Details of the Target

General Information of Target

Target ID LDTP05215
Target Name Very low-density lipoprotein receptor (VLDLR)
Gene Name VLDLR
Gene ID 7436
Synonyms
Very low-density lipoprotein receptor; VLDL receptor; VLDL-R
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGTSALWALWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVD
GSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISC
GAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCS
DGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCP
ASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGI
RDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINEC
LVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCE
CSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAA
QKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVA
TLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQ
WPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWI
DGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCL
PAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATTVTYSETKDTNTTEISATSGLVPGGI
NVTTAVSEVSVPPKGTSAAWAILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKT
TEEDLSIDIGRHSASVGHTYPAISVVSTDDDLA
Target Bioclass
Other
Subcellular location
Cell membrane
Function
Multifunctional cell surface receptor that binds VLDL and transports it into cells by endocytosis and therefore plays an important role in energy metabolism. Binds also to a wide range of other molecules including Reelin/RELN or apolipoprotein E/APOE-containing ligands as well as clusterin/CLU. In the off-state of the pathway, forms homooligomers or heterooligomers with LRP8. Upon binding to ligands, homooligomers are rearranged to higher order receptor clusters that transmit the extracellular RELN signal to intracellular signaling processes by binding to DAB1. This interaction results in phosphorylation of DAB1 leading to the ultimate cell responses required for the correct positioning of newly generated neurons. Later, mediates a stop signal for migrating neurons, preventing them from entering the marginal zone.; (Microbial infection) Acts as a receptor for Semliki Forest virus.
Uniprot ID
P98155
Ensemble ID
ENST00000382100.8
HGNC ID
HGNC:12698

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A431 SNV: p.E582Q .
AGS Insertion: p.F494CfsTer8 .
FTC133 SNV: p.V836M .
HCT15 SNV: p.A122T .
HEC1 SNV: p.R820W .
HEC1B SNV: p.R820W .
HT115 SNV: p.D390Y .
HUCCT1 SNV: p.V520A .
KASUMI2 SNV: p.C264W .
LNCaP clone FGC SNV: p.H728R .
MCC13 SNV: p.G779E .
NCIH1155 SNV: p.T530I DBIA    Probe Info 
NCIH1944 SNV: p.Y694F .
RKO SNV: p.A18V .
U937 SNV: p.P441S .
WM2664 Insertion: p.S225VfsTer30; p.C382WfsTer6 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		3.68  LDD0318  [1]
DBIA
 Probe Info  		C338(3.62); C344(3.62)  LDD0080  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [3]
IA-alkyne
 Probe Info  		C45(0.00); C318(0.00); C331(0.00)  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		C45(0.00); C318(0.00); C331(0.00)  LDD0037  [3]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C170
 Probe Info  		33.59  LDD1850  [4]
C171
 Probe Info  		8.88  LDD1851  [4]
C310
 Probe Info  		27.86  LDD1977  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C318(1.08); C45(1.36)  LDD1507  [5]
 LDCM0226  AC11 HEK-293T C355(0.84)  LDD1509  [5]
 LDCM0237  AC12 HEK-293T C318(1.05); C45(1.14); C355(0.96)  LDD1510  [5]
 LDCM0259  AC14 HEK-293T C318(0.96); C45(0.99); C355(1.25); C367(1.18)  LDD1512  [5]
 LDCM0270  AC15 HEK-293T C318(0.79); C355(1.12)  LDD1513  [5]
 LDCM0276  AC17 HEK-293T C318(0.91); C45(0.82)  LDD1515  [5]
 LDCM0278  AC19 HEK-293T C355(1.00)  LDD1517  [5]
 LDCM0280  AC20 HEK-293T C318(0.91); C45(1.40); C355(1.02)  LDD1519  [5]
 LDCM0281  AC21 HEK-293T C318(1.04); C355(1.21)  LDD1520  [5]
 LDCM0282  AC22 HEK-293T C318(1.03); C45(1.10); C355(0.97); C367(1.04)  LDD1521  [5]
 LDCM0283  AC23 HEK-293T C318(0.84); C355(0.93)  LDD1522  [5]
 LDCM0284  AC24 HEK-293T C318(0.95); C355(1.28)  LDD1523  [5]
 LDCM0285  AC25 HEK-293T C318(1.11); C45(0.95)  LDD1524  [5]
 LDCM0287  AC27 HEK-293T C355(1.01)  LDD1526  [5]
 LDCM0288  AC28 HEK-293T C318(1.40); C45(1.25); C355(1.22)  LDD1527  [5]
 LDCM0289  AC29 HEK-293T C318(1.12); C355(1.03)  LDD1528  [5]
 LDCM0290  AC3 HEK-293T C355(1.09)  LDD1529  [5]
 LDCM0291  AC30 HEK-293T C318(0.96); C45(1.01); C355(1.13); C367(1.42)  LDD1530  [5]
 LDCM0292  AC31 HEK-293T C318(1.05); C355(0.91)  LDD1531  [5]
 LDCM0293  AC32 HEK-293T C318(0.79); C355(1.04)  LDD1532  [5]
 LDCM0294  AC33 HEK-293T C318(1.00); C45(0.91)  LDD1533  [5]
 LDCM0296  AC35 HEK-293T C355(0.97)  LDD1535  [5]
 LDCM0297  AC36 HEK-293T C318(1.18); C45(1.27); C355(1.03)  LDD1536  [5]
 LDCM0298  AC37 HEK-293T C318(0.91); C355(1.05)  LDD1537  [5]
 LDCM0299  AC38 HEK-293T C318(1.13); C45(1.11); C355(1.01); C367(0.88)  LDD1538  [5]
 LDCM0300  AC39 HEK-293T C318(0.87); C355(0.97)  LDD1539  [5]
 LDCM0301  AC4 HEK-293T C318(0.93); C45(1.02); C355(0.92)  LDD1540  [5]
 LDCM0302  AC40 HEK-293T C318(1.02); C355(1.02)  LDD1541  [5]
 LDCM0303  AC41 HEK-293T C318(1.13); C45(1.43)  LDD1542  [5]
 LDCM0305  AC43 HEK-293T C355(1.14)  LDD1544  [5]
 LDCM0306  AC44 HEK-293T C318(0.99); C45(0.98); C355(0.94)  LDD1545  [5]
 LDCM0307  AC45 HEK-293T C318(1.18); C355(1.02)  LDD1546  [5]
 LDCM0308  AC46 HEK-293T C318(1.12); C45(0.89); C355(1.05); C367(1.06)  LDD1547  [5]
 LDCM0309  AC47 HEK-293T C318(1.10); C355(0.93)  LDD1548  [5]
 LDCM0310  AC48 HEK-293T C318(0.97); C355(1.09)  LDD1549  [5]
 LDCM0311  AC49 HEK-293T C318(0.82); C45(0.98)  LDD1550  [5]
 LDCM0312  AC5 HEK-293T C318(0.97); C355(1.03)  LDD1551  [5]
 LDCM0314  AC51 HEK-293T C355(0.96)  LDD1553  [5]
 LDCM0315  AC52 HEK-293T C318(0.89); C45(1.06); C355(0.99)  LDD1554  [5]
 LDCM0316  AC53 HEK-293T C318(1.03); C355(1.05)  LDD1555  [5]
 LDCM0317  AC54 HEK-293T C318(0.89); C45(0.99); C355(0.90); C367(1.08)  LDD1556  [5]
 LDCM0318  AC55 HEK-293T C318(0.87); C355(1.10)  LDD1557  [5]
 LDCM0319  AC56 HEK-293T C318(0.94); C355(1.05)  LDD1558  [5]
 LDCM0320  AC57 HEK-293T C318(0.84); C45(1.04)  LDD1559  [5]
 LDCM0322  AC59 HEK-293T C355(1.10)  LDD1561  [5]
 LDCM0323  AC6 HEK-293T C318(0.85); C45(1.19); C355(0.97); C367(1.09)  LDD1562  [5]
 LDCM0324  AC60 HEK-293T C318(0.83); C45(1.01); C355(1.07)  LDD1563  [5]
 LDCM0325  AC61 HEK-293T C318(0.99); C355(1.07)  LDD1564  [5]
 LDCM0326  AC62 HEK-293T C318(1.38); C45(1.13); C355(1.01); C367(1.16)  LDD1565  [5]
 LDCM0327  AC63 HEK-293T C318(1.03); C355(1.19)  LDD1566  [5]
 LDCM0328  AC64 HEK-293T C318(1.00); C355(0.97)  LDD1567  [5]
 LDCM0334  AC7 HEK-293T C318(0.98); C355(1.07)  LDD1568  [5]
 LDCM0345  AC8 HEK-293T C318(0.82); C355(1.14)  LDD1569  [5]
 LDCM0248  AKOS034007472 HEK-293T C318(0.87); C355(1.14)  LDD1511  [5]
 LDCM0356  AKOS034007680 HEK-293T C318(1.17); C45(1.62)  LDD1570  [5]
 LDCM0275  AKOS034007705 HEK-293T C318(1.06); C355(1.00)  LDD1514  [5]
 LDCM0368  CL10 HEK-293T C318(1.33); C45(1.00); C355(1.25); C367(1.13)  LDD1572  [5]
 LDCM0369  CL100 HEK-293T C45(1.02); C355(1.28)  LDD1573  [5]
 LDCM0371  CL102 HEK-293T C318(0.73); C338(0.80)  LDD1575  [5]
 LDCM0372  CL103 HEK-293T C318(1.01)  LDD1576  [5]
 LDCM0373  CL104 HEK-293T C45(1.14); C355(0.97)  LDD1577  [5]
 LDCM0375  CL106 HEK-293T C318(1.01); C338(0.88)  LDD1579  [5]
 LDCM0376  CL107 HEK-293T C318(0.98)  LDD1580  [5]
 LDCM0377  CL108 HEK-293T C45(1.13); C355(0.89)  LDD1581  [5]
 LDCM0379  CL11 HEK-293T C318(1.09); C355(0.93)  LDD1583  [5]
 LDCM0380  CL110 HEK-293T C318(0.78); C338(0.81)  LDD1584  [5]
 LDCM0381  CL111 HEK-293T C318(1.08)  LDD1585  [5]
 LDCM0382  CL112 HEK-293T C45(1.07); C355(1.01)  LDD1586  [5]
 LDCM0384  CL114 HEK-293T C318(0.90); C338(1.50)  LDD1588  [5]
 LDCM0385  CL115 HEK-293T C318(0.84)  LDD1589  [5]
 LDCM0386  CL116 HEK-293T C45(1.04); C355(1.07)  LDD1590  [5]
 LDCM0388  CL118 HEK-293T C318(0.85); C338(0.76)  LDD1592  [5]
 LDCM0389  CL119 HEK-293T C318(0.96)  LDD1593  [5]
 LDCM0390  CL12 HEK-293T C318(0.91); C355(1.14)  LDD1594  [5]
 LDCM0391  CL120 HEK-293T C45(1.12); C355(1.37)  LDD1595  [5]
 LDCM0393  CL122 HEK-293T C318(0.85); C338(0.82)  LDD1597  [5]
 LDCM0394  CL123 HEK-293T C318(1.25)  LDD1598  [5]
 LDCM0395  CL124 HEK-293T C45(1.11); C355(0.91)  LDD1599  [5]
 LDCM0397  CL126 HEK-293T C318(1.05); C338(0.85)  LDD1601  [5]
 LDCM0398  CL127 HEK-293T C318(0.94)  LDD1602  [5]
 LDCM0399  CL128 HEK-293T C45(1.12); C355(0.94)  LDD1603  [5]
 LDCM0401  CL14 HEK-293T C318(1.11); C338(0.78)  LDD1605  [5]
 LDCM0402  CL15 HEK-293T C318(0.91)  LDD1606  [5]
 LDCM0403  CL16 HEK-293T C45(1.04); C355(1.21)  LDD1607  [5]
 LDCM0404  CL17 HEK-293T C318(0.80); C45(0.61)  LDD1608  [5]
 LDCM0406  CL19 HEK-293T C355(0.83)  LDD1610  [5]
 LDCM0407  CL2 HEK-293T C318(0.90); C338(1.05)  LDD1611  [5]
 LDCM0408  CL20 HEK-293T C318(1.12); C45(1.00); C355(0.95)  LDD1612  [5]
 LDCM0409  CL21 HEK-293T C318(1.03); C355(0.93)  LDD1613  [5]
 LDCM0410  CL22 HEK-293T C318(1.00); C45(1.07); C355(1.10); C367(1.11)  LDD1614  [5]
 LDCM0411  CL23 HEK-293T C318(0.93); C355(0.99)  LDD1615  [5]
 LDCM0412  CL24 HEK-293T C318(0.99); C355(0.94)  LDD1616  [5]
 LDCM0414  CL26 HEK-293T C318(1.00); C338(0.84)  LDD1618  [5]
 LDCM0415  CL27 HEK-293T C318(1.12)  LDD1619  [5]
 LDCM0416  CL28 HEK-293T C45(0.92); C355(1.01)  LDD1620  [5]
 LDCM0417  CL29 HEK-293T C318(1.25); C45(1.12)  LDD1621  [5]
 LDCM0418  CL3 HEK-293T C318(0.86)  LDD1622  [5]
 LDCM0420  CL31 HEK-293T C355(0.82)  LDD1624  [5]
 LDCM0421  CL32 HEK-293T C318(1.15); C45(1.31); C355(1.08)  LDD1625  [5]
 LDCM0422  CL33 HEK-293T C318(1.21); C355(0.80)  LDD1626  [5]
 LDCM0423  CL34 HEK-293T C318(1.14); C45(1.17); C355(0.93); C367(0.77)  LDD1627  [5]
 LDCM0424  CL35 HEK-293T C318(0.94); C355(0.93)  LDD1628  [5]
 LDCM0425  CL36 HEK-293T C318(0.84); C355(1.02)  LDD1629  [5]
 LDCM0428  CL39 HEK-293T C318(1.25)  LDD1632  [5]
 LDCM0429  CL4 HEK-293T C45(0.94); C355(1.20)  LDD1633  [5]
 LDCM0430  CL40 HEK-293T C45(1.07); C355(0.85)  LDD1634  [5]
 LDCM0431  CL41 HEK-293T C318(1.12); C45(0.73)  LDD1635  [5]
 LDCM0433  CL43 HEK-293T C355(0.84)  LDD1637  [5]
 LDCM0434  CL44 HEK-293T C318(0.92); C45(1.17); C355(0.91)  LDD1638  [5]
 LDCM0435  CL45 HEK-293T C318(1.10); C355(1.10)  LDD1639  [5]
 LDCM0436  CL46 HEK-293T C318(0.91); C45(1.16); C355(0.94); C367(1.27)  LDD1640  [5]
 LDCM0437  CL47 HEK-293T C318(0.99); C355(0.98)  LDD1641  [5]
 LDCM0438  CL48 HEK-293T C318(0.99); C355(0.98)  LDD1642  [5]
 LDCM0440  CL5 HEK-293T C318(0.84); C45(0.87)  LDD1644  [5]
 LDCM0441  CL50 HEK-293T C318(1.06); C338(1.43)  LDD1645  [5]
 LDCM0443  CL52 HEK-293T C45(0.95); C355(1.09)  LDD1646  [5]
 LDCM0444  CL53 HEK-293T C318(1.29); C45(1.14)  LDD1647  [5]
 LDCM0446  CL55 HEK-293T C355(1.12)  LDD1649  [5]
 LDCM0447  CL56 HEK-293T C318(0.81); C45(1.44); C355(0.96)  LDD1650  [5]
 LDCM0448  CL57 HEK-293T C318(1.06); C355(1.37)  LDD1651  [5]
 LDCM0449  CL58 HEK-293T C318(1.11); C45(1.15); C355(1.06); C367(1.54)  LDD1652  [5]
 LDCM0450  CL59 HEK-293T C318(1.02); C355(1.00)  LDD1653  [5]
 LDCM0452  CL60 HEK-293T C318(1.42); C355(1.00)  LDD1655  [5]
 LDCM0454  CL62 HEK-293T C318(0.98); C338(0.81)  LDD1657  [5]
 LDCM0455  CL63 HEK-293T C318(0.98)  LDD1658  [5]
 LDCM0456  CL64 HEK-293T C45(0.92); C355(0.98)  LDD1659  [5]
 LDCM0457  CL65 HEK-293T C318(1.11); C45(1.13)  LDD1660  [5]
 LDCM0459  CL67 HEK-293T C355(1.32)  LDD1662  [5]
 LDCM0460  CL68 HEK-293T C318(0.92); C45(1.30); C355(0.96)  LDD1663  [5]
 LDCM0461  CL69 HEK-293T C318(1.14); C355(0.94)  LDD1664  [5]
 LDCM0462  CL7 HEK-293T C355(0.97)  LDD1665  [5]
 LDCM0463  CL70 HEK-293T C318(1.50); C45(1.01); C355(0.96); C367(0.92)  LDD1666  [5]
 LDCM0464  CL71 HEK-293T C318(1.10); C355(0.94)  LDD1667  [5]
 LDCM0465  CL72 HEK-293T C318(1.25); C355(1.31)  LDD1668  [5]
 LDCM0467  CL74 HEK-293T C318(1.09); C338(0.75)  LDD1670  [5]
 LDCM0469  CL76 HEK-293T C45(1.07); C355(1.04)  LDD1672  [5]
 LDCM0470  CL77 HEK-293T C318(0.81); C45(0.68)  LDD1673  [5]
 LDCM0472  CL79 HEK-293T C355(1.06)  LDD1675  [5]
 LDCM0473  CL8 HEK-293T C318(1.44); C45(0.30); C355(1.03)  LDD1676  [5]
 LDCM0474  CL80 HEK-293T C318(1.03); C45(1.12); C355(1.06)  LDD1677  [5]
 LDCM0475  CL81 HEK-293T C318(1.05); C355(1.04)  LDD1678  [5]
 LDCM0476  CL82 HEK-293T C318(1.26); C45(0.94); C355(0.89); C367(1.10)  LDD1679  [5]
 LDCM0477  CL83 HEK-293T C318(1.01); C355(0.99)  LDD1680  [5]
 LDCM0478  CL84 HEK-293T C318(1.05); C355(0.81)  LDD1681  [5]
 LDCM0480  CL86 HEK-293T C318(0.95); C338(0.89)  LDD1683  [5]
 LDCM0481  CL87 HEK-293T C318(1.62)  LDD1684  [5]
 LDCM0482  CL88 HEK-293T C45(0.94); C355(1.14)  LDD1685  [5]
 LDCM0483  CL89 HEK-293T C318(0.79); C45(1.33)  LDD1686  [5]
 LDCM0484  CL9 HEK-293T C318(0.87); C355(0.96)  LDD1687  [5]
 LDCM0486  CL91 HEK-293T C355(1.00)  LDD1689  [5]
 LDCM0487  CL92 HEK-293T C318(1.05); C45(0.96); C355(1.08)  LDD1690  [5]
 LDCM0488  CL93 HEK-293T C318(1.25); C355(1.12)  LDD1691  [5]
 LDCM0489  CL94 HEK-293T C318(1.10); C45(0.97); C355(0.85); C367(1.18)  LDD1692  [5]
 LDCM0490  CL95 HEK-293T C318(1.14); C355(1.29)  LDD1693  [5]
 LDCM0491  CL96 HEK-293T C318(0.92); C355(0.94)  LDD1694  [5]
 LDCM0493  CL98 HEK-293T C318(0.94); C338(0.86)  LDD1696  [5]
 LDCM0494  CL99 HEK-293T C318(0.93)  LDD1697  [5]
 LDCM0495  E2913 HEK-293T C318(1.63)  LDD1698  [5]
 LDCM0468  Fragment33 HEK-293T C318(1.14)  LDD1671  [5]
 LDCM0427  Fragment51 HEK-293T C318(1.15); C338(0.87)  LDD1631  [5]
 LDCM0022  KB02 HCT 116 C338(3.62); C344(3.62)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C338(2.86); C344(2.86)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C338(3.94); C344(3.94)  LDD0082  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger and SCAN domain-containing protein 12 (ZSCAN12) Krueppel C2H2-type zinc-finger protein family O43309
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha-2-macroglobulin receptor-associated protein (LRPAP1) Alpha-2-MRAP family P30533

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Lauric Acid Small molecular drug DB03017
Ubidecarenone . DB09270

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
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Mass spectrometry data entry: PXD028853
4 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
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Mass spectrometry data entry: PXD044402