Details of the Target

General Information of Target

Target ID LDTP07152
Target Name Acyl-CoA-binding domain-containing protein 5 (ACBD5)
Gene Name ACBD5
Gene ID 91452
Synonyms
KIAA1996; Acyl-CoA-binding domain-containing protein 5
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MFQFHAGSWESWCCCCLIPADRPWDRGQHWQLEMADTRSVHETRFEAAVKVIQSLPKNGS
FQPTNEMMLKFYSFYKQATEGPCKLSRPGFWDPIGRYKWDAWSSLGDMTKEEAMIAYVEE
MKKIIETMPMTEKVEELLRVIGPFYEIVEDKKSGRSSDITSVRLEKISKCLEDLGNVLTS
TPNAKTVNGKAESSDSGAESEEEEAQEEVKGAEQSDNDKKMMKKSADHKNLEVIVTNGYD
KDGFVQDIQNDIHASSSLNGRSTEEVKPIDENLGQTGKSAVCIHQDINDDHVEDVTGIQH
LTSDSDSEVYCDSMEQFGQEESLDSFTSNNGPFQYYLGGHSSQPMENSGFREDIQVPPGN
GNIGNMQVVAVEGKGEVKHGGEDGRNNSGAPHREKRGGETDEFSNVRRGRGHRMQHLSEG
TKGRQVGSGGDGERWGSDRGSRGSLNEQIALVLMRLQEDMQNVLQRLQKLETLTALQAKS
STSTLQTAPQPTSQRPSWWPFEMSPGVLTFAIIWPFIAQWLVYLYYQRRRRKLN
Target Bioclass
Transporter and channel
Family
ATG37 family
Subcellular location
Peroxisome membrane
Function Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters.
Uniprot ID
Q5T8D3
Ensemble ID
ENST00000375888.5
HGNC ID
HGNC:23338

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K422(6.67); K469(10.00)  LDD0277  [2]
BTD
 Probe Info  		C83(0.52)  LDD2089  [3]
DA-P3
 Probe Info  		11.87  LDD0179  [4]
EA-probe
 Probe Info  		N.A.  LDD0440  [5]
DBIA
 Probe Info  		C83(1.13)  LDD0532  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [7]
WYneO
 Probe Info  		N.A.  LDD0022  [8]
IPM
 Probe Info  		N.A.  LDD0147  [9]
TFBX
 Probe Info  		N.A.  LDD0148  [9]
AOyne
 Probe Info  		13.70  LDD0443  [10]
PAL-AfBPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C092
 Probe Info  		19.29  LDD1783  [11]
C231
 Probe Info  		16.45  LDD1904  [11]
C232
 Probe Info  		35.02  LDD1905  [11]
C235
 Probe Info  		21.11  LDD1908  [11]
C278
 Probe Info  		53.82  LDD1948  [11]
C289
 Probe Info  		42.81  LDD1959  [11]
C343
 Probe Info  		12.38  LDD2005  [11]
C350
 Probe Info  		24.25  LDD2011  [11]
C403
 Probe Info  		14.72  LDD2061  [11]
C407
 Probe Info  		18.00  LDD2064  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C83(0.22)  LDD1093  [6]
 LDCM0215  AC10 HCT 116 C83(1.13)  LDD0532  [6]
 LDCM0216  AC100 HEK-293T C83(0.78)  LDD0814  [6]
 LDCM0217  AC101 HEK-293T C83(0.80)  LDD0815  [6]
 LDCM0218  AC102 HEK-293T C83(0.63)  LDD0816  [6]
 LDCM0219  AC103 HEK-293T C83(0.60)  LDD0817  [6]
 LDCM0220  AC104 HEK-293T C83(0.69)  LDD0818  [6]
 LDCM0221  AC105 HEK-293T C83(1.21)  LDD0819  [6]
 LDCM0222  AC106 HEK-293T C83(1.01)  LDD0820  [6]
 LDCM0223  AC107 HEK-293T C83(1.03)  LDD0821  [6]
 LDCM0224  AC108 HEK-293T C83(1.07)  LDD0822  [6]
 LDCM0225  AC109 HEK-293T C83(0.88)  LDD0823  [6]
 LDCM0226  AC11 HCT 116 C83(0.91)  LDD0543  [6]
 LDCM0227  AC110 HEK-293T C83(0.61)  LDD0825  [6]
 LDCM0228  AC111 HEK-293T C83(0.81)  LDD0826  [6]
 LDCM0229  AC112 HEK-293T C83(0.60)  LDD0827  [6]
 LDCM0230  AC113 PaTu 8988t C83(0.53)  LDD1109  [6]
 LDCM0231  AC114 PaTu 8988t C83(1.18)  LDD1110  [6]
 LDCM0232  AC115 PaTu 8988t C83(0.45)  LDD1111  [6]
 LDCM0233  AC116 PaTu 8988t C83(0.53)  LDD1112  [6]
 LDCM0234  AC117 PaTu 8988t C83(0.84)  LDD1113  [6]
 LDCM0235  AC118 PaTu 8988t C83(1.05)  LDD1114  [6]
 LDCM0236  AC119 PaTu 8988t C83(0.48)  LDD1115  [6]
 LDCM0237  AC12 HCT 116 C83(1.33)  LDD0554  [6]
 LDCM0238  AC120 PaTu 8988t C83(0.86)  LDD1117  [6]
 LDCM0239  AC121 PaTu 8988t C83(0.50)  LDD1118  [6]
 LDCM0240  AC122 PaTu 8988t C83(1.45)  LDD1119  [6]
 LDCM0241  AC123 PaTu 8988t C83(0.88)  LDD1120  [6]
 LDCM0242  AC124 PaTu 8988t C83(0.45)  LDD1121  [6]
 LDCM0243  AC125 PaTu 8988t C83(0.92)  LDD1122  [6]
 LDCM0244  AC126 PaTu 8988t C83(1.20)  LDD1123  [6]
 LDCM0245  AC127 PaTu 8988t C83(0.54)  LDD1124  [6]
 LDCM0246  AC128 HEK-293T C83(0.89)  LDD0844  [6]
 LDCM0247  AC129 HEK-293T C83(0.46)  LDD0845  [6]
 LDCM0249  AC130 HEK-293T C83(0.68)  LDD0847  [6]
 LDCM0250  AC131 HEK-293T C83(0.91)  LDD0848  [6]
 LDCM0251  AC132 HEK-293T C83(0.73)  LDD0849  [6]
 LDCM0252  AC133 HEK-293T C83(0.52)  LDD0850  [6]
 LDCM0253  AC134 HEK-293T C83(0.42)  LDD0851  [6]
 LDCM0254  AC135 HEK-293T C83(0.66)  LDD0852  [6]
 LDCM0255  AC136 HEK-293T C83(0.54)  LDD0853  [6]
 LDCM0256  AC137 HEK-293T C83(0.51)  LDD0854  [6]
 LDCM0257  AC138 HEK-293T C83(0.42)  LDD0855  [6]
 LDCM0258  AC139 HEK-293T C83(0.41)  LDD0856  [6]
 LDCM0259  AC14 HCT 116 C83(0.90)  LDD0576  [6]
 LDCM0260  AC140 HEK-293T C83(0.55)  LDD0858  [6]
 LDCM0261  AC141 HEK-293T C83(0.52)  LDD0859  [6]
 LDCM0262  AC142 HEK-293T C83(0.47)  LDD0860  [6]
 LDCM0263  AC143 PaTu 8988t C83(0.64)  LDD1142  [6]
 LDCM0264  AC144 PaTu 8988t C83(0.67)  LDD1143  [6]
 LDCM0265  AC145 PaTu 8988t C83(0.72)  LDD1144  [6]
 LDCM0266  AC146 PaTu 8988t C83(0.81)  LDD1145  [6]
 LDCM0267  AC147 PaTu 8988t C83(0.81)  LDD1146  [6]
 LDCM0268  AC148 PaTu 8988t C83(0.79)  LDD1147  [6]
 LDCM0269  AC149 PaTu 8988t C83(0.73)  LDD1148  [6]
 LDCM0270  AC15 HCT 116 C83(1.23)  LDD0587  [6]
 LDCM0271  AC150 PaTu 8988t C83(0.70)  LDD1150  [6]
 LDCM0272  AC151 PaTu 8988t C83(0.85)  LDD1151  [6]
 LDCM0273  AC152 PaTu 8988t C83(0.62)  LDD1152  [6]
 LDCM0274  AC153 PaTu 8988t C83(0.66)  LDD1153  [6]
 LDCM0621  AC154 PaTu 8988t C83(0.70)  LDD2166  [6]
 LDCM0622  AC155 PaTu 8988t C83(0.85)  LDD2167  [6]
 LDCM0623  AC156 PaTu 8988t C83(0.67)  LDD2168  [6]
 LDCM0624  AC157 PaTu 8988t C83(0.98)  LDD2169  [6]
 LDCM0276  AC17 HCT 116 C83(1.45)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C83(3.18)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C83(1.11)  LDD0595  [6]
 LDCM0279  AC2 PaTu 8988t C83(0.24)  LDD1158  [6]
 LDCM0280  AC20 HCT 116 C83(1.11)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C83(0.80)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C83(1.91)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C83(1.60)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C83(2.01)  LDD0601  [6]
 LDCM0285  AC25 HEK-293T C83(1.10); C170(1.21)  LDD1524  [12]
 LDCM0286  AC26 HEK-293T C83(1.00); C170(0.95)  LDD1525  [12]
 LDCM0287  AC27 HEK-293T C83(0.98); C170(1.03)  LDD1526  [12]
 LDCM0288  AC28 HEK-293T C83(0.98); C170(0.76)  LDD1527  [12]
 LDCM0289  AC29 HEK-293T C83(1.01)  LDD1528  [12]
 LDCM0290  AC3 PaTu 8988t C83(0.39)  LDD1169  [6]
 LDCM0291  AC30 HEK-293T C83(0.99); C170(1.38)  LDD1530  [12]
 LDCM0292  AC31 HEK-293T C83(1.05); C170(1.19)  LDD1531  [12]
 LDCM0293  AC32 HEK-293T C83(1.01); C170(0.95)  LDD1532  [12]
 LDCM0294  AC33 HEK-293T C83(0.95); C170(1.15)  LDD1533  [12]
 LDCM0295  AC34 HEK-293T C83(0.94); C170(1.00)  LDD1534  [12]
 LDCM0296  AC35 HEK-293T C83(1.81)  LDD0894  [6]
 LDCM0297  AC36 HEK-293T C83(1.69)  LDD0895  [6]
 LDCM0298  AC37 HEK-293T C83(1.19)  LDD0896  [6]
 LDCM0299  AC38 HEK-293T C83(1.62)  LDD0897  [6]
 LDCM0300  AC39 HEK-293T C83(1.24)  LDD0898  [6]
 LDCM0301  AC4 PaTu 8988t C83(0.56)  LDD1180  [6]
 LDCM0302  AC40 HEK-293T C83(1.17)  LDD0900  [6]
 LDCM0303  AC41 HEK-293T C83(1.47)  LDD0901  [6]
 LDCM0304  AC42 HEK-293T C83(1.14)  LDD0902  [6]
 LDCM0305  AC43 HEK-293T C83(1.30)  LDD0903  [6]
 LDCM0306  AC44 HEK-293T C83(1.00)  LDD0904  [6]
 LDCM0307  AC45 HEK-293T C83(1.21)  LDD0905  [6]
 LDCM0308  AC46 HEK-293T C83(1.17)  LDD0906  [6]
 LDCM0309  AC47 HEK-293T C83(1.08)  LDD0907  [6]
 LDCM0310  AC48 HEK-293T C83(0.86)  LDD0908  [6]
 LDCM0311  AC49 HEK-293T C83(0.78)  LDD0909  [6]
 LDCM0312  AC5 PaTu 8988t C83(0.28)  LDD1191  [6]
 LDCM0313  AC50 HEK-293T C83(0.78)  LDD0911  [6]
 LDCM0314  AC51 HEK-293T C83(0.62)  LDD0912  [6]
 LDCM0315  AC52 HEK-293T C83(0.66)  LDD0913  [6]
 LDCM0316  AC53 HEK-293T C83(1.00)  LDD0914  [6]
 LDCM0317  AC54 HEK-293T C83(0.65)  LDD0915  [6]
 LDCM0318  AC55 HEK-293T C83(0.76)  LDD0916  [6]
 LDCM0319  AC56 HEK-293T C83(0.90)  LDD0917  [6]
 LDCM0320  AC57 HCT 116 C83(0.44)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C83(0.52)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C83(0.46)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C83(0.39)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C83(0.63)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C83(0.86)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C83(0.42)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C83(0.49)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C83(0.45)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C83(0.56)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C83(0.57)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C83(0.43)  LDD0648  [6]
 LDCM0334  AC7 HCT 116 C83(1.48)  LDD0651  [6]
 LDCM0345  AC8 HCT 116 C83(0.47)  LDD0662  [6]
 LDCM0349  AC83 HCT 116 C83(0.36)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C83(0.36)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C83(0.79)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C83(0.45)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C83(1.62)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C83(0.63)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C83(0.35)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C83(1.22)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C83(0.38)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C83(0.41)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C83(0.49)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C83(0.62)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C83(1.94)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C83(0.50)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C83(0.40)  LDD0681  [6]
 LDCM0365  AC98 HEK-293T C83(0.88)  LDD0963  [6]
 LDCM0366  AC99 HEK-293T C83(1.18)  LDD0964  [6]
 LDCM0248  AKOS034007472 HCT 116 C83(3.19)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C83(0.83)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C83(0.65)  LDD0592  [6]
 LDCM0156  Aniline NCI-H1299 12.98  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C83(0.52)  LDD2091  [3]
 LDCM0087  Capsaicin HEK-293T 7.21  LDD0185  [4]
 LDCM0367  CL1 PaTu 8988t C83(1.37)  LDD1246  [6]
 LDCM0368  CL10 PaTu 8988t C83(1.30)  LDD1247  [6]
 LDCM0369  CL100 PaTu 8988t C83(0.49)  LDD1248  [6]
 LDCM0370  CL101 HCT 116 C83(0.46)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C83(0.94)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C83(0.93)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C83(1.05)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C83(1.03)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C83(0.83)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C83(0.72)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C83(0.85)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C83(0.94)  LDD0695  [6]
 LDCM0379  CL11 PaTu 8988t C83(1.30)  LDD1258  [6]
 LDCM0380  CL110 HCT 116 C83(0.61)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C83(1.42)  LDD0698  [6]
 LDCM0382  CL112 HEK-293T C83(1.07); C170(1.32)  LDD1586  [12]
 LDCM0383  CL113 HEK-293T C83(0.95); C170(1.14)  LDD1587  [12]
 LDCM0384  CL114 HEK-293T C83(1.43); C170(0.97)  LDD1588  [12]
 LDCM0385  CL115 HEK-293T C83(0.84); C170(0.81)  LDD1589  [12]
 LDCM0386  CL116 HEK-293T C83(0.90); C170(1.03)  LDD1590  [12]
 LDCM0387  CL117 HEK-293T C83(1.23)  LDD0985  [6]
 LDCM0388  CL118 HEK-293T C83(2.11)  LDD0986  [6]
 LDCM0389  CL119 HEK-293T C83(1.16)  LDD0987  [6]
 LDCM0390  CL12 PaTu 8988t C83(1.35)  LDD1269  [6]
 LDCM0391  CL120 HEK-293T C83(1.12)  LDD0989  [6]
 LDCM0392  CL121 HEK-293T C83(0.75)  LDD0990  [6]
 LDCM0393  CL122 HEK-293T C83(0.76)  LDD0991  [6]
 LDCM0394  CL123 HEK-293T C83(0.83)  LDD0992  [6]
 LDCM0395  CL124 HEK-293T C83(0.67)  LDD0993  [6]
 LDCM0396  CL125 HCT 116 C83(0.66)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C83(1.09)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C83(0.54)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C83(0.46)  LDD0716  [6]
 LDCM0400  CL13 PaTu 8988t C83(1.16)  LDD1279  [6]
 LDCM0401  CL14 PaTu 8988t C83(1.17)  LDD1280  [6]
 LDCM0402  CL15 PaTu 8988t C83(0.98)  LDD1281  [6]
 LDCM0403  CL16 HEK-293T C83(0.93)  LDD1001  [6]
 LDCM0404  CL17 HEK-293T C83(1.25)  LDD1002  [6]
 LDCM0405  CL18 HEK-293T C83(0.85)  LDD1003  [6]
 LDCM0406  CL19 HEK-293T C83(0.82)  LDD1004  [6]
 LDCM0407  CL2 PaTu 8988t C83(1.03)  LDD1286  [6]
 LDCM0408  CL20 HEK-293T C83(1.08)  LDD1006  [6]
 LDCM0409  CL21 HEK-293T C83(1.21)  LDD1007  [6]
 LDCM0410  CL22 HEK-293T C83(0.83)  LDD1008  [6]
 LDCM0411  CL23 HEK-293T C83(1.60)  LDD1009  [6]
 LDCM0412  CL24 HEK-293T C83(1.42)  LDD1010  [6]
 LDCM0413  CL25 HEK-293T C83(1.07)  LDD1011  [6]
 LDCM0414  CL26 HEK-293T C83(1.25)  LDD1012  [6]
 LDCM0415  CL27 HEK-293T C83(1.12)  LDD1013  [6]
 LDCM0416  CL28 HEK-293T C83(1.10)  LDD1014  [6]
 LDCM0417  CL29 HEK-293T C83(1.10)  LDD1015  [6]
 LDCM0418  CL3 PaTu 8988t C83(1.10)  LDD1297  [6]
 LDCM0419  CL30 HEK-293T C83(0.69)  LDD1017  [6]
 LDCM0420  CL31 HEK-293T C83(0.71)  LDD1018  [6]
 LDCM0421  CL32 HEK-293T C83(0.74)  LDD1019  [6]
 LDCM0422  CL33 HEK-293T C83(0.73)  LDD1020  [6]
 LDCM0423  CL34 HEK-293T C83(0.81)  LDD1021  [6]
 LDCM0424  CL35 HEK-293T C83(0.75)  LDD1022  [6]
 LDCM0425  CL36 HEK-293T C83(0.97)  LDD1023  [6]
 LDCM0426  CL37 HEK-293T C83(0.68)  LDD1024  [6]
 LDCM0428  CL39 HEK-293T C83(0.39)  LDD1026  [6]
 LDCM0429  CL4 PaTu 8988t C83(1.68)  LDD1308  [6]
 LDCM0430  CL40 HEK-293T C83(0.51)  LDD1028  [6]
 LDCM0431  CL41 HEK-293T C83(0.39)  LDD1029  [6]
 LDCM0432  CL42 HEK-293T C83(0.36)  LDD1030  [6]
 LDCM0433  CL43 HEK-293T C83(0.42)  LDD1031  [6]
 LDCM0434  CL44 HEK-293T C83(0.59)  LDD1032  [6]
 LDCM0435  CL45 HEK-293T C83(0.45)  LDD1033  [6]
 LDCM0436  CL46 HEK-293T C83(0.40)  LDD1034  [6]
 LDCM0437  CL47 HEK-293T C83(0.55)  LDD1035  [6]
 LDCM0438  CL48 HEK-293T C83(0.50)  LDD1036  [6]
 LDCM0439  CL49 HEK-293T C83(0.51)  LDD1037  [6]
 LDCM0440  CL5 PaTu 8988t C83(1.43)  LDD1319  [6]
 LDCM0441  CL50 HEK-293T C83(0.40)  LDD1039  [6]
 LDCM0442  CL51 HEK-293T C83(0.56)  LDD1040  [6]
 LDCM0443  CL52 HEK-293T C83(1.04)  LDD1041  [6]
 LDCM0444  CL53 HEK-293T C83(0.73)  LDD1042  [6]
 LDCM0445  CL54 HEK-293T C83(0.67)  LDD1043  [6]
 LDCM0446  CL55 HEK-293T C83(0.40)  LDD1044  [6]
 LDCM0447  CL56 HEK-293T C83(0.70)  LDD1045  [6]
 LDCM0448  CL57 HEK-293T C83(0.59)  LDD1046  [6]
 LDCM0449  CL58 HEK-293T C83(0.58)  LDD1047  [6]
 LDCM0450  CL59 HEK-293T C83(0.44)  LDD1048  [6]
 LDCM0451  CL6 PaTu 8988t C83(1.16)  LDD1330  [6]
 LDCM0452  CL60 HEK-293T C83(0.40)  LDD1050  [6]
 LDCM0453  CL61 HCT 116 C83(1.13)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C83(1.66)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C83(0.75)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C83(0.59)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C83(1.22)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C83(0.80)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C83(0.76)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C83(0.95)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C83(1.14)  LDD0778  [6]
 LDCM0462  CL7 PaTu 8988t C83(1.05)  LDD1341  [6]
 LDCM0463  CL70 HCT 116 C83(1.36)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C83(0.86)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C83(0.91)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C83(0.72)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C83(0.99)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C83(1.17)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C83(1.92)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C83(0.63)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C83(0.55)  LDD0789  [6]
 LDCM0473  CL8 PaTu 8988t C83(0.95)  LDD1352  [6]
 LDCM0474  CL80 HCT 116 C83(1.04)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C83(0.90)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C83(0.58)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C83(0.49)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C83(0.50)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C83(0.92)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C83(1.33)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C83(0.85)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C83(1.03)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C83(0.84)  LDD0800  [6]
 LDCM0484  CL9 PaTu 8988t C83(1.83)  LDD1363  [6]
 LDCM0485  CL90 HCT 116 C83(1.44)  LDD0802  [6]
 LDCM0486  CL91 PaTu 8988t C83(0.66)  LDD1365  [6]
 LDCM0487  CL92 PaTu 8988t C83(0.40)  LDD1366  [6]
 LDCM0488  CL93 PaTu 8988t C83(0.29)  LDD1367  [6]
 LDCM0489  CL94 PaTu 8988t C83(0.26)  LDD1368  [6]
 LDCM0490  CL95 PaTu 8988t C83(0.21)  LDD1369  [6]
 LDCM0491  CL96 PaTu 8988t C83(0.34)  LDD1370  [6]
 LDCM0492  CL97 PaTu 8988t C83(0.50)  LDD1371  [6]
 LDCM0493  CL98 PaTu 8988t C83(0.35)  LDD1372  [6]
 LDCM0494  CL99 PaTu 8988t C83(0.42)  LDD1373  [6]
 LDCM0027  Dopamine HEK-293T 11.87  LDD0179  [4]
 LDCM0495  E2913 HEK-293T C83(0.88); C170(0.93)  LDD1698  [12]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [5]
 LDCM0468  Fragment33 HCT 116 C83(1.39)  LDD0785  [6]
 LDCM0427  Fragment51 HEK-293T C83(0.94)  LDD1025  [6]
 LDCM0015  HNE MDA-MB-231 C83(1.21)  LDD0346  [13]
 LDCM0022  KB02 HEK-293T C83(0.70)  LDD1492  [12]
 LDCM0023  KB03 HEK-293T C83(0.71)  LDD1497  [12]
 LDCM0024  KB05 IGR37 C85(2.07)  LDD3314  [14]
 LDCM0030  Luteolin HEK-293T 7.80  LDD0182  [4]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C83(0.42)  LDD2121  [3]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C83(0.52)  LDD2089  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C83(0.94)  LDD2125  [3]
 LDCM0029  Quercetin HEK-293T 8.59  LDD0181  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sodium-coupled neutral amino acid transporter 7 (SLC38A7) Amino acid/polyamine transporter 2 family Q9NVC3
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Metabotropic glutamate receptor 2 (GRM2) G-protein coupled receptor 3 family Q14416
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Syntaxin-1B (STX1B) Syntaxin family P61266
Transmembrane protein 229B (TMEM229B) TMEM229 family Q8NBD8

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
5 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
14 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840