Details of the Target

General Information of Target

Target ID LDTP00888
Target Name EGF-like repeat and discoidin I-like domain-containing protein 3 (EDIL3)
Gene Name EDIL3
Gene ID 10085
Synonyms
DEL1; EGF-like repeat and discoidin I-like domain-containing protein 3; Developmentally-regulated endothelial cell locus 1 protein; Integrin-binding protein DEL1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKRSVAVWLLVGLSLGVPQFGKGDICDPNPCENGGICLPGLADGSFSCECPDGFTDPNCS
SVVEVASDEEEPTSAGPCTPNPCHNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNI
NECEVEPCKNGGICTDLVANYSCECPGEFMGRNCQYKCSGPLGIEGGIISNQQITASSTH
RALFGLQKWYPYYARLNKKGLINAWTAAENDRWPWIQINLQRKMRVTGVITQGAKRIGSP
EYIKSYKIAYSNDGKTWAMYKVKGTNEDMVFRGNIDNNTPYANSFTPPIKAQYVRLYPQV
CRRHCTLRMELLGCELSGCSEPLGMKSGHIQDYQITASSIFRTLNMDMFTWEPRKARLDK
QGKVNAWTSGHNDQSQWLQVDLLVPTKVTGIITQGAKDFGHVQFVGSYKLAYSNDGEHWT
VYQDEKQRKDKVFQGNFDNDTHRKNVIDPPIYARHIRILPWSWYGRITLRSELLGCTEEE
Target Bioclass
Enzyme
Subcellular location
Secreted
Function
Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of vascular-like structures. May be involved in regulation of vascular morphogenesis of remodeling in embryonic development.
Uniprot ID
O43854
Ensemble ID
ENST00000296591.10
HGNC ID
HGNC:3173

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO829 SNV: p.Q187K .
D283MED SNV: p.S375Ter .
HCC15 SNV: p.W419C .
HCT15 SNV: p.A258S .
HGC27 SNV: p.P72A .
IGR1 SNV: p.G110E .
IGROV1 SNV: p.L344P .
L428 SNV: p.D430E .
MEWO SNV: p.G86E .
MKN1 SNV: p.R308Ter .
NCIH2286 SNV: p.A234D .
NCIH23 Deletion: p.Y95TfsTer7 .
OVISE SNV: p.Q173K .
PANC0403 SNV: p.K223E .
RKO SNV: p.T286I .
SUPT1 SNV: p.D347G .
SW1783 SNV: p.R195H .
UACC257 SNV: p.R443S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		4.67  LDD0324  [1]
STPyne
 Probe Info  		K235(7.38); K244(7.72); K255(10.00); K263(1.06)  LDD0277  [2]
OPA-S-S-alkyne
 Probe Info  		K429(1.21); K431(1.29); K290(2.39); K106(2.57)  LDD3494  [3]
DBIA
 Probe Info  		C301(1.33)  LDD3312  [4]
Acrolein
 Probe Info  		N.A.  LDD0217  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [5]
 LDCM0107  IAA HeLa N.A.  LDD0221  [5]
 LDCM0022  KB02 HMCB C301(1.29)  LDD2478  [4]
 LDCM0023  KB03 HMCB C301(1.35)  LDD2895  [4]
 LDCM0024  KB05 HMCB C301(1.33)  LDD3312  [4]
 LDCM0109  NEM HeLa N.A.  LDD0223  [5]

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.