Details of the Target

General Information of Target

Target ID LDTP04321
Target Name Transcription initiation factor TFIID subunit 6 (TAF6)
Gene Name TAF6
Gene ID 6878
Synonyms
TAF2E; TAFII70; Transcription initiation factor TFIID subunit 6; RNA polymerase II TBP-associated factor subunit E; Transcription initiation factor TFIID 70 kDa subunit; TAF(II)70; TAFII-70; TAFII70; Transcription initiation factor TFIID 80 kDa subunit; TAF(II)80; TAFII-80; TAFII80
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAEEKKLKLSNTVLPSESMKVVAESMGIAQIQEETCQLLTDEVSYRIKEIAQDALKFMHM
GKRQKLTTSDIDYALKLKNVEPLYGFHAQEFIPFRFASGGGRELYFYEEKEVDLSDIINT
PLPRVPLDVCLKAHWLSIEGCQPAIPENPPPAPKEQQKAEATEPLKSAKPGQEEDGPLKG
KGQGATTADGKGKEKKAPPLLEGAPLRLKPRSIHELSVEQQLYYKEITEACVGSCEAKRA
EALQSIATDPGLYQMLPRFSTFISEGVRVNVVQNNLALLIYLMRMVKALMDNPTLYLEKY
VHELIPAVMTCIVSRQLCLRPDVDNHWALRDFAARLVAQICKHFSTTTNNIQSRITKTFT
KSWVDEKTPWTTRYGSIAGLAELGHDVIKTLILPRLQQEGERIRSVLDGPVLSNIDRIGA
DHVQSLLLKHCAPVLAKLRPPPDNQDAYRAEFGSLGPLLCSQVVKARAQAALQAQQVNRT
TLTITQPRPTLTLSQAPQPGPRTPGLLKVPGSIALPVQTLVSARAAAPPQPSPPPTKFIV
MSSSSSAPSTQQVLSLSTSAPGSGSTTTSPVTTTVPSVQPIVKLVSTATTAPPSTAPSGP
GSVQKYIVVSLPPTGEGKGGPTSHPSPVPPPASSPSPLSGSALCGGKQEAGDSPPPAPGT
PKANGSQPNSGSPQPAP
Target Bioclass
Other
Family
TAF6 family
Subcellular location
Nucleus
Function
The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C. TAF6 homodimer connects TFIID modules, forming a rigid core.; [Isoform 4]: Transcriptional regulator which acts primarily as a positive regulator of transcription. Recruited to the promoters of a number of genes including GADD45A and CDKN1A/p21, leading to transcriptional up-regulation and subsequent induction of apoptosis. Also up-regulates expression of other genes including GCNA/ACRC, HES1 and IFFO1. In contrast, down-regulates transcription of MDM2. Acts as a transcriptional coactivator to enhance transcription of TP53/p53-responsive genes such as DUSP1. Can also activate transcription and apoptosis independently of TP53. Drives apoptosis via the intrinsic apoptotic pathway by up-regulating apoptosis effectors such as BCL2L11/BIM and PMAIP1/NOXA.
Uniprot ID
P49848
Ensemble ID
ENST00000344095.8
HGNC ID
HGNC:11540

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A549 SNV: p.A663S .
AGS SNV: p.K78T DBIA    Probe Info 
ETK1 SNV: p.K5R .
JURKAT SNV: p.R124W; p.R330Q .
MCC13 SNV: p.S25F DBIA    Probe Info 
MFE319 SNV: p.R467W DBIA    Probe Info 
RL952 SNV: p.R330Ter DBIA    Probe Info 
SNGM SNV: p.T614A DBIA    Probe Info 
SSP25 SNV: p.K5R .
SUIT2 SNV: p.E265G .
SUPT1 SNV: p.R124P DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
BTD
 Probe Info  		C431(2.41)  LDD1700  [2]
AHL-Pu-1
 Probe Info  		C231(2.10)  LDD0173  [3]
EA-probe
 Probe Info  		N.A.  LDD0440  [4]
DBIA
 Probe Info  		C235(41.76)  LDD0209  [5]
ATP probe
 Probe Info  		N.A.  LDD0199  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C460(0.00); C141(0.00); C431(0.00); C130(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		C141(0.00); C431(0.00); C130(0.00)  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		C141(0.00); C431(0.00); C318(0.00); C130(0.00)  LDD0037  [7]
NAIA_5
 Probe Info  		C460(0.00); C644(0.00); C130(0.00)  LDD2224  [8]
WYneO
 Probe Info  		N.A.  LDD0022  [9]
ENE
 Probe Info  		N.A.  LDD0006  [9]
IPM
 Probe Info  		N.A.  LDD0147  [10]
TFBX
 Probe Info  		C341(0.00); C460(0.00); C431(0.00)  LDD0148  [10]
VSF
 Probe Info  		C644(0.00); C130(0.00); C235(0.00)  LDD0007  [9]
Phosphinate-6
 Probe Info  		C141(0.00); C460(0.00); C235(0.00)  LDD0018  [11]
Acrolein
 Probe Info  		N.A.  LDD0217  [12]
W1
 Probe Info  		N.A.  LDD0236  [13]
AOyne
 Probe Info  		14.30  LDD0443  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C431(0.90)  LDD2117  [2]
 LDCM0026  4SU-RNA+native RNA HEK-293T C231(2.10)  LDD0173  [3]
 LDCM0561  Abegg_cp(-)-10 HeLa C130(2.07)  LDD0312  [10]
 LDCM0214  AC1 HEK-293T C431(0.85); C644(0.83); C318(1.08); C341(0.94)  LDD1507  [15]
 LDCM0215  AC10 HEK-293T C431(0.90); C318(1.01); C341(1.14); C130(0.92)  LDD1508  [15]
 LDCM0226  AC11 HEK-293T C431(1.00); C318(1.01); C341(1.03); C130(0.96)  LDD1509  [15]
 LDCM0237  AC12 HEK-293T C431(0.98); C644(1.09); C341(1.08); C130(0.87)  LDD1510  [15]
 LDCM0259  AC14 HEK-293T C431(0.98); C644(1.01); C318(1.08); C341(1.01)  LDD1512  [15]
 LDCM0270  AC15 HEK-293T C431(1.02); C644(1.01); C318(1.07); C341(1.09)  LDD1513  [15]
 LDCM0276  AC17 HEK-293T C431(0.90); C644(0.94); C318(1.01); C341(0.90)  LDD1515  [15]
 LDCM0277  AC18 HEK-293T C431(0.93); C318(0.95); C341(0.95); C130(1.05)  LDD1516  [15]
 LDCM0278  AC19 HEK-293T C431(0.88); C318(1.50); C341(0.86); C130(1.11)  LDD1517  [15]
 LDCM0279  AC2 HEK-293T C431(1.05); C318(0.96); C341(1.16); C130(0.96)  LDD1518  [15]
 LDCM0280  AC20 HEK-293T C431(0.99); C644(0.91); C341(0.98); C130(0.93)  LDD1519  [15]
 LDCM0281  AC21 HEK-293T C431(0.98); C644(0.99); C318(1.08); C341(1.03)  LDD1520  [15]
 LDCM0282  AC22 HEK-293T C431(0.95); C644(1.03); C318(1.04); C341(1.01)  LDD1521  [15]
 LDCM0283  AC23 HEK-293T C431(0.99); C644(1.14); C318(1.00); C341(1.02)  LDD1522  [15]
 LDCM0284  AC24 HEK-293T C431(0.99); C644(1.10); C318(1.06); C341(1.02)  LDD1523  [15]
 LDCM0285  AC25 HEK-293T C431(0.98); C644(0.88); C318(1.08); C341(0.91)  LDD1524  [15]
 LDCM0286  AC26 HEK-293T C431(1.03); C318(1.00); C341(1.05); C130(1.07)  LDD1525  [15]
 LDCM0287  AC27 HEK-293T C431(0.97); C318(1.01); C341(0.93); C130(0.93)  LDD1526  [15]
 LDCM0288  AC28 HEK-293T C431(0.93); C644(1.08); C341(1.01); C130(0.94)  LDD1527  [15]
 LDCM0289  AC29 HEK-293T C431(0.95); C644(1.02); C318(1.01); C341(0.98)  LDD1528  [15]
 LDCM0290  AC3 HEK-293T C431(0.97); C318(1.03); C341(1.00); C130(0.91)  LDD1529  [15]
 LDCM0291  AC30 HEK-293T C431(0.92); C644(1.00); C318(0.95); C341(0.95)  LDD1530  [15]
 LDCM0292  AC31 HEK-293T C431(0.97); C644(1.01); C318(0.95); C341(1.01)  LDD1531  [15]
 LDCM0293  AC32 HEK-293T C431(0.95); C644(1.09); C318(1.07); C341(1.01)  LDD1532  [15]
 LDCM0294  AC33 HEK-293T C431(0.83); C644(0.83); C318(1.04); C341(0.96)  LDD1533  [15]
 LDCM0295  AC34 HEK-293T C431(0.91); C318(1.01); C341(1.13); C130(1.02)  LDD1534  [15]
 LDCM0296  AC35 HEK-293T C431(0.90); C318(1.07); C341(1.02); C130(0.92)  LDD1535  [15]
 LDCM0297  AC36 HEK-293T C431(0.94); C644(1.07); C341(1.07); C130(0.84)  LDD1536  [15]
 LDCM0298  AC37 HEK-293T C431(1.05); C644(1.04); C318(0.98); C341(1.06)  LDD1537  [15]
 LDCM0299  AC38 HEK-293T C431(1.00); C644(1.05); C318(0.94); C341(1.01)  LDD1538  [15]
 LDCM0300  AC39 HEK-293T C431(1.03); C644(1.36); C318(0.94); C341(1.09)  LDD1539  [15]
 LDCM0301  AC4 HEK-293T C431(0.93); C644(0.97); C341(1.05); C130(0.83)  LDD1540  [15]
 LDCM0302  AC40 HEK-293T C431(0.93); C644(1.18); C318(1.15); C341(1.04)  LDD1541  [15]
 LDCM0303  AC41 HEK-293T C431(0.85); C644(0.83); C318(1.05); C341(1.01)  LDD1542  [15]
 LDCM0304  AC42 HEK-293T C431(0.90); C318(1.06); C341(1.08); C130(0.86)  LDD1543  [15]
 LDCM0305  AC43 HEK-293T C431(0.92); C318(1.01); C341(1.03); C130(0.92)  LDD1544  [15]
 LDCM0306  AC44 HEK-293T C431(0.91); C644(1.03); C341(1.12); C130(0.83)  LDD1545  [15]
 LDCM0307  AC45 HEK-293T C431(0.97); C644(1.09); C318(1.01); C341(1.07)  LDD1546  [15]
 LDCM0308  AC46 HEK-293T C431(0.95); C644(1.01); C318(1.02); C341(0.98)  LDD1547  [15]
 LDCM0309  AC47 HEK-293T C431(0.94); C644(0.99); C318(0.94); C341(1.22)  LDD1548  [15]
 LDCM0310  AC48 HEK-293T C431(1.02); C644(1.14); C318(1.15); C341(1.09)  LDD1549  [15]
 LDCM0311  AC49 HEK-293T C431(0.87); C644(0.85); C318(1.03); C341(0.90)  LDD1550  [15]
 LDCM0312  AC5 HEK-293T C431(1.06); C644(1.09); C318(1.03); C341(1.05)  LDD1551  [15]
 LDCM0313  AC50 HEK-293T C431(1.05); C318(0.95); C341(1.01); C130(0.94)  LDD1552  [15]
 LDCM0314  AC51 HEK-293T C431(0.95); C318(0.93); C341(1.01); C130(0.98)  LDD1553  [15]
 LDCM0315  AC52 HEK-293T C431(0.96); C644(1.06); C341(1.09); C130(0.91)  LDD1554  [15]
 LDCM0316  AC53 HEK-293T C431(0.95); C644(1.01); C318(0.97); C341(1.09)  LDD1555  [15]
 LDCM0317  AC54 HEK-293T C431(1.02); C644(1.05); C318(1.02); C341(0.99)  LDD1556  [15]
 LDCM0318  AC55 HEK-293T C431(0.95); C644(1.04); C318(1.00); C341(1.14)  LDD1557  [15]
 LDCM0319  AC56 HEK-293T C431(0.91); C644(1.07); C318(1.09); C341(0.99)  LDD1558  [15]
 LDCM0320  AC57 HEK-293T C431(0.85); C644(0.82); C318(1.13); C341(0.99)  LDD1559  [15]
 LDCM0321  AC58 HEK-293T C431(0.96); C318(0.96); C341(1.02); C130(1.03)  LDD1560  [15]
 LDCM0322  AC59 HEK-293T C431(0.97); C318(0.99); C341(1.07); C130(0.94)  LDD1561  [15]
 LDCM0323  AC6 HEK-293T C431(0.96); C644(0.99); C318(1.07); C341(0.97)  LDD1562  [15]
 LDCM0324  AC60 HEK-293T C431(0.95); C644(0.95); C341(1.06); C130(0.93)  LDD1563  [15]
 LDCM0325  AC61 HEK-293T C431(0.89); C644(0.96); C318(1.07); C341(1.03)  LDD1564  [15]
 LDCM0326  AC62 HEK-293T C431(0.94); C644(0.99); C318(1.00); C341(1.03)  LDD1565  [15]
 LDCM0327  AC63 HEK-293T C431(0.97); C644(0.93); C318(1.09); C341(1.09)  LDD1566  [15]
 LDCM0328  AC64 HEK-293T C431(0.96); C644(1.03); C318(1.03); C341(1.00)  LDD1567  [15]
 LDCM0334  AC7 HEK-293T C431(1.09); C644(1.12); C318(1.04); C341(1.11)  LDD1568  [15]
 LDCM0345  AC8 HEK-293T C431(0.95); C644(1.13); C318(1.12); C341(1.05)  LDD1569  [15]
 LDCM0248  AKOS034007472 HEK-293T C431(1.00); C644(0.98); C318(0.97); C341(1.06)  LDD1511  [15]
 LDCM0356  AKOS034007680 HEK-293T C431(0.87); C644(0.96); C318(1.03); C341(1.02)  LDD1570  [15]
 LDCM0275  AKOS034007705 HEK-293T C431(0.95); C644(1.11); C318(1.01); C341(1.06)  LDD1514  [15]
 LDCM0156  Aniline NCI-H1299 11.46  LDD0403  [1]
 LDCM0632  CL-Sc Hep-G2 C130(1.95); C460(1.24)  LDD2227  [8]
 LDCM0367  CL1 HEK-293T C431(0.98); C644(0.90); C318(1.34); C341(1.02)  LDD1571  [15]
 LDCM0368  CL10 HEK-293T C431(0.82); C644(0.91); C318(2.67); C341(1.40)  LDD1572  [15]
 LDCM0369  CL100 HEK-293T C431(0.96); C318(0.94); C341(1.16); C130(0.84)  LDD1573  [15]
 LDCM0370  CL101 HEK-293T C431(1.00); C644(0.95); C318(1.05); C341(1.06)  LDD1574  [15]
 LDCM0371  CL102 HEK-293T C431(0.89); C341(1.10); C130(0.90); C460(1.01)  LDD1575  [15]
 LDCM0372  CL103 HEK-293T C431(0.97); C644(1.06); C318(1.04); C341(1.08)  LDD1576  [15]
 LDCM0373  CL104 HEK-293T C431(1.03); C318(1.00); C341(1.20); C130(0.90)  LDD1577  [15]
 LDCM0374  CL105 HEK-293T C431(0.97); C644(1.01); C318(1.05); C341(1.02)  LDD1578  [15]
 LDCM0375  CL106 HEK-293T C431(1.06); C341(0.98); C130(0.96); C460(1.00)  LDD1579  [15]
 LDCM0376  CL107 HEK-293T C431(1.01); C644(0.89); C318(0.95); C341(0.97)  LDD1580  [15]
 LDCM0377  CL108 HEK-293T C431(1.03); C318(0.89); C341(1.02); C130(0.93)  LDD1581  [15]
 LDCM0378  CL109 HEK-293T C431(0.97); C644(1.02); C318(1.04); C341(1.02)  LDD1582  [15]
 LDCM0379  CL11 HEK-293T C431(0.90); C644(1.09); C318(1.11); C341(1.17)  LDD1583  [15]
 LDCM0380  CL110 HEK-293T C431(0.93); C341(1.02); C130(0.91); C460(1.06)  LDD1584  [15]
 LDCM0381  CL111 HEK-293T C431(0.96); C644(1.02); C318(0.98); C341(1.06)  LDD1585  [15]
 LDCM0382  CL112 HEK-293T C431(0.89); C318(0.85); C341(1.02); C130(1.00)  LDD1586  [15]
 LDCM0383  CL113 HEK-293T C431(0.93); C644(1.02); C318(1.03); C341(1.09)  LDD1587  [15]
 LDCM0384  CL114 HEK-293T C431(0.93); C341(1.06); C130(0.85); C460(1.10)  LDD1588  [15]
 LDCM0385  CL115 HEK-293T C431(1.00); C644(1.12); C318(0.99); C341(1.01)  LDD1589  [15]
 LDCM0386  CL116 HEK-293T C431(1.01); C318(0.93); C341(1.12); C130(0.95)  LDD1590  [15]
 LDCM0387  CL117 HEK-293T C431(0.93); C644(1.02); C318(0.99); C341(1.05)  LDD1591  [15]
 LDCM0388  CL118 HEK-293T C431(1.06); C341(0.98); C130(0.93); C460(0.88)  LDD1592  [15]
 LDCM0389  CL119 HEK-293T C431(1.01); C644(0.99); C318(0.95); C341(1.13)  LDD1593  [15]
 LDCM0390  CL12 HEK-293T C431(0.90); C644(1.15); C318(1.04); C341(0.98)  LDD1594  [15]
 LDCM0391  CL120 HEK-293T C431(0.97); C318(0.89); C341(1.19); C130(0.95)  LDD1595  [15]
 LDCM0392  CL121 HEK-293T C431(1.00); C644(1.03); C318(1.01); C341(1.02)  LDD1596  [15]
 LDCM0393  CL122 HEK-293T C431(1.02); C341(1.03); C130(0.92); C460(1.01)  LDD1597  [15]
 LDCM0394  CL123 HEK-293T C431(0.99); C644(0.83); C318(1.45); C341(1.64)  LDD1598  [15]
 LDCM0395  CL124 HEK-293T C431(0.97); C318(0.99); C341(1.14); C130(0.96)  LDD1599  [15]
 LDCM0396  CL125 HEK-293T C431(0.91); C644(0.78); C318(1.07); C341(1.07)  LDD1600  [15]
 LDCM0397  CL126 HEK-293T C431(0.95); C341(1.05); C130(0.90); C460(0.98)  LDD1601  [15]
 LDCM0398  CL127 HEK-293T C431(0.98); C644(0.88); C318(1.05); C341(1.04)  LDD1602  [15]
 LDCM0399  CL128 HEK-293T C431(0.93); C318(0.92); C341(1.09); C130(0.87)  LDD1603  [15]
 LDCM0400  CL13 HEK-293T C431(0.96); C644(0.94); C318(1.16); C341(0.95)  LDD1604  [15]
 LDCM0401  CL14 HEK-293T C431(1.00); C341(1.05); C130(0.83); C460(0.93)  LDD1605  [15]
 LDCM0402  CL15 HEK-293T C431(0.91); C644(0.99); C318(1.29); C341(1.26)  LDD1606  [15]
 LDCM0403  CL16 HEK-293T C431(1.02); C318(0.97); C341(1.16); C130(0.91)  LDD1607  [15]
 LDCM0404  CL17 HEK-293T C431(0.79); C644(0.76); C318(1.40); C341(1.18)  LDD1608  [15]
 LDCM0405  CL18 HEK-293T C431(1.01); C318(0.98); C341(1.09); C130(0.90)  LDD1609  [15]
 LDCM0406  CL19 HEK-293T C431(0.91); C318(1.00); C341(0.99); C130(0.90)  LDD1610  [15]
 LDCM0407  CL2 HEK-293T C431(0.99); C341(1.09); C130(0.88); C460(0.99)  LDD1611  [15]
 LDCM0408  CL20 HEK-293T C431(0.99); C644(0.90); C341(1.13); C130(0.87)  LDD1612  [15]
 LDCM0409  CL21 HEK-293T C431(0.84); C644(0.95); C318(1.20); C341(1.18)  LDD1613  [15]
 LDCM0410  CL22 HEK-293T C431(0.93); C644(1.03); C318(1.06); C341(1.06)  LDD1614  [15]
 LDCM0411  CL23 HEK-293T C431(0.92); C644(1.32); C318(0.93); C341(1.18)  LDD1615  [15]
 LDCM0412  CL24 HEK-293T C431(0.93); C644(1.13); C318(0.97); C341(1.03)  LDD1616  [15]
 LDCM0413  CL25 HEK-293T C431(0.96); C644(0.82); C318(1.56); C341(1.09)  LDD1617  [15]
 LDCM0414  CL26 HEK-293T C431(1.12); C341(1.08); C130(0.94); C460(1.01)  LDD1618  [15]
 LDCM0415  CL27 HEK-293T C431(1.01); C644(0.91); C318(1.01); C341(1.07)  LDD1619  [15]
 LDCM0416  CL28 HEK-293T C431(1.04); C318(0.93); C341(1.15); C130(0.91)  LDD1620  [15]
 LDCM0417  CL29 HEK-293T C431(1.04); C644(0.81); C318(1.05); C341(0.95)  LDD1621  [15]
 LDCM0418  CL3 HEK-293T C431(1.03); C644(0.92); C318(1.01); C341(1.20)  LDD1622  [15]
 LDCM0419  CL30 HEK-293T C431(1.06); C318(0.95); C341(1.10); C130(1.00)  LDD1623  [15]
 LDCM0420  CL31 HEK-293T C431(0.93); C318(1.02); C341(1.00); C130(0.95)  LDD1624  [15]
 LDCM0421  CL32 HEK-293T C431(0.97); C644(1.02); C341(1.03); C130(0.91)  LDD1625  [15]
 LDCM0422  CL33 HEK-293T C431(0.93); C644(0.89); C318(2.79); C341(1.26)  LDD1626  [15]
 LDCM0423  CL34 HEK-293T C431(1.06); C644(0.99); C318(1.07); C341(1.19)  LDD1627  [15]
 LDCM0424  CL35 HEK-293T C431(1.01); C644(1.04); C318(0.89); C341(1.17)  LDD1628  [15]
 LDCM0425  CL36 HEK-293T C431(0.96); C644(1.15); C318(1.02); C341(1.02)  LDD1629  [15]
 LDCM0426  CL37 HEK-293T C431(0.96); C644(0.91); C318(1.14); C341(1.06)  LDD1630  [15]
 LDCM0428  CL39 HEK-293T C431(0.99); C644(0.98); C318(1.06); C341(1.12)  LDD1632  [15]
 LDCM0429  CL4 HEK-293T C431(0.98); C318(0.97); C341(1.21); C130(0.89)  LDD1633  [15]
 LDCM0430  CL40 HEK-293T C431(1.08); C318(1.00); C341(1.11); C130(0.87)  LDD1634  [15]
 LDCM0431  CL41 HEK-293T C431(0.89); C644(0.97); C318(1.05); C341(1.01)  LDD1635  [15]
 LDCM0432  CL42 HEK-293T C431(1.07); C318(0.98); C341(1.11); C130(0.90)  LDD1636  [15]
 LDCM0433  CL43 HEK-293T C431(1.13); C318(0.93); C341(1.05); C130(1.02)  LDD1637  [15]
 LDCM0434  CL44 HEK-293T C431(0.94); C644(0.84); C341(1.07); C130(0.89)  LDD1638  [15]
 LDCM0435  CL45 HEK-293T C431(0.82); C644(1.01); C318(1.20); C341(1.02)  LDD1639  [15]
 LDCM0436  CL46 HEK-293T C431(0.99); C644(1.00); C318(0.98); C341(1.07)  LDD1640  [15]
 LDCM0437  CL47 HEK-293T C431(1.00); C644(0.94); C318(1.00); C341(1.15)  LDD1641  [15]
 LDCM0438  CL48 HEK-293T C431(0.92); C644(1.08); C318(1.10); C341(1.07)  LDD1642  [15]
 LDCM0439  CL49 HEK-293T C431(0.97); C644(0.88); C318(1.07); C341(1.07)  LDD1643  [15]
 LDCM0440  CL5 HEK-293T C431(0.91); C644(0.85); C318(1.06); C341(1.05)  LDD1644  [15]
 LDCM0441  CL50 HEK-293T C431(1.02); C341(1.17); C130(0.83); C460(0.97)  LDD1645  [15]
 LDCM0443  CL52 HEK-293T C431(0.98); C318(0.94); C341(1.26); C130(0.88)  LDD1646  [15]
 LDCM0444  CL53 HEK-293T C431(0.79); C644(0.83); C318(1.30); C341(1.21)  LDD1647  [15]
 LDCM0445  CL54 HEK-293T C431(0.89); C318(2.20); C341(2.49); C130(0.87)  LDD1648  [15]
 LDCM0446  CL55 HEK-293T C431(1.02); C318(1.01); C341(1.10); C130(0.89)  LDD1649  [15]
 LDCM0447  CL56 HEK-293T C431(0.90); C644(1.00); C341(1.19); C130(0.84)  LDD1650  [15]
 LDCM0448  CL57 HEK-293T C431(0.81); C644(1.10); C318(1.48); C341(1.16)  LDD1651  [15]
 LDCM0449  CL58 HEK-293T C431(0.93); C644(0.95); C318(1.09); C341(1.06)  LDD1652  [15]
 LDCM0450  CL59 HEK-293T C431(0.99); C644(1.04); C318(0.95); C341(1.29)  LDD1653  [15]
 LDCM0451  CL6 HEK-293T C431(0.90); C318(1.23); C341(1.09); C130(0.94)  LDD1654  [15]
 LDCM0452  CL60 HEK-293T C431(0.92); C644(1.12); C318(1.04); C341(1.05)  LDD1655  [15]
 LDCM0453  CL61 HEK-293T C431(1.08); C644(0.90); C318(1.01); C341(1.10)  LDD1656  [15]
 LDCM0454  CL62 HEK-293T C431(1.13); C341(1.06); C130(0.94); C460(0.87)  LDD1657  [15]
 LDCM0455  CL63 HEK-293T C431(1.04); C644(1.00); C318(0.88); C341(1.08)  LDD1658  [15]
 LDCM0456  CL64 HEK-293T C431(1.00); C318(1.01); C341(1.19); C130(0.85)  LDD1659  [15]
 LDCM0457  CL65 HEK-293T C431(0.98); C644(0.91); C318(1.05); C341(1.01)  LDD1660  [15]
 LDCM0458  CL66 HEK-293T C431(0.98); C318(1.03); C341(1.06); C130(0.89)  LDD1661  [15]
 LDCM0459  CL67 HEK-293T C431(0.92); C318(1.03); C341(1.03); C130(0.87)  LDD1662  [15]
 LDCM0460  CL68 HEK-293T C431(0.96); C644(1.08); C341(1.15); C130(0.87)  LDD1663  [15]
 LDCM0461  CL69 HEK-293T C431(0.92); C644(1.03); C318(1.13); C341(1.14)  LDD1664  [15]
 LDCM0462  CL7 HEK-293T C431(0.95); C318(0.99); C341(1.03); C130(0.98)  LDD1665  [15]
 LDCM0463  CL70 HEK-293T C431(0.99); C644(1.03); C318(1.05); C341(1.11)  LDD1666  [15]
 LDCM0464  CL71 HEK-293T C431(1.01); C644(1.30); C318(0.94); C341(1.26)  LDD1667  [15]
 LDCM0465  CL72 HEK-293T C431(0.90); C644(1.12); C318(0.92); C341(1.14)  LDD1668  [15]
 LDCM0466  CL73 HEK-293T C431(0.95); C644(0.82); C318(0.99); C341(1.06)  LDD1669  [15]
 LDCM0467  CL74 HEK-293T C431(1.10); C341(1.06); C130(0.94); C460(0.89)  LDD1670  [15]
 LDCM0469  CL76 HEK-293T C431(1.02); C318(0.97); C341(1.23); C130(0.93)  LDD1672  [15]
 LDCM0470  CL77 HEK-293T C431(0.85); C644(0.71); C318(1.06); C341(1.05)  LDD1673  [15]
 LDCM0471  CL78 HEK-293T C431(0.99); C318(0.92); C341(1.08); C130(0.93)  LDD1674  [15]
 LDCM0472  CL79 HEK-293T C431(0.96); C318(1.04); C341(1.09); C130(0.82)  LDD1675  [15]
 LDCM0473  CL8 HEK-293T C431(0.88); C644(0.83); C341(6.59); C130(0.80)  LDD1676  [15]
 LDCM0474  CL80 HEK-293T C431(0.94); C644(1.07); C341(1.11); C130(0.89)  LDD1677  [15]
 LDCM0475  CL81 HEK-293T C431(0.90); C644(0.98); C318(0.96); C341(1.11)  LDD1678  [15]
 LDCM0476  CL82 HEK-293T C431(0.96); C644(1.03); C318(0.93); C341(1.03)  LDD1679  [15]
 LDCM0477  CL83 HEK-293T C431(0.93); C644(1.08); C318(1.02); C341(1.16)  LDD1680  [15]
 LDCM0478  CL84 HEK-293T C431(0.91); C644(0.99); C318(1.18); C341(1.12)  LDD1681  [15]
 LDCM0479  CL85 HEK-293T C431(0.96); C644(0.75); C318(1.13); C341(1.14)  LDD1682  [15]
 LDCM0480  CL86 HEK-293T C431(0.97); C341(1.13); C130(0.84); C460(0.98)  LDD1683  [15]
 LDCM0481  CL87 HEK-293T C431(0.95); C644(0.74); C318(1.02); C341(1.07)  LDD1684  [15]
 LDCM0482  CL88 HEK-293T C431(1.02); C318(1.01); C341(1.30); C130(0.88)  LDD1685  [15]
 LDCM0483  CL89 HEK-293T C431(0.87); C644(0.81); C318(1.06); C341(1.00)  LDD1686  [15]
 LDCM0484  CL9 HEK-293T C431(0.91); C644(0.97); C318(1.19); C341(1.12)  LDD1687  [15]
 LDCM0485  CL90 HEK-293T C431(0.82); C318(3.77); C341(1.96); C130(0.89)  LDD1688  [15]
 LDCM0486  CL91 HEK-293T C431(1.01); C318(0.97); C341(1.14); C130(0.94)  LDD1689  [15]
 LDCM0487  CL92 HEK-293T C431(0.93); C644(0.91); C341(1.29); C130(0.83)  LDD1690  [15]
 LDCM0488  CL93 HEK-293T C431(0.84); C644(0.88); C318(1.26); C341(1.15)  LDD1691  [15]
 LDCM0489  CL94 HEK-293T C431(0.88); C644(1.07); C318(1.02); C341(1.07)  LDD1692  [15]
 LDCM0490  CL95 HEK-293T C431(0.85); C644(0.86); C318(2.34); C341(1.61)  LDD1693  [15]
 LDCM0491  CL96 HEK-293T C431(0.90); C644(0.86); C318(1.18); C341(1.05)  LDD1694  [15]
 LDCM0492  CL97 HEK-293T C431(0.94); C644(0.97); C318(1.25); C341(1.10)  LDD1695  [15]
 LDCM0493  CL98 HEK-293T C431(0.96); C341(1.09); C130(0.96); C460(1.00)  LDD1696  [15]
 LDCM0494  CL99 HEK-293T C431(1.07); C644(0.97); C318(0.96); C341(1.10)  LDD1697  [15]
 LDCM0495  E2913 HEK-293T C431(1.00); C644(0.93); C318(0.92); C341(1.15)  LDD1698  [15]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [4]
 LDCM0625  F8 Ramos C341(0.45); C460(0.84)  LDD2187  [16]
 LDCM0573  Fragment11 Ramos C341(0.33); C460(0.34); C141(1.08)  LDD2190  [16]
 LDCM0575  Fragment13 Ramos C341(1.12); C460(1.10)  LDD2192  [16]
 LDCM0576  Fragment14 Ramos C141(0.86)  LDD2193  [16]
 LDCM0580  Fragment21 Ramos C341(0.79); C460(0.75)  LDD2195  [16]
 LDCM0582  Fragment23 Ramos C460(1.01)  LDD2196  [16]
 LDCM0578  Fragment27 Ramos C341(0.77); C460(0.58)  LDD2197  [16]
 LDCM0586  Fragment28 Ramos C341(0.55); C460(0.47); C141(0.74)  LDD2198  [16]
 LDCM0588  Fragment30 Ramos C341(1.08); C460(0.81)  LDD2199  [16]
 LDCM0589  Fragment31 Ramos C341(1.04); C460(4.98)  LDD2200  [16]
 LDCM0468  Fragment33 HEK-293T C431(1.11); C644(0.94); C318(1.07); C341(1.08)  LDD1671  [15]
 LDCM0596  Fragment38 Ramos C341(1.22); C460(2.09)  LDD2203  [16]
 LDCM0566  Fragment4 Ramos C141(1.38)  LDD2184  [16]
 LDCM0427  Fragment51 HEK-293T C431(1.00); C341(1.07); C130(0.99); C460(0.91)  LDD1631  [15]
 LDCM0614  Fragment56 Ramos C341(1.13); C460(0.77)  LDD2205  [16]
 LDCM0569  Fragment7 Ramos C141(0.94)  LDD2186  [16]
 LDCM0022  KB02 HEK-293T C431(0.96); C644(1.04); C141(0.93); C130(0.87)  LDD1492  [15]
 LDCM0023  KB03 Jurkat C235(41.76)  LDD0209  [5]
 LDCM0024  KB05 MKN-1 C468(4.83)  LDD3331  [17]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C431(0.83)  LDD2093  [2]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C341(0.87)  LDD2107  [2]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C431(0.75)  LDD2109  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C431(0.77)  LDD2125  [2]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C431(1.04)  LDD2129  [2]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C431(2.41)  LDD1700  [2]
 LDCM0628  OTUB2-COV-1 HEK-293T C311(0.85)  LDD2207  [18]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
PIH1 domain-containing protein 2 (PIH1D2) PIH1 family Q8WWB5

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
5 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
17 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
18 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.