Details of the Target

General Information of Target

Target ID LDTP14426
Target Name TRAF-type zinc finger domain-containing protein 1 (TRAFD1)
Gene Name TRAFD1
Gene ID 10906
Synonyms
FLN29; TRAF-type zinc finger domain-containing protein 1; Protein FLN29
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEGKRQLEKRDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREV
AQRTSEGAMHEKLIHELEEERHLRLQSEKRLQEVTLESERNRIQMRSLQQQFSRMEETVR
NLLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSSTDEGKE
KTKLLLERLKALEAENSALALENENQREQYERCLDEVANQVVQALLTQKDLREECVKLKT
RVFDLEQQNRTLSILFQQRVRPTSDLLLQKLHSRLLDLSSGDLLSEVERNRSLTQSRTDA
EVHEHQLNTKSALKCPGLGAVIPGHLCPRNSYSSSSELSLSSTCSEYSSGSSYTWHDGKN
LRKRQSSQNWDKRLSIDSSLPSGFASPTNELPPTRIKESHILEGLRKLQKRKVLLEPPSV
ITKWGYKDCMNSNEGIYSPGIKSSSLKEYPPCKTADLGSPCKEPHKTFVYDLDSHVDADD
DPSTLALLQAVPNQSCRPHGSKLTHSVSDSLFGWETNRKHFLEGTSSVYPKERPEKLTSC
ASSCPLEMKLCPSVQTPQVQRERGPQGQGHGRMALNLQLSDTDDNETFDELHIESSDEKS
PSDVSLAADTDKSVENLDVLVGFGKSLCGSPEEEEKQVPIPSETRPKTFSFIKQQRVVKR
TSSEECVTVIFDAEDGEPIEFSSHQTGVVTVTRNEISINSTPAGPKAEHTELLPQGIACL
QPRAAARDYTFFKRSEEDTEKNIPKDNVDNVPRVSTESFSSRTVTQNPQQQKLVKPTHNI
SCQSNSRSSAPMGIYQKQNLTKIPPRGKSSPQKSKLMEPEATTLLPSSGLVTLEKSPALA
PGKLSRFMKTESSGPLFELRSDPHIPKHSAQLPHSSRMPSRRDWVQCPKSQTPGSRSRPA
IESSDSGEPPTRDEHCGSGPEAGVKSPSPPPPPGRSVSLLARPSYDYSPAPSSTKSETRV
PSETARTPFKSPLLKGISAPVISSNPATTEVQRKKPSVAFKKPIFTHPMPSPEAVIQTRC
PAHAPSSSFTVMALGPPKVSPKRGVPKTSPRQTLGTPQRDIGLQTPRISPSTHEPLEMTS
SKSVSPGRKGQLNDSASTPPKPSFLGVNESPSSQVSSSSSSSSPAKSHNSPHGCQSAHEK
GLKTRLPVGLKVLMKSPQLLRKSSTVPGKHEKDSLNEASKSSVAVNKSKPEDSKNPASME
ITAGERNVTLPDSQAQGSLADGLPLETALQEPLESSIPGSDGRDGVDNRSMRRSLSSSKP
HLKPALGMNGAKARSHSFSTHSGDKPSTPPIEGSGKVRTQIITNTAERGNSLTRQNSSTE
SSPNKAPSAPMLESLPSVGRPSGHPSSGKGSLGSSGSFSSQHGSPSKLPLRIPPKSEGLL
IPPGKEDQQAFTQGECPSANVAVLGEPGSDRRSCPPTPTDCPEALQSPGRTQHPSTFETS
STSKLETSGRHPDASATATDAVSSEAPLSPTIEEKVMLCIQENVEKGQVQTKPTSVEAKQ
KPGPSFASWFGFRKSRLPALSSRKMDISKTKVEKKDAKVLGFGNRQLKSERKKEKKKPEL
QCETENELIKDTKSADNPDGGLQSKNNRRTPQDIYNQLKIEPRNRHSPVACSTKDTFMTE
LLNRVDKKAAPQTESGSSNASCRNVLKGSSQGSCLIGSSISTQGNHKKNMKIKADMEVPK
DSLVKEANENLQEDEDDAVADSVFQSHIIESNCQMRTLDSGIGTFPLPDSGNRSTGRYLC
QPDSPEDAEPLLPLQSALSAVSSMRAQTLEREVPSSTDGQRPADSAIVHSTSDPIMTARG
MRPLQSRLPKPASSGKVSSQKQNEAEPRPQTCSSFGYAEDPMASQPLPDWGSEVAATGTQ
DKAPRMCTYSASGGSNSDSDLDYGDNGFGAGRGQLVKALKSAAPEIETT
Target Bioclass
Other
Function
Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3.
Uniprot ID
O14545
Ensemble ID
ENST00000257604.9
HGNC ID
HGNC:24808

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
8305C SNV: p.K76R DBIA    Probe Info 
CHL1 SNV: p.P416S DBIA    Probe Info 
HCT15 SNV: p.P419H .
JURKAT SNV: p.Q343Ter Compound 10    Probe Info 
MDAMB468 SNV: p.F383S DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DA-P2
 Probe Info  		4.08  LDD0348  [1]
BTD
 Probe Info  		C135(1.06)  LDD2093  [2]
DA-P3
 Probe Info  		4.50  LDD0182  [1]
AHL-Pu-1
 Probe Info  		C267(2.08)  LDD0169  [3]
HHS-465
 Probe Info  		Y558(9.86)  LDD2237  [4]
DBIA
 Probe Info  		C476(1.03); C482(1.03); C116(0.88); C119(0.88)  LDD0078  [5]
5E-2FA
 Probe Info  		H273(0.00); H510(0.00); H399(0.00)  LDD2235  [6]
m-APA
 Probe Info  		H273(0.00); H510(0.00); H399(0.00)  LDD2231  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		C267(0.00); C109(0.00)  LDD0037  [7]
NAIA_4
 Probe Info  		N.A.  LDD2226  [8]
TFBX
 Probe Info  		N.A.  LDD0027  [9]
Compound 10
 Probe Info  		N.A.  LDD2216  [10]
Compound 11
 Probe Info  		N.A.  LDD2213  [10]
IPM
 Probe Info  		C267(0.00); C482(0.00)  LDD0005  [11]
SF
 Probe Info  		N.A.  LDD0028  [12]
VSF
 Probe Info  		C476(0.00); C482(0.00)  LDD0007  [11]
Phosphinate-6
 Probe Info  		C60(0.00); C482(0.00); C476(0.00)  LDD0018  [13]
Acrolein
 Probe Info  		N.A.  LDD0217  [14]
Methacrolein
 Probe Info  		N.A.  LDD0218  [14]
NAIA_5
 Probe Info  		C267(0.00); C66(0.00); C32(0.00); C83(0.00)  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C267(2.08)  LDD0169  [3]
 LDCM0561  Abegg_cp(-)-10 HeLa C267(2.93)  LDD0312  [9]
 LDCM0214  AC1 HCT 116 C476(0.69); C482(0.69); C267(0.96)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C267(1.17); C90(0.81); C93(0.81)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C476(0.93); C482(0.93)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C476(0.84); C482(0.84)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C476(0.77); C482(0.77)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C476(1.01); C482(1.01)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C476(1.04); C482(1.04)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C476(1.47); C482(1.47)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C476(1.04); C482(1.04)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C476(0.87); C482(0.87)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C476(0.61); C482(0.61)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C476(0.75); C482(0.75)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C267(1.34); C90(0.99); C93(0.99)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C476(1.12); C482(1.12)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C476(1.31); C482(1.31)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C476(0.99); C482(0.99)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C476(1.19); C482(1.19)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C476(1.76); C482(1.76)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C476(1.17); C482(1.17)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C476(1.92); C482(1.92)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C476(1.29); C482(1.29)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C476(0.86); C482(0.86)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C476(1.28); C482(1.28)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C267(1.01); C90(0.88); C93(0.88)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C476(1.56); C482(1.56)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C476(1.14); C482(1.14)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C476(1.13); C482(1.13)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C476(1.01); C482(1.01)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C476(1.46); C482(1.46)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C476(1.26); C482(1.26)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C476(2.45); C482(2.45)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C476(2.26); C482(2.26)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C476(1.00); C482(1.00)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C476(1.21); C482(1.21)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C476(0.94); C482(0.94)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C476(1.62); C482(1.62)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C476(0.40); C482(0.40)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C476(0.55); C482(0.55)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C476(0.77); C482(0.77)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C476(0.49); C482(0.49)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C476(0.60); C482(0.60)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C476(0.41); C482(0.41)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C476(0.45); C482(0.45)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C476(0.53); C482(0.53)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C267(1.00); C90(0.86); C93(0.86)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C476(0.56); C482(0.56)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C476(0.49); C482(0.49)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C476(0.39); C482(0.39)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C476(1.25); C482(1.25)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C476(2.26); C482(2.26)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C476(1.29); C482(1.29)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C476(1.61); C482(1.61)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C476(1.73); C482(1.73)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C476(1.96); C482(1.96)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C476(1.63); C482(1.63)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C90(0.81); C93(0.81); C267(1.00)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C476(1.31); C482(1.31)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C476(2.19); C482(2.19)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C476(2.33); C482(2.33)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C476(4.81); C482(4.81)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C476(2.81); C482(2.81)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C476(2.88); C482(2.88)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C476(2.55); C482(2.55)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C476(3.39); C482(3.39)  LDD2161  [5]
 LDCM0276  AC17 HEK-293T C39(1.12); C42(1.12); C90(0.77); C93(0.77)  LDD0874  [5]
 LDCM0277  AC18 HEK-293T C39(1.10); C42(1.10); C90(1.02); C93(1.02)  LDD0875  [5]
 LDCM0278  AC19 HEK-293T C39(1.10); C42(1.10); C90(1.10); C93(1.10)  LDD0876  [5]
 LDCM0279  AC2 HCT 116 C476(0.64); C482(0.64); C267(0.96)  LDD0596  [5]
 LDCM0280  AC20 HEK-293T C39(1.48); C42(1.48); C90(0.94); C93(0.94)  LDD0878  [5]
 LDCM0281  AC21 HEK-293T C39(1.23); C42(1.23); C90(1.09); C93(1.09)  LDD0879  [5]
 LDCM0282  AC22 HEK-293T C39(1.25); C42(1.25); C90(0.81); C93(0.81)  LDD0880  [5]
 LDCM0283  AC23 HEK-293T C39(1.21); C42(1.21); C90(0.58); C93(0.58)  LDD0881  [5]
 LDCM0284  AC24 HEK-293T C39(1.18); C42(1.18); C90(1.06); C93(1.06)  LDD0882  [5]
 LDCM0285  AC25 HEK-293T C116(0.83); C119(0.83); C39(1.62); C42(1.62)  LDD0883  [5]
 LDCM0286  AC26 HEK-293T C116(0.89); C119(0.89); C39(1.68); C42(1.68)  LDD0884  [5]
 LDCM0287  AC27 HEK-293T C116(0.84); C119(0.84); C39(1.41); C42(1.41)  LDD0885  [5]
 LDCM0288  AC28 HEK-293T C116(1.02); C119(1.02); C39(1.49); C42(1.49)  LDD0886  [5]
 LDCM0289  AC29 HEK-293T C116(0.82); C119(0.82); C39(1.62); C42(1.62)  LDD0887  [5]
 LDCM0290  AC3 HCT 116 C476(0.42); C482(0.42); C267(1.14)  LDD0607  [5]
 LDCM0291  AC30 HEK-293T C116(0.84); C119(0.84); C39(1.71); C42(1.71)  LDD0889  [5]
 LDCM0292  AC31 HEK-293T C116(0.84); C119(0.84); C39(1.68); C42(1.68)  LDD0890  [5]
 LDCM0293  AC32 HEK-293T C116(0.87); C119(0.87); C39(1.58); C42(1.58)  LDD0891  [5]
 LDCM0294  AC33 HEK-293T C116(0.86); C119(0.86); C39(1.41); C42(1.41)  LDD0892  [5]
 LDCM0295  AC34 HEK-293T C116(0.88); C119(0.88); C39(1.99); C42(1.99)  LDD0893  [5]
 LDCM0296  AC35 HEK-293T C267(1.05); C39(0.87); C42(0.87)  LDD0894  [5]
 LDCM0297  AC36 HEK-293T C267(0.94); C39(1.15); C42(1.15)  LDD0895  [5]
 LDCM0298  AC37 HEK-293T C267(1.07); C39(0.82); C42(0.82)  LDD0896  [5]
 LDCM0299  AC38 HEK-293T C267(1.02); C39(1.03); C42(1.03)  LDD0897  [5]
 LDCM0300  AC39 HEK-293T C267(1.20); C39(0.98); C42(0.98)  LDD0898  [5]
 LDCM0301  AC4 HCT 116 C476(0.38); C482(0.38); C267(0.82)  LDD0618  [5]
 LDCM0302  AC40 HEK-293T C267(1.31); C39(0.96); C42(0.96)  LDD0900  [5]
 LDCM0303  AC41 HEK-293T C267(0.99); C39(1.02); C42(1.02)  LDD0901  [5]
 LDCM0304  AC42 HEK-293T C267(0.94); C39(1.13); C42(1.13)  LDD0902  [5]
 LDCM0305  AC43 HEK-293T C267(0.97); C39(1.06); C42(1.06)  LDD0903  [5]
 LDCM0306  AC44 HEK-293T C267(0.97); C39(0.95); C42(0.95)  LDD0904  [5]
 LDCM0307  AC45 HEK-293T C267(1.04); C39(1.05); C42(1.05)  LDD0905  [5]
 LDCM0308  AC46 HCT 116 C267(1.00)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C267(1.00)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C267(0.89)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C267(0.84)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C476(0.41); C482(0.41); C267(0.82)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C267(0.86)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C267(0.97)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C267(0.84)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C267(0.91)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C267(1.02)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C267(1.07)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C267(1.28)  LDD0636  [5]
 LDCM0320  AC57 HEK-293T C116(0.93); C119(0.93); C39(0.89); C42(0.89)  LDD0918  [5]
 LDCM0321  AC58 HEK-293T C116(0.89); C119(0.89); C39(0.97); C42(0.97)  LDD0919  [5]
 LDCM0322  AC59 HEK-293T C116(0.82); C119(0.82); C39(0.84); C42(0.84)  LDD0920  [5]
 LDCM0323  AC6 HCT 116 C90(0.92); C93(0.92); C267(0.98)  LDD0640  [5]
 LDCM0324  AC60 HEK-293T C116(1.68); C119(1.68); C39(1.13); C42(1.13)  LDD0922  [5]
 LDCM0325  AC61 HEK-293T C116(1.03); C119(1.03); C39(0.86); C42(0.86)  LDD0923  [5]
 LDCM0326  AC62 HEK-293T C116(0.91); C119(0.91); C39(0.91); C42(0.91)  LDD0924  [5]
 LDCM0327  AC63 HEK-293T C116(0.94); C119(0.94); C39(1.04); C42(1.04)  LDD0925  [5]
 LDCM0328  AC64 HEK-293T C116(0.87); C119(0.87); C39(0.99); C42(0.99)  LDD0926  [5]
 LDCM0329  AC65 HEK-293T C116(1.08); C119(1.08); C39(0.99); C42(0.99)  LDD0927  [5]
 LDCM0330  AC66 HEK-293T C116(0.79); C119(0.79); C39(0.86); C42(0.86)  LDD0928  [5]
 LDCM0331  AC67 HEK-293T C116(0.90); C119(0.90); C39(1.01); C42(1.01)  LDD0929  [5]
 LDCM0332  AC68 HCT 116 C476(0.71); C482(0.71)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C476(1.13); C482(1.13)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C90(0.92); C93(0.92); C267(0.99)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C476(1.04); C482(1.04)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C476(0.54); C482(0.54)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C476(1.82); C482(1.82)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C476(1.93); C482(1.93)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C476(1.41); C482(1.41)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C476(3.07); C482(3.07)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C476(0.99); C482(0.99)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C476(1.33); C482(1.33)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C476(1.43); C482(1.43)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C476(0.82); C482(0.82)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C90(0.94); C93(0.94); C267(0.97)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C476(1.81); C482(1.81)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C476(0.94); C482(0.94)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C476(3.09); C482(3.09)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C90(0.92); C93(0.92); C476(2.01); C482(2.01)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C90(1.12); C93(1.12); C476(1.60); C482(1.60)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C476(1.05); C482(1.05); C90(1.14); C93(1.14)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C90(0.99); C93(0.99); C476(1.36); C482(1.36)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C90(0.74); C93(0.74); C476(1.63); C482(1.63)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C90(0.85); C93(0.85); C476(2.04); C482(2.04)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C90(0.79); C93(0.79); C476(3.73); C482(3.73)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C476(0.70); C482(0.70); C90(0.98); C93(0.98)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C90(1.13); C93(1.13); C476(3.71); C482(3.71)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C90(0.89); C93(0.89); C476(3.93); C482(3.93)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C90(0.96); C93(0.96); C476(2.32); C482(2.32)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C90(1.10); C93(1.10); C476(1.77); C482(1.77)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C90(0.97); C93(0.97); C476(2.48); C482(2.48)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C90(0.99); C93(0.99); C476(5.50); C482(5.50)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C90(0.97); C93(0.97); C476(2.47); C482(2.47)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C476(2.15); C482(2.15)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C476(0.64); C482(0.64)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C267(1.07); C90(0.84); C93(0.84)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C90(0.86); C93(0.86); C267(1.41)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C90(0.80); C93(0.80); C267(1.12)  LDD0592  [5]
 LDCM0020  ARS-1620 HCC44 C476(1.03); C482(1.03); C116(0.88); C119(0.88)  LDD0078  [5]
 LDCM0108  Chloroacetamide HeLa C109(0.00); C267(0.00)  LDD0222  [14]
 LDCM0632  CL-Sc Hep-G2 C267(0.90)  LDD2227  [8]
 LDCM0367  CL1 HEK-293T C267(1.69); C39(1.05); C42(1.05)  LDD0965  [5]
 LDCM0368  CL10 HEK-293T C267(1.45); C39(2.27); C42(2.27)  LDD0966  [5]
 LDCM0369  CL100 HCT 116 C476(0.72); C482(0.72); C267(1.10)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C267(0.94); C90(1.03); C93(1.03)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C90(0.81); C93(0.81); C267(0.90)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C90(0.86); C93(0.86); C267(0.91)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C90(0.85); C93(0.85); C267(0.96)  LDD0690  [5]
 LDCM0374  CL105 HEK-293T C39(1.36); C42(1.36); C90(1.40); C93(1.40)  LDD0972  [5]
 LDCM0375  CL106 HEK-293T C39(1.27); C42(1.27); C90(0.80); C93(0.80)  LDD0973  [5]
 LDCM0376  CL107 HEK-293T C39(1.17); C42(1.17); C90(1.09); C93(1.09)  LDD0974  [5]
 LDCM0377  CL108 HEK-293T C39(1.15); C42(1.15); C90(1.01); C93(1.01)  LDD0975  [5]
 LDCM0378  CL109 HEK-293T C39(1.11); C42(1.11); C90(1.23); C93(1.23)  LDD0976  [5]
 LDCM0379  CL11 HEK-293T C267(1.39); C39(1.64); C42(1.64)  LDD0977  [5]
 LDCM0380  CL110 HEK-293T C39(1.11); C42(1.11); C90(1.06); C93(1.06)  LDD0978  [5]
 LDCM0381  CL111 HEK-293T C39(1.14); C42(1.14); C90(0.98); C93(0.98)  LDD0979  [5]
 LDCM0382  CL112 HEK-293T C116(0.85); C119(0.85); C39(1.74); C42(1.74)  LDD0980  [5]
 LDCM0383  CL113 HEK-293T C116(0.85); C119(0.85); C39(1.63); C42(1.63)  LDD0981  [5]
 LDCM0384  CL114 HEK-293T C116(0.88); C119(0.88); C39(1.95); C42(1.95)  LDD0982  [5]
 LDCM0385  CL115 HEK-293T C116(0.93); C119(0.93); C39(2.14); C42(2.14)  LDD0983  [5]
 LDCM0386  CL116 HEK-293T C116(0.88); C119(0.88); C39(1.88); C42(1.88)  LDD0984  [5]
 LDCM0387  CL117 HEK-293T C267(1.23); C39(0.97); C42(0.97)  LDD0985  [5]
 LDCM0388  CL118 HEK-293T C267(0.76); C39(0.94); C42(0.94)  LDD0986  [5]
 LDCM0389  CL119 HEK-293T C267(0.66); C39(1.05); C42(1.05)  LDD0987  [5]
 LDCM0390  CL12 HEK-293T C267(1.42); C39(1.03); C42(1.03)  LDD0988  [5]
 LDCM0391  CL120 HEK-293T C267(1.15); C39(1.13); C42(1.13)  LDD0989  [5]
 LDCM0392  CL121 HCT 116 C267(1.02)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C267(1.12)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C267(1.08)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C267(1.05)  LDD0712  [5]
 LDCM0396  CL125 HEK-293T C116(0.83); C119(0.83); C39(1.16); C42(1.16)  LDD0994  [5]
 LDCM0397  CL126 HEK-293T C116(0.93); C119(0.93); C39(0.95); C42(0.95)  LDD0995  [5]
 LDCM0398  CL127 HEK-293T C116(0.91); C119(0.91); C39(0.84); C42(0.84)  LDD0996  [5]
 LDCM0399  CL128 HEK-293T C116(0.85); C119(0.85); C39(1.03); C42(1.03)  LDD0997  [5]
 LDCM0400  CL13 HEK-293T C267(1.16); C39(1.13); C42(1.13)  LDD0998  [5]
 LDCM0401  CL14 HEK-293T C267(1.32); C39(1.14); C42(1.14)  LDD0999  [5]
 LDCM0402  CL15 HEK-293T C267(1.64); C39(1.40); C42(1.40)  LDD1000  [5]
 LDCM0403  CL16 HCT 116 C90(0.92); C93(0.92)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C90(0.84); C93(0.84)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C90(1.13); C93(1.13)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C90(1.10); C93(1.10)  LDD0723  [5]
 LDCM0407  CL2 HEK-293T C267(1.42); C39(1.49); C42(1.49)  LDD1005  [5]
 LDCM0408  CL20 HCT 116 C90(1.10); C93(1.10)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C90(1.22); C93(1.22)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C90(1.67); C93(1.67)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C90(1.24); C93(1.24)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C90(1.12); C93(1.12)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C90(1.55); C93(1.55)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C90(1.17); C93(1.17)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C90(1.11); C93(1.11)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C90(1.26); C93(1.26)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C90(1.25); C93(1.25)  LDD0734  [5]
 LDCM0418  CL3 HEK-293T C267(1.33); C39(2.26); C42(2.26)  LDD1016  [5]
 LDCM0419  CL30 HCT 116 C90(1.48); C93(1.48)  LDD0736  [5]
 LDCM0420  CL31 HEK-293T C267(0.90)  LDD1018  [5]
 LDCM0421  CL32 HEK-293T C267(0.79)  LDD1019  [5]
 LDCM0422  CL33 HEK-293T C267(0.96)  LDD1020  [5]
 LDCM0423  CL34 HEK-293T C267(1.01)  LDD1021  [5]
 LDCM0424  CL35 HEK-293T C267(0.86)  LDD1022  [5]
 LDCM0425  CL36 HEK-293T C267(0.97)  LDD1023  [5]
 LDCM0426  CL37 HEK-293T C267(0.98)  LDD1024  [5]
 LDCM0428  CL39 HEK-293T C267(0.94)  LDD1026  [5]
 LDCM0429  CL4 HEK-293T C267(1.88); C39(1.36); C42(1.36)  LDD1027  [5]
 LDCM0430  CL40 HEK-293T C267(0.95)  LDD1028  [5]
 LDCM0431  CL41 HEK-293T C267(0.84)  LDD1029  [5]
 LDCM0432  CL42 HEK-293T C267(0.98)  LDD1030  [5]
 LDCM0433  CL43 HEK-293T C267(0.90)  LDD1031  [5]
 LDCM0434  CL44 HEK-293T C267(0.93)  LDD1032  [5]
 LDCM0435  CL45 HEK-293T C267(0.90)  LDD1033  [5]
 LDCM0436  CL46 HEK-293T C116(1.14); C119(1.14); C267(0.73); C39(1.75)  LDD1034  [5]
 LDCM0437  CL47 HEK-293T C116(1.07); C119(1.07); C267(0.90); C39(1.29)  LDD1035  [5]
 LDCM0438  CL48 HEK-293T C116(1.15); C119(1.15); C267(1.17); C39(1.48)  LDD1036  [5]
 LDCM0439  CL49 HEK-293T C116(1.12); C119(1.12); C267(0.73); C39(1.21)  LDD1037  [5]
 LDCM0440  CL5 HEK-293T C267(1.37); C39(1.21); C42(1.21)  LDD1038  [5]
 LDCM0441  CL50 HEK-293T C116(1.02); C119(1.02); C267(0.80); C39(1.47)  LDD1039  [5]
 LDCM0442  CL51 HEK-293T C116(1.05); C119(1.05); C267(0.95); C39(1.01)  LDD1040  [5]
 LDCM0443  CL52 HEK-293T C116(1.17); C119(1.17); C267(1.00); C39(1.01)  LDD1041  [5]
 LDCM0444  CL53 HEK-293T C116(1.08); C119(1.08); C267(0.98); C39(0.81)  LDD1042  [5]
 LDCM0445  CL54 HEK-293T C116(1.02); C119(1.02); C267(0.83); C39(0.98)  LDD1043  [5]
 LDCM0446  CL55 HEK-293T C116(0.96); C119(0.96); C267(0.82); C39(1.20)  LDD1044  [5]
 LDCM0447  CL56 HEK-293T C116(1.23); C119(1.23); C267(0.82); C39(1.04)  LDD1045  [5]
 LDCM0448  CL57 HEK-293T C116(1.23); C119(1.23); C267(1.57); C39(1.08)  LDD1046  [5]
 LDCM0449  CL58 HEK-293T C116(1.31); C119(1.31); C267(0.81); C39(0.93)  LDD1047  [5]
 LDCM0450  CL59 HEK-293T C116(1.21); C119(1.21); C267(1.09); C39(1.23)  LDD1048  [5]
 LDCM0451  CL6 HEK-293T C267(1.53); C39(1.19); C42(1.19)  LDD1049  [5]
 LDCM0452  CL60 HEK-293T C116(1.26); C119(1.26); C267(1.10); C39(1.53)  LDD1050  [5]
 LDCM0453  CL61 HCT 116 C476(0.84); C482(0.84); C267(0.97)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C476(1.23); C482(1.23); C267(0.70)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C476(0.54); C482(0.54); C267(0.82)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C476(0.31); C482(0.31); C267(0.74)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C476(0.53); C482(0.53); C267(1.02)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C476(0.67); C482(0.67); C267(0.89)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C476(0.60); C482(0.60); C267(0.79)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C476(0.68); C482(0.68); C267(1.10)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C476(0.98); C482(0.98); C267(0.94)  LDD0778  [5]
 LDCM0462  CL7 HEK-293T C267(1.19); C39(1.64); C42(1.64)  LDD1060  [5]
 LDCM0463  CL70 HCT 116 C476(0.72); C482(0.72); C267(0.92)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C476(0.78); C482(0.78); C267(0.87)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C476(0.86); C482(0.86); C267(0.80)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C476(0.76); C482(0.76); C267(0.84)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C476(0.84); C482(0.84); C267(0.86)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C90(0.91); C93(0.91)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C90(0.95); C93(0.95)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C90(0.83); C93(0.83)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C90(0.90); C93(0.90)  LDD0789  [5]
 LDCM0473  CL8 HEK-293T C42(1.13)  LDD1071  [5]
 LDCM0474  CL80 HCT 116 C90(0.83); C93(0.83)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C90(0.92); C93(0.92)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C90(0.96); C93(0.96)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C90(1.03); C93(1.03)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C90(0.94); C93(0.94)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C90(1.08); C93(1.08)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C90(1.06); C93(1.06)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C90(1.30); C93(1.30)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C90(1.02); C93(1.02)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C90(1.05); C93(1.05)  LDD0800  [5]
 LDCM0484  CL9 HEK-293T C42(1.85)  LDD1082  [5]
 LDCM0485  CL90 HCT 116 C90(0.89); C93(0.89)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C476(0.64); C482(0.64); C267(1.07)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C476(0.93); C482(0.93); C267(0.94)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C476(0.42); C482(0.42); C267(0.82)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C476(0.65); C482(0.65); C267(0.77)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C476(0.65); C482(0.65); C267(0.91)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C476(0.52); C482(0.52); C267(0.95)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C476(0.55); C482(0.55); C267(0.85)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C476(0.76); C482(0.76); C267(1.20)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C476(0.70); C482(0.70); C267(0.75)  LDD0811  [5]
 LDCM0634  CY-0357 Hep-G2 C267(1.60)  LDD2228  [8]
 LDCM0495  E2913 HEK-293T C109(1.01); C267(1.07); C482(1.25); C60(1.10)  LDD1698  [15]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C476(1.03); C482(0.91)  LDD1702  [2]
 LDCM0031  Epigallocatechin gallate HEK-293T 5.13  LDD0183  [1]
 LDCM0625  F8 Ramos C267(0.89)  LDD2187  [16]
 LDCM0572  Fragment10 Ramos C267(1.14)  LDD2189  [16]
 LDCM0573  Fragment11 Ramos C267(20.00)  LDD2190  [16]
 LDCM0574  Fragment12 Ramos C267(0.79)  LDD2191  [16]
 LDCM0575  Fragment13 Ramos C267(1.06)  LDD2192  [16]
 LDCM0576  Fragment14 Ramos C267(0.92)  LDD2193  [16]
 LDCM0579  Fragment20 Ramos C267(0.68)  LDD2194  [16]
 LDCM0580  Fragment21 Ramos C267(1.08)  LDD2195  [16]
 LDCM0578  Fragment27 Ramos C267(1.26)  LDD2197  [16]
 LDCM0586  Fragment28 Ramos C267(0.73)  LDD2198  [16]
 LDCM0588  Fragment30 Ramos C267(1.44)  LDD2199  [16]
 LDCM0589  Fragment31 Ramos C267(1.02)  LDD2200  [16]
 LDCM0590  Fragment32 Ramos C267(1.00)  LDD2201  [16]
 LDCM0468  Fragment33 HCT 116 C476(0.72); C482(0.72); C267(0.71)  LDD0785  [5]
 LDCM0596  Fragment38 Ramos C267(0.62)  LDD2203  [16]
 LDCM0566  Fragment4 Ramos C267(0.64)  LDD2184  [16]
 LDCM0427  Fragment51 HEK-293T C267(0.91)  LDD1025  [5]
 LDCM0569  Fragment7 Ramos C267(0.45)  LDD2186  [16]
 LDCM0571  Fragment9 Ramos C267(0.93)  LDD2188  [16]
 LDCM0022  KB02 HCT 116 C476(2.17); C482(2.17); C90(1.19); C93(1.19)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C476(1.11); C482(1.11); C90(1.44); C93(1.44)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C476(1.70); C482(1.70); C90(1.32); C93(1.32)  LDD0082  [5]
 LDCM0030  Luteolin HEK-293T 4.50  LDD0182  [1]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C135(1.06)  LDD2093  [2]
 LDCM0627  NUDT7-COV-1 HEK-293T C267(0.69)  LDD2206  [17]
 LDCM0628  OTUB2-COV-1 HEK-293T C267(0.59)  LDD2207  [17]
 LDCM0021  THZ1 HCT 116 C60(1.64); C64(1.64); C135(1.09); C90(1.42)  LDD2173  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (NGLY1) PNGase family Q96IV0
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858

References

1 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
13 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
14 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
17 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.