Details of the Target

General Information of Target

Target ID LDTP12599
Target Name Ubiquitin-like-conjugating enzyme ATG3 (ATG3)
Gene Name ATG3
Gene ID 64422
Synonyms
APG3; APG3L; Ubiquitin-like-conjugating enzyme ATG3; EC 2.3.2.-; Autophagy-related protein 3; APG3-like; hApg3; Protein PC3-96
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGRRRLLVWLCAVAALLSGAQARGTPLLARPAPPGASRYSLYTTGWRPRLRPGPHKALCA
YVVHRNVTCILQEGAESYVKAEYRQCRWGPKCPGTVTYRTVLRPKYKVGYKTVTDLAWRC
CPGFTGKRCPEHLTDHGAASPQLEPEPQIPSGQLDPGPRPPSYSRAAPSPHGRKGPGLFG
ERLERLEGDVQRLAQTYGTLSGLVASHEDPNRMTGGPRAPAVPVGFGVIPEGLVGPGDRA
RGPLTPPLDEILSKVTEVSNTLQTKVQLLDKVHGLALGHEAHLQRLREAPPSPLTSLALL
EEYVDRRLHRLWGSLLDGFEQKLQGVQSECDLRVQEVRRQCEEGQAASRRLHQSLDGREL
ALRQELSQLGSQLQGLSVSGRGSCCGQLALINARMDGLERALQAVTETQRGPGAPAGDEL
TRLSAAMLEGGVDGLLEGLETLNGTEGGARGCCLRLDMGGWGVGGFGTMLEERVQSLEER
LATLAGELSHDSASPGRSARPLVQTELAVLEQRLVSLETSCTPSTTSAILDSLVAEVKAW
QSRSEALLRQVASHAALLQQLNGTVAEVQGQLAEGTGSSLQGEITLLKVNLNSVSKSLTG
LSDSVSQYSDAFLAANTSLDERERKVEAEVQAIQEQVSSQGSRLQAGHRQVLNLRGELEQ
LKAGVAKVASGLSRCQDTAQKLQHTVGHFDQRVAQVEGACRRLGLLAAGLDSLPTEPLRP
REGLWSHVDQLNRTLAQHTQDIARLRDDLLDCQAQLAEQVRPGQAN
Target Bioclass
Enzyme
Family
ATG3 family
Subcellular location
Cytoplasm
Function
E2 conjugating enzyme that catalyzes the covalent conjugation of the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A) to the amino group of phosphatidylethanolamine (PE)-containing lipids in the membrane resulting in membrane-bound ATG8-like proteins which is one of the key steps in the development of autophagic isolation membranes during autophagosome formation. Cycles back and forth between binding to ATG7 for loading with the ATG8-like proteins and binding to E3 enzyme, composed of ATG12, ATG5 and ATG16L1 to promote ATG8-like proteins lipidation. Also plays a role as a membrane curvature sensor that facilitates LC3/GABARAP lipidation by sensing local membrane stress associated with lipid-packing defects as occurs with high molar proportions of conical lipids or strident membrane curvature. Interacts with negatively-charged membranes promoting membrane tethering and enhancing LC3/GABARAP lipidation. Also acts as an autocatalytic E2-like enzyme by catalyzing the conjugation of ATG12 to itself in an ATG7-dependent manner, this complex thus formed, plays a role in mitochondrial homeostasis but not in autophagy. ATG12-ATG3 conjugation promotes late endosome to lysosome trafficking and basal autophagosome maturation via its interaction with PDCD6IP. ATG12-ATG3 conjugate is also formed upon viccina virus infection, leading to the disruption the cellular autophagy which is not necessary for vaccinia survival and proliferation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.
Uniprot ID
Q9NT62
Ensemble ID
ENST00000283290.10
HGNC ID
HGNC:20962

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
KMS11 SNV: p.G190D DBIA    Probe Info 
MFE319 SNV: p.G105D DBIA    Probe Info 
OE33 SNV: p.C182Y .
RL952 SNV: p.C85R DBIA    Probe Info 
SW1573 Insertion: . .
TF1 Insertion: p.L195FfsTer34 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 28 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y209(5.31)  LDD0257  [2]
TH216
 Probe Info  		Y18(20.00)  LDD0259  [2]
STPyne
 Probe Info  		K11(3.64); K131(10.00); K24(10.00); K77(2.40)  LDD0277  [3]
BTD
 Probe Info  		C182(0.78)  LDD1699  [4]
AZ-9
 Probe Info  		D192(10.00)  LDD2209  [5]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [6]
DA-P3
 Probe Info  		4.54  LDD0179  [7]
AHL-Pu-1
 Probe Info  		C182(2.27)  LDD0169  [8]
HHS-475
 Probe Info  		Y18(0.89); Y209(0.95)  LDD0264  [9]
HHS-465
 Probe Info  		Y18(8.58); Y209(10.00)  LDD2237  [10]
DBIA
 Probe Info  		C259(0.60); C264(0.60)  LDD0532  [11]
ATP probe
 Probe Info  		K131(0.00); K185(0.00); K24(0.00); K27(0.00)  LDD0199  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		C50(0.00); C182(0.00)  LDD0038  [13]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [14]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [15]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [13]
WYneN
 Probe Info  		N.A.  LDD0021  [16]
1d-yne
 Probe Info  		N.A.  LDD0356  [17]
ENE
 Probe Info  		N.A.  LDD0006  [16]
IPM
 Probe Info  		N.A.  LDD0005  [16]
PF-06672131
 Probe Info  		N.A.  LDD0017  [18]
SF
 Probe Info  		N.A.  LDD0028  [19]
TFBX
 Probe Info  		C182(0.00); C81(0.00)  LDD0148  [20]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [21]
W1
 Probe Info  		N.A.  LDD0236  [22]
AOyne
 Probe Info  		11.50  LDD0443  [23]
NAIA_5
 Probe Info  		C264(0.00); C259(0.00)  LDD2223  [24]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C409
 Probe Info  		5.78  LDD2066  [25]
STS-2
 Probe Info  		N.A.  LDD0138  [26]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C182(0.77)  LDD2095  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C182(2.27)  LDD0169  [8]
 LDCM0214  AC1 HEK-293T C182(0.84); C259(0.88); C264(0.88)  LDD0812  [11]
 LDCM0215  AC10 HCT 116 C259(0.60); C264(0.60)  LDD0532  [11]
 LDCM0216  AC100 HCT 116 C259(0.55); C264(0.55)  LDD0533  [11]
 LDCM0217  AC101 HCT 116 C259(0.63); C264(0.63)  LDD0534  [11]
 LDCM0218  AC102 HCT 116 C259(0.61); C264(0.61)  LDD0535  [11]
 LDCM0219  AC103 HCT 116 C259(0.51); C264(0.51)  LDD0536  [11]
 LDCM0220  AC104 HCT 116 C259(0.72); C264(0.72)  LDD0537  [11]
 LDCM0221  AC105 HCT 116 C259(0.50); C264(0.50)  LDD0538  [11]
 LDCM0222  AC106 HCT 116 C259(0.47); C264(0.47)  LDD0539  [11]
 LDCM0223  AC107 HCT 116 C259(0.60); C264(0.51)  LDD0540  [11]
 LDCM0224  AC108 HCT 116 C259(0.54); C264(0.63)  LDD0541  [11]
 LDCM0225  AC109 HCT 116 C259(0.51); C264(0.55)  LDD0542  [11]
 LDCM0226  AC11 HCT 116 C259(0.49); C264(0.49)  LDD0543  [11]
 LDCM0227  AC110 HCT 116 C259(0.53); C264(0.55)  LDD0544  [11]
 LDCM0228  AC111 HCT 116 C259(0.54); C264(0.55)  LDD0545  [11]
 LDCM0229  AC112 HCT 116 C259(0.54); C264(0.53)  LDD0546  [11]
 LDCM0230  AC113 HCT 116 C259(0.94); C264(0.94)  LDD0547  [11]
 LDCM0231  AC114 HCT 116 C259(0.82); C264(0.82)  LDD0548  [11]
 LDCM0232  AC115 HCT 116 C259(0.60); C264(0.60)  LDD0549  [11]
 LDCM0233  AC116 HCT 116 C259(0.74); C264(0.74)  LDD0550  [11]
 LDCM0234  AC117 HCT 116 C259(0.70); C264(0.70)  LDD0551  [11]
 LDCM0235  AC118 HCT 116 C259(0.79); C264(0.79)  LDD0552  [11]
 LDCM0236  AC119 HCT 116 C259(0.77); C264(0.77)  LDD0553  [11]
 LDCM0237  AC12 HCT 116 C259(1.41); C264(1.41)  LDD0554  [11]
 LDCM0238  AC120 HCT 116 C259(1.60); C264(1.60)  LDD0555  [11]
 LDCM0239  AC121 HCT 116 C259(0.94); C264(0.94)  LDD0556  [11]
 LDCM0240  AC122 HCT 116 C259(0.79); C264(0.79)  LDD0557  [11]
 LDCM0241  AC123 HCT 116 C259(1.06); C264(1.06)  LDD0558  [11]
 LDCM0242  AC124 HCT 116 C259(0.85); C264(0.85)  LDD0559  [11]
 LDCM0243  AC125 HCT 116 C259(0.69); C264(0.69)  LDD0560  [11]
 LDCM0244  AC126 HCT 116 C259(0.66); C264(0.66)  LDD0561  [11]
 LDCM0245  AC127 HCT 116 C259(0.74); C264(0.74)  LDD0562  [11]
 LDCM0246  AC128 HCT 116 C259(0.63); C264(0.63)  LDD0563  [11]
 LDCM0247  AC129 HCT 116 C259(0.77); C264(0.77)  LDD0564  [11]
 LDCM0249  AC130 HCT 116 C259(0.67); C264(0.67)  LDD0566  [11]
 LDCM0250  AC131 HCT 116 C259(0.86); C264(0.86)  LDD0567  [11]
 LDCM0251  AC132 HCT 116 C259(0.82); C264(0.82)  LDD0568  [11]
 LDCM0252  AC133 HCT 116 C259(0.62); C264(0.62)  LDD0569  [11]
 LDCM0253  AC134 HCT 116 C259(0.64); C264(0.64)  LDD0570  [11]
 LDCM0254  AC135 HCT 116 C259(0.66); C264(0.66)  LDD0571  [11]
 LDCM0255  AC136 HCT 116 C259(1.16); C264(1.16)  LDD0572  [11]
 LDCM0256  AC137 HCT 116 C259(0.83); C264(0.83)  LDD0573  [11]
 LDCM0257  AC138 HCT 116 C259(0.70); C264(0.70)  LDD0574  [11]
 LDCM0258  AC139 HCT 116 C259(0.73); C264(0.73)  LDD0575  [11]
 LDCM0259  AC14 HCT 116 C259(1.17); C264(1.17)  LDD0576  [11]
 LDCM0260  AC140 HCT 116 C259(0.68); C264(0.68)  LDD0577  [11]
 LDCM0261  AC141 HCT 116 C259(0.68); C264(0.68)  LDD0578  [11]
 LDCM0262  AC142 HCT 116 C259(0.60); C264(0.60)  LDD0579  [11]
 LDCM0263  AC143 HCT 116 C259(1.02); C264(1.02)  LDD0580  [11]
 LDCM0264  AC144 HCT 116 C259(0.65); C264(0.65)  LDD0581  [11]
 LDCM0265  AC145 HCT 116 C259(0.87); C264(0.87)  LDD0582  [11]
 LDCM0266  AC146 HCT 116 C259(0.76); C264(0.76)  LDD0583  [11]
 LDCM0267  AC147 HCT 116 C259(0.78); C264(0.78)  LDD0584  [11]
 LDCM0268  AC148 HCT 116 C259(1.08); C264(1.08)  LDD0585  [11]
 LDCM0269  AC149 HCT 116 C259(0.85); C264(0.85)  LDD0586  [11]
 LDCM0270  AC15 HCT 116 C259(0.98); C264(0.98)  LDD0587  [11]
 LDCM0271  AC150 HCT 116 C259(0.94); C264(0.94)  LDD0588  [11]
 LDCM0272  AC151 HCT 116 C259(0.99); C264(0.99)  LDD0589  [11]
 LDCM0273  AC152 HCT 116 C259(0.71); C264(0.71)  LDD0590  [11]
 LDCM0274  AC153 HCT 116 C259(0.89); C264(0.89)  LDD0591  [11]
 LDCM0621  AC154 HCT 116 C259(0.76); C264(0.76)  LDD2158  [11]
 LDCM0622  AC155 HCT 116 C259(0.72); C264(0.72)  LDD2159  [11]
 LDCM0623  AC156 HCT 116 C259(0.78); C264(0.78)  LDD2160  [11]
 LDCM0624  AC157 HCT 116 C259(0.56); C264(0.56)  LDD2161  [11]
 LDCM0276  AC17 HCT 116 C259(0.67); C264(0.67)  LDD0593  [11]
 LDCM0277  AC18 HCT 116 C259(0.98); C264(0.98)  LDD0594  [11]
 LDCM0278  AC19 HCT 116 C259(0.82); C264(0.82)  LDD0595  [11]
 LDCM0279  AC2 HEK-293T C182(1.15); C259(0.85); C264(0.85)  LDD0877  [11]
 LDCM0280  AC20 HCT 116 C259(1.01); C264(1.01)  LDD0597  [11]
 LDCM0281  AC21 HCT 116 C259(1.05); C264(1.05)  LDD0598  [11]
 LDCM0282  AC22 HCT 116 C259(0.95); C264(0.95)  LDD0599  [11]
 LDCM0283  AC23 HCT 116 C259(1.06); C264(1.06)  LDD0600  [11]
 LDCM0284  AC24 HCT 116 C259(0.63); C264(0.63)  LDD0601  [11]
 LDCM0285  AC25 HCT 116 C259(0.77); C264(0.77)  LDD0602  [11]
 LDCM0286  AC26 HCT 116 C259(0.69); C264(0.69)  LDD0603  [11]
 LDCM0287  AC27 HCT 116 C259(0.75); C264(0.75)  LDD0604  [11]
 LDCM0288  AC28 HCT 116 C259(0.83); C264(0.83)  LDD0605  [11]
 LDCM0289  AC29 HCT 116 C259(1.06); C264(1.06)  LDD0606  [11]
 LDCM0290  AC3 HEK-293T C182(1.48); C259(1.49); C264(1.49)  LDD0888  [11]
 LDCM0291  AC30 HCT 116 C259(0.81); C264(0.81)  LDD0608  [11]
 LDCM0292  AC31 HCT 116 C259(0.71); C264(0.71)  LDD0609  [11]
 LDCM0293  AC32 HCT 116 C259(0.75); C264(0.75)  LDD0610  [11]
 LDCM0294  AC33 HCT 116 C259(0.93); C264(0.93)  LDD0611  [11]
 LDCM0295  AC34 HCT 116 C259(0.88); C264(0.88)  LDD0612  [11]
 LDCM0296  AC35 HCT 116 C259(1.30); C264(1.30)  LDD0613  [11]
 LDCM0297  AC36 HCT 116 C259(0.87); C264(0.87)  LDD0614  [11]
 LDCM0298  AC37 HCT 116 C259(0.80); C264(0.80)  LDD0615  [11]
 LDCM0299  AC38 HCT 116 C259(1.22); C264(1.22)  LDD0616  [11]
 LDCM0300  AC39 HCT 116 C259(1.57); C264(1.57)  LDD0617  [11]
 LDCM0301  AC4 HEK-293T C182(0.79); C259(0.90); C264(0.90)  LDD0899  [11]
 LDCM0302  AC40 HCT 116 C259(1.07); C264(1.07)  LDD0619  [11]
 LDCM0303  AC41 HCT 116 C259(0.72); C264(0.72)  LDD0620  [11]
 LDCM0304  AC42 HCT 116 C259(1.38); C264(1.38)  LDD0621  [11]
 LDCM0305  AC43 HCT 116 C259(0.83); C264(0.83)  LDD0622  [11]
 LDCM0306  AC44 HCT 116 C259(0.88); C264(0.88)  LDD0623  [11]
 LDCM0307  AC45 HCT 116 C259(0.94); C264(0.94)  LDD0624  [11]
 LDCM0308  AC46 HCT 116 C259(0.61); C264(0.61)  LDD0625  [11]
 LDCM0309  AC47 HCT 116 C259(0.61); C264(0.61)  LDD0626  [11]
 LDCM0310  AC48 HCT 116 C259(0.38); C264(0.38)  LDD0627  [11]
 LDCM0311  AC49 HCT 116 C259(0.97); C264(0.97)  LDD0628  [11]
 LDCM0312  AC5 HEK-293T C182(1.29); C259(1.18); C264(1.18)  LDD0910  [11]
 LDCM0313  AC50 HCT 116 C259(0.65); C264(0.65)  LDD0630  [11]
 LDCM0314  AC51 HCT 116 C259(0.76); C264(0.76)  LDD0631  [11]
 LDCM0315  AC52 HCT 116 C259(0.75); C264(0.75)  LDD0632  [11]
 LDCM0316  AC53 HCT 116 C259(0.82); C264(0.82)  LDD0633  [11]
 LDCM0317  AC54 HCT 116 C259(1.01); C264(1.01)  LDD0634  [11]
 LDCM0318  AC55 HCT 116 C259(0.56); C264(0.56)  LDD0635  [11]
 LDCM0319  AC56 HCT 116 C259(0.74); C264(0.74)  LDD0636  [11]
 LDCM0320  AC57 HCT 116 C259(0.86); C264(0.86)  LDD0637  [11]
 LDCM0321  AC58 HCT 116 C259(1.22); C264(1.22)  LDD0638  [11]
 LDCM0322  AC59 HCT 116 C259(0.81); C264(0.81)  LDD0639  [11]
 LDCM0323  AC6 HCT 116 C259(0.97); C264(0.97)  LDD0640  [11]
 LDCM0324  AC60 HCT 116 C259(0.60); C264(0.60)  LDD0641  [11]
 LDCM0325  AC61 HCT 116 C259(0.76); C264(0.76)  LDD0642  [11]
 LDCM0326  AC62 HCT 116 C259(0.56); C264(0.56)  LDD0643  [11]
 LDCM0327  AC63 HCT 116 C259(0.73); C264(0.73)  LDD0644  [11]
 LDCM0328  AC64 HCT 116 C259(0.62); C264(0.62)  LDD0645  [11]
 LDCM0329  AC65 HCT 116 C259(0.73); C264(0.73)  LDD0646  [11]
 LDCM0330  AC66 HCT 116 C259(0.97); C264(0.97)  LDD0647  [11]
 LDCM0331  AC67 HCT 116 C259(0.67); C264(0.67)  LDD0648  [11]
 LDCM0332  AC68 HCT 116 C259(1.19); C264(1.19)  LDD0649  [11]
 LDCM0333  AC69 HCT 116 C259(1.13); C264(1.13)  LDD0650  [11]
 LDCM0334  AC7 HCT 116 C259(0.81); C264(0.81)  LDD0651  [11]
 LDCM0335  AC70 HCT 116 C259(1.01); C264(1.01)  LDD0652  [11]
 LDCM0336  AC71 HCT 116 C259(1.02); C264(1.02)  LDD0653  [11]
 LDCM0337  AC72 HCT 116 C259(0.97); C264(0.97)  LDD0654  [11]
 LDCM0338  AC73 HCT 116 C259(1.09); C264(1.09)  LDD0655  [11]
 LDCM0339  AC74 HCT 116 C259(1.22); C264(1.22)  LDD0656  [11]
 LDCM0340  AC75 HCT 116 C259(0.77); C264(0.77)  LDD0657  [11]
 LDCM0341  AC76 HCT 116 C259(1.07); C264(1.07)  LDD0658  [11]
 LDCM0342  AC77 HCT 116 C259(0.98); C264(0.98)  LDD0659  [11]
 LDCM0343  AC78 HCT 116 C259(1.16); C264(1.16)  LDD0660  [11]
 LDCM0344  AC79 HCT 116 C259(0.96); C264(0.96)  LDD0661  [11]
 LDCM0345  AC8 HCT 116 C259(0.93); C264(0.93)  LDD0662  [11]
 LDCM0346  AC80 HCT 116 C259(0.92); C264(0.92)  LDD0663  [11]
 LDCM0347  AC81 HCT 116 C259(1.27); C264(1.27)  LDD0664  [11]
 LDCM0348  AC82 HCT 116 C259(1.69); C264(1.69)  LDD0665  [11]
 LDCM0349  AC83 HCT 116 C259(0.87); C264(0.87)  LDD0666  [11]
 LDCM0350  AC84 HCT 116 C259(0.98); C264(0.98)  LDD0667  [11]
 LDCM0351  AC85 HCT 116 C259(0.74); C264(0.74)  LDD0668  [11]
 LDCM0352  AC86 HCT 116 C259(0.88); C264(0.88)  LDD0669  [11]
 LDCM0353  AC87 HCT 116 C259(1.14); C264(1.14)  LDD0670  [11]
 LDCM0354  AC88 HCT 116 C259(1.16); C264(1.16)  LDD0671  [11]
 LDCM0355  AC89 HCT 116 C259(0.96); C264(0.96)  LDD0672  [11]
 LDCM0357  AC90 HCT 116 C259(0.88); C264(0.88)  LDD0674  [11]
 LDCM0358  AC91 HCT 116 C259(0.75); C264(0.75)  LDD0675  [11]
 LDCM0359  AC92 HCT 116 C259(0.75); C264(0.75)  LDD0676  [11]
 LDCM0360  AC93 HCT 116 C259(0.95); C264(0.95)  LDD0677  [11]
 LDCM0361  AC94 HCT 116 C259(0.73); C264(0.73)  LDD0678  [11]
 LDCM0362  AC95 HCT 116 C259(1.00); C264(1.00)  LDD0679  [11]
 LDCM0363  AC96 HCT 116 C259(0.71); C264(0.71)  LDD0680  [11]
 LDCM0364  AC97 HCT 116 C259(0.69); C264(0.69)  LDD0681  [11]
 LDCM0365  AC98 HCT 116 C259(0.46); C264(0.46)  LDD0682  [11]
 LDCM0366  AC99 HCT 116 C259(0.68); C264(0.68)  LDD0683  [11]
 LDCM0545  Acetamide MDA-MB-231 C182(0.55)  LDD2138  [4]
 LDCM0248  AKOS034007472 HCT 116 C259(0.65); C264(0.65)  LDD0565  [11]
 LDCM0356  AKOS034007680 HCT 116 C259(0.73); C264(0.73)  LDD0673  [11]
 LDCM0275  AKOS034007705 HCT 116 C259(1.16); C264(1.16)  LDD0592  [11]
 LDCM0156  Aniline NCI-H1299 11.67  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C182(0.52); C81(0.47)  LDD2091  [4]
 LDCM0087  Capsaicin HEK-293T 12.89  LDD0185  [7]
 LDCM0632  CL-Sc Hep-G2 C182(0.95)  LDD2227  [24]
 LDCM0367  CL1 PaTu 8988t C259(0.79); C264(0.79)  LDD1246  [11]
 LDCM0368  CL10 PaTu 8988t C259(0.64); C264(0.64)  LDD1247  [11]
 LDCM0369  CL100 HEK-293T C182(1.04); C259(1.21); C264(1.21)  LDD0967  [11]
 LDCM0370  CL101 HCT 116 C259(0.73); C264(0.73)  LDD0687  [11]
 LDCM0371  CL102 HCT 116 C259(0.69); C264(0.69)  LDD0688  [11]
 LDCM0372  CL103 HCT 116 C259(0.71); C264(0.71)  LDD0689  [11]
 LDCM0373  CL104 HCT 116 C259(1.10); C264(1.10)  LDD0690  [11]
 LDCM0374  CL105 HCT 116 C259(0.89); C264(0.89)  LDD0691  [11]
 LDCM0375  CL106 HCT 116 C259(1.49); C264(1.49)  LDD0692  [11]
 LDCM0376  CL107 HCT 116 C259(1.10); C264(1.10)  LDD0693  [11]
 LDCM0377  CL108 HCT 116 C259(0.91); C264(0.91)  LDD0694  [11]
 LDCM0378  CL109 HCT 116 C259(1.13); C264(1.13)  LDD0695  [11]
 LDCM0379  CL11 PaTu 8988t C259(0.72); C264(0.72)  LDD1258  [11]
 LDCM0380  CL110 HCT 116 C259(1.14); C264(1.14)  LDD0697  [11]
 LDCM0381  CL111 HCT 116 C259(0.98); C264(0.98)  LDD0698  [11]
 LDCM0382  CL112 HCT 116 C259(0.87); C264(0.87)  LDD0699  [11]
 LDCM0383  CL113 HCT 116 C259(0.89); C264(0.89)  LDD0700  [11]
 LDCM0384  CL114 HCT 116 C259(1.15); C264(1.15)  LDD0701  [11]
 LDCM0385  CL115 HCT 116 C259(1.12); C264(1.12)  LDD0702  [11]
 LDCM0386  CL116 HCT 116 C259(1.01); C264(1.01)  LDD0703  [11]
 LDCM0387  CL117 HCT 116 C259(1.58); C264(1.58)  LDD0704  [11]
 LDCM0388  CL118 HCT 116 C259(0.78); C264(0.78)  LDD0705  [11]
 LDCM0389  CL119 HCT 116 C259(0.71); C264(0.71)  LDD0706  [11]
 LDCM0390  CL12 PaTu 8988t C259(0.89); C264(0.89)  LDD1269  [11]
 LDCM0391  CL120 HCT 116 C259(0.75); C264(0.75)  LDD0708  [11]
 LDCM0392  CL121 HCT 116 C259(0.61); C264(0.61)  LDD0709  [11]
 LDCM0393  CL122 HCT 116 C259(0.80); C264(0.80)  LDD0710  [11]
 LDCM0394  CL123 HCT 116 C259(0.74); C264(0.74)  LDD0711  [11]
 LDCM0395  CL124 HCT 116 C259(0.84); C264(0.84)  LDD0712  [11]
 LDCM0396  CL125 HCT 116 C259(0.61); C264(0.61)  LDD0713  [11]
 LDCM0397  CL126 HCT 116 C259(0.94); C264(0.94)  LDD0714  [11]
 LDCM0398  CL127 HCT 116 C259(0.83); C264(0.83)  LDD0715  [11]
 LDCM0399  CL128 HCT 116 C259(0.75); C264(0.75)  LDD0716  [11]
 LDCM0400  CL13 PaTu 8988t C259(0.77); C264(0.77)  LDD1279  [11]
 LDCM0401  CL14 PaTu 8988t C259(0.80); C264(0.80)  LDD1280  [11]
 LDCM0402  CL15 PaTu 8988t C259(0.67); C264(0.67)  LDD1281  [11]
 LDCM0403  CL16 HCT 116 C259(0.82); C264(0.82)  LDD0720  [11]
 LDCM0404  CL17 HCT 116 C259(0.74); C264(0.74)  LDD0721  [11]
 LDCM0405  CL18 HCT 116 C259(0.61); C264(0.61)  LDD0722  [11]
 LDCM0406  CL19 HCT 116 C259(0.81); C264(0.81)  LDD0723  [11]
 LDCM0407  CL2 PaTu 8988t C259(0.77); C264(0.77)  LDD1286  [11]
 LDCM0408  CL20 HCT 116 C259(0.66); C264(0.66)  LDD0725  [11]
 LDCM0409  CL21 HCT 116 C259(0.58); C264(0.58)  LDD0726  [11]
 LDCM0410  CL22 HCT 116 C259(0.72); C264(0.72)  LDD0727  [11]
 LDCM0411  CL23 HCT 116 C259(0.75); C264(0.75)  LDD0728  [11]
 LDCM0412  CL24 HCT 116 C259(0.75); C264(0.75)  LDD0729  [11]
 LDCM0413  CL25 HCT 116 C259(0.71); C264(0.71)  LDD0730  [11]
 LDCM0414  CL26 HCT 116 C259(0.80); C264(0.80)  LDD0731  [11]
 LDCM0415  CL27 HCT 116 C259(0.64); C264(0.64)  LDD0732  [11]
 LDCM0416  CL28 HCT 116 C259(0.75); C264(0.75)  LDD0733  [11]
 LDCM0417  CL29 HCT 116 C259(0.61); C264(0.61)  LDD0734  [11]
 LDCM0418  CL3 PaTu 8988t C259(0.40); C264(0.40)  LDD1297  [11]
 LDCM0419  CL30 HCT 116 C259(0.91); C264(0.91)  LDD0736  [11]
 LDCM0420  CL31 HCT 116 C259(0.85); C264(0.85)  LDD0737  [11]
 LDCM0421  CL32 HCT 116 C259(0.57); C264(0.57)  LDD0738  [11]
 LDCM0422  CL33 HCT 116 C259(0.68); C264(0.68)  LDD0739  [11]
 LDCM0423  CL34 HCT 116 C259(0.69); C264(0.69)  LDD0740  [11]
 LDCM0424  CL35 HCT 116 C259(0.67); C264(0.67)  LDD0741  [11]
 LDCM0425  CL36 HCT 116 C259(0.68); C264(0.68)  LDD0742  [11]
 LDCM0426  CL37 HCT 116 C259(0.67); C264(0.67)  LDD0743  [11]
 LDCM0428  CL39 HCT 116 C259(0.64); C264(0.64)  LDD0745  [11]
 LDCM0429  CL4 PaTu 8988t C259(0.46); C264(0.46)  LDD1308  [11]
 LDCM0430  CL40 HCT 116 C259(0.68); C264(0.68)  LDD0747  [11]
 LDCM0431  CL41 HCT 116 C259(0.63); C264(0.63)  LDD0748  [11]
 LDCM0432  CL42 HCT 116 C259(0.89); C264(0.89)  LDD0749  [11]
 LDCM0433  CL43 HCT 116 C259(0.69); C264(0.69)  LDD0750  [11]
 LDCM0434  CL44 HCT 116 C259(0.73); C264(0.73)  LDD0751  [11]
 LDCM0435  CL45 HCT 116 C259(0.58); C264(0.58)  LDD0752  [11]
 LDCM0436  CL46 HCT 116 C259(0.36); C264(0.36)  LDD0753  [11]
 LDCM0437  CL47 HCT 116 C259(0.59); C264(0.59)  LDD0754  [11]
 LDCM0438  CL48 HCT 116 C259(0.43); C264(0.43)  LDD0755  [11]
 LDCM0439  CL49 HCT 116 C259(0.48); C264(0.48)  LDD0756  [11]
 LDCM0440  CL5 PaTu 8988t C259(0.70); C264(0.70)  LDD1319  [11]
 LDCM0441  CL50 HCT 116 C259(0.65); C264(0.65)  LDD0758  [11]
 LDCM0442  CL51 HCT 116 C259(0.36); C264(0.36)  LDD0759  [11]
 LDCM0443  CL52 HCT 116 C259(0.46); C264(0.46)  LDD0760  [11]
 LDCM0444  CL53 HCT 116 C259(2.13); C264(2.13)  LDD0761  [11]
 LDCM0445  CL54 HCT 116 C259(0.58); C264(0.58)  LDD0762  [11]
 LDCM0446  CL55 HCT 116 C259(0.72); C264(0.72)  LDD0763  [11]
 LDCM0447  CL56 HCT 116 C259(0.89); C264(0.89)  LDD0764  [11]
 LDCM0448  CL57 HCT 116 C259(0.70); C264(0.70)  LDD0765  [11]
 LDCM0449  CL58 HCT 116 C259(0.41); C264(0.41)  LDD0766  [11]
 LDCM0450  CL59 HCT 116 C259(0.52); C264(0.52)  LDD0767  [11]
 LDCM0451  CL6 PaTu 8988t C259(0.77); C264(0.77)  LDD1330  [11]
 LDCM0452  CL60 HCT 116 C259(0.33); C264(0.33)  LDD0769  [11]
 LDCM0453  CL61 HCT 116 C259(0.68); C264(0.68)  LDD0770  [11]
 LDCM0454  CL62 HCT 116 C259(0.58); C264(0.58)  LDD0771  [11]
 LDCM0455  CL63 HCT 116 C259(0.85); C264(0.85)  LDD0772  [11]
 LDCM0456  CL64 HCT 116 C259(0.67); C264(0.67)  LDD0773  [11]
 LDCM0457  CL65 HCT 116 C259(1.07); C264(1.07)  LDD0774  [11]
 LDCM0458  CL66 HCT 116 C259(0.74); C264(0.74)  LDD0775  [11]
 LDCM0459  CL67 HCT 116 C259(1.10); C264(1.10)  LDD0776  [11]
 LDCM0460  CL68 HCT 116 C259(2.86); C264(2.86)  LDD0777  [11]
 LDCM0461  CL69 HCT 116 C259(0.67); C264(0.67)  LDD0778  [11]
 LDCM0462  CL7 PaTu 8988t C259(0.66); C264(0.66)  LDD1341  [11]
 LDCM0463  CL70 HCT 116 C259(1.16); C264(1.16)  LDD0780  [11]
 LDCM0464  CL71 HCT 116 C259(1.03); C264(1.03)  LDD0781  [11]
 LDCM0465  CL72 HCT 116 C259(0.91); C264(0.91)  LDD0782  [11]
 LDCM0466  CL73 HCT 116 C259(0.94); C264(0.94)  LDD0783  [11]
 LDCM0467  CL74 HCT 116 C259(1.24); C264(1.24)  LDD0784  [11]
 LDCM0469  CL76 HCT 116 C259(2.00); C264(2.00)  LDD0786  [11]
 LDCM0470  CL77 HCT 116 C259(2.76); C264(2.76)  LDD0787  [11]
 LDCM0471  CL78 HCT 116 C259(1.45); C264(1.45)  LDD0788  [11]
 LDCM0472  CL79 HCT 116 C259(1.67); C264(1.67)  LDD0789  [11]
 LDCM0473  CL8 PaTu 8988t C259(0.54); C264(0.54)  LDD1352  [11]
 LDCM0474  CL80 HCT 116 C259(1.48); C264(1.48)  LDD0791  [11]
 LDCM0475  CL81 HCT 116 C259(1.14); C264(1.14)  LDD0792  [11]
 LDCM0476  CL82 HCT 116 C259(1.58); C264(1.58)  LDD0793  [11]
 LDCM0477  CL83 HCT 116 C259(1.36); C264(1.36)  LDD0794  [11]
 LDCM0478  CL84 HCT 116 C259(1.12); C264(1.12)  LDD0795  [11]
 LDCM0479  CL85 HCT 116 C259(2.11); C264(2.11)  LDD0796  [11]
 LDCM0480  CL86 HCT 116 C259(2.13); C264(2.13)  LDD0797  [11]
 LDCM0481  CL87 HCT 116 C259(1.86); C264(1.86)  LDD0798  [11]
 LDCM0482  CL88 HCT 116 C259(2.46); C264(2.46)  LDD0799  [11]
 LDCM0483  CL89 HCT 116 C259(2.02); C264(2.02)  LDD0800  [11]
 LDCM0484  CL9 PaTu 8988t C259(0.72); C264(0.72)  LDD1363  [11]
 LDCM0485  CL90 HCT 116 C259(2.43); C264(2.43)  LDD0802  [11]
 LDCM0486  CL91 HEK-293T C182(1.40); C259(0.99); C264(0.99)  LDD1084  [11]
 LDCM0487  CL92 HEK-293T C182(0.76); C259(0.90); C264(0.90)  LDD1085  [11]
 LDCM0488  CL93 HEK-293T C182(1.09); C259(0.89); C264(0.89)  LDD1086  [11]
 LDCM0489  CL94 HEK-293T C182(1.30); C259(0.86); C264(0.86)  LDD1087  [11]
 LDCM0490  CL95 HEK-293T C182(1.05); C259(0.59); C264(0.59)  LDD1088  [11]
 LDCM0491  CL96 HEK-293T C182(1.43); C259(1.15); C264(1.15)  LDD1089  [11]
 LDCM0492  CL97 HEK-293T C182(1.81); C259(1.05); C264(1.05)  LDD1090  [11]
 LDCM0493  CL98 HEK-293T C182(0.99); C259(1.00); C264(1.00)  LDD1091  [11]
 LDCM0494  CL99 HEK-293T C182(0.85); C259(0.77); C264(0.77)  LDD1092  [11]
 LDCM0634  CY-0357 Hep-G2 C182(0.80)  LDD2228  [24]
 LDCM0028  Dobutamine HEK-293T 7.15  LDD0180  [7]
 LDCM0027  Dopamine HEK-293T 4.54  LDD0179  [7]
 LDCM0495  E2913 HEK-293T C50(1.10); C264(1.12)  LDD1698  [27]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C182(0.74)  LDD1702  [4]
 LDCM0031  Epigallocatechin gallate HEK-293T 45.90  LDD0183  [7]
 LDCM0625  F8 Ramos C182(1.45)  LDD2187  [28]
 LDCM0572  Fragment10 Ramos C182(0.99)  LDD2189  [28]
 LDCM0573  Fragment11 Ramos C182(0.45)  LDD2190  [28]
 LDCM0574  Fragment12 Ramos C182(0.80)  LDD2191  [28]
 LDCM0575  Fragment13 Ramos C182(1.12)  LDD2192  [28]
 LDCM0576  Fragment14 Ramos C182(0.93)  LDD2193  [28]
 LDCM0579  Fragment20 Ramos C182(0.73)  LDD2194  [28]
 LDCM0580  Fragment21 Ramos C182(1.05)  LDD2195  [28]
 LDCM0582  Fragment23 Ramos C182(1.59)  LDD2196  [28]
 LDCM0578  Fragment27 Ramos C182(1.12)  LDD2197  [28]
 LDCM0586  Fragment28 Ramos C182(0.54)  LDD2198  [28]
 LDCM0588  Fragment30 Ramos C182(1.38)  LDD2199  [28]
 LDCM0589  Fragment31 Ramos C182(0.91)  LDD2200  [28]
 LDCM0590  Fragment32 Ramos C182(1.28)  LDD2201  [28]
 LDCM0468  Fragment33 HCT 116 C259(0.73); C264(0.73)  LDD0785  [11]
 LDCM0596  Fragment38 Ramos C182(1.11)  LDD2203  [28]
 LDCM0566  Fragment4 Ramos C182(0.83)  LDD2184  [28]
 LDCM0427  Fragment51 HCT 116 C259(0.78); C264(0.78)  LDD0744  [11]
 LDCM0610  Fragment52 Ramos C182(1.21)  LDD2204  [28]
 LDCM0614  Fragment56 Ramos C182(1.34)  LDD2205  [28]
 LDCM0569  Fragment7 Ramos C182(0.83)  LDD2186  [28]
 LDCM0571  Fragment9 Ramos C182(0.86)  LDD2188  [28]
 LDCM0116  HHS-0101 DM93 Y18(0.89); Y209(0.95)  LDD0264  [9]
 LDCM0117  HHS-0201 DM93 Y209(0.76); Y18(1.06)  LDD0265  [9]
 LDCM0118  HHS-0301 DM93 Y18(0.70); Y209(0.73)  LDD0266  [9]
 LDCM0119  HHS-0401 DM93 Y18(0.79); Y209(0.88)  LDD0267  [9]
 LDCM0120  HHS-0701 DM93 Y209(0.70); Y18(1.01)  LDD0268  [9]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [6]
 LDCM0022  KB02 HEK-293T C182(1.23); C264(1.08); C50(0.97); C259(0.92)  LDD1492  [27]
 LDCM0023  KB03 HEK-293T C182(1.00); C264(0.98); C50(1.05); C259(0.96)  LDD1497  [27]
 LDCM0024  KB05 MKN-1 C81(1.31)  LDD3331  [29]
 LDCM0030  Luteolin HEK-293T 17.25  LDD0182  [7]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C182(1.02)  LDD2093  [4]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C182(0.37)  LDD2096  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C182(0.73)  LDD2107  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C182(0.77)  LDD2111  [4]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C182(0.59)  LDD2116  [4]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C182(0.62)  LDD2118  [4]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C182(0.96)  LDD2120  [4]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C182(0.49)  LDD2122  [4]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C182(0.47)  LDD2124  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C182(0.52); C81(0.66)  LDD2128  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C182(0.54)  LDD2140  [4]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C81(0.76)  LDD2143  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C182(0.64)  LDD2144  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C182(0.72)  LDD2146  [4]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C182(0.58)  LDD2149  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C182(0.56)  LDD2150  [4]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C182(0.98)  LDD2151  [4]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C182(2.64)  LDD2153  [4]
 LDCM0032  Oleacein HEK-293T 10.09  LDD0184  [7]
 LDCM0628  OTUB2-COV-1 HEK-293T C182(0.46)  LDD2207  [30]
 LDCM0029  Quercetin HEK-293T 8.63  LDD0181  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquitin-like protein ATG12 (ATG12) ATG12 family O94817
Gamma-aminobutyric acid receptor-associated protein (GABARAP) ATG8 family O95166
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (GNB2) WD repeat G protein beta family P62879
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1) ATG8 family Q9H0R8
Gamma-aminobutyric acid receptor-associated protein-like 2 (GABARAPL2) ATG8 family P60520
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) ATG8 family Q9GZQ8
MOB kinase activator 2 (MOB2) MOB1/phocein family Q70IA6
Tectonin beta-propeller repeat-containing protein 1 (TECPR1) TECPR1 family Q7Z6L1

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
6 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
7 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
10 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
11 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
12 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
15 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
16 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
17 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
18 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
19 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
20 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
21 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
22 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
23 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
24 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
25 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
26 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
27 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
28 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
29 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
30 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.