Details of the Target

General Information of Target

Target ID LDTP00837
Target Name Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1)
Gene Name BUB1
Gene ID 699
Synonyms
BUB1L; Mitotic checkpoint serine/threonine-protein kinase BUB1; hBUB1; EC 2.7.11.1; BUB1A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDTPENVLQMLEAHMQSYKGNDPLGEWERYIQWVEENFPENKEYLITLLEHLMKEFLDKK
KYHNDPRFISYCLKFAEYNSDLHQFFEFLYNHGIGTLSSPLYIAWAGHLEAQGELQHASA
VLQRGIQNQAEPREFLQQQYRLFQTRLTETHLPAQARTSEPLHNVQVLNQMITSKSNPGN
NMACISKNQGSELSGVISSACDKESNMERRVITISKSEYSVHSSLASKVDVEQVVMYCKE
KLIRGESEFSFEELRAQKYNQRRKHEQWVNEDRHYMKRKEANAFEEQLLKQKMDELHKKL
HQVVETSHEDLPASQERSEVNPARMGPSVGSQQELRAPCLPVTYQQTPVNMEKNPREAPP
VVPPLANAISAALVSPATSQSIAPPVPLKAQTVTDSMFAVASKDAGCVNKSTHEFKPQSG
AEIKEGCETHKVANTSSFHTTPNTSLGMVQATPSKVQPSPTVHTKEALGFIMNMFQAPTL
PDISDDKDEWQSLDQNEDAFEAQFQKNVRSSGAWGVNKIISSLSSAFHVFEDGNKENYGL
PQPKNKPTGARTFGERSVSRLPSKPKEEVPHAEEFLDDSTVWGIRCNKTLAPSPKSPGDF
TSAAQLASTPFHKLPVESVHILEDKENVVAKQCTQATLDSCEENMVVPSRDGKFSPIQEK
SPKQALSSHMYSASLLRLSQPAAGGVLTCEAELGVEACRLTDTDAAIAEDPPDAIAGLQA
EWMQMSSLGTVDAPNFIVGNPWDDKLIFKLLSGLSKPVSSYPNTFEWQCKLPAIKPKTEF
QLGSKLVYVHHLLGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPWEFYIGTQLMER
LKPSMQHMFMKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMR
MLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGT
IFTAKCETSGFQCVEMLSNKPWNYQIDYFGVAATVYCMLFGTYMKVKNEGGECKPEGLFR
RLPHLDMWNEFFHVMLNIPDCHHLPSLDLLRQKLKKVFQQHYTNKIRALRNRLIVLLLEC
KRSRK
Target Type
Patented-recorded
Target Bioclass
Enzyme
Family
Protein kinase superfamily, Ser/Thr protein kinase family, BUB1 subfamily
Subcellular location
Nucleus
Function
Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A. Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis.
TTD ID
T20953
Uniprot ID
O43683
DrugMap ID
TT78309
Ensemble ID
ENST00000302759.11
HGNC ID
HGNC:1148
ChEMBL ID
CHEMBL1772932

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HT115 SNV: p.T441P .
IGROV1 SNV: p.Q155R .
JURKAT SNV: p.E692K Compound 10    Probe Info 
LN229 SNV: p.H1033N .
MCC26 SNV: p.P338Q .
OZ SNV: p.E696G .
RKO SNV: p.Y259C; p.H265N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.80  LDD0402  [1]
BTD
 Probe Info  		C184(0.91)  LDD2136  [2]
DA-P3
 Probe Info  		6.11  LDD0179  [3]
AHL-Pu-1
 Probe Info  		C339(10.40)  LDD0168  [4]
DBIA
 Probe Info  		C633(1.15); C641(1.15); C689(1.10); C698(1.10)  LDD0078  [5]
ATP probe
 Probe Info  		N.A.  LDD0199  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		C769(0.00); C238(0.00)  LDD0037  [7]
NAIA_4
 Probe Info  		C238(0.00); C339(0.00)  LDD2226  [8]
NAIA_5
 Probe Info  		N.A.  LDD2225  [8]
Compound 10
 Probe Info  		N.A.  LDD2216  [9]
IPM
 Probe Info  		C407(0.00); C184(0.00)  LDD0147  [10]
VSF
 Probe Info  		N.A.  LDD0007  [11]
AOyne
 Probe Info  		13.80  LDD0443  [12]
PAL-AfBPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C187
 Probe Info  		36.25  LDD1865  [13]
C191
 Probe Info  		30.27  LDD1868  [13]
C193
 Probe Info  		13.64  LDD1869  [13]
C362
 Probe Info  		29.04  LDD2023  [13]
C363
 Probe Info  		16.80  LDD2024  [13]
C364
 Probe Info  		16.00  LDD2025  [13]
C366
 Probe Info  		5.66  LDD2027  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C339(10.40)  LDD0168  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C339(10.54)  LDD0169  [4]
 LDCM0214  AC1 HCT 116 C633(0.83); C641(0.83); C1013(0.89); C1080(1.21)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C633(0.91); C641(0.91); C1080(1.32); C238(0.66)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C633(0.87); C641(0.87); C339(1.01); C407(0.90)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C633(0.93); C641(0.93); C339(0.88); C407(0.98)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C633(0.96); C641(0.96); C339(1.03); C407(0.87)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C633(1.08); C641(1.08); C339(1.20); C407(1.35)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C633(0.95); C641(0.95); C339(1.03); C407(1.04)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C633(1.03); C641(1.03); C339(1.01); C407(1.07)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C633(1.11); C641(1.11); C339(1.00); C407(1.05)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C633(0.91); C641(0.93); C339(1.33); C407(0.99)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C633(0.87); C641(0.83); C339(0.58); C407(1.44)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C633(0.87); C641(0.88); C339(0.87); C407(0.96)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C633(0.99); C641(0.99); C1080(1.32); C238(0.58)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C633(0.90); C641(0.88); C339(0.70); C407(1.03)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C633(1.10); C641(1.07); C339(0.93); C407(1.02)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C633(0.96); C641(0.93); C339(1.14); C407(0.95)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C633(0.88); C641(0.88); C1080(1.31); C407(0.96)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C633(1.09); C641(1.13); C1080(1.28); C407(1.21)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C633(1.02); C641(1.09); C1080(1.36); C407(1.15)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C633(1.29); C641(1.27); C1080(1.43); C407(1.10)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C633(1.00); C641(1.01); C1080(1.39); C407(1.11)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C633(1.02); C641(1.07); C1080(1.26); C407(1.07)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C633(1.07); C641(1.09); C1080(1.23); C407(1.20)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C633(0.92); C641(0.92); C1080(1.11); C238(0.68)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C633(1.25); C641(1.29); C1080(1.47); C407(1.16)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C633(1.01); C641(1.02); C1080(1.35); C407(1.20)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C633(1.08); C641(1.15); C1080(1.21); C407(1.22)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C633(1.02); C641(1.01); C1080(1.17); C407(1.19)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C633(0.99); C641(1.03); C1080(1.26); C407(0.89)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C633(1.09); C641(1.20); C1080(1.12); C407(1.15)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C633(1.16); C641(1.22); C1080(1.58); C407(1.24)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C633(1.09); C641(1.15); C1080(1.59); C407(1.18)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C633(0.89); C641(0.89); C1080(1.36); C238(0.91)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C633(0.73); C641(0.73); C1080(0.82); C238(0.96)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C633(0.86); C641(0.86); C1080(1.09); C238(0.96)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C633(0.98); C641(0.98); C1080(0.94); C238(1.07)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C633(0.75); C641(0.75); C1080(0.89); C238(1.14)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C633(0.79); C641(0.79); C1080(1.00); C238(0.97)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C633(0.78); C641(0.78); C1080(1.11); C238(0.96)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C633(0.70); C641(0.70); C1080(1.16); C238(1.14)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C633(0.83); C641(0.83); C1080(1.00); C238(1.08)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C633(0.68); C641(0.68); C1080(0.89); C238(0.93)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C633(0.79); C641(0.79); C1080(1.01); C238(1.04)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C633(0.79); C641(0.79); C1080(0.98); C238(1.11)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C633(0.95); C641(0.95); C1080(1.32); C238(0.90)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C633(0.81); C641(0.81); C1080(1.09); C238(1.00)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C633(0.73); C641(0.73); C1080(1.08); C238(1.19)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C633(0.65); C641(0.65); C1080(0.84); C238(0.96)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C633(1.14); C641(1.14); C1013(1.13); C201(0.94)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C72(0.79); C698(1.06); C201(1.08); C339(1.08)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C72(0.76); C698(0.83); C689(0.88); C339(0.93)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C339(0.88); C72(0.88); C689(0.89); C698(0.94)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C72(0.76); C689(0.93); C698(0.95); C769(0.96)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C339(0.75); C72(0.79); C689(0.95); C1013(1.12)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C339(0.81); C72(0.83); C769(1.03); C689(1.11)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C238(0.80); C427(0.88); C689(0.89); C698(0.89)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C72(0.80); C689(0.85); C698(0.91); C339(0.92)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C72(0.92); C339(0.92); C427(0.94); C689(0.95)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C339(0.84); C689(0.87); C72(0.91); C698(0.95)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C72(0.76); C339(0.78); C698(1.14); C689(1.16)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C633(1.33); C641(1.34); C1013(1.11); C201(1.22)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C633(1.38); C641(1.39); C1013(1.20); C201(1.33)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C633(1.09); C641(1.10); C1013(1.28); C201(1.11)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C633(1.47); C641(1.46); C1013(1.20); C201(1.16)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C184(0.59); C238(0.75); C72(0.84); C633(0.89)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C238(0.64); C1080(0.82); C184(0.83); C72(0.87)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C238(0.69); C72(0.75); C184(0.80); C1080(0.95)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C427(0.59); C633(0.80); C641(0.80); C689(0.89)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C184(0.68); C72(0.86); C238(0.88); C1080(0.92)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C184(0.60); C238(0.74); C1080(0.97); C72(0.97)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C184(0.68); C238(0.85); C1080(0.87); C72(0.97)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C184(0.56); C238(0.78); C1080(0.79); C72(0.81)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C184(0.62); C238(0.80); C72(0.82); C427(0.89)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C238(0.69); C769(0.97); C427(0.99); C689(1.01)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C238(0.81); C769(0.86); C689(0.93); C698(0.93)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C769(0.91); C238(0.92); C689(0.98); C698(0.98)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C238(0.78); C689(0.92); C698(0.92); C427(1.01)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C769(0.96); C427(0.96); C689(1.06); C698(1.06)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C427(0.51); C633(0.71); C641(0.71); C689(0.78)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C633(1.01); C641(1.01); C427(1.02); C689(1.05)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C427(0.86); C769(0.91); C689(0.91); C698(0.91)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C427(0.94); C769(0.95); C633(0.99); C641(0.99)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C769(0.95); C238(1.01); C427(1.03); C689(1.15)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C769(0.90); C689(1.00); C698(1.00); C427(1.10)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C689(0.88); C698(0.88); C427(0.91); C407(0.99)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C72(0.91); C427(0.92); C407(0.94); C633(1.04)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C427(0.89); C72(0.91); C407(0.93); C689(1.00)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C407(0.86); C427(0.88); C72(0.89); C633(0.99)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C72(0.66); C633(1.02); C641(1.02); C427(1.07)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C427(0.47); C633(0.72); C641(0.72); C339(0.81)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C72(0.82); C427(1.03); C769(1.08); C633(1.08)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C72(0.86); C427(1.00); C769(1.04); C407(1.06)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C72(0.89); C427(0.97); C407(0.99); C689(1.00)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C72(0.94); C427(0.96); C407(1.06); C769(1.07)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C72(0.88); C427(0.97); C689(1.00); C698(1.00)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C72(0.78); C427(1.03); C769(1.10); C407(1.13)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C427(0.93); C633(0.99); C641(0.99); C72(1.03)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C72(0.74); C689(0.87); C698(0.87); C633(0.97)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C72(0.70); C633(0.87); C641(0.87); C769(0.98)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C72(0.78); C689(1.09); C698(1.09); C427(1.12)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C427(0.47); C633(0.65); C641(0.65); C689(0.76)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C72(0.87); C689(0.90); C698(0.90); C427(1.00)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C427(0.65); C72(0.94); C633(0.96); C641(0.96)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C427(0.70); C769(0.92); C72(0.93); C689(0.94)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C72(0.77); C427(0.92); C769(0.97); C689(1.14)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C427(0.86); C689(0.91); C698(0.91); C72(0.94)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C72(0.85); C769(1.01); C427(1.07); C633(1.18)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C72(0.98); C769(1.11); C689(1.23); C698(1.23)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C427(0.68); C633(0.86); C641(0.86); C689(0.87)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C427(0.68); C689(0.89); C698(0.89); C633(0.91)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C427(0.73); C689(0.91); C698(0.91); C633(0.91)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C689(0.92); C698(0.92); C633(0.95); C641(0.95)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C427(0.81); C633(0.84); C641(0.84); C689(0.88)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C427(0.64); C633(0.83); C641(0.83); C689(0.85)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C427(0.72); C689(0.87); C698(0.87); C633(0.95)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C427(0.76); C633(0.90); C641(0.90); C689(0.97)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C427(0.81); C633(0.87); C641(0.87); C689(0.97)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C427(0.71); C633(0.74); C641(0.74); C1013(0.91)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C633(0.71); C641(0.71); C427(0.71); C689(0.82)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C633(0.77); C641(0.77); C427(0.89); C1013(0.96)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C72(0.99); C184(1.00); C689(1.01); C698(1.01)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C184(0.65); C689(0.89); C698(0.89); C201(1.01)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C633(0.83); C641(0.83); C238(0.85); C407(0.99)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C184(0.67); C689(0.77); C698(0.77); C201(0.88)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C769(0.84); C184(0.88); C689(0.90); C698(0.90)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C769(0.85); C184(0.92); C427(1.00); C689(1.03)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C689(0.89); C698(0.89); C769(0.89); C72(1.08)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C689(0.90); C698(0.90); C769(0.91); C72(1.07)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C769(0.97); C689(0.98); C698(0.98); C72(1.16)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C769(0.88); C184(0.98); C689(1.00); C698(1.00)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C72(0.85); C689(0.91); C698(0.91); C769(1.05)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C184(0.83); C769(0.87); C689(0.90); C698(0.90)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C184(0.77); C427(0.92); C769(0.95); C689(0.98)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C689(0.81); C698(0.81); C238(0.87); C769(0.94)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C184(0.89); C769(0.92); C689(0.92); C698(0.92)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C184(0.84); C689(0.89); C698(0.89); C427(0.94)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C689(0.73); C698(0.73); C769(0.89); C201(0.94)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C689(1.40); C698(1.40); C633(1.54); C641(1.54)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C689(1.31); C698(1.31); C633(1.47); C641(1.47)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C689(1.16); C698(1.16); C1080(1.24); C633(1.26)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C689(1.20); C698(1.20); C407(1.23); C633(1.36)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C1080(1.00); C407(1.07); C689(1.21); C698(1.21)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C407(1.14); C1080(1.19); C689(1.21); C698(1.21)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C689(1.25); C698(1.25); C633(1.33); C641(1.33)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C1080(0.98); C407(1.08); C689(1.15); C698(1.15)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C689(1.44); C698(1.44); C633(1.48); C641(1.48)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C633(1.46); C641(1.46); C689(1.55); C698(1.55)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C1080(1.12); C689(1.26); C698(1.26); C407(1.43)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C1080(1.13); C689(1.18); C698(1.18); C407(1.31)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C689(1.10); C698(1.10); C633(1.15); C641(1.15)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C689(1.24); C698(1.24); C407(1.38); C633(1.47)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C689(1.32); C698(1.32); C633(1.38); C641(1.38)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C72(0.52); C689(1.07); C698(1.07); C633(1.16)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C72(0.68); C339(0.73); C407(0.80); C689(0.83)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C633(0.93); C641(0.93); C1080(1.21); C238(0.74)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C238(0.73); C689(0.91); C698(0.91); C769(0.92)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C689(0.83); C698(0.83); C238(0.86); C769(0.94)  LDD0592  [5]
 LDCM0156  Aniline NCI-H1299 9.29  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C633(1.15); C641(1.15); C689(1.10); C698(1.10)  LDD0078  [5]
 LDCM0102  BDHI 8 Jurkat C1041(18.67)  LDD0204  [14]
 LDCM0087  Capsaicin HEK-293T 11.83  LDD0185  [3]
 LDCM0632  CL-Sc Hep-G2 C427(2.25); C238(1.09)  LDD2227  [8]
 LDCM0367  CL1 HCT 116 C201(0.69); C427(0.70); C339(0.74); C407(0.81)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C427(0.55); C201(0.92); C769(0.92); C633(1.05)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C427(0.47); C633(0.76); C641(0.76); C689(0.82)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C238(0.82); C769(0.88); C689(0.94); C698(0.94)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C238(0.61); C689(0.78); C698(0.78); C427(0.85)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C238(0.64); C689(0.80); C698(0.80); C427(0.82)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C689(0.83); C698(0.83); C427(0.85); C407(0.88)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C238(0.75); C184(0.79); C633(0.94); C641(0.94)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C184(0.63); C238(0.69); C72(0.99); C633(1.06)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C238(0.72); C184(0.82); C633(0.97); C641(0.97)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C184(0.66); C238(0.71); C633(0.97); C641(0.97)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C184(0.73); C238(0.82); C72(0.87); C769(0.99)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C427(0.42); C201(0.74); C769(0.78); C633(1.06)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C184(0.59); C238(0.68); C72(0.73); C769(1.05)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C184(0.61); C238(0.66); C72(0.82); C633(0.89)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C427(0.79); C238(0.89); C689(0.93); C698(0.93)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C427(0.92); C689(0.98); C698(0.98); C769(1.06)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C427(0.72); C769(0.85); C633(1.00); C641(1.00)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C427(0.73); C769(0.87); C689(0.91); C698(0.91)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C427(0.80); C769(0.91); C633(0.92); C641(0.92)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C72(0.76); C689(1.12); C698(1.12); C769(1.13)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C72(0.87); C769(0.94); C633(0.99); C641(0.99)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C72(0.87); C769(1.03); C427(1.06); C633(1.16)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C427(0.55); C769(0.99); C201(1.15); C633(1.18)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C72(0.77); C427(0.95); C689(1.03); C698(1.03)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C72(0.75); C769(1.00); C689(1.00); C698(1.00)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C72(0.80); C633(0.81); C641(0.81); C427(0.85)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C72(0.71); C427(0.99); C769(1.01); C633(1.13)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C72(0.76); C769(0.89); C427(0.94); C633(0.99)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C689(0.78); C698(0.78); C427(0.82); C633(0.85)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C427(0.63); C1013(0.72); C633(0.72); C641(0.72)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C633(0.76); C641(0.76); C427(0.82); C689(0.88)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C427(0.84); C633(0.89); C641(0.89); C1013(0.98)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C427(0.44); C201(0.68); C689(0.80); C698(0.80)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C427(0.49); C633(0.88); C641(0.88); C201(0.88)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C427(0.41); C201(0.68); C633(0.85); C641(0.85)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C1080(0.87); C407(0.89); C427(0.96); C238(1.02)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C184(0.74); C427(0.78); C407(0.79); C1080(0.80)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C427(0.88); C184(0.89); C72(0.94); C1080(1.02)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C427(0.89); C184(0.90); C689(0.94); C698(0.94)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C339(0.72); C427(0.81); C407(0.82); C633(0.88)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C427(0.82); C184(0.91); C72(1.05); C407(1.19)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C427(0.58); C184(0.71); C72(0.94); C407(1.12)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C427(0.65); C184(0.74); C72(1.03); C689(1.26)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C427(0.87); C184(0.97); C407(1.13); C1080(1.19)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C427(0.71); C72(0.93); C184(0.96); C407(1.34)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C633(1.25); C641(1.25); C1080(1.20); C184(0.71)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C633(1.20); C641(1.20); C1080(1.06); C184(0.82)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C633(1.10); C641(1.10); C1080(1.09); C184(0.77)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C633(1.17); C641(1.17); C1080(1.12); C184(0.80)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C633(1.27); C641(1.27); C1080(1.20); C184(0.79)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C633(0.88); C641(0.88); C201(0.97); C339(0.98)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C633(1.28); C641(1.28); C1080(1.06); C184(0.77)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C633(0.83); C641(0.83); C1080(1.03); C201(0.68)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C633(0.88); C641(0.88); C1080(0.97); C184(0.94)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C633(0.90); C641(0.90); C1080(0.92); C184(0.86)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C633(0.88); C641(0.88); C1080(1.28); C184(0.89)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C633(1.32); C641(1.32); C1080(1.38); C184(0.99)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C633(0.93); C641(0.93); C1080(1.16); C184(0.86)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C633(0.99); C641(0.99); C1080(1.44); C184(1.09)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C633(0.96); C641(0.96); C1080(1.24); C184(0.98)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C633(0.94); C641(0.94); C201(0.63); C339(1.01)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C633(1.15); C641(1.15); C1080(1.13); C184(0.88)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C633(1.04); C641(1.04); C1080(1.27); C184(1.05)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C633(1.17); C641(1.17); C1080(1.72); C184(0.74)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C633(1.13); C641(1.13); C1080(1.49); C184(1.06)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C633(1.10); C641(1.10); C1080(1.32); C184(0.98)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C633(1.09); C641(1.09); C1080(1.49); C184(0.98)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C633(0.78); C641(0.78); C1013(1.03); C1080(0.79)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C633(0.77); C641(0.77); C1013(1.08); C1080(0.74)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C633(0.94); C641(0.94); C1013(1.03); C1080(0.71)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C633(0.90); C641(0.90); C1013(1.21); C1080(0.88)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C633(1.00); C641(1.00); C201(0.87); C339(1.23)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C633(0.98); C641(0.98); C1013(0.96); C1080(0.79)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C633(1.12); C641(1.12); C1013(1.21); C1080(0.84)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C633(0.83); C641(0.83); C1013(1.14); C1080(0.86)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C633(0.86); C641(0.86); C1013(0.92); C1080(0.62)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C633(0.99); C641(0.99); C1013(0.93); C1080(0.70)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C633(0.86); C641(0.86); C1013(1.04); C1080(0.77)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C633(0.91); C641(0.91); C1013(0.99); C1080(0.87)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C633(0.64); C641(0.64); C1013(0.86); C1080(0.70)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C633(0.96); C641(0.96); C1013(1.14); C1080(0.75)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C633(0.93); C641(0.93); C1013(1.08); C1080(0.87)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C633(0.97); C641(0.97); C201(0.82); C339(1.03)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C633(0.82); C641(0.82); C1013(1.18); C1080(0.84)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C633(1.00); C641(1.00); C1080(1.14); C184(0.82)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C633(0.91); C641(0.91); C1080(0.97); C184(1.15)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C633(0.93); C641(0.93); C1080(1.09); C184(0.88)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C633(0.82); C641(0.82); C1080(1.10); C184(0.74)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C633(0.83); C641(0.83); C1080(1.25); C184(0.73)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C633(0.88); C641(0.88); C1080(1.44); C184(0.86)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C633(0.97); C641(0.97); C1080(1.48); C184(0.78)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C633(0.78); C641(0.78); C1080(1.16); C184(0.77)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C633(0.82); C641(0.82); C1080(1.00); C184(0.89)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C633(1.05); C641(1.05); C201(0.76); C339(1.45)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C633(0.91); C641(0.91); C1080(1.01); C184(0.80)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C633(1.07); C641(1.07); C1080(1.13); C184(0.83)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C633(0.95); C641(0.95); C1080(1.00); C184(0.82)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C633(0.86); C641(0.86); C1080(1.35); C184(0.84)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C633(0.94); C641(0.94); C1080(1.21); C184(0.87)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C633(0.94); C641(0.94); C1080(1.24); C184(0.90)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C633(0.79); C641(0.79); C1080(0.87); C184(1.01)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C633(1.00); C641(1.00); C1080(1.22); C184(0.93)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C633(0.92); C641(0.92); C1080(1.63); C184(0.94)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C633(1.19); C641(1.19); C201(0.63); C339(1.39)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C633(0.83); C641(0.83); C1080(1.12); C184(1.10)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C633(0.88); C641(0.88); C1080(1.31); C184(0.93)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C633(0.98); C641(0.98); C1080(1.99); C184(0.92)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C633(0.91); C641(0.91); C1080(1.88); C184(0.96)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C633(1.05); C641(1.05); C1080(2.33); C184(0.90)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C633(0.82); C641(0.82); C1080(1.38); C184(0.98)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C633(0.69); C641(0.69); C1080(1.11); C184(0.91)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C633(0.70); C641(0.70); C1080(1.40); C184(0.84)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C633(1.02); C641(1.02); C1080(1.97); C184(0.99)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C633(1.35); C641(1.35); C1080(2.80); C184(0.95)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C633(0.96); C641(0.96); C201(0.76); C339(1.19)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C633(0.62); C641(0.62); C1080(0.82); C184(0.77)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C633(0.84); C641(0.84); C1013(1.03); C1080(1.09)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C633(0.82); C641(0.82); C1013(1.00); C1080(1.06)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C633(0.78); C641(0.78); C1013(0.92); C1080(0.98)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C633(0.82); C641(0.82); C1013(0.82); C1080(1.43)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C633(0.83); C641(0.83); C1013(0.99); C1080(1.39)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C633(0.94); C641(0.94); C1013(0.90); C1080(1.12)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C633(0.77); C641(0.77); C1013(1.01); C1080(1.17)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C633(0.73); C641(0.73); C1013(0.98); C1080(1.24)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C633(0.74); C641(0.74); C1013(1.13); C1080(1.28)  LDD0811  [5]
 LDCM0634  CY-0357 Hep-G2 C339(0.60)  LDD2228  [8]
 LDCM0027  Dopamine HEK-293T 6.11  LDD0179  [3]
 LDCM0495  E2913 HEK-293T C1013(1.03); C769(0.73); C72(0.68); C427(1.02)  LDD1698  [15]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C184(2.04)  LDD1702  [2]
 LDCM0625  F8 Ramos C339(1.18); C769(1.84)  LDD2187  [16]
 LDCM0573  Fragment11 Ramos C769(4.51)  LDD2190  [16]
 LDCM0574  Fragment12 Ramos C339(1.01); C769(1.44)  LDD2191  [16]
 LDCM0575  Fragment13 Ramos C339(0.66); C769(1.65)  LDD2192  [16]
 LDCM0576  Fragment14 Ramos C339(1.05); C769(0.71)  LDD2193  [16]
 LDCM0579  Fragment20 Ramos C769(2.63)  LDD2194  [16]
 LDCM0580  Fragment21 Ramos C339(0.73); C769(1.17)  LDD2195  [16]
 LDCM0582  Fragment23 Ramos C339(1.40); C769(1.87)  LDD2196  [16]
 LDCM0578  Fragment27 Ramos C339(0.94)  LDD2197  [16]
 LDCM0586  Fragment28 Ramos C339(0.81); C769(0.77)  LDD2198  [16]
 LDCM0588  Fragment30 Ramos C339(0.79); C769(1.10)  LDD2199  [16]
 LDCM0589  Fragment31 Ramos C339(0.64); C769(0.89)  LDD2200  [16]
 LDCM0590  Fragment32 Ramos C339(1.26)  LDD2201  [16]
 LDCM0468  Fragment33 HCT 116 C633(0.85); C641(0.85); C1080(1.09); C184(0.78)  LDD0785  [5]
 LDCM0596  Fragment38 Ramos C339(0.83); C769(2.16)  LDD2203  [16]
 LDCM0427  Fragment51 HCT 116 C633(1.32); C641(1.32); C1080(1.54); C184(0.91)  LDD0744  [5]
 LDCM0610  Fragment52 Ramos C339(0.82)  LDD2204  [16]
 LDCM0614  Fragment56 Ramos C339(0.93); C769(3.38)  LDD2205  [16]
 LDCM0569  Fragment7 Ramos C769(0.82)  LDD2186  [16]
 LDCM0022  KB02 HCT 116 C689(5.20); C698(5.20); C184(2.23); C427(1.37)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C689(2.81); C698(2.81); C184(1.52); C427(1.02)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C689(3.75); C698(3.75); C184(3.08); C427(1.28)  LDD0082  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C184(0.91)  LDD2136  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C1013(0.82)  LDD2137  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C184(1.43)  LDD2140  [2]
 LDCM0032  Oleacein HEK-293T 7.02  LDD0184  [3]
 LDCM0029  Quercetin HEK-293T 12.92  LDD0181  [3]
 LDCM0021  THZ1 HCT 116 C689(1.04); C698(1.04); C633(1.23); C641(1.23)  LDD2173  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B) Ser/Thr protein kinase family O60566
E3 ubiquitin-protein ligase ARIH2 (ARIH2) RBR family O95376
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Adapter molecule crk (CRK) CRK family P46108
Mitotic checkpoint protein BUB3 (BUB3) WD repeat BUB3 family O43684
Kinetochore scaffold 1 (KNL1) . Q8NG31

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pmid24900824c2-1-1 Small molecular drug D09BXA
Pmid24900824c2-13-1 Small molecular drug D0F9DD
Pmid24900824c2-3-1 Small molecular drug D0JP7S
Pmid24900824c2-3-2 Small molecular drug D0P4YY
Patented
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Schembl16322760 Small molecular drug D01EUT
Schembl16365841 Small molecular drug D0I3PZ
Schembl17766424 Small molecular drug D03RBY

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
14 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578