Details of the Target

General Information of Target

Target ID LDTP03481
Target Name DNA-3-methyladenine glycosylase (MPG)
Gene Name MPG
Gene ID 4350
Synonyms
AAG; ANPG; MID1; DNA-3-methyladenine glycosylase; EC 3.2.2.21; 3-alkyladenine DNA glycosylase; 3-methyladenine DNA glycosidase; ADPG; N-methylpurine-DNA glycosylase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVTPALQMKKPKQFCRRMGQKKQRPARAGQPHSSSDAAQAPAEQPHSSSDAAQAPCPRER
CLGPPTTPGPYRSIYFSSPKGHLTRLGLEFFDQPAVPLARAFLGQVLVRRLPNGTELRGR
IVETEAYLGPEDEAAHSRGGRQTPRNRGMFMKPGTLYVYIIYGMYFCMNISSQGDGACVL
LRALEPLEGLETMRQLRSTLRKGTASRVLKDRELCSGPSKLCQALAINKSFDQRDLAQDE
AVWLERGPLEPSEPAVVAAARVGVGHAGEWARKPLRFYVRGSPWVSVVDRVAEQDTQA
Target Bioclass
Enzyme
Family
DNA glycosylase MPG family
Subcellular location
Cytoplasm
Function Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.
Uniprot ID
P29372
Ensemble ID
ENST00000219431.4
HGNC ID
HGNC:7211
ChEMBL ID
CHEMBL3396943

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 25 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
C-Sul
 Probe Info  		121.37  LDD0066  [2]
BTD
 Probe Info  		C215(0.46)  LDD2109  [3]
DA-P3
 Probe Info  		11.21  LDD0179  [4]
AHL-Pu-1
 Probe Info  		C56(3.04)  LDD0169  [5]
EA-probe
 Probe Info  		N.A.  LDD0440  [6]
DBIA
 Probe Info  		C61(0.95)  LDD0533  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [8]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [9]
NAIA_4
 Probe Info  		C56(0.00); C61(0.00)  LDD2226  [10]
TFBX
 Probe Info  		C61(0.00); C56(0.00)  LDD0027  [9]
WYneN
 Probe Info  		N.A.  LDD0021  [11]
Compound 10
 Probe Info  		C56(0.00); C61(0.00)  LDD2216  [12]
Compound 11
 Probe Info  		C56(0.00); C61(0.00)  LDD2213  [12]
ENE
 Probe Info  		N.A.  LDD0006  [11]
IPM
 Probe Info  		C56(0.00); C61(0.00)  LDD0005  [11]
VSF
 Probe Info  		N.A.  LDD0007  [11]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [13]
Acrolein
 Probe Info  		N.A.  LDD0217  [14]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [14]
Methacrolein
 Probe Info  		N.A.  LDD0218  [14]
AOyne
 Probe Info  		10.00  LDD0443  [15]
NAIA_5
 Probe Info  		C56(0.00); C61(0.00); C222(0.00); C215(0.00)  LDD2223  [10]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C275
 Probe Info  		5.90  LDD1945  [16]
C299
 Probe Info  		6.28  LDD1968  [16]
C304
 Probe Info  		5.86  LDD1973  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C215(1.56)  LDD2117  [3]
 LDCM0025  4SU-RNA DM93 C56(8.02)  LDD0170  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C56(3.04)  LDD0169  [5]
 LDCM0214  AC1 HEK-293T C61(1.37)  LDD0812  [7]
 LDCM0215  AC10 HEK-293T C61(0.97)  LDD0813  [7]
 LDCM0216  AC100 HCT 116 C61(0.95)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C61(0.95)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C61(0.89)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C61(1.30)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C61(0.90)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C61(1.08)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C61(1.12)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C61(1.09)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C61(1.06)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C61(0.78)  LDD0542  [7]
 LDCM0226  AC11 HEK-293T C61(0.97)  LDD0824  [7]
 LDCM0227  AC110 HCT 116 C61(1.28)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C61(0.91)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C61(0.88)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C61(1.03)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C61(1.06)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C61(1.31)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C61(1.42)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C61(1.17)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C61(1.26)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C61(1.22)  LDD0553  [7]
 LDCM0237  AC12 HEK-293T C61(0.89)  LDD0835  [7]
 LDCM0238  AC120 HCT 116 C61(1.27)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C61(1.02)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C61(1.05)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C61(1.13)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C61(1.36)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C61(1.14)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C61(1.56)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C61(1.56)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C61(0.91)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C61(0.86)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C61(0.88)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C61(0.72)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C61(1.03)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C61(1.03)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C61(0.90)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C61(1.00)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C61(0.82)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C61(0.76)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C61(0.95)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C61(1.14)  LDD0575  [7]
 LDCM0259  AC14 HEK-293T C61(0.95)  LDD0857  [7]
 LDCM0260  AC140 HCT 116 C61(1.14)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C61(0.82)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C61(0.97)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C61(1.20)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C61(1.43)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C61(1.21)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C61(1.37)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C61(1.32)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C61(4.59)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C61(2.81)  LDD0586  [7]
 LDCM0270  AC15 HEK-293T C61(0.97)  LDD0868  [7]
 LDCM0271  AC150 HCT 116 C61(1.30)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C61(1.18)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C61(1.35)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C61(2.36)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C61(1.85)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C61(1.58)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C61(1.24)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C61(1.54)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C61(0.88)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C61(1.09)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C61(0.94)  LDD0595  [7]
 LDCM0279  AC2 HEK-293T C61(1.23)  LDD0877  [7]
 LDCM0280  AC20 HCT 116 C61(0.93)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C61(0.94)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C61(0.93)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C61(1.01)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C61(0.85)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C61(0.94)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C61(1.18)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C61(1.38)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C61(1.23)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C61(1.17)  LDD0606  [7]
 LDCM0290  AC3 HEK-293T C61(1.15)  LDD0888  [7]
 LDCM0291  AC30 HCT 116 C61(0.96)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C61(0.99)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C61(0.86)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C61(1.51)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C61(1.20)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C61(1.02)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C61(0.87)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C61(0.90)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C61(1.10)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C61(0.98)  LDD0617  [7]
 LDCM0301  AC4 HEK-293T C61(1.02)  LDD0899  [7]
 LDCM0302  AC40 HCT 116 C61(0.94)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C61(0.99)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C61(0.77)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C61(0.84)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C61(1.33)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C61(0.97)  LDD0624  [7]
 LDCM0308  AC46 HEK-293T C61(1.22)  LDD0906  [7]
 LDCM0309  AC47 HEK-293T C61(1.46)  LDD0907  [7]
 LDCM0310  AC48 HEK-293T C61(1.61)  LDD0908  [7]
 LDCM0311  AC49 HEK-293T C61(1.09)  LDD0909  [7]
 LDCM0312  AC5 HEK-293T C61(1.16)  LDD0910  [7]
 LDCM0313  AC50 HEK-293T C61(1.52)  LDD0911  [7]
 LDCM0314  AC51 HEK-293T C61(1.68)  LDD0912  [7]
 LDCM0315  AC52 HEK-293T C61(1.45)  LDD0913  [7]
 LDCM0316  AC53 HEK-293T C61(1.26)  LDD0914  [7]
 LDCM0317  AC54 HEK-293T C61(1.72)  LDD0915  [7]
 LDCM0318  AC55 HEK-293T C61(1.72)  LDD0916  [7]
 LDCM0319  AC56 HEK-293T C61(1.47)  LDD0917  [7]
 LDCM0320  AC57 HCT 116 C61(1.36)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C61(0.61)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C61(0.77)  LDD0639  [7]
 LDCM0323  AC6 HEK-293T C61(0.98)  LDD0921  [7]
 LDCM0324  AC60 HCT 116 C61(0.77)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C61(0.47)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C61(0.62)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C61(0.74)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C61(0.65)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C61(0.36)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C61(0.34)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C61(0.35)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C61(1.33)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C61(1.39)  LDD0650  [7]
 LDCM0334  AC7 HEK-293T C61(0.79)  LDD0932  [7]
 LDCM0335  AC70 HCT 116 C61(1.66)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C61(1.33)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C61(1.42)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C61(1.67)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C61(1.22)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C61(1.60)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C61(1.25)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C61(1.55)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C61(1.40)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C61(1.25)  LDD0661  [7]
 LDCM0345  AC8 HEK-293T C61(0.76)  LDD0943  [7]
 LDCM0346  AC80 HCT 116 C61(1.29)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C61(1.17)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C61(1.16)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C61(1.55)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C61(1.46)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C61(1.18)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C61(1.28)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C61(1.28)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C61(1.79)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C61(1.89)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C61(1.19)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C61(2.00)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C61(1.88)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C61(1.20)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C61(1.23)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C61(1.40)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C61(1.73)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C61(1.73)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C61(0.91)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C61(1.00)  LDD0683  [7]
 LDCM0248  AKOS034007472 HEK-293T C61(0.87)  LDD0846  [7]
 LDCM0356  AKOS034007680 HEK-293T C61(0.98)  LDD0954  [7]
 LDCM0275  AKOS034007705 HEK-293T C61(0.99)  LDD0873  [7]
 LDCM0156  Aniline NCI-H1299 11.87  LDD0403  [1]
 LDCM0087  Capsaicin HEK-293T 45.82  LDD0185  [4]
 LDCM0632  CL-Sc Hep-G2 C56(0.74)  LDD2227  [10]
 LDCM0369  CL100 HEK-293T C61(1.26)  LDD0967  [7]
 LDCM0370  CL101 HEK-293T C61(0.89)  LDD0968  [7]
 LDCM0371  CL102 HEK-293T C61(0.90)  LDD0969  [7]
 LDCM0372  CL103 HEK-293T C61(0.79)  LDD0970  [7]
 LDCM0373  CL104 HEK-293T C61(1.06)  LDD0971  [7]
 LDCM0374  CL105 HCT 116 C61(1.08)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C61(0.77)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C61(0.88)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C61(0.83)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C61(0.93)  LDD0695  [7]
 LDCM0380  CL110 HCT 116 C61(0.91)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C61(0.81)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C61(1.25)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C61(1.40)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C61(1.33)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C61(0.92)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C61(1.24)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C61(0.68)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C61(0.90)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C61(1.00)  LDD0706  [7]
 LDCM0391  CL120 HCT 116 C61(0.90)  LDD0708  [7]
 LDCM0392  CL121 HEK-293T C61(1.39)  LDD0990  [7]
 LDCM0393  CL122 HEK-293T C61(1.40)  LDD0991  [7]
 LDCM0394  CL123 HEK-293T C61(1.61)  LDD0992  [7]
 LDCM0395  CL124 HEK-293T C61(1.14)  LDD0993  [7]
 LDCM0396  CL125 HCT 116 C61(1.36)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C61(0.77)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C61(1.23)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C61(0.71)  LDD0716  [7]
 LDCM0403  CL16 HCT 116 C61(1.05)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C61(0.91)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C61(0.99)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C61(0.93)  LDD0723  [7]
 LDCM0408  CL20 HCT 116 C61(1.20)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C61(1.14)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C61(0.93)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C61(1.16)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C61(1.00)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C61(1.06)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C61(1.08)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C61(1.25)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C61(1.16)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C61(1.09)  LDD0734  [7]
 LDCM0419  CL30 HCT 116 C61(1.12)  LDD0736  [7]
 LDCM0420  CL31 HEK-293T C61(0.93)  LDD1018  [7]
 LDCM0421  CL32 HEK-293T C61(1.01)  LDD1019  [7]
 LDCM0422  CL33 HEK-293T C61(1.67)  LDD1020  [7]
 LDCM0423  CL34 HEK-293T C61(1.03)  LDD1021  [7]
 LDCM0424  CL35 HEK-293T C61(1.00)  LDD1022  [7]
 LDCM0425  CL36 HEK-293T C61(1.14)  LDD1023  [7]
 LDCM0426  CL37 HEK-293T C61(1.11)  LDD1024  [7]
 LDCM0428  CL39 HEK-293T C61(1.39)  LDD1026  [7]
 LDCM0430  CL40 HEK-293T C61(1.30)  LDD1028  [7]
 LDCM0431  CL41 HEK-293T C61(1.64)  LDD1029  [7]
 LDCM0432  CL42 HEK-293T C61(1.50)  LDD1030  [7]
 LDCM0433  CL43 HEK-293T C61(1.56)  LDD1031  [7]
 LDCM0434  CL44 HEK-293T C61(1.25)  LDD1032  [7]
 LDCM0435  CL45 HEK-293T C61(1.23)  LDD1033  [7]
 LDCM0436  CL46 HCT 116 C61(0.77)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C61(0.75)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C61(0.72)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C61(0.69)  LDD0756  [7]
 LDCM0441  CL50 HCT 116 C61(0.77)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C61(0.79)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C61(0.98)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C61(0.87)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C61(0.96)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C61(0.85)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C61(0.96)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C61(0.77)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C61(0.99)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C61(0.92)  LDD0767  [7]
 LDCM0452  CL60 HCT 116 C61(0.96)  LDD0769  [7]
 LDCM0453  CL61 HEK-293T C61(0.87)  LDD1051  [7]
 LDCM0454  CL62 HEK-293T C61(0.81)  LDD1052  [7]
 LDCM0455  CL63 HEK-293T C61(0.83)  LDD1053  [7]
 LDCM0456  CL64 HEK-293T C61(0.93)  LDD1054  [7]
 LDCM0457  CL65 HEK-293T C61(0.90)  LDD1055  [7]
 LDCM0458  CL66 HEK-293T C61(0.96)  LDD1056  [7]
 LDCM0459  CL67 HEK-293T C61(1.06)  LDD1057  [7]
 LDCM0460  CL68 HEK-293T C61(1.04)  LDD1058  [7]
 LDCM0461  CL69 HEK-293T C61(1.02)  LDD1059  [7]
 LDCM0463  CL70 HEK-293T C61(0.90)  LDD1061  [7]
 LDCM0464  CL71 HEK-293T C61(0.97)  LDD1062  [7]
 LDCM0465  CL72 HEK-293T C61(1.01)  LDD1063  [7]
 LDCM0466  CL73 HEK-293T C61(1.00)  LDD1064  [7]
 LDCM0467  CL74 HEK-293T C61(0.92)  LDD1065  [7]
 LDCM0469  CL76 HCT 116 C61(0.79)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C61(0.85)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C61(0.98)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C61(0.83)  LDD0789  [7]
 LDCM0474  CL80 HCT 116 C61(0.85)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C61(0.86)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C61(0.80)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C61(0.75)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C61(1.06)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C61(0.90)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C61(0.85)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C61(0.83)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C61(0.98)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C61(1.05)  LDD0800  [7]
 LDCM0485  CL90 HCT 116 C61(0.85)  LDD0802  [7]
 LDCM0486  CL91 HEK-293T C61(0.88)  LDD1084  [7]
 LDCM0487  CL92 HEK-293T C61(1.12)  LDD1085  [7]
 LDCM0488  CL93 HEK-293T C61(0.95)  LDD1086  [7]
 LDCM0489  CL94 HEK-293T C61(1.03)  LDD1087  [7]
 LDCM0490  CL95 HEK-293T C61(1.83)  LDD1088  [7]
 LDCM0491  CL96 HEK-293T C61(1.12)  LDD1089  [7]
 LDCM0492  CL97 HEK-293T C61(1.10)  LDD1090  [7]
 LDCM0493  CL98 HEK-293T C61(0.97)  LDD1091  [7]
 LDCM0494  CL99 HEK-293T C61(1.05)  LDD1092  [7]
 LDCM0634  CY-0357 Hep-G2 C61(0.96); C56(0.78)  LDD2228  [10]
 LDCM0028  Dobutamine HEK-293T 5.05  LDD0180  [4]
 LDCM0027  Dopamine HEK-293T 11.21  LDD0179  [4]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C61(1.01)  LDD1702  [3]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [6]
 LDCM0625  F8 Ramos C56(1.50)  LDD2187  [17]
 LDCM0572  Fragment10 Ramos C56(1.33)  LDD2189  [17]
 LDCM0573  Fragment11 Ramos C56(14.87)  LDD2190  [17]
 LDCM0574  Fragment12 Ramos C56(0.93)  LDD2191  [17]
 LDCM0575  Fragment13 Ramos C56(0.86)  LDD2192  [17]
 LDCM0576  Fragment14 Ramos C56(0.86)  LDD2193  [17]
 LDCM0579  Fragment20 Ramos C56(0.97)  LDD2194  [17]
 LDCM0580  Fragment21 Ramos C56(0.86)  LDD2195  [17]
 LDCM0582  Fragment23 Ramos C56(1.12)  LDD2196  [17]
 LDCM0578  Fragment27 Ramos C56(0.94)  LDD2197  [17]
 LDCM0586  Fragment28 Ramos C56(0.94)  LDD2198  [17]
 LDCM0588  Fragment30 Ramos C56(1.14)  LDD2199  [17]
 LDCM0589  Fragment31 Ramos C56(1.02)  LDD2200  [17]
 LDCM0590  Fragment32 Ramos C56(3.69)  LDD2201  [17]
 LDCM0468  Fragment33 HEK-293T C61(1.07)  LDD1066  [7]
 LDCM0596  Fragment38 Ramos C56(0.92)  LDD2203  [17]
 LDCM0566  Fragment4 Ramos C56(1.29)  LDD2184  [17]
 LDCM0427  Fragment51 HEK-293T C61(1.03)  LDD1025  [7]
 LDCM0610  Fragment52 Ramos C56(1.21)  LDD2204  [17]
 LDCM0614  Fragment56 Ramos C56(1.68)  LDD2205  [17]
 LDCM0569  Fragment7 Ramos C56(1.32)  LDD2186  [17]
 LDCM0571  Fragment9 Ramos C56(1.24)  LDD2188  [17]
 LDCM0022  KB02 Ramos C56(2.26)  LDD2182  [17]
 LDCM0023  KB03 MDA-MB-231 C61(1.22)  LDD1701  [3]
 LDCM0024  KB05 G361 C61(3.72)  LDD3311  [18]
 LDCM0030  Luteolin HEK-293T 11.45  LDD0182  [4]
 LDCM0109  NEM HeLa H136(0.00); H46(0.00)  LDD0227  [14]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C215(0.46)  LDD2109  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C215(0.93)  LDD2136  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C215(0.64)  LDD2140  [3]
 LDCM0627  NUDT7-COV-1 HEK-293T C56(0.93)  LDD2206  [19]
 LDCM0628  OTUB2-COV-1 HEK-293T C56(0.53)  LDD2207  [19]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
17-beta-hydroxysteroid dehydrogenase 14 (HSD17B14) Short-chain dehydrogenases/reductases (SDR) family Q9BPX1
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Major prion protein (PRNP) Prion family P04156
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA mismatch repair protein Mlh1 (MLH1) DNA mismatch repair MutL/HexB family P40692

The Drug(s) Related To This Target

Approved
Click To Hide/Show 5 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cisplatin Small molecular drug DB00515
Zinc . DB01593
Zinc Acetate . DB14487
Zinc Chloride . DB14533
Zinc Sulfate Unspecified Form . DB14548

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
13 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
14 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
15 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
16 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
17 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
18 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
19 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.