Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name ART-yne  Probe Info 
Probe concentration 50 mM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
LFQ
Competitor Name Astemisinin  Competitor Info 
Competitor Concentration 50 mM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Breast
Disease Model Invasive breast carcinoma [ICD-11:2C60]
Model Name Human invasive breast carcinoma cells (MCF-7)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 3 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP11994  Palmitoyltransferase ZDHHC6 (ZDHHC6) 3.3
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 2.1
 LDTP02054  Cytochrome P450 1A1 (CYP1A1) 1.7
Transporter and channel
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04873  Reactive oxygen species modulator 1 (ROMO1) 2.1
 LDTP09651  Choline transporter-like protein 1 (SLC44A1) 1.8

References

1 Artemisinin inhibits NRas palmitoylation by targeting the protein acyltransferase ZDHHC6. Cell Chem Biol. 2022 Mar 17;29(3):530-537.e7. doi: 10.1016/j.chembiol.2021.07.012. Epub 2021 Aug 5.