Details of the Target

General Information of Target

Target ID LDTP11139
Target Name DNA replication complex GINS protein PSF3 (GINS3)
Gene Name GINS3
Gene ID 64785
Synonyms
PSF3; DNA replication complex GINS protein PSF3; GINS complex subunit 3
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MKLVRKNIEKDNAGQVTLVPEEPEDMWHTYNLVQVGDSLRASTIRKVQTESSTGSVGSNR
VRTTLTLCVEAIDFDSQACQLRVKGTNIQENEYVKMGAYHTIELEPNRQFTLAKKQWDSV
VLERIEQACDPAWSADVAAVVMQEGLAHICLVTPSMTLTRAKVEVNIPRKRKGNCSQHDR
ALERFYEQVVQAIQRHIHFDVVKCILVASPGFVREQFCDYLFQQAVKTDNKLLLENRSKF
LQVHASSGHKYSLKEALCDPTVASRLSDTKAAGEVKALDDFYKMLQHEPDRAFYGLKQVE
KANEAMAIDTLLISDELFRHQDVATRSRYVRLVDSVKENAGTVRIFSSLHVSGEQLSQLT
GVAAILRFPVPELSDQEGDSSSEED
Target Bioclass
Other
Family
GINS3/PSF3 family
Subcellular location
Nucleus
Function
Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.
Uniprot ID
Q9BRX5
Ensemble ID
ENST00000318129.6
HGNC ID
HGNC:25851

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
IPC298 SNV: p.E130K DBIA    Probe Info 
JHH7 SNV: p.L43R .
MCC26 SNV: p.G144E DBIA    Probe Info 
MELJUSO SNV: p.P104L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
FBP2
 Probe Info  		2.94  LDD0323  [2]
Probe 1
 Probe Info  		Y157(7.87)  LDD3495  [3]
DBIA
 Probe Info  		C227(1.86)  LDD3319  [4]
EA-probe
 Probe Info  		N.A.  LDD0440  [5]
HHS-465
 Probe Info  		Y157(10.00); Y206(4.55)  LDD2237  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [7]
IPM
 Probe Info  		N.A.  LDD0005  [8]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [9]
1c-yne
 Probe Info  		N.A.  LDD0228  [10]
Acrolein
 Probe Info  		N.A.  LDD0217  [11]
W1
 Probe Info  		N.A.  LDD0236  [12]
AOyne
 Probe Info  		12.00  LDD0443  [13]
NAIA_5
 Probe Info  		N.A.  LDD2223  [14]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C364
 Probe Info  		16.11  LDD2025  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C188(0.99)  LDD1507  [16]
 LDCM0215  AC10 HEK-293T C188(0.91)  LDD1508  [16]
 LDCM0226  AC11 HEK-293T C188(0.93)  LDD1509  [16]
 LDCM0237  AC12 HEK-293T C188(1.02)  LDD1510  [16]
 LDCM0259  AC14 HEK-293T C188(1.00)  LDD1512  [16]
 LDCM0270  AC15 HEK-293T C188(1.05)  LDD1513  [16]
 LDCM0276  AC17 HEK-293T C188(1.08)  LDD1515  [16]
 LDCM0277  AC18 HEK-293T C188(0.97)  LDD1516  [16]
 LDCM0278  AC19 HEK-293T C188(0.93)  LDD1517  [16]
 LDCM0279  AC2 HEK-293T C188(0.87)  LDD1518  [16]
 LDCM0280  AC20 HEK-293T C188(1.12)  LDD1519  [16]
 LDCM0281  AC21 HEK-293T C188(1.01)  LDD1520  [16]
 LDCM0282  AC22 HEK-293T C188(1.11)  LDD1521  [16]
 LDCM0283  AC23 HEK-293T C188(1.09)  LDD1522  [16]
 LDCM0284  AC24 HEK-293T C188(1.09)  LDD1523  [16]
 LDCM0285  AC25 HEK-293T C188(1.06)  LDD1524  [16]
 LDCM0286  AC26 HEK-293T C188(0.93)  LDD1525  [16]
 LDCM0287  AC27 HEK-293T C188(1.04)  LDD1526  [16]
 LDCM0288  AC28 HEK-293T C188(1.00)  LDD1527  [16]
 LDCM0289  AC29 HEK-293T C188(0.97)  LDD1528  [16]
 LDCM0290  AC3 HEK-293T C188(0.95)  LDD1529  [16]
 LDCM0291  AC30 HEK-293T C188(1.05)  LDD1530  [16]
 LDCM0292  AC31 HEK-293T C188(1.00)  LDD1531  [16]
 LDCM0293  AC32 HEK-293T C188(1.06)  LDD1532  [16]
 LDCM0294  AC33 HEK-293T C188(0.98)  LDD1533  [16]
 LDCM0295  AC34 HEK-293T C188(0.96)  LDD1534  [16]
 LDCM0296  AC35 HEK-293T C188(1.03)  LDD1535  [16]
 LDCM0297  AC36 HEK-293T C188(1.00)  LDD1536  [16]
 LDCM0298  AC37 HEK-293T C188(0.93)  LDD1537  [16]
 LDCM0299  AC38 HEK-293T C188(0.97)  LDD1538  [16]
 LDCM0300  AC39 HEK-293T C188(1.03)  LDD1539  [16]
 LDCM0301  AC4 HEK-293T C188(0.97)  LDD1540  [16]
 LDCM0302  AC40 HEK-293T C188(1.00)  LDD1541  [16]
 LDCM0303  AC41 HEK-293T C188(1.03)  LDD1542  [16]
 LDCM0304  AC42 HEK-293T C188(0.92)  LDD1543  [16]
 LDCM0305  AC43 HEK-293T C188(1.04)  LDD1544  [16]
 LDCM0306  AC44 HEK-293T C188(1.04)  LDD1545  [16]
 LDCM0307  AC45 HEK-293T C188(0.95)  LDD1546  [16]
 LDCM0308  AC46 HEK-293T C188(0.98)  LDD1547  [16]
 LDCM0309  AC47 HEK-293T C188(1.00)  LDD1548  [16]
 LDCM0310  AC48 HEK-293T C188(0.99)  LDD1549  [16]
 LDCM0311  AC49 HEK-293T C188(0.99)  LDD1550  [16]
 LDCM0312  AC5 HEK-293T C188(0.99)  LDD1551  [16]
 LDCM0313  AC50 HEK-293T C188(0.88)  LDD1552  [16]
 LDCM0314  AC51 HEK-293T C188(1.03)  LDD1553  [16]
 LDCM0315  AC52 HEK-293T C188(1.05)  LDD1554  [16]
 LDCM0316  AC53 HEK-293T C188(0.98)  LDD1555  [16]
 LDCM0317  AC54 HEK-293T C188(1.03)  LDD1556  [16]
 LDCM0318  AC55 HEK-293T C188(1.02)  LDD1557  [16]
 LDCM0319  AC56 HEK-293T C188(1.06)  LDD1558  [16]
 LDCM0320  AC57 HEK-293T C188(1.05)  LDD1559  [16]
 LDCM0321  AC58 HEK-293T C188(0.91)  LDD1560  [16]
 LDCM0322  AC59 HEK-293T C188(1.03)  LDD1561  [16]
 LDCM0323  AC6 HEK-293T C188(0.97)  LDD1562  [16]
 LDCM0324  AC60 HEK-293T C188(1.00)  LDD1563  [16]
 LDCM0325  AC61 HEK-293T C188(0.97)  LDD1564  [16]
 LDCM0326  AC62 HEK-293T C188(1.09)  LDD1565  [16]
 LDCM0327  AC63 HEK-293T C188(1.01)  LDD1566  [16]
 LDCM0328  AC64 HEK-293T C188(0.99)  LDD1567  [16]
 LDCM0334  AC7 HEK-293T C188(0.93)  LDD1568  [16]
 LDCM0345  AC8 HEK-293T C188(0.97)  LDD1569  [16]
 LDCM0248  AKOS034007472 HEK-293T C188(1.01)  LDD1511  [16]
 LDCM0356  AKOS034007680 HEK-293T C188(0.99)  LDD1570  [16]
 LDCM0275  AKOS034007705 HEK-293T C188(0.94)  LDD1514  [16]
 LDCM0367  CL1 HEK-293T C188(0.89)  LDD1571  [16]
 LDCM0368  CL10 HEK-293T C188(0.91)  LDD1572  [16]
 LDCM0369  CL100 HEK-293T C188(0.96)  LDD1573  [16]
 LDCM0370  CL101 HEK-293T C188(0.95)  LDD1574  [16]
 LDCM0371  CL102 HEK-293T C188(0.96)  LDD1575  [16]
 LDCM0372  CL103 HEK-293T C188(1.04)  LDD1576  [16]
 LDCM0373  CL104 HEK-293T C188(0.98)  LDD1577  [16]
 LDCM0374  CL105 HEK-293T C188(1.08)  LDD1578  [16]
 LDCM0375  CL106 HEK-293T C188(1.06)  LDD1579  [16]
 LDCM0376  CL107 HEK-293T C188(1.01)  LDD1580  [16]
 LDCM0377  CL108 HEK-293T C188(1.07)  LDD1581  [16]
 LDCM0378  CL109 HEK-293T C188(0.99)  LDD1582  [16]
 LDCM0379  CL11 HEK-293T C188(0.98)  LDD1583  [16]
 LDCM0380  CL110 HEK-293T C188(0.96)  LDD1584  [16]
 LDCM0381  CL111 HEK-293T C188(0.87)  LDD1585  [16]
 LDCM0382  CL112 HEK-293T C188(1.02)  LDD1586  [16]
 LDCM0383  CL113 HEK-293T C188(0.99)  LDD1587  [16]
 LDCM0384  CL114 HEK-293T C188(0.88)  LDD1588  [16]
 LDCM0385  CL115 HEK-293T C188(0.88)  LDD1589  [16]
 LDCM0386  CL116 HEK-293T C188(1.00)  LDD1590  [16]
 LDCM0387  CL117 HEK-293T C188(1.03)  LDD1591  [16]
 LDCM0388  CL118 HEK-293T C188(0.92)  LDD1592  [16]
 LDCM0389  CL119 HEK-293T C188(0.97)  LDD1593  [16]
 LDCM0390  CL12 HEK-293T C188(0.95)  LDD1594  [16]
 LDCM0391  CL120 HEK-293T C188(1.04)  LDD1595  [16]
 LDCM0392  CL121 HEK-293T C188(1.02)  LDD1596  [16]
 LDCM0393  CL122 HEK-293T C188(0.98)  LDD1597  [16]
 LDCM0394  CL123 HEK-293T C188(0.94)  LDD1598  [16]
 LDCM0395  CL124 HEK-293T C188(0.98)  LDD1599  [16]
 LDCM0396  CL125 HEK-293T C188(0.95)  LDD1600  [16]
 LDCM0397  CL126 HEK-293T C188(1.00)  LDD1601  [16]
 LDCM0398  CL127 HEK-293T C188(0.98)  LDD1602  [16]
 LDCM0399  CL128 HEK-293T C188(1.00)  LDD1603  [16]
 LDCM0400  CL13 HEK-293T C188(0.88)  LDD1604  [16]
 LDCM0401  CL14 HEK-293T C188(0.87)  LDD1605  [16]
 LDCM0402  CL15 HEK-293T C188(0.79)  LDD1606  [16]
 LDCM0403  CL16 HEK-293T C188(1.02)  LDD1607  [16]
 LDCM0404  CL17 HEK-293T C188(0.87)  LDD1608  [16]
 LDCM0405  CL18 HEK-293T C188(0.88)  LDD1609  [16]
 LDCM0406  CL19 HEK-293T C188(0.99)  LDD1610  [16]
 LDCM0407  CL2 HEK-293T C188(0.85)  LDD1611  [16]
 LDCM0408  CL20 HEK-293T C188(1.07)  LDD1612  [16]
 LDCM0409  CL21 HEK-293T C188(0.91)  LDD1613  [16]
 LDCM0410  CL22 HEK-293T C188(1.09)  LDD1614  [16]
 LDCM0411  CL23 HEK-293T C188(1.05)  LDD1615  [16]
 LDCM0412  CL24 HEK-293T C188(1.12)  LDD1616  [16]
 LDCM0413  CL25 HEK-293T C188(0.99)  LDD1617  [16]
 LDCM0414  CL26 HEK-293T C188(1.05)  LDD1618  [16]
 LDCM0415  CL27 HEK-293T C188(0.94)  LDD1619  [16]
 LDCM0416  CL28 HEK-293T C188(0.99)  LDD1620  [16]
 LDCM0417  CL29 HEK-293T C188(1.07)  LDD1621  [16]
 LDCM0418  CL3 HEK-293T C188(0.92)  LDD1622  [16]
 LDCM0419  CL30 HEK-293T C188(1.00)  LDD1623  [16]
 LDCM0420  CL31 HEK-293T C188(1.09)  LDD1624  [16]
 LDCM0421  CL32 HEK-293T C188(1.07)  LDD1625  [16]
 LDCM0422  CL33 HEK-293T C188(0.88)  LDD1626  [16]
 LDCM0423  CL34 HEK-293T C188(1.17)  LDD1627  [16]
 LDCM0424  CL35 HEK-293T C188(1.04)  LDD1628  [16]
 LDCM0425  CL36 HEK-293T C188(1.11)  LDD1629  [16]
 LDCM0426  CL37 HEK-293T C188(1.07)  LDD1630  [16]
 LDCM0428  CL39 HEK-293T C188(1.08)  LDD1632  [16]
 LDCM0429  CL4 HEK-293T C188(0.95)  LDD1633  [16]
 LDCM0430  CL40 HEK-293T C188(1.07)  LDD1634  [16]
 LDCM0431  CL41 HEK-293T C188(0.95)  LDD1635  [16]
 LDCM0432  CL42 HEK-293T C188(1.06)  LDD1636  [16]
 LDCM0433  CL43 HEK-293T C188(1.10)  LDD1637  [16]
 LDCM0434  CL44 HEK-293T C188(1.16)  LDD1638  [16]
 LDCM0435  CL45 HEK-293T C188(1.00)  LDD1639  [16]
 LDCM0436  CL46 HEK-293T C188(1.15)  LDD1640  [16]
 LDCM0437  CL47 HEK-293T C188(1.07)  LDD1641  [16]
 LDCM0438  CL48 HEK-293T C188(1.08)  LDD1642  [16]
 LDCM0439  CL49 HEK-293T C188(0.89)  LDD1643  [16]
 LDCM0440  CL5 HEK-293T C188(0.90)  LDD1644  [16]
 LDCM0441  CL50 HEK-293T C188(0.94)  LDD1645  [16]
 LDCM0443  CL52 HEK-293T C188(0.93)  LDD1646  [16]
 LDCM0444  CL53 HEK-293T C188(0.82)  LDD1647  [16]
 LDCM0445  CL54 HEK-293T C188(0.80)  LDD1648  [16]
 LDCM0446  CL55 HEK-293T C188(0.99)  LDD1649  [16]
 LDCM0447  CL56 HEK-293T C188(0.98)  LDD1650  [16]
 LDCM0448  CL57 HEK-293T C188(0.88)  LDD1651  [16]
 LDCM0449  CL58 HEK-293T C188(1.01)  LDD1652  [16]
 LDCM0450  CL59 HEK-293T C188(1.01)  LDD1653  [16]
 LDCM0451  CL6 HEK-293T C188(0.86)  LDD1654  [16]
 LDCM0452  CL60 HEK-293T C188(1.02)  LDD1655  [16]
 LDCM0453  CL61 HEK-293T C188(1.03)  LDD1656  [16]
 LDCM0454  CL62 HEK-293T C188(1.03)  LDD1657  [16]
 LDCM0455  CL63 HEK-293T C188(0.96)  LDD1658  [16]
 LDCM0456  CL64 HEK-293T C188(1.02)  LDD1659  [16]
 LDCM0457  CL65 HEK-293T C188(0.99)  LDD1660  [16]
 LDCM0458  CL66 HEK-293T C188(0.89)  LDD1661  [16]
 LDCM0459  CL67 HEK-293T C188(1.01)  LDD1662  [16]
 LDCM0460  CL68 HEK-293T C188(0.98)  LDD1663  [16]
 LDCM0461  CL69 HEK-293T C188(1.03)  LDD1664  [16]
 LDCM0462  CL7 HEK-293T C188(0.96)  LDD1665  [16]
 LDCM0463  CL70 HEK-293T C188(1.17)  LDD1666  [16]
 LDCM0464  CL71 HEK-293T C188(1.01)  LDD1667  [16]
 LDCM0465  CL72 HEK-293T C188(1.14)  LDD1668  [16]
 LDCM0466  CL73 HEK-293T C188(0.94)  LDD1669  [16]
 LDCM0467  CL74 HEK-293T C188(0.96)  LDD1670  [16]
 LDCM0469  CL76 HEK-293T C188(0.99)  LDD1672  [16]
 LDCM0470  CL77 HEK-293T C188(0.87)  LDD1673  [16]
 LDCM0471  CL78 HEK-293T C188(0.86)  LDD1674  [16]
 LDCM0472  CL79 HEK-293T C188(0.97)  LDD1675  [16]
 LDCM0473  CL8 HEK-293T C188(0.74)  LDD1676  [16]
 LDCM0474  CL80 HEK-293T C188(0.95)  LDD1677  [16]
 LDCM0475  CL81 HEK-293T C188(0.96)  LDD1678  [16]
 LDCM0476  CL82 HEK-293T C188(0.99)  LDD1679  [16]
 LDCM0477  CL83 HEK-293T C188(0.89)  LDD1680  [16]
 LDCM0478  CL84 HEK-293T C188(1.02)  LDD1681  [16]
 LDCM0479  CL85 HEK-293T C188(0.91)  LDD1682  [16]
 LDCM0480  CL86 HEK-293T C188(0.91)  LDD1683  [16]
 LDCM0481  CL87 HEK-293T C188(0.93)  LDD1684  [16]
 LDCM0482  CL88 HEK-293T C188(0.99)  LDD1685  [16]
 LDCM0483  CL89 HEK-293T C188(0.95)  LDD1686  [16]
 LDCM0484  CL9 HEK-293T C188(0.91)  LDD1687  [16]
 LDCM0485  CL90 HEK-293T C188(0.81)  LDD1688  [16]
 LDCM0486  CL91 HEK-293T C188(1.01)  LDD1689  [16]
 LDCM0487  CL92 HEK-293T C188(1.02)  LDD1690  [16]
 LDCM0488  CL93 HEK-293T C188(0.91)  LDD1691  [16]
 LDCM0489  CL94 HEK-293T C188(1.02)  LDD1692  [16]
 LDCM0490  CL95 HEK-293T C188(0.90)  LDD1693  [16]
 LDCM0491  CL96 HEK-293T C188(0.92)  LDD1694  [16]
 LDCM0492  CL97 HEK-293T C188(0.96)  LDD1695  [16]
 LDCM0493  CL98 HEK-293T C188(0.93)  LDD1696  [16]
 LDCM0494  CL99 HEK-293T C188(0.87)  LDD1697  [16]
 LDCM0495  E2913 HEK-293T C188(0.91)  LDD1698  [16]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [5]
 LDCM0625  F8 Ramos C188(1.12)  LDD2187  [17]
 LDCM0572  Fragment10 Ramos C188(0.73)  LDD2189  [17]
 LDCM0573  Fragment11 Ramos C188(0.07)  LDD2190  [17]
 LDCM0574  Fragment12 Ramos C188(0.71)  LDD2191  [17]
 LDCM0575  Fragment13 Ramos C188(0.81)  LDD2192  [17]
 LDCM0576  Fragment14 Ramos C188(0.86)  LDD2193  [17]
 LDCM0579  Fragment20 Ramos C188(0.69)  LDD2194  [17]
 LDCM0580  Fragment21 Ramos C188(0.93)  LDD2195  [17]
 LDCM0582  Fragment23 Ramos C188(0.83)  LDD2196  [17]
 LDCM0578  Fragment27 Ramos C188(0.89)  LDD2197  [17]
 LDCM0588  Fragment30 Ramos C188(0.96)  LDD2199  [17]
 LDCM0589  Fragment31 Ramos C188(0.72)  LDD2200  [17]
 LDCM0590  Fragment32 Ramos C188(0.68)  LDD2201  [17]
 LDCM0468  Fragment33 HEK-293T C188(0.85)  LDD1671  [16]
 LDCM0596  Fragment38 Ramos C188(0.76)  LDD2203  [17]
 LDCM0566  Fragment4 Ramos C188(1.01)  LDD2184  [17]
 LDCM0427  Fragment51 HEK-293T C188(1.09)  LDD1631  [16]
 LDCM0610  Fragment52 Ramos C188(0.95)  LDD2204  [17]
 LDCM0614  Fragment56 Ramos C188(0.90)  LDD2205  [17]
 LDCM0569  Fragment7 Ramos C188(0.95)  LDD2186  [17]
 LDCM0571  Fragment9 Ramos C188(0.73)  LDD2188  [17]
 LDCM0022  KB02 HEK-293T C188(0.94)  LDD1492  [16]
 LDCM0023  KB03 HEK-293T C188(1.05)  LDD1497  [16]
 LDCM0024  KB05 MEWO C227(1.86)  LDD3319  [4]
 LDCM0628  OTUB2-COV-1 HEK-293T C188(0.55)  LDD2207  [18]
 LDCM0131  RA190 MM1.R C188(1.03)  LDD0304  [19]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytochrome b-c1 complex subunit 7 (UQCRB) UQCRB/QCR7 family P14927
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nucleoporin p58/p45 (NUP58) NUP58 family Q9BVL2
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Krueppel-like factor 11 (KLF11) Sp1 C2H2-type zinc-finger protein family O14901
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Intercellular adhesion molecule 5 (ICAM5) ICAM family Q9UMF0
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Axonemal dynein light intermediate polypeptide 1 (DNALI1) Inner dynein arm light chain family O14645
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (SMARCD1) SMARCD family Q96GM5
Protein VAC14 homolog (VAC14) VAC14 family Q08AM6

References

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2 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
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Mass spectrometry data entry: PXD028853
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
10 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
11 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
12 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
16 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
17 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
18 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
19 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.