Details of the Target

General Information of Target

Target ID LDTP04435
Target Name Interleukin-1 receptor-associated kinase 1 (IRAK1)
Gene Name IRAK1
Gene ID 3654
Synonyms
IRAK; Interleukin-1 receptor-associated kinase 1; IRAK-1; EC 2.7.11.1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQFAALIVRDQTELRLCE
RSGQRTASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPAPLPSPGTTAPRPSS
IPAPAEAEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPAPSSTK
PGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKR
LKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRL
HCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFG
LARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAG
QRAVKTHGARTKYLKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDP
RPGPCPPELGLGLGQLACCCLHRRAKRRPPMTQVYERLEKLQAVVAGVPGHSEAASCIPP
SPQENSYVSSTGRAHSGAAPWQPLAAPSGASAQAAEQLQRGPNQPVESDESLGGLSAALR
SWHLTPSCPLDPAPLREAGCPQGDTAGESSWGSGPGSRPTAVEGLALGSSASSSSEPPQI
IINPARQKMVQKLALYEDGALDSLQLLSSSSLPGLGLEQDRQGPEESDEFQS
Target Type
Patented-recorded
Target Bioclass
Enzyme
Family
Protein kinase superfamily, TKL Ser/Thr protein kinase family, Pelle subfamily
Subcellular location
Cytoplasm
Function
Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3.
TTD ID
T63846
Uniprot ID
P51617
DrugMap ID
TTXAJWN
Ensemble ID
ENST00000369974.6
HGNC ID
HGNC:6112
ChEMBL ID
CHEMBL3357

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HSC4 SNV: p.Q91K .
IGROV1 SNV: p.P7R .
MCC13 SNV: p.S333N .
MDAMB453 SNV: p.S568L .
MOLT4 SNV: p.C59Y .
OVCAR4 SNV: p.S607R .
TOV21G SNV: p.Q513K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.84  LDD0402  [1]
STPyne
 Probe Info  		K425(2.18)  LDD0277  [2]
Sulforaphane-probe2
 Probe Info  		2.80  LDD0042  [3]
DA-P3
 Probe Info  		12.68  LDD0179  [4]
AHL-Pu-1
 Probe Info  		C43(2.89)  LDD0168  [5]
HPAP
 Probe Info  		3.43  LDD0062  [6]
DBIA
 Probe Info  		C302(1.48); C307(1.48)  LDD0078  [7]
ATP probe
 Probe Info  		N.A.  LDD0199  [8]
IA-alkyne
 Probe Info  		C43(0.00); C225(0.00); C302(0.00)  LDD0165  [9]
NAIA_4
 Probe Info  		C43(0.00); C225(0.00); C620(0.00)  LDD2226  [10]
IPM
 Probe Info  		N.A.  LDD0005  [11]
AOyne
 Probe Info  		15.00  LDD0443  [12]
NAIA_5
 Probe Info  		N.A.  LDD2223  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C43(2.89)  LDD0168  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C43(2.27)  LDD0169  [5]
 LDCM0214  AC1 HCT 116 C225(0.91); C302(0.92); C307(0.77)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C225(1.44); C302(1.05); C307(1.02)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C225(1.18); C302(1.13); C307(1.13)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C225(1.12); C302(1.24); C307(1.29)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C225(1.09); C302(1.07); C307(1.10)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C225(1.52); C302(1.51); C307(1.54)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C225(1.21); C302(1.25); C307(1.28)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C225(1.38); C302(1.31); C307(1.31)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C225(1.53); C302(1.42); C307(1.41)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C225(1.28); C302(1.05); C307(1.20)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C225(1.01); C302(1.72); C307(1.29)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C225(0.88); C302(1.30); C307(1.12)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C225(1.46); C302(1.16); C307(1.15)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C225(0.96); C302(1.24); C307(1.10)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C225(0.98); C302(1.48); C307(1.20)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C225(1.11); C302(1.25); C307(1.25)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C225(1.11); C302(1.01); C307(1.01); C498(1.20)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C225(1.10); C302(0.98); C307(0.91); C498(1.13)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C225(1.16); C302(1.15); C307(1.10); C498(1.07)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C225(1.04); C302(1.04); C307(0.90); C498(1.05)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C225(0.97); C302(0.91); C307(0.84); C498(1.45)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C225(1.09); C302(0.87); C307(0.82); C498(0.99)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C225(1.04); C302(1.01); C307(0.91); C498(0.97)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C225(1.15); C302(0.90); C307(0.88)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C225(1.08); C302(1.02); C307(0.89); C498(0.74)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C225(1.04); C302(0.83); C307(0.85); C498(1.00)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C225(1.09); C302(0.90); C307(0.97); C498(1.30)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C225(0.96); C302(0.87); C307(0.94); C498(1.40)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C225(1.01); C302(0.84); C307(0.94); C498(0.99)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C225(0.99); C302(0.92); C307(0.92); C498(1.17)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C225(1.12); C302(0.88); C307(0.89); C498(1.35)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C225(0.98); C302(0.92); C307(0.91); C498(1.00)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C225(1.38); C302(1.26); C307(1.48); C498(1.71)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C225(0.98); C302(0.94); C307(0.92); C498(1.45)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C225(1.31); C302(1.25); C307(1.35); C498(1.58)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C225(0.98); C302(1.06); C307(1.21); C498(1.61)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C225(1.19); C302(1.22); C307(1.32); C498(1.28)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C225(1.27); C302(1.27); C307(1.53); C498(1.20)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C225(1.42); C302(1.31); C307(1.49); C498(1.61)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C225(1.42); C302(1.19); C307(1.38); C498(1.55)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C225(1.24); C302(1.22); C307(1.32); C498(1.21)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C225(1.12); C302(1.20); C307(1.29); C498(1.18)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C225(1.53); C302(1.34); C307(1.56); C498(1.44)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C225(1.45); C302(1.50); C307(1.87); C498(1.58)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C225(1.22); C302(0.99); C307(0.98)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C225(1.76); C302(1.48); C307(1.71); C498(1.71)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C225(1.56); C302(1.52); C307(1.89); C498(1.40)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C225(1.07); C302(1.20); C307(1.33); C498(1.37)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C302(0.95); C307(0.98); C225(1.39)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C307(0.82); C302(0.82); C225(2.81)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C302(0.79); C307(0.85); C225(1.61)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C302(0.82); C307(0.91); C225(1.73)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C307(0.80); C302(0.82); C225(2.14)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C302(0.81); C307(0.90); C225(2.98)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C302(0.86); C307(0.94); C225(2.54)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C302(0.97); C307(0.98); C225(1.26)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C302(0.88); C307(0.93); C225(1.63)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C302(1.09); C307(1.19); C225(1.46)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C302(0.86); C307(0.96); C225(1.90)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C302(0.78); C307(0.89); C225(3.14)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C225(2.04); C302(0.82); C307(0.91)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C225(1.64); C302(0.93); C307(1.03)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C225(1.23); C302(0.88); C307(1.02)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C225(1.22); C302(0.77); C307(0.81)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C307(1.06); C302(1.06); C225(1.17)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C307(1.47); C302(1.50); C225(1.78)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C302(1.03); C307(1.08); C225(1.19)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C307(0.91); C302(0.92); C225(1.09)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C302(1.07); C307(1.10); C225(1.12)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C225(1.10); C302(1.18); C307(1.27)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C302(0.98); C225(0.99); C307(1.05)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C225(1.00); C302(1.11); C307(1.18)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C307(1.01); C302(1.02); C225(1.05)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C225(1.32); C302(1.43); C307(1.50)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C307(1.14); C302(1.16); C225(1.49)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C302(1.16); C307(1.19); C225(1.45)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C302(1.34); C307(1.37); C225(1.57)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C307(1.31); C302(1.35); C225(1.52)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C307(0.88); C302(0.90); C225(0.94)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C302(1.32); C307(1.37); C225(1.44)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C307(1.22); C302(1.24); C225(1.60)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C307(1.57); C302(1.63); C225(1.98)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C307(1.36); C302(1.40); C225(1.81)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C307(1.47); C302(1.50); C225(2.00)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C225(0.79); C302(1.06); C307(1.08)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C225(0.89); C302(1.15); C307(1.19)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C225(1.03); C302(1.10); C307(1.19)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C225(0.94); C302(1.06); C307(1.15)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C225(1.08); C302(1.11); C307(1.15)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C307(0.73); C302(0.88); C225(1.12)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C225(1.06); C302(1.29); C307(1.38)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C302(1.03); C307(1.09); C225(1.14)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C225(1.12); C302(1.21); C307(1.24)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C225(1.17); C302(1.20); C307(1.22)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C225(1.01); C302(1.29); C307(1.30)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C225(1.05); C302(1.30); C307(1.35)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C225(0.95); C302(1.01); C307(1.01)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C307(0.97); C302(0.98); C225(1.05)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C225(0.97); C307(0.99); C302(1.01)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C307(1.34); C225(1.35); C302(1.40)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C307(0.66); C302(0.87); C225(1.16)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C302(1.24); C307(1.28); C225(1.40)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C225(0.84); C302(0.91); C307(0.93)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C225(1.01); C307(1.02); C302(1.06)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C307(1.21); C302(1.25); C225(1.27)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C307(1.06); C302(1.12); C225(1.42)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C307(1.28); C302(1.30); C225(1.61)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C307(1.42); C302(1.43); C225(1.72)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C307(1.45); C302(1.49); C225(1.74)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C307(1.51); C302(1.55); C225(1.63)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C307(1.61); C302(1.62); C225(1.91)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C302(1.19); C307(1.19); C225(1.47)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C307(1.47); C302(1.52); C225(1.79)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C225(1.18); C307(1.54); C302(1.56)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C307(1.88); C225(1.90); C302(1.91)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C225(1.54); C302(1.63); C307(1.64)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C225(2.00); C307(2.10); C302(2.14)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C307(1.81); C302(1.87); C225(1.90)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C307(1.73); C302(1.76); C225(2.04)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C307(1.92); C302(1.92); C225(2.47)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C302(0.97); C307(0.97); C225(1.14)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C307(1.04); C302(1.06); C225(1.23)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C302(0.97); C307(0.99); C225(1.49)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C302(1.28); C225(1.33); C307(1.38)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C307(0.99); C302(1.09); C225(1.09)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C307(1.11); C302(1.14); C225(1.22)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C302(1.48); C307(1.55); C225(1.89)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C307(1.36); C302(1.37); C225(1.62)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C302(1.60); C307(1.68); C225(2.20)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C307(1.25); C302(1.29); C225(1.39)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C307(1.29); C302(1.30); C225(1.78)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C307(1.00); C302(1.04); C225(1.07)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C307(1.09); C302(1.15); C225(1.24)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C302(1.10); C307(1.12); C225(1.36)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C302(1.09); C225(1.10); C307(1.13)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C225(0.90); C302(0.94); C307(1.04)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C302(1.79); C225(1.96); C307(1.98)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C307(1.52); C302(1.59); C225(1.83)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C302(1.30); C307(1.31); C225(1.63)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C307(1.30); C302(1.44); C225(1.48)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C302(1.39); C307(1.39); C225(1.43)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C302(1.04); C307(1.14); C225(1.19)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C302(1.05); C307(1.06); C225(1.41)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C302(1.29); C307(1.41); C225(1.61)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C302(1.01); C307(1.03); C225(1.29)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C307(1.21); C302(1.26); C225(1.76)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C302(1.35); C307(1.46); C225(1.76)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C302(1.15); C307(1.18); C225(1.22)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C302(1.07); C307(1.13); C225(1.15)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C307(0.94); C302(0.99); C225(1.27)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C302(1.14); C225(1.19); C307(1.26)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C302(1.50); C307(1.68); C225(1.80)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C302(1.41); C307(1.45); C225(1.64)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C225(1.01); C302(1.11); C307(1.15)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C225(1.17); C302(0.99); C307(0.98)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C302(0.99); C307(0.99); C225(1.21)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C302(1.40); C307(1.41); C225(2.00)  LDD0592  [7]
 LDCM0020  ARS-1620 HCC44 C302(1.48); C307(1.48)  LDD0078  [7]
 LDCM0087  Capsaicin HEK-293T 8.22  LDD0185  [4]
 LDCM0632  CL-Sc Hep-G2 C608(0.53)  LDD2227  [10]
 LDCM0367  CL1 HCT 116 C498(0.86); C499(0.86); C500(0.86); C225(0.91)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C498(1.25); C499(1.25); C500(1.25); C225(1.27)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C307(0.98); C302(1.03); C225(1.03)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C225(1.38); C302(1.47); C307(1.48)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C225(1.05); C302(1.12); C307(1.13)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C302(1.16); C307(1.18); C225(1.21)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C302(1.01); C307(1.03); C225(1.23)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C225(1.23); C302(1.26); C307(1.33)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C302(1.50); C307(1.56); C225(1.79)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C302(1.41); C307(1.42); C225(1.81)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C307(1.55); C302(1.56); C225(1.81)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C302(1.35); C225(1.40); C307(1.47)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C498(0.60); C499(0.60); C500(0.60); C225(1.30)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C225(1.46); C302(1.69); C307(1.92)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C225(1.18); C302(1.54); C307(1.59)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C225(1.09); C302(1.22); C307(1.23)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C307(1.52); C302(1.52); C225(1.74)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C302(1.37); C225(1.39); C307(1.40)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C302(1.28); C307(1.30); C225(1.41)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C307(1.26); C302(1.27); C225(1.51)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C225(1.33); C302(1.48); C307(1.54)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C225(1.18); C302(1.23); C307(1.29)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C302(1.13); C307(1.19); C225(1.32)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C498(1.35); C499(1.35); C500(1.35); C307(1.61)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C302(1.12); C225(1.14); C307(1.21)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C225(0.85); C302(1.64); C307(2.01)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C225(1.13); C307(1.13); C302(1.21)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C225(1.41); C302(1.70); C307(1.74)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C225(1.32); C307(1.35); C302(1.40)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C225(1.06); C307(1.12); C302(1.20)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C225(1.18); C307(1.45); C302(1.49)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C225(1.22); C307(1.34); C302(1.38)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C225(1.55); C307(1.79); C302(1.81)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C498(1.04); C499(1.04); C500(1.04); C307(1.13)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C498(0.93); C499(0.93); C500(0.93); C225(1.20)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C498(0.95); C499(0.95); C500(0.95); C225(1.38)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C225(0.96); C302(1.27); C307(1.27)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C225(0.99); C302(1.36); C307(1.36)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C302(0.88); C307(0.88); C225(1.10)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C302(0.88); C307(0.88); C225(1.08)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C498(0.88); C499(0.88); C500(0.88); C225(0.99)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C302(1.34); C307(1.34); C225(1.41)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C302(1.24); C307(1.24); C225(1.49)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C302(1.41); C307(1.41); C225(2.20)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C302(1.18); C307(1.18); C225(1.35)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C302(1.24); C307(1.24); C225(1.36)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C225(1.48); C302(1.34); C307(1.34)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C225(1.26); C302(1.13); C307(1.13)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C225(1.37); C302(0.94); C307(0.94)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C225(1.33); C302(1.21); C307(1.21)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C225(1.61); C302(1.07); C307(1.07)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C225(0.95); C302(1.04); C307(1.06); C498(0.76)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C225(1.21); C302(1.00); C307(1.00)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C225(0.98); C302(1.08); C307(1.00); C498(0.91)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C225(1.10); C302(1.24); C307(1.07); C498(0.87)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C225(1.16); C302(1.68); C307(1.55); C498(1.18)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C225(1.42); C302(1.47); C307(1.39); C498(0.77)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C225(1.48); C302(1.27); C307(1.17); C498(0.80)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C225(1.29); C302(1.49); C307(1.42); C498(1.04)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C225(1.72); C302(1.12); C307(1.09); C498(0.86)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C225(1.35); C302(1.53); C307(1.36); C498(0.76)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C225(0.99); C302(1.44); C307(1.44); C498(0.80)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C225(1.35); C302(1.34); C307(1.13); C498(0.93)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C225(1.23); C302(1.39); C307(1.23); C498(1.06)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C225(1.98); C302(1.47); C307(1.42); C498(0.40)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C225(1.43); C302(1.28); C307(1.18); C498(0.60)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C225(1.45); C302(1.14); C307(1.11); C498(0.89)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C225(1.41); C302(1.25); C307(1.24); C498(0.80)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C225(0.85); C302(1.43); C307(1.43)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C225(0.88); C302(1.15); C307(1.15)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C225(0.94); C302(1.00); C307(1.00)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C225(1.08); C302(0.97); C307(0.97)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C225(1.20); C302(0.96); C307(0.95); C498(1.01)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C225(0.95); C302(0.88); C307(0.88)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C225(0.98); C302(1.06); C307(1.06)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C225(0.99); C302(1.48); C307(1.48)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C225(0.94); C302(0.95); C307(0.95)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C225(0.90); C302(1.04); C307(1.04)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C225(0.92); C302(1.22); C307(1.22)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C225(1.05); C302(0.84); C307(0.84)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C225(0.93); C302(0.92); C307(0.92)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C225(0.99); C302(1.42); C307(1.42)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C225(0.97); C302(0.93); C307(0.93)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C225(1.08); C302(1.16); C307(1.18); C498(0.88)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C225(0.96); C302(0.69); C307(0.69)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C225(1.27); C302(0.82); C307(0.82)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C225(1.33); C302(0.89); C307(0.89)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C225(1.48); C302(0.88); C307(0.88)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C225(1.35); C302(0.80); C307(0.80)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C225(1.12); C302(0.73); C307(0.73)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C225(1.51); C302(0.76); C307(0.76)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C225(1.42); C302(0.64); C307(0.64)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C225(1.37); C302(0.83); C307(0.83)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C225(1.11); C302(0.84); C307(0.84)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C225(1.33); C302(1.12); C307(1.12); C498(0.78)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C225(1.42); C302(0.83); C307(0.83)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C225(1.60); C302(0.86); C307(0.86)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C225(1.39); C302(0.86); C307(0.86)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C225(1.32); C302(0.81); C307(0.81)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C225(1.61); C302(0.79); C307(0.79)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C225(1.00); C302(1.06); C307(1.07)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C225(1.06); C302(0.82); C307(0.79)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C225(1.18); C302(1.01); C307(0.98)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C225(1.02); C302(0.86); C307(0.88)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C225(1.67); C302(1.94); C307(2.02); C498(0.66)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C225(1.04); C302(1.00); C307(1.00)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C225(0.94); C302(1.01); C307(0.94)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C225(1.02); C302(0.89); C307(0.91)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C225(0.81); C302(0.92); C307(0.91)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C225(0.99); C302(0.99); C307(0.99)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C225(0.95); C302(0.92); C307(0.90)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C225(0.98); C302(0.87); C307(0.89)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C225(0.99); C302(0.85); C307(0.83)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C225(0.99); C302(0.81); C307(0.80)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C225(1.03); C302(0.91); C307(0.91)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C225(1.24); C302(1.24); C307(1.25); C498(0.79)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C225(0.98); C302(0.95); C307(0.92)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C225(1.14); C302(0.94); C307(0.96)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C225(1.09); C302(1.06); C307(1.09)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C225(1.36); C302(0.92); C307(0.87)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C225(0.95); C302(1.03); C307(1.19)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C225(1.01); C302(0.95); C307(0.97)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C225(1.02); C302(0.82); C307(0.73)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C225(1.08); C302(0.88); C307(0.83)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C225(1.16); C302(1.10); C307(1.09)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C225(1.01); C302(1.06); C307(0.97)  LDD0811  [7]
 LDCM0028  Dobutamine HEK-293T 5.57  LDD0180  [4]
 LDCM0027  Dopamine HEK-293T 12.68  LDD0179  [4]
 LDCM0495  E2913 HEK-293T C225(0.89); C608(1.02)  LDD1698  [13]
 LDCM0031  Epigallocatechin gallate HEK-293T 25.35  LDD0183  [4]
 LDCM0468  Fragment33 HCT 116 C225(1.35); C302(0.90); C307(0.90)  LDD0785  [7]
 LDCM0427  Fragment51 HCT 116 C225(1.39); C302(1.36); C307(1.20); C498(0.44)  LDD0744  [7]
 LDCM0022  KB02 HCT 116 C302(4.66); C307(4.66); C225(4.28)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C302(4.02); C307(4.02); C225(3.22)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C302(6.53); C307(6.53); C225(5.82)  LDD0082  [7]
 LDCM0030  Luteolin HEK-293T 10.19  LDD0182  [4]
 LDCM0032  Oleacein HEK-293T 10.39  LDD0184  [4]
 LDCM0014  Panhematin HEK-293T 3.43  LDD0062  [6]
 LDCM0029  Quercetin HEK-293T 8.58  LDD0181  [4]
 LDCM0131  RA190 MM1.R C225(2.08)  LDD0304  [14]
 LDCM0003  Sulforaphane MCF-7 2.80  LDD0042  [3]
 LDCM0021  THZ1 HCT 116 C302(1.11); C307(1.11)  LDD2173  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase pellino homolog 1 (PELI1) Pellino family Q96FA3
E3 ubiquitin-protein ligase pellino homolog 2 (PELI2) Pellino family Q9HAT8
TNF receptor-associated factor 6 (TRAF6) TNF receptor-associated factor family Q9Y4K3
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) . Q13526
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Stimulator of interferon genes protein (STING1) STING family Q86WV6
Toll/interleukin-1 receptor domain-containing adapter protein (TIRAP) . P58753
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Interferon regulatory factor 4 (IRF4) IRF family Q15306
Interferon regulatory factor 7 (IRF7) IRF family Q92985
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Myeloid differentiation primary response protein MyD88 (MYD88) . Q99836

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Fostamatinib Small molecular drug DB12010
Investigative
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Irak-1/4 Inhibitor Small molecular drug D0I2FZ
Wo2012007375c1 Small molecular drug D04ZIV
Wo2012007375c7 Small molecular drug D0T2NE
Patented
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Indazoletriazolephenyl Derivative 1 Small molecular drug D0NT8U
Indazoletriazolephenyl Derivative 2 Small molecular drug D0O6GQ
Pyrazolopyrimidine And Thienopyrimidine Amide Derivative 1 Small molecular drug D0E5AT
Pyrazolopyrimidine And Thienopyrimidine Amide Derivative 2 Small molecular drug D0F2NW

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.
Mass spectrometry data entry: PXD006279
4 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.