Details of the Target

General Information of Target

Target ID LDTP00952
Target Name Germinal-center associated nuclear protein (MCM3AP)
Gene Name MCM3AP
Gene ID 8888
Synonyms
GANP; KIAA0572; MAP80; Germinal-center associated nuclear protein; GANP; EC 2.3.1.48; 80 kDa MCM3-associated protein; MCM3 acetylating protein; MCM3AP; EC 2.3.1.-; MCM3 acetyltransferase
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MNPTNPFSGQQPSAFSASSSNVGTLPSKPPFRFGQPSLFGQNSTLSGKSSGFSQVSSFPA
SSGVSHSSSVQTLGFTQTSSVGPFSGLEHTSTFVATSGPSSSSVLGNTGFSFKSPTSVGA
FPSTSAFGQEAGEIVNSGFGKTEFSFKPLENAVFKPILGAESEPEKTQSQIASGFFTFSH
PISSAPGGLAPFSFPQVTSSSATTSNFTFSKPVSSNNSLSAFTPALSNQNVEEEKRGPKS
IFGSSNNSFSSFPVSSAVLGEPFQASKAGVRQGCEEAVSQVEPLPSLMKGLKRKEDQDRS
PRRHGHEPAEDSDPLSRGDHPPDKRPVRLNRPRGGTLFGRTIQDVFKSNKEVGRLGNKEA
KKETGFVESAESDHMAIPGGNQSVLAPSRIPGVNKEEETESREKKEDSLRGTPARQSNRS
ESTDSLGGLSPSEVTAIQCKNIPDYLNDRTILENHFGKIAKVQRIFTRRSKKLAVVHFFD
HASAALARKKGKSLHKDMAIFWHRKKISPNKKPFSLKEKKPGDGEVSPSTEDAPFQHSPL
GKAAGRTGASSLLNKSSPVKKPSLLKAHQFEGDSFDSASEGSEGLGPCVLSLSTLIGTVA
ETSKEKYRLLDQRDRIMRQARVKRTDLDKARTFVGTCLDMCPEKERYMRETRSQLSVFEV
VPGTDQVDHAAAVKEYSRSSADQEEPLPHELRPLPVLSRTMDYLVTQIMDQKEGSLRDWY
DFVWNRTRGIRKDITQQHLCDPLTVSLIEKCTRFHIHCAHFMCEEPMSSFDAKINNENMT
KCLQSLKEMYQDLRNKGVFCASEAEFQGYNVLLSLNKGDILREVQQFHPAVRNSSEVKFA
VQAFAALNSNNFVRFFKLVQSASYLNACLLHCYFSQIRKDALRALNFAYTVSTQRSTIFP
LDGVVRMLLFRDCEEATDFLTCHGLTVSDGCVELNRSAFLEPEGLSKTRKSVFITRKLTV
SVGEIVNGGPLPPVPRHTPVCSFNSQNKYIGESLAAELPVSTQRPGSDTVGGGRGEECGV
EPDAPLSSLPQSLPAPAPSPVPLPPVLALTPSVAPSLFQLSVQPEPPPPEPVPMYSDEDL
AQVVDELIQEALQRDCEEVGSAGAAYAAAALGVSNAAMEDLLTAATTGILRHIAAEEVSK
ERERREQERQRAEEERLKQERELVLSELSQGLAVELMERVMMEFVRETCSQELKNAVETD
QRVRVARCCEDVCAHLVDLFLVEEIFQTAKETLQELQCFCKYLQRWREAVTARKKLRRQM
RAFPAAPCCVDVSDRLRALAPSAECPIAEENLARGLLDLGHAGRLGISCTRLRRLRNKTA
HQMKVQHFYQQLLSDVAWASLDLPSLVAEHLPGRQEHVFWKLVLVLPDVEEQSPESCGRI
LANWLKVKFMGDEGSVDDTSSDAGGIQTLSLFNSLSSKGDQMISVNVCIKVAHGALSDGA
IDAVETQKDLLGASGLMLLLPPKMKSEDMAEEDVYWLSALLQLKQLLQAKPFQPALPLVV
LVPSPGGDAVEKEVEDGLMLQDLVSAKLISDYTVTEIPDTINDLQGSTKVLQAVQWLVSH
CPHSLDLCCQTLIQYVEDGIGHEFSGRFFHDRRERRLGGLASQEPGAIIELFNSVLQFLA
SVVSSEQLCDLSWPVTEFAEAGGSRLLPHLHWNAPEHLAWLKQAVLGFQLPQMDLPPLGA
PWLPVCSMVVQYASQIPSSRQTQPVLQSQVENLLHRTYCRWKSKSPSPVHGAGPSVMEIP
WDDLIALCINHKLRDWTPPRLPVTSEALSEDGQICVYFFKNDLKKYDVPLSWEQARLQTQ
KELQLREGRLAIKPFHPSANNFPIPLLHMHRNWKRSTECAQEGRIPSTEDLMRGASAEEL
LAQCLSSSLLLEKEENKRFEDQLQQWLSEDSGAFTDLTSLPLYLPQTLVSLSHTIEPVMK
TSVTTSPQSDMMREQLQLSEATGTCLGERLKHLERLIRSSREEEVASELHLSALLDMVDI
Target Bioclass
Enzyme
Family
SAC3 family
Subcellular location
Cytoplasm; Nucleus envelope
Function
[Isoform GANP]: As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores. Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations.; [Isoform MCM3AP]: Binds to and acetylates the replication protein MCM3. Plays a role in the initiation of DNA replication and participates in controls that ensure that DNA replication initiates only once per cell cycle. Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations.
Uniprot ID
O60318
Ensemble ID
ENST00000291688.6
HGNC ID
HGNC:6946

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.Q1447P DBIA    Probe Info 
HCT116 SNV: p.E1021Ter DBIA    Probe Info 
HCT15 SNV: p.Q711H .
HEC1 SNV: p.C274Y DBIA    Probe Info 
HT115 SNV: p.N136S .
IGR1 SNV: p.R1760W DBIA    Probe Info 
IGROV1 Deletion: p.F1779LfsTer5 DBIA    Probe Info 
JEKO1 SNV: p.E1162A DBIA    Probe Info 
JM1 SNV: p.D373H DBIA    Probe Info 
KYSE150 SNV: p.S1564F DBIA    Probe Info 
NCIH2286 SNV: p.R449S DBIA    Probe Info 
NUGC3 SNV: p.R883W DBIA    Probe Info 
RH30 Deletion: p.I1129TfsTer26 DBIA    Probe Info 
RL952 SNV: p.P1648H DBIA    Probe Info 
SNGM SNV: p.P1036T DBIA    Probe Info 
T24 SNV: p.C1561R DBIA    Probe Info 
TOV21G SNV: p.P662Q DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.32  LDD0402  [1]
P8
 Probe Info  		1.64  LDD0455  [2]
DA-P3
 Probe Info  		12.04  LDD0185  [3]
AHL-Pu-1
 Probe Info  		C1864(3.57); C1839(2.42); C1309(3.16); C1285(2.89)  LDD0168  [4]
DBIA
 Probe Info  		C1268(1.35); C1269(1.35); C931(1.32); C1309(1.06)  LDD0078  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C981(0.00); C1839(0.00)  LDD0037  [6]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [7]
NAIA_4
 Probe Info  		N.A.  LDD2226  [8]
NAIA_5
 Probe Info  		C1945(0.00); C439(0.00)  LDD2224  [8]
TFBX
 Probe Info  		C439(0.00); C1377(0.00); C1285(0.00)  LDD0027  [7]
Compound 10
 Probe Info  		N.A.  LDD2216  [9]
ENE
 Probe Info  		C1839(0.00); C1285(0.00)  LDD0006  [10]
IPM
 Probe Info  		C981(0.00); C1285(0.00); C1240(0.00); C1945(0.00)  LDD0005  [10]
NPM
 Probe Info  		N.A.  LDD0016  [10]
VSF
 Probe Info  		C981(0.00); C1945(0.00)  LDD0007  [10]
Phosphinate-6
 Probe Info  		C641(0.00); C1839(0.00); C588(0.00); C274(0.00)  LDD0018  [11]
Acrolein
 Probe Info  		C1285(0.00); H1132(0.00)  LDD0217  [12]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [12]
Methacrolein
 Probe Info  		C1285(0.00); C1839(0.00); C1189(0.00); C1945(0.00)  LDD0218  [12]
AOyne
 Probe Info  		6.30  LDD0443  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C1864(3.57); C1839(2.42); C1309(3.16); C1285(2.89)  LDD0168  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C1864(2.89); C1285(2.21)  LDD0169  [4]
 LDCM0214  AC1 HCT 116 C1238(1.19); C1240(1.19); C1268(1.15); C1269(1.15)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C1238(1.13); C1240(1.15); C1268(1.10); C1269(1.10)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C1238(0.78); C1240(0.86); C1268(0.75); C1269(0.75)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C1238(0.82); C1240(0.88); C1268(0.89); C1269(0.89)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C1238(0.87); C1240(0.96); C1268(0.90); C1269(0.90)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C1238(0.91); C1240(0.94); C1268(1.10); C1269(1.10)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C1238(0.92); C1240(0.94); C1268(0.91); C1269(0.91)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C1238(0.89); C1240(0.96); C1268(0.81); C1269(0.81)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C1238(0.87); C1240(0.90); C1268(0.95); C1269(0.95)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C1238(0.89); C1240(0.89); C1268(1.00); C1269(1.00)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C1238(0.71); C1240(0.86); C1268(0.66); C1269(0.66)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C1238(0.76); C1240(0.87); C1268(0.72); C1269(0.72)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C1238(1.14); C1240(1.20); C1268(1.01); C1269(1.01)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C1238(0.77); C1240(0.92); C1268(0.78); C1269(0.78)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C1238(0.76); C1240(0.82); C1268(0.80); C1269(0.80)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C1238(0.80); C1240(0.89); C1268(0.91); C1269(0.91)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C1238(1.03); C1240(1.04); C1945(0.72); C637(0.80)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C1238(1.11); C1240(1.09); C1945(1.13); C637(0.94)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C1238(1.33); C1240(1.27); C1945(1.11); C637(1.34)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C1238(1.19); C1240(1.17); C1945(1.35); C637(0.86)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C1238(1.21); C1240(1.14); C1945(1.14); C637(0.99)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C1238(1.03); C1240(1.03); C1945(1.21); C637(1.03)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C1238(1.13); C1240(1.10); C1945(1.11); C637(1.03)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C1238(0.95); C1240(0.97); C1268(0.88); C1269(0.88)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C1238(1.17); C1240(1.13); C1945(1.01); C637(0.85)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C1238(1.09); C1240(1.03); C1945(1.58); C637(0.87)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C1238(1.11); C1240(1.12); C1945(1.05); C637(0.90)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C1238(1.34); C1240(1.20); C1945(1.22); C637(0.83)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C1238(1.28); C1240(1.22); C1945(0.92); C637(0.93)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C1238(1.01); C1240(1.00); C1945(1.08); C637(0.88)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C1238(1.11); C1240(1.04); C1945(1.19); C637(1.13)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C1238(1.07); C1240(1.05); C1945(1.01); C637(1.12)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C1268(0.88); C1269(0.88); C1945(1.30); C637(0.88)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C1268(0.88); C1269(0.88); C1945(0.95); C637(0.78)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C1268(0.84); C1269(0.84); C1945(0.99); C637(0.78)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C1268(0.64); C1269(0.64); C1945(1.09); C637(0.78)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C1268(0.87); C1269(0.87); C1945(1.08); C637(0.71)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C1268(0.94); C1269(0.94); C1945(1.09); C637(0.76)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C1268(0.88); C1269(0.88); C1945(1.38); C637(0.72)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C1268(1.18); C1269(1.18); C1945(1.27); C637(0.79)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C1268(0.79); C1269(0.79); C1945(1.13); C637(0.70)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C1268(0.69); C1269(0.69); C1945(1.06); C637(0.75)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C1268(0.83); C1269(0.83); C1945(1.54); C637(0.67)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C1268(0.77); C1269(0.77); C1945(1.35); C637(0.72)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C1238(1.24); C1240(1.27); C1268(1.07); C1269(1.07)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C1268(0.88); C1269(0.88); C1945(1.21); C637(0.70)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C1268(0.94); C1269(0.94); C1945(1.46); C637(0.66)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C1268(0.64); C1269(0.64); C1945(1.01); C637(0.70)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C637(0.80); C641(0.80); C1238(0.96); C1240(0.99)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C641(0.85); C637(0.97); C1238(1.02); C1240(1.05)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C641(0.77); C1238(0.93); C637(0.95); C1240(0.99)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C1240(0.99); C641(1.00); C1238(1.03); C637(1.08)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C641(0.83); C637(0.95); C1238(1.05); C931(1.12)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C641(0.70); C637(0.92); C1238(1.21); C1240(1.22)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C641(0.82); C637(0.98); C1240(0.99); C1238(1.11)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C637(0.84); C641(0.84); C1268(1.09); C1269(1.09)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C641(0.96); C1377(0.98); C637(0.99); C1240(1.01)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C641(0.93); C637(0.93); C1238(1.01); C1377(1.03)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C931(0.99); C637(1.00); C922(1.09); C641(1.16)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C641(0.72); C1240(1.03); C637(1.05); C1238(1.19)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C1238(1.15); C1240(1.12); C1268(1.00); C1269(1.09)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C1238(0.97); C1240(0.87); C1268(1.80); C1269(1.71)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C1238(0.96); C1240(0.76); C1268(1.28); C1269(1.24)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C1238(0.93); C1240(0.90); C1268(1.10); C1269(1.06)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C1268(0.73); C1269(0.73); C1839(0.77); C981(0.96)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C1268(0.51); C1269(0.51); C637(1.00); C641(1.00)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C1268(0.74); C1269(0.74); C981(0.97); C1240(0.99)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C931(0.73); C637(0.80); C641(0.80); C1839(0.83)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C1268(0.89); C1269(0.89); C1377(0.93); C1839(0.95)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C1268(0.73); C1269(0.73); C1839(0.92); C1377(1.03)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C1268(0.58); C1269(0.58); C1377(0.84); C1839(0.89)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C1268(0.65); C1269(0.65); C1377(0.84); C931(0.97)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C1268(0.60); C1269(0.60); C1377(0.71); C1839(0.80)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C1238(0.97); C1240(0.97); C981(0.99); C913(1.06)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C931(0.77); C913(0.81); C922(0.81); C1238(1.05)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C931(0.86); C981(1.03); C913(1.04); C922(1.04)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C913(0.83); C922(0.83); C931(0.84); C981(1.09)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C931(0.92); C913(0.96); C922(0.96); C981(0.98)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C637(0.78); C641(0.78); C1839(0.91); C1238(1.04)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C913(0.95); C922(0.95); C931(1.04); C981(1.10)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C931(0.97); C981(1.02); C1238(1.03); C913(1.13)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C931(1.10); C913(1.11); C922(1.11); C981(1.15)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C931(1.03); C1238(1.10); C913(1.10); C922(1.10)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C931(1.02); C913(1.09); C922(1.09); C1240(1.25)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C1240(0.77); C913(0.80); C922(0.80); C931(0.80)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C981(0.85); C1240(0.95); C1377(0.95); C1238(0.97)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C1240(0.71); C981(0.93); C913(0.96); C922(0.96)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C913(0.70); C922(0.70); C931(0.70); C1238(0.94)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C913(0.69); C922(0.69); C931(0.69); C1238(0.90)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C637(0.79); C641(0.79); C1839(0.92); C1238(1.07)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C1240(0.89); C1268(0.89); C1269(0.89); C1238(1.04)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C981(1.01); C1238(1.03); C1240(1.03); C913(1.09)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C913(1.02); C922(1.02); C931(1.02); C981(1.08)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C913(0.61); C922(0.61); C931(0.61); C1238(0.98)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C913(0.86); C922(0.86); C931(0.86); C1240(0.87)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C1240(0.88); C1268(0.94); C1269(0.94); C913(1.10)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C931(0.82); C1240(0.99); C1238(1.05); C981(1.06)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C931(0.47); C913(0.60); C922(0.60); C1240(0.82)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C931(0.76); C981(0.94); C913(0.97); C922(0.97)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C931(0.60); C1238(0.97); C913(0.98); C922(0.98)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C931(0.89); C1839(0.92); C637(0.96); C641(0.96)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C931(0.75); C913(0.93); C922(0.93); C1238(0.99)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C931(0.63); C913(0.76); C922(0.76); C1238(0.81)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C931(0.66); C913(0.85); C922(0.85); C1238(0.94)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C931(0.55); C913(0.68); C922(0.68); C1238(0.78)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C931(0.48); C913(0.64); C922(0.64); C1238(0.93)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C931(0.61); C913(0.74); C922(0.74); C1240(0.83)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C1238(0.85); C913(0.99); C922(0.99); C1240(1.07)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C637(0.71); C641(0.71); C1945(0.76); C1268(0.82)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C637(0.67); C641(0.67); C1268(0.68); C1269(0.68)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C1268(0.51); C1269(0.51); C637(0.70); C641(0.70)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C637(1.05); C641(1.05); C922(1.07); C1268(1.08)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C637(0.71); C641(0.71); C1268(0.75); C1269(0.75)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C1268(0.62); C1269(0.62); C637(0.68); C641(0.68)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C1268(0.65); C1269(0.65); C637(0.67); C641(0.67)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C1945(0.61); C1268(0.69); C1269(0.69); C637(0.75)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C1268(0.73); C1269(0.73); C637(0.76); C641(0.76)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C637(0.52); C641(0.52); C1268(0.57); C1269(0.57)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C637(0.49); C641(0.49); C1268(0.57); C1269(0.57)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C637(0.48); C641(0.48); C1268(0.62); C1269(0.62)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C922(0.89); C913(0.89); C931(0.90); C1377(0.99)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C1377(0.76); C931(1.12); C922(1.13); C913(1.13)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C637(0.92); C641(0.92); C1268(1.02); C1269(1.02)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C1377(0.62); C931(1.06); C913(1.12); C922(1.12)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C913(0.79); C922(0.79); C931(0.80); C1377(0.92)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C922(1.01); C931(1.04); C913(1.10); C1377(1.13)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C1377(1.15); C922(1.18); C913(1.21); C931(1.21)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C1377(1.10); C922(1.13); C913(1.17); C931(1.17)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C1377(1.02); C922(1.28); C913(1.29); C931(1.29)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C1377(1.00); C931(1.04); C913(1.05); C922(1.10)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C931(0.96); C922(1.01); C913(1.02); C1238(1.08)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C922(0.86); C1377(0.86); C913(0.87); C931(0.89)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C922(0.91); C931(0.91); C913(0.94); C1377(1.03)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C637(0.86); C641(0.86); C1268(0.92); C1269(0.92)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C931(0.98); C922(1.00); C913(1.03); C1377(1.03)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C1377(0.87); C931(1.02); C922(1.04); C913(1.04)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C1377(0.97); C931(1.23); C913(1.24); C922(1.27)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C931(0.88); C913(0.95); C922(0.95); C1240(0.95)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C931(0.87); C913(0.93); C922(0.93); C1240(1.00)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C931(0.92); C637(0.92); C641(0.92); C1240(0.93)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C913(0.99); C922(0.99); C637(1.00); C641(1.00)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C981(0.95); C637(0.99); C641(0.99); C931(0.99)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C913(0.93); C922(0.93); C931(0.94); C981(0.96)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C913(1.06); C922(1.06); C1238(1.07); C981(1.10)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C981(0.83); C637(0.92); C641(0.92); C1238(0.99)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C1238(0.94); C1240(0.96); C913(1.05); C922(1.05)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C913(0.89); C922(0.89); C931(0.91); C1240(0.92)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C1240(0.93); C1238(0.94); C931(0.97); C913(0.98)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C931(0.90); C913(0.96); C922(0.96); C637(1.08)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C1238(0.91); C913(0.97); C922(0.97); C1240(0.98)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C981(1.02); C1238(1.08); C637(1.10); C641(1.10)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C1238(0.96); C931(0.98); C913(1.00); C922(1.00)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C1377(0.71); C637(0.92); C641(0.92); C1839(0.95)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C913(0.58); C931(0.58); C637(0.68); C641(0.68)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C1238(1.12); C1240(1.15); C1268(0.94); C1269(0.94)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C637(0.90); C641(0.90); C1268(1.13); C1269(1.13)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C637(1.06); C641(1.06); C1268(1.24); C1269(1.24)  LDD0592  [5]
 LDCM0020  ARS-1620 HCC44 C1268(1.35); C1269(1.35); C931(1.32); C1309(1.06)  LDD0078  [5]
 LDCM0087  Capsaicin HEK-293T 12.04  LDD0185  [3]
 LDCM0108  Chloroacetamide HeLa C1839(0.00); C1945(0.00); H1132(0.00)  LDD0222  [12]
 LDCM0367  CL1 HCT 116 C913(0.85); C922(0.85); C981(0.87); C1238(0.90)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C1268(0.79); C1269(0.79); C1238(0.90); C1240(0.90)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C637(0.78); C641(0.78); C1839(0.98); C1268(0.99)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C637(0.85); C641(0.85); C1268(1.01); C1269(1.01)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C637(0.81); C641(0.81); C1268(0.83); C1269(0.83)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C637(0.92); C641(0.92); C1268(0.96); C1269(0.96)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C1268(0.93); C1269(0.93); C637(0.93); C641(0.93)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C1268(0.63); C1269(0.63); C1839(0.73); C637(0.96)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C1268(0.63); C1269(0.63); C637(1.09); C641(1.09)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C1268(0.72); C1269(0.72); C1839(1.00); C637(1.01)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C1268(0.72); C1269(0.72); C637(0.94); C641(0.94)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C1268(0.77); C1269(0.77); C637(1.02); C641(1.02)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C1268(0.97); C1269(0.97); C1238(0.99); C1240(0.99)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C1268(0.86); C1269(0.86); C637(1.06); C641(1.06)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C1268(0.70); C1269(0.70); C1377(0.87); C1839(1.05)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C931(0.97); C1238(1.05); C1240(1.07); C981(1.10)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C1238(1.15); C913(1.15); C922(1.15); C931(1.16)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C931(0.91); C913(0.93); C922(0.93); C981(0.96)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C931(0.83); C913(0.89); C922(0.89); C1238(1.05)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C913(0.93); C922(0.93); C931(0.96); C981(1.07)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C1238(1.05); C1377(1.12); C1240(1.15); C981(1.22)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C1238(1.00); C1268(1.02); C1269(1.02); C1240(1.06)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C913(0.70); C922(0.70); C931(0.70); C1238(0.93)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C1238(0.87); C1240(0.87); C1268(0.98); C1269(0.98)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C913(0.66); C922(0.66); C931(0.66); C1238(0.85)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C931(0.39); C913(0.79); C922(0.79); C981(0.93)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C931(0.50); C913(0.72); C922(0.72); C1240(0.98)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C931(0.75); C1240(1.10); C1238(1.12); C981(1.14)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C931(0.41); C913(0.85); C922(0.85); C1238(0.97)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C637(0.80); C641(0.80); C922(0.87); C981(0.91)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C637(0.72); C641(0.72); C922(0.77); C1945(0.85)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C1268(0.51); C1269(0.51); C637(0.72); C641(0.72)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C1268(0.62); C1269(0.62); C637(0.74); C641(0.74)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C1238(0.90); C1240(0.90); C1268(0.91); C1269(0.91)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C1238(0.85); C1240(0.85); C1268(0.87); C1269(0.87)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C1268(0.86); C1269(0.86); C1238(1.00); C1240(1.00)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C637(0.79); C641(0.79); C1268(0.90); C1269(0.90)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C981(0.80); C637(0.90); C641(0.90); C1240(0.92)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C981(0.86); C637(0.86); C641(0.86); C1268(1.04)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C981(0.88); C1268(0.92); C1269(0.92); C637(0.95)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C1238(0.83); C1240(0.83); C1268(0.86); C1269(0.86)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C637(0.85); C641(0.85); C981(0.90); C1268(0.96)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C981(0.82); C1268(0.96); C1269(0.96); C637(1.00)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C1268(0.84); C1269(0.84); C637(0.93); C641(0.93)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C1268(0.96); C1269(0.96); C981(0.98); C1240(0.98)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C981(0.91); C1268(0.97); C1269(0.97); C1240(1.07)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C1238(1.04); C1240(1.02); C1268(1.23); C1269(1.23)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C1238(1.13); C1240(1.15); C1268(1.02); C1269(1.02)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C1238(0.92); C1240(0.89); C1268(0.93); C1269(0.93)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C1238(0.98); C1240(0.98); C1268(1.01); C1269(1.01)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C1238(1.06); C1240(1.03); C1268(0.86); C1269(0.86)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C1238(0.81); C1240(0.81); C1268(0.74); C1269(0.74)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C1238(0.90); C1240(0.90); C1268(1.14); C1269(1.14)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C1238(1.14); C1240(1.14); C1268(1.31); C1269(1.31)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C1238(1.26); C1240(1.20); C1377(0.80); C637(0.95)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C1238(1.22); C1240(1.14); C1377(0.95); C637(0.83)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C1238(1.31); C1240(1.37); C1377(1.32); C637(0.93)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C1238(1.26); C1240(1.13); C1377(0.85); C637(0.83)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C1238(1.24); C1240(1.26); C1377(0.82); C637(0.91)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C1238(1.29); C1240(1.11); C1377(1.04); C637(0.99)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C1238(1.27); C1240(1.13); C1377(0.96); C637(0.87)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C1238(0.93); C1240(0.93); C1268(0.89); C1269(0.89)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C1238(1.40); C1240(1.14); C1377(0.96); C637(1.09)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C1238(1.25); C1240(1.23); C1377(0.92); C637(0.85)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C1238(1.67); C1240(1.65); C1377(1.45); C637(1.08)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C1238(1.28); C1240(1.23); C1377(0.96); C637(0.86)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C1238(1.27); C1240(1.11); C1377(1.17); C637(0.94)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C1238(1.36); C1240(1.09); C1377(0.95); C637(1.00)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C1238(0.84); C1240(0.86); C1268(1.07); C1269(1.07)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C1238(0.87); C1240(0.87); C1268(0.80); C1269(0.80)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C1238(0.83); C1240(0.82); C1268(0.86); C1269(0.86)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C1238(0.85); C1240(0.85); C1268(0.84); C1269(0.84)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C1238(0.91); C1240(0.91); C1268(1.01); C1269(1.01)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C1238(0.82); C1240(0.83); C1268(0.93); C1269(0.93)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C1238(0.84); C1240(0.87); C1268(0.91); C1269(0.91)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C1238(0.81); C1240(0.85); C1268(1.01); C1269(1.01)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C1238(0.92); C1240(0.89); C1268(0.82); C1269(0.82)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C1238(0.80); C1240(0.81); C1268(0.94); C1269(0.94)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C1238(0.78); C1240(0.79); C1268(0.99); C1269(0.99)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C1238(0.90); C1240(0.91); C1268(0.85); C1269(0.85)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C1238(0.89); C1240(0.89); C1268(0.89); C1269(0.89)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C1238(0.80); C1240(0.82); C1268(0.75); C1269(0.75)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C1238(0.87); C1240(0.89); C1268(0.94); C1269(0.94)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C1238(0.92); C1240(0.92); C1268(0.91); C1269(0.91)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C1238(0.90); C1240(0.89); C1268(0.91); C1269(0.91)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C1268(0.98); C1269(0.98); C1377(1.23); C637(1.04)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C1268(1.10); C1269(1.10); C1377(1.08); C637(1.07)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C1268(1.12); C1269(1.12); C1377(1.33); C637(1.06)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C1268(0.90); C1269(0.90); C1377(1.60); C637(1.01)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C1268(0.84); C1269(0.84); C1377(1.00); C637(0.99)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C1268(1.09); C1269(1.09); C1377(1.92); C637(1.02)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C1268(1.19); C1269(1.19); C1377(1.79); C637(0.97)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C1268(0.88); C1269(0.88); C1377(1.43); C637(1.03)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C1268(1.25); C1269(1.25); C1377(1.32); C637(1.33)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C1238(0.82); C1240(0.82); C1268(0.80); C1269(0.80)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C1268(1.15); C1269(1.15); C1377(1.53); C637(1.08)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C1268(0.95); C1269(0.95); C1377(1.32); C637(1.01)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C1268(1.13); C1269(1.13); C1377(1.19); C637(1.02)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C1268(1.17); C1269(1.17); C1377(1.41); C637(0.96)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C1268(0.91); C1269(0.91); C1377(1.62); C637(1.01)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C1238(1.12); C1240(1.06); C1268(0.93); C1269(0.93)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C1238(1.05); C1240(1.00); C1268(0.93); C1269(0.93)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C1238(1.24); C1240(1.03); C1268(0.99); C1269(0.99)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C1238(1.08); C1240(1.01); C1268(1.00); C1269(1.00)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C1238(1.70); C1240(1.70); C1268(1.30); C1269(1.30)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C1238(1.16); C1240(0.99); C1268(0.91); C1269(0.91)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C1238(0.97); C1240(0.97); C1268(1.01); C1269(1.01)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C1238(0.89); C1240(1.04); C1268(1.05); C1269(1.05)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C1238(1.19); C1240(1.03); C1268(1.13); C1269(1.13)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C1238(0.98); C1240(0.89); C1268(1.16); C1269(1.16)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C1238(1.02); C1240(0.94); C1268(0.95); C1269(0.95)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C1238(1.01); C1240(0.89); C1268(0.96); C1269(0.96)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C1238(0.98); C1240(0.98); C1268(1.01); C1269(1.01)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C1238(0.91); C1240(1.00); C1268(1.13); C1269(1.13)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C1238(1.00); C1240(0.97); C1268(1.00); C1269(1.00)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C1238(0.96); C1240(0.96); C1268(0.98); C1269(0.98)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C1238(1.05); C1240(0.99); C1268(1.01); C1269(1.01)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C1238(1.09); C1240(1.09); C1268(1.22); C1269(1.22)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C1238(1.04); C1240(1.04); C1268(0.97); C1269(0.97)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C1238(1.01); C1240(1.01); C1268(1.12); C1269(1.12)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C1238(1.08); C1240(1.08); C1268(1.17); C1269(1.17)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C1238(1.25); C1240(1.25); C1268(0.88); C1269(0.88)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C1238(1.13); C1240(1.13); C1268(0.87); C1269(0.87)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C1238(1.04); C1240(1.04); C1268(0.97); C1269(0.97)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C1238(1.22); C1240(1.22); C1268(1.38); C1269(1.38)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C1238(1.23); C1240(1.23); C1268(1.18); C1269(1.18)  LDD0811  [5]
 LDCM0634  CY-0357 Hep-G2 C1285(0.53)  LDD2228  [8]
 LDCM0495  E2913 HEK-293T C981(0.98); C1309(1.04); C1945(1.16); C1285(0.94)  LDD1698  [14]
 LDCM0625  F8 Ramos C1839(1.25); C1945(2.00)  LDD2187  [15]
 LDCM0572  Fragment10 Ramos C1839(3.05)  LDD2189  [15]
 LDCM0573  Fragment11 Ramos C1839(2.84)  LDD2190  [15]
 LDCM0574  Fragment12 Ramos C1839(2.13)  LDD2191  [15]
 LDCM0575  Fragment13 Ramos C1839(1.05); C1945(1.69)  LDD2192  [15]
 LDCM0576  Fragment14 Ramos C1839(0.40)  LDD2193  [15]
 LDCM0579  Fragment20 Ramos C1839(5.13)  LDD2194  [15]
 LDCM0580  Fragment21 Ramos C1839(1.23); C1945(1.31)  LDD2195  [15]
 LDCM0582  Fragment23 Ramos C1839(0.80); C1945(0.87)  LDD2196  [15]
 LDCM0578  Fragment27 Ramos C1839(0.99); C1945(1.29)  LDD2197  [15]
 LDCM0586  Fragment28 Ramos C1839(0.68); C1945(0.86)  LDD2198  [15]
 LDCM0588  Fragment30 Ramos C1839(1.64)  LDD2199  [15]
 LDCM0589  Fragment31 Ramos C1839(1.00)  LDD2200  [15]
 LDCM0590  Fragment32 Ramos C1839(3.65)  LDD2201  [15]
 LDCM0468  Fragment33 HCT 116 C1268(0.93); C1269(0.93); C1377(1.21); C637(0.97)  LDD0785  [5]
 LDCM0596  Fragment38 Ramos C1839(1.07); C1945(1.54)  LDD2203  [15]
 LDCM0566  Fragment4 Ramos C1839(1.56)  LDD2184  [15]
 LDCM0427  Fragment51 HCT 116 C1238(1.49); C1240(1.19); C1377(1.10); C637(0.94)  LDD0744  [5]
 LDCM0610  Fragment52 Ramos C1839(1.54)  LDD2204  [15]
 LDCM0614  Fragment56 Ramos C1839(1.55); C1945(1.10)  LDD2205  [15]
 LDCM0569  Fragment7 Ramos C1839(2.25)  LDD2186  [15]
 LDCM0571  Fragment9 Ramos C1839(3.55)  LDD2188  [15]
 LDCM0107  IAA HeLa N.A.  LDD0221  [12]
 LDCM0022  KB02 HCT 116 C1268(7.84); C1269(7.84); C1377(2.11)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C1268(11.53); C1269(11.53); C1377(3.00)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C1268(7.62); C1269(7.62); C1377(2.41)  LDD0082  [5]
 LDCM0109  NEM HeLa N.A.  LDD0223  [12]
 LDCM0021  THZ1 HCT 116 C1268(0.94); C1269(0.94); C1238(1.10); C1240(1.10)  LDD2173  [5]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
3 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578