Details of the Target

General Information of Target

Target ID LDTP03211
Target Name Integrin alpha-6 (ITGA6)
Gene Name ITGA6
Gene ID 3655
Synonyms
Integrin alpha-6; CD49 antigen-like family member F; VLA-6; CD antigen CD49f) [Cleaved into: Integrin alpha-6 heavy chain; Integrin alpha-6 light chain; Processed integrin alpha-6; Alpha6p)]
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAAAGQLCLLYLSAGLLSRLGAAFNLDTREDNVIRKYGDPGSLFGFSLAMHWQLQPEDKR
LLLVGAPRAEALPLQRANRTGGLYSCDITARGPCTRIEFDNDADPTSESKEDQWMGVTVQ
SQGPGGKVVTCAHRYEKRQHVNTKQESRDIFGRCYVLSQNLRIEDDMDGGDWSFCDGRLR
GHEKFGSCQQGVAATFTKDFHYIVFGAPGTYNWKGIVRVEQKNNTFFDMNIFEDGPYEVG
GETEHDESLVPVPANSYLGLLFLTSVSYTDPDQFVYKTRPPREQPDTFPDVMMNSYLGFS
LDSGKGIVSKDEITFVSGAPRANHSGAVVLLKRDMKSAHLLPEHIFDGEGLASSFGYDVA
VVDLNKDGWQDIVIGAPQYFDRDGEVGGAVYVYMNQQGRWNNVKPIRLNGTKDSMFGIAV
KNIGDINQDGYPDIAVGAPYDDLGKVFIYHGSANGINTKPTQVLKGISPYFGYSIAGNMD
LDRNSYPDVAVGSLSDSVTIFRSRPVINIQKTITVTPNRIDLRQKTACGAPSGICLQVKS
CFEYTANPAGYNPSISIVGTLEAEKERRKSGLSSRVQFRNQGSEPKYTQELTLKRQKQKV
CMEETLWLQDNIRDKLRPIPITASVEIQEPSSRRRVNSLPEVLPILNSDEPKTAHIDVHF
LKEGCGDDNVCNSNLKLEYKFCTREGNQDKFSYLPIQKGVPELVLKDQKDIALEITVTNS
PSNPRNPTKDGDDAHEAKLIATFPDTLTYSAYRELRAFPEKQLSCVANQNGSQADCELGN
PFKRNSNVTFYLVLSTTEVTFDTPDLDINLKLETTSNQDNLAPITAKAKVVIELLLSVSG
VAKPSQVYFGGTVVGEQAMKSEDEVGSLIEYEFRVINLGKPLTNLGTATLNIQWPKEISN
GKWLLYLVKVESKGLEKVTCEPQKEINSLNLTESHNSRKKREITEKQIDDNRKFSLFAER
KYQTLNCSVNVNCVNIRCPLRGLDSKASLILRSRLWNSTFLEEYSKLNYLDILMRAFIDV
TAAAENIRLPNAGTQVRVTVFPSKTVAQYSGVPWWIILVAILAGILMLALLVFILWKCGF
FKRSRYDDSVPRYHAVRIRKEEREIKDEKYIDNLEKKQWITKWNENESYS
Target Type
Literature-reported
Target Bioclass
Transporter and channel
Family
Integrin alpha chain family
Subcellular location
Cell membrane
Function
Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling.
TTD ID
T69121
Uniprot ID
P23229
DrugMap ID
TT165T3
Ensemble ID
ENST00000409080.6
HGNC ID
HGNC:6142
ChEMBL ID
CHEMBL3716

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		4.05  LDD0324  [1]
STPyne
 Probe Info  		K1116(3.22); K1117(4.71); K144(8.33); K310(9.17)  LDD0277  [2]
IPM
 Probe Info  		N.A.  LDD0241  [3]
OPA-S-S-alkyne
 Probe Info  		K310(1.72); K127(1.74); K986(1.78); K946(2.37)  LDD3494  [4]
BTD
 Probe Info  		C131(2.22)  LDD1700  [5]
DBIA
 Probe Info  		C86(0.90); C665(0.83); C671(0.83)  LDD0531  [6]
IA-alkyne
 Probe Info  		C131(0.00); C188(0.00); C175(0.00); C86(0.00)  LDD0162  [7]
NAIA_4
 Probe Info  		N.A.  LDD2226  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C131(0.67)  LDD2095  [5]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C131(0.93)  LDD2117  [5]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C131(1.44)  LDD2152  [5]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C131(0.67)  LDD2132  [5]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C131(0.92)  LDD2131  [5]
 LDCM0214  AC1 HCT 116 C86(0.90); C665(0.83); C671(0.83)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C665(0.70); C671(0.70)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C86(1.42); C154(0.92); C528(0.70); C535(0.70)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C86(0.81); C154(0.48); C528(0.65); C535(0.65)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C86(1.12); C154(0.48); C528(0.63); C535(0.63)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C86(0.98); C154(0.53); C528(0.63); C535(0.63)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C86(0.74); C154(0.59); C528(0.56); C535(0.56)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C86(0.75); C154(0.66); C528(0.62); C535(0.62)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C86(1.06); C154(0.59); C528(0.57); C535(0.57)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C86(1.11); C154(0.63); C528(0.63); C535(0.68)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C86(0.51); C154(0.46); C528(0.58); C535(0.56)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C86(0.73); C154(0.68); C528(0.58); C535(0.59)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C665(0.68); C671(0.68)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C86(0.61); C154(0.45); C528(0.68); C535(0.66)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C86(0.67); C154(0.69); C528(0.60); C535(0.59)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C86(1.01); C154(0.67); C528(0.74); C535(0.78)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C86(0.80); C665(1.08); C671(1.08)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C86(1.01); C665(1.06); C671(1.06)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C86(0.79); C665(0.85); C671(0.85)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C86(0.63); C665(1.09); C671(1.09)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C86(0.56); C665(1.34); C671(1.34)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C86(0.54); C665(0.96); C671(0.96)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C86(0.49); C665(1.85); C671(1.85)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C665(0.82); C671(0.82)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C86(0.45); C665(1.07); C671(1.07)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C86(0.50); C665(1.93); C671(1.93)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C86(0.35); C665(1.22); C671(1.22)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C86(0.29); C665(1.70); C671(1.70)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C86(0.32); C665(1.34); C671(1.34)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C86(0.39); C665(1.13); C671(1.13)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C86(0.33); C665(1.08); C671(1.08)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C86(0.30); C665(1.05); C671(1.05)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C131(1.03); C528(0.75); C535(0.75); C665(0.84)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C131(0.93); C528(0.96); C535(0.96); C665(0.93)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C131(1.07); C528(0.89); C535(0.89); C665(0.93)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C131(1.09); C528(1.05); C535(1.05); C665(0.99)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C131(1.22); C528(0.85); C535(0.85); C665(0.77)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C131(1.05); C528(0.84); C535(0.84); C665(0.72)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C131(1.07); C528(0.87); C535(0.87); C665(0.69)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C131(0.97); C528(0.74); C535(0.74); C665(0.80)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C131(0.99); C528(0.78); C535(0.78); C665(0.76)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C131(1.05); C528(0.78); C535(0.78); C665(0.88)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C131(1.08); C528(0.69); C535(0.69); C665(0.61)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C131(1.21); C528(0.82); C535(0.82); C665(0.79)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C665(0.81); C671(0.81)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C131(0.94); C528(0.74); C535(0.74); C665(0.69)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C131(1.06); C528(0.79); C535(0.79); C665(0.90)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C131(1.11); C528(0.94); C535(0.94); C665(0.87)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C86(0.64); C665(0.64); C671(0.64)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C665(0.58); C671(0.58); C86(0.86)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C665(0.64); C671(0.64); C86(0.89)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C665(0.54); C671(0.54); C86(0.81)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C665(0.52); C671(0.52); C86(0.87)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C665(0.34); C671(0.34); C86(0.51)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C665(0.46); C671(0.46); C86(1.12)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C665(0.74); C671(0.74)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C665(0.70); C671(0.70); C86(1.58)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C665(0.68); C671(0.68); C86(1.02)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C665(0.51); C671(0.51); C86(0.54)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C665(0.31); C671(0.31); C86(0.58)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C86(1.06); C665(0.55); C671(0.55)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C86(1.14); C665(0.75); C671(0.75)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C86(1.77); C665(0.91); C671(0.91)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C86(1.36); C665(0.91); C671(0.91)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C665(0.99); C671(0.99); C175(1.15); C154(1.19)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C154(0.56); C665(0.85); C671(0.85); C175(1.21)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C154(0.81); C665(1.02); C671(1.02); C175(1.04)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C665(0.80); C671(0.80); C86(0.97)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C154(0.95); C175(0.96); C665(0.97); C671(0.97)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C665(0.95); C671(0.95); C175(0.95); C154(0.98)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C175(0.98); C154(1.00); C665(1.06); C671(1.06)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C175(0.94); C665(1.03); C671(1.03); C154(1.04)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C665(0.97); C671(0.97); C175(0.98); C154(1.17)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C131(0.60); C86(1.12)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C131(0.59); C86(1.14)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C131(0.53); C86(1.17)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C131(0.63); C86(1.10)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C131(0.69); C86(1.28)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C665(0.86); C671(0.86); C86(1.22)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C131(0.62); C86(0.99)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C131(0.70); C86(1.39)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C131(0.55); C86(1.21)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C131(0.66); C86(1.31)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C131(0.70); C86(1.18)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C86(0.80); C665(1.18); C671(1.18)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C86(0.83); C665(1.05); C671(1.05)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C86(1.06); C665(1.10); C671(1.10)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C665(1.06); C671(1.06); C86(1.08)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C86(0.94); C665(0.95); C671(0.95)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C665(0.76); C671(0.76); C86(1.23)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C86(0.95); C665(1.10); C671(1.10)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C86(0.90); C665(1.03); C671(1.03)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C86(0.86); C665(1.06); C671(1.06)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C86(1.01); C665(1.03); C671(1.03)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C86(0.81); C665(1.04); C671(1.04)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C86(0.88); C665(1.10); C671(1.10)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C154(0.84); C86(0.89); C665(1.06); C671(1.06)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C86(0.90); C665(1.03); C671(1.03); C154(1.37)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C665(1.14); C671(1.14); C154(1.18); C86(1.28)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C154(0.64); C86(0.68); C665(0.81); C671(0.81)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C665(0.71); C671(0.71); C86(1.11)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C154(0.79); C665(0.80); C671(0.80); C86(0.85)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C154(0.99); C86(1.17); C665(1.43); C671(1.43)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C154(0.82); C86(0.89); C665(1.06); C671(1.06)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C154(0.82); C86(0.88); C665(0.91); C671(0.91)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C154(0.73); C86(0.82); C665(0.99); C671(0.99)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C665(0.85); C671(0.85); C154(0.87); C86(0.91)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C665(0.57); C671(0.57); C86(0.82); C154(0.84)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C665(0.74); C671(0.74); C86(1.04)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C665(0.69); C671(0.69); C86(1.17)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C665(0.76); C671(0.76); C86(0.98)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C665(0.75); C671(0.75)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C665(0.71); C671(0.71); C86(1.17)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C665(0.87); C671(0.87); C86(1.11)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C665(0.64); C671(0.64); C86(0.99)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C665(0.80); C671(0.80); C86(0.98)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C665(0.75); C671(0.75); C86(1.01)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C665(0.63); C671(0.63); C86(0.64)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C665(0.61); C671(0.61); C86(0.66)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C86(0.35); C665(0.46); C671(0.46)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C665(0.83); C671(0.83); C154(1.04); C131(1.14)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C665(0.73); C671(0.73); C154(1.07); C131(1.11)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C665(0.80); C671(0.80)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C665(0.64); C671(0.64); C131(0.80); C154(1.09)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C665(0.70); C671(0.70); C154(1.09); C131(1.18)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C665(0.75); C671(0.75); C131(0.91); C154(1.24)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C665(0.46); C671(0.46); C131(0.60); C154(0.85)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C665(0.46); C671(0.46); C131(0.77); C154(0.87)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C665(0.35); C671(0.35); C131(0.52); C154(0.78)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C665(0.67); C671(0.67); C131(0.84); C154(1.01)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C665(0.70); C671(0.70); C131(0.87); C154(1.28)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C665(0.82); C671(0.82); C154(1.26); C131(1.30)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C665(0.71); C671(0.71); C154(1.22); C131(1.35)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C665(0.75); C671(0.75)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C665(0.71); C671(0.71); C131(0.96); C154(1.16)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C154(0.93); C665(0.98); C671(0.98); C131(1.01)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C665(0.17); C671(0.17); C131(0.54); C154(0.56)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C665(0.66); C671(0.66); C528(0.72); C535(0.72)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C665(0.69); C671(0.69); C528(0.84); C535(0.84)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C665(0.77); C671(0.77); C528(0.87); C535(0.87)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C665(0.80); C671(0.80); C528(0.96); C535(0.96)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C86(0.80); C665(1.01); C671(1.01); C528(1.25)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C665(0.93); C671(0.93); C86(1.10); C528(1.15)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C665(0.81); C671(0.81); C86(0.86); C528(0.99)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C528(0.95); C535(0.95); C175(1.28); C665(1.34)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C665(0.70); C671(0.70); C86(0.88); C528(0.89)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C665(0.82); C671(0.82); C528(0.97); C535(0.97)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C528(0.96); C535(0.96); C665(0.97); C671(0.97)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C86(0.60); C665(0.79); C671(0.79); C528(1.28)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C86(1.20); C665(1.23); C671(1.23); C528(1.63)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C665(0.86); C671(0.86); C528(1.14); C535(1.14)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C86(0.73); C665(0.77); C671(0.77); C528(1.04)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C154(0.21); C528(0.24); C535(0.24); C86(0.25)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C154(0.49); C665(0.69); C671(0.69); C528(0.72)  LDD0683  [6]
 LDCM0545  Acetamide MDA-MB-231 C131(0.60); C920(0.49)  LDD2138  [5]
 LDCM0520  AKOS000195272 MDA-MB-231 C131(1.53)  LDD2113  [5]
 LDCM0248  AKOS034007472 HCT 116 C665(0.89); C671(0.89)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C665(0.82); C671(0.82)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C665(0.54); C671(0.54)  LDD0592  [6]
 LDCM0020  ARS-1620 HCC44 C154(1.04); C86(0.97); C665(1.06); C671(1.06)  LDD2171  [6]
 LDCM0498  BS-3668 MDA-MB-231 C131(0.54)  LDD2091  [5]
 LDCM0367  CL1 HCT 116 C665(1.27); C671(1.74)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C665(0.92); C671(0.94)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C665(0.77); C671(0.77); C86(1.00)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C665(0.85); C671(0.85)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C665(0.89); C671(0.89)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C665(1.18); C671(1.18)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C665(0.97); C671(0.97)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C665(0.77); C671(0.77); C154(0.95); C175(1.20)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C665(0.71); C671(0.71); C154(0.86); C175(1.35)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C665(0.69); C671(0.69); C154(0.83); C175(1.32)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C154(0.77); C665(0.77); C671(0.77); C175(1.37)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C665(0.85); C671(0.85); C154(1.08); C175(1.52)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C665(0.85); C671(0.98)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C665(1.02); C671(1.02); C175(1.27); C154(1.27)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C665(1.09); C671(1.09); C154(1.14); C175(1.32)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C131(0.51); C86(1.00)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C131(0.52); C86(1.15)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C131(0.59); C86(1.35)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C131(0.64); C86(1.38)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C131(0.73); C86(1.32)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C86(0.74); C665(1.16); C671(1.16)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C86(0.90); C665(1.16); C671(1.16)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C86(0.91); C665(1.02); C671(1.02)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C665(0.78); C671(0.87)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C665(0.94); C671(0.94); C86(0.99)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C86(0.69); C154(0.99); C665(2.26); C671(2.26)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C154(0.78); C665(0.85); C671(0.85); C86(0.95)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C154(0.82); C665(1.03); C671(1.03); C86(1.11)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C86(0.80); C154(0.82); C665(0.87); C671(0.87)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C86(1.04); C665(1.10); C671(1.10)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C86(0.75); C665(0.99); C671(0.99)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C665(0.79); C671(0.79); C86(1.13)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C665(0.80); C671(0.80); C86(0.99)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C671(0.91); C665(0.92)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C665(0.99); C671(1.14)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C665(0.99); C671(1.24)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C154(0.58); C175(0.74); C528(0.90); C535(0.90)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C86(0.79); C154(0.87); C665(0.98); C671(0.98)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C86(0.76); C154(0.82); C175(0.84); C665(0.97)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C86(0.73); C154(0.92); C665(1.00); C671(1.00)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C665(1.26); C671(1.60)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C154(0.71); C665(0.80); C671(0.80); C131(0.90)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C86(0.47); C154(0.66); C665(0.83); C671(0.83)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C154(0.47); C86(0.60); C175(0.68); C665(0.70)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C175(0.68); C154(0.78); C665(0.88); C671(0.88)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C86(0.48); C154(0.58); C665(0.81); C671(0.81)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C86(0.68); C131(0.94); C154(0.80); C175(0.99)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C86(0.54); C131(0.96); C154(0.77); C175(1.36)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C86(0.92); C131(1.19); C154(0.61); C175(1.46)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C86(0.72); C131(1.07); C154(0.70); C175(1.22)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C86(0.54); C131(1.04); C154(0.78); C175(1.32)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C665(0.95); C671(1.17)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C86(0.99); C131(0.95); C154(1.11); C175(0.76)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C665(0.69); C671(0.63)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C665(0.72); C671(0.67)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C665(1.03); C671(0.95)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C665(0.76); C671(0.63)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C665(0.75); C671(0.60)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C665(0.84); C671(0.72)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C665(0.68); C671(0.57)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C665(0.81); C671(0.72)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C665(0.91); C671(1.23)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C665(0.74); C671(0.63)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C665(0.86); C671(0.74)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C665(0.63); C671(0.44)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C665(0.70); C671(0.56)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C665(0.76); C671(0.66)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C665(0.85); C671(0.71)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C175(0.84)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C175(0.67)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C175(0.54)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C175(1.19)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C665(0.88); C671(1.15)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C175(1.00)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C175(0.65)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C175(0.58)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C175(0.90)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C175(0.91)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C175(0.56)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C175(0.96)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C175(0.65)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C175(0.56)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C175(0.72)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C665(1.13); C671(1.38)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C175(0.66)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C175(1.28)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C175(1.48)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C175(1.28)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C175(1.31)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C175(1.41)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C175(1.31)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C175(1.10)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C175(1.46)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C175(1.27)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C665(0.91); C671(0.90)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C175(1.23)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C175(1.20)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C175(1.27)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C175(1.10)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C175(1.44)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C665(0.73); C671(0.73)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C665(0.86); C671(0.86)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C665(0.92); C671(0.92)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C665(0.66); C671(0.66)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C665(0.76); C671(0.80)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C665(0.79); C671(0.79)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C665(0.68); C671(0.68)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C665(0.60); C671(0.60)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C665(0.62); C671(0.62)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C665(0.55); C671(0.55)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C665(0.82); C671(0.82)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C665(1.03); C671(1.03)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C665(0.95); C671(0.95)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C665(0.63); C671(0.63)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C665(0.43); C671(0.43)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C665(0.88); C671(0.95)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C665(1.12); C671(1.12)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C86(1.71); C665(0.94); C671(0.94)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C86(2.10); C665(0.98); C671(0.98)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C86(1.44); C665(1.17); C671(1.17)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C86(1.27); C665(0.87); C671(0.87)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C86(1.81); C665(0.88); C671(0.88)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C86(1.58); C665(1.07); C671(1.07)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C86(1.09); C665(0.80); C671(0.80)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C86(1.30); C665(0.71); C671(0.71)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C86(1.25); C665(0.76); C671(0.76)  LDD0811  [6]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C131(2.28); C188(1.97); C154(1.46); C86(1.11)  LDD1702  [5]
 LDCM0086  EN4 231MFP C175(3.95)  LDD0194  [9]
 LDCM0468  Fragment33 HCT 116 C175(1.27)  LDD0785  [6]
 LDCM0427  Fragment51 HCT 116 C665(0.76); C671(0.62)  LDD0744  [6]
 LDCM0022  KB02 769-P C17(2.81)  LDD2246  [10]
 LDCM0023  KB03 MDA-MB-231 C920(2.74); C131(2.34); C188(2.14)  LDD1701  [5]
 LDCM0024  KB05 COLO792 C40(3.01); C74(3.91); C86(2.65); C17(3.67)  LDD3310  [10]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C131(0.69)  LDD2121  [5]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C131(0.76)  LDD2089  [5]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C131(1.18)  LDD2093  [5]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C131(2.03)  LDD2094  [5]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C131(1.45)  LDD2097  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C131(1.53)  LDD2099  [5]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C131(2.54)  LDD2101  [5]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C920(1.16)  LDD2104  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C131(1.12); C920(0.90)  LDD2107  [5]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C920(0.98)  LDD2108  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C920(0.67)  LDD2109  [5]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C131(0.97)  LDD2111  [5]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C131(1.04)  LDD2115  [5]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C131(1.41)  LDD2119  [5]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C131(0.70)  LDD2120  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C131(0.83); C188(1.13)  LDD2123  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C131(0.68); C920(0.72)  LDD2125  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C131(0.83); C920(1.05)  LDD2127  [5]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C131(0.65)  LDD2128  [5]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C131(1.10)  LDD2129  [5]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C131(0.94)  LDD2133  [5]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C131(1.11)  LDD2134  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C131(1.05)  LDD2135  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C131(1.08)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C131(0.89); C920(0.76)  LDD2137  [5]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C131(2.22)  LDD1700  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C131(1.00); C920(0.64)  LDD2140  [5]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C920(0.85)  LDD2141  [5]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C131(0.61)  LDD2143  [5]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C131(1.99)  LDD2144  [5]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C920(1.61)  LDD2145  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C131(0.99)  LDD2146  [5]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C131(0.89)  LDD2147  [5]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C131(0.86); C920(0.59)  LDD2148  [5]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C131(0.54)  LDD2150  [5]
 LDCM0021  THZ1 HCT 116 C154(1.04); C86(0.97); C665(1.06); C671(1.06)  LDD2173  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Integrin beta-4 (ITGB4) Integrin beta chain family P16144

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Discovery of a Functional Covalent Ligand Targeting an Intrinsically Disordered Cysteine within MYC. Cell Chem Biol. 2021 Jan 21;28(1):4-13.e17. doi: 10.1016/j.chembiol.2020.09.001. Epub 2020 Sep 22.
10 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840