Details of the Target

General Information of Target

Target ID LDTP02547
Target Name Protein 4.1 (EPB41)
Gene Name EPB41
Gene ID 2035
Synonyms
E41P; Protein 4.1; P4.1; 4.1R; Band 4.1; EPB4.1; Erythrocyte membrane protein band 4.1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTTEKSLVTEAENSQHQQKEEGEEAINSGQQEPQQEESCQTAAEGDNWCEQKLKASNGDT
PTHEDLTKNKERTSESRGLSRLFSSFLKRPKSQVSEEEGKEVESDKEKGEGGQKEIEFGT
SLDEEIILKAPIAAPEPELKTDPSLDLHSLSSAETQPAQEELREDPDFEIKEGEGLEECS
KIEVKEESPQSKAETELKASQKPIRKHRNMHCKVSLLDDTVYECVVEKHAKGQDLLKRVC
EHLNLLEEDYFGLAIWDNATSKTWLDSAKEIKKQVRGVPWNFTFNVKFYPPDPAQLTEDI
TRYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQSELGDYDPELHGVDYVSDFKLAPNQT
KELEEKVMELHKSYRSMTPAQADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGL
LVYKDKLRINRFPWPKVLKISYKRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVC
VEHHTFFRLTSTDTIPKSKFLALGSKFRYSGRTQAQTRQASALIDRPAPHFERTASKRAS
RSLDGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKED
EPPEQAEPEPTEAWKVEKTHIEVTVPTSNGDQTQKLAEKTEDLIRMRKKKRERLDGENIY
IRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNIN
GQIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLD
PGVLLTAQTITSETPSSTTTTQITKTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKE
AKEQHPDMSVTKVVVHQETEIADE
Target Bioclass
Transporter and channel
Subcellular location
Cytoplasm, cytoskeleton
Function
Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase.
Uniprot ID
P11171
Ensemble ID
ENST00000343067.9
HGNC ID
HGNC:3377

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CASKI SNV: p.S555G DBIA    Probe Info 
COLO829 SNV: p.I116R .
FADU SNV: p.T462N DBIA    Probe Info 
HCC827 SNV: p.H16Y DBIA    Probe Info 
HCT116 SNV: p.V625A DBIA    Probe Info 
HS936T SNV: p.Q802L DBIA    Probe Info 
LU65 SNV: p.D774G .
REH SNV: p.R707H .
SUPT1 Deletion: p.G809VfsTer13 DBIA    Probe Info 
SW1271 SNV: p.K354Q DBIA    Probe Info 
TF1 SNV: p.A326E DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DA-P3
 Probe Info  		5.56  LDD0185  [1]
AHL-Pu-1
 Probe Info  		C39(10.48)  LDD0169  [2]
Acrolein
 Probe Info  		N.A.  LDD0221  [3]
DBIA
 Probe Info  		C39(1.04); C49(1.04)  LDD0078  [4]
ATP probe
 Probe Info  		K228(0.00); K231(0.00); K402(0.00); K404(0.00)  LDD0199  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C179(0.00); C480(0.00); C224(0.00); C320(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		C480(0.00); C224(0.00); C306(0.00); C320(0.00)  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C179(0.00); C320(0.00); C480(0.00); C224(0.00)  LDD0037  [6]
IPM
 Probe Info  		C480(0.00); C224(0.00); C179(0.00); C306(0.00)  LDD2156  [7]
VSF
 Probe Info  		N.A.  LDD0007  [8]
AOyne
 Probe Info  		9.50  LDD0443  [9]
NAIA_5
 Probe Info  		N.A.  LDD2223  [10]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		5.65  LDD0471  [11]
FFF probe13
 Probe Info  		5.68  LDD0476  [11]
FFF probe3
 Probe Info  		8.10  LDD0465  [11]
VE-P
 Probe Info  		N.A.  LDD0396  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C39(10.48)  LDD0169  [2]
 LDCM0214  AC1 HCT 116 C39(1.39); C49(1.39)  LDD0531  [4]
 LDCM0215  AC10 HEK-293T C39(1.30); C49(1.29)  LDD0813  [4]
 LDCM0216  AC100 HEK-293T C39(0.95); C49(0.87)  LDD0814  [4]
 LDCM0217  AC101 HEK-293T C39(1.20); C49(0.99)  LDD0815  [4]
 LDCM0218  AC102 HEK-293T C39(1.83); C49(1.18)  LDD0816  [4]
 LDCM0219  AC103 HEK-293T C39(0.78); C49(0.66)  LDD0817  [4]
 LDCM0220  AC104 HEK-293T C39(1.86); C49(1.10)  LDD0818  [4]
 LDCM0221  AC105 HEK-293T C39(1.01); C49(0.81)  LDD0819  [4]
 LDCM0222  AC106 HEK-293T C39(1.80); C49(1.05)  LDD0820  [4]
 LDCM0223  AC107 HEK-293T C39(1.47); C49(1.10)  LDD0821  [4]
 LDCM0224  AC108 HEK-293T C39(1.39); C49(1.10)  LDD0822  [4]
 LDCM0225  AC109 HEK-293T C39(0.99); C49(1.13)  LDD0823  [4]
 LDCM0226  AC11 HEK-293T C39(1.31); C49(1.40)  LDD0824  [4]
 LDCM0227  AC110 HEK-293T C39(3.42); C49(1.05)  LDD0825  [4]
 LDCM0228  AC111 HEK-293T C39(2.11); C49(1.03)  LDD0826  [4]
 LDCM0229  AC112 HEK-293T C39(2.00); C49(1.02)  LDD0827  [4]
 LDCM0230  AC113 HEK-293T C39(0.94); C49(0.89)  LDD0828  [4]
 LDCM0231  AC114 HEK-293T C39(0.89); C49(0.66)  LDD0829  [4]
 LDCM0232  AC115 HEK-293T C39(0.89); C49(0.68)  LDD0830  [4]
 LDCM0233  AC116 HEK-293T C39(0.61); C49(0.55)  LDD0831  [4]
 LDCM0234  AC117 HEK-293T C39(1.14); C49(0.90)  LDD0832  [4]
 LDCM0235  AC118 HEK-293T C39(0.54); C49(0.44)  LDD0833  [4]
 LDCM0236  AC119 HEK-293T C39(0.83); C49(0.67)  LDD0834  [4]
 LDCM0237  AC12 HEK-293T C39(1.53); C49(1.25)  LDD0835  [4]
 LDCM0238  AC120 HEK-293T C39(0.69); C49(0.55)  LDD0836  [4]
 LDCM0239  AC121 HEK-293T C39(0.89); C49(0.85)  LDD0837  [4]
 LDCM0240  AC122 HEK-293T C39(0.91); C49(0.77)  LDD0838  [4]
 LDCM0241  AC123 HEK-293T C39(0.79); C49(0.71)  LDD0839  [4]
 LDCM0242  AC124 HEK-293T C39(1.10); C49(1.03)  LDD0840  [4]
 LDCM0243  AC125 HEK-293T C39(0.88); C49(0.82)  LDD0841  [4]
 LDCM0244  AC126 HEK-293T C39(0.85); C49(0.92)  LDD0842  [4]
 LDCM0245  AC127 HEK-293T C39(0.82); C49(0.91)  LDD0843  [4]
 LDCM0246  AC128 HEK-293T C39(0.94); C49(1.03)  LDD0844  [4]
 LDCM0247  AC129 HEK-293T C39(1.28); C49(1.21)  LDD0845  [4]
 LDCM0249  AC130 HEK-293T C39(1.25); C49(0.96)  LDD0847  [4]
 LDCM0250  AC131 HEK-293T C39(0.97); C49(0.68)  LDD0848  [4]
 LDCM0251  AC132 HEK-293T C39(1.39); C49(1.48)  LDD0849  [4]
 LDCM0252  AC133 HEK-293T C39(0.94); C49(0.69)  LDD0850  [4]
 LDCM0253  AC134 HEK-293T C39(1.06); C49(0.80)  LDD0851  [4]
 LDCM0254  AC135 HEK-293T C39(1.24); C49(0.71)  LDD0852  [4]
 LDCM0255  AC136 HEK-293T C39(1.45); C49(1.17)  LDD0853  [4]
 LDCM0256  AC137 HEK-293T C39(2.14); C49(1.18)  LDD0854  [4]
 LDCM0257  AC138 HEK-293T C39(1.37); C49(1.07)  LDD0855  [4]
 LDCM0258  AC139 HEK-293T C39(1.72); C49(1.20)  LDD0856  [4]
 LDCM0259  AC14 HEK-293T C39(1.34); C49(1.43)  LDD0857  [4]
 LDCM0260  AC140 HEK-293T C39(1.10); C49(0.97)  LDD0858  [4]
 LDCM0261  AC141 HEK-293T C39(1.53); C49(0.98)  LDD0859  [4]
 LDCM0262  AC142 HEK-293T C39(1.49); C49(1.00)  LDD0860  [4]
 LDCM0263  AC143 HCT 116 C39(0.68); C49(0.68)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C39(0.84); C49(0.84)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C39(0.57); C49(0.57)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C39(1.45); C49(1.45)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C39(0.68); C49(0.68)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C39(0.75); C49(0.75)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C39(0.72); C49(0.72)  LDD0586  [4]
 LDCM0270  AC15 HEK-293T C39(1.30); C49(1.39)  LDD0868  [4]
 LDCM0271  AC150 HCT 116 C39(0.84); C49(0.84)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C39(0.85); C49(0.85)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C39(0.78); C49(0.78)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C39(0.75); C49(0.75)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C39(0.80); C49(0.80)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C39(0.82); C49(0.82)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C39(1.02); C49(1.02)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C39(0.91); C49(0.91)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C39(0.60); C49(0.60)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C39(0.48); C49(0.48)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C39(0.45); C49(0.45)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C39(1.23); C49(1.23)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C39(0.58); C49(0.58)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C39(0.48); C49(0.48)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C39(0.37); C49(0.37)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C39(0.42); C49(0.42)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C39(0.43); C49(0.43)  LDD0601  [4]
 LDCM0285  AC25 HEK-293T C39(0.52); C49(0.52)  LDD0883  [4]
 LDCM0286  AC26 HEK-293T C39(0.72); C49(0.72)  LDD0884  [4]
 LDCM0287  AC27 HEK-293T C39(0.68); C49(0.68)  LDD0885  [4]
 LDCM0288  AC28 HEK-293T C39(0.72); C49(0.72)  LDD0886  [4]
 LDCM0289  AC29 HEK-293T C39(0.58); C49(0.58)  LDD0887  [4]
 LDCM0290  AC3 HCT 116 C39(1.23); C49(1.23)  LDD0607  [4]
 LDCM0291  AC30 HEK-293T C39(0.59); C49(0.59)  LDD0889  [4]
 LDCM0292  AC31 HEK-293T C39(0.56); C49(0.56)  LDD0890  [4]
 LDCM0293  AC32 HEK-293T C39(0.82); C49(0.82)  LDD0891  [4]
 LDCM0294  AC33 HEK-293T C39(0.70); C49(0.70)  LDD0892  [4]
 LDCM0295  AC34 HEK-293T C39(0.79); C49(0.79)  LDD0893  [4]
 LDCM0296  AC35 HEK-293T C39(1.02); C49(1.02)  LDD0894  [4]
 LDCM0297  AC36 HEK-293T C39(0.70); C49(0.70)  LDD0895  [4]
 LDCM0298  AC37 HEK-293T C39(0.97); C49(0.97)  LDD0896  [4]
 LDCM0299  AC38 HEK-293T C39(0.98); C49(0.98)  LDD0897  [4]
 LDCM0300  AC39 HEK-293T C39(1.30); C49(1.30)  LDD0898  [4]
 LDCM0301  AC4 HCT 116 C39(1.43); C49(1.43)  LDD0618  [4]
 LDCM0302  AC40 HEK-293T C39(0.72); C49(0.72)  LDD0900  [4]
 LDCM0303  AC41 HEK-293T C39(1.05); C49(1.05)  LDD0901  [4]
 LDCM0304  AC42 HEK-293T C39(0.95); C49(0.95)  LDD0902  [4]
 LDCM0305  AC43 HEK-293T C39(1.03); C49(1.03)  LDD0903  [4]
 LDCM0306  AC44 HEK-293T C39(0.90); C49(0.90)  LDD0904  [4]
 LDCM0307  AC45 HEK-293T C39(1.05); C49(1.05)  LDD0905  [4]
 LDCM0308  AC46 HEK-293T C39(0.91); C49(1.02)  LDD0906  [4]
 LDCM0309  AC47 HEK-293T C39(1.13); C49(1.02)  LDD0907  [4]
 LDCM0310  AC48 HEK-293T C39(1.26); C49(0.91)  LDD0908  [4]
 LDCM0311  AC49 HEK-293T C39(1.56); C49(0.95)  LDD0909  [4]
 LDCM0312  AC5 HCT 116 C39(1.37); C49(1.37)  LDD0629  [4]
 LDCM0313  AC50 HEK-293T C39(2.16); C49(1.06)  LDD0911  [4]
 LDCM0314  AC51 HEK-293T C39(1.48); C49(1.35)  LDD0912  [4]
 LDCM0315  AC52 HEK-293T C39(1.44); C49(1.19)  LDD0913  [4]
 LDCM0316  AC53 HEK-293T C39(1.28); C49(1.18)  LDD0914  [4]
 LDCM0317  AC54 HEK-293T C39(1.28); C49(1.03)  LDD0915  [4]
 LDCM0318  AC55 HEK-293T C39(1.17); C49(0.95)  LDD0916  [4]
 LDCM0319  AC56 HEK-293T C39(1.10); C49(1.03)  LDD0917  [4]
 LDCM0320  AC57 HEK-293T C39(0.81); C49(1.65)  LDD0918  [4]
 LDCM0321  AC58 HEK-293T C39(0.96); C49(1.84)  LDD0919  [4]
 LDCM0322  AC59 HEK-293T C39(0.96); C49(1.91)  LDD0920  [4]
 LDCM0323  AC6 HEK-293T C39(1.76); C49(1.09)  LDD0921  [4]
 LDCM0324  AC60 HEK-293T C39(0.94); C49(3.16)  LDD0922  [4]
 LDCM0325  AC61 HEK-293T C39(0.97); C49(2.41)  LDD0923  [4]
 LDCM0326  AC62 HEK-293T C39(1.02); C49(2.59)  LDD0924  [4]
 LDCM0327  AC63 HEK-293T C39(1.27); C49(2.78)  LDD0925  [4]
 LDCM0328  AC64 HEK-293T C39(1.15); C49(3.27)  LDD0926  [4]
 LDCM0329  AC65 HEK-293T C39(1.19); C49(2.77)  LDD0927  [4]
 LDCM0330  AC66 HEK-293T C39(1.21); C49(2.56)  LDD0928  [4]
 LDCM0331  AC67 HEK-293T C39(1.16); C49(2.15)  LDD0929  [4]
 LDCM0332  AC68 HCT 116 C39(1.11); C49(1.11)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C39(0.91); C49(0.91)  LDD0650  [4]
 LDCM0334  AC7 HEK-293T C39(1.39); C49(0.95)  LDD0932  [4]
 LDCM0335  AC70 HCT 116 C39(1.03); C49(1.03)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C39(1.01); C49(1.01)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C39(0.91); C49(0.91)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C39(0.85); C49(0.85)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C39(0.74); C49(0.74)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C39(1.47); C49(1.47)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C39(0.94); C49(0.94)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C39(0.94); C49(0.94)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C39(0.92); C49(0.92)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C39(1.08); C49(1.08)  LDD0661  [4]
 LDCM0345  AC8 HEK-293T C39(1.66); C49(1.12)  LDD0943  [4]
 LDCM0346  AC80 HCT 116 C39(1.17); C49(1.17)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C39(0.90); C49(0.90)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C39(1.01); C49(1.01)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C39(1.14); C49(1.14)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C39(1.24); C49(1.24)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C39(1.14); C49(1.14)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C39(1.40); C49(1.40)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C39(1.31); C49(1.31)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C39(0.83); C49(0.83)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C39(1.35); C49(1.35)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C39(0.96); C49(0.96)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C39(1.36); C49(1.36)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C39(0.97); C49(0.97)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C39(1.49); C49(1.49)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C39(1.10); C49(1.10)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C39(0.86); C49(0.86)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C39(1.95); C49(1.95)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C39(1.52); C49(1.52)  LDD0681  [4]
 LDCM0365  AC98 HEK-293T C39(1.10); C49(0.94)  LDD0963  [4]
 LDCM0366  AC99 HEK-293T C39(1.72); C49(1.03)  LDD0964  [4]
 LDCM0248  AKOS034007472 HEK-293T C39(1.37); C49(1.39)  LDD0846  [4]
 LDCM0356  AKOS034007680 HEK-293T C39(1.50); C49(1.30)  LDD0954  [4]
 LDCM0275  AKOS034007705 HEK-293T C39(1.74); C49(1.67)  LDD0873  [4]
 LDCM0020  ARS-1620 HCC44 C39(1.04); C49(1.04)  LDD0078  [4]
 LDCM0087  Capsaicin HEK-293T 5.56  LDD0185  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [3]
 LDCM0367  CL1 HEK-293T C39(2.23); C49(1.34)  LDD0965  [4]
 LDCM0368  CL10 HEK-293T C39(2.99); C49(1.71)  LDD0966  [4]
 LDCM0369  CL100 HCT 116 C39(1.55); C49(1.55)  LDD0686  [4]
 LDCM0370  CL101 HEK-293T C39(2.40); C49(0.98)  LDD0968  [4]
 LDCM0371  CL102 HEK-293T C39(1.74); C49(1.54)  LDD0969  [4]
 LDCM0372  CL103 HEK-293T C39(1.54); C49(0.84)  LDD0970  [4]
 LDCM0373  CL104 HEK-293T C39(1.40); C49(0.97)  LDD0971  [4]
 LDCM0374  CL105 HCT 116 C39(0.46); C49(0.46)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C39(0.53); C49(0.53)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C39(0.65); C49(0.65)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C39(0.47); C49(0.47)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C39(0.78); C49(0.78)  LDD0695  [4]
 LDCM0379  CL11 HEK-293T C39(1.83); C49(0.81)  LDD0977  [4]
 LDCM0380  CL110 HCT 116 C39(0.52); C49(0.52)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C39(0.65); C49(0.65)  LDD0698  [4]
 LDCM0382  CL112 HEK-293T C39(0.87); C49(0.87)  LDD0980  [4]
 LDCM0383  CL113 HEK-293T C39(0.69); C49(0.69)  LDD0981  [4]
 LDCM0384  CL114 HEK-293T C39(0.77); C49(0.77)  LDD0982  [4]
 LDCM0385  CL115 HEK-293T C39(0.75); C49(0.75)  LDD0983  [4]
 LDCM0386  CL116 HEK-293T C39(0.63); C49(0.63)  LDD0984  [4]
 LDCM0387  CL117 HEK-293T C39(1.08); C49(1.08)  LDD0985  [4]
 LDCM0388  CL118 HEK-293T C39(0.69); C49(0.69)  LDD0986  [4]
 LDCM0389  CL119 HEK-293T C39(0.72); C49(0.72)  LDD0987  [4]
 LDCM0390  CL12 HEK-293T C39(1.26); C49(1.13)  LDD0988  [4]
 LDCM0391  CL120 HEK-293T C39(0.94); C49(0.94)  LDD0989  [4]
 LDCM0392  CL121 HEK-293T C39(1.16); C49(1.00)  LDD0990  [4]
 LDCM0393  CL122 HEK-293T C39(1.17); C49(0.92)  LDD0991  [4]
 LDCM0394  CL123 HEK-293T C39(1.43); C49(1.28)  LDD0992  [4]
 LDCM0395  CL124 HEK-293T C39(1.17); C49(0.95)  LDD0993  [4]
 LDCM0396  CL125 HEK-293T C39(0.98); C49(1.63)  LDD0994  [4]
 LDCM0397  CL126 HEK-293T C39(0.87); C49(2.08)  LDD0995  [4]
 LDCM0398  CL127 HEK-293T C39(1.05); C49(1.99)  LDD0996  [4]
 LDCM0399  CL128 HEK-293T C39(0.85); C49(1.56)  LDD0997  [4]
 LDCM0400  CL13 HEK-293T C39(1.39); C49(0.83)  LDD0998  [4]
 LDCM0401  CL14 HEK-293T C39(1.86); C49(1.50)  LDD0999  [4]
 LDCM0402  CL15 HEK-293T C39(2.16); C49(1.72)  LDD1000  [4]
 LDCM0403  CL16 HEK-293T C39(1.26); C49(1.08)  LDD1001  [4]
 LDCM0404  CL17 HEK-293T C39(1.14); C49(1.08)  LDD1002  [4]
 LDCM0405  CL18 HEK-293T C39(1.49); C49(1.69)  LDD1003  [4]
 LDCM0406  CL19 HEK-293T C39(1.00); C49(0.80)  LDD1004  [4]
 LDCM0407  CL2 HEK-293T C39(1.47); C49(1.02)  LDD1005  [4]
 LDCM0408  CL20 HEK-293T C39(0.89); C49(0.79)  LDD1006  [4]
 LDCM0409  CL21 HEK-293T C39(1.90); C49(2.56)  LDD1007  [4]
 LDCM0410  CL22 HEK-293T C39(1.21); C49(1.05)  LDD1008  [4]
 LDCM0411  CL23 HEK-293T C39(0.67); C49(0.66)  LDD1009  [4]
 LDCM0412  CL24 HEK-293T C39(0.97); C49(0.98)  LDD1010  [4]
 LDCM0413  CL25 HEK-293T C39(1.31); C49(1.46)  LDD1011  [4]
 LDCM0414  CL26 HEK-293T C39(0.98); C49(0.77)  LDD1012  [4]
 LDCM0415  CL27 HEK-293T C39(1.10); C49(1.09)  LDD1013  [4]
 LDCM0416  CL28 HEK-293T C39(0.76); C49(0.73)  LDD1014  [4]
 LDCM0417  CL29 HEK-293T C39(0.98); C49(1.06)  LDD1015  [4]
 LDCM0418  CL3 HEK-293T C39(2.45); C49(1.19)  LDD1016  [4]
 LDCM0419  CL30 HEK-293T C39(1.20); C49(0.82)  LDD1017  [4]
 LDCM0420  CL31 HEK-293T C39(1.47); C49(1.08)  LDD1018  [4]
 LDCM0421  CL32 HEK-293T C39(1.06); C49(0.98)  LDD1019  [4]
 LDCM0422  CL33 HEK-293T C39(1.61); C49(1.77)  LDD1020  [4]
 LDCM0423  CL34 HEK-293T C39(1.04); C49(0.99)  LDD1021  [4]
 LDCM0424  CL35 HEK-293T C39(1.14); C49(1.09)  LDD1022  [4]
 LDCM0425  CL36 HEK-293T C39(0.97); C49(1.02)  LDD1023  [4]
 LDCM0426  CL37 HEK-293T C39(1.10); C49(1.15)  LDD1024  [4]
 LDCM0428  CL39 HEK-293T C39(1.84); C49(1.20)  LDD1026  [4]
 LDCM0429  CL4 HEK-293T C39(1.29); C49(0.95)  LDD1027  [4]
 LDCM0430  CL40 HEK-293T C39(1.27); C49(0.83)  LDD1028  [4]
 LDCM0431  CL41 HEK-293T C39(1.57); C49(1.15)  LDD1029  [4]
 LDCM0432  CL42 HEK-293T C39(1.28); C49(0.86)  LDD1030  [4]
 LDCM0433  CL43 HEK-293T C39(1.25); C49(0.84)  LDD1031  [4]
 LDCM0434  CL44 HEK-293T C39(1.22); C49(0.85)  LDD1032  [4]
 LDCM0435  CL45 HEK-293T C39(1.40); C49(1.02)  LDD1033  [4]
 LDCM0436  CL46 HCT 116 C39(0.68); C49(0.68)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C39(0.57); C49(0.57)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C39(0.52); C49(0.52)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C39(0.69); C49(0.69)  LDD0756  [4]
 LDCM0440  CL5 HEK-293T C39(1.32); C49(0.93)  LDD1038  [4]
 LDCM0441  CL50 HCT 116 C39(0.67); C49(0.67)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C39(0.66); C49(0.66)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C39(0.75); C49(0.75)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C39(0.76); C49(0.76)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C39(0.88); C49(0.88)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C39(0.69); C49(0.69)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C39(0.57); C49(0.57)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C39(0.65); C49(0.65)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C39(0.63); C49(0.63)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C39(0.63); C49(0.63)  LDD0767  [4]
 LDCM0451  CL6 HEK-293T C39(1.38); C49(1.11)  LDD1049  [4]
 LDCM0452  CL60 HCT 116 C39(0.68); C49(0.68)  LDD0769  [4]
 LDCM0453  CL61 HCT 116 C39(1.46); C49(1.46)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C39(1.32); C49(1.32)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C39(1.15); C49(1.15)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C39(1.62); C49(1.62)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C39(1.15); C49(1.15)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C39(2.12); C49(2.12)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C39(1.20); C49(1.20)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C39(1.43); C49(1.43)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C39(1.03); C49(1.03)  LDD0778  [4]
 LDCM0462  CL7 HEK-293T C39(1.57); C49(0.88)  LDD1060  [4]
 LDCM0463  CL70 HCT 116 C39(1.22); C49(1.22)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C39(1.52); C49(1.52)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C39(1.16); C49(1.16)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C39(1.31); C49(1.31)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C39(1.45); C49(1.45)  LDD0784  [4]
 LDCM0469  CL76 HEK-293T C39(1.04); C49(1.25)  LDD1067  [4]
 LDCM0470  CL77 HEK-293T C39(1.26); C49(1.43)  LDD1068  [4]
 LDCM0471  CL78 HEK-293T C39(1.33); C49(1.03)  LDD1069  [4]
 LDCM0472  CL79 HEK-293T C39(1.28); C49(0.94)  LDD1070  [4]
 LDCM0473  CL8 HEK-293T C39(1.65); C49(1.45)  LDD1071  [4]
 LDCM0474  CL80 HEK-293T C39(0.84); C49(0.72)  LDD1072  [4]
 LDCM0475  CL81 HEK-293T C39(1.07); C49(1.15)  LDD1073  [4]
 LDCM0476  CL82 HEK-293T C39(0.68); C49(0.79)  LDD1074  [4]
 LDCM0477  CL83 HEK-293T C39(1.39); C49(0.75)  LDD1075  [4]
 LDCM0478  CL84 HEK-293T C39(1.38); C49(0.98)  LDD1076  [4]
 LDCM0479  CL85 HEK-293T C39(0.81); C49(0.90)  LDD1077  [4]
 LDCM0480  CL86 HEK-293T C39(1.19); C49(1.07)  LDD1078  [4]
 LDCM0481  CL87 HEK-293T C39(1.25); C49(0.88)  LDD1079  [4]
 LDCM0482  CL88 HEK-293T C39(1.19); C49(1.31)  LDD1080  [4]
 LDCM0483  CL89 HEK-293T C39(1.25); C49(1.17)  LDD1081  [4]
 LDCM0484  CL9 HEK-293T C39(1.60); C49(1.02)  LDD1082  [4]
 LDCM0485  CL90 HEK-293T C39(1.82); C49(1.31)  LDD1083  [4]
 LDCM0486  CL91 HCT 116 C39(1.14); C49(1.14)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C39(1.06); C49(1.06)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C39(0.90); C49(0.90)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C39(1.59); C49(1.59)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C39(1.52); C49(1.52)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C39(1.07); C49(1.07)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C39(1.46); C49(1.46)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C39(1.58); C49(1.58)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C39(1.23); C49(1.23)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C179(0.92); C416(0.95); C224(0.94); C240(1.01)  LDD1698  [13]
 LDCM0468  Fragment33 HCT 116 C39(1.23); C49(1.23)  LDD0785  [4]
 LDCM0427  Fragment51 HEK-293T C39(0.98); C49(0.93)  LDD1025  [4]
 LDCM0107  IAA HeLa N.A.  LDD0221  [3]
 LDCM0022  KB02 HCT 116 C39(2.44); C49(2.44); C179(1.28)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C39(1.30); C49(1.30); C179(0.97)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C39(1.76); C49(1.76); C179(1.34)  LDD0082  [4]
 LDCM0021  THZ1 HCT 116 C39(1.16); C49(1.16)  LDD2173  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
RWD domain-containing protein 2B (RWDD2B) . P57060
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Methylosome subunit pICln (CLNS1A) PICln (TC 1.A.47) family P54105
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger CCHC domain-containing protein 10 (ZCCHC10) . Q8TBK6

References

1 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
12 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402