Details of the Target

General Information of Target

Target ID LDTP07698
Target Name Plexin domain-containing protein 2 (PLXDC2)
Gene Name PLXDC2
Gene ID 84898
Synonyms
TEM7R; Plexin domain-containing protein 2; Tumor endothelial marker 7-related protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MARFPKADLAAAGVMLLCHFFTDQFQFADGKPGDQILDWQYGVTQAFPHTEEEVEVDSHA
YSHRWKRNLDFLKAVDTNRASVGQDSPEPRSFTDLLLDDGQDNNTQIEEDTDHNYYISRI
YGPSDSASRDLWVNIDQMEKDKVKIHGILSNTHRQAARVNLSFDFPFYGHFLREITVATG
GFIYTGEVVHRMLTATQYIAPLMANFDPSVSRNSTVRYFDNGTALVVQWDHVHLQDNYNL
GSFTFQATLLMDGRIIFGYKEIPVLVTQISSTNHPVKVGLSDAFVVVHRIQQIPNVRRRT
IYEYHRVELQMSKITNISAVEMTPLPTCLQFNRCGPCVSSQIGFNCSWCSKLQRCSSGFD
RHRQDWVDSGCPEESKEKMCENTEPVETSSRTTTTVGATTTQFRVLTTTRRAVTSQFPTS
LPTEDDTKIALHLKDNGASTDDSAAEKKGGTLHAGLIIGILILVLIVATAILVTVYMYHH
PTSAASIFFIERRPSRWPAMKFRRGSGHPAYAEVEPVGEKEGFIVSEQC
Target Bioclass
Other
Family
Plexin family
Subcellular location
Membrane
Function May play a role in tumor angiogenesis.
Uniprot ID
Q6UX71
Ensemble ID
ENST00000377242.7
HGNC ID
HGNC:21013

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A204 SNV: p.H190R .
A375 SNV: p.T451A .
DOTC24510 SNV: p.V514L .
G415 SNV: p.H479Y .
HLF SNV: p.R504T .
MEWO SNV: p.R411K .
PANC0403 SNV: p.E513K .
SKN SNV: p.S420I .
SUDHL6 SNV: p.A468S .
SW1573 SNV: p.T409I .
TE11 SNV: p.W65Ter .
TYKNU SNV: p.A127T .
WM2664 Insertion: p.M1? .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		3.37  LDD0324  [1]

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580