Details of the Target

General Information of Target

Target ID LDTP03643
Target Name Deoxycytidylate deaminase (DCTD)
Gene Name DCTD
Gene ID 1635
Synonyms
Deoxycytidylate deaminase; EC 3.5.4.12; dCMP deaminase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSEVSCKKRDDYLEWPEYFMAVAFLSAQRSKDPNSQVGACIVNSENKIVGIGYNGMPNGC
SDDVLPWRRTAENKLDTKYPYVCHAELNAIMNKNSTDVKGCSMYVALFPCNECAKLIIQA
GIKEVIFMSDKYHDSDEATAARLLFNMAGVTFRKFIPKCSKIVIDFDSINSRPSQKLQ
Target Bioclass
Enzyme
Family
Cytidine and deoxycytidylate deaminase family
Function
Catalyzes the deamination of dCMP to dUMP, providing the nucleoside monophosphate substrate for the thymidylate synthase/TYMS. Also, part of a nucleotide salvage pathway that eliminates epigenetically modified 5-hydroxymethyl-dCMP (hmdCMP) in a two-step process entailing deamination to cytotoxic 5-hydroxymethyl-dUMP (hmdUMP), followed by its hydrolysis into 5-hydroxymethyluracil (hmU) and 2-deoxy-D-ribose 5-phosphate (deoxyribosephosphate). Catalyzes the first step in that pathway, the deamination of 5-hydroxymethyl-dCMP (hmdCMP).
Uniprot ID
P32321
Ensemble ID
ENST00000357067.7
HGNC ID
HGNC:2710
ChEMBL ID
CHEMBL5675

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K176(7.98)  LDD0277  [2]
DBIA
 Probe Info  		C71(1.21); C94(0.88)  LDD3310  [3]
BTD
 Probe Info  		C40(1.16)  LDD1700  [4]
EA-probe
 Probe Info  		N.A.  LDD0440  [5]
HHS-475
 Probe Info  		Y132(0.90); Y79(0.93)  LDD0264  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C60(0.00); C40(0.00); C83(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [8]
Lodoacetamide azide
 Probe Info  		C60(0.00); C40(0.00); C83(0.00)  LDD0037  [7]
NAIA_4
 Probe Info  		N.A.  LDD2226  [9]
IPM
 Probe Info  		N.A.  LDD0147  [10]
PF-06672131
 Probe Info  		N.A.  LDD0152  [11]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [12]
W1
 Probe Info  		N.A.  LDD0236  [13]
AOyne
 Probe Info  		14.30  LDD0443  [14]
NAIA_5
 Probe Info  		C101(0.00); C40(0.00); C6(0.00)  LDD2223  [9]
HHS-465
 Probe Info  		K78(0.00); Y79(0.00)  LDD2240  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C40(0.31)  LDD2142  [4]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C40(0.99)  LDD2130  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C40(0.99)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C40(1.16)  LDD2152  [4]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C40(0.42)  LDD2132  [4]
 LDCM0214  AC1 HEK-293T C83(1.03); C60(0.80)  LDD1507  [16]
 LDCM0215  AC10 HEK-293T C83(1.10)  LDD1508  [16]
 LDCM0226  AC11 HEK-293T C83(0.98); C60(1.03)  LDD1509  [16]
 LDCM0237  AC12 HEK-293T C83(0.94); C60(0.96)  LDD1510  [16]
 LDCM0259  AC14 HEK-293T C83(0.97); C60(0.76)  LDD1512  [16]
 LDCM0270  AC15 HEK-293T C83(1.02); C60(1.02)  LDD1513  [16]
 LDCM0276  AC17 HEK-293T C83(0.99); C60(1.24)  LDD1515  [16]
 LDCM0277  AC18 HEK-293T C83(0.96)  LDD1516  [16]
 LDCM0278  AC19 HEK-293T C83(0.93); C60(1.05)  LDD1517  [16]
 LDCM0279  AC2 HEK-293T C83(1.06)  LDD1518  [16]
 LDCM0280  AC20 HEK-293T C83(1.04); C60(0.97)  LDD1519  [16]
 LDCM0281  AC21 HEK-293T C83(1.04); C60(0.88)  LDD1520  [16]
 LDCM0282  AC22 HEK-293T C83(1.02); C60(0.99)  LDD1521  [16]
 LDCM0283  AC23 HEK-293T C83(1.04); C60(0.97)  LDD1522  [16]
 LDCM0284  AC24 HEK-293T C83(1.03)  LDD1523  [16]
 LDCM0285  AC25 HEK-293T C83(1.08); C60(0.98)  LDD1524  [16]
 LDCM0286  AC26 HEK-293T C83(0.96)  LDD1525  [16]
 LDCM0287  AC27 HEK-293T C83(0.92); C60(1.06)  LDD1526  [16]
 LDCM0288  AC28 HEK-293T C83(1.00); C60(1.15)  LDD1527  [16]
 LDCM0289  AC29 HEK-293T C83(1.01); C60(0.95)  LDD1528  [16]
 LDCM0290  AC3 HEK-293T C83(1.03); C60(0.95)  LDD1529  [16]
 LDCM0291  AC30 HEK-293T C83(1.03); C60(0.88)  LDD1530  [16]
 LDCM0292  AC31 HEK-293T C83(1.02); C60(0.94)  LDD1531  [16]
 LDCM0293  AC32 HEK-293T C83(1.06)  LDD1532  [16]
 LDCM0294  AC33 HEK-293T C83(1.07); C60(0.84)  LDD1533  [16]
 LDCM0295  AC34 HEK-293T C83(1.10)  LDD1534  [16]
 LDCM0296  AC35 HEK-293T C83(1.01); C60(0.96)  LDD1535  [16]
 LDCM0297  AC36 HEK-293T C83(0.94); C60(0.97)  LDD1536  [16]
 LDCM0298  AC37 HEK-293T C83(1.04); C60(1.31)  LDD1537  [16]
 LDCM0299  AC38 HEK-293T C83(0.97); C60(0.91)  LDD1538  [16]
 LDCM0300  AC39 HEK-293T C83(1.04); C60(1.10)  LDD1539  [16]
 LDCM0301  AC4 HEK-293T C83(0.88); C60(1.17)  LDD1540  [16]
 LDCM0302  AC40 HEK-293T C83(1.00)  LDD1541  [16]
 LDCM0303  AC41 HEK-293T C83(1.08); C60(0.93)  LDD1542  [16]
 LDCM0304  AC42 HEK-293T C83(1.14)  LDD1543  [16]
 LDCM0305  AC43 HEK-293T C83(0.97); C60(1.01)  LDD1544  [16]
 LDCM0306  AC44 HEK-293T C83(0.98); C60(1.12)  LDD1545  [16]
 LDCM0307  AC45 HEK-293T C83(1.02); C60(1.03)  LDD1546  [16]
 LDCM0308  AC46 HEK-293T C83(0.97); C60(0.97)  LDD1547  [16]
 LDCM0309  AC47 HEK-293T C83(1.03); C60(1.07)  LDD1548  [16]
 LDCM0310  AC48 HEK-293T C83(1.01)  LDD1549  [16]
 LDCM0311  AC49 HEK-293T C83(1.07); C60(0.96)  LDD1550  [16]
 LDCM0312  AC5 HEK-293T C83(1.08); C60(0.94)  LDD1551  [16]
 LDCM0313  AC50 HEK-293T C83(1.09)  LDD1552  [16]
 LDCM0314  AC51 HEK-293T C83(0.96); C60(0.93)  LDD1553  [16]
 LDCM0315  AC52 HEK-293T C83(0.96); C60(1.08)  LDD1554  [16]
 LDCM0316  AC53 HEK-293T C83(1.07); C60(1.08)  LDD1555  [16]
 LDCM0317  AC54 HEK-293T C83(0.99); C60(1.10)  LDD1556  [16]
 LDCM0318  AC55 HEK-293T C83(1.00); C60(1.04)  LDD1557  [16]
 LDCM0319  AC56 HEK-293T C83(1.04)  LDD1558  [16]
 LDCM0320  AC57 HEK-293T C83(1.01); C60(1.05)  LDD1559  [16]
 LDCM0321  AC58 HEK-293T C83(1.03)  LDD1560  [16]
 LDCM0322  AC59 HEK-293T C83(0.95); C60(0.92)  LDD1561  [16]
 LDCM0323  AC6 HEK-293T C83(0.97); C60(0.94)  LDD1562  [16]
 LDCM0324  AC60 HEK-293T C83(0.95); C60(1.08)  LDD1563  [16]
 LDCM0325  AC61 HEK-293T C83(1.00); C60(1.05)  LDD1564  [16]
 LDCM0326  AC62 HEK-293T C83(0.95); C60(1.20)  LDD1565  [16]
 LDCM0327  AC63 HEK-293T C83(1.05); C60(1.13)  LDD1566  [16]
 LDCM0328  AC64 HEK-293T C83(1.01)  LDD1567  [16]
 LDCM0334  AC7 HEK-293T C83(0.99); C60(1.11)  LDD1568  [16]
 LDCM0345  AC8 HEK-293T C83(1.00)  LDD1569  [16]
 LDCM0520  AKOS000195272 MDA-MB-231 C40(0.67)  LDD2113  [4]
 LDCM0248  AKOS034007472 HEK-293T C83(1.00); C60(0.79)  LDD1511  [16]
 LDCM0356  AKOS034007680 HEK-293T C83(1.07); C60(1.30)  LDD1570  [16]
 LDCM0275  AKOS034007705 HEK-293T C83(1.00)  LDD1514  [16]
 LDCM0156  Aniline NCI-H1299 14.16  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C40(0.56)  LDD2091  [4]
 LDCM0630  CCW28-3 231MFP C60(0.86)  LDD2214  [17]
 LDCM0632  CL-Sc Hep-G2 C6(20.00)  LDD2227  [9]
 LDCM0367  CL1 HEK-293T C83(0.93)  LDD1571  [16]
 LDCM0368  CL10 HEK-293T C83(0.81); C60(0.64)  LDD1572  [16]
 LDCM0369  CL100 HEK-293T C83(1.06)  LDD1573  [16]
 LDCM0370  CL101 HEK-293T C83(0.92)  LDD1574  [16]
 LDCM0371  CL102 HEK-293T C83(1.00)  LDD1575  [16]
 LDCM0372  CL103 HEK-293T C83(1.04); C60(0.92)  LDD1576  [16]
 LDCM0373  CL104 HEK-293T C83(1.06)  LDD1577  [16]
 LDCM0374  CL105 HEK-293T C83(0.93)  LDD1578  [16]
 LDCM0375  CL106 HEK-293T C83(0.98)  LDD1579  [16]
 LDCM0376  CL107 HEK-293T C83(0.95); C60(0.83)  LDD1580  [16]
 LDCM0377  CL108 HEK-293T C83(1.07)  LDD1581  [16]
 LDCM0378  CL109 HEK-293T C83(1.05)  LDD1582  [16]
 LDCM0379  CL11 HEK-293T C83(1.02); C60(1.27)  LDD1583  [16]
 LDCM0380  CL110 HEK-293T C83(0.93)  LDD1584  [16]
 LDCM0381  CL111 HEK-293T C83(0.94); C60(0.86)  LDD1585  [16]
 LDCM0382  CL112 HEK-293T C83(0.97)  LDD1586  [16]
 LDCM0383  CL113 HEK-293T C83(0.98)  LDD1587  [16]
 LDCM0384  CL114 HEK-293T C83(0.93)  LDD1588  [16]
 LDCM0385  CL115 HEK-293T C83(1.10); C60(0.92)  LDD1589  [16]
 LDCM0386  CL116 HEK-293T C83(0.98)  LDD1590  [16]
 LDCM0387  CL117 HEK-293T C83(0.94)  LDD1591  [16]
 LDCM0388  CL118 HEK-293T C83(1.01)  LDD1592  [16]
 LDCM0389  CL119 HEK-293T C83(0.99); C60(0.87)  LDD1593  [16]
 LDCM0390  CL12 HEK-293T C83(1.05)  LDD1594  [16]
 LDCM0391  CL120 HEK-293T C83(1.13)  LDD1595  [16]
 LDCM0392  CL121 HEK-293T C83(0.95)  LDD1596  [16]
 LDCM0393  CL122 HEK-293T C83(1.04)  LDD1597  [16]
 LDCM0394  CL123 HEK-293T C83(1.00); C60(0.94)  LDD1598  [16]
 LDCM0395  CL124 HEK-293T C83(1.05)  LDD1599  [16]
 LDCM0396  CL125 HEK-293T C83(0.96)  LDD1600  [16]
 LDCM0397  CL126 HEK-293T C83(1.06)  LDD1601  [16]
 LDCM0398  CL127 HEK-293T C83(1.01); C60(0.98)  LDD1602  [16]
 LDCM0399  CL128 HEK-293T C83(1.00)  LDD1603  [16]
 LDCM0400  CL13 HEK-293T C83(0.93)  LDD1604  [16]
 LDCM0401  CL14 HEK-293T C83(1.08)  LDD1605  [16]
 LDCM0402  CL15 HEK-293T C83(1.01); C60(0.10)  LDD1606  [16]
 LDCM0403  CL16 HEK-293T C83(1.10)  LDD1607  [16]
 LDCM0404  CL17 HEK-293T C83(1.06); C60(0.78)  LDD1608  [16]
 LDCM0405  CL18 HEK-293T C83(1.22)  LDD1609  [16]
 LDCM0406  CL19 HEK-293T C83(0.92); C60(1.04)  LDD1610  [16]
 LDCM0407  CL2 HEK-293T C83(1.11)  LDD1611  [16]
 LDCM0408  CL20 HEK-293T C83(0.92); C60(1.09)  LDD1612  [16]
 LDCM0409  CL21 HEK-293T C83(0.92); C60(0.89)  LDD1613  [16]
 LDCM0410  CL22 HEK-293T C83(0.93); C60(0.93)  LDD1614  [16]
 LDCM0411  CL23 HEK-293T C83(1.11); C60(1.03)  LDD1615  [16]
 LDCM0412  CL24 HEK-293T C83(1.01)  LDD1616  [16]
 LDCM0413  CL25 HEK-293T C83(0.93)  LDD1617  [16]
 LDCM0414  CL26 HEK-293T C83(1.08)  LDD1618  [16]
 LDCM0415  CL27 HEK-293T C83(1.09); C60(0.80)  LDD1619  [16]
 LDCM0416  CL28 HEK-293T C83(1.01)  LDD1620  [16]
 LDCM0417  CL29 HEK-293T C83(1.03); C60(0.14)  LDD1621  [16]
 LDCM0418  CL3 HEK-293T C83(1.08); C60(0.88)  LDD1622  [16]
 LDCM0419  CL30 HEK-293T C83(1.11)  LDD1623  [16]
 LDCM0420  CL31 HEK-293T C83(0.92); C60(0.90)  LDD1624  [16]
 LDCM0421  CL32 HEK-293T C83(0.97); C60(1.00)  LDD1625  [16]
 LDCM0422  CL33 HEK-293T C83(0.87); C60(0.66)  LDD1626  [16]
 LDCM0423  CL34 HEK-293T C83(0.93); C60(0.83)  LDD1627  [16]
 LDCM0424  CL35 HEK-293T C83(1.07); C60(0.94)  LDD1628  [16]
 LDCM0425  CL36 HEK-293T C83(0.96)  LDD1629  [16]
 LDCM0426  CL37 HEK-293T C83(0.99)  LDD1630  [16]
 LDCM0428  CL39 HEK-293T C83(1.04); C60(0.61)  LDD1632  [16]
 LDCM0429  CL4 HEK-293T C83(1.15)  LDD1633  [16]
 LDCM0430  CL40 HEK-293T C83(1.06)  LDD1634  [16]
 LDCM0431  CL41 HEK-293T C83(1.12); C60(0.84)  LDD1635  [16]
 LDCM0432  CL42 HEK-293T C83(1.10)  LDD1636  [16]
 LDCM0433  CL43 HEK-293T C83(0.96); C60(1.05)  LDD1637  [16]
 LDCM0434  CL44 HEK-293T C83(0.96); C60(0.90)  LDD1638  [16]
 LDCM0435  CL45 HEK-293T C83(0.90); C60(0.62)  LDD1639  [16]
 LDCM0436  CL46 HEK-293T C83(1.00); C60(0.91)  LDD1640  [16]
 LDCM0437  CL47 HEK-293T C83(1.10); C60(1.17)  LDD1641  [16]
 LDCM0438  CL48 HEK-293T C83(0.97)  LDD1642  [16]
 LDCM0439  CL49 HEK-293T C83(0.95)  LDD1643  [16]
 LDCM0440  CL5 HEK-293T C83(1.14); C60(0.97)  LDD1644  [16]
 LDCM0441  CL50 HEK-293T C83(1.03)  LDD1645  [16]
 LDCM0443  CL52 HEK-293T C83(1.14)  LDD1646  [16]
 LDCM0444  CL53 HEK-293T C83(1.02); C60(0.92)  LDD1647  [16]
 LDCM0445  CL54 HEK-293T C83(1.03)  LDD1648  [16]
 LDCM0446  CL55 HEK-293T C83(0.95); C60(1.00)  LDD1649  [16]
 LDCM0447  CL56 HEK-293T C83(0.98); C60(0.98)  LDD1650  [16]
 LDCM0448  CL57 HEK-293T C83(0.83); C60(0.81)  LDD1651  [16]
 LDCM0449  CL58 HEK-293T C83(0.94); C60(0.88)  LDD1652  [16]
 LDCM0450  CL59 HEK-293T C83(1.04); C60(1.15)  LDD1653  [16]
 LDCM0451  CL6 HEK-293T C83(1.09)  LDD1654  [16]
 LDCM0452  CL60 HEK-293T C83(1.03)  LDD1655  [16]
 LDCM0453  CL61 HEK-293T C83(0.91)  LDD1656  [16]
 LDCM0454  CL62 HEK-293T C83(1.10)  LDD1657  [16]
 LDCM0455  CL63 HEK-293T C83(1.07); C60(0.80)  LDD1658  [16]
 LDCM0456  CL64 HEK-293T C83(1.03)  LDD1659  [16]
 LDCM0457  CL65 HEK-293T C83(1.04); C60(0.88)  LDD1660  [16]
 LDCM0458  CL66 HEK-293T C83(1.07)  LDD1661  [16]
 LDCM0459  CL67 HEK-293T C83(0.93); C60(1.09)  LDD1662  [16]
 LDCM0460  CL68 HEK-293T C83(0.93); C60(0.90)  LDD1663  [16]
 LDCM0461  CL69 HEK-293T C83(0.73); C60(0.81)  LDD1664  [16]
 LDCM0462  CL7 HEK-293T C83(0.84); C60(1.09)  LDD1665  [16]
 LDCM0463  CL70 HEK-293T C83(0.93); C60(0.96)  LDD1666  [16]
 LDCM0464  CL71 HEK-293T C83(1.02); C60(1.14)  LDD1667  [16]
 LDCM0465  CL72 HEK-293T C83(0.97)  LDD1668  [16]
 LDCM0466  CL73 HEK-293T C83(0.95)  LDD1669  [16]
 LDCM0467  CL74 HEK-293T C83(1.07)  LDD1670  [16]
 LDCM0469  CL76 HEK-293T C83(1.06)  LDD1672  [16]
 LDCM0470  CL77 HEK-293T C83(1.02); C60(0.62)  LDD1673  [16]
 LDCM0471  CL78 HEK-293T C83(1.17)  LDD1674  [16]
 LDCM0472  CL79 HEK-293T C83(0.89); C60(0.87)  LDD1675  [16]
 LDCM0473  CL8 HEK-293T C83(0.68); C60(1.02)  LDD1676  [16]
 LDCM0474  CL80 HEK-293T C83(0.98); C60(0.92)  LDD1677  [16]
 LDCM0475  CL81 HEK-293T C83(1.00); C60(1.07)  LDD1678  [16]
 LDCM0476  CL82 HEK-293T C83(0.98); C60(0.96)  LDD1679  [16]
 LDCM0477  CL83 HEK-293T C83(0.98); C60(1.08)  LDD1680  [16]
 LDCM0478  CL84 HEK-293T C83(0.95)  LDD1681  [16]
 LDCM0479  CL85 HEK-293T C83(1.03)  LDD1682  [16]
 LDCM0480  CL86 HEK-293T C83(1.11)  LDD1683  [16]
 LDCM0481  CL87 HEK-293T C83(1.08); C60(0.73)  LDD1684  [16]
 LDCM0482  CL88 HEK-293T C83(1.10)  LDD1685  [16]
 LDCM0483  CL89 HEK-293T C83(1.05); C60(0.89)  LDD1686  [16]
 LDCM0484  CL9 HEK-293T C83(1.03); C60(0.92)  LDD1687  [16]
 LDCM0485  CL90 HEK-293T C83(0.96)  LDD1688  [16]
 LDCM0486  CL91 HEK-293T C83(1.11); C60(0.99)  LDD1689  [16]
 LDCM0487  CL92 HEK-293T C83(0.97); C60(0.85)  LDD1690  [16]
 LDCM0488  CL93 HEK-293T C83(0.96); C60(0.75)  LDD1691  [16]
 LDCM0489  CL94 HEK-293T C83(0.99); C60(0.77)  LDD1692  [16]
 LDCM0490  CL95 HEK-293T C83(0.87); C60(0.84)  LDD1693  [16]
 LDCM0491  CL96 HEK-293T C83(0.95)  LDD1694  [16]
 LDCM0492  CL97 HEK-293T C83(0.86)  LDD1695  [16]
 LDCM0493  CL98 HEK-293T C83(1.03)  LDD1696  [16]
 LDCM0494  CL99 HEK-293T C83(1.03); C60(0.94)  LDD1697  [16]
 LDCM0495  E2913 HEK-293T C83(1.12); C60(0.84)  LDD1698  [16]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C83(1.29); C40(1.10)  LDD1702  [4]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [5]
 LDCM0625  F8 Ramos C60(1.37)  LDD2187  [18]
 LDCM0573  Fragment11 Ramos C60(0.80); C83(2.57)  LDD2190  [18]
 LDCM0576  Fragment14 Ramos C60(0.54); C83(0.76)  LDD2193  [18]
 LDCM0586  Fragment28 Ramos C60(0.77); C83(1.00)  LDD2198  [18]
 LDCM0468  Fragment33 HEK-293T C83(1.13); C60(0.81)  LDD1671  [16]
 LDCM0566  Fragment4 Ramos C60(0.74); C83(0.68)  LDD2184  [18]
 LDCM0427  Fragment51 HEK-293T C83(1.01)  LDD1631  [16]
 LDCM0569  Fragment7 Ramos C60(0.61); C83(0.67)  LDD2186  [18]
 LDCM0116  HHS-0101 DM93 Y132(0.90); Y79(0.93)  LDD0264  [6]
 LDCM0117  HHS-0201 DM93 Y79(0.49); Y132(1.04)  LDD0265  [6]
 LDCM0118  HHS-0301 DM93 Y132(0.71); Y79(1.39)  LDD0266  [6]
 LDCM0119  HHS-0401 DM93 Y132(0.88); Y79(0.90)  LDD0267  [6]
 LDCM0120  HHS-0701 DM93 Y132(0.74); Y79(1.09)  LDD0268  [6]
 LDCM0022  KB02 HEK-293T C83(1.02); C60(0.90)  LDD1492  [16]
 LDCM0023  KB03 HEK-293T C83(1.00); C60(1.09)  LDD1497  [16]
 LDCM0024  KB05 COLO792 C71(1.21); C94(0.88)  LDD3310  [3]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C40(1.13)  LDD2102  [4]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C40(0.71)  LDD2121  [4]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C40(0.61)  LDD2089  [4]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C40(1.18)  LDD2090  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C40(0.97)  LDD2093  [4]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C40(0.85)  LDD2097  [4]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C40(1.06)  LDD2098  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C40(0.96)  LDD2099  [4]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C40(0.87)  LDD2101  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C40(1.00)  LDD2107  [4]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C40(0.43)  LDD2108  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C40(0.47)  LDD2109  [4]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C40(0.62)  LDD2110  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C40(1.03)  LDD2111  [4]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C40(0.55)  LDD2114  [4]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C40(0.49)  LDD2115  [4]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C40(0.55)  LDD2118  [4]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C40(0.78)  LDD2120  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C40(0.79)  LDD2123  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C40(0.84)  LDD2125  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C40(1.02)  LDD2127  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C40(0.73)  LDD2128  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C40(0.92)  LDD2129  [4]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C40(0.55)  LDD2133  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C40(0.53)  LDD2134  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C40(0.98)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C40(0.91)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C40(0.85)  LDD2137  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C40(1.16)  LDD1700  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C40(0.60)  LDD2141  [4]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C40(0.84)  LDD2143  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C40(2.13)  LDD2144  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C40(0.67)  LDD2146  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C40(0.56)  LDD2150  [4]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C40(0.58); C159(0.89)  LDD2151  [4]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C40(1.62)  LDD2153  [4]
 LDCM0131  RA190 MM1.R C60(0.93)  LDD0304  [19]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Deoxycytidylate deaminase (DCTD) Cytidine and deoxycytidylate deaminase family P32321
Proteasome subunit alpha type-1 (PSMA1) Peptidase T1A family P25786
Thioredoxin, mitochondrial (TXN2) Thioredoxin family Q99757
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Syntenin-1 (SDCBP) . O00560
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Golgi reassembly-stacking protein 2 (GORASP2) GORASP family Q9H8Y8
Fibroblast growth factor 12 (FGF12) Heparin-binding growth factors family P61328
Mitochondrial assembly of ribosomal large subunit protein 1 (MALSU1) Iojap/RsfS family Q96EH3
PRKCA-binding protein (PICK1) . Q9NRD5

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cytarabine Small molecular drug DB00987

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
12 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
13 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
16 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
17 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
18 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
19 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.