Details of the Target

General Information of Target

Target ID LDTP02984
Target Name 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1)
Gene Name PLCG1
Gene ID 5335
Synonyms
PLC1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; EC 3.1.4.11; PLC-148; Phosphoinositide phospholipase C-gamma-1; Phospholipase C-II; PLC-II; Phospholipase C-gamma-1; PLC-gamma-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI
TWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL
SLQATSEDEVNMWIKGLTWLMEDTLQAPTPLQIERWLRKQFYSVDRNREDRISAKDLKNM
LSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRA
GERPELCRVSLPEFQQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVT
FLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG
CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIA
QQRNMAQYFKKVLGDTLLTKPVEISADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSMM
YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEVSS
STELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW
RNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT
NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE
GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP
GFYVEANPMPTFKCAVKALFDYKAQREDELTFIKSAIIQNVEKQEGGWWRGDYGGKKQLW
FPSNYVEEMVNPVALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSIS
MASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKIMERRKKIALELSELVVYC
RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDS
SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMRDEAFDPFDKS
SLRGLEPCAISIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVW
PAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDL
ELASLLIKIDIFPAKENGDLSPFSGTSLRERGSDASGQLFHGRAREGSFESRYQQPFEDF
RISQEHLADHFDSRERRAPRRTRVNGDNRL
Target Bioclass
Enzyme
Subcellular location
Cell projection, lamellipodium
Function
Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration. Guanine nucleotide exchange factor that binds the GTPase DNM1 and catalyzes the dissociation of GDP, allowing a GTP molecule to bind in its place, therefore enhancing DNM1-dependent endocytosis.
Uniprot ID
P19174
Ensemble ID
ENST00000244007.7
HGNC ID
HGNC:9065
ChEMBL ID
CHEMBL3964

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 23 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
CY-1
 Probe Info  		100.00  LDD0243  [1]
TH211
 Probe Info  		Y1253(20.00)  LDD0260  [2]
STPyne
 Probe Info  		K178(0.50); K990(7.20)  LDD0277  [3]
Probe 1
 Probe Info  		Y186(6.01); Y481(7.62); Y771(16.02); Y1253(14.85)  LDD3495  [4]
DBIA
 Probe Info  		C247(1.47); C881(1.77)  LDD3311  [5]
BTD
 Probe Info  		C247(1.25)  LDD1700  [6]
Sulforaphane-probe2
 Probe Info  		1.92  LDD0160  [7]
DA-P3
 Probe Info  		4.48  LDD0180  [8]
HHS-475
 Probe Info  		Y1253(0.53); Y783(0.63); Y428(0.97); Y845(0.97)  LDD0264  [9]
HHS-465
 Probe Info  		Y1253(10.00); Y428(9.71)  LDD2237  [10]
Acrolein
 Probe Info  		N.A.  LDD0221  [11]
ATP probe
 Probe Info  		N.A.  LDD0199  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		C247(0.00); C646(0.00); C417(0.00); C1109(0.00)  LDD0038  [13]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [14]
IPIAA_L
 Probe Info  		C247(0.00); C1088(0.00)  LDD0031  [15]
Lodoacetamide azide
 Probe Info  		C247(0.00); C646(0.00); C417(0.00); C1109(0.00)  LDD0037  [13]
NAIA_4
 Probe Info  		N.A.  LDD2226  [16]
ENE
 Probe Info  		N.A.  LDD0006  [17]
IPM
 Probe Info  		N.A.  LDD0005  [17]
SF
 Probe Info  		N.A.  LDD0028  [18]
TFBX
 Probe Info  		C1088(0.00); C247(0.00); C608(0.00)  LDD0148  [19]
VSF
 Probe Info  		N.A.  LDD0007  [17]
NAIA_5
 Probe Info  		C1109(0.00); C1088(0.00); C881(0.00); C1060(0.00)  LDD2223  [16]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C349
 Probe Info  		10.20  LDD2010  [20]
FFF probe13
 Probe Info  		14.12  LDD0476  [21]
FFF probe3
 Probe Info  		8.23  LDD0465  [21]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C247(0.65); C881(0.59)  LDD2095  [6]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C247(0.90)  LDD2130  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C247(0.98)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C247(1.14)  LDD2152  [6]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C247(0.63); C881(0.37)  LDD2132  [6]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C247(0.67); C881(1.22)  LDD2131  [6]
 LDCM0214  AC1 HEK-293T C247(0.97); C646(1.00); C106(1.07); C1088(0.88)  LDD1507  [22]
 LDCM0215  AC10 HEK-293T C247(0.95); C646(0.98); C106(1.03); C1088(0.96)  LDD1508  [22]
 LDCM0226  AC11 HEK-293T C247(0.93); C646(1.07); C106(0.95); C1088(1.19)  LDD1509  [22]
 LDCM0237  AC12 HEK-293T C247(1.04); C646(1.12); C106(1.09); C1088(0.92)  LDD1510  [22]
 LDCM0259  AC14 HEK-293T C247(0.98); C646(0.99); C106(1.10); C1088(0.98)  LDD1512  [22]
 LDCM0270  AC15 HEK-293T C247(0.93); C646(1.11); C106(1.05); C1088(1.01)  LDD1513  [22]
 LDCM0276  AC17 HEK-293T C247(0.96); C646(1.03); C106(1.01); C1088(0.85)  LDD1515  [22]
 LDCM0277  AC18 HEK-293T C247(0.95); C646(0.95); C106(0.87); C1088(1.08)  LDD1516  [22]
 LDCM0278  AC19 HEK-293T C247(0.82); C646(1.69); C106(1.07); C1088(0.78)  LDD1517  [22]
 LDCM0279  AC2 HEK-293T C247(0.98); C646(0.96); C106(1.12); C1088(0.83)  LDD1518  [22]
 LDCM0280  AC20 HEK-293T C247(0.98); C646(1.06); C106(1.03); C1088(0.84)  LDD1519  [22]
 LDCM0281  AC21 HEK-293T C247(0.99); C646(1.02); C106(0.94); C1088(1.14)  LDD1520  [22]
 LDCM0282  AC22 HEK-293T C247(0.99); C646(1.02); C106(0.94); C1088(1.15)  LDD1521  [22]
 LDCM0283  AC23 HEK-293T C247(0.98); C646(1.05); C106(0.98); C1088(0.90)  LDD1522  [22]
 LDCM0284  AC24 HEK-293T C247(1.01); C646(0.99); C106(1.11); C1088(0.92)  LDD1523  [22]
 LDCM0285  AC25 HEK-293T C247(0.92); C646(1.05); C106(1.11); C1088(0.90)  LDD1524  [22]
 LDCM0286  AC26 HEK-293T C247(1.03); C646(0.91); C106(1.02); C1088(0.97)  LDD1525  [22]
 LDCM0287  AC27 HEK-293T C247(0.92); C646(1.06); C106(1.19); C1088(1.10)  LDD1526  [22]
 LDCM0288  AC28 HEK-293T C247(0.94); C646(1.05); C106(1.04); C1088(0.93)  LDD1527  [22]
 LDCM0289  AC29 HEK-293T C247(1.03); C646(0.96); C106(1.01); C1088(1.02)  LDD1528  [22]
 LDCM0290  AC3 HEK-293T C247(0.89); C646(1.04); C106(1.11); C1088(1.04)  LDD1529  [22]
 LDCM0291  AC30 HEK-293T C247(0.97); C646(0.94); C106(1.01); C1088(1.02)  LDD1530  [22]
 LDCM0292  AC31 HEK-293T C247(0.90); C646(1.02); C106(0.92); C1088(0.98)  LDD1531  [22]
 LDCM0293  AC32 HEK-293T C247(0.93); C646(1.00); C106(1.01); C1088(0.95)  LDD1532  [22]
 LDCM0294  AC33 HEK-293T C247(0.94); C646(1.02); C106(0.98); C1088(0.86)  LDD1533  [22]
 LDCM0295  AC34 HEK-293T C247(0.99); C646(0.96); C106(1.10); C1088(0.94)  LDD1534  [22]
 LDCM0296  AC35 HEK-293T C247(0.93); C646(1.07); C106(1.03); C1088(0.81)  LDD1535  [22]
 LDCM0297  AC36 HEK-293T C247(1.03); C646(1.13); C106(1.00); C1088(0.80)  LDD1536  [22]
 LDCM0298  AC37 HEK-293T C247(0.92); C646(1.00); C106(1.09); C1088(0.98)  LDD1537  [22]
 LDCM0299  AC38 HEK-293T C247(0.91); C646(0.97); C106(0.95); C1088(0.93)  LDD1538  [22]
 LDCM0300  AC39 HEK-293T C247(0.91); C646(1.02); C106(0.89); C1088(0.98)  LDD1539  [22]
 LDCM0301  AC4 HEK-293T C247(1.04); C646(1.03); C106(1.05); C1088(0.85)  LDD1540  [22]
 LDCM0302  AC40 HEK-293T C247(0.96); C646(1.04); C106(0.95); C1088(0.99)  LDD1541  [22]
 LDCM0303  AC41 HEK-293T C247(0.91); C646(1.06); C106(1.09); C1088(0.94)  LDD1542  [22]
 LDCM0304  AC42 HEK-293T C247(0.99); C646(1.06); C106(1.09); C1088(0.90)  LDD1543  [22]
 LDCM0305  AC43 HEK-293T C247(0.90); C646(1.05); C106(0.96); C1088(0.94)  LDD1544  [22]
 LDCM0306  AC44 HEK-293T C247(0.98); C646(1.11); C106(1.04); C1088(0.99)  LDD1545  [22]
 LDCM0307  AC45 HEK-293T C247(0.92); C646(0.99); C106(1.05); C1088(0.97)  LDD1546  [22]
 LDCM0308  AC46 HEK-293T C247(0.95); C646(1.07); C106(1.00); C1088(0.86)  LDD1547  [22]
 LDCM0309  AC47 HEK-293T C247(0.92); C646(1.02); C106(0.97); C1088(1.07)  LDD1548  [22]
 LDCM0310  AC48 HEK-293T C247(0.97); C646(1.10); C106(0.93); C1088(0.91)  LDD1549  [22]
 LDCM0311  AC49 HEK-293T C247(0.89); C646(1.14); C106(0.89); C1088(1.09)  LDD1550  [22]
 LDCM0312  AC5 HEK-293T C247(0.87); C646(0.96); C106(0.99); C1088(0.87)  LDD1551  [22]
 LDCM0313  AC50 HEK-293T C247(0.98); C646(0.96); C106(1.08); C1088(0.99)  LDD1552  [22]
 LDCM0314  AC51 HEK-293T C247(0.89); C646(1.09); C106(1.23); C1088(0.96)  LDD1553  [22]
 LDCM0315  AC52 HEK-293T C247(0.96); C646(1.04); C106(1.08); C1088(0.98)  LDD1554  [22]
 LDCM0316  AC53 HEK-293T C247(0.93); C646(1.03); C106(1.01); C1088(0.95)  LDD1555  [22]
 LDCM0317  AC54 HEK-293T C247(0.97); C646(1.05); C106(0.93); C1088(0.96)  LDD1556  [22]
 LDCM0318  AC55 HEK-293T C247(0.95); C646(1.11); C106(0.92); C1088(1.01)  LDD1557  [22]
 LDCM0319  AC56 HEK-293T C247(0.98); C646(1.05); C106(1.00); C1088(0.88)  LDD1558  [22]
 LDCM0320  AC57 HEK-293T C247(0.94); C646(1.02); C106(1.01); C1088(0.88)  LDD1559  [22]
 LDCM0321  AC58 HEK-293T C247(0.98); C646(0.97); C106(1.08); C1088(0.96)  LDD1560  [22]
 LDCM0322  AC59 HEK-293T C247(0.95); C646(0.99); C106(1.02); C1088(1.05)  LDD1561  [22]
 LDCM0323  AC6 HEK-293T C247(0.96); C646(1.01); C106(1.01); C1088(0.90)  LDD1562  [22]
 LDCM0324  AC60 HEK-293T C247(0.94); C646(1.04); C106(0.94); C1088(0.96)  LDD1563  [22]
 LDCM0325  AC61 HEK-293T C247(0.92); C646(1.05); C106(0.95); C1088(0.86)  LDD1564  [22]
 LDCM0326  AC62 HEK-293T C247(0.97); C646(0.91); C106(1.05); C1088(1.12)  LDD1565  [22]
 LDCM0327  AC63 HEK-293T C247(0.94); C646(1.00); C106(1.06); C1088(0.98)  LDD1566  [22]
 LDCM0328  AC64 HEK-293T C247(0.95); C646(1.09); C106(0.92); C1088(0.94)  LDD1567  [22]
 LDCM0334  AC7 HEK-293T C247(0.96); C646(1.06); C106(1.01); C1088(1.02)  LDD1568  [22]
 LDCM0345  AC8 HEK-293T C247(0.97); C646(1.00); C106(1.10); C1088(1.17)  LDD1569  [22]
 LDCM0545  Acetamide MDA-MB-231 C247(0.48); C881(0.55)  LDD2138  [6]
 LDCM0520  AKOS000195272 MDA-MB-231 C247(0.80)  LDD2113  [6]
 LDCM0248  AKOS034007472 HEK-293T C247(0.99); C646(1.05); C106(0.94); C1088(1.10)  LDD1511  [22]
 LDCM0356  AKOS034007680 HEK-293T C247(0.92); C646(1.09); C106(1.03); C1088(0.80)  LDD1570  [22]
 LDCM0275  AKOS034007705 HEK-293T C247(0.96); C646(1.07); C106(1.01); C1088(1.02)  LDD1514  [22]
 LDCM0498  BS-3668 MDA-MB-231 C247(0.48); C881(0.68)  LDD2091  [6]
 LDCM0087  Capsaicin HEK-293T 18.64  LDD0185  [8]
 LDCM0108  Chloroacetamide HeLa C573(0.00); C1088(0.00)  LDD0222  [11]
 LDCM0632  CL-Sc Hep-G2 C247(20.00)  LDD2227  [16]
 LDCM0367  CL1 HEK-293T C247(0.82); C646(0.88); C106(1.10); C1088(1.05)  LDD1571  [22]
 LDCM0368  CL10 HEK-293T C247(0.76); C646(0.85); C106(1.14); C1088(1.17)  LDD1572  [22]
 LDCM0369  CL100 HEK-293T C247(0.91); C646(1.04); C106(0.83); C1088(0.96)  LDD1573  [22]
 LDCM0370  CL101 HEK-293T C247(0.91); C646(1.11); C106(0.99); C1088(0.87)  LDD1574  [22]
 LDCM0371  CL102 HEK-293T C247(1.07); C646(1.02); C106(0.91); C881(1.01)  LDD1575  [22]
 LDCM0372  CL103 HEK-293T C247(1.01); C646(1.00); C106(0.94); C1088(0.98)  LDD1576  [22]
 LDCM0373  CL104 HEK-293T C247(0.95); C646(1.03); C106(0.91); C1088(1.03)  LDD1577  [22]
 LDCM0374  CL105 HEK-293T C247(0.92); C646(1.05); C106(1.00); C1088(0.95)  LDD1578  [22]
 LDCM0375  CL106 HEK-293T C247(1.07); C646(1.05); C106(1.00); C881(1.11)  LDD1579  [22]
 LDCM0376  CL107 HEK-293T C247(0.98); C646(0.98); C106(1.06); C1088(1.21)  LDD1580  [22]
 LDCM0377  CL108 HEK-293T C247(0.95); C646(1.05); C106(0.81); C1088(1.00)  LDD1581  [22]
 LDCM0378  CL109 HEK-293T C247(0.90); C646(1.28); C106(1.03); C1088(0.81)  LDD1582  [22]
 LDCM0379  CL11 HEK-293T C247(0.88); C646(0.96); C106(1.05); C1088(1.05)  LDD1583  [22]
 LDCM0380  CL110 HEK-293T C247(0.81); C646(1.01); C106(0.83); C881(1.00)  LDD1584  [22]
 LDCM0381  CL111 HEK-293T C247(1.00); C646(0.99); C106(0.90); C1088(0.92)  LDD1585  [22]
 LDCM0382  CL112 HEK-293T C247(0.93); C646(1.16); C106(0.87); C1088(1.07)  LDD1586  [22]
 LDCM0383  CL113 HEK-293T C247(0.99); C646(1.01); C106(1.11); C1088(0.88)  LDD1587  [22]
 LDCM0384  CL114 HEK-293T C247(1.02); C646(0.99); C106(0.88); C881(1.15)  LDD1588  [22]
 LDCM0385  CL115 HEK-293T C247(1.00); C646(1.05); C106(1.21); C1088(0.94)  LDD1589  [22]
 LDCM0386  CL116 HEK-293T C247(0.88); C646(1.06); C106(0.97); C1088(1.04)  LDD1590  [22]
 LDCM0387  CL117 HEK-293T C247(0.96); C646(1.06); C106(1.04); C1088(0.85)  LDD1591  [22]
 LDCM0388  CL118 HEK-293T C247(0.90); C646(1.01); C106(0.98); C881(1.11)  LDD1592  [22]
 LDCM0389  CL119 HEK-293T C247(0.99); C646(0.95); C106(1.00); C1088(1.43)  LDD1593  [22]
 LDCM0390  CL12 HEK-293T C247(0.89); C646(0.98); C106(1.12); C1088(0.97)  LDD1594  [22]
 LDCM0391  CL120 HEK-293T C247(0.95); C646(1.07); C106(0.97); C1088(1.08)  LDD1595  [22]
 LDCM0392  CL121 HEK-293T C247(0.91); C646(1.13); C106(0.99); C1088(0.98)  LDD1596  [22]
 LDCM0393  CL122 HEK-293T C247(1.11); C646(1.10); C106(0.96); C881(0.98)  LDD1597  [22]
 LDCM0394  CL123 HEK-293T C247(0.85); C646(0.98); C106(0.91); C1088(1.06)  LDD1598  [22]
 LDCM0395  CL124 HEK-293T C247(0.92); C646(1.12); C106(0.86); C1088(0.99)  LDD1599  [22]
 LDCM0396  CL125 HEK-293T C247(0.90); C646(1.05); C106(1.15); C1088(1.13)  LDD1600  [22]
 LDCM0397  CL126 HEK-293T C247(0.95); C646(0.99); C106(0.87); C881(1.23)  LDD1601  [22]
 LDCM0398  CL127 HEK-293T C247(0.97); C646(0.97); C106(0.99); C1088(1.18)  LDD1602  [22]
 LDCM0399  CL128 HEK-293T C247(0.96); C646(1.01); C106(0.81); C1088(0.96)  LDD1603  [22]
 LDCM0400  CL13 HEK-293T C247(0.86); C646(0.96); C106(1.10); C1088(1.22)  LDD1604  [22]
 LDCM0401  CL14 HEK-293T C247(1.18); C646(0.97); C106(0.97); C881(1.16)  LDD1605  [22]
 LDCM0402  CL15 HEK-293T C247(0.86); C646(1.00); C106(1.03); C1088(1.01)  LDD1606  [22]
 LDCM0403  CL16 HEK-293T C247(0.89); C646(0.99); C106(0.77); C1088(0.97)  LDD1607  [22]
 LDCM0404  CL17 HEK-293T C247(0.75); C646(0.96); C106(1.12); C1088(0.93)  LDD1608  [22]
 LDCM0405  CL18 HEK-293T C247(0.93); C646(0.98); C106(1.03); C1088(0.92)  LDD1609  [22]
 LDCM0406  CL19 HEK-293T C247(1.00); C646(1.11); C106(1.03); C1088(1.23)  LDD1610  [22]
 LDCM0407  CL2 HEK-293T C247(1.43); C646(0.90); C106(0.85); C881(0.99)  LDD1611  [22]
 LDCM0408  CL20 HEK-293T C247(1.02); C646(1.03); C106(1.20); C1088(1.01)  LDD1612  [22]
 LDCM0409  CL21 HEK-293T C247(0.84); C646(1.08); C106(1.00); C1088(1.01)  LDD1613  [22]
 LDCM0410  CL22 HEK-293T C247(0.88); C646(1.08); C106(1.31); C1088(0.93)  LDD1614  [22]
 LDCM0411  CL23 HEK-293T C247(0.92); C646(0.99); C106(1.00); C1088(1.06)  LDD1615  [22]
 LDCM0412  CL24 HEK-293T C247(0.94); C646(0.99); C106(1.24); C1088(1.09)  LDD1616  [22]
 LDCM0413  CL25 HEK-293T C247(0.84); C646(0.97); C106(0.96); C1088(0.98)  LDD1617  [22]
 LDCM0414  CL26 HEK-293T C247(1.00); C646(0.99); C106(0.86); C881(1.02)  LDD1618  [22]
 LDCM0415  CL27 HEK-293T C247(0.97); C646(1.01); C106(1.01); C1088(0.89)  LDD1619  [22]
 LDCM0416  CL28 HEK-293T C247(1.03); C646(1.07); C106(0.89); C1088(0.91)  LDD1620  [22]
 LDCM0417  CL29 HEK-293T C247(0.96); C646(1.08); C106(0.98); C1088(0.96)  LDD1621  [22]
 LDCM0418  CL3 HEK-293T C247(0.93); C646(1.06); C106(1.01); C1088(0.92)  LDD1622  [22]
 LDCM0419  CL30 HEK-293T C247(1.04); C646(0.98); C106(0.96); C1088(1.02)  LDD1623  [22]
 LDCM0420  CL31 HEK-293T C247(0.90); C646(1.08); C106(0.96); C1088(0.91)  LDD1624  [22]
 LDCM0421  CL32 HEK-293T C247(1.08); C646(1.13); C106(1.13); C1088(0.83)  LDD1625  [22]
 LDCM0422  CL33 HEK-293T C247(0.89); C646(0.95); C106(1.02); C1088(1.16)  LDD1626  [22]
 LDCM0423  CL34 HEK-293T C247(0.94); C646(1.14); C106(1.15); C1088(1.04)  LDD1627  [22]
 LDCM0424  CL35 HEK-293T C247(1.02); C646(1.09); C106(1.00); C1088(1.06)  LDD1628  [22]
 LDCM0425  CL36 HEK-293T C247(0.99); C646(1.03); C106(0.94); C1088(0.96)  LDD1629  [22]
 LDCM0426  CL37 HEK-293T C247(0.95); C646(0.94); C106(1.04); C1088(1.11)  LDD1630  [22]
 LDCM0428  CL39 HEK-293T C247(0.97); C646(0.89); C106(0.83); C1088(1.48)  LDD1632  [22]
 LDCM0429  CL4 HEK-293T C247(0.85); C646(0.96); C106(1.02); C1088(1.11)  LDD1633  [22]
 LDCM0430  CL40 HEK-293T C247(1.00); C646(0.96); C106(0.78); C1088(1.11)  LDD1634  [22]
 LDCM0431  CL41 HEK-293T C247(0.90); C646(1.11); C106(1.02); C1088(1.16)  LDD1635  [22]
 LDCM0432  CL42 HEK-293T C247(1.05); C646(0.90); C106(1.13); C1088(1.02)  LDD1636  [22]
 LDCM0433  CL43 HEK-293T C247(0.92); C646(1.04); C106(1.00); C1088(0.97)  LDD1637  [22]
 LDCM0434  CL44 HEK-293T C247(1.10); C646(1.02); C106(1.09); C1088(0.82)  LDD1638  [22]
 LDCM0435  CL45 HEK-293T C247(0.92); C646(1.03); C106(0.99); C1088(0.89)  LDD1639  [22]
 LDCM0436  CL46 HEK-293T C247(0.96); C646(1.07); C106(1.00); C1088(1.09)  LDD1640  [22]
 LDCM0437  CL47 HEK-293T C247(0.98); C646(1.01); C106(0.94); C1088(1.04)  LDD1641  [22]
 LDCM0438  CL48 HEK-293T C247(0.97); C646(1.03); C106(1.06); C1088(0.99)  LDD1642  [22]
 LDCM0439  CL49 HEK-293T C247(0.87); C646(1.03); C106(1.02); C1088(1.05)  LDD1643  [22]
 LDCM0440  CL5 HEK-293T C247(0.91); C646(0.99); C106(1.11); C1088(0.92)  LDD1644  [22]
 LDCM0441  CL50 HEK-293T C247(0.79); C646(1.03); C106(0.96); C881(0.97)  LDD1645  [22]
 LDCM0443  CL52 HEK-293T C247(0.94); C646(1.04); C106(1.04); C1088(1.12)  LDD1646  [22]
 LDCM0444  CL53 HEK-293T C247(0.83); C646(1.13); C106(1.18); C1088(0.83)  LDD1647  [22]
 LDCM0445  CL54 HEK-293T C247(0.85); C646(1.04); C106(1.00); C1088(1.02)  LDD1648  [22]
 LDCM0446  CL55 HEK-293T C247(0.94); C646(1.11); C106(1.05); C1088(1.07)  LDD1649  [22]
 LDCM0447  CL56 HEK-293T C247(0.98); C646(1.07); C106(1.06); C1088(1.03)  LDD1650  [22]
 LDCM0448  CL57 HEK-293T C247(0.77); C646(0.93); C106(0.99); C1088(0.87)  LDD1651  [22]
 LDCM0449  CL58 HEK-293T C247(0.88); C646(1.16); C106(1.09); C1088(1.28)  LDD1652  [22]
 LDCM0450  CL59 HEK-293T C247(0.91); C646(1.10); C106(1.06); C1088(1.04)  LDD1653  [22]
 LDCM0451  CL6 HEK-293T C247(0.88); C646(0.91); C106(0.97); C1088(1.09)  LDD1654  [22]
 LDCM0452  CL60 HEK-293T C247(0.93); C646(1.10); C106(1.13); C1088(1.04)  LDD1655  [22]
 LDCM0453  CL61 HEK-293T C247(0.93); C646(0.95); C106(1.06); C1088(1.14)  LDD1656  [22]
 LDCM0454  CL62 HEK-293T C247(0.98); C646(0.96); C106(0.92); C881(1.08)  LDD1657  [22]
 LDCM0455  CL63 HEK-293T C247(0.98); C646(1.02); C106(1.01); C1088(1.14)  LDD1658  [22]
 LDCM0456  CL64 HEK-293T C247(0.89); C646(1.09); C106(0.96); C1088(1.03)  LDD1659  [22]
 LDCM0457  CL65 HEK-293T C247(0.92); C646(1.03); C106(1.03); C1088(0.89)  LDD1660  [22]
 LDCM0458  CL66 HEK-293T C247(0.97); C646(0.97); C106(1.19); C1088(1.05)  LDD1661  [22]
 LDCM0459  CL67 HEK-293T C247(0.98); C646(1.06); C106(1.04); C1088(0.91)  LDD1662  [22]
 LDCM0460  CL68 HEK-293T C247(1.00); C646(1.10); C106(1.08); C1088(1.05)  LDD1663  [22]
 LDCM0461  CL69 HEK-293T C247(0.88); C646(1.02); C106(1.03); C1088(1.03)  LDD1664  [22]
 LDCM0462  CL7 HEK-293T C247(0.99); C646(1.00); C106(1.02); C1088(1.10)  LDD1665  [22]
 LDCM0463  CL70 HEK-293T C247(0.97); C646(1.03); C106(1.15); C1088(0.98)  LDD1666  [22]
 LDCM0464  CL71 HEK-293T C247(0.91); C646(1.24); C106(0.99); C1088(0.92)  LDD1667  [22]
 LDCM0465  CL72 HEK-293T C247(0.95); C646(1.05); C106(1.01); C1088(1.06)  LDD1668  [22]
 LDCM0466  CL73 HEK-293T C247(0.88); C646(0.95); C106(1.02); C1088(1.03)  LDD1669  [22]
 LDCM0467  CL74 HEK-293T C247(1.40); C646(1.08); C106(0.95); C881(1.00)  LDD1670  [22]
 LDCM0469  CL76 HEK-293T C247(0.94); C646(1.03); C106(0.92); C1088(1.04)  LDD1672  [22]
 LDCM0470  CL77 HEK-293T C247(0.84); C646(1.09); C106(0.93); C1088(0.79)  LDD1673  [22]
 LDCM0471  CL78 HEK-293T C247(0.98); C646(0.97); C106(1.01); C1088(0.97)  LDD1674  [22]
 LDCM0472  CL79 HEK-293T C247(0.91); C646(1.10); C106(1.02); C1088(0.96)  LDD1675  [22]
 LDCM0473  CL8 HEK-293T C247(0.75); C646(0.81); C106(1.00); C1088(0.74)  LDD1676  [22]
 LDCM0474  CL80 HEK-293T C247(1.08); C646(1.06); C106(1.07); C1088(1.08)  LDD1677  [22]
 LDCM0475  CL81 HEK-293T C247(0.97); C646(1.06); C106(1.14); C1088(1.10)  LDD1678  [22]
 LDCM0476  CL82 HEK-293T C247(0.92); C646(1.05); C106(1.01); C1088(0.86)  LDD1679  [22]
 LDCM0477  CL83 HEK-293T C247(0.93); C646(1.11); C106(1.02); C1088(1.03)  LDD1680  [22]
 LDCM0478  CL84 HEK-293T C247(0.92); C646(1.07); C106(0.97); C1088(1.06)  LDD1681  [22]
 LDCM0479  CL85 HEK-293T C247(0.88); C646(1.01); C106(1.14); C1088(0.90)  LDD1682  [22]
 LDCM0480  CL86 HEK-293T C247(0.80); C646(0.90); C106(1.03); C881(0.96)  LDD1683  [22]
 LDCM0481  CL87 HEK-293T C247(0.87); C646(0.95); C106(1.11); C1088(0.99)  LDD1684  [22]
 LDCM0482  CL88 HEK-293T C247(0.90); C646(1.03); C106(1.03); C1088(0.97)  LDD1685  [22]
 LDCM0483  CL89 HEK-293T C247(0.88); C646(1.06); C106(1.05); C1088(1.01)  LDD1686  [22]
 LDCM0484  CL9 HEK-293T C247(0.88); C646(0.98); C106(1.06); C1088(1.00)  LDD1687  [22]
 LDCM0485  CL90 HEK-293T C247(0.78); C646(0.82); C106(0.98); C1088(1.07)  LDD1688  [22]
 LDCM0486  CL91 HEK-293T C247(0.93); C646(0.99); C106(1.11); C1088(0.99)  LDD1689  [22]
 LDCM0487  CL92 HEK-293T C247(0.98); C646(0.99); C106(0.98); C1088(1.08)  LDD1690  [22]
 LDCM0488  CL93 HEK-293T C247(0.87); C646(0.92); C106(1.15); C1088(1.06)  LDD1691  [22]
 LDCM0489  CL94 HEK-293T C247(0.91); C646(0.96); C106(1.02); C1088(0.71)  LDD1692  [22]
 LDCM0490  CL95 HEK-293T C247(0.78); C646(1.65); C106(0.99); C1088(1.02)  LDD1693  [22]
 LDCM0491  CL96 HEK-293T C247(0.87); C646(0.99); C106(1.19); C1088(0.95)  LDD1694  [22]
 LDCM0492  CL97 HEK-293T C247(0.92); C646(1.18); C106(0.98); C1088(0.88)  LDD1695  [22]
 LDCM0493  CL98 HEK-293T C247(0.85); C646(0.98); C106(0.95); C881(1.08)  LDD1696  [22]
 LDCM0494  CL99 HEK-293T C247(1.00); C646(0.97); C106(1.00); C1088(0.98)  LDD1697  [22]
 LDCM0634  CY-0357 Hep-G2 C646(1.07)  LDD2228  [16]
 LDCM0028  Dobutamine HEK-293T 4.48  LDD0180  [8]
 LDCM0495  E2913 HEK-293T C247(0.96); C646(0.87); C106(0.96); C1088(1.12)  LDD1698  [22]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C247(1.17); C881(1.00)  LDD1702  [6]
 LDCM0031  Epigallocatechin gallate HEK-293T 46.21  LDD0183  [8]
 LDCM0625  F8 Ramos C646(1.22)  LDD2187  [23]
 LDCM0573  Fragment11 Ramos C646(5.29)  LDD2190  [23]
 LDCM0576  Fragment14 Ramos C646(0.50)  LDD2193  [23]
 LDCM0468  Fragment33 HEK-293T C247(0.91); C646(1.06); C106(0.96); C1088(0.93)  LDD1671  [22]
 LDCM0566  Fragment4 Ramos C646(1.05)  LDD2184  [23]
 LDCM0427  Fragment51 HEK-293T C247(0.92); C646(0.98); C106(1.00); C881(1.01)  LDD1631  [22]
 LDCM0569  Fragment7 Ramos C646(1.82)  LDD2186  [23]
 LDCM0116  HHS-0101 DM93 Y1253(0.53); Y783(0.63); Y428(0.97); Y845(0.97)  LDD0264  [9]
 LDCM0117  HHS-0201 DM93 Y428(0.88); Y845(0.91); Y1253(1.00); Y783(1.04)  LDD0265  [9]
 LDCM0118  HHS-0301 DM93 Y783(0.59); Y1253(0.71); Y428(0.98); Y845(1.89)  LDD0266  [9]
 LDCM0119  HHS-0401 DM93 Y783(0.75); Y1253(1.00); Y845(1.04); Y428(1.09)  LDD0267  [9]
 LDCM0120  HHS-0701 DM93 Y1253(0.85); Y481(0.99); Y428(1.02); Y845(1.26)  LDD0268  [9]
 LDCM0107  IAA HeLa N.A.  LDD0221  [11]
 LDCM0022  KB02 HEK-293T C247(0.96); C646(0.93); C881(0.98); C106(1.07)  LDD1492  [22]
 LDCM0023  KB03 HEK-293T C247(1.10); C646(0.98); C881(1.04); C106(0.94)  LDD1497  [22]
 LDCM0024  KB05 G361 C247(1.47); C881(1.77)  LDD3311  [5]
 LDCM0030  Luteolin HEK-293T 12.40  LDD0182  [8]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C247(0.92)  LDD2121  [6]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C881(1.01)  LDD2089  [6]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C881(0.98)  LDD2090  [6]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C247(0.58); C881(0.46)  LDD2096  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C247(0.88); C881(1.04)  LDD2099  [6]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C247(1.55); C881(1.42)  LDD2105  [6]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C881(0.93)  LDD2106  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C247(1.00)  LDD2107  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C247(0.55); C881(0.68)  LDD2109  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C247(0.97)  LDD2111  [6]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C247(0.77)  LDD2115  [6]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C247(0.93)  LDD2118  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C247(2.66)  LDD2119  [6]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C247(0.98); C881(0.80)  LDD2120  [6]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C247(0.77); C881(1.04)  LDD2122  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C247(0.79)  LDD2123  [6]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C247(1.02)  LDD2124  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C247(0.77); C881(1.34)  LDD2125  [6]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C247(0.82)  LDD2126  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C247(1.00)  LDD2127  [6]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C247(1.21); C881(0.85)  LDD2128  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C247(1.03)  LDD2129  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C247(1.24); C881(1.26)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C247(1.23); C881(1.19)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C247(0.97); C881(0.77)  LDD2137  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C247(1.25)  LDD1700  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C247(0.79); C881(0.68)  LDD2140  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C247(0.98); C881(0.94)  LDD2143  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C247(0.80)  LDD2146  [6]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C881(2.12)  LDD2147  [6]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C881(0.89)  LDD2149  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C247(0.51)  LDD2150  [6]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C881(0.97)  LDD2151  [6]
 LDCM0032  Oleacein HEK-293T 9.26  LDD0184  [8]
 LDCM0628  OTUB2-COV-1 HEK-293T C646(0.69)  LDD2207  [24]
 LDCM0029  Quercetin HEK-293T 9.66  LDD0181  [8]
 LDCM0003  Sulforaphane MDA-MB-231 1.92  LDD0160  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
RAC-alpha serine/threonine-protein kinase (AKT1) AGC Ser/Thr protein kinase family P31749
Mitogen-activated protein kinase kinase kinase kinase 1 (MAP4K1) STE Ser/Thr protein kinase family Q92918
Hepatocyte growth factor receptor (MET) Tyr protein kinase family P08581
Tyrosine-protein kinase ABL2 (ABL2) Tyr protein kinase family P42684
Mast/stem cell growth factor receptor Kit (KIT) Tyr protein kinase family P10721
Platelet-derived growth factor receptor beta (PDGFRB) Tyr protein kinase family P09619
Epidermal growth factor receptor (EGFR) Tyr protein kinase family P00533
Receptor tyrosine-protein kinase erbB-2 (ERBB2) Tyr protein kinase family P04626
Receptor tyrosine-protein kinase erbB-3 (ERBB3) Tyr protein kinase family P21860
Fibroblast growth factor receptor 1 (FGFR1) Tyr protein kinase family P11362
High affinity nerve growth factor receptor (NTRK1) Tyr protein kinase family P04629
Insulin receptor (INSR) Tyr protein kinase family P06213
Tyrosine-protein kinase SYK (SYK) Tyr protein kinase family P43405
Dual specificity protein phosphatase 15 (DUSP15) Protein-tyrosine phosphatase family Q9H1R2
Ras-related C3 botulinum toxin substrate 1 (RAC1) Rho family P63000
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Caveolin-1 (CAV1) Caveolin family Q03135
Sorting nexin-17 (SNX17) Sorting nexin family Q15036
SH3 and multiple ankyrin repeat domains protein 3 (SHANK3) . Q9BYB0
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Androgen receptor (AR) Nuclear hormone receptor family P10275
Immunoglobulin
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
B-cell receptor CD22 (CD22) SIGLEC (sialic acid binding Ig-like lectin) family P20273
Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B) . P31994
Natural killer cell receptor 2B4 (CD244) . Q9BZW8
Other
Click To Hide/Show 13 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
GRB2-associated-binding protein 1 (GAB1) GAB family Q13480
Growth factor receptor-bound protein 2 (GRB2) GRB2/sem-5/DRK family P62993
KH domain-containing, RNA-binding, signal transduction-associated protein 1 (KHDRBS1) KHDRBS family Q07666
Ras and Rab interactor 3 (RIN3) RIN (Ras interaction/interference) family Q8TB24
SH3 and multiple ankyrin repeat domains protein 2 (SHANK2) SHANK family Q9UPX8
Villin-1 (VIL1) Villin/gelsolin family P09327
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (ASAP1) . Q9ULH1
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 (ASAP2) . O43150
Linker for activation of T-cells family member 1 (LAT) . O43561
Lymphocyte cytosolic protein 2 (LCP2) . Q13094
SH2 domain-containing protein 1B (SH2D1B) . O14796
Son of sevenless homolog 1 (SOS1) . Q07889
Son of sevenless homolog 2 (SOS2) . Q07890

References

1 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
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Mass spectrometry data entry: PXD047840
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.
Mass spectrometry data entry: PXD006279
8 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
9 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
10 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
11 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
12 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
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Mass spectrometry data entry: PXD028853
14 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
15 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
16 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
17 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
18 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
19 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
20 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
21 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
22 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
23 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
24 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.