Details of the Target

General Information of Target

Target ID LDTP03624
Target Name Neural cell adhesion molecule L1 (L1CAM)
Gene Name L1CAM
Gene ID 3897
Synonyms
CAML1; MIC5; Neural cell adhesion molecule L1; N-CAM-L1; NCAM-L1; CD antigen CD171
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVVALRYVWPLLLCSPCLLIQIPEEYEGHHVMEPPVITEQSPRRLVVFPTDDISLKCEAS
GKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKL
GTAMSHEIRLMAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIK
QDERVTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKP
RLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLL
KVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRP
QPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIY
VVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYANG
TLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQ
ASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVV
ESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPE
KWYSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVD
VKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQEQIVSDPFLVVSNTST
FVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQ
VKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNG
RGSGPASEFTFSTPEGVPGHPEALHLECQSNTSLLLRWQPPLSHNGVLTGYVLSYHPLDE
GGKGQLSFNLRDPELRTHNLTDLSPHLRYRFQLQATTKEGPGEAIVREGGTMALSGISDF
GNISATAGENYSVVSWVPKEGQCNFRFHILFKALGEEKGGASLSPQYVSYNQSSYTQWDL
QPDTDYEIHLFKERMFRHQMAVKTNGTGRVRLPPAGFATEGWFIGFVSAIILLLLVLLIL
CFIKRSKGGKYSVKDKEDTQVDSEARPMKDETFGEYRSLESDNEEKAFGSSQPSLNGDIK
PLGSDDSLADYGGSVDVQFNEDGSFIGQYSGKKEKEAAGGNDSSGATSPINPAVALE
Target Type
Clinical trial
Target Bioclass
Immunoglobulin
Family
Immunoglobulin superfamily, L1/neurofascin/NgCAM family
Subcellular location
Cell membrane
Function
Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity.
TTD ID
T80020
Uniprot ID
P32004
DrugMap ID
TTC9D3K
Ensemble ID
ENST00000361699.8
HGNC ID
HGNC:6470
ChEMBL ID
CHEMBL5169129

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.P783H .
HEC1 SNV: p.A541T; p.R760Ter .
HEC1B SNV: p.N233K .
HT1376 SNV: p.A712T DBIA    Probe Info 
HUCCT1 SNV: p.R534G .
JHH7 SNV: p.Y888H .
JURKAT Deletion: p.P162QfsTer11 .
KYSE410 SNV: p.D1182H .
LNCaP clone FGC SNV: p.L13H .
MCC13 SNV: p.R558Ter; p.D720N; p.E822K .
MFE319 SNV: p.I1131T .
MOLT4 SNV: p.S590N .
MONOMAC6 SNV: p.Q361K .
SAOS2 SNV: p.D52A; p.R287G .
SNGM SNV: p.R68H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		13.72  LDD0318  [1]
STPyne
 Probe Info  		K1052(1.35)  LDD0277  [2]
OPA-S-S-alkyne
 Probe Info  		K144(1.10); K180(1.59); K515(1.77); K62(2.25)  LDD3494  [3]
DBIA
 Probe Info  		C312(6.38); C1043(4.87); C158(1.83)  LDD3332  [4]
BTD
 Probe Info  		C1043(0.80)  LDD2136  [5]
AZ-9
 Probe Info  		10.00  LDD2154  [6]
5E-2FA
 Probe Info  		H91(0.00); H624(0.00)  LDD2235  [7]
m-APA
 Probe Info  		H91(0.00); H624(0.00); H684(0.00)  LDD2231  [7]
IPM
 Probe Info  		N.A.  LDD0147  [8]
TFBX
 Probe Info  		N.A.  LDD0148  [8]
Acrolein
 Probe Info  		C404(0.00); C354(0.00); C312(0.00)  LDD0217  [9]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [9]
Methacrolein
 Probe Info  		C354(0.00); C158(0.00)  LDD0218  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0151  AZ-11 HeLa 10.00  LDD2154  [6]
 LDCM0108  Chloroacetamide HeLa C404(0.00); C158(0.00); C354(0.00); C312(0.00)  LDD0222  [9]
 LDCM0107  IAA HeLa H624(0.00); H1098(0.00)  LDD0221  [9]
 LDCM0022  KB02 8305C C1043(1.69); C404(1.52)  LDD2248  [4]
 LDCM0023  KB03 8505C C312(21.99); C1043(5.64); C158(3.39); C404(8.71)  LDD2666  [4]
 LDCM0024  KB05 MKN45 C312(6.38); C1043(4.87); C158(1.83)  LDD3332  [4]
 LDCM0109  NEM HeLa N.A.  LDD0223  [9]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C1043(0.80)  LDD2136  [5]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ethanol Small molecular drug DB00898
Phase 1
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cd171 Specific Car T Cells Expressing Egfrt CAR T Cell Therapy D05KFH
Jcar023 . D0M9TO

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.