Details of the Target

General Information of Target

Target ID LDTP04624
Target Name Sodium/potassium-transporting ATPase subunit beta-3 (ATP1B3)
Gene Name ATP1B3
Gene ID 483
Synonyms
Sodium/potassium-transporting ATPase subunit beta-3; Sodium/potassium-dependent ATPase subunit beta-3; ATPB-3; CD antigen CD298
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTKNEKKSLNQSLAEWKLFIYNPTTGEFLGRTAKSWGLILLFYLVFYGFLAALFSFTMWV
MLQTLNDEVPKYRDQIPSPGLMVFPKPVTALEYTFSRSDPTSYAGYIEDLKKFLKPYTLE
EQKNLTVCPDGALFEQKGPVYVACQFPISLLQACSGMNDPDFGYSQGNPCILVKMNRIIG
LKPEGVPRIDCVSKNEDIPNVAVYPHNGMIDLKYFPYYGKKLHVGYLQPLVAVQVSFAPN
NTGKEVTVECKIDGSANLKSQDDRDKFLGRVMFKITARA
Target Bioclass
Transporter and channel
Family
X(+)/potassium ATPases subunit beta family
Subcellular location
Apical cell membrane
Function
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known.
Uniprot ID
P54709
Ensemble ID
ENST00000286371.8
HGNC ID
HGNC:806
ChEMBL ID
CHEMBL2095186

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
MFE319 Insertion: p.L222TfsTer19 .
RKO SNV: p.I189M .
SW403 SNV: p.T101I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		3.49  LDD0318  [1]
CHEMBL5175495
 Probe Info  		8.06  LDD0196  [2]
TH216
 Probe Info  		Y21(8.14)  LDD0259  [3]
STPyne
 Probe Info  		K111(1.22); K182(5.29); K220(4.58); K266(8.58)  LDD0277  [4]
OPA-S-S-alkyne
 Probe Info  		K220(0.70); K266(2.22); K259(3.28); K182(5.21)  LDD3494  [5]
DBIA
 Probe Info  		C191(3.99)  LDD3323  [6]
THZ1-DTB
 Probe Info  		C154(1.00); C170(0.97)  LDD0460  [7]
BTD
 Probe Info  		C191(0.50)  LDD2089  [8]
5E-2FA
 Probe Info  		N.A.  LDD2235  [9]
ATP probe
 Probe Info  		K182(0.00); K111(0.00); K112(0.00)  LDD0199  [10]
m-APA
 Probe Info  		N.A.  LDD2231  [9]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [11]
Lodoacetamide azide
 Probe Info  		C250(0.00); C191(0.00)  LDD0037  [12]
1d-yne
 Probe Info  		N.A.  LDD0356  [13]
NHS
 Probe Info  		N.A.  LDD0010  [14]
TFBX
 Probe Info  		N.A.  LDD0148  [15]
Ox-W18
 Probe Info  		N.A.  LDD2175  [16]
1c-yne
 Probe Info  		K86(0.00); K17(0.00)  LDD0228  [13]
Acrolein
 Probe Info  		C250(0.00); C191(0.00)  LDD0217  [17]
Crotonaldehyde
 Probe Info  		C250(0.00); C191(0.00)  LDD0219  [17]
Methacrolein
 Probe Info  		C250(0.00); C191(0.00)  LDD0218  [17]
NAIA_5
 Probe Info  		N.A.  LDD2223  [18]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C289
 Probe Info  		25.28  LDD1959  [19]
FFF probe3
 Probe Info  		13.29  LDD0464  [20]
STS-2
 Probe Info  		N.A.  LDD0138  [21]
OEA-DA
 Probe Info  		3.17  LDD0046  [22]
STS-1
 Probe Info  		N.A.  LDD0068  [23]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C250(0.80)  LDD2112  [8]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C191(1.02)  LDD2095  [8]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C191(1.14); C250(0.89)  LDD2130  [8]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C191(1.04)  LDD2117  [8]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C191(0.69)  LDD2103  [8]
 LDCM0214  AC1 HEK-293T C128(1.10); C144(1.00); C170(0.91); C154(1.00)  LDD1507  [24]
 LDCM0215  AC10 HEK-293T C128(1.10); C144(1.19)  LDD1508  [24]
 LDCM0226  AC11 HEK-293T C128(1.05); C144(1.08)  LDD1509  [24]
 LDCM0237  AC12 HEK-293T C128(0.94); C144(1.03); C170(1.36)  LDD1510  [24]
 LDCM0259  AC14 HEK-293T C128(1.13); C250(1.07); C144(1.05)  LDD1512  [24]
 LDCM0270  AC15 HEK-293T C128(1.01); C250(1.06); C144(0.91); C170(0.94)  LDD1513  [24]
 LDCM0276  AC17 HEK-293T C128(0.93); C144(1.03); C170(0.70); C154(1.11)  LDD1515  [24]
 LDCM0277  AC18 HEK-293T C128(1.11); C144(1.04)  LDD1516  [24]
 LDCM0278  AC19 HEK-293T C128(1.13); C144(0.90)  LDD1517  [24]
 LDCM0279  AC2 HEK-293T C128(0.98); C144(1.14)  LDD1518  [24]
 LDCM0280  AC20 HEK-293T C128(1.00); C144(0.86); C170(1.09)  LDD1519  [24]
 LDCM0281  AC21 HEK-293T C128(1.04); C250(1.10); C144(0.90); C170(0.96)  LDD1520  [24]
 LDCM0282  AC22 HEK-293T C128(1.21); C250(0.93); C144(1.00)  LDD1521  [24]
 LDCM0283  AC23 HEK-293T C128(0.98); C250(0.98); C144(1.08); C170(0.92)  LDD1522  [24]
 LDCM0284  AC24 HEK-293T C128(0.83); C250(0.96); C144(0.95); C170(1.28)  LDD1523  [24]
 LDCM0285  AC25 HEK-293T C128(1.04); C144(0.86); C170(0.79); C154(0.97)  LDD1524  [24]
 LDCM0286  AC26 HEK-293T C128(0.87); C144(1.09)  LDD1525  [24]
 LDCM0287  AC27 HEK-293T C128(0.98); C144(0.98)  LDD1526  [24]
 LDCM0288  AC28 HEK-293T C128(0.97); C144(1.08); C170(1.01)  LDD1527  [24]
 LDCM0289  AC29 HEK-293T C128(1.00); C250(1.11); C144(1.07); C170(1.05)  LDD1528  [24]
 LDCM0290  AC3 HEK-293T C128(1.12); C144(1.32)  LDD1529  [24]
 LDCM0291  AC30 HEK-293T C128(1.04); C250(1.06); C144(1.16)  LDD1530  [24]
 LDCM0292  AC31 HEK-293T C128(1.00); C250(0.99); C144(0.98); C170(1.09)  LDD1531  [24]
 LDCM0293  AC32 HEK-293T C128(0.88); C250(1.05); C144(0.92); C170(1.13)  LDD1532  [24]
 LDCM0294  AC33 HEK-293T C128(0.94); C144(0.91); C170(1.35); C154(1.35)  LDD1533  [24]
 LDCM0295  AC34 HEK-293T C128(0.91); C144(1.04)  LDD1534  [24]
 LDCM0296  AC35 HEK-293T C128(1.03); C144(0.95)  LDD1535  [24]
 LDCM0297  AC36 HEK-293T C128(1.03); C144(0.82); C170(1.27)  LDD1536  [24]
 LDCM0298  AC37 HEK-293T C128(1.05); C250(1.10); C144(1.06); C170(1.00)  LDD1537  [24]
 LDCM0299  AC38 HEK-293T C128(1.05); C250(1.04); C144(1.11)  LDD1538  [24]
 LDCM0300  AC39 HEK-293T C128(1.11); C250(1.07); C144(1.10); C170(0.93)  LDD1539  [24]
 LDCM0301  AC4 HEK-293T C128(1.05); C144(0.96); C170(1.09)  LDD1540  [24]
 LDCM0302  AC40 HEK-293T C128(0.96); C250(0.91); C144(1.03); C170(0.96)  LDD1541  [24]
 LDCM0303  AC41 HEK-293T C128(1.09); C144(0.91); C170(0.95); C154(1.11)  LDD1542  [24]
 LDCM0304  AC42 HEK-293T C128(1.20); C144(1.13)  LDD1543  [24]
 LDCM0305  AC43 HEK-293T C128(1.03); C144(1.06)  LDD1544  [24]
 LDCM0306  AC44 HEK-293T C128(1.03); C144(0.96); C170(1.28)  LDD1545  [24]
 LDCM0307  AC45 HEK-293T C128(1.05); C250(0.95); C144(1.02); C170(0.96)  LDD1546  [24]
 LDCM0308  AC46 HEK-293T C128(1.18); C250(1.02); C144(1.21)  LDD1547  [24]
 LDCM0309  AC47 HEK-293T C128(1.02); C250(0.98); C144(0.88); C170(0.93)  LDD1548  [24]
 LDCM0310  AC48 HEK-293T C128(1.14); C250(1.15); C144(1.02); C170(0.99)  LDD1549  [24]
 LDCM0311  AC49 HEK-293T C128(1.01); C144(0.90); C170(0.72); C154(0.97)  LDD1550  [24]
 LDCM0312  AC5 HEK-293T C128(0.96); C250(1.10); C144(1.04); C170(1.00)  LDD1551  [24]
 LDCM0313  AC50 HEK-293T C128(1.04); C144(1.08)  LDD1552  [24]
 LDCM0314  AC51 HEK-293T C128(1.14); C144(1.13)  LDD1553  [24]
 LDCM0315  AC52 HEK-293T C128(1.04); C144(0.99); C170(0.98)  LDD1554  [24]
 LDCM0316  AC53 HEK-293T C128(1.02); C250(1.05); C144(0.90); C170(1.17)  LDD1555  [24]
 LDCM0317  AC54 HEK-293T C128(1.13); C250(0.97); C144(0.90)  LDD1556  [24]
 LDCM0318  AC55 HEK-293T C128(0.98); C250(1.02); C144(0.83); C170(1.01)  LDD1557  [24]
 LDCM0319  AC56 HEK-293T C128(0.97); C250(1.09); C144(0.93); C170(1.08)  LDD1558  [24]
 LDCM0320  AC57 HEK-293T C128(1.00); C144(0.87); C170(0.71); C154(1.06)  LDD1559  [24]
 LDCM0321  AC58 HEK-293T C128(1.10); C144(1.12)  LDD1560  [24]
 LDCM0322  AC59 HEK-293T C128(1.00); C144(1.11)  LDD1561  [24]
 LDCM0323  AC6 HEK-293T C128(1.14); C250(1.29); C144(1.19)  LDD1562  [24]
 LDCM0324  AC60 HEK-293T C128(0.92); C144(0.92); C170(1.11)  LDD1563  [24]
 LDCM0325  AC61 HEK-293T C128(0.99); C250(0.93); C144(1.07); C170(0.99)  LDD1564  [24]
 LDCM0326  AC62 HEK-293T C128(1.01); C250(1.08); C144(1.16)  LDD1565  [24]
 LDCM0327  AC63 HEK-293T C128(1.04); C250(0.97); C144(0.92); C170(1.03)  LDD1566  [24]
 LDCM0328  AC64 HEK-293T C128(1.03); C250(1.24); C144(1.08); C170(1.21)  LDD1567  [24]
 LDCM0334  AC7 HEK-293T C128(1.01); C250(1.04); C144(1.30); C170(0.89)  LDD1568  [24]
 LDCM0345  AC8 HEK-293T C128(0.88); C250(1.04); C144(1.04); C170(1.58)  LDD1569  [24]
 LDCM0545  Acetamide MDA-MB-231 C191(0.64)  LDD2138  [8]
 LDCM0520  AKOS000195272 MDA-MB-231 C191(0.93)  LDD2113  [8]
 LDCM0248  AKOS034007472 HEK-293T C128(1.07); C250(1.03); C144(0.97); C170(0.97)  LDD1511  [24]
 LDCM0356  AKOS034007680 HEK-293T C128(1.00); C144(0.90); C170(0.76); C154(1.08)  LDD1570  [24]
 LDCM0275  AKOS034007705 HEK-293T C128(0.98); C250(1.12); C144(1.02); C170(0.97)  LDD1514  [24]
 LDCM0498  BS-3668 MDA-MB-231 C250(1.37)  LDD2091  [8]
 LDCM0108  Chloroacetamide HeLa C191(0.00); C250(0.00)  LDD0222  [17]
 LDCM0367  CL1 HEK-293T C144(1.09)  LDD1571  [24]
 LDCM0368  CL10 HEK-293T C128(1.35); C250(1.24); C144(0.87)  LDD1572  [24]
 LDCM0369  CL100 HEK-293T C128(1.15); C144(0.92)  LDD1573  [24]
 LDCM0370  CL101 HEK-293T C144(1.14)  LDD1574  [24]
 LDCM0371  CL102 HEK-293T C128(1.20); C144(0.65); C170(1.13)  LDD1575  [24]
 LDCM0372  CL103 HEK-293T C128(1.19); C144(0.95); C154(1.18)  LDD1576  [24]
 LDCM0373  CL104 HEK-293T C128(1.16); C144(1.07)  LDD1577  [24]
 LDCM0374  CL105 HEK-293T C144(1.08)  LDD1578  [24]
 LDCM0375  CL106 HEK-293T C128(1.11); C144(0.95); C170(0.97)  LDD1579  [24]
 LDCM0376  CL107 HEK-293T C128(1.02); C144(1.05); C154(1.01)  LDD1580  [24]
 LDCM0377  CL108 HEK-293T C128(1.02); C144(1.32)  LDD1581  [24]
 LDCM0378  CL109 HEK-293T C144(1.22)  LDD1582  [24]
 LDCM0379  CL11 HEK-293T C128(1.08); C250(1.19); C144(0.71); C170(0.76)  LDD1583  [24]
 LDCM0380  CL110 HEK-293T C128(1.07); C144(1.08); C170(0.89)  LDD1584  [24]
 LDCM0381  CL111 HEK-293T C128(0.92); C144(1.10); C154(1.12)  LDD1585  [24]
 LDCM0382  CL112 HEK-293T C128(1.06); C144(0.83)  LDD1586  [24]
 LDCM0383  CL113 HEK-293T C144(0.89)  LDD1587  [24]
 LDCM0384  CL114 HEK-293T C128(1.13); C144(0.95); C170(1.32)  LDD1588  [24]
 LDCM0385  CL115 HEK-293T C128(1.13); C144(1.05); C154(1.20)  LDD1589  [24]
 LDCM0386  CL116 HEK-293T C128(1.15); C144(0.86)  LDD1590  [24]
 LDCM0387  CL117 HEK-293T C144(0.93)  LDD1591  [24]
 LDCM0388  CL118 HEK-293T C128(1.10); C144(1.21); C170(1.23)  LDD1592  [24]
 LDCM0389  CL119 HEK-293T C128(1.10); C144(1.36); C154(1.02)  LDD1593  [24]
 LDCM0390  CL12 HEK-293T C128(1.06); C250(1.34); C144(1.07); C170(0.91)  LDD1594  [24]
 LDCM0391  CL120 HEK-293T C128(1.12); C144(0.79)  LDD1595  [24]
 LDCM0392  CL121 HEK-293T C144(0.98)  LDD1596  [24]
 LDCM0393  CL122 HEK-293T C128(1.14); C144(0.80); C170(1.23)  LDD1597  [24]
 LDCM0394  CL123 HEK-293T C128(1.17); C144(1.12); C154(0.99)  LDD1598  [24]
 LDCM0395  CL124 HEK-293T C128(1.21); C144(1.13)  LDD1599  [24]
 LDCM0396  CL125 HEK-293T C144(1.35)  LDD1600  [24]
 LDCM0397  CL126 HEK-293T C128(1.26); C144(0.91); C170(1.14)  LDD1601  [24]
 LDCM0398  CL127 HEK-293T C128(1.08); C144(1.21); C154(1.22)  LDD1602  [24]
 LDCM0399  CL128 HEK-293T C128(1.03); C144(0.95)  LDD1603  [24]
 LDCM0400  CL13 HEK-293T C144(0.99)  LDD1604  [24]
 LDCM0401  CL14 HEK-293T C128(1.26); C144(0.98); C170(0.98)  LDD1605  [24]
 LDCM0402  CL15 HEK-293T C128(1.17); C144(0.91); C154(0.87)  LDD1606  [24]
 LDCM0403  CL16 HEK-293T C128(1.24); C144(0.83)  LDD1607  [24]
 LDCM0404  CL17 HEK-293T C128(1.08); C144(0.77); C170(0.57); C154(0.81)  LDD1608  [24]
 LDCM0405  CL18 HEK-293T C128(1.11); C144(1.11)  LDD1609  [24]
 LDCM0406  CL19 HEK-293T C128(1.01); C144(0.96)  LDD1610  [24]
 LDCM0407  CL2 HEK-293T C128(1.04); C144(0.62); C170(0.91)  LDD1611  [24]
 LDCM0408  CL20 HEK-293T C128(0.93); C144(0.75); C170(0.89)  LDD1612  [24]
 LDCM0409  CL21 HEK-293T C128(1.10); C250(1.53); C144(0.84); C170(0.82)  LDD1613  [24]
 LDCM0410  CL22 HEK-293T C128(1.05); C250(1.10); C144(0.96)  LDD1614  [24]
 LDCM0411  CL23 HEK-293T C128(1.05); C250(1.25); C144(0.88); C170(0.77)  LDD1615  [24]
 LDCM0412  CL24 HEK-293T C128(1.24); C250(1.18); C144(0.88); C170(0.78)  LDD1616  [24]
 LDCM0413  CL25 HEK-293T C144(1.29)  LDD1617  [24]
 LDCM0414  CL26 HEK-293T C128(1.07); C144(1.08); C170(0.98)  LDD1618  [24]
 LDCM0415  CL27 HEK-293T C128(1.00); C144(1.15); C154(0.96)  LDD1619  [24]
 LDCM0416  CL28 HEK-293T C128(1.13); C144(0.77)  LDD1620  [24]
 LDCM0417  CL29 HEK-293T C128(1.02); C144(0.96); C170(0.78); C154(1.24)  LDD1621  [24]
 LDCM0418  CL3 HEK-293T C128(1.11); C144(0.73); C154(0.88)  LDD1622  [24]
 LDCM0419  CL30 HEK-293T C128(0.93); C144(1.02)  LDD1623  [24]
 LDCM0420  CL31 HEK-293T C128(1.01); C144(0.79)  LDD1624  [24]
 LDCM0421  CL32 HEK-293T C128(1.01); C144(0.82); C170(0.83)  LDD1625  [24]
 LDCM0422  CL33 HEK-293T C128(1.16); C250(1.22); C144(0.85); C170(0.71)  LDD1626  [24]
 LDCM0423  CL34 HEK-293T C128(1.11); C250(1.03); C144(0.88)  LDD1627  [24]
 LDCM0424  CL35 HEK-293T C128(1.04); C250(1.35); C144(0.71); C170(0.79)  LDD1628  [24]
 LDCM0425  CL36 HEK-293T C128(1.10); C250(1.15); C144(0.86); C170(0.80)  LDD1629  [24]
 LDCM0426  CL37 HEK-293T C144(0.75)  LDD1630  [24]
 LDCM0428  CL39 HEK-293T C128(0.98); C144(0.95); C154(0.96)  LDD1632  [24]
 LDCM0429  CL4 HEK-293T C128(1.05); C144(0.79)  LDD1633  [24]
 LDCM0430  CL40 HEK-293T C128(0.96); C144(0.76)  LDD1634  [24]
 LDCM0431  CL41 HEK-293T C128(0.97); C144(0.93); C170(0.82); C154(1.10)  LDD1635  [24]
 LDCM0432  CL42 HEK-293T C128(1.14); C144(1.08)  LDD1636  [24]
 LDCM0433  CL43 HEK-293T C128(0.96); C144(0.90)  LDD1637  [24]
 LDCM0434  CL44 HEK-293T C128(0.92); C144(0.94); C170(0.87)  LDD1638  [24]
 LDCM0435  CL45 HEK-293T C128(1.16); C250(1.08); C144(0.84); C170(0.88)  LDD1639  [24]
 LDCM0436  CL46 HEK-293T C128(1.19); C250(1.30); C144(0.88)  LDD1640  [24]
 LDCM0437  CL47 HEK-293T C128(1.09); C250(1.07); C144(0.85); C170(0.92)  LDD1641  [24]
 LDCM0438  CL48 HEK-293T C128(0.99); C250(1.18); C144(0.81); C170(0.88)  LDD1642  [24]
 LDCM0439  CL49 HEK-293T C144(1.57)  LDD1643  [24]
 LDCM0440  CL5 HEK-293T C128(0.90); C144(0.86); C170(0.65); C154(0.95)  LDD1644  [24]
 LDCM0441  CL50 HEK-293T C128(1.07); C144(0.79); C170(1.08)  LDD1645  [24]
 LDCM0443  CL52 HEK-293T C128(1.11); C144(0.81)  LDD1646  [24]
 LDCM0444  CL53 HEK-293T C128(1.10); C144(0.77); C170(0.87); C154(1.03)  LDD1647  [24]
 LDCM0445  CL54 HEK-293T C128(1.17); C144(0.91)  LDD1648  [24]
 LDCM0446  CL55 HEK-293T C128(1.19); C144(1.02)  LDD1649  [24]
 LDCM0447  CL56 HEK-293T C128(1.14); C144(0.97); C170(1.17)  LDD1650  [24]
 LDCM0448  CL57 HEK-293T C128(1.12); C250(1.03); C144(0.80); C170(0.85)  LDD1651  [24]
 LDCM0449  CL58 HEK-293T C128(1.02); C250(1.21); C144(0.90)  LDD1652  [24]
 LDCM0450  CL59 HEK-293T C128(1.12); C250(1.22); C144(0.83); C170(1.18)  LDD1653  [24]
 LDCM0451  CL6 HEK-293T C128(1.09); C144(1.04)  LDD1654  [24]
 LDCM0452  CL60 HEK-293T C128(1.05); C250(1.20); C144(0.90); C170(0.83)  LDD1655  [24]
 LDCM0453  CL61 HEK-293T C144(1.23)  LDD1656  [24]
 LDCM0454  CL62 HEK-293T C128(1.19); C144(0.85); C170(1.08)  LDD1657  [24]
 LDCM0455  CL63 HEK-293T C128(1.10); C144(1.21); C154(1.05)  LDD1658  [24]
 LDCM0456  CL64 HEK-293T C128(1.07); C144(0.88)  LDD1659  [24]
 LDCM0457  CL65 HEK-293T C128(0.94); C144(0.87); C170(0.77); C154(1.10)  LDD1660  [24]
 LDCM0458  CL66 HEK-293T C128(0.90); C144(1.11)  LDD1661  [24]
 LDCM0459  CL67 HEK-293T C128(1.13); C144(1.09)  LDD1662  [24]
 LDCM0460  CL68 HEK-293T C128(1.03); C144(1.02); C170(0.97)  LDD1663  [24]
 LDCM0461  CL69 HEK-293T C128(0.99); C250(1.24); C144(0.96); C170(0.86)  LDD1664  [24]
 LDCM0462  CL7 HEK-293T C128(1.05); C144(0.92)  LDD1665  [24]
 LDCM0463  CL70 HEK-293T C128(1.10); C250(1.30); C144(0.92)  LDD1666  [24]
 LDCM0464  CL71 HEK-293T C128(1.16); C250(1.26); C144(0.94); C170(0.98)  LDD1667  [24]
 LDCM0465  CL72 HEK-293T C128(1.03); C250(1.16); C144(0.88); C170(0.76)  LDD1668  [24]
 LDCM0466  CL73 HEK-293T C144(1.18)  LDD1669  [24]
 LDCM0467  CL74 HEK-293T C128(1.05); C144(1.03); C170(1.01)  LDD1670  [24]
 LDCM0469  CL76 HEK-293T C128(1.12); C144(1.05)  LDD1672  [24]
 LDCM0470  CL77 HEK-293T C128(1.02); C144(0.93); C170(0.72); C154(0.95)  LDD1673  [24]
 LDCM0471  CL78 HEK-293T C128(1.06); C144(1.11)  LDD1674  [24]
 LDCM0472  CL79 HEK-293T C128(1.08); C144(0.99)  LDD1675  [24]
 LDCM0473  CL8 HEK-293T C128(1.20); C144(0.72); C170(0.81)  LDD1676  [24]
 LDCM0474  CL80 HEK-293T C128(0.99); C144(0.92); C170(1.14)  LDD1677  [24]
 LDCM0475  CL81 HEK-293T C128(1.17); C250(1.41); C144(0.96); C170(1.06)  LDD1678  [24]
 LDCM0476  CL82 HEK-293T C128(1.25); C250(1.19); C144(1.10)  LDD1679  [24]
 LDCM0477  CL83 HEK-293T C128(1.20); C250(1.02); C144(1.02); C170(0.85)  LDD1680  [24]
 LDCM0478  CL84 HEK-293T C128(0.96); C250(1.27); C144(1.02); C170(0.97)  LDD1681  [24]
 LDCM0479  CL85 HEK-293T C144(1.32)  LDD1682  [24]
 LDCM0480  CL86 HEK-293T C128(1.21); C144(1.49); C170(1.39)  LDD1683  [24]
 LDCM0481  CL87 HEK-293T C128(1.06); C144(1.14); C154(1.05)  LDD1684  [24]
 LDCM0482  CL88 HEK-293T C128(1.13); C144(0.86)  LDD1685  [24]
 LDCM0483  CL89 HEK-293T C128(1.00); C144(0.95); C170(0.69); C154(1.11)  LDD1686  [24]
 LDCM0484  CL9 HEK-293T C128(1.04); C250(1.28); C144(0.90); C170(1.00)  LDD1687  [24]
 LDCM0485  CL90 HEK-293T C128(1.18); C144(0.95)  LDD1688  [24]
 LDCM0486  CL91 HEK-293T C128(1.10); C144(1.11)  LDD1689  [24]
 LDCM0487  CL92 HEK-293T C128(1.01); C144(0.91); C170(0.89)  LDD1690  [24]
 LDCM0488  CL93 HEK-293T C128(1.06); C250(1.16); C144(1.02); C170(0.83)  LDD1691  [24]
 LDCM0489  CL94 HEK-293T C128(1.10); C250(1.19); C144(0.97)  LDD1692  [24]
 LDCM0490  CL95 HEK-293T C128(1.14); C250(1.10); C144(0.72); C170(0.89)  LDD1693  [24]
 LDCM0491  CL96 HEK-293T C128(1.11); C250(1.14); C144(0.92); C170(0.92)  LDD1694  [24]
 LDCM0492  CL97 HEK-293T C144(1.15)  LDD1695  [24]
 LDCM0493  CL98 HEK-293T C128(1.12); C144(0.66); C170(0.85)  LDD1696  [24]
 LDCM0494  CL99 HEK-293T C128(1.14); C144(1.08); C154(1.00)  LDD1697  [24]
 LDCM0495  E2913 HEK-293T C128(1.07); C144(1.00); C154(1.06)  LDD1698  [24]
 LDCM0468  Fragment33 HEK-293T C128(1.16); C144(1.40); C154(1.15)  LDD1671  [24]
 LDCM0427  Fragment51 HEK-293T C128(1.10); C144(1.06); C170(1.19)  LDD1631  [24]
 LDCM0107  IAA HeLa C191(0.00); C250(0.00)  LDD0221  [17]
 LDCM0022  KB02 HEK-293T C128(1.23); C144(1.06)  LDD1492  [24]
 LDCM0023  KB03 HEK-293T C128(1.74); C144(0.94)  LDD1497  [24]
 LDCM0024  KB05 SKMEL24 C191(3.99)  LDD3323  [6]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C191(0.67)  LDD2102  [8]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C191(0.50)  LDD2089  [8]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C191(1.15)  LDD2090  [8]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C191(1.17)  LDD2097  [8]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C191(0.90)  LDD2098  [8]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C191(0.70); C250(0.53)  LDD2100  [8]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C191(0.86)  LDD2101  [8]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C191(0.73); C250(0.54)  LDD2104  [8]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C250(0.56)  LDD2106  [8]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C191(0.69); C250(0.52)  LDD2108  [8]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C250(0.76)  LDD2110  [8]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C191(0.60); C250(0.61)  LDD2114  [8]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C191(0.76)  LDD2120  [8]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C191(0.55)  LDD2133  [8]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C191(1.09)  LDD2140  [8]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C191(0.88); C250(0.98)  LDD2141  [8]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C250(2.54)  LDD2147  [8]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C191(0.63)  LDD2148  [8]
 LDCM0021  THZ1 HeLa S3 C154(1.00); C170(0.97)  LDD0460  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Stomatin (STOM) Band 7/mec-2 family P27105
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cortexin-3 (CTXN3) Cortexin family Q4LDR2
Small cell adhesion glycoprotein (SMAGP) SMAGP family Q0VAQ4
Transmembrane protein 98 (TMEM98) TMEM98 family Q9Y2Y6

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Bisacodyl . DB09020

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
7 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
16 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
18 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
19 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
20 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
21 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
22 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
23 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
24 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402