Details of the Target

General Information of Target

Target ID LDTP11293
Target Name Nucleoporin p58/p45 (NUP58)
Gene Name NUP58
Gene ID 9818
Synonyms
KIAA0410; NUPL1; Nucleoporin p58/p45; 58 kDa nucleoporin; Nucleoporin-like protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTLFHFGNCFALAYFPYFITYKCSGLSEYNAFWKCVQAGVTYLFVQLCKMLFLATFFPTW
EGGIYDFIGEFMKASVDVADLIGLNLVMSRNAGKGEYKIMVAALGWATAELIMSRCIPLW
VGARGIEFDWKYIQMSIDSNISLVHYIVASAQVWMITRYDLYHTFRPAVLLLMFLSVYKA
FVMETFVHLCSLGSWAALLARAVVTGLLALSTLALYVAVVNVHS
Target Bioclass
Transporter and channel
Family
NUP58 family
Subcellular location
Nucleus, nuclear pore complex
Function Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane.
Uniprot ID
Q9BVL2
Ensemble ID
ENST00000381718.8
HGNC ID
HGNC:20261

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CORL88 SNV: p.G597R DBIA    Probe Info 
HT115 SNV: p.R599I .
KMS11 SNV: p.G233R .
KYSE510 SNV: p.E408G .
LS180 Deletion: p.L200Ter .
OVK18 Deletion: p.A117del .
SW948 SNV: p.G25A .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DA-P2
 Probe Info  		7.18  LDD0348  [1]
STPyne
 Probe Info  		K288(8.33); K291(6.33)  LDD0277  [2]
Probe 1
 Probe Info  		Y339(8.07)  LDD3495  [3]
m-APA
 Probe Info  		11.47  LDD0403  [4]
BTD
 Probe Info  		C252(1.33)  LDD2089  [5]
AHL-Pu-1
 Probe Info  		C252(5.16)  LDD0170  [6]
DBIA
 Probe Info  		C252(1.14)  LDD0532  [7]
5E-2FA
 Probe Info  		N.A.  LDD2235  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [9]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [10]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [11]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [9]
NAIA_4
 Probe Info  		N.A.  LDD2226  [12]
NAIA_5
 Probe Info  		N.A.  LDD2224  [12]
IPM
 Probe Info  		N.A.  LDD0005  [13]
PPMS
 Probe Info  		N.A.  LDD0008  [13]
VSF
 Probe Info  		N.A.  LDD0007  [13]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [14]
Ox-W18
 Probe Info  		N.A.  LDD2175  [15]
Acrolein
 Probe Info  		N.A.  LDD0217  [16]
Methacrolein
 Probe Info  		N.A.  LDD0218  [16]
W1
 Probe Info  		N.A.  LDD0236  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C252(0.72)  LDD2142  [5]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C252(0.68)  LDD2112  [5]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C252(0.59)  LDD2095  [5]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C252(0.67)  LDD2130  [5]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C252(0.93)  LDD2117  [5]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C252(0.90)  LDD2103  [5]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C252(0.70)  LDD2132  [5]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C252(0.71)  LDD2131  [5]
 LDCM0025  4SU-RNA DM93 C252(5.16)  LDD0170  [6]
 LDCM0026  4SU-RNA+native RNA DM93 C252(2.12)  LDD0171  [6]
 LDCM0214  AC1 HEK-293T C252(0.96)  LDD1507  [18]
 LDCM0215  AC10 HCT 116 C252(1.14)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C252(0.71)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C252(0.68)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C252(0.66)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C252(1.01)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C252(0.67)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C252(0.77)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C252(0.92)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C252(0.89)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C252(0.60)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C252(0.69)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C252(1.14)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C252(0.77)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C252(0.71)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C252(0.79)  LDD0546  [7]
 LDCM0237  AC12 HCT 116 C252(1.09)  LDD0554  [7]
 LDCM0246  AC128 HCT 116 C252(1.20)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C252(0.85)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C252(1.03)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C252(1.02)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C252(1.11)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C252(1.14)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C252(1.07)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C252(1.13)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C252(1.07)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C252(1.04)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C252(1.02)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C252(1.18)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C252(1.00)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C252(1.27)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C252(1.17)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C252(1.03)  LDD0579  [7]
 LDCM0270  AC15 HCT 116 C252(1.00)  LDD0587  [7]
 LDCM0276  AC17 HEK-293T C252(0.99)  LDD1515  [18]
 LDCM0277  AC18 HEK-293T C252(1.05)  LDD1516  [18]
 LDCM0278  AC19 HEK-293T C252(0.89)  LDD1517  [18]
 LDCM0279  AC2 HEK-293T C252(1.06)  LDD1518  [18]
 LDCM0280  AC20 HEK-293T C252(0.94)  LDD1519  [18]
 LDCM0281  AC21 HEK-293T C252(0.96)  LDD1520  [18]
 LDCM0282  AC22 HEK-293T C252(0.92)  LDD1521  [18]
 LDCM0283  AC23 HEK-293T C252(1.09)  LDD1522  [18]
 LDCM0284  AC24 HEK-293T C252(0.98)  LDD1523  [18]
 LDCM0285  AC25 HEK-293T C252(0.89)  LDD1524  [18]
 LDCM0286  AC26 HEK-293T C252(1.05)  LDD1525  [18]
 LDCM0287  AC27 HEK-293T C252(0.94)  LDD1526  [18]
 LDCM0288  AC28 HEK-293T C252(0.94)  LDD1527  [18]
 LDCM0289  AC29 HEK-293T C252(0.96)  LDD1528  [18]
 LDCM0290  AC3 HEK-293T C252(0.93)  LDD1529  [18]
 LDCM0291  AC30 HEK-293T C252(0.95)  LDD1530  [18]
 LDCM0292  AC31 HEK-293T C252(1.06)  LDD1531  [18]
 LDCM0293  AC32 HEK-293T C252(0.98)  LDD1532  [18]
 LDCM0294  AC33 HEK-293T C252(0.90)  LDD1533  [18]
 LDCM0295  AC34 HEK-293T C252(1.06)  LDD1534  [18]
 LDCM0296  AC35 HEK-293T C252(0.90)  LDD1535  [18]
 LDCM0297  AC36 HEK-293T C252(0.90)  LDD1536  [18]
 LDCM0298  AC37 HEK-293T C252(1.00)  LDD1537  [18]
 LDCM0299  AC38 HEK-293T C252(0.97)  LDD1538  [18]
 LDCM0300  AC39 HEK-293T C252(1.14)  LDD1539  [18]
 LDCM0301  AC4 HEK-293T C252(0.93)  LDD1540  [18]
 LDCM0302  AC40 HEK-293T C252(0.98)  LDD1541  [18]
 LDCM0303  AC41 HEK-293T C252(0.95)  LDD1542  [18]
 LDCM0304  AC42 HEK-293T C252(1.08)  LDD1543  [18]
 LDCM0305  AC43 HEK-293T C252(0.99)  LDD1544  [18]
 LDCM0306  AC44 HEK-293T C252(1.01)  LDD1545  [18]
 LDCM0307  AC45 HEK-293T C252(1.00)  LDD1546  [18]
 LDCM0308  AC46 HEK-293T C252(0.97)  LDD1547  [18]
 LDCM0309  AC47 HEK-293T C252(1.04)  LDD1548  [18]
 LDCM0310  AC48 HEK-293T C252(1.09)  LDD1549  [18]
 LDCM0311  AC49 HEK-293T C252(0.94)  LDD1550  [18]
 LDCM0312  AC5 HEK-293T C252(1.00)  LDD1551  [18]
 LDCM0313  AC50 HEK-293T C252(1.12)  LDD1552  [18]
 LDCM0314  AC51 HEK-293T C252(0.98)  LDD1553  [18]
 LDCM0315  AC52 HEK-293T C252(1.01)  LDD1554  [18]
 LDCM0316  AC53 HEK-293T C252(1.06)  LDD1555  [18]
 LDCM0317  AC54 HEK-293T C252(0.98)  LDD1556  [18]
 LDCM0318  AC55 HEK-293T C252(1.11)  LDD1557  [18]
 LDCM0319  AC56 HEK-293T C252(1.00)  LDD1558  [18]
 LDCM0320  AC57 HCT 116 C252(1.04)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C252(1.11)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C252(1.14)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C252(1.16)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C252(1.02)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C252(0.98)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C252(1.09)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C252(0.97)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C252(1.23)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C252(1.16)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C252(0.97)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C252(1.16)  LDD0648  [7]
 LDCM0334  AC7 HCT 116 C252(1.19)  LDD0651  [7]
 LDCM0345  AC8 HCT 116 C252(0.96)  LDD0662  [7]
 LDCM0365  AC98 HCT 116 C252(0.89)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C252(0.64)  LDD0683  [7]
 LDCM0520  AKOS000195272 MDA-MB-231 C252(0.79)  LDD2113  [5]
 LDCM0248  AKOS034007472 HCT 116 C252(0.98)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C252(1.18)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C252(1.07)  LDD0592  [7]
 LDCM0156  Aniline NCI-H1299 11.47  LDD0403  [4]
 LDCM0498  BS-3668 MDA-MB-231 C252(0.64)  LDD2091  [5]
 LDCM0108  Chloroacetamide HeLa C252(0.00); H337(0.00)  LDD0222  [16]
 LDCM0367  CL1 HCT 116 C252(0.85)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C252(0.94)  LDD0685  [7]
 LDCM0369  CL100 HEK-293T C252(0.94)  LDD1573  [18]
 LDCM0370  CL101 HCT 116 C252(1.00)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C252(0.99)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C252(1.00)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C252(1.05)  LDD0690  [7]
 LDCM0374  CL105 HEK-293T C252(0.91)  LDD1578  [18]
 LDCM0375  CL106 HEK-293T C252(0.93)  LDD1579  [18]
 LDCM0376  CL107 HEK-293T C252(1.07)  LDD1580  [18]
 LDCM0377  CL108 HEK-293T C252(1.00)  LDD1581  [18]
 LDCM0378  CL109 HEK-293T C252(1.02)  LDD1582  [18]
 LDCM0379  CL11 HCT 116 C252(1.18)  LDD0696  [7]
 LDCM0380  CL110 HEK-293T C252(0.98)  LDD1584  [18]
 LDCM0381  CL111 HEK-293T C252(1.08)  LDD1585  [18]
 LDCM0382  CL112 HEK-293T C252(1.03)  LDD1586  [18]
 LDCM0383  CL113 HEK-293T C252(0.97)  LDD1587  [18]
 LDCM0384  CL114 HEK-293T C252(0.86)  LDD1588  [18]
 LDCM0385  CL115 HEK-293T C252(1.01)  LDD1589  [18]
 LDCM0386  CL116 HEK-293T C252(0.98)  LDD1590  [18]
 LDCM0387  CL117 HEK-293T C252(1.01)  LDD1591  [18]
 LDCM0388  CL118 HEK-293T C252(0.91)  LDD1592  [18]
 LDCM0389  CL119 HEK-293T C252(1.02)  LDD1593  [18]
 LDCM0390  CL12 HCT 116 C252(1.20)  LDD0707  [7]
 LDCM0391  CL120 HEK-293T C252(0.98)  LDD1595  [18]
 LDCM0392  CL121 HEK-293T C252(0.96)  LDD1596  [18]
 LDCM0393  CL122 HEK-293T C252(1.06)  LDD1597  [18]
 LDCM0394  CL123 HEK-293T C252(1.09)  LDD1598  [18]
 LDCM0395  CL124 HEK-293T C252(1.06)  LDD1599  [18]
 LDCM0396  CL125 HCT 116 C252(0.81)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C252(0.84)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C252(1.03)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C252(1.09)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C252(1.14)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C252(0.94)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C252(0.86)  LDD0719  [7]
 LDCM0403  CL16 HEK-293T C252(1.06)  LDD1607  [18]
 LDCM0404  CL17 HEK-293T C252(1.01)  LDD1608  [18]
 LDCM0405  CL18 HEK-293T C252(0.92)  LDD1609  [18]
 LDCM0406  CL19 HEK-293T C252(1.06)  LDD1610  [18]
 LDCM0407  CL2 HCT 116 C252(0.90)  LDD0724  [7]
 LDCM0408  CL20 HEK-293T C252(1.06)  LDD1612  [18]
 LDCM0409  CL21 HEK-293T C252(0.81)  LDD1613  [18]
 LDCM0410  CL22 HEK-293T C252(1.04)  LDD1614  [18]
 LDCM0411  CL23 HEK-293T C252(0.67)  LDD1615  [18]
 LDCM0412  CL24 HEK-293T C252(1.12)  LDD1616  [18]
 LDCM0413  CL25 HEK-293T C252(1.21)  LDD1617  [18]
 LDCM0414  CL26 HEK-293T C252(0.90)  LDD1618  [18]
 LDCM0415  CL27 HEK-293T C252(0.89)  LDD1619  [18]
 LDCM0416  CL28 HEK-293T C252(1.06)  LDD1620  [18]
 LDCM0417  CL29 HEK-293T C252(1.03)  LDD1621  [18]
 LDCM0418  CL3 HCT 116 C252(0.86)  LDD0735  [7]
 LDCM0419  CL30 HEK-293T C252(1.01)  LDD1623  [18]
 LDCM0420  CL31 HCT 116 C252(1.04)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C252(0.90)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C252(1.04)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C252(0.93)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C252(0.91)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C252(0.96)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C252(1.01)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C252(1.06)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C252(0.88)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C252(0.92)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C252(1.03)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C252(0.99)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C252(0.96)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C252(1.11)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C252(0.96)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C252(1.10)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C252(0.78)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C252(0.95)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C252(0.92)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C252(1.07)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C252(0.81)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C252(1.07)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C252(1.10)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C252(0.83)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C252(1.00)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C252(1.05)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C252(0.93)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C252(0.85)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C252(0.70)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C252(0.89)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C252(1.02)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C252(0.90)  LDD0769  [7]
 LDCM0453  CL61 HEK-293T C252(0.94)  LDD1656  [18]
 LDCM0454  CL62 HEK-293T C252(0.97)  LDD1657  [18]
 LDCM0455  CL63 HEK-293T C252(1.01)  LDD1658  [18]
 LDCM0456  CL64 HEK-293T C252(1.01)  LDD1659  [18]
 LDCM0457  CL65 HEK-293T C252(1.01)  LDD1660  [18]
 LDCM0458  CL66 HEK-293T C252(0.94)  LDD1661  [18]
 LDCM0459  CL67 HEK-293T C252(0.96)  LDD1662  [18]
 LDCM0460  CL68 HEK-293T C252(1.13)  LDD1663  [18]
 LDCM0461  CL69 HEK-293T C252(0.90)  LDD1664  [18]
 LDCM0462  CL7 HCT 116 C252(0.97)  LDD0779  [7]
 LDCM0463  CL70 HEK-293T C252(1.02)  LDD1666  [18]
 LDCM0464  CL71 HEK-293T C252(0.64)  LDD1667  [18]
 LDCM0465  CL72 HEK-293T C252(1.12)  LDD1668  [18]
 LDCM0466  CL73 HEK-293T C252(0.98)  LDD1669  [18]
 LDCM0467  CL74 HEK-293T C252(0.94)  LDD1670  [18]
 LDCM0469  CL76 HEK-293T C252(0.91)  LDD1672  [18]
 LDCM0470  CL77 HEK-293T C252(1.00)  LDD1673  [18]
 LDCM0471  CL78 HEK-293T C252(1.01)  LDD1674  [18]
 LDCM0472  CL79 HEK-293T C252(1.04)  LDD1675  [18]
 LDCM0473  CL8 HCT 116 C252(1.04)  LDD0790  [7]
 LDCM0474  CL80 HEK-293T C252(1.09)  LDD1677  [18]
 LDCM0475  CL81 HEK-293T C252(0.82)  LDD1678  [18]
 LDCM0476  CL82 HEK-293T C252(0.98)  LDD1679  [18]
 LDCM0477  CL83 HEK-293T C252(0.71)  LDD1680  [18]
 LDCM0478  CL84 HEK-293T C252(1.03)  LDD1681  [18]
 LDCM0479  CL85 HEK-293T C252(0.94)  LDD1682  [18]
 LDCM0480  CL86 HEK-293T C252(0.91)  LDD1683  [18]
 LDCM0481  CL87 HEK-293T C252(0.91)  LDD1684  [18]
 LDCM0482  CL88 HEK-293T C252(1.02)  LDD1685  [18]
 LDCM0483  CL89 HEK-293T C252(1.00)  LDD1686  [18]
 LDCM0484  CL9 HCT 116 C252(1.01)  LDD0801  [7]
 LDCM0485  CL90 HEK-293T C252(1.12)  LDD1688  [18]
 LDCM0486  CL91 HEK-293T C252(1.01)  LDD1689  [18]
 LDCM0487  CL92 HEK-293T C252(1.08)  LDD1690  [18]
 LDCM0488  CL93 HEK-293T C252(0.97)  LDD1691  [18]
 LDCM0489  CL94 HEK-293T C252(0.97)  LDD1692  [18]
 LDCM0490  CL95 HEK-293T C252(0.87)  LDD1693  [18]
 LDCM0491  CL96 HEK-293T C252(0.93)  LDD1694  [18]
 LDCM0492  CL97 HEK-293T C252(1.02)  LDD1695  [18]
 LDCM0493  CL98 HEK-293T C252(0.94)  LDD1696  [18]
 LDCM0494  CL99 HEK-293T C252(0.84)  LDD1697  [18]
 LDCM0495  E2913 HEK-293T C252(0.93)  LDD1698  [18]
 LDCM0625  F8 Ramos C252(2.94)  LDD2187  [19]
 LDCM0572  Fragment10 Ramos C252(1.78)  LDD2189  [19]
 LDCM0574  Fragment12 Ramos C252(1.06)  LDD2191  [19]
 LDCM0576  Fragment14 Ramos C252(2.32)  LDD2193  [19]
 LDCM0579  Fragment20 Ramos C252(1.40)  LDD2194  [19]
 LDCM0580  Fragment21 Ramos C252(1.20)  LDD2195  [19]
 LDCM0582  Fragment23 Ramos C252(1.06)  LDD2196  [19]
 LDCM0578  Fragment27 Ramos C252(0.44)  LDD2197  [19]
 LDCM0588  Fragment30 Ramos C252(0.91)  LDD2199  [19]
 LDCM0590  Fragment32 Ramos C252(1.96)  LDD2201  [19]
 LDCM0468  Fragment33 HEK-293T C252(0.88)  LDD1671  [18]
 LDCM0596  Fragment38 Ramos C252(1.85)  LDD2203  [19]
 LDCM0566  Fragment4 Ramos C252(4.83)  LDD2184  [19]
 LDCM0427  Fragment51 HCT 116 C252(0.86)  LDD0744  [7]
 LDCM0610  Fragment52 Ramos C252(0.35)  LDD2204  [19]
 LDCM0614  Fragment56 Ramos C252(7.98)  LDD2205  [19]
 LDCM0569  Fragment7 Ramos C252(2.23)  LDD2186  [19]
 LDCM0571  Fragment9 Ramos C252(4.91)  LDD2188  [19]
 LDCM0107  IAA HeLa N.A.  LDD0221  [16]
 LDCM0022  KB02 HEK-293T C252(0.95)  LDD1492  [18]
 LDCM0023  KB03 HEK-293T C252(1.01)  LDD1497  [18]
 LDCM0024  KB05 HMCB C252(2.37)  LDD3312  [20]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C252(0.57)  LDD2102  [5]
 LDCM0109  NEM HeLa N.A.  LDD0223  [16]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C252(1.33)  LDD2089  [5]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C252(0.72)  LDD2098  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C252(1.03)  LDD2099  [5]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C252(0.55)  LDD2100  [5]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C252(1.04)  LDD2101  [5]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C252(0.78)  LDD2105  [5]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C252(0.34)  LDD2106  [5]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C252(0.51)  LDD2108  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C252(0.94)  LDD2109  [5]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C252(0.74)  LDD2110  [5]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C252(0.37)  LDD2114  [5]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C252(0.60)  LDD2115  [5]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C252(0.98)  LDD2120  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C252(0.88)  LDD2123  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C252(1.03)  LDD2125  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C252(1.09)  LDD2127  [5]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C252(1.06)  LDD2128  [5]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C252(0.87)  LDD2134  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C252(1.02)  LDD2137  [5]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C252(0.54)  LDD2141  [5]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C252(0.80)  LDD2143  [5]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C252(1.55)  LDD2147  [5]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C252(0.84)  LDD2148  [5]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C252(0.44)  LDD2150  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
26S proteasome regulatory subunit 7 (PSMC2) AAA ATPase family P35998
Anterior gradient protein 2 homolog (AGR2) AGR family O95994
COP9 signalosome complex subunit 4 (COPS4) CSN4 family Q9BT78
Methylthioribose-1-phosphate isomerase (MRI1) EIF-2B alpha/beta/delta subunits family Q9BV20
Eukaryotic translation initiation factor 3 subunit F (EIF3F) EIF-3 subunit F family O00303
Amine oxidase [flavin-containing] B (MAOB) Flavin monoamine oxidase family P27338
Mediator of RNA polymerase II transcription subunit 21 (MED21) Mediator complex subunit 21 family Q13503
Dihydropyrimidinase (DPYS) Hydantoinase/dihydropyrimidinase family Q14117
Transcriptional adapter 3 (TADA3) NGG1 family O75528
Phosphatidylinositol N-acetylglucosaminyltransferase subunit P (PIGP) PIGP family P57054
Protein-arginine deiminase type-3 (PADI3) Protein arginine deiminase family Q9ULW8
E3 ubiquitin-protein ligase RNF31 (RNF31) RBR family Q96EP0
Threonylcarbamoyl-AMP synthase (YRDC) SUA5 family Q86U90
Ubiquitin-conjugating enzyme E2 A (UBE2A) Ubiquitin-conjugating enzyme family P49459
Methyltransferase-like protein 27 (METTL27) . Q8N6F8
Transporter and channel
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ATPase inhibitor, mitochondrial (ATP5IF1) ATPase inhibitor family Q9UII2
Cytochrome c oxidase subunit 7A1, mitochondrial (COX7A1) Cytochrome c oxidase VIIa family P24310
Gastrokine-1 (GKN1) Gastrokine family Q9NS71
Huntingtin (HTT) Huntingtin family P42858
Nuclear pore glycoprotein p62 (NUP62) Nucleoporin NSP1/NUP62 family P37198
Nucleoporin p54 (NUP54) NUP54 family Q7Z3B4
Syntaxin-19 (STX19) Syntaxin family Q8N4C7
Transcription factor
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ETS domain-containing protein Elk-3 (ELK3) ETS family P41970
Krueppel-like factor 3 (KLF3) Krueppel C2H2-type zinc-finger protein family P57682
Krueppel-like factor 5 (KLF5) Krueppel C2H2-type zinc-finger protein family Q13887
Visual system homeobox 2 (VSX2) Paired homeobox family P58304
Homeobox protein PKNOX1 (PKNOX1) TALE/MEIS homeobox family P55347
Homeobox protein PKNOX2 (PKNOX2) TALE/MEIS homeobox family Q96KN3
Signal transducer and activator of transcription 4 (STAT4) Transcription factor STAT family Q14765
B-cell lymphoma 3 protein (BCL3) . P20749
Neurogenic differentiation factor 1 (NEUROD1) . Q13562
Other
Click To Hide/Show 46 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ABI gene family member 3 (ABI3) ABI family Q9P2A4
Ameloblastin (AMBN) Ameloblastin family Q9NP70
Protein BRICK1 (BRK1) BRK1 family Q8WUW1
Conserved oligomeric Golgi complex subunit 6 (COG6) COG6 family Q9Y2V7
Conserved oligomeric Golgi complex subunit 8 (COG8) COG8 family Q96MW5
DAP3-binding cell death enhancer 1 (DELE1) DELE1 family Q14154
Endoplasmic reticulum-Golgi intermediate compartment protein 1 (ERGIC1) ERGIC family Q969X5
DNA replication complex GINS protein PSF3 (GINS3) GINS3/PSF3 family Q9BRX5
HAUS augmin-like complex subunit 1 (HAUS1) HAUS1 family Q96CS2
HAUS augmin-like complex subunit 7 (HAUS7) HAUS7 family Q99871
Keratin, type I cuticular Ha3-II (KRT33B) Intermediate filament family Q14525
Keratin, type I cytoskeletal 27 (KRT27) Intermediate filament family Q7Z3Y8
Keratin, type I cytoskeletal 28 (KRT28) Intermediate filament family Q7Z3Y7
Kinesin light chain 3 (KLC3) Kinesin light chain family Q6P597
Metallothionein-2 (MT2A) Type 1 family P02795
Protein Mis18-alpha (MIS18A) Mis18 family Q9NYP9
Protein Mis18-beta (OIP5) Mis18 family O43482
Negative elongation factor C/D (NELFCD) NELF-D family Q8IXH7
Polyadenylate-binding protein-interacting protein 2 (PAIP2) PAIP2 family Q9BPZ3
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (SMARCD1) SMARCD family Q96GM5
Charged multivesicular body protein 7 (CHMP7) SNF7 family Q8WUX9
Pre-mRNA-splicing factor SPF27 (BCAS2) SPF27 family O75934
Signal transducing adapter molecule 2 (STAM2) STAM family O75886
CST complex subunit TEN1 (TEN1) TEN1 family Q86WV5
Tetraspanin-2 (TSPAN2) Tetraspanin (TM4SF) family O60636
Translin-associated protein X (TSNAX) Translin family Q99598
TSSK6-activating co-chaperone protein (TSACC) TSACC family Q96A04
Vacuolar protein sorting-associated protein 37A (VPS37A) VPS37 family Q8NEZ2
Break repair meiotic recombinase recruitment factor 1 (BRME1) . Q0VDD7
Bromo adjacent homology domain-containing 1 protein (BAHD1) . Q8TBE0
Centromere protein R (ITGB3BP) . Q13352
Fanconi anemia group G protein (FANCG) . O15287
Galectin-9C (LGALS9C) . Q6DKI2
Kinetochore-associated protein DSN1 homolog (DSN1) . Q9H410
Leucine-rich repeat-containing protein 61 (LRRC61) . Q9BV99
Polyamine-modulated factor 1 (PMF1) . Q6P1K2
Required for excision 1-B domain-containing protein (REX1BD) . Q96EN9
Spermatogenesis-associated protein 12 (SPATA12) . Q7Z6I5
Synaptonemal complex central element protein 3 (SYCE3) . A1L190
Testis-expressed protein 12 (TEX12) . Q9BXU0
Tetratricopeptide repeat protein 33 (TTC33) . Q6PID6
TNF receptor-associated factor 1 (TRAF1) . Q13077
Ubiquilin-2 (UBQLN2) . Q9UHD9
Ubiquilin-3 (UBQLN3) . Q9H347
Uncharacterized protein KIAA0408 (KIAA0408) . Q6ZU52
ZW10 interactor (ZWINT) . O95229

References

1 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
15 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
20 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840