  LDD0607  [11]
 LDCM0291  AC30 HCT 116 C864(1.42); C238(1.60)  LDD0608  [11]
 LDCM0292  AC31 HCT 116 C864(1.15); C238(2.40)  LDD0609  [11]
 LDCM0293  AC32 HCT 116 C864(1.50); C238(2.39)  LDD0610  [11]
 LDCM0294  AC33 HCT 116 C864(1.34); C238(2.75)  LDD0611  [11]
 LDCM0295  AC34 HCT 116 C864(1.71); C238(2.34)  LDD0612  [11]
 LDCM0296  AC35 HCT 116 C238(0.95); C864(0.96); C953(1.43)  LDD0613  [11]
 LDCM0297  AC36 HCT 116 C864(0.96); C953(1.16); C238(1.17)  LDD0614  [11]
 LDCM0298  AC37 HCT 116 C864(0.97); C953(1.03); C238(1.22)  LDD0615  [11]
 LDCM0299  AC38 HCT 116 C864(1.04); C238(1.08); C953(1.29)  LDD0616  [11]
 LDCM0300  AC39 HCT 116 C238(1.04); C953(1.07); C864(1.15)  LDD0617  [11]
 LDCM0301  AC4 HCT 116 C953(0.91); C238(1.00); C864(1.33)  LDD0618  [11]
 LDCM0302  AC40 HCT 116 C953(0.88); C238(1.21); C864(1.29)  LDD0619  [11]
 LDCM0303  AC41 HCT 116 C953(1.00); C864(1.10); C238(1.33)  LDD0620  [11]
 LDCM0304  AC42 HCT 116 C953(1.03); C864(1.13); C238(1.18)  LDD0621  [11]
 LDCM0305  AC43 HCT 116 C864(1.23); C953(1.25); C238(1.30)  LDD0622  [11]
 LDCM0306  AC44 HCT 116 C953(1.02); C864(1.19); C238(1.24)  LDD0623  [11]
 LDCM0307  AC45 HCT 116 C953(0.83); C864(1.28); C238(1.44)  LDD0624  [11]
 LDCM0308  AC46 HCT 116 C864(1.04); C953(1.06); C238(1.24)  LDD0625  [11]
 LDCM0309  AC47 HCT 116 C953(0.96); C864(0.99); C238(1.38)  LDD0626  [11]
 LDCM0310  AC48 HCT 116 C864(1.00); C953(1.09); C238(1.29)  LDD0627  [11]
 LDCM0311  AC49 HCT 116 C953(0.69); C238(1.50); C864(1.58)  LDD0628  [11]
 LDCM0312  AC5 HCT 116 C238(0.85); C953(0.89); C864(1.32)  LDD0629  [11]
 LDCM0313  AC50 HCT 116 C953(0.68); C864(1.37); C238(1.93)  LDD0630  [11]
 LDCM0314  AC51 HCT 116 C864(0.90); C238(1.10); C953(1.17)  LDD0631  [11]
 LDCM0315  AC52 HCT 116 C953(0.85); C864(1.03); C238(1.37)  LDD0632  [11]
 LDCM0316  AC53 HCT 116 C953(0.86); C864(1.23); C238(1.46)  LDD0633  [11]
 LDCM0317  AC54 HCT 116 C953(0.84); C238(1.19); C864(1.25)  LDD0634  [11]
 LDCM0318  AC55 HCT 116 C953(0.84); C864(1.47); C238(1.91)  LDD0635  [11]
 LDCM0319  AC56 HCT 116 C953(0.60); C864(2.28); C238(2.93)  LDD0636  [11]
 LDCM0320  AC57 HCT 116 C953(0.69); C864(1.32); C238(1.71)  LDD0637  [11]
 LDCM0321  AC58 HCT 116 C953(0.58); C864(1.53); C238(1.77)  LDD0638  [11]
 LDCM0322  AC59 HCT 116 C953(0.59); C864(1.39); C238(1.56)  LDD0639  [11]
 LDCM0323  AC6 HCT 116 C953(0.62); C864(1.35); C238(1.50)  LDD0640  [11]
 LDCM0324  AC60 HCT 116 C953(0.70); C864(1.51); C238(1.86)  LDD0641  [11]
 LDCM0325  AC61 HCT 116 C953(0.78); C864(1.27); C238(1.93)  LDD0642  [11]
 LDCM0326  AC62 HCT 116 C953(0.54); C864(1.38); C238(2.03)  LDD0643  [11]
 LDCM0327  AC63 HCT 116 C953(0.74); C238(1.39); C864(1.41)  LDD0644  [11]
 LDCM0328  AC64 HCT 116 C953(0.60); C864(1.48); C238(1.73)  LDD0645  [11]
 LDCM0329  AC65 HCT 116 C953(0.77); C864(1.30); C238(1.32)  LDD0646  [11]
 LDCM0330  AC66 HCT 116 C953(0.82); C238(1.11); C864(1.33)  LDD0647  [11]
 LDCM0331  AC67 HCT 116 C953(0.45); C238(1.26); C864(1.75)  LDD0648  [11]
 LDCM0332  AC68 HCT 116 C953(1.03); C864(1.19); C238(1.24)  LDD0649  [11]
 LDCM0333  AC69 HCT 116 C953(0.93); C864(1.22); C238(1.64)  LDD0650  [11]
 LDCM0334  AC7 HCT 116 C953(0.76); C238(0.94); C864(1.02)  LDD0651  [11]
 LDCM0335  AC70 HCT 116 C953(0.67); C864(1.22); C238(1.42)  LDD0652  [11]
 LDCM0336  AC71 HCT 116 C953(1.11); C864(1.14); C238(1.23)  LDD0653  [11]
 LDCM0337  AC72 HCT 116 C953(0.93); C864(1.16); C238(1.93)  LDD0654  [11]
 LDCM0338  AC73 HCT 116 C953(0.57); C864(1.74); C238(2.40)  LDD0655  [11]
 LDCM0339  AC74 HCT 116 C953(0.59); C864(1.57); C238(1.66)  LDD0656  [11]
 LDCM0340  AC75 HCT 116 C953(0.51); C864(2.11); C238(2.85)  LDD0657  [11]
 LDCM0341  AC76 HCT 116 C953(0.83); C864(1.27); C238(1.63)  LDD0658  [11]
 LDCM0342  AC77 HCT 116 C953(0.76); C864(1.39); C238(2.10)  LDD0659  [11]
 LDCM0343  AC78 HCT 116 C864(1.12); C953(1.21); C238(1.75)  LDD0660  [11]
 LDCM0344  AC79 HCT 116 C953(1.02); C864(1.26); C238(1.57)  LDD0661  [11]
 LDCM0345  AC8 HCT 116 C953(0.67); C238(0.93); C864(1.33)  LDD0662  [11]
 LDCM0346  AC80 HCT 116 C953(0.84); C864(1.20); C238(1.57)  LDD0663  [11]
 LDCM0347  AC81 HCT 116 C238(0.97); C864(1.16); C953(1.27)  LDD0664  [11]
 LDCM0348  AC82 HCT 116 C953(0.57); C238(1.87); C864(2.03)  LDD0665  [11]
 LDCM0349  AC83 HCT 116 C953(0.30); C238(1.85); C864(1.88)  LDD0666  [11]
 LDCM0350  AC84 HCT 116 C953(0.30); C238(1.12); C864(1.73)  LDD0667  [11]
 LDCM0351  AC85 HCT 116 C953(0.44); C238(0.90); C864(1.43)  LDD0668  [11]
 LDCM0352  AC86 HCT 116 C953(0.40); C238(1.17); C864(1.35)  LDD0669  [11]
 LDCM0353  AC87 HCT 116 C953(0.62); C238(0.88); C864(1.10)  LDD0670  [11]
 LDCM0354  AC88 HCT 116 C953(0.35); C238(1.01); C864(1.31)  LDD0671  [11]
 LDCM0355  AC89 HCT 116 C953(0.33); C864(1.45); C238(1.54)  LDD0672  [11]
 LDCM0357  AC90 HCT 116 C953(0.93); C864(0.96); C238(1.09)  LDD0674  [11]
 LDCM0358  AC91 HCT 116 C953(0.25); C864(1.78); C238(1.82)  LDD0675  [11]
 LDCM0359  AC92 HCT 116 C953(0.30); C864(1.56); C238(1.74)  LDD0676  [11]
 LDCM0360  AC93 HCT 116 C953(0.38); C238(0.94); C864(1.22)  LDD0677  [11]
 LDCM0361  AC94 HCT 116 C953(0.59); C238(0.86); C864(1.33)  LDD0678  [11]
 LDCM0362  AC95 HCT 116 C953(0.43); C864(1.16); C238(1.28)  LDD0679  [11]
 LDCM0363  AC96 HCT 116 C953(0.31); C238(1.41); C864(1.44)  LDD0680  [11]
 LDCM0364  AC97 HCT 116 C953(0.40); C238(1.18); C864(1.56)  LDD0681  [11]
 LDCM0365  AC98 HCT 116 C864(1.57); C238(2.17)  LDD0682  [11]
 LDCM0366  AC99 HCT 116 C238(0.82); C864(0.91)  LDD0683  [11]
 LDCM0248  AKOS034007472 HCT 116 C238(1.37); C864(1.01); C953(0.91)  LDD0565  [11]
 LDCM0356  AKOS034007680 HCT 116 C953(0.69); C864(1.12); C238(1.60)  LDD0673  [11]
 LDCM0275  AKOS034007705 HCT 116 C953(0.41); C864(1.97); C238(2.66)  LDD0592  [11]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0404  [1]
 LDCM0020  ARS-1620 HCC44 C864(1.08); C238(1.04)  LDD0078  [11]
 LDCM0087  Capsaicin HEK-293T 6.66  LDD0185  [8]
 LDCM0630  CCW28-3 231MFP C864(1.71)  LDD2214  [33]
 LDCM0108  Chloroacetamide HeLa H1039(0.00); H192(0.00); C238(0.00); H651(0.00)  LDD0222  [26]
 LDCM0632  CL-Sc Hep-G2 C238(1.24); C238(0.98); C1054(0.65)  LDD2227  [18]
 LDCM0367  CL1 HCT 116 C864(1.00); C238(1.08); C953(1.17)  LDD0684  [11]
 LDCM0368  CL10 HCT 116 C953(0.68); C864(1.26); C238(1.89)  LDD0685  [11]
 LDCM0369  CL100 HCT 116 C953(0.96); C238(1.04); C864(1.27)  LDD0686  [11]
 LDCM0370  CL101 HCT 116 C953(0.55); C864(1.15); C238(1.42)  LDD0687  [11]
 LDCM0371  CL102 HCT 116 C953(0.86); C864(0.94); C238(1.26)  LDD0688  [11]
 LDCM0372  CL103 HCT 116 C953(0.73); C864(0.98); C238(1.15)  LDD0689  [11]
 LDCM0373  CL104 HCT 116 C953(0.78); C864(1.16); C238(1.27)  LDD0690  [11]
 LDCM0374  CL105 HCT 116 C238(1.00); C864(1.51)  LDD0691  [11]
 LDCM0375  CL106 HCT 116 C238(1.12); C864(1.91)  LDD0692  [11]
 LDCM0376  CL107 HCT 116 C238(1.14); C864(1.54)  LDD0693  [11]
 LDCM0377  CL108 HCT 116 C238(0.93); C864(1.82)  LDD0694  [11]
 LDCM0378  CL109 HCT 116 C238(1.23); C864(1.38)  LDD0695  [11]
 LDCM0379  CL11 HCT 116 C953(0.62); C864(1.32); C238(2.17)  LDD0696  [11]
 LDCM0380  CL110 HCT 116 C238(1.38); C864(1.67)  LDD0697  [11]
 LDCM0381  CL111 HCT 116 C238(0.92); C864(1.40)  LDD0698  [11]
 LDCM0382  CL112 HCT 116 C864(1.18); C238(1.69)  LDD0699  [11]
 LDCM0383  CL113 HCT 116 C864(1.45); C238(2.04)  LDD0700  [11]
 LDCM0384  CL114 HCT 116 C864(1.23); C238(2.27)  LDD0701  [11]
 LDCM0385  CL115 HCT 116 C864(1.28); C238(2.10)  LDD0702  [11]
 LDCM0386  CL116 HCT 116 C864(1.19); C238(2.32)  LDD0703  [11]
 LDCM0387  CL117 HCT 116 C953(0.69); C238(1.63); C864(1.91)  LDD0704  [11]
 LDCM0388  CL118 HCT 116 C864(1.11); C953(1.26); C238(1.34)  LDD0705  [11]
 LDCM0389  CL119 HCT 116 C953(0.94); C864(1.24); C238(1.87)  LDD0706  [11]
 LDCM0390  CL12 HCT 116 C953(0.62); C864(1.41); C238(2.86)  LDD0707  [11]
 LDCM0391  CL120 HCT 116 C864(1.12); C953(1.15); C238(1.39)  LDD0708  [11]
 LDCM0392  CL121 HCT 116 C953(0.78); C238(1.02); C864(1.06)  LDD0709  [11]
 LDCM0393  CL122 HCT 116 C953(0.93); C864(1.04); C238(1.27)  LDD0710  [11]
 LDCM0394  CL123 HCT 116 C953(0.73); C238(1.44); C864(1.54)  LDD0711  [11]
 LDCM0395  CL124 HCT 116 C953(0.80); C864(1.47); C238(1.70)  LDD0712  [11]
 LDCM0396  CL125 HCT 116 C953(1.01); C238(1.06); C864(1.14)  LDD0713  [11]
 LDCM0397  CL126 HCT 116 C953(0.65); C238(1.04); C864(1.47)  LDD0714  [11]
 LDCM0398  CL127 HCT 116 C953(0.78); C864(1.05); C238(1.24)  LDD0715  [11]
 LDCM0399  CL128 HCT 116 C953(0.62); C864(1.51); C238(1.97)  LDD0716  [11]
 LDCM0400  CL13 HCT 116 C953(0.69); C864(1.21); C238(1.59)  LDD0717  [11]
 LDCM0401  CL14 HCT 116 C953(0.89); C864(1.05); C238(1.32)  LDD0718  [11]
 LDCM0402  CL15 HCT 116 C953(0.53); C864(1.18); C238(1.34)  LDD0719  [11]
 LDCM0403  CL16 HCT 116 C953(0.72); C238(0.94); C864(1.12)  LDD0720  [11]
 LDCM0404  CL17 HCT 116 C953(0.58); C238(1.07); C864(1.16)  LDD0721  [11]
 LDCM0405  CL18 HCT 116 C953(0.54); C864(1.08); C238(1.63)  LDD0722  [11]
 LDCM0406  CL19 HCT 116 C953(0.57); C864(1.13); C238(1.33)  LDD0723  [11]
 LDCM0407  CL2 HCT 116 C864(0.92); C238(1.02); C953(1.16)  LDD0724  [11]
 LDCM0408  CL20 HCT 116 C953(0.51); C864(1.23); C238(1.60)  LDD0725  [11]
 LDCM0409  CL21 HCT 116 C953(0.44); C238(1.56); C864(1.88)  LDD0726  [11]
 LDCM0410  CL22 HCT 116 C953(0.29); C864(2.10); C238(2.10)  LDD0727  [11]
 LDCM0411  CL23 HCT 116 C953(0.46); C864(1.10); C238(1.65)  LDD0728  [11]
 LDCM0412  CL24 HCT 116 C953(0.39); C864(1.35); C238(1.85)  LDD0729  [11]
 LDCM0413  CL25 HCT 116 C238(1.79); C864(1.50); C953(0.48)  LDD0730  [11]
 LDCM0414  CL26 HCT 116 C238(1.64); C864(1.09); C953(0.50)  LDD0731  [11]
 LDCM0415  CL27 HCT 116 C238(1.82); C864(1.09); C953(0.51)  LDD0732  [11]
 LDCM0416  CL28 HCT 116 C238(1.90); C864(1.24); C953(0.51)  LDD0733  [11]
 LDCM0417  CL29 HCT 116 C238(2.25); C864(1.35); C953(0.44)  LDD0734  [11]
 LDCM0418  CL3 HCT 116 C238(1.09); C864(0.87); C953(0.98)  LDD0735  [11]
 LDCM0419  CL30 HCT 116 C238(1.34); C864(1.02); C953(0.52)  LDD0736  [11]
 LDCM0420  CL31 HCT 116 C238(1.28); C864(1.19); C953(0.64)  LDD0737  [11]
 LDCM0421  CL32 HCT 116 C238(1.36); C864(1.19); C953(0.73)  LDD0738  [11]
 LDCM0422  CL33 HCT 116 C238(1.35); C864(1.17); C953(0.55)  LDD0739  [11]
 LDCM0423  CL34 HCT 116 C238(1.48); C864(1.52); C953(0.48)  LDD0740  [11]
 LDCM0424  CL35 HCT 116 C238(1.51); C864(1.50); C953(0.52)  LDD0741  [11]
 LDCM0425  CL36 HCT 116 C238(1.47); C864(1.42); C953(0.61)  LDD0742  [11]
 LDCM0426  CL37 HCT 116 C238(2.09); C864(1.65); C953(0.44)  LDD0743  [11]
 LDCM0428  CL39 HCT 116 C238(1.55); C864(1.63); C953(0.45)  LDD0745  [11]
 LDCM0429  CL4 HCT 116 C238(1.23); C864(0.85); C953(1.02)  LDD0746  [11]
 LDCM0430  CL40 HCT 116 C238(1.47); C864(1.45); C953(0.54)  LDD0747  [11]
 LDCM0431  CL41 HCT 116 C238(1.58); C864(1.31); C953(0.54)  LDD0748  [11]
 LDCM0432  CL42 HCT 116 C238(1.78); C864(3.35); C953(0.37)  LDD0749  [11]
 LDCM0433  CL43 HCT 116 C238(1.71); C864(1.62); C953(0.46)  LDD0750  [11]
 LDCM0434  CL44 HCT 116 C238(1.57); C864(1.42); C953(0.58)  LDD0751  [11]
 LDCM0435  CL45 HCT 116 C238(1.51); C864(1.62); C953(0.52)  LDD0752  [11]
 LDCM0436  CL46 HCT 116 C238(1.21); C864(0.82); C953(1.35)  LDD0753  [11]
 LDCM0437  CL47 HCT 116 C238(1.30); C864(0.87); C953(0.93)  LDD0754  [11]
 LDCM0438  CL48 HCT 116 C238(1.20); C864(0.70); C953(1.31)  LDD0755  [11]
 LDCM0439  CL49 HCT 116 C238(0.95); C864(0.80); C953(0.96)  LDD0756  [11]
 LDCM0440  CL5 HCT 116 C238(1.41); C864(0.91); C953(0.91)  LDD0757  [11]
 LDCM0441  CL50 HCT 116 C238(1.17); C864(0.84); C953(1.43)  LDD0758  [11]
 LDCM0442  CL51 HCT 116 C238(1.33); C864(0.80); C953(0.95)  LDD0759  [11]
 LDCM0443  CL52 HCT 116 C238(1.59); C864(0.82); C953(0.85)  LDD0760  [11]
 LDCM0444  CL53 HCT 116 C238(1.03); C864(0.89); C953(1.82)  LDD0761  [11]
 LDCM0445  CL54 HCT 116 C238(1.21); C864(0.86); C953(1.09)  LDD0762  [11]
 LDCM0446  CL55 HCT 116 C238(1.08); C864(0.72); C953(1.03)  LDD0763  [11]
 LDCM0447  CL56 HCT 116 C238(1.06); C864(0.88); C953(1.06)  LDD0764  [11]
 LDCM0448  CL57 HCT 116 C238(1.21); C864(0.85); C953(1.35)  LDD0765  [11]
 LDCM0449  CL58 HCT 116 C238(1.14); C864(0.73); C953(1.50)  LDD0766  [11]
 LDCM0450  CL59 HCT 116 C238(1.33); C864(0.87); C953(1.05)  LDD0767  [11]
 LDCM0451  CL6 HCT 116 C238(1.21); C864(1.01); C953(0.85)  LDD0768  [11]
 LDCM0452  CL60 HCT 116 C238(1.60); C864(0.78); C953(0.97)  LDD0769  [11]
 LDCM0453  CL61 HCT 116 C238(1.20); C864(1.02)  LDD0770  [11]
 LDCM0454  CL62 HCT 116 C238(1.07); C864(1.12)  LDD0771  [11]
 LDCM0455  CL63 HCT 116 C238(1.34); C864(1.22)  LDD0772  [11]
 LDCM0456  CL64 HCT 116 C238(1.37); C864(1.55)  LDD0773  [11]
 LDCM0457  CL65 HCT 116 C238(0.94); C864(1.23)  LDD0774  [11]
 LDCM0458  CL66 HCT 116 C238(1.43); C864(1.71)  LDD0775  [11]
 LDCM0459  CL67 HCT 116 C238(1.22); C864(1.48)  LDD0776  [11]
 LDCM0460  CL68 HCT 116 C238(1.50); C864(1.23)  LDD0777  [11]
 LDCM0461  CL69 HCT 116 C238(1.58); C864(1.07)  LDD0778  [11]
 LDCM0462  CL7 HCT 116 C238(1.59); C864(1.30); C953(0.77)  LDD0779  [11]
 LDCM0463  CL70 HCT 116 C238(1.29); C864(1.20)  LDD0780  [11]
 LDCM0464  CL71 HCT 116 C238(1.27); C864(1.36)  LDD0781  [11]
 LDCM0465  CL72 HCT 116 C238(1.40); C864(1.18)  LDD0782  [11]
 LDCM0466  CL73 HCT 116 C238(1.48); C864(1.30)  LDD0783  [11]
 LDCM0467  CL74 HCT 116 C238(1.82); C864(1.30)  LDD0784  [11]
 LDCM0469  CL76 HCT 116 C238(1.16); C864(1.11); C953(1.06)  LDD0786  [11]
 LDCM0470  CL77 HCT 116 C238(1.13); C864(1.21); C953(0.82)  LDD0787  [11]
 LDCM0471  CL78 HCT 116 C238(1.18); C864(1.20); C953(0.86)  LDD0788  [11]
 LDCM0472  CL79 HCT 116 C238(1.62); C864(1.25); C953(0.65)  LDD0789  [11]
 LDCM0473  CL8 HCT 116 C238(2.44); C864(1.70); C953(0.61)  LDD0790  [11]
 LDCM0474  CL80 HCT 116 C238(0.90); C864(0.99); C953(1.05)  LDD0791  [11]
 LDCM0475  CL81 HCT 116 C238(1.43); C864(1.12); C953(0.80)  LDD0792  [11]
 LDCM0476  CL82 HCT 116 C238(1.76); C864(1.53); C953(0.56)  LDD0793  [11]
 LDCM0477  CL83 HCT 116 C238(1.54); C864(1.64); C953(0.64)  LDD0794  [11]
 LDCM0478  CL84 HCT 116 C238(1.86); C864(2.11); C953(0.50)  LDD0795  [11]
 LDCM0479  CL85 HCT 116 C238(1.35); C864(1.34); C953(0.84)  LDD0796  [11]
 LDCM0480  CL86 HCT 116 C238(0.86); C864(1.15); C953(1.08)  LDD0797  [11]
 LDCM0481  CL87 HCT 116 C238(1.23); C864(1.21); C953(0.96)  LDD0798  [11]
 LDCM0482  CL88 HCT 116 C238(1.56); C864(1.30); C953(0.75)  LDD0799  [11]
 LDCM0483  CL89 HCT 116 C238(1.82); C864(2.31); C953(0.51)  LDD0800  [11]
 LDCM0484  CL9 HCT 116 C238(1.38); C864(1.12); C953(0.82)  LDD0801  [11]
 LDCM0485  CL90 HCT 116 C238(0.85); C864(1.00); C953(1.10)  LDD0802  [11]
 LDCM0486  CL91 HCT 116 C238(1.28); C864(1.22); C953(1.07)  LDD0803  [11]
 LDCM0487  CL92 HCT 116 C238(0.89); C864(1.19); C953(1.08)  LDD0804  [11]
 LDCM0488  CL93 HCT 116 C238(1.21); C864(1.05); C953(1.14)  LDD0805  [11]
 LDCM0489  CL94 HCT 116 C238(1.25); C864(1.42); C953(0.99)  LDD0806  [11]
 LDCM0490  CL95 HCT 116 C238(1.25); C864(1.47); C953(0.93)  LDD0807  [11]
 LDCM0491  CL96 HCT 116 C238(1.25); C864(1.25); C953(0.90)  LDD0808  [11]
 LDCM0492  CL97 HCT 116 C238(0.98); C864(1.29); C953(1.02)  LDD0809  [11]
 LDCM0493  CL98 HCT 116 C238(1.05); C864(1.27); C953(0.94)  LDD0810  [11]
 LDCM0494  CL99 HCT 116 C238(1.00); C864(1.33); C953(0.97)  LDD0811  [11]
 LDCM0634  CY-0357 Hep-G2 C864(0.48)  LDD2228  [18]
 LDCM0495  E2913 HEK-293T C1054(1.16); C238(1.05); C60(1.14); C864(0.79)  LDD1698  [34]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C1054(1.31); C864(1.00)  LDD1702  [6]
 LDCM0031  Epigallocatechin gallate HEK-293T 7.52  LDD0183  [8]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [10]
 LDCM0625  F8 Ramos C953(0.54); C1054(1.63); C238(1.62); C864(1.06)  LDD2187  [35]
 LDCM0572  Fragment10 Ramos C953(0.52); C1054(2.53); C238(1.08); C864(1.00)  LDD2189  [35]
 LDCM0573  Fragment11 Ramos C953(2.21); C1054(1.18); C238(20.00); C864(0.33)  LDD2190  [35]
 LDCM0574  Fragment12 Ramos C953(0.57); C1054(1.84); C238(0.72); C864(0.75)  LDD2191  [35]
 LDCM0575  Fragment13 Ramos C953(0.89); C1054(1.41); C238(0.86); C864(1.12)  LDD2192  [35]
 LDCM0576  Fragment14 Ramos C953(0.67); C1054(0.79); C238(0.88); C864(0.86)  LDD2193  [35]
 LDCM0579  Fragment20 Ramos C953(0.45); C1054(1.33); C238(0.74); C864(0.91)  LDD2194  [35]
 LDCM0580  Fragment21 Ramos C953(0.81); C1054(0.99); C238(0.99); C864(0.79)  LDD2195  [35]
 LDCM0582  Fragment23 Ramos C953(1.06); C1054(1.13); C238(0.91); C864(1.02)  LDD2196  [35]
 LDCM0578  Fragment27 Ramos C953(0.94); C1054(1.35); C238(1.05); C864(1.12)  LDD2197  [35]
 LDCM0586  Fragment28 Ramos C953(0.72); C1054(0.73); C238(0.73); C864(1.00)  LDD2198  [35]
 LDCM0588  Fragment30 Ramos C953(0.74); C1054(1.92); C238(1.22); C864(1.44)  LDD2199  [35]
 LDCM0589  Fragment31 Ramos C953(0.93); C1054(1.27); C238(1.13); C864(0.88)  LDD2200  [35]
 LDCM0590  Fragment32 Ramos C953(0.40); C1054(3.66); C238(1.94); C864(1.08)  LDD2201  [35]
 LDCM0468  Fragment33 HCT 116 C238(1.63); C864(1.11)  LDD0785  [11]
 LDCM0596  Fragment38 Ramos C953(1.14); C1054(1.34); C238(0.74); C864(0.64)  LDD2203  [35]
 LDCM0566  Fragment4 Ramos C953(0.52); C1054(1.01); C238(0.64); C864(1.19)  LDD2184  [35]
 LDCM0427  Fragment51 HCT 116 C238(1.98); C864(2.33); C953(0.38)  LDD0744  [11]
 LDCM0610  Fragment52 Ramos C953(1.14); C1054(2.91); C238(1.01); C864(1.34)  LDD2204  [35]
 LDCM0614  Fragment56 Ramos C953(0.88); C1054(1.91); C238(1.18); C864(1.09)  LDD2205  [35]
 LDCM0569  Fragment7 Ramos C953(0.59); C1054(1.16); C238(0.73); C864(1.14)  LDD2186  [35]
 LDCM0571  Fragment9 Ramos C953(0.44); C1054(1.55); C238(0.74); C864(1.02)  LDD2188  [35]
 LDCM0107  IAA HeLa H1039(0.00); H1088(0.00); H192(0.00); H581(0.00)  LDD0221  [26]
 LDCM0022  KB02 HCT 116 C864(1.87)  LDD0080  [11]
 LDCM0023  KB03 HCT 116 C864(1.19)  LDD0081  [11]
 LDCM0024  KB05 HCT 116 C864(2.00)  LDD0082  [11]
 LDCM0030  Luteolin HEK-293T 5.67  LDD0182  [8]
 LDCM0109  NEM HeLa H1039(0.00); H1088(0.00); H651(0.00); H581(0.00)  LDD0223  [26]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C1054(0.65)  LDD2092  [6]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C1054(1.05)  LDD2100  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C1054(0.79)  LDD2104  [6]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C1054(1.13)  LDD2105  [6]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C1054(0.63)  LDD2106  [6]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C1054(0.96)  LDD2108  [6]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C1054(1.16)  LDD2110  [6]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C1054(0.60)  LDD2114  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C897(1.50)  LDD1700  [6]
 LDCM0628  OTUB2-COV-1 HEK-293T C864(0.58)  LDD2207  [36]
 LDCM0029  Quercetin HEK-293T 5.30  LDD0181  [8]
 LDCM0131  RA190 MM1.R C864(1.77)  LDD0304  [37]
 LDCM0019  Staurosporine Hep-G2 N.A.  LDD0083  [32]
 LDCM0003  Sulforaphane MCF-7 2.06  LDD0042  [7]
 LDCM0021  THZ1 HCT 116 C864(0.97); C238(1.18)  LDD2173  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein KASH5 (KASH5) . Q8N6L0

References

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3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.
Mass spectrometry data entry: PXD006279
8 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
9 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
10 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
11 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
12 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
13 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
14 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
15 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
16 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
17 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
18 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
19 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
20 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
21 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
22 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
23 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
24 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
25 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
26 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
27 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
28 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
29 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
30 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
31 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
32 Comprehensive identification of staurosporine-binding kinases in the hepatocyte cell line HepG2 using Capture Compound Mass Spectrometry (CCMS). J Proteome Res. 2010 Feb 5;9(2):806-17. doi: 10.1021/pr9007333.
33 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
34 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
35 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
36 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
37 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.