Details of the Target

General Information of Target

Target ID LDTP04597
Target Name Methylosome subunit pICln (CLNS1A)
Gene Name CLNS1A
Gene ID 1207
Synonyms
CLCI; ICLN; Methylosome subunit pICln; Chloride channel, nucleotide sensitive 1A; Chloride conductance regulatory protein ICln; I(Cln); Chloride ion current inducer protein; ClCI; Reticulocyte pICln
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSFLKSFPPPGPAEGLLRQQPDTEAVLNGKGLGTGTLYIAESRLSWLDGSGLGFSLEYPT
ISLHALSRDRSDCLGEHLYVMVNAKFEEESKEPVADEEEEDSDDDVEPITEFRFVPSDKS
ALEAMFTAMCECQALHPDPEDEDSDDYDGEEYDVEAHEQGQGDIPTFYTYEEGLSHLTAE
GQATLERLEGMLSQSVSSQYNMAGVRTEDSIRDYEDGMEVDTTPTVAGQFEDADVDH
Target Bioclass
Transporter and channel
Family
PICln (TC 1.A.47) family
Subcellular location
Cytoplasm, cytosol
Function
Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins. Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.
Uniprot ID
P54105
Ensemble ID
ENST00000525428.6
HGNC ID
HGNC:2080

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 25 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
FBP2
 Probe Info  		3.71  LDD0323  [2]
TH211
 Probe Info  		Y38(6.32)  LDD0257  [3]
BTD
 Probe Info  		C73(0.97)  LDD2092  [4]
AHL-Pu-1
 Probe Info  		C73(10.72)  LDD0168  [5]
HHS-475
 Probe Info  		Y200(1.04)  LDD0264  [6]
HHS-465
 Probe Info  		Y200(8.90)  LDD2237  [7]
Acrolein
 Probe Info  		N.A.  LDD0223  [8]
DBIA
 Probe Info  		C73(1.29)  LDD0080  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [10]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [11]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [12]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [10]
NAIA_4
 Probe Info  		N.A.  LDD2226  [13]
DA-P3
 Probe Info  		N.A.  LDD0178  [14]
Compound 10
 Probe Info  		N.A.  LDD2216  [15]
Compound 11
 Probe Info  		N.A.  LDD2213  [15]
IPM
 Probe Info  		N.A.  LDD0005  [16]
SF
 Probe Info  		N.A.  LDD0028  [17]
TFBX
 Probe Info  		N.A.  LDD0148  [18]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [19]
1c-yne
 Probe Info  		K30(0.00); K5(0.00)  LDD0228  [20]
W1
 Probe Info  		N.A.  LDD0236  [21]
AOyne
 Probe Info  		14.70  LDD0443  [22]
NAIA_5
 Probe Info  		N.A.  LDD2223  [13]
PAL-AfBPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C285
 Probe Info  		24.59  LDD1955  [23]
C286
 Probe Info  		5.13  LDD1956  [23]
C287
 Probe Info  		15.14  LDD1957  [23]
C288
 Probe Info  		7.26  LDD1958  [23]
C289
 Probe Info  		45.89  LDD1959  [23]
C296
 Probe Info  		12.55  LDD1966  [23]
C310
 Probe Info  		8.34  LDD1977  [23]
C322
 Probe Info  		7.94  LDD1988  [23]
C338
 Probe Info  		11.39  LDD2001  [23]
C413
 Probe Info  		12.38  LDD2069  [23]
FFF probe11
 Probe Info  		5.61  LDD0472  [24]
FFF probe13
 Probe Info  		9.13  LDD0476  [24]
FFF probe2
 Probe Info  		15.72  LDD0463  [24]
FFF probe3
 Probe Info  		9.44  LDD0464  [24]
VE-P
 Probe Info  		N.A.  LDD0396  [25]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C73(10.72)  LDD0168  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C73(3.38)  LDD0169  [5]
 LDCM0214  AC1 HCT 116 C73(1.06)  LDD0531  [9]
 LDCM0215  AC10 HCT 116 C73(0.61)  LDD0532  [9]
 LDCM0216  AC100 HEK-293T C73(1.03)  LDD0814  [9]
 LDCM0217  AC101 HEK-293T C73(0.96)  LDD0815  [9]
 LDCM0218  AC102 HEK-293T C73(1.03)  LDD0816  [9]
 LDCM0219  AC103 HEK-293T C73(0.87)  LDD0817  [9]
 LDCM0220  AC104 HEK-293T C73(0.89)  LDD0818  [9]
 LDCM0221  AC105 HEK-293T C73(0.96)  LDD0819  [9]
 LDCM0222  AC106 HEK-293T C73(0.84)  LDD0820  [9]
 LDCM0223  AC107 HEK-293T C73(0.95)  LDD0821  [9]
 LDCM0224  AC108 HEK-293T C73(0.96)  LDD0822  [9]
 LDCM0225  AC109 HEK-293T C73(0.97)  LDD0823  [9]
 LDCM0226  AC11 HCT 116 C73(0.55)  LDD0543  [9]
 LDCM0227  AC110 HEK-293T C73(0.92)  LDD0825  [9]
 LDCM0228  AC111 HEK-293T C73(1.09)  LDD0826  [9]
 LDCM0229  AC112 HEK-293T C73(1.00)  LDD0827  [9]
 LDCM0237  AC12 HCT 116 C73(0.69)  LDD0554  [9]
 LDCM0246  AC128 HEK-293T C73(1.33)  LDD0844  [9]
 LDCM0247  AC129 HEK-293T C73(1.37)  LDD0845  [9]
 LDCM0249  AC130 HEK-293T C73(1.65)  LDD0847  [9]
 LDCM0250  AC131 HEK-293T C73(1.09)  LDD0848  [9]
 LDCM0251  AC132 HEK-293T C73(1.50)  LDD0849  [9]
 LDCM0252  AC133 HEK-293T C73(1.11)  LDD0850  [9]
 LDCM0253  AC134 HEK-293T C73(1.11)  LDD0851  [9]
 LDCM0254  AC135 HEK-293T C73(1.06)  LDD0852  [9]
 LDCM0255  AC136 HEK-293T C73(0.84)  LDD0853  [9]
 LDCM0256  AC137 HEK-293T C73(1.26)  LDD0854  [9]
 LDCM0257  AC138 HEK-293T C73(1.31)  LDD0855  [9]
 LDCM0258  AC139 HEK-293T C73(1.39)  LDD0856  [9]
 LDCM0259  AC14 HCT 116 C73(1.11)  LDD0576  [9]
 LDCM0260  AC140 HEK-293T C73(1.18)  LDD0858  [9]
 LDCM0261  AC141 HEK-293T C73(1.20)  LDD0859  [9]
 LDCM0262  AC142 HEK-293T C73(1.16)  LDD0860  [9]
 LDCM0263  AC143 PaTu 8988t C73(1.16)  LDD1142  [9]
 LDCM0264  AC144 PaTu 8988t C73(1.06)  LDD1143  [9]
 LDCM0265  AC145 PaTu 8988t C73(1.16)  LDD1144  [9]
 LDCM0266  AC146 PaTu 8988t C73(1.50)  LDD1145  [9]
 LDCM0267  AC147 PaTu 8988t C73(1.35)  LDD1146  [9]
 LDCM0268  AC148 PaTu 8988t C73(1.38)  LDD1147  [9]
 LDCM0269  AC149 PaTu 8988t C73(1.24)  LDD1148  [9]
 LDCM0270  AC15 HCT 116 C73(1.20)  LDD0587  [9]
 LDCM0271  AC150 PaTu 8988t C73(1.53)  LDD1150  [9]
 LDCM0272  AC151 PaTu 8988t C73(1.94)  LDD1151  [9]
 LDCM0273  AC152 PaTu 8988t C73(1.25)  LDD1152  [9]
 LDCM0274  AC153 PaTu 8988t C73(1.97)  LDD1153  [9]
 LDCM0621  AC154 PaTu 8988t C73(1.70)  LDD2166  [9]
 LDCM0622  AC155 PaTu 8988t C73(1.52)  LDD2167  [9]
 LDCM0623  AC156 PaTu 8988t C73(1.35)  LDD2168  [9]
 LDCM0624  AC157 PaTu 8988t C73(1.54)  LDD2169  [9]
 LDCM0276  AC17 HCT 116 C73(0.97)  LDD0593  [9]
 LDCM0277  AC18 HCT 116 C73(0.97)  LDD0594  [9]
 LDCM0278  AC19 HCT 116 C73(0.88)  LDD0595  [9]
 LDCM0279  AC2 HCT 116 C73(1.13)  LDD0596  [9]
 LDCM0280  AC20 HCT 116 C73(1.23)  LDD0597  [9]
 LDCM0281  AC21 HCT 116 C73(0.91)  LDD0598  [9]
 LDCM0282  AC22 HCT 116 C73(1.22)  LDD0599  [9]
 LDCM0283  AC23 HCT 116 C73(1.07)  LDD0600  [9]
 LDCM0284  AC24 HCT 116 C73(1.20)  LDD0601  [9]
 LDCM0285  AC25 PaTu 8988t C73(0.91)  LDD1164  [9]
 LDCM0286  AC26 PaTu 8988t C73(1.02)  LDD1165  [9]
 LDCM0287  AC27 PaTu 8988t C73(1.15)  LDD1166  [9]
 LDCM0288  AC28 PaTu 8988t C73(1.42)  LDD1167  [9]
 LDCM0289  AC29 PaTu 8988t C73(1.08)  LDD1168  [9]
 LDCM0290  AC3 HCT 116 C73(1.01)  LDD0607  [9]
 LDCM0291  AC30 PaTu 8988t C73(1.01)  LDD1170  [9]
 LDCM0292  AC31 PaTu 8988t C73(0.84)  LDD1171  [9]
 LDCM0293  AC32 PaTu 8988t C73(0.92)  LDD1172  [9]
 LDCM0294  AC33 PaTu 8988t C73(1.37)  LDD1173  [9]
 LDCM0295  AC34 PaTu 8988t C73(0.96)  LDD1174  [9]
 LDCM0296  AC35 HCT 116 C73(0.99)  LDD0613  [9]
 LDCM0297  AC36 HCT 116 C73(0.96)  LDD0614  [9]
 LDCM0298  AC37 HCT 116 C73(1.05)  LDD0615  [9]
 LDCM0299  AC38 HCT 116 C73(1.06)  LDD0616  [9]
 LDCM0300  AC39 HCT 116 C73(0.86)  LDD0617  [9]
 LDCM0301  AC4 HCT 116 C73(1.08)  LDD0618  [9]
 LDCM0302  AC40 HCT 116 C73(0.91)  LDD0619  [9]
 LDCM0303  AC41 HCT 116 C73(0.87)  LDD0620  [9]
 LDCM0304  AC42 HCT 116 C73(1.00)  LDD0621  [9]
 LDCM0305  AC43 HCT 116 C73(0.89)  LDD0622  [9]
 LDCM0306  AC44 HCT 116 C73(0.83)  LDD0623  [9]
 LDCM0307  AC45 HCT 116 C73(0.83)  LDD0624  [9]
 LDCM0308  AC46 HCT 116 C73(1.04)  LDD0625  [9]
 LDCM0309  AC47 HCT 116 C73(0.97)  LDD0626  [9]
 LDCM0310  AC48 HCT 116 C73(1.22)  LDD0627  [9]
 LDCM0311  AC49 HCT 116 C73(1.73)  LDD0628  [9]
 LDCM0312  AC5 HCT 116 C73(1.01)  LDD0629  [9]
 LDCM0313  AC50 HCT 116 C73(1.28)  LDD0630  [9]
 LDCM0314  AC51 HCT 116 C73(1.44)  LDD0631  [9]
 LDCM0315  AC52 HCT 116 C73(1.36)  LDD0632  [9]
 LDCM0316  AC53 HCT 116 C73(1.14)  LDD0633  [9]
 LDCM0317  AC54 HCT 116 C73(1.25)  LDD0634  [9]
 LDCM0318  AC55 HCT 116 C73(0.90)  LDD0635  [9]
 LDCM0319  AC56 HCT 116 C73(1.37)  LDD0636  [9]
 LDCM0320  AC57 HEK-293T C73(1.03)  LDD1559  [26]
 LDCM0321  AC58 HEK-293T C73(0.98)  LDD1560  [26]
 LDCM0322  AC59 HEK-293T C73(1.01)  LDD1561  [26]
 LDCM0323  AC6 HCT 116 C73(0.91)  LDD0640  [9]
 LDCM0324  AC60 HEK-293T C73(1.00)  LDD1563  [26]
 LDCM0325  AC61 HEK-293T C73(1.01)  LDD1564  [26]
 LDCM0326  AC62 HEK-293T C73(0.96)  LDD1565  [26]
 LDCM0327  AC63 HEK-293T C73(0.97)  LDD1566  [26]
 LDCM0328  AC64 HEK-293T C73(1.00)  LDD1567  [26]
 LDCM0332  AC68 HCT 116 C73(0.81)  LDD0649  [9]
 LDCM0333  AC69 HCT 116 C73(0.90)  LDD0650  [9]
 LDCM0334  AC7 HCT 116 C73(0.72)  LDD0651  [9]
 LDCM0335  AC70 HCT 116 C73(0.91)  LDD0652  [9]
 LDCM0336  AC71 HCT 116 C73(0.85)  LDD0653  [9]
 LDCM0337  AC72 HCT 116 C73(1.02)  LDD0654  [9]
 LDCM0338  AC73 HCT 116 C73(0.95)  LDD0655  [9]
 LDCM0339  AC74 HCT 116 C73(0.85)  LDD0656  [9]
 LDCM0340  AC75 HCT 116 C73(0.95)  LDD0657  [9]
 LDCM0341  AC76 HCT 116 C73(0.87)  LDD0658  [9]
 LDCM0342  AC77 HCT 116 C73(0.96)  LDD0659  [9]
 LDCM0343  AC78 HCT 116 C73(0.93)  LDD0660  [9]
 LDCM0344  AC79 HCT 116 C73(0.97)  LDD0661  [9]
 LDCM0345  AC8 HCT 116 C73(1.01)  LDD0662  [9]
 LDCM0346  AC80 HCT 116 C73(0.82)  LDD0663  [9]
 LDCM0347  AC81 HCT 116 C73(0.85)  LDD0664  [9]
 LDCM0348  AC82 HCT 116 C73(0.84)  LDD0665  [9]
 LDCM0349  AC83 HCT 116 C73(1.20)  LDD0666  [9]
 LDCM0350  AC84 HCT 116 C73(1.16)  LDD0667  [9]
 LDCM0351  AC85 HCT 116 C73(1.21)  LDD0668  [9]
 LDCM0352  AC86 HCT 116 C73(1.37)  LDD0669  [9]
 LDCM0353  AC87 HCT 116 C73(1.02)  LDD0670  [9]
 LDCM0354  AC88 HCT 116 C73(1.02)  LDD0671  [9]
 LDCM0355  AC89 HCT 116 C73(1.21)  LDD0672  [9]
 LDCM0357  AC90 HCT 116 C73(0.96)  LDD0674  [9]
 LDCM0358  AC91 HCT 116 C73(1.20)  LDD0675  [9]
 LDCM0359  AC92 HCT 116 C73(0.99)  LDD0676  [9]
 LDCM0360  AC93 HCT 116 C73(0.89)  LDD0677  [9]
 LDCM0361  AC94 HCT 116 C73(1.10)  LDD0678  [9]
 LDCM0362  AC95 HCT 116 C73(1.05)  LDD0679  [9]
 LDCM0363  AC96 HCT 116 C73(1.00)  LDD0680  [9]
 LDCM0364  AC97 HCT 116 C73(1.08)  LDD0681  [9]
 LDCM0365  AC98 HEK-293T C73(0.93)  LDD0963  [9]
 LDCM0366  AC99 HEK-293T C73(0.97)  LDD0964  [9]
 LDCM0248  AKOS034007472 HCT 116 C73(0.78)  LDD0565  [9]
 LDCM0356  AKOS034007680 HCT 116 C73(0.70)  LDD0673  [9]
 LDCM0275  AKOS034007705 HCT 116 C73(0.97)  LDD0592  [9]
 LDCM0156  Aniline NCI-H1299 12.74  LDD0403  [1]
 LDCM0087  Capsaicin HEK-293T 5.98  LDD0185  [14]
 LDCM0632  CL-Sc Hep-G2 C73(0.75)  LDD2227  [13]
 LDCM0367  CL1 HEK-293T C73(0.89)  LDD0965  [9]
 LDCM0368  CL10 HEK-293T C73(0.72)  LDD0966  [9]
 LDCM0369  CL100 HCT 116 C73(1.09)  LDD0686  [9]
 LDCM0370  CL101 HCT 116 C73(0.99)  LDD0687  [9]
 LDCM0371  CL102 HCT 116 C73(0.57)  LDD0688  [9]
 LDCM0372  CL103 HCT 116 C73(0.57)  LDD0689  [9]
 LDCM0373  CL104 HCT 116 C73(0.69)  LDD0690  [9]
 LDCM0374  CL105 HCT 116 C73(0.80)  LDD0691  [9]
 LDCM0375  CL106 HCT 116 C73(0.80)  LDD0692  [9]
 LDCM0376  CL107 HCT 116 C73(0.98)  LDD0693  [9]
 LDCM0377  CL108 HCT 116 C73(0.78)  LDD0694  [9]
 LDCM0378  CL109 HCT 116 C73(1.11)  LDD0695  [9]
 LDCM0379  CL11 HEK-293T C73(0.80)  LDD0977  [9]
 LDCM0380  CL110 HCT 116 C73(0.84)  LDD0697  [9]
 LDCM0381  CL111 HCT 116 C73(0.84)  LDD0698  [9]
 LDCM0382  CL112 PaTu 8988t C73(0.99)  LDD1261  [9]
 LDCM0383  CL113 PaTu 8988t C73(1.04)  LDD1262  [9]
 LDCM0384  CL114 PaTu 8988t C73(0.99)  LDD1263  [9]
 LDCM0385  CL115 PaTu 8988t C73(0.97)  LDD1264  [9]
 LDCM0386  CL116 PaTu 8988t C73(1.17)  LDD1265  [9]
 LDCM0387  CL117 HCT 116 C73(0.73)  LDD0704  [9]
 LDCM0388  CL118 HCT 116 C73(1.14)  LDD0705  [9]
 LDCM0389  CL119 HCT 116 C73(1.24)  LDD0706  [9]
 LDCM0390  CL12 HEK-293T C73(0.92)  LDD0988  [9]
 LDCM0391  CL120 HCT 116 C73(1.03)  LDD0708  [9]
 LDCM0392  CL121 HCT 116 C73(1.25)  LDD0709  [9]
 LDCM0393  CL122 HCT 116 C73(1.19)  LDD0710  [9]
 LDCM0394  CL123 HCT 116 C73(0.98)  LDD0711  [9]
 LDCM0395  CL124 HCT 116 C73(1.14)  LDD0712  [9]
 LDCM0396  CL125 HEK-293T C73(1.09)  LDD1600  [26]
 LDCM0397  CL126 HEK-293T C73(1.01)  LDD1601  [26]
 LDCM0398  CL127 HEK-293T C73(1.01)  LDD1602  [26]
 LDCM0399  CL128 HEK-293T C73(1.05)  LDD1603  [26]
 LDCM0400  CL13 HEK-293T C73(0.85)  LDD0998  [9]
 LDCM0401  CL14 HEK-293T C73(0.92)  LDD0999  [9]
 LDCM0402  CL15 HEK-293T C73(0.87)  LDD1000  [9]
 LDCM0403  CL16 PaTu 8988t C73(1.08)  LDD1282  [9]
 LDCM0404  CL17 PaTu 8988t C73(0.97)  LDD1283  [9]
 LDCM0405  CL18 PaTu 8988t C73(1.19)  LDD1284  [9]
 LDCM0406  CL19 PaTu 8988t C73(0.96)  LDD1285  [9]
 LDCM0407  CL2 HEK-293T C73(1.01)  LDD1005  [9]
 LDCM0408  CL20 PaTu 8988t C73(1.09)  LDD1287  [9]
 LDCM0409  CL21 PaTu 8988t C73(1.31)  LDD1288  [9]
 LDCM0410  CL22 PaTu 8988t C73(1.61)  LDD1289  [9]
 LDCM0411  CL23 PaTu 8988t C73(1.43)  LDD1290  [9]
 LDCM0412  CL24 PaTu 8988t C73(0.95)  LDD1291  [9]
 LDCM0413  CL25 PaTu 8988t C73(1.37)  LDD1292  [9]
 LDCM0414  CL26 PaTu 8988t C73(1.14)  LDD1293  [9]
 LDCM0415  CL27 PaTu 8988t C73(1.40)  LDD1294  [9]
 LDCM0416  CL28 PaTu 8988t C73(1.06)  LDD1295  [9]
 LDCM0417  CL29 PaTu 8988t C73(1.03)  LDD1296  [9]
 LDCM0418  CL3 HEK-293T C73(1.03)  LDD1016  [9]
 LDCM0419  CL30 PaTu 8988t C73(1.16)  LDD1298  [9]
 LDCM0420  CL31 HCT 116 C73(1.00)  LDD0737  [9]
 LDCM0421  CL32 HCT 116 C73(0.94)  LDD0738  [9]
 LDCM0422  CL33 HCT 116 C73(1.27)  LDD0739  [9]
 LDCM0423  CL34 HCT 116 C73(1.01)  LDD0740  [9]
 LDCM0424  CL35 HCT 116 C73(0.87)  LDD0741  [9]
 LDCM0425  CL36 HCT 116 C73(0.95)  LDD0742  [9]
 LDCM0426  CL37 HCT 116 C73(0.77)  LDD0743  [9]
 LDCM0428  CL39 HCT 116 C73(0.87)  LDD0745  [9]
 LDCM0429  CL4 HEK-293T C73(1.17)  LDD1027  [9]
 LDCM0430  CL40 HCT 116 C73(0.97)  LDD0747  [9]
 LDCM0431  CL41 HCT 116 C73(0.82)  LDD0748  [9]
 LDCM0432  CL42 HCT 116 C73(1.06)  LDD0749  [9]
 LDCM0433  CL43 HCT 116 C73(1.04)  LDD0750  [9]
 LDCM0434  CL44 HCT 116 C73(0.99)  LDD0751  [9]
 LDCM0435  CL45 HCT 116 C73(0.98)  LDD0752  [9]
 LDCM0436  CL46 HCT 116 C73(0.79)  LDD0753  [9]
 LDCM0437  CL47 HCT 116 C73(0.96)  LDD0754  [9]
 LDCM0438  CL48 HCT 116 C73(0.77)  LDD0755  [9]
 LDCM0439  CL49 HCT 116 C73(0.72)  LDD0756  [9]
 LDCM0440  CL5 HEK-293T C73(0.92)  LDD1038  [9]
 LDCM0441  CL50 HCT 116 C73(0.82)  LDD0758  [9]
 LDCM0442  CL51 HCT 116 C73(0.81)  LDD0759  [9]
 LDCM0443  CL52 HCT 116 C73(0.81)  LDD0760  [9]
 LDCM0444  CL53 HCT 116 C73(1.17)  LDD0761  [9]
 LDCM0445  CL54 HCT 116 C73(0.84)  LDD0762  [9]
 LDCM0446  CL55 HCT 116 C73(0.77)  LDD0763  [9]
 LDCM0447  CL56 HCT 116 C73(1.09)  LDD0764  [9]
 LDCM0448  CL57 HCT 116 C73(1.22)  LDD0765  [9]
 LDCM0449  CL58 HCT 116 C73(0.93)  LDD0766  [9]
 LDCM0450  CL59 HCT 116 C73(0.93)  LDD0767  [9]
 LDCM0451  CL6 HEK-293T C73(1.03)  LDD1049  [9]
 LDCM0452  CL60 HCT 116 C73(0.77)  LDD0769  [9]
 LDCM0453  CL61 HCT 116 C73(0.99)  LDD0770  [9]
 LDCM0454  CL62 HCT 116 C73(1.00)  LDD0771  [9]
 LDCM0455  CL63 HCT 116 C73(1.12)  LDD0772  [9]
 LDCM0456  CL64 HCT 116 C73(1.05)  LDD0773  [9]
 LDCM0457  CL65 HCT 116 C73(1.10)  LDD0774  [9]
 LDCM0458  CL66 HCT 116 C73(0.99)  LDD0775  [9]
 LDCM0459  CL67 HCT 116 C73(1.24)  LDD0776  [9]
 LDCM0460  CL68 HCT 116 C73(1.30)  LDD0777  [9]
 LDCM0461  CL69 HCT 116 C73(1.14)  LDD0778  [9]
 LDCM0462  CL7 HEK-293T C73(0.71)  LDD1060  [9]
 LDCM0463  CL70 HCT 116 C73(1.04)  LDD0780  [9]
 LDCM0464  CL71 HCT 116 C73(1.15)  LDD0781  [9]
 LDCM0465  CL72 HCT 116 C73(1.36)  LDD0782  [9]
 LDCM0466  CL73 HCT 116 C73(1.39)  LDD0783  [9]
 LDCM0467  CL74 HCT 116 C73(1.40)  LDD0784  [9]
 LDCM0469  CL76 HCT 116 C73(1.18)  LDD0786  [9]
 LDCM0470  CL77 HCT 116 C73(1.04)  LDD0787  [9]
 LDCM0471  CL78 HCT 116 C73(1.09)  LDD0788  [9]
 LDCM0472  CL79 HCT 116 C73(1.05)  LDD0789  [9]
 LDCM0473  CL8 HEK-293T C73(2.21)  LDD1071  [9]
 LDCM0474  CL80 HCT 116 C73(0.97)  LDD0791  [9]
 LDCM0475  CL81 HCT 116 C73(1.14)  LDD0792  [9]
 LDCM0476  CL82 HCT 116 C73(0.99)  LDD0793  [9]
 LDCM0477  CL83 HCT 116 C73(0.80)  LDD0794  [9]
 LDCM0478  CL84 HCT 116 C73(0.74)  LDD0795  [9]
 LDCM0479  CL85 HCT 116 C73(0.98)  LDD0796  [9]
 LDCM0480  CL86 HCT 116 C73(1.14)  LDD0797  [9]
 LDCM0481  CL87 HCT 116 C73(1.00)  LDD0798  [9]
 LDCM0482  CL88 HCT 116 C73(1.09)  LDD0799  [9]
 LDCM0483  CL89 HCT 116 C73(0.93)  LDD0800  [9]
 LDCM0484  CL9 HEK-293T C73(1.33)  LDD1082  [9]
 LDCM0485  CL90 HCT 116 C73(1.08)  LDD0802  [9]
 LDCM0486  CL91 HCT 116 C73(0.88)  LDD0803  [9]
 LDCM0487  CL92 HCT 116 C73(0.85)  LDD0804  [9]
 LDCM0488  CL93 HCT 116 C73(0.87)  LDD0805  [9]
 LDCM0489  CL94 HCT 116 C73(0.99)  LDD0806  [9]
 LDCM0490  CL95 HCT 116 C73(0.99)  LDD0807  [9]
 LDCM0491  CL96 HCT 116 C73(1.02)  LDD0808  [9]
 LDCM0492  CL97 HCT 116 C73(1.08)  LDD0809  [9]
 LDCM0493  CL98 HCT 116 C73(0.98)  LDD0810  [9]
 LDCM0494  CL99 HCT 116 C73(0.88)  LDD0811  [9]
 LDCM0193  Compound 36 HEK-293T 4.43  LDD0511  [24]
 LDCM0495  E2913 HEK-293T C73(1.00)  LDD1698  [26]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C73(1.18)  LDD1702  [4]
 LDCM0031  Epigallocatechin gallate HEK-293T 9.20  LDD0183  [14]
 LDCM0625  F8 Ramos C73(2.65)  LDD2187  [27]
 LDCM0573  Fragment11 Ramos C73(0.34)  LDD2190  [27]
 LDCM0576  Fragment14 Ramos C73(0.57)  LDD2193  [27]
 LDCM0586  Fragment28 Ramos C73(1.08)  LDD2198  [27]
 LDCM0468  Fragment33 HCT 116 C73(1.13)  LDD0785  [9]
 LDCM0566  Fragment4 Ramos C73(0.65)  LDD2184  [27]
 LDCM0427  Fragment51 HCT 116 C73(0.94)  LDD0744  [9]
 LDCM0569  Fragment7 Ramos C73(0.61)  LDD2186  [27]
 LDCM0116  HHS-0101 DM93 Y200(1.04)  LDD0264  [6]
 LDCM0117  HHS-0201 DM93 Y200(0.82)  LDD0265  [6]
 LDCM0118  HHS-0301 DM93 Y200(1.36)  LDD0266  [6]
 LDCM0119  HHS-0401 DM93 Y200(1.14)  LDD0267  [6]
 LDCM0120  HHS-0701 DM93 Y200(0.82)  LDD0268  [6]
 LDCM0022  KB02 HCT 116 C73(1.29)  LDD0080  [9]
 LDCM0023  KB03 HCT 116 C73(0.99)  LDD0081  [9]
 LDCM0024  KB05 HCT 116 C73(1.52)  LDD0082  [9]
 LDCM0030  Luteolin HEK-293T 6.22  LDD0182  [14]
 LDCM0109  NEM HeLa N.A.  LDD0223  [8]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C73(0.97)  LDD2092  [4]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C73(1.14)  LDD2094  [4]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C73(0.90)  LDD2098  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C73(0.77)  LDD2109  [4]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C73(2.69)  LDD2153  [4]
 LDCM0627  NUDT7-COV-1 HEK-293T C73(1.33)  LDD2206  [28]
 LDCM0032  Oleacein HEK-293T 4.69  LDD0184  [14]
 LDCM0628  OTUB2-COV-1 HEK-293T C73(1.03)  LDD2207  [28]
 LDCM0131  RA190 MM1.R C73(1.03)  LDD0304  [29]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein arginine N-methyltransferase 5 (PRMT5) Protein arginine N-methyltransferase family O14744
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
FERM domain-containing protein 7 (FRMD7) . Q6ZUT3
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Small nuclear ribonucleoprotein Sm D1 (SNRPD1) SnRNP core protein family P62314
Small nuclear ribonucleoprotein Sm D2 (SNRPD2) SnRNP core protein family P62316
Small nuclear ribonucleoprotein Sm D3 (SNRPD3) SnRNP core protein family P62318
Small nuclear ribonucleoprotein G (SNRPG) SnRNP Sm proteins family P62308
U6 snRNA-associated Sm-like protein LSm2 (LSM2) SnRNP Sm proteins family Q9Y333
U6 snRNA-associated Sm-like protein LSm3 (LSM3) SnRNP Sm proteins family P62310
Small nuclear ribonucleoprotein F (SNRPF) SnRNP Sm proteins family P62306
U6 snRNA-associated Sm-like protein LSm6 (LSM6) SnRNP Sm proteins family P62312
Small nuclear ribonucleoprotein-associated proteins B and B' (SNRPB) SnRNP SmB/SmN family P14678

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
15 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
16 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
17 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
18 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
19 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
20 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
21 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
22 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
23 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
24 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
25 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
26 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
27 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
28 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
29 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.