Details of the Target

General Information of Target

Target ID LDTP10049
Target Name FAST kinase domain-containing protein 4 (TBRG4)
Gene Name TBRG4
Gene ID 9238
Synonyms
CPR2; FASTKD4; KIAA0948; FAST kinase domain-containing protein 4; Cell cycle progression restoration protein 2; Cell cycle progression protein 2; Protein TBRG4; Transforming growth factor beta regulator 4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MWRGLWTLAAQAARGPRRLCTRRSSGAPAPGSGATIFALSSGQGRCGIAVIRTSGPASGH
ALRILTAPRDLPLARHASLRLLSDPRSGEPLDRALVLWFPGPQSFTGEDCVEFHVHGGPA
VVSGVLQALGSVPGLRPAEAGEFTRRAFANGKLNLTEVEGLADLIHAETEAQRRQALRQL
DGELGHLCRGWAETLTKALAHVEAYIDFGEDDNLEEGVLEQADIEVRALQVALGAHLRDA
RRGQRLRSGVHVVVTGPPNAGKSSLVNLLSRKPVSIVSPEPGTTRDVLETPVDLAGFPVL
LSDTAGLREGVGPVEQEGVRRARERLEQADLILAMLDASDLASPSSCNFLATVVASVGAQ
SPSDSSQRLLLVLNKSDLLSPEGPGPGPDLPPHLLLSCLTGEGLDGLLEALRKELAAVCG
DPSTDPPLLTRARHQHHLQGCLDALGHYKQSKDLALAAEALRVARGHLTRLTGGGGTEEI
LDIIFQDFCVGK
Target Bioclass
Enzyme
Family
FAST kinase family
Subcellular location
Mitochondrion matrix
Function
Plays a role in processing of mitochondrial RNA precursors and in stabilization of a subset of mature mitochondrial RNA species, such as MT-CO1, MT-CO2, MT-CYB, MT-CO3, MT-ND3, MT-ND5 and MT-ATP8/6. May play a role in cell cycle progression.
Uniprot ID
Q969Z0
Ensemble ID
ENST00000258770.8
HGNC ID
HGNC:17443

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.A79T .
LNCaP clone FGC SNV: p.R175C DBIA    Probe Info 
MEWO SNV: p.L5V DBIA    Probe Info 
MOLT4 SNV: p.A333D IA-alkyne    Probe Info 
NB1 SNV: p.M102V DBIA    Probe Info 
NCIH1993 SNV: p.A278V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 29 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.50  LDD0402  [1]
N1
 Probe Info  		100.00  LDD0242  [2]
TH211
 Probe Info  		Y281(5.88)  LDD0257  [3]
TH214
 Probe Info  		Y281(20.00)  LDD0258  [3]
TH216
 Probe Info  		Y281(20.00)  LDD0259  [3]
STPyne
 Probe Info  		K163(5.56); K488(7.34); K576(7.22); K618(1.02)  LDD0277  [4]
ONAyne
 Probe Info  		K576(10.00)  LDD0275  [4]
Probe 1
 Probe Info  		Y67(55.00)  LDD3495  [5]
BTD
 Probe Info  		C246(2.49)  LDD2119  [6]
EA-probe
 Probe Info  		N.A.  LDD0440  [7]
DBIA
 Probe Info  		C246(0.57)  LDD0531  [8]
5E-2FA
 Probe Info  		N.A.  LDD2235  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C370(0.00); C246(0.00); C335(0.00); C191(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [11]
Lodoacetamide azide
 Probe Info  		C246(0.00); C132(0.00); C191(0.00); C335(0.00)  LDD0037  [10]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [12]
TFBX
 Probe Info  		N.A.  LDD0027  [12]
WYneN
 Probe Info  		N.A.  LDD0021  [13]
Compound 10
 Probe Info  		N.A.  LDD2216  [14]
Compound 11
 Probe Info  		N.A.  LDD2213  [14]
IPM
 Probe Info  		C246(0.00); C335(0.00)  LDD0005  [13]
VSF
 Probe Info  		N.A.  LDD0007  [13]
Ox-W18
 Probe Info  		N.A.  LDD2175  [15]
1c-yne
 Probe Info  		N.A.  LDD0228  [16]
Acrolein
 Probe Info  		C335(0.00); H109(0.00)  LDD0217  [17]
W1
 Probe Info  		N.A.  LDD0236  [18]
AOyne
 Probe Info  		15.00  LDD0443  [19]
NAIA_5
 Probe Info  		C370(0.00); C246(0.00); C191(0.00); C335(0.00)  LDD2223  [20]
HHS-465
 Probe Info  		N.A.  LDD2240  [21]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		20.00  LDD0475  [22]
FFF probe14
 Probe Info  		13.27  LDD0477  [22]
STS-2
 Probe Info  		N.A.  LDD0139  [23]
VE-P
 Probe Info  		N.A.  LDD0396  [24]
Alk-rapa
 Probe Info  		41.70  LDD0213  [25]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C246(0.57)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C246(0.78)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C246(0.78)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C246(0.80)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C246(0.80)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C246(0.80)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C246(0.63)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C246(0.83)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C246(0.87)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C246(0.74)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C246(0.73)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C246(0.68)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C246(0.82)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C246(0.73)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C246(0.81)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C246(0.76)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C246(1.02)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C246(0.95)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C246(0.87)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C246(0.71)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C246(0.91)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C246(0.78)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C246(0.79)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C246(0.86)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C246(1.11)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C246(1.22)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C246(0.81)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C246(1.23)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C246(1.27)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C246(1.07)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C246(0.86)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C246(0.82)  LDD0562  [8]
 LDCM0246  AC128 HCT 116 C246(1.18)  LDD0563  [8]
 LDCM0247  AC129 HCT 116 C246(1.32)  LDD0564  [8]
 LDCM0249  AC130 HCT 116 C246(1.47)  LDD0566  [8]
 LDCM0250  AC131 HCT 116 C246(0.83)  LDD0567  [8]
 LDCM0251  AC132 HCT 116 C246(1.15)  LDD0568  [8]
 LDCM0252  AC133 HCT 116 C246(0.90)  LDD0569  [8]
 LDCM0253  AC134 HCT 116 C246(1.00)  LDD0570  [8]
 LDCM0254  AC135 HCT 116 C246(0.52)  LDD0571  [8]
 LDCM0255  AC136 HCT 116 C246(0.96)  LDD0572  [8]
 LDCM0256  AC137 HCT 116 C246(1.36)  LDD0573  [8]
 LDCM0257  AC138 HCT 116 C246(0.86)  LDD0574  [8]
 LDCM0258  AC139 HCT 116 C246(1.28)  LDD0575  [8]
 LDCM0259  AC14 HCT 116 C246(0.96)  LDD0576  [8]
 LDCM0260  AC140 HCT 116 C246(0.89)  LDD0577  [8]
 LDCM0261  AC141 HCT 116 C246(0.85)  LDD0578  [8]
 LDCM0262  AC142 HCT 116 C246(0.80)  LDD0579  [8]
 LDCM0263  AC143 PaTu 8988t C246(0.81)  LDD1142  [8]
 LDCM0264  AC144 PaTu 8988t C246(0.78)  LDD1143  [8]
 LDCM0265  AC145 PaTu 8988t C246(0.96)  LDD1144  [8]
 LDCM0266  AC146 PaTu 8988t C246(0.60)  LDD1145  [8]
 LDCM0267  AC147 PaTu 8988t C246(0.98)  LDD1146  [8]
 LDCM0268  AC148 PaTu 8988t C246(0.62)  LDD1147  [8]
 LDCM0269  AC149 PaTu 8988t C246(0.87)  LDD1148  [8]
 LDCM0270  AC15 HCT 116 C246(0.75)  LDD0587  [8]
 LDCM0271  AC150 PaTu 8988t C246(0.81)  LDD1150  [8]
 LDCM0272  AC151 PaTu 8988t C246(0.79)  LDD1151  [8]
 LDCM0273  AC152 PaTu 8988t C246(0.86)  LDD1152  [8]
 LDCM0274  AC153 PaTu 8988t C246(0.70)  LDD1153  [8]
 LDCM0621  AC154 PaTu 8988t C246(0.76)  LDD2166  [8]
 LDCM0622  AC155 PaTu 8988t C246(0.80)  LDD2167  [8]
 LDCM0623  AC156 PaTu 8988t C246(0.83)  LDD2168  [8]
 LDCM0624  AC157 PaTu 8988t C246(0.86)  LDD2169  [8]
 LDCM0276  AC17 HCT 116 C246(0.89)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C246(0.72)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C246(1.03)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C246(0.65)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C246(1.05)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C246(0.89)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C246(0.98)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C246(0.94)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C246(1.20)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C246(1.05)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C246(1.07)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C246(0.88)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C246(1.13)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C246(0.81)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C246(0.54)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C246(0.91)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C246(1.00)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C246(1.00)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C246(0.84)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C246(0.77)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C246(0.91)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C246(0.98)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C246(1.11)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C246(1.24)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C246(1.24)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C246(0.61)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C246(1.14)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C246(1.13)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C246(1.24)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C246(1.11)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C246(1.37)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C246(1.33)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C246(1.08)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C246(1.30)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C246(1.73)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C246(1.14)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C246(0.60)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C246(1.45)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C246(1.21)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C246(1.29)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C246(1.18)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C246(1.19)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C246(1.49)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C246(1.73)  LDD0636  [8]
 LDCM0320  AC57 HEK-293T C246(0.90)  LDD0918  [8]
 LDCM0321  AC58 HEK-293T C246(0.97)  LDD0919  [8]
 LDCM0322  AC59 HEK-293T C246(0.74)  LDD0920  [8]
 LDCM0323  AC6 HCT 116 C246(0.98)  LDD0640  [8]
 LDCM0324  AC60 HEK-293T C246(0.78)  LDD0922  [8]
 LDCM0325  AC61 HEK-293T C246(0.62)  LDD0923  [8]
 LDCM0326  AC62 HEK-293T C246(0.88)  LDD0924  [8]
 LDCM0327  AC63 HEK-293T C246(0.69)  LDD0925  [8]
 LDCM0328  AC64 HEK-293T C246(0.81)  LDD0926  [8]
 LDCM0329  AC65 HEK-293T C246(0.59)  LDD0927  [8]
 LDCM0330  AC66 HEK-293T C246(0.82)  LDD0928  [8]
 LDCM0331  AC67 HEK-293T C246(0.80)  LDD0929  [8]
 LDCM0332  AC68 HCT 116 C246(1.17)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C246(1.02)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C246(0.89)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C246(0.93)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C246(1.40)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C246(1.01)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C246(0.96)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C246(1.32)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C246(1.18)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C246(1.10)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C246(1.21)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C246(1.09)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C246(1.08)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C246(0.83)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C246(1.01)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C246(0.90)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C246(1.19)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C246(0.75)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C246(0.98)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C246(0.31)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C246(1.06)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C246(0.91)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C246(1.27)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C246(0.88)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C246(0.92)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C246(0.69)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C246(0.60)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C246(0.97)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C246(0.59)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C246(0.83)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C246(0.24)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C246(1.06)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C246(0.75)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C246(0.90)  LDD0683  [8]
 LDCM0248  AKOS034007472 HCT 116 C246(1.01)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C246(0.94)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C246(0.97)  LDD0592  [8]
 LDCM0156  Aniline NCI-H1299 12.76  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C246(1.12)  LDD2171  [8]
 LDCM0108  Chloroacetamide HeLa H109(0.00); H308(0.00)  LDD0222  [17]
 LDCM0632  CL-Sc Hep-G2 C335(0.65); C246(0.41)  LDD2227  [20]
 LDCM0367  CL1 HEK-293T C246(0.76)  LDD0965  [8]
 LDCM0368  CL10 HEK-293T C246(0.16)  LDD0966  [8]
 LDCM0369  CL100 HCT 116 C246(0.55)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C246(0.75)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C246(0.91)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C246(0.72)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C246(0.82)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C246(0.85)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C246(0.97)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C246(0.97)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C246(0.95)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C246(0.72)  LDD0695  [8]
 LDCM0379  CL11 HEK-293T C246(0.19)  LDD0977  [8]
 LDCM0380  CL110 HCT 116 C246(0.77)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C246(0.85)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C246(0.95)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C246(0.79)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C246(0.79)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C246(0.79)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C246(0.91)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C246(1.44)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C246(1.50)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C246(1.08)  LDD0706  [8]
 LDCM0390  CL12 HEK-293T C246(1.25)  LDD0988  [8]
 LDCM0391  CL120 HCT 116 C246(1.32)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C246(1.62)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C246(1.17)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C246(1.22)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C246(1.36)  LDD0712  [8]
 LDCM0396  CL125 HEK-293T C246(0.80)  LDD0994  [8]
 LDCM0397  CL126 HEK-293T C246(0.72)  LDD0995  [8]
 LDCM0398  CL127 HEK-293T C246(0.90)  LDD0996  [8]
 LDCM0399  CL128 HEK-293T C246(1.06)  LDD0997  [8]
 LDCM0400  CL13 HEK-293T C246(0.97)  LDD0998  [8]
 LDCM0401  CL14 HEK-293T C246(0.78)  LDD0999  [8]
 LDCM0402  CL15 HEK-293T C246(0.61)  LDD1000  [8]
 LDCM0403  CL16 PaTu 8988t C246(1.04)  LDD1282  [8]
 LDCM0404  CL17 HCT 116 C246(0.86)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C246(1.12)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C246(1.05)  LDD0723  [8]
 LDCM0407  CL2 HEK-293T C246(1.03)  LDD1005  [8]
 LDCM0408  CL20 HCT 116 C246(0.87)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C246(0.76)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C246(0.66)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C246(0.73)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C246(1.18)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C246(1.02)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C246(0.94)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C246(0.86)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C246(1.14)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C246(0.69)  LDD0734  [8]
 LDCM0418  CL3 HEK-293T C246(0.79)  LDD1016  [8]
 LDCM0419  CL30 HCT 116 C246(1.31)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C246(1.04)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C246(0.93)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C246(0.89)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C246(1.84)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C246(1.29)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C246(1.24)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C246(1.33)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C246(1.16)  LDD0745  [8]
 LDCM0429  CL4 HEK-293T C246(0.74)  LDD1027  [8]
 LDCM0430  CL40 HCT 116 C246(0.90)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C246(1.11)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C246(1.35)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C246(1.41)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C246(1.13)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C246(1.48)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C246(0.75)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C246(0.87)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C246(0.83)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C246(0.79)  LDD0756  [8]
 LDCM0440  CL5 HEK-293T C246(0.96)  LDD1038  [8]
 LDCM0441  CL50 HCT 116 C246(0.86)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C246(0.73)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C246(0.81)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C246(1.18)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C246(0.79)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C246(0.87)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C246(1.00)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C246(1.09)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C246(0.84)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C246(0.99)  LDD0767  [8]
 LDCM0451  CL6 HEK-293T C246(0.90)  LDD1049  [8]
 LDCM0452  CL60 HCT 116 C246(0.67)  LDD0769  [8]
 LDCM0453  CL61 HEK-293T C246(1.00)  LDD1051  [8]
 LDCM0454  CL62 HEK-293T C246(1.05)  LDD1052  [8]
 LDCM0455  CL63 HEK-293T C246(1.20)  LDD1053  [8]
 LDCM0456  CL64 HEK-293T C246(1.16)  LDD1054  [8]
 LDCM0457  CL65 HEK-293T C246(1.17)  LDD1055  [8]
 LDCM0458  CL66 HEK-293T C246(1.13)  LDD1056  [8]
 LDCM0459  CL67 HEK-293T C246(1.14)  LDD1057  [8]
 LDCM0460  CL68 HEK-293T C246(1.21)  LDD1058  [8]
 LDCM0461  CL69 HEK-293T C246(1.01)  LDD1059  [8]
 LDCM0462  CL7 HEK-293T C246(0.51)  LDD1060  [8]
 LDCM0463  CL70 HEK-293T C246(1.04)  LDD1061  [8]
 LDCM0464  CL71 HEK-293T C246(1.33)  LDD1062  [8]
 LDCM0465  CL72 HEK-293T C246(0.94)  LDD1063  [8]
 LDCM0466  CL73 HEK-293T C246(1.00)  LDD1064  [8]
 LDCM0467  CL74 HEK-293T C246(0.40)  LDD1065  [8]
 LDCM0469  CL76 HCT 116 C246(0.90)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C246(0.75)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C246(0.63)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C246(0.73)  LDD0789  [8]
 LDCM0473  CL8 HEK-293T C246(0.18)  LDD1071  [8]
 LDCM0474  CL80 HCT 116 C246(0.70)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C246(0.67)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C246(0.89)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C246(0.76)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C246(0.82)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C246(0.73)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C246(0.60)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C246(0.82)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C246(0.87)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C246(0.98)  LDD0800  [8]
 LDCM0484  CL9 HEK-293T C246(0.71)  LDD1082  [8]
 LDCM0485  CL90 HCT 116 C246(0.61)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C246(0.82)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C246(0.74)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C246(0.78)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C246(0.77)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C246(0.78)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C246(0.71)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C246(0.65)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C246(0.55)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C246(0.53)  LDD0811  [8]
 LDCM0495  E2913 HEK-293T C246(0.90); C335(1.06); C370(0.98); C191(0.91)  LDD1698  [26]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C335(17.87)  LDD1702  [6]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [7]
 LDCM0625  F8 Ramos C246(2.62); C370(1.13); C335(0.88)  LDD2187  [27]
 LDCM0573  Fragment11 Ramos C370(0.64); C335(0.16)  LDD2190  [27]
 LDCM0574  Fragment12 Ramos C335(7.26)  LDD2191  [27]
 LDCM0575  Fragment13 Ramos C246(1.86); C335(1.36)  LDD2192  [27]
 LDCM0576  Fragment14 Ramos C246(4.67); C370(15.65); C335(4.87)  LDD2193  [27]
 LDCM0579  Fragment20 Ramos C335(7.47)  LDD2194  [27]
 LDCM0580  Fragment21 Ramos C246(0.81); C335(1.39)  LDD2195  [27]
 LDCM0582  Fragment23 Ramos C246(0.93); C335(1.55)  LDD2196  [27]
 LDCM0578  Fragment27 Ramos C246(0.65); C335(0.96)  LDD2197  [27]
 LDCM0586  Fragment28 Ramos C246(1.01); C370(1.34); C335(0.76)  LDD2198  [27]
 LDCM0588  Fragment30 Ramos C246(0.76); C335(1.27)  LDD2199  [27]
 LDCM0589  Fragment31 Ramos C246(0.77); C335(2.47)  LDD2200  [27]
 LDCM0590  Fragment32 Ramos C335(20.00)  LDD2201  [27]
 LDCM0468  Fragment33 HEK-293T C246(1.03)  LDD1066  [8]
 LDCM0596  Fragment38 Ramos C246(2.02); C335(2.04)  LDD2203  [27]
 LDCM0566  Fragment4 Ramos C246(1.67); C370(1.89); C335(3.81)  LDD2184  [27]
 LDCM0427  Fragment51 HCT 116 C246(1.38)  LDD0744  [8]
 LDCM0610  Fragment52 Ramos C246(2.03); C335(2.60)  LDD2204  [27]
 LDCM0614  Fragment56 Ramos C246(0.65); C335(1.17)  LDD2205  [27]
 LDCM0569  Fragment7 Ramos C246(1.72); C370(2.08); C335(4.39)  LDD2186  [27]
 LDCM0149  GA MCF-7 C335(2.15)  LDD0379  [28]
 LDCM0015  HNE MDA-MB-231 C335(1.44)  LDD0346  [27]
 LDCM0107  IAA HeLa H308(0.00); H109(0.00); H334(0.00); H233(0.00)  LDD0221  [17]
 LDCM0022  KB02 HEK-293T C246(0.94); C191(1.00); C370(1.02); C335(1.06)  LDD1492  [26]
 LDCM0023  KB03 HEK-293T C246(0.96); C191(1.00); C370(1.07); C335(0.89)  LDD1497  [26]
 LDCM0024  KB05 G361 C370(1.90); C246(3.06)  LDD3311  [29]
 LDCM0109  NEM HeLa H109(0.00); H308(0.00); H252(0.00)  LDD0223  [17]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C246(2.49)  LDD2119  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C246(0.86)  LDD2123  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C246(1.10); C335(0.88)  LDD2125  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C246(1.11)  LDD2137  [6]
 LDCM0627  NUDT7-COV-1 HEK-293T C335(0.36); C191(0.16)  LDD2206  [30]
 LDCM0628  OTUB2-COV-1 HEK-293T C246(0.98); C335(0.73); C191(0.52); C370(0.43)  LDD2207  [30]
 LDCM0090  Rapamycin JHH-7 41.70  LDD0213  [25]
 LDCM0021  THZ1 HCT 116 C246(1.12)  LDD2173  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13) Short-chain dehydrogenases/reductases (SDR) family Q7Z5P4
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Secretory carrier-associated membrane protein 1 (SCAMP1) SCAMP family O15126
Barttin (BSND) . Q8WZ55
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
G-protein coupled receptor-associated sorting protein 2 (GPRASP2) GPRASP family Q96D09
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tumor necrosis factor receptor superfamily member 10D (TNFRSF10D) . Q9UBN6
Other
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2) CALCOCO family Q13137
Cerebellar degeneration-related protein 2-like (CDR2L) CDR2 family Q86X02
Protein FAM114A2 (FAM114A2) FAM114 family Q9NRY5
Protein FAM9B (FAM9B) FAM9 family Q8IZU0
Keratin, type I cytoskeletal 27 (KRT27) Intermediate filament family Q7Z3Y8
Protein MAL2 (MAL2) MAL family Q969L2
Reticulophagy regulator 3 (RETREG3) RETREG family Q86VR2
Vesicle transport protein SFT2A (SFT2D1) SFT2 family Q8WV19
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
Basic salivary proline-rich protein 3 (PRB3) . Q04118
Lck-interacting transmembrane adapter 1 (LIME1) . Q9H400
Type-1 angiotensin II receptor-associated protein (AGTRAP) . Q6RW13

References

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2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
15 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
16 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
18 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
19 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
20 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
21 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
22 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
23 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
24 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
25 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
26 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
27 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
28 Combined Omics Approach Identifies Gambogic Acid and Related Xanthones as Covalent Inhibitors of the Serine Palmitoyltransferase Complex. Cell Chem Biol. 2020 May 21;27(5):586-597.e12. doi: 10.1016/j.chembiol.2020.03.008. Epub 2020 Apr 23.
29 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
30 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.