Details of the Target

General Information of Target

Target ID LDTP13579
Target Name Cip1-interacting zinc finger protein (CIZ1)
Gene Name CIZ1
Gene ID 25792
Synonyms
LSFR1; NP94; ZNF356; Cip1-interacting zinc finger protein; CDKN1A-interacting zinc finger protein 1; Nuclear protein NP94; Zinc finger protein 356
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAWRGAGPSVPGAPGGVGLSLGLLLQLLLLLGPARGFGDEEERRCDPIRISMCQNLGYNV
TKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCGGM
CLSVKRRCEPVLKEFGFAWPESLNCSKFPPQNDHNHMCMEGPGDEEVPLPHKTPIQPGEE
CHSVGTNSDQYIWVKRSLNCVLKCGYDAGLYSRSAKEFTDIWMAVWASLCFISTAFTVLT
FLIDSSRFSYPERPIIFLSMCYNIYSIAYIVRLTVGRERISCDFEEAAEPVLIQEGLKNT
GCAIIFLLMYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTI
VILIMRLVDADELTGLCYVGNQNLDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRSNL
QKDGTKTDKLERLMVKIGVFSVLYTVPATCVIACYFYEISNWALFRYSADDSNMAVEMLK
IFMSLLVGITSGMWIWSAKTLHTWQKCSNRLVNSGKVKREKRGNGWVKPGKGSETVV
Target Bioclass
Other
Subcellular location
Nucleus
Function May regulate the subcellular localization of CIP/WAF1.
Uniprot ID
Q9ULV3
Ensemble ID
ENST00000372938.10
HGNC ID
HGNC:16744

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.E213Q .
CAL51 SNV: p.T461A DBIA    Probe Info 
JHH7 Substitution: p.Q342_K343delinsHL .
MDST8 SNV: p.F311L .
NUGC3 SNV: p.Q374L .
PF382 SNV: p.E757G .
REH SNV: p.P204H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y596(5.81)  LDD0257  [2]
BTD
 Probe Info  		C848(1.57)  LDD2092  [3]
YY4-yne
 Probe Info  		2.72  LDD0400  [4]
AHL-Pu-1
 Probe Info  		C252(3.75)  LDD0168  [5]
EA-probe
 Probe Info  		N.A.  LDD0440  [6]
DBIA
 Probe Info  		C524(3.74); C531(3.74)  LDD0080  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [8]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [9]
NAIA_4
 Probe Info  		C252(0.00); C631(0.00)  LDD2226  [10]
TFBX
 Probe Info  		N.A.  LDD0027  [11]
WYneN
 Probe Info  		N.A.  LDD0021  [12]
IPM
 Probe Info  		C631(0.00); C848(0.00)  LDD0005  [12]
VSF
 Probe Info  		N.A.  LDD0007  [12]
Phosphinate-6
 Probe Info  		C234(0.00); C848(0.00); C252(0.00); C631(0.00)  LDD0018  [13]
Acrolein
 Probe Info  		N.A.  LDD0217  [14]
Methacrolein
 Probe Info  		N.A.  LDD0218  [14]
AOyne
 Probe Info  		15.00  LDD0443  [15]
NAIA_5
 Probe Info  		C602(0.00); C819(0.00); C631(0.00)  LDD2223  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C252(3.75)  LDD0168  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C252(9.03)  LDD0169  [5]
 LDCM0214  AC1 HEK-293T C524(0.75); C531(0.75)  LDD0812  [7]
 LDCM0215  AC10 HEK-293T C524(0.90); C531(0.90)  LDD0813  [7]
 LDCM0216  AC100 HEK-293T C524(0.98); C531(0.98)  LDD0814  [7]
 LDCM0217  AC101 HEK-293T C524(0.93); C531(0.93)  LDD0815  [7]
 LDCM0218  AC102 HEK-293T C524(0.95); C531(0.95)  LDD0816  [7]
 LDCM0219  AC103 HEK-293T C524(1.03); C531(1.03)  LDD0817  [7]
 LDCM0220  AC104 HEK-293T C524(0.99); C531(0.99)  LDD0818  [7]
 LDCM0221  AC105 HEK-293T C524(0.94); C531(0.94)  LDD0819  [7]
 LDCM0222  AC106 HEK-293T C524(1.32); C531(1.32)  LDD0820  [7]
 LDCM0223  AC107 HEK-293T C524(0.90); C531(0.90)  LDD0821  [7]
 LDCM0224  AC108 HEK-293T C524(0.96); C531(0.96)  LDD0822  [7]
 LDCM0225  AC109 HEK-293T C524(0.97); C531(0.97)  LDD0823  [7]
 LDCM0226  AC11 HEK-293T C524(1.14); C531(1.14)  LDD0824  [7]
 LDCM0227  AC110 HEK-293T C524(1.11); C531(1.11)  LDD0825  [7]
 LDCM0228  AC111 HEK-293T C524(1.14); C531(1.14)  LDD0826  [7]
 LDCM0229  AC112 HEK-293T C524(1.01); C531(1.01)  LDD0827  [7]
 LDCM0237  AC12 HEK-293T C524(0.92); C531(0.92)  LDD0835  [7]
 LDCM0246  AC128 HEK-293T C524(1.11); C531(1.11)  LDD0844  [7]
 LDCM0247  AC129 HEK-293T C524(0.99); C531(0.99)  LDD0845  [7]
 LDCM0249  AC130 HEK-293T C524(1.24); C531(1.24)  LDD0847  [7]
 LDCM0250  AC131 HEK-293T C524(1.12); C531(1.12)  LDD0848  [7]
 LDCM0251  AC132 HEK-293T C524(1.12); C531(1.12)  LDD0849  [7]
 LDCM0252  AC133 HEK-293T C524(1.17); C531(1.17)  LDD0850  [7]
 LDCM0253  AC134 HEK-293T C524(1.17); C531(1.17)  LDD0851  [7]
 LDCM0254  AC135 HEK-293T C524(1.02); C531(1.02)  LDD0852  [7]
 LDCM0255  AC136 HEK-293T C524(1.15); C531(1.15)  LDD0853  [7]
 LDCM0256  AC137 HEK-293T C524(1.05); C531(1.05)  LDD0854  [7]
 LDCM0257  AC138 HEK-293T C524(1.04); C531(1.04)  LDD0855  [7]
 LDCM0258  AC139 HEK-293T C524(1.13); C531(1.13)  LDD0856  [7]
 LDCM0259  AC14 HEK-293T C524(0.91); C531(0.91)  LDD0857  [7]
 LDCM0260  AC140 HEK-293T C524(1.09); C531(1.09)  LDD0858  [7]
 LDCM0261  AC141 HEK-293T C524(1.09); C531(1.09)  LDD0859  [7]
 LDCM0262  AC142 HEK-293T C524(1.07); C531(1.07)  LDD0860  [7]
 LDCM0263  AC143 HEK-293T C524(0.77); C531(0.77)  LDD0861  [7]
 LDCM0264  AC144 HEK-293T C524(0.89); C531(0.89)  LDD0862  [7]
 LDCM0265  AC145 HEK-293T C524(0.92); C531(0.92)  LDD0863  [7]
 LDCM0266  AC146 HEK-293T C524(0.89); C531(0.89)  LDD0864  [7]
 LDCM0267  AC147 HEK-293T C524(0.97); C531(0.97)  LDD0865  [7]
 LDCM0268  AC148 HEK-293T C524(0.95); C531(0.95)  LDD0866  [7]
 LDCM0269  AC149 HEK-293T C524(1.09); C531(1.09)  LDD0867  [7]
 LDCM0270  AC15 HEK-293T C524(0.81); C531(0.81)  LDD0868  [7]
 LDCM0271  AC150 HEK-293T C524(0.95); C531(0.95)  LDD0869  [7]
 LDCM0272  AC151 HEK-293T C524(0.94); C531(0.94)  LDD0870  [7]
 LDCM0273  AC152 HEK-293T C524(0.87); C531(0.87)  LDD0871  [7]
 LDCM0274  AC153 HEK-293T C524(0.90); C531(0.90)  LDD0872  [7]
 LDCM0621  AC154 HEK-293T C524(0.91); C531(0.91)  LDD2162  [7]
 LDCM0622  AC155 HEK-293T C524(0.90); C531(0.90)  LDD2163  [7]
 LDCM0623  AC156 HEK-293T C524(0.91); C531(0.91)  LDD2164  [7]
 LDCM0624  AC157 HEK-293T C524(1.10); C531(1.10)  LDD2165  [7]
 LDCM0276  AC17 HEK-293T C524(0.73); C531(0.73)  LDD0874  [7]
 LDCM0277  AC18 HEK-293T C524(0.78); C531(0.78)  LDD0875  [7]
 LDCM0278  AC19 HEK-293T C524(0.74); C531(0.74)  LDD0876  [7]
 LDCM0279  AC2 HEK-293T C524(0.87); C531(0.87)  LDD0877  [7]
 LDCM0280  AC20 HEK-293T C524(0.70); C531(0.70)  LDD0878  [7]
 LDCM0281  AC21 HEK-293T C524(0.88); C531(0.88)  LDD0879  [7]
 LDCM0282  AC22 HEK-293T C524(0.64); C531(0.64)  LDD0880  [7]
 LDCM0283  AC23 HEK-293T C524(0.74); C531(0.74)  LDD0881  [7]
 LDCM0284  AC24 HEK-293T C524(0.73); C531(0.73)  LDD0882  [7]
 LDCM0285  AC25 HEK-293T C524(0.84); C531(0.84)  LDD0883  [7]
 LDCM0286  AC26 HEK-293T C524(0.81); C531(0.81)  LDD0884  [7]
 LDCM0287  AC27 HEK-293T C524(0.76); C531(0.76)  LDD0885  [7]
 LDCM0288  AC28 HEK-293T C524(0.95); C531(0.95)  LDD0886  [7]
 LDCM0289  AC29 HEK-293T C524(0.82); C531(0.82)  LDD0887  [7]
 LDCM0290  AC3 HEK-293T C524(0.87); C531(0.87)  LDD0888  [7]
 LDCM0291  AC30 HEK-293T C524(0.87); C531(0.87)  LDD0889  [7]
 LDCM0292  AC31 HEK-293T C524(0.91); C531(0.91)  LDD0890  [7]
 LDCM0293  AC32 HEK-293T C524(0.83); C531(0.83)  LDD0891  [7]
 LDCM0294  AC33 HEK-293T C524(0.87); C531(0.87)  LDD0892  [7]
 LDCM0295  AC34 HEK-293T C524(0.91); C531(0.91)  LDD0893  [7]
 LDCM0296  AC35 HEK-293T C252(1.12); C631(1.82); C234(1.32)  LDD1535  [16]
 LDCM0297  AC36 HEK-293T C252(1.28); C631(1.10); C819(1.00)  LDD1536  [16]
 LDCM0298  AC37 HEK-293T C252(1.04); C234(1.19); C819(1.11)  LDD1537  [16]
 LDCM0299  AC38 HEK-293T C252(1.09); C631(1.17); C819(1.04)  LDD1538  [16]
 LDCM0300  AC39 HEK-293T C252(1.17); C631(1.06); C234(1.26); C819(1.04)  LDD1539  [16]
 LDCM0301  AC4 HEK-293T C524(0.99); C531(0.99)  LDD0899  [7]
 LDCM0302  AC40 HEK-293T C252(1.02); C234(0.89); C819(1.05)  LDD1541  [16]
 LDCM0303  AC41 HEK-293T C252(1.26); C234(1.52)  LDD1542  [16]
 LDCM0304  AC42 HEK-293T C252(0.94); C631(1.13); C234(1.03)  LDD1543  [16]
 LDCM0305  AC43 HEK-293T C252(1.15); C631(0.92); C234(1.03)  LDD1544  [16]
 LDCM0306  AC44 HEK-293T C252(1.13); C631(1.06); C819(0.99)  LDD1545  [16]
 LDCM0307  AC45 HEK-293T C252(1.13); C234(1.09); C819(1.13)  LDD1546  [16]
 LDCM0308  AC46 HEK-293T C252(1.01); C631(1.22); C819(0.98)  LDD1547  [16]
 LDCM0309  AC47 HEK-293T C252(1.11); C631(1.10); C234(1.14); C819(1.02)  LDD1548  [16]
 LDCM0310  AC48 HEK-293T C252(1.11); C234(1.29); C819(1.05)  LDD1549  [16]
 LDCM0311  AC49 HEK-293T C252(1.17); C234(1.52)  LDD1550  [16]
 LDCM0312  AC5 HEK-293T C524(0.92); C531(0.92)  LDD0910  [7]
 LDCM0313  AC50 HEK-293T C252(1.01); C631(0.93); C234(1.09)  LDD1552  [16]
 LDCM0314  AC51 HEK-293T C252(1.08); C631(1.32); C234(1.01)  LDD1553  [16]
 LDCM0315  AC52 HEK-293T C252(1.20); C631(1.10); C819(1.04)  LDD1554  [16]
 LDCM0316  AC53 HEK-293T C252(1.08); C234(1.22); C819(1.16)  LDD1555  [16]
 LDCM0317  AC54 HEK-293T C252(1.16); C631(1.29); C819(1.10)  LDD1556  [16]
 LDCM0318  AC55 HEK-293T C252(1.17); C631(1.10); C234(1.72); C819(1.16)  LDD1557  [16]
 LDCM0319  AC56 HEK-293T C252(0.99); C234(0.93); C819(1.03)  LDD1558  [16]
 LDCM0320  AC57 HEK-293T C252(1.13); C234(1.22)  LDD1559  [16]
 LDCM0321  AC58 HEK-293T C252(0.95); C631(1.03); C234(0.90)  LDD1560  [16]
 LDCM0322  AC59 HEK-293T C252(1.05); C631(1.04); C234(0.94)  LDD1561  [16]
 LDCM0323  AC6 HEK-293T C524(0.89); C531(0.89)  LDD0921  [7]
 LDCM0324  AC60 HEK-293T C252(1.17); C631(1.03); C819(0.94)  LDD1563  [16]
 LDCM0325  AC61 HEK-293T C252(1.00); C234(0.98); C819(1.02)  LDD1564  [16]
 LDCM0326  AC62 HEK-293T C252(1.06); C631(1.10); C819(0.95)  LDD1565  [16]
 LDCM0327  AC63 HEK-293T C252(1.14); C631(1.09); C234(1.27); C819(0.97)  LDD1566  [16]
 LDCM0328  AC64 HEK-293T C252(1.08); C234(0.90); C819(1.03)  LDD1567  [16]
 LDCM0334  AC7 HEK-293T C524(0.91); C531(0.91)  LDD0932  [7]
 LDCM0345  AC8 HEK-293T C524(0.80); C531(0.80)  LDD0943  [7]
 LDCM0349  AC83 HEK-293T C524(1.03); C531(1.03)  LDD0947  [7]
 LDCM0350  AC84 HEK-293T C524(0.82); C531(0.82)  LDD0948  [7]
 LDCM0351  AC85 HEK-293T C524(0.87); C531(0.87)  LDD0949  [7]
 LDCM0352  AC86 HEK-293T C524(0.85); C531(0.85)  LDD0950  [7]
 LDCM0353  AC87 HEK-293T C524(0.85); C531(0.85)  LDD0951  [7]
 LDCM0354  AC88 HEK-293T C524(0.86); C531(0.86)  LDD0952  [7]
 LDCM0355  AC89 HEK-293T C524(0.72); C531(0.72)  LDD0953  [7]
 LDCM0357  AC90 HEK-293T C524(0.77); C531(0.77)  LDD0955  [7]
 LDCM0358  AC91 HEK-293T C524(0.86); C531(0.86)  LDD0956  [7]
 LDCM0359  AC92 HEK-293T C524(0.79); C531(0.79)  LDD0957  [7]
 LDCM0360  AC93 HEK-293T C524(0.82); C531(0.82)  LDD0958  [7]
 LDCM0361  AC94 HEK-293T C524(0.82); C531(0.82)  LDD0959  [7]
 LDCM0362  AC95 HEK-293T C524(0.78); C531(0.78)  LDD0960  [7]
 LDCM0363  AC96 HEK-293T C524(0.69); C531(0.69)  LDD0961  [7]
 LDCM0364  AC97 HEK-293T C524(0.67); C531(0.67)  LDD0962  [7]
 LDCM0365  AC98 HEK-293T C524(1.07); C531(1.07)  LDD0963  [7]
 LDCM0366  AC99 HEK-293T C524(0.91); C531(0.91)  LDD0964  [7]
 LDCM0248  AKOS034007472 HEK-293T C524(0.96); C531(0.96)  LDD0846  [7]
 LDCM0356  AKOS034007680 HEK-293T C524(0.84); C531(0.84)  LDD0954  [7]
 LDCM0275  AKOS034007705 HEK-293T C524(0.84); C531(0.84)  LDD0873  [7]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C524(1.13); C531(1.13)  LDD2171  [7]
 LDCM0632  CL-Sc Hep-G2 C819(0.36)  LDD2227  [10]
 LDCM0367  CL1 HEK-293T C252(0.92); C631(0.93); C234(0.87)  LDD1571  [16]
 LDCM0368  CL10 HEK-293T C252(0.89); C631(1.19); C819(1.13)  LDD1572  [16]
 LDCM0369  CL100 HEK-293T C524(0.82); C531(0.82)  LDD0967  [7]
 LDCM0370  CL101 HEK-293T C524(0.74); C531(0.74)  LDD0968  [7]
 LDCM0371  CL102 HEK-293T C524(0.74); C531(0.74)  LDD0969  [7]
 LDCM0372  CL103 HEK-293T C524(0.83); C531(0.83)  LDD0970  [7]
 LDCM0373  CL104 HEK-293T C524(0.80); C531(0.80)  LDD0971  [7]
 LDCM0374  CL105 HEK-293T C524(0.71); C531(0.71)  LDD0972  [7]
 LDCM0375  CL106 HEK-293T C524(0.72); C531(0.72)  LDD0973  [7]
 LDCM0376  CL107 HEK-293T C524(0.68); C531(0.68)  LDD0974  [7]
 LDCM0377  CL108 HEK-293T C524(0.72); C531(0.72)  LDD0975  [7]
 LDCM0378  CL109 HEK-293T C524(0.79); C531(0.79)  LDD0976  [7]
 LDCM0379  CL11 HEK-293T C252(1.08); C631(1.23); C234(1.07); C819(1.09)  LDD1583  [16]
 LDCM0380  CL110 HEK-293T C524(0.74); C531(0.74)  LDD0978  [7]
 LDCM0381  CL111 HEK-293T C524(0.65); C531(0.65)  LDD0979  [7]
 LDCM0382  CL112 HEK-293T C524(0.73); C531(0.73)  LDD0980  [7]
 LDCM0383  CL113 HEK-293T C524(0.92); C531(0.92)  LDD0981  [7]
 LDCM0384  CL114 HEK-293T C524(0.77); C531(0.77)  LDD0982  [7]
 LDCM0385  CL115 HEK-293T C524(0.83); C531(0.83)  LDD0983  [7]
 LDCM0386  CL116 HEK-293T C524(0.80); C531(0.80)  LDD0984  [7]
 LDCM0387  CL117 HEK-293T C252(1.04); C631(1.04); C234(1.02)  LDD1591  [16]
 LDCM0388  CL118 HEK-293T C252(1.01); C631(1.10)  LDD1592  [16]
 LDCM0389  CL119 HEK-293T C252(1.00); C631(0.85); C234(0.79); C801(1.08)  LDD1593  [16]
 LDCM0390  CL12 HEK-293T C252(1.02); C234(0.86); C819(1.02)  LDD1594  [16]
 LDCM0391  CL120 HEK-293T C252(1.09); C631(1.06); C234(0.94)  LDD1595  [16]
 LDCM0392  CL121 HEK-293T C252(1.06); C631(0.96); C234(1.13)  LDD1596  [16]
 LDCM0393  CL122 HEK-293T C252(1.10); C631(1.00)  LDD1597  [16]
 LDCM0394  CL123 HEK-293T C252(0.95); C631(0.95); C234(0.66); C801(0.91)  LDD1598  [16]
 LDCM0395  CL124 HEK-293T C252(1.01); C631(1.12); C234(1.18)  LDD1599  [16]
 LDCM0396  CL125 HEK-293T C252(0.93); C631(0.96); C234(0.82)  LDD1600  [16]
 LDCM0397  CL126 HEK-293T C252(0.98); C631(1.01)  LDD1601  [16]
 LDCM0398  CL127 HEK-293T C252(1.21); C631(0.91); C234(0.84); C801(0.82)  LDD1602  [16]
 LDCM0399  CL128 HEK-293T C252(1.04); C631(1.03); C234(1.03)  LDD1603  [16]
 LDCM0400  CL13 HEK-293T C252(1.09); C631(1.04); C234(0.95)  LDD1604  [16]
 LDCM0401  CL14 HEK-293T C252(0.94); C631(1.05)  LDD1605  [16]
 LDCM0402  CL15 HEK-293T C252(1.02); C631(1.04); C234(0.85); C801(1.08)  LDD1606  [16]
 LDCM0403  CL16 HEK-293T C252(1.05); C631(1.06); C234(0.83)  LDD1607  [16]
 LDCM0404  CL17 HEK-293T C252(1.00); C234(1.50)  LDD1608  [16]
 LDCM0405  CL18 HEK-293T C252(1.09); C631(0.99); C234(1.02)  LDD1609  [16]
 LDCM0406  CL19 HEK-293T C252(1.27); C631(0.99); C234(1.06)  LDD1610  [16]
 LDCM0407  CL2 HEK-293T C252(1.01); C631(1.08)  LDD1611  [16]
 LDCM0408  CL20 HEK-293T C252(1.36); C631(1.10); C819(1.09)  LDD1612  [16]
 LDCM0409  CL21 HEK-293T C252(1.03); C234(0.90); C819(1.04)  LDD1613  [16]
 LDCM0410  CL22 HEK-293T C252(1.32); C631(1.63); C819(1.30)  LDD1614  [16]
 LDCM0411  CL23 HEK-293T C252(1.26); C631(1.11); C234(1.42); C819(1.14)  LDD1615  [16]
 LDCM0412  CL24 HEK-293T C252(0.99); C234(1.28); C819(1.00)  LDD1616  [16]
 LDCM0413  CL25 HEK-293T C252(1.00); C631(0.90); C234(0.91)  LDD1617  [16]
 LDCM0414  CL26 HEK-293T C252(1.12); C631(0.94)  LDD1618  [16]
 LDCM0415  CL27 HEK-293T C252(1.16); C631(1.04); C234(1.49); C801(0.92)  LDD1619  [16]
 LDCM0416  CL28 HEK-293T C252(1.02); C631(1.15); C234(1.11)  LDD1620  [16]
 LDCM0417  CL29 HEK-293T C252(1.02); C234(1.42)  LDD1621  [16]
 LDCM0418  CL3 HEK-293T C252(1.03); C631(0.89); C234(0.52); C801(1.05)  LDD1622  [16]
 LDCM0419  CL30 HEK-293T C252(1.05); C631(1.00); C234(1.00)  LDD1623  [16]
 LDCM0420  CL31 HEK-293T C524(1.06); C531(1.06)  LDD1018  [7]
 LDCM0421  CL32 HEK-293T C524(1.13); C531(1.13)  LDD1019  [7]
 LDCM0422  CL33 HEK-293T C524(0.92); C531(0.92)  LDD1020  [7]
 LDCM0423  CL34 HEK-293T C524(1.13); C531(1.13)  LDD1021  [7]
 LDCM0424  CL35 HEK-293T C524(0.94); C531(0.94)  LDD1022  [7]
 LDCM0425  CL36 HEK-293T C524(1.02); C531(1.02)  LDD1023  [7]
 LDCM0426  CL37 HEK-293T C524(0.96); C531(0.96)  LDD1024  [7]
 LDCM0428  CL39 HEK-293T C524(1.01); C531(1.01)  LDD1026  [7]
 LDCM0429  CL4 HEK-293T C252(0.88); C631(0.99); C234(0.99)  LDD1633  [16]
 LDCM0430  CL40 HEK-293T C524(1.06); C531(1.06)  LDD1028  [7]
 LDCM0431  CL41 HEK-293T C524(1.05); C531(1.05)  LDD1029  [7]
 LDCM0432  CL42 HEK-293T C524(1.00); C531(1.00)  LDD1030  [7]
 LDCM0433  CL43 HEK-293T C524(0.96); C531(0.96)  LDD1031  [7]
 LDCM0434  CL44 HEK-293T C524(0.94); C531(0.94)  LDD1032  [7]
 LDCM0435  CL45 HEK-293T C524(0.78); C531(0.78)  LDD1033  [7]
 LDCM0436  CL46 HEK-293T C524(0.94); C531(0.94)  LDD1034  [7]
 LDCM0437  CL47 HEK-293T C524(0.77); C531(0.77)  LDD1035  [7]
 LDCM0438  CL48 HEK-293T C524(0.96); C531(0.96)  LDD1036  [7]
 LDCM0439  CL49 HEK-293T C524(0.96); C531(0.96)  LDD1037  [7]
 LDCM0440  CL5 HEK-293T C252(1.10); C234(1.33)  LDD1644  [16]
 LDCM0441  CL50 HEK-293T C524(1.10); C531(1.10)  LDD1039  [7]
 LDCM0442  CL51 HEK-293T C524(1.01); C531(1.01)  LDD1040  [7]
 LDCM0443  CL52 HEK-293T C524(0.98); C531(0.98)  LDD1041  [7]
 LDCM0444  CL53 HEK-293T C524(0.96); C531(0.96)  LDD1042  [7]
 LDCM0445  CL54 HEK-293T C524(0.84); C531(0.84)  LDD1043  [7]
 LDCM0446  CL55 HEK-293T C524(0.92); C531(0.92)  LDD1044  [7]
 LDCM0447  CL56 HEK-293T C524(0.85); C531(0.85)  LDD1045  [7]
 LDCM0448  CL57 HEK-293T C524(0.93); C531(0.93)  LDD1046  [7]
 LDCM0449  CL58 HEK-293T C524(1.04); C531(1.04)  LDD1047  [7]
 LDCM0450  CL59 HEK-293T C524(0.86); C531(0.86)  LDD1048  [7]
 LDCM0451  CL6 HEK-293T C252(0.93); C631(0.98); C234(0.91)  LDD1654  [16]
 LDCM0452  CL60 HEK-293T C524(1.03); C531(1.03)  LDD1050  [7]
 LDCM0453  CL61 HEK-293T C524(0.63); C531(0.63)  LDD1051  [7]
 LDCM0454  CL62 HEK-293T C524(0.77); C531(0.77)  LDD1052  [7]
 LDCM0455  CL63 HEK-293T C524(0.80); C531(0.80)  LDD1053  [7]
 LDCM0456  CL64 HEK-293T C524(0.84); C531(0.84)  LDD1054  [7]
 LDCM0457  CL65 HEK-293T C524(0.88); C531(0.88)  LDD1055  [7]
 LDCM0458  CL66 HEK-293T C524(0.91); C531(0.91)  LDD1056  [7]
 LDCM0459  CL67 HEK-293T C524(1.27); C531(1.27)  LDD1057  [7]
 LDCM0460  CL68 HEK-293T C524(0.94); C531(0.94)  LDD1058  [7]
 LDCM0461  CL69 HEK-293T C524(0.81); C531(0.81)  LDD1059  [7]
 LDCM0462  CL7 HEK-293T C252(1.08); C631(1.03); C234(1.05)  LDD1665  [16]
 LDCM0463  CL70 HEK-293T C524(0.97); C531(0.97)  LDD1061  [7]
 LDCM0464  CL71 HEK-293T C524(0.75); C531(0.75)  LDD1062  [7]
 LDCM0465  CL72 HEK-293T C524(0.96); C531(0.96)  LDD1063  [7]
 LDCM0466  CL73 HEK-293T C524(0.87); C531(0.87)  LDD1064  [7]
 LDCM0467  CL74 HEK-293T C524(0.93); C531(0.93)  LDD1065  [7]
 LDCM0469  CL76 HEK-293T C524(1.15); C531(1.15)  LDD1067  [7]
 LDCM0470  CL77 HEK-293T C524(0.90); C531(0.90)  LDD1068  [7]
 LDCM0471  CL78 HEK-293T C524(0.72); C531(0.72)  LDD1069  [7]
 LDCM0472  CL79 HEK-293T C524(0.74); C531(0.74)  LDD1070  [7]
 LDCM0473  CL8 HEK-293T C252(0.78); C631(1.25); C819(0.94)  LDD1676  [16]
 LDCM0474  CL80 HEK-293T C524(0.85); C531(0.85)  LDD1072  [7]
 LDCM0475  CL81 HEK-293T C524(0.77); C531(0.77)  LDD1073  [7]
 LDCM0476  CL82 HEK-293T C524(0.92); C531(0.92)  LDD1074  [7]
 LDCM0477  CL83 HEK-293T C524(1.12); C531(1.12)  LDD1075  [7]
 LDCM0478  CL84 HEK-293T C524(0.80); C531(0.80)  LDD1076  [7]
 LDCM0479  CL85 HEK-293T C524(0.77); C531(0.77)  LDD1077  [7]
 LDCM0480  CL86 HEK-293T C524(0.60); C531(0.60)  LDD1078  [7]
 LDCM0481  CL87 HEK-293T C524(0.97); C531(0.97)  LDD1079  [7]
 LDCM0482  CL88 HEK-293T C524(1.08); C531(1.08)  LDD1080  [7]
 LDCM0483  CL89 HEK-293T C524(1.04); C531(1.04)  LDD1081  [7]
 LDCM0484  CL9 HEK-293T C252(0.91); C234(0.76); C819(1.11)  LDD1687  [16]
 LDCM0485  CL90 HEK-293T C524(0.92); C531(0.92)  LDD1083  [7]
 LDCM0486  CL91 HEK-293T C524(1.11); C531(1.11)  LDD1084  [7]
 LDCM0487  CL92 HEK-293T C524(0.86); C531(0.86)  LDD1085  [7]
 LDCM0488  CL93 HEK-293T C524(0.74); C531(0.74)  LDD1086  [7]
 LDCM0489  CL94 HEK-293T C524(0.75); C531(0.75)  LDD1087  [7]
 LDCM0490  CL95 HEK-293T C524(0.86); C531(0.86)  LDD1088  [7]
 LDCM0491  CL96 HEK-293T C524(0.94); C531(0.94)  LDD1089  [7]
 LDCM0492  CL97 HEK-293T C524(0.87); C531(0.87)  LDD1090  [7]
 LDCM0493  CL98 HEK-293T C524(0.77); C531(0.77)  LDD1091  [7]
 LDCM0494  CL99 HEK-293T C524(0.75); C531(0.75)  LDD1092  [7]
 LDCM0495  E2913 HEK-293T C252(1.17); C631(0.81); C234(1.02); C801(0.92)  LDD1698  [16]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [6]
 LDCM0468  Fragment33 HEK-293T C524(0.74); C531(0.74)  LDD1066  [7]
 LDCM0427  Fragment51 HEK-293T C524(0.93); C531(0.93)  LDD1025  [7]
 LDCM0022  KB02 HCT 116 C524(3.74); C531(3.74)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C524(2.06); C531(2.06)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C524(2.87); C531(2.87)  LDD0082  [7]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C848(1.57)  LDD2092  [3]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C848(0.55)  LDD2098  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C848(0.85)  LDD2123  [3]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C848(0.86)  LDD2129  [3]
 LDCM0021  THZ1 HCT 116 C524(1.13); C531(1.13)  LDD2173  [7]
 LDCM0154  YY4 T cell 2.72  LDD0400  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
SH3 domain-binding protein 4 (SH3BP4) . Q9P0V3

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 A Chemical Proteomic Probe for the Mitochondrial Pyruvate Carrier Complex. Angew Chem Int Ed Engl. 2020 Mar 2;59(10):3896-3899. doi: 10.1002/anie.201914391. Epub 2020 Feb 11.
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
14 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
15 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
16 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402