Details of the Target

General Information of Target

Target ID LDTP00127
Target Name Nuclear envelope pore membrane protein POM 121C (POM121C)
Gene Name POM121C
Synonyms
Nuclear envelope pore membrane protein POM 121C; Nuclear pore membrane protein 121-2; POM121-2; Pore membrane protein of 121 kDa C
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSPAAAAAGAGERRRPIASVRDGRGRGCGGPAGAALLGLSLVGLLLYLVPAAAALAWLAV
GTTAAWWGLSREPRGSRPLSSFVQKARHRRTLFASPPAKSTANGNLLEPRTLLEGPDPAE
LLLMGSYLGKPGPPQPAPAPEGQDLRNRPGRRPPARPAPRSTPPSQPTHRVHHFYPSLPT
PLLRPSGRPSPRDRGTLPDRFVITPRRRYPIHQTQYSCPGVLPTVCWNGYHKKAVLSPRN
SRMVCSPVTVRIAPPDRRFSRSAIPEQIISSTLSSPSSNAPDPCAKETVLSALKEKKKKR
TVEEEDQIFLDGQENKRRRHDSSGSGHSAFEPLVASGVPASFVPKPGSLKRGLNSQSSDD
HLNKRSRSSSMSSLTGAYTSGIPSSSRNAITSSYSSTRGISQLWKRNGPSSSPFSSPASS
RSQTPERPAKKIREEELCHHSSSSTPLAADKESQGEKAADTTPRKKQNSNSQSTPGSSGQ
RKRKVQLLPSRRGEQLTLPPPPQLGYSITAEDLDLEKKASLQWFNQALEDKSDAASNSVT
ETPPTTQPSFTFTLPAAATASPPTSLLAPSTNPLLESLKKMQTPPSLPPCPESAGAATTE
ALSPPKTPSLLPPLGLSQSGPPGLLPSPSFDSKPPTTLLGLIPAPSMVPATDTKAPPTLQ
AETATKPQATSAPSPAPKQSFLFGTQNTSPSSPAAPAASSASPMFKPIFTAPPKSEKEGL
TPPGPSVSATAPSSSSLPTTTSTTAPTFQPVFSSMGPPASVPLPAPFFKQTTTPATAPTT
TAPLFTGLASATSAVAPITSASPSTDSASKPAFGFGINSVSSSSVSTTTSTATAASQPFL
FGAPQASAASFTPAMGSIFQFGKPPALPTTTTVTTFSQSLPTAVPTATSSSAADFSGFGS
TLATSAPATSSQPTLTFSNTSTPTFNIPFGSSAKSPLPSYPGANPQPAFGAAEGQPPGAA
KPALTPSFGSSFTFGNSAAPAPATAPTPAPASTIKIVPAHVPTPIQPTFGGATHSAFGLK
ATASAFGAPASSQPAFGGSTAVFSFGAATSSGFGATTQTASSGSSSSVFGSTTPSPFTFG
GSAAPAGSGSFGINVATPGSSATTGAFSFGAGQSGSTATSTPFTGGLGQNALGTTGQSTP
FAFNVGSTTESKPVFGGTATPTFGQNTPAPGVGTSGSSLSFGASSAPAQGFVGVGPFGSA
APSFSIGAGSKTPGARQRLQARRQHTRKK
Target Bioclass
Transporter and channel
Family
POM121 family
Subcellular location
Nucleus, nuclear pore complex
Function
Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL).
Uniprot ID
A8CG34
Ensemble ID
ENST00000607367.5
HGNC ID
HGNC:34005

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.23  LDD0402  [1]
HDSF-alk
 Probe Info  		2.39  LDD0197  [2]
DA-P2
 Probe Info  		4.61  LDD0348  [3]
CHEMBL5175495
 Probe Info  		6.42  LDD0196  [4]
TG42
 Probe Info  		9.01  LDD0326  [5]
DA-P3
 Probe Info  		4.99  LDD0181  [3]
AHL-Pu-1
 Probe Info  		C590(2.07)  LDD0168  [6]
DBIA
 Probe Info  		C284(1.17); C245(1.09)  LDD0078  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [8]
NAIA_5
 Probe Info  		C245(0.00); C268(0.00)  LDD2224  [9]
TFBX
 Probe Info  		N.A.  LDD0027  [10]
IPM
 Probe Info  		C438(0.00); C245(0.00)  LDD0005  [11]
Phosphinate-6
 Probe Info  		C438(0.00); C284(0.00)  LDD0018  [12]
W1
 Probe Info  		N.A.  LDD0236  [13]
AOyne
 Probe Info  		7.00  LDD0443  [14]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C251
 Probe Info  		39.95  LDD1924  [15]
C285
 Probe Info  		19.84  LDD1955  [15]
C289
 Probe Info  		30.70  LDD1959  [15]
C362
 Probe Info  		26.17  LDD2023  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C590(2.07)  LDD0168  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C590(2.50)  LDD0169  [6]
 LDCM0214  AC1 HEK-293T C438(1.05)  LDD1507  [16]
 LDCM0215  AC10 HEK-293T C438(1.02)  LDD1508  [16]
 LDCM0226  AC11 HEK-293T C438(0.99)  LDD1509  [16]
 LDCM0237  AC12 HEK-293T C438(1.12)  LDD1510  [16]
 LDCM0270  AC15 HEK-293T C438(1.02)  LDD1513  [16]
 LDCM0276  AC17 HEK-293T C438(1.09)  LDD1515  [16]
 LDCM0277  AC18 HEK-293T C438(1.05)  LDD1516  [16]
 LDCM0278  AC19 HEK-293T C438(0.95)  LDD1517  [16]
 LDCM0279  AC2 HEK-293T C438(0.89)  LDD1518  [16]
 LDCM0280  AC20 HEK-293T C438(1.16)  LDD1519  [16]
 LDCM0281  AC21 HEK-293T C438(1.16)  LDD1520  [16]
 LDCM0283  AC23 HEK-293T C438(0.85)  LDD1522  [16]
 LDCM0284  AC24 HEK-293T C438(0.85)  LDD1523  [16]
 LDCM0285  AC25 HEK-293T C438(1.01)  LDD1524  [16]
 LDCM0286  AC26 HEK-293T C438(0.95)  LDD1525  [16]
 LDCM0287  AC27 HEK-293T C438(0.95)  LDD1526  [16]
 LDCM0288  AC28 HEK-293T C438(1.05)  LDD1527  [16]
 LDCM0289  AC29 HEK-293T C438(1.14)  LDD1528  [16]
 LDCM0290  AC3 HEK-293T C438(0.96)  LDD1529  [16]
 LDCM0292  AC31 HEK-293T C438(0.91)  LDD1531  [16]
 LDCM0293  AC32 HEK-293T C438(0.94)  LDD1532  [16]
 LDCM0294  AC33 HEK-293T C438(1.17)  LDD1533  [16]
 LDCM0295  AC34 HEK-293T C438(1.04)  LDD1534  [16]
 LDCM0296  AC35 HEK-293T C438(1.12)  LDD1535  [16]
 LDCM0297  AC36 HEK-293T C438(1.06)  LDD1536  [16]
 LDCM0298  AC37 HEK-293T C438(1.06)  LDD1537  [16]
 LDCM0300  AC39 HEK-293T C438(1.04)  LDD1539  [16]
 LDCM0301  AC4 HEK-293T C438(1.03)  LDD1540  [16]
 LDCM0302  AC40 HEK-293T C438(0.98)  LDD1541  [16]
 LDCM0303  AC41 HEK-293T C438(1.02)  LDD1542  [16]
 LDCM0304  AC42 HEK-293T C438(1.14)  LDD1543  [16]
 LDCM0305  AC43 HEK-293T C438(0.99)  LDD1544  [16]
 LDCM0306  AC44 HEK-293T C438(1.12)  LDD1545  [16]
 LDCM0307  AC45 HEK-293T C438(0.88)  LDD1546  [16]
 LDCM0309  AC47 HEK-293T C438(1.01)  LDD1548  [16]
 LDCM0310  AC48 HEK-293T C438(0.88)  LDD1549  [16]
 LDCM0311  AC49 HEK-293T C438(0.98)  LDD1550  [16]
 LDCM0312  AC5 HEK-293T C438(1.24)  LDD1551  [16]
 LDCM0313  AC50 HEK-293T C438(0.95)  LDD1552  [16]
 LDCM0314  AC51 HEK-293T C438(0.95)  LDD1553  [16]
 LDCM0315  AC52 HEK-293T C438(0.99)  LDD1554  [16]
 LDCM0316  AC53 HEK-293T C438(0.94)  LDD1555  [16]
 LDCM0318  AC55 HEK-293T C438(0.79)  LDD1557  [16]
 LDCM0319  AC56 HEK-293T C438(0.91)  LDD1558  [16]
 LDCM0320  AC57 HEK-293T C438(0.93)  LDD1559  [16]
 LDCM0321  AC58 HEK-293T C438(0.92)  LDD1560  [16]
 LDCM0322  AC59 HEK-293T C438(0.98)  LDD1561  [16]
 LDCM0324  AC60 HEK-293T C438(1.00)  LDD1563  [16]
 LDCM0325  AC61 HEK-293T C438(0.80)  LDD1564  [16]
 LDCM0327  AC63 HEK-293T C438(1.13)  LDD1566  [16]
 LDCM0328  AC64 HEK-293T C438(0.81)  LDD1567  [16]
 LDCM0334  AC7 HEK-293T C438(1.01)  LDD1568  [16]
 LDCM0345  AC8 HEK-293T C438(0.94)  LDD1569  [16]
 LDCM0248  AKOS034007472 HEK-293T C438(1.06)  LDD1511  [16]
 LDCM0356  AKOS034007680 HEK-293T C438(1.17)  LDD1570  [16]
 LDCM0275  AKOS034007705 HEK-293T C438(0.96)  LDD1514  [16]
 LDCM0020  ARS-1620 HCC44 C284(1.17); C245(1.09)  LDD0078  [7]
 LDCM0102  BDHI 8 Jurkat C245(22.10)  LDD0204  [17]
 LDCM0087  Capsaicin HEK-293T 5.51  LDD0185  [3]
 LDCM0367  CL1 HEK-293T C438(0.91)  LDD1571  [16]
 LDCM0369  CL100 HEK-293T C438(0.90)  LDD1573  [16]
 LDCM0370  CL101 HEK-293T C438(0.89)  LDD1574  [16]
 LDCM0371  CL102 HEK-293T C438(0.96)  LDD1575  [16]
 LDCM0372  CL103 HEK-293T C438(1.04)  LDD1576  [16]
 LDCM0373  CL104 HEK-293T C438(0.91)  LDD1577  [16]
 LDCM0374  CL105 HEK-293T C438(0.98)  LDD1578  [16]
 LDCM0375  CL106 HEK-293T C438(0.92)  LDD1579  [16]
 LDCM0376  CL107 HEK-293T C438(1.00)  LDD1580  [16]
 LDCM0377  CL108 HEK-293T C438(0.96)  LDD1581  [16]
 LDCM0378  CL109 HEK-293T C438(0.97)  LDD1582  [16]
 LDCM0379  CL11 HEK-293T C438(1.00)  LDD1583  [16]
 LDCM0380  CL110 HEK-293T C438(0.93)  LDD1584  [16]
 LDCM0381  CL111 HEK-293T C438(1.06)  LDD1585  [16]
 LDCM0382  CL112 HEK-293T C438(1.07)  LDD1586  [16]
 LDCM0383  CL113 HEK-293T C438(1.04)  LDD1587  [16]
 LDCM0384  CL114 HEK-293T C438(1.08)  LDD1588  [16]
 LDCM0385  CL115 HEK-293T C438(1.03)  LDD1589  [16]
 LDCM0386  CL116 HEK-293T C438(1.00)  LDD1590  [16]
 LDCM0387  CL117 HEK-293T C438(0.94)  LDD1591  [16]
 LDCM0388  CL118 HEK-293T C438(0.96)  LDD1592  [16]
 LDCM0389  CL119 HEK-293T C438(1.10)  LDD1593  [16]
 LDCM0390  CL12 HEK-293T C438(0.82)  LDD1594  [16]
 LDCM0391  CL120 HEK-293T C438(0.90)  LDD1595  [16]
 LDCM0392  CL121 HEK-293T C438(0.94)  LDD1596  [16]
 LDCM0393  CL122 HEK-293T C438(0.84)  LDD1597  [16]
 LDCM0394  CL123 HEK-293T C438(0.95)  LDD1598  [16]
 LDCM0395  CL124 HEK-293T C438(0.73)  LDD1599  [16]
 LDCM0396  CL125 HEK-293T C438(0.64)  LDD1600  [16]
 LDCM0397  CL126 HEK-293T C438(0.75)  LDD1601  [16]
 LDCM0398  CL127 HEK-293T C438(0.85)  LDD1602  [16]
 LDCM0399  CL128 HEK-293T C438(0.66)  LDD1603  [16]
 LDCM0400  CL13 HEK-293T C438(0.89)  LDD1604  [16]
 LDCM0401  CL14 HEK-293T C438(1.07)  LDD1605  [16]
 LDCM0402  CL15 HEK-293T C438(0.88)  LDD1606  [16]
 LDCM0403  CL16 HEK-293T C438(0.89)  LDD1607  [16]
 LDCM0404  CL17 HEK-293T C438(1.06)  LDD1608  [16]
 LDCM0405  CL18 HEK-293T C438(1.09)  LDD1609  [16]
 LDCM0406  CL19 HEK-293T C438(1.14)  LDD1610  [16]
 LDCM0407  CL2 HEK-293T C438(1.05)  LDD1611  [16]
 LDCM0408  CL20 HEK-293T C438(1.08)  LDD1612  [16]
 LDCM0409  CL21 HEK-293T C438(0.89)  LDD1613  [16]
 LDCM0411  CL23 HEK-293T C438(1.07)  LDD1615  [16]
 LDCM0412  CL24 HEK-293T C438(0.90)  LDD1616  [16]
 LDCM0413  CL25 HEK-293T C438(0.77)  LDD1617  [16]
 LDCM0414  CL26 HEK-293T C438(1.04)  LDD1618  [16]
 LDCM0415  CL27 HEK-293T C438(0.94)  LDD1619  [16]
 LDCM0416  CL28 HEK-293T C438(1.05)  LDD1620  [16]
 LDCM0417  CL29 HEK-293T C438(1.00)  LDD1621  [16]
 LDCM0418  CL3 HEK-293T C438(0.95)  LDD1622  [16]
 LDCM0419  CL30 HEK-293T C438(0.87)  LDD1623  [16]
 LDCM0420  CL31 HEK-293T C438(0.90)  LDD1624  [16]
 LDCM0421  CL32 HEK-293T C438(0.95)  LDD1625  [16]
 LDCM0422  CL33 HEK-293T C438(0.72)  LDD1626  [16]
 LDCM0424  CL35 HEK-293T C438(0.83)  LDD1628  [16]
 LDCM0425  CL36 HEK-293T C438(0.92)  LDD1629  [16]
 LDCM0426  CL37 HEK-293T C438(0.83)  LDD1630  [16]
 LDCM0428  CL39 HEK-293T C438(1.18)  LDD1632  [16]
 LDCM0429  CL4 HEK-293T C438(0.97)  LDD1633  [16]
 LDCM0430  CL40 HEK-293T C438(1.29)  LDD1634  [16]
 LDCM0431  CL41 HEK-293T C438(1.13)  LDD1635  [16]
 LDCM0432  CL42 HEK-293T C438(0.96)  LDD1636  [16]
 LDCM0433  CL43 HEK-293T C438(0.96)  LDD1637  [16]
 LDCM0434  CL44 HEK-293T C438(1.11)  LDD1638  [16]
 LDCM0435  CL45 HEK-293T C438(1.04)  LDD1639  [16]
 LDCM0437  CL47 HEK-293T C438(0.86)  LDD1641  [16]
 LDCM0438  CL48 HEK-293T C438(0.91)  LDD1642  [16]
 LDCM0439  CL49 HEK-293T C438(0.77)  LDD1643  [16]
 LDCM0440  CL5 HEK-293T C438(0.95)  LDD1644  [16]
 LDCM0441  CL50 HEK-293T C438(0.99)  LDD1645  [16]
 LDCM0443  CL52 HEK-293T C438(1.22)  LDD1646  [16]
 LDCM0444  CL53 HEK-293T C438(1.05)  LDD1647  [16]
 LDCM0445  CL54 HEK-293T C438(0.83)  LDD1648  [16]
 LDCM0446  CL55 HEK-293T C438(1.07)  LDD1649  [16]
 LDCM0447  CL56 HEK-293T C438(1.11)  LDD1650  [16]
 LDCM0448  CL57 HEK-293T C438(1.09)  LDD1651  [16]
 LDCM0450  CL59 HEK-293T C438(0.75)  LDD1653  [16]
 LDCM0451  CL6 HEK-293T C438(0.84)  LDD1654  [16]
 LDCM0452  CL60 HEK-293T C438(0.83)  LDD1655  [16]
 LDCM0453  CL61 HEK-293T C438(0.81)  LDD1656  [16]
 LDCM0454  CL62 HEK-293T C438(1.06)  LDD1657  [16]
 LDCM0455  CL63 HEK-293T C438(1.01)  LDD1658  [16]
 LDCM0456  CL64 HEK-293T C438(0.89)  LDD1659  [16]
 LDCM0457  CL65 HEK-293T C438(1.10)  LDD1660  [16]
 LDCM0458  CL66 HEK-293T C438(1.08)  LDD1661  [16]
 LDCM0459  CL67 HEK-293T C438(1.07)  LDD1662  [16]
 LDCM0460  CL68 HEK-293T C438(1.14)  LDD1663  [16]
 LDCM0461  CL69 HEK-293T C438(1.02)  LDD1664  [16]
 LDCM0462  CL7 HEK-293T C438(0.93)  LDD1665  [16]
 LDCM0464  CL71 HEK-293T C438(0.90)  LDD1667  [16]
 LDCM0465  CL72 HEK-293T C438(0.85)  LDD1668  [16]
 LDCM0466  CL73 HEK-293T C438(0.83)  LDD1669  [16]
 LDCM0467  CL74 HEK-293T C438(0.84)  LDD1670  [16]
 LDCM0469  CL76 HEK-293T C438(1.00)  LDD1672  [16]
 LDCM0470  CL77 HEK-293T C438(1.05)  LDD1673  [16]
 LDCM0471  CL78 HEK-293T C438(0.97)  LDD1674  [16]
 LDCM0472  CL79 HEK-293T C438(0.89)  LDD1675  [16]
 LDCM0473  CL8 HEK-293T C438(0.78)  LDD1676  [16]
 LDCM0474  CL80 HEK-293T C438(1.05)  LDD1677  [16]
 LDCM0475  CL81 HEK-293T C438(0.85)  LDD1678  [16]
 LDCM0477  CL83 HEK-293T C438(1.02)  LDD1680  [16]
 LDCM0478  CL84 HEK-293T C438(0.83)  LDD1681  [16]
 LDCM0479  CL85 HEK-293T C438(0.64)  LDD1682  [16]
 LDCM0480  CL86 HEK-293T C438(0.50)  LDD1683  [16]
 LDCM0481  CL87 HEK-293T C438(0.84)  LDD1684  [16]
 LDCM0482  CL88 HEK-293T C438(0.67)  LDD1685  [16]
 LDCM0483  CL89 HEK-293T C438(0.83)  LDD1686  [16]
 LDCM0484  CL9 HEK-293T C438(1.09)  LDD1687  [16]
 LDCM0485  CL90 HEK-293T C438(0.79)  LDD1688  [16]
 LDCM0486  CL91 HEK-293T C438(0.80)  LDD1689  [16]
 LDCM0487  CL92 HEK-293T C438(0.87)  LDD1690  [16]
 LDCM0488  CL93 HEK-293T C438(0.94)  LDD1691  [16]
 LDCM0490  CL95 HEK-293T C438(1.02)  LDD1693  [16]
 LDCM0491  CL96 HEK-293T C438(0.45)  LDD1694  [16]
 LDCM0492  CL97 HEK-293T C438(0.97)  LDD1695  [16]
 LDCM0493  CL98 HEK-293T C438(1.06)  LDD1696  [16]
 LDCM0494  CL99 HEK-293T C438(1.02)  LDD1697  [16]
 LDCM0495  E2913 HEK-293T C438(1.12)  LDD1698  [16]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C245(1.48)  LDD1702  [18]
 LDCM0572  Fragment10 Ramos C284(1.32)  LDD2189  [19]
 LDCM0573  Fragment11 Ramos C284(3.14); C438(17.70)  LDD2190  [19]
 LDCM0574  Fragment12 Ramos C284(1.08)  LDD2191  [19]
 LDCM0575  Fragment13 Ramos C284(1.01)  LDD2192  [19]
 LDCM0576  Fragment14 Ramos C438(0.99)  LDD2193  [19]
 LDCM0579  Fragment20 Ramos C284(1.59)  LDD2194  [19]
 LDCM0580  Fragment21 Ramos C284(1.09)  LDD2195  [19]
 LDCM0582  Fragment23 Ramos C284(1.11)  LDD2196  [19]
 LDCM0578  Fragment27 Ramos C284(0.93)  LDD2197  [19]
 LDCM0586  Fragment28 Ramos C438(0.84)  LDD2198  [19]
 LDCM0588  Fragment30 Ramos C284(0.94)  LDD2199  [19]
 LDCM0589  Fragment31 Ramos C284(0.88)  LDD2200  [19]
 LDCM0590  Fragment32 Ramos C284(1.39)  LDD2201  [19]
 LDCM0468  Fragment33 HEK-293T C438(1.00)  LDD1671  [16]
 LDCM0596  Fragment38 Ramos C284(0.66)  LDD2203  [19]
 LDCM0566  Fragment4 Ramos C284(0.51); C438(2.25)  LDD2184  [19]
 LDCM0427  Fragment51 HEK-293T C438(1.25)  LDD1631  [16]
 LDCM0610  Fragment52 Ramos C284(0.75)  LDD2204  [19]
 LDCM0569  Fragment7 Ramos C284(1.41); C438(2.58)  LDD2186  [19]
 LDCM0571  Fragment9 Ramos C284(1.29)  LDD2188  [19]
 LDCM0022  KB02 HEK-293T C438(1.10)  LDD1492  [16]
 LDCM0023  KB03 HEK-293T C438(1.16)  LDD1497  [16]
 LDCM0024  KB05 COLO792 C3(3.48)  LDD3310  [20]
 LDCM0029  Quercetin HEK-293T 4.99  LDD0181  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Importin subunit beta-1 (KPNB1) Importin beta family Q14974

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Fatty Acyl Sulfonyl Fluoride as an Activity-Based Probe for Profiling Fatty Acid-Associated Proteins in Living Cells. Chembiochem. 2022 Feb 16;23(4):e202100628. doi: 10.1002/cbic.202100628. Epub 2021 Dec 30.
3 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
4 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
5 Design and synthesis of tailored human caseinolytic protease P inhibitors. Chem Commun (Camb). 2018 Aug 28;54(70):9833-9836. doi: 10.1039/c8cc05265d.
Mass spectrometry data entry: PXD010277
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
13 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
16 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
17 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
18 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
19 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
20 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840