Details of the Target

General Information of Target

Target ID LDTP00877
Target Name Protein SCO2 homolog, mitochondrial (SCO2)
Gene Name SCO2
Gene ID 9997
Synonyms
Protein SCO2 homolog, mitochondrial
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MLLLTRSPTAWHRLSQLKPRVLPGTLGGQALHLRSWLLSRQGPAETGGQGQPQGPGLRTR
LLITGLFGAGLGGAWLALRAEKERLQQQKRTEALRQAAVGQGDFHLLDHRGRARCKADFR
GQWVLMYFGFTHCPDICPDELEKLVQVVRQLEAEPGLPPVQPVFITVDPERDDVEAMARY
VQDFHPRLLGLTGSTKQVAQASHSYRVYYNAGPKDEDQDYIVDHSIAIYLLNPDGLFTDY
YGRSRSAEQISDSVRRHMAAFRSVLS
Target Bioclass
Enzyme
Family
SCO1/2 family
Subcellular location
Mitochondrion inner membrane
Function
Copper metallochaperone essential for the synthesis and maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Involved in transporting copper to the Cu(A) site on MT-CO2/COX2. Also acts as a thiol-disulfide oxidoreductase to regulate the redox state of the cysteines in SCO1 during maturation of MT-CO2/COX2.
Uniprot ID
O43819
Ensemble ID
ENST00000252785.3
HGNC ID
HGNC:10604

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
EA-probe
 Probe Info  		N.A.  LDD0440  [2]
Acrolein
 Probe Info  		N.A.  LDD0221  [3]
DBIA
 Probe Info  		C137(0.83); C133(1.10)  LDD1507  [4]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [5]
Crotonaldehyde
 Probe Info  		H185(0.00); H203(0.00)  LDD0219  [3]
AOyne
 Probe Info  		15.00  LDD0443  [6]
TPP-AC
 Probe Info  		N.A.  LDD0427  [7]
PAL-AfBPP Probe
Click To Hide/Show 31 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C022
 Probe Info  		10.78  LDD1728  [8]
C040
 Probe Info  		6.77  LDD1740  [8]
C055
 Probe Info  		13.18  LDD1752  [8]
C056
 Probe Info  		20.53  LDD1753  [8]
C143
 Probe Info  		13.74  LDD1825  [8]
C153
 Probe Info  		15.56  LDD1834  [8]
C161
 Probe Info  		12.55  LDD1841  [8]
C169
 Probe Info  		19.84  LDD1849  [8]
C178
 Probe Info  		18.51  LDD1857  [8]
C187
 Probe Info  		24.25  LDD1865  [8]
C191
 Probe Info  		11.96  LDD1868  [8]
C193
 Probe Info  		5.43  LDD1869  [8]
C201
 Probe Info  		29.65  LDD1877  [8]
C218
 Probe Info  		13.55  LDD1892  [8]
C220
 Probe Info  		19.43  LDD1894  [8]
C228
 Probe Info  		18.25  LDD1901  [8]
C231
 Probe Info  		15.56  LDD1904  [8]
C232
 Probe Info  		41.93  LDD1905  [8]
C235
 Probe Info  		29.86  LDD1908  [8]
C348
 Probe Info  		12.04  LDD2009  [8]
C350
 Probe Info  		22.78  LDD2011  [8]
C362
 Probe Info  		35.26  LDD2023  [8]
C388
 Probe Info  		48.17  LDD2047  [8]
C390
 Probe Info  		30.70  LDD2049  [8]
FFF probe11
 Probe Info  		20.00  LDD0471  [9]
FFF probe13
 Probe Info  		20.00  LDD0475  [9]
FFF probe14
 Probe Info  		20.00  LDD0477  [9]
FFF probe15
 Probe Info  		20.00  LDD0478  [9]
FFF probe2
 Probe Info  		20.00  LDD0463  [9]
FFF probe3
 Probe Info  		20.00  LDD0464  [9]
OEA-DA
 Probe Info  		20.00  LDD0046  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C137(0.83); C133(1.10)  LDD1507  [4]
 LDCM0226  AC11 HEK-293T C137(1.03)  LDD1509  [4]
 LDCM0259  AC14 HEK-293T C137(0.90)  LDD1512  [4]
 LDCM0270  AC15 HEK-293T C137(0.98); C133(1.24)  LDD1513  [4]
 LDCM0276  AC17 HEK-293T C137(0.86); C133(1.05)  LDD1515  [4]
 LDCM0278  AC19 HEK-293T C137(0.69)  LDD1517  [4]
 LDCM0282  AC22 HEK-293T C137(0.71)  LDD1521  [4]
 LDCM0283  AC23 HEK-293T C137(0.69); C133(1.15)  LDD1522  [4]
 LDCM0284  AC24 HEK-293T C137(1.00); C133(0.81)  LDD1523  [4]
 LDCM0285  AC25 HEK-293T C137(1.02); C133(0.97)  LDD1524  [4]
 LDCM0287  AC27 HEK-293T C137(0.98)  LDD1526  [4]
 LDCM0290  AC3 HEK-293T C137(0.98)  LDD1529  [4]
 LDCM0291  AC30 HEK-293T C137(0.69)  LDD1530  [4]
 LDCM0292  AC31 HEK-293T C137(1.36); C133(0.93)  LDD1531  [4]
 LDCM0293  AC32 HEK-293T C137(1.02); C133(1.10)  LDD1532  [4]
 LDCM0294  AC33 HEK-293T C137(0.85); C133(1.10)  LDD1533  [4]
 LDCM0296  AC35 HEK-293T C137(0.90)  LDD1535  [4]
 LDCM0299  AC38 HEK-293T C137(0.74)  LDD1538  [4]
 LDCM0300  AC39 HEK-293T C137(1.03); C133(0.91)  LDD1539  [4]
 LDCM0302  AC40 HEK-293T C137(0.99); C133(0.96)  LDD1541  [4]
 LDCM0303  AC41 HEK-293T C137(0.94); C133(1.11)  LDD1542  [4]
 LDCM0305  AC43 HEK-293T C137(0.99)  LDD1544  [4]
 LDCM0308  AC46 HEK-293T C137(0.71)  LDD1547  [4]
 LDCM0309  AC47 HEK-293T C137(0.96); C133(1.21)  LDD1548  [4]
 LDCM0310  AC48 HEK-293T C137(1.06); C133(1.05)  LDD1549  [4]
 LDCM0311  AC49 HEK-293T C137(1.11); C133(1.20)  LDD1550  [4]
 LDCM0314  AC51 HEK-293T C137(0.98)  LDD1553  [4]
 LDCM0317  AC54 HEK-293T C137(0.94)  LDD1556  [4]
 LDCM0318  AC55 HEK-293T C137(1.66); C133(0.99)  LDD1557  [4]
 LDCM0319  AC56 HEK-293T C137(1.13); C133(1.08)  LDD1558  [4]
 LDCM0320  AC57 HEK-293T C137(0.92); C133(1.50)  LDD1559  [4]
 LDCM0322  AC59 HEK-293T C137(1.05)  LDD1561  [4]
 LDCM0323  AC6 HEK-293T C137(0.70)  LDD1562  [4]
 LDCM0326  AC62 HEK-293T C137(0.85)  LDD1565  [4]
 LDCM0327  AC63 HEK-293T C137(0.82); C133(1.22)  LDD1566  [4]
 LDCM0328  AC64 HEK-293T C137(1.13); C133(1.46)  LDD1567  [4]
 LDCM0334  AC7 HEK-293T C137(0.94); C133(1.52)  LDD1568  [4]
 LDCM0345  AC8 HEK-293T C137(1.07); C133(1.06)  LDD1569  [4]
 LDCM0356  AKOS034007680 HEK-293T C137(0.99); C133(1.26)  LDD1570  [4]
 LDCM0275  AKOS034007705 HEK-293T C137(0.92); C133(1.23)  LDD1514  [4]
 LDCM0156  Aniline NCI-H1299 12.16  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [3]
 LDCM0368  CL10 HEK-293T C137(0.73)  LDD1572  [4]
 LDCM0371  CL102 HEK-293T C137(0.47); C133(0.77)  LDD1575  [4]
 LDCM0372  CL103 HEK-293T C133(0.93)  LDD1576  [4]
 LDCM0375  CL106 HEK-293T C137(0.99); C133(0.98)  LDD1579  [4]
 LDCM0376  CL107 HEK-293T C133(0.85)  LDD1580  [4]
 LDCM0379  CL11 HEK-293T C137(1.15); C133(1.23)  LDD1583  [4]
 LDCM0380  CL110 HEK-293T C137(0.89); C133(1.51)  LDD1584  [4]
 LDCM0381  CL111 HEK-293T C133(1.03)  LDD1585  [4]
 LDCM0384  CL114 HEK-293T C137(0.92); C133(0.71)  LDD1588  [4]
 LDCM0385  CL115 HEK-293T C133(0.66)  LDD1589  [4]
 LDCM0388  CL118 HEK-293T C137(0.84); C133(0.49)  LDD1592  [4]
 LDCM0389  CL119 HEK-293T C133(0.98)  LDD1593  [4]
 LDCM0390  CL12 HEK-293T C137(1.01); C133(1.31)  LDD1594  [4]
 LDCM0393  CL122 HEK-293T C137(1.00); C133(0.78)  LDD1597  [4]
 LDCM0394  CL123 HEK-293T C133(1.14)  LDD1598  [4]
 LDCM0397  CL126 HEK-293T C137(0.84); C133(0.71)  LDD1601  [4]
 LDCM0398  CL127 HEK-293T C133(1.04)  LDD1602  [4]
 LDCM0401  CL14 HEK-293T C137(0.87); C133(0.83)  LDD1605  [4]
 LDCM0402  CL15 HEK-293T C133(0.97)  LDD1606  [4]
 LDCM0404  CL17 HEK-293T C137(0.86); C133(1.24)  LDD1608  [4]
 LDCM0406  CL19 HEK-293T C137(1.04)  LDD1610  [4]
 LDCM0407  CL2 HEK-293T C137(0.93); C133(1.23)  LDD1611  [4]
 LDCM0410  CL22 HEK-293T C137(0.81)  LDD1614  [4]
 LDCM0411  CL23 HEK-293T C137(0.92); C133(1.37)  LDD1615  [4]
 LDCM0412  CL24 HEK-293T C137(1.00); C133(1.13)  LDD1616  [4]
 LDCM0414  CL26 HEK-293T C137(0.88); C133(1.16)  LDD1618  [4]
 LDCM0415  CL27 HEK-293T C133(0.94)  LDD1619  [4]
 LDCM0417  CL29 HEK-293T C137(0.86); C133(0.93)  LDD1621  [4]
 LDCM0418  CL3 HEK-293T C133(1.03)  LDD1622  [4]
 LDCM0420  CL31 HEK-293T C137(0.93)  LDD1624  [4]
 LDCM0423  CL34 HEK-293T C137(0.85)  LDD1627  [4]
 LDCM0424  CL35 HEK-293T C137(0.79); C133(0.86)  LDD1628  [4]
 LDCM0425  CL36 HEK-293T C137(1.03); C133(0.94)  LDD1629  [4]
 LDCM0428  CL39 HEK-293T C133(1.12)  LDD1632  [4]
 LDCM0431  CL41 HEK-293T C137(0.70); C133(0.93)  LDD1635  [4]
 LDCM0433  CL43 HEK-293T C137(0.94)  LDD1637  [4]
 LDCM0436  CL46 HEK-293T C137(0.92)  LDD1640  [4]
 LDCM0437  CL47 HEK-293T C137(0.94); C133(1.18)  LDD1641  [4]
 LDCM0438  CL48 HEK-293T C137(1.02); C133(1.02)  LDD1642  [4]
 LDCM0440  CL5 HEK-293T C137(0.89); C133(1.07)  LDD1644  [4]
 LDCM0441  CL50 HEK-293T C137(1.03); C133(0.65)  LDD1645  [4]
 LDCM0444  CL53 HEK-293T C137(1.02); C133(1.21)  LDD1647  [4]
 LDCM0446  CL55 HEK-293T C137(1.02)  LDD1649  [4]
 LDCM0449  CL58 HEK-293T C137(0.83)  LDD1652  [4]
 LDCM0450  CL59 HEK-293T C137(0.77); C133(1.32)  LDD1653  [4]
 LDCM0452  CL60 HEK-293T C137(1.02); C133(1.33)  LDD1655  [4]
 LDCM0454  CL62 HEK-293T C137(1.02); C133(0.80)  LDD1657  [4]
 LDCM0455  CL63 HEK-293T C133(0.87)  LDD1658  [4]
 LDCM0457  CL65 HEK-293T C137(0.99); C133(1.13)  LDD1660  [4]
 LDCM0459  CL67 HEK-293T C137(0.92)  LDD1662  [4]
 LDCM0462  CL7 HEK-293T C137(0.93)  LDD1665  [4]
 LDCM0463  CL70 HEK-293T C137(1.13)  LDD1666  [4]
 LDCM0464  CL71 HEK-293T C137(0.78); C133(1.00)  LDD1667  [4]
 LDCM0465  CL72 HEK-293T C137(1.01); C133(0.93)  LDD1668  [4]
 LDCM0467  CL74 HEK-293T C137(1.03); C133(0.71)  LDD1670  [4]
 LDCM0470  CL77 HEK-293T C137(0.68); C133(1.13)  LDD1673  [4]
 LDCM0472  CL79 HEK-293T C137(1.03)  LDD1675  [4]
 LDCM0476  CL82 HEK-293T C137(0.87)  LDD1679  [4]
 LDCM0477  CL83 HEK-293T C137(1.11); C133(0.84)  LDD1680  [4]
 LDCM0478  CL84 HEK-293T C137(1.09); C133(0.78)  LDD1681  [4]
 LDCM0480  CL86 HEK-293T C137(1.04); C133(0.70)  LDD1683  [4]
 LDCM0481  CL87 HEK-293T C133(0.98)  LDD1684  [4]
 LDCM0483  CL89 HEK-293T C137(0.69); C133(1.17)  LDD1686  [4]
 LDCM0486  CL91 HEK-293T C137(1.13)  LDD1689  [4]
 LDCM0489  CL94 HEK-293T C137(0.92)  LDD1692  [4]
 LDCM0490  CL95 HEK-293T C137(0.80); C133(0.80)  LDD1693  [4]
 LDCM0491  CL96 HEK-293T C137(1.13); C133(1.09)  LDD1694  [4]
 LDCM0493  CL98 HEK-293T C137(0.93); C133(0.86)  LDD1696  [4]
 LDCM0494  CL99 HEK-293T C133(1.07)  LDD1697  [4]
 LDCM0495  E2913 HEK-293T C133(1.08)  LDD1698  [4]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [2]
 LDCM0468  Fragment33 HEK-293T C133(0.89)  LDD1671  [4]
 LDCM0427  Fragment51 HEK-293T C137(0.98); C133(0.59)  LDD1631  [4]
 LDCM0107  IAA HeLa N.A.  LDD0221  [3]
 LDCM0109  NEM HeLa N.A.  LDD0223  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lipid transferase CIDEB (CIDEB) CIDE family Q9UHD4

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
5 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
9 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
10 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570