Details of the Target
General Information of Target
| Target ID | LDTP06334 | |||||
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| Target Name | Serum paraoxonase/lactonase 3 (PON3) |
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| Gene Name | PON3 | |||||
| Gene ID | 5446 | |||||
| Synonyms |
Serum paraoxonase/lactonase 3; EC 3.1.1.2; EC 3.1.1.81; EC 3.1.8.1 |
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| 3D Structure | ||||||
| Sequence |
MGKLVALVLLGVGLSLVGEMFLAFRERVNASREVEPVEPENCHLIEELESGSEDIDILPS
GLAFISSGLKYPGMPNFAPDEPGKIFLMDLNEQNPRAQALEISGGFDKELFNPHGISIFI DKDNTVYLYVVNHPHMKSTVEIFKFEEQQRSLVYLKTIKHELLKSVNDIVVLGPEQFYAT RDHYFTNSLLSFFEMILDLRWTYVLFYSPREVKVVAKGFCSANGITVSADQKYVYVADVA AKNIHIMEKHDNWDLTQLKVIQLGTLVDNLTVDPATGDILAGCHPNPMKLLNYNPEDPPG SEVLRIQNVLSEKPRVSTVYANNGSVLQGTSVASVYHGKILIGTVFHKTLYCEL |
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| Target Bioclass |
Enzyme
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| Family |
Paraoxonase family
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| Subcellular location |
Secreted, extracellular space
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| Function |
Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
| ChEMBL ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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DBIA Probe Info |
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C220(2.11) | LDD3319 | [1] | |
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Acrolein Probe Info |
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K159(0.00); H160(0.00) | LDD0223 | [2] | |
PAL-AfBPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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ILS-1 PP Probe Info |
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5.62 | LDD0417 | [3] | |
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A-DA Probe Info |
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2.93 | LDD0145 | [4] | |
Competitor(s) Related to This Target
| Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
|---|---|---|---|---|---|
| LDCM0022 | KB02 | Hep 3B2.1-7 | C220(1.53) | LDD2353 | [1] |
| LDCM0023 | KB03 | Hep 3B2.1-7 | C220(2.23) | LDD2770 | [1] |
| LDCM0024 | KB05 | MEWO | C220(2.11) | LDD3319 | [1] |
| LDCM0109 | NEM | HeLa | K159(0.00); H160(0.00) | LDD0223 | [2] |
| LDCM0084 | Ro 48-8071 | A-549 | 2.93 | LDD0145 | [4] |
The Interaction Atlas With This Target
References