Details of the Target

General Information of Target

Target ID LDTP15097
Target Name All-trans-retinol 13,14-reductase (RETSAT)
Gene Name RETSAT
Gene ID 54884
Synonyms
PPSIG; All-trans-retinol 13,14-reductase; EC 1.3.99.23; All-trans-13,14-dihydroretinol saturase; RetSat; PPAR-alpha-regulated and starvation-induced gene protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDPSADTWDLSSPLISLWINRFYIYLGFAVSISLWICVQIVIEMQGFATVLAEAVTSLDL
PVAIINLKEYDPDDHLIEEVTSKNVCVFLVATYTDGLPTESAEWFCKWLEEASIDFRFGK
TYLKGMRDAVFGLGNSAYASHFNKVGKNVDKWLWMLGVHRVMSRGEGDCDVVKSKHGSIE
ANFRAWKTKFISQLQALQKGERKKSCGGHCKKGKCESHQHGSEEREEGSQEQDELHHRDT
KEEEPFESSSEEEFGGEDHQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGR
NEDGERRAMITPALREALTKQVDAPRERSLLQTHILWNESHRCMETTPSLACANKCVFCW
WHHNNPVGTEWLWKMDQPEMILKEAIENHQNMIKQFKGVPGVKAERFEEGMTVKHCALSL
VGEPIMYPEINRFLKLLHQCKISSFLVTNAQFPAEIRNLEPVTQLYVSVDASTKDSLKKI
DRPLFKDFWQQFLDSLKALAVKQQRTVYRLMLVKAWNVDELQAYAQLVSLGNPDFIEVKG
VTYCRESSASSLTMAHVPWHEEVVQFVRELVDLIPEYEIACEHEHSNCLLIAHRKFKIGG
EWWTWIDYNRFQELIQEYEDSGGSKTFSAKDYMARTPHWALFGANERSFDPKDTRHQRKN
KSKAISGC
Target Bioclass
Enzyme
Family
Carotenoid/retinoid oxidoreductase family, CrtISO subfamily
Subcellular location
Endoplasmic reticulum membrane
Function
Catalyzes the saturation of all-trans-retinol to all-trans-13,14-dihydroretinol. Does not exhibit any activity toward all-trans-retinoic acid, nor 9-cis, 11-cis or 13-cis-retinol isomers. May play a role in the metabolism of vitamin A. Independently of retinol conversion, may regulate liver metabolism upstream of MLXIPL/ChREBP. May play a role in adipocyte differentiation.
Uniprot ID
Q6NUM9
Ensemble ID
ENST00000295802.9
HGNC ID
HGNC:25991

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.L255H DBIA    Probe Info 
JHH4 SNV: p.A441P DBIA    Probe Info 
LU65 SNV: p.C18F DBIA    Probe Info 
MCC26 SNV: p.H121Y DBIA    Probe Info 
MFE319 SNV: p.G311R DBIA    Probe Info 
NCIH1048 SNV: p.V515A DBIA    Probe Info 
OV90 Insertion: p.C225QfsTer21 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 24 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
YN-1
 Probe Info  		100.00  LDD0444  [2]
YN-4
 Probe Info  		100.00  LDD0445  [2]
STPyne
 Probe Info  		K101(10.00); K597(5.23)  LDD0277  [3]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [4]
BTD
 Probe Info  		C106(0.88)  LDD2095  [5]
AHL-Pu-1
 Probe Info  		C534(2.06); C370(3.06)  LDD0171  [6]
HPAP
 Probe Info  		3.79  LDD0062  [7]
EA-probe
 Probe Info  		N.A.  LDD0440  [8]
DBIA
 Probe Info  		C105(1.06); C106(1.06); C534(0.92)  LDD0078  [9]
ATP probe
 Probe Info  		K101(0.00); K111(0.00)  LDD0199  [10]
IA-alkyne
 Probe Info  		C547(0.00); C347(0.00); C534(0.00)  LDD0162  [11]
ATP probe
 Probe Info  		N.A.  LDD0035  [12]
NAIA_4
 Probe Info  		N.A.  LDD2226  [13]
TFBX
 Probe Info  		C547(0.00); C225(0.00); C370(0.00)  LDD0027  [14]
WYneN
 Probe Info  		N.A.  LDD0021  [15]
Compound 10
 Probe Info  		N.A.  LDD2216  [16]
Compound 11
 Probe Info  		N.A.  LDD2213  [16]
IPM
 Probe Info  		C105(0.00); C534(0.00)  LDD0005  [15]
Acrolein
 Probe Info  		N.A.  LDD0217  [17]
Methacrolein
 Probe Info  		C534(0.00); C105(0.00)  LDD0218  [17]
W1
 Probe Info  		N.A.  LDD0236  [18]
AOyne
 Probe Info  		15.00  LDD0443  [19]
NAIA_5
 Probe Info  		N.A.  LDD2223  [13]
PAL-AfBPP Probe
Click To Hide/Show 25 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		6.28  LDD1714  [20]
C022
 Probe Info  		9.71  LDD1728  [20]
C071
 Probe Info  		8.11  LDD1767  [20]
C158
 Probe Info  		11.88  LDD1838  [20]
C159
 Probe Info  		8.40  LDD1839  [20]
C160
 Probe Info  		8.11  LDD1840  [20]
C161
 Probe Info  		24.59  LDD1841  [20]
C218
 Probe Info  		12.13  LDD1892  [20]
C220
 Probe Info  		11.71  LDD1894  [20]
C226
 Probe Info  		5.66  LDD1899  [20]
C228
 Probe Info  		16.91  LDD1901  [20]
C280
 Probe Info  		12.47  LDD1950  [20]
C296
 Probe Info  		11.47  LDD1966  [20]
C348
 Probe Info  		11.24  LDD2009  [20]
C349
 Probe Info  		11.79  LDD2010  [20]
C350
 Probe Info  		23.75  LDD2011  [20]
C353
 Probe Info  		6.41  LDD2014  [20]
C355
 Probe Info  		27.28  LDD2016  [20]
C383
 Probe Info  		11.16  LDD2042  [20]
C388
 Probe Info  		43.41  LDD2047  [20]
C391
 Probe Info  		20.39  LDD2050  [20]
C429
 Probe Info  		17.15  LDD2084  [20]
FFF probe11
 Probe Info  		20.00  LDD0471  [21]
FFF probe2
 Probe Info  		20.00  LDD0463  [21]
OEA-DA
 Probe Info  		12.35  LDD0046  [22]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C106(0.88)  LDD2095  [5]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C332(0.78)  LDD2117  [5]
 LDCM0026  4SU-RNA+native RNA DM93 C534(2.06); C370(3.06)  LDD0171  [6]
 LDCM0214  AC1 HCT 116 C105(1.40); C106(1.46); C393(0.75); C534(1.07)  LDD0531  [9]
 LDCM0215  AC10 HCT 116 C105(0.92); C106(1.00); C534(1.09); C547(0.88)  LDD0532  [9]
 LDCM0216  AC100 HCT 116 C105(1.06); C106(1.08); C534(0.94); C547(0.95)  LDD0533  [9]
 LDCM0217  AC101 HCT 116 C105(0.96); C106(0.97); C534(0.98); C547(1.17)  LDD0534  [9]
 LDCM0218  AC102 HCT 116 C105(0.94); C106(0.96); C534(1.01); C547(1.13)  LDD0535  [9]
 LDCM0219  AC103 HCT 116 C105(1.10); C106(1.12); C534(1.13); C547(1.22)  LDD0536  [9]
 LDCM0220  AC104 HCT 116 C105(0.93); C106(0.97); C534(1.05); C547(1.18)  LDD0537  [9]
 LDCM0221  AC105 HCT 116 C105(0.96); C106(0.96); C534(0.99); C547(1.00)  LDD0538  [9]
 LDCM0222  AC106 HCT 116 C105(1.05); C106(1.09); C534(1.00); C547(1.07)  LDD0539  [9]
 LDCM0223  AC107 HCT 116 C105(1.17); C106(0.81); C534(1.16); C547(1.07)  LDD0540  [9]
 LDCM0224  AC108 HCT 116 C105(0.93); C106(0.88); C534(0.88); C547(0.91)  LDD0541  [9]
 LDCM0225  AC109 HCT 116 C105(0.88); C106(0.75); C534(0.90); C547(1.01)  LDD0542  [9]
 LDCM0226  AC11 HCT 116 C105(0.99); C106(1.10); C534(1.12); C547(0.88)  LDD0543  [9]
 LDCM0227  AC110 HCT 116 C105(0.95); C106(0.81); C534(0.98); C547(1.12)  LDD0544  [9]
 LDCM0228  AC111 HCT 116 C105(0.89); C106(0.81); C534(0.89); C547(1.25)  LDD0545  [9]
 LDCM0229  AC112 HCT 116 C105(1.02); C106(0.81); C534(1.03); C547(1.17)  LDD0546  [9]
 LDCM0230  AC113 HCT 116 C105(0.98); C106(0.98); C393(0.95); C534(1.08)  LDD0547  [9]
 LDCM0231  AC114 HCT 116 C105(1.17); C106(1.06); C393(1.15); C534(1.13)  LDD0548  [9]
 LDCM0232  AC115 HCT 116 C105(1.07); C106(1.17); C393(1.06); C534(1.28)  LDD0549  [9]
 LDCM0233  AC116 HCT 116 C105(1.01); C106(1.05); C393(1.91); C534(1.29)  LDD0550  [9]
 LDCM0234  AC117 HCT 116 C105(1.00); C106(1.06); C393(1.00); C534(1.04)  LDD0551  [9]
 LDCM0235  AC118 HCT 116 C105(0.98); C106(0.97); C393(1.20); C534(1.05)  LDD0552  [9]
 LDCM0236  AC119 HCT 116 C105(0.95); C106(1.08); C393(1.06); C534(1.12)  LDD0553  [9]
 LDCM0237  AC12 HCT 116 C105(1.07); C106(1.21); C534(1.06); C547(1.06)  LDD0554  [9]
 LDCM0238  AC120 HCT 116 C105(1.07); C106(1.11); C393(1.40); C534(1.21)  LDD0555  [9]
 LDCM0239  AC121 HCT 116 C105(0.97); C106(0.99); C393(0.81); C534(1.05)  LDD0556  [9]
 LDCM0240  AC122 HCT 116 C105(0.95); C106(1.08); C393(1.01); C534(1.08)  LDD0557  [9]
 LDCM0241  AC123 HCT 116 C105(0.96); C106(1.00); C393(0.74); C534(0.97)  LDD0558  [9]
 LDCM0242  AC124 HCT 116 C105(0.93); C106(0.93); C393(0.84); C534(0.93)  LDD0559  [9]
 LDCM0243  AC125 HCT 116 C105(0.97); C106(0.97); C393(1.23); C534(1.06)  LDD0560  [9]
 LDCM0244  AC126 HCT 116 C105(1.06); C106(1.07); C393(1.04); C534(1.22)  LDD0561  [9]
 LDCM0245  AC127 HCT 116 C105(1.04); C106(1.07); C393(0.93); C534(1.22)  LDD0562  [9]
 LDCM0246  AC128 HCT 116 C105(1.23); C106(1.15); C534(1.11); C547(1.08)  LDD0563  [9]
 LDCM0247  AC129 HCT 116 C105(1.07); C106(1.02); C534(0.92); C547(0.98)  LDD0564  [9]
 LDCM0249  AC130 HCT 116 C105(1.23); C106(1.23); C534(1.02); C547(1.12)  LDD0566  [9]
 LDCM0250  AC131 HCT 116 C105(0.99); C106(1.01); C534(0.93); C547(1.50)  LDD0567  [9]
 LDCM0251  AC132 HCT 116 C105(1.01); C106(1.02); C534(1.00); C547(0.87)  LDD0568  [9]
 LDCM0252  AC133 HCT 116 C105(1.10); C106(1.07); C534(1.08); C547(0.89)  LDD0569  [9]
 LDCM0253  AC134 HCT 116 C105(1.19); C106(1.16); C534(1.13); C547(1.00)  LDD0570  [9]
 LDCM0254  AC135 HCT 116 C105(1.09); C106(1.11); C534(0.99); C547(1.13)  LDD0571  [9]
 LDCM0255  AC136 HCT 116 C105(1.13); C106(1.22); C534(1.17); C547(1.12)  LDD0572  [9]
 LDCM0256  AC137 HCT 116 C105(1.02); C106(1.03); C534(1.07); C547(0.93)  LDD0573  [9]
 LDCM0257  AC138 HCT 116 C105(1.19); C106(1.30); C534(1.09); C547(1.00)  LDD0574  [9]
 LDCM0258  AC139 HCT 116 C105(1.27); C106(1.35); C534(1.14); C547(1.02)  LDD0575  [9]
 LDCM0259  AC14 HCT 116 C105(0.81); C106(0.86); C534(1.14); C547(1.09)  LDD0576  [9]
 LDCM0260  AC140 HCT 116 C105(1.33); C106(1.42); C534(1.11); C547(1.05)  LDD0577  [9]
 LDCM0261  AC141 HCT 116 C105(1.34); C106(1.45); C534(1.07); C547(1.07)  LDD0578  [9]
 LDCM0262  AC142 HCT 116 C105(1.18); C106(1.28); C534(1.07); C547(0.71)  LDD0579  [9]
 LDCM0263  AC143 HCT 116 C105(1.06); C106(1.06); C547(1.13); C534(1.28)  LDD0580  [9]
 LDCM0264  AC144 HCT 116 C106(1.08); C105(1.12); C534(1.31); C547(1.48)  LDD0581  [9]
 LDCM0265  AC145 HCT 116 C106(1.03); C105(1.12); C534(1.27); C547(1.44)  LDD0582  [9]
 LDCM0266  AC146 HCT 116 C106(1.01); C105(1.17); C534(1.33); C547(1.40)  LDD0583  [9]
 LDCM0267  AC147 HCT 116 C106(1.03); C105(1.19); C534(1.29); C547(1.40)  LDD0584  [9]
 LDCM0268  AC148 HCT 116 C106(0.92); C105(1.02); C534(1.67); C547(2.10)  LDD0585  [9]
 LDCM0269  AC149 HCT 116 C106(1.04); C105(1.08); C534(1.47); C547(1.76)  LDD0586  [9]
 LDCM0270  AC15 HCT 116 C105(0.81); C106(0.93); C547(1.07); C534(1.20)  LDD0587  [9]
 LDCM0271  AC150 HCT 116 C547(1.20); C105(1.20); C106(1.23); C534(1.41)  LDD0588  [9]
 LDCM0272  AC151 HCT 116 C106(1.11); C105(1.22); C534(1.22); C547(1.28)  LDD0589  [9]
 LDCM0273  AC152 HCT 116 C106(1.05); C105(1.11); C534(1.38); C547(1.64)  LDD0590  [9]
 LDCM0274  AC153 HCT 116 C106(1.14); C105(1.60); C534(1.93); C547(2.35)  LDD0591  [9]
 LDCM0621  AC154 HCT 116 C105(1.23); C106(1.10); C534(1.52); C547(1.51)  LDD2158  [9]
 LDCM0622  AC155 HCT 116 C105(1.12); C106(1.20); C534(1.21); C547(1.46)  LDD2159  [9]
 LDCM0623  AC156 HCT 116 C105(1.06); C106(1.10); C534(1.22); C547(1.13)  LDD2160  [9]
 LDCM0624  AC157 HCT 116 C105(1.25); C106(1.11); C534(1.01); C547(1.62)  LDD2161  [9]
 LDCM0276  AC17 HCT 116 C547(0.95); C534(0.98); C105(1.01); C106(1.02)  LDD0593  [9]
 LDCM0277  AC18 HCT 116 C534(1.25); C547(1.28); C106(1.34); C105(1.34)  LDD0594  [9]
 LDCM0278  AC19 HCT 116 C534(0.95); C106(0.96); C105(0.97); C547(1.09)  LDD0595  [9]
 LDCM0279  AC2 HCT 116 C393(0.82); C547(0.89); C534(1.08); C105(1.13)  LDD0596  [9]
 LDCM0280  AC20 HCT 116 C534(0.96); C105(1.05); C106(1.05); C547(1.25)  LDD0597  [9]
 LDCM0281  AC21 HCT 116 C106(0.99); C105(1.00); C534(1.01); C547(1.16)  LDD0598  [9]
 LDCM0282  AC22 HCT 116 C534(0.91); C105(1.02); C106(1.02); C547(1.14)  LDD0599  [9]
 LDCM0283  AC23 HCT 116 C534(0.92); C106(1.00); C105(1.01); C547(1.33)  LDD0600  [9]
 LDCM0284  AC24 HCT 116 C534(0.86); C106(0.91); C105(0.94); C547(1.30)  LDD0601  [9]
 LDCM0285  AC25 HCT 116 C547(0.92); C106(0.98); C105(1.01); C534(1.11)  LDD0602  [9]
 LDCM0286  AC26 HCT 116 C547(0.84); C105(1.07); C106(1.09); C534(1.12)  LDD0603  [9]
 LDCM0287  AC27 HCT 116 C106(0.88); C105(0.89); C547(1.07); C534(1.12)  LDD0604  [9]
 LDCM0288  AC28 HCT 116 C547(0.87); C105(0.94); C106(0.99); C534(1.20)  LDD0605  [9]
 LDCM0289  AC29 HCT 116 C106(0.95); C105(0.95); C547(1.05); C534(1.18)  LDD0606  [9]
 LDCM0290  AC3 HCT 116 C393(0.87); C547(0.89); C534(1.04); C105(1.21)  LDD0607  [9]
 LDCM0291  AC30 HCT 116 C105(0.88); C106(0.89); C547(1.06); C534(1.15)  LDD0608  [9]
 LDCM0292  AC31 HCT 116 C105(1.00); C106(1.02); C547(1.04); C534(1.19)  LDD0609  [9]
 LDCM0293  AC32 HCT 116 C105(1.00); C106(1.02); C534(1.34); C547(1.35)  LDD0610  [9]
 LDCM0294  AC33 HCT 116 C105(0.85); C106(0.90); C547(1.03); C534(1.29)  LDD0611  [9]
 LDCM0295  AC34 HCT 116 C105(0.91); C106(0.98); C547(1.12); C534(1.48)  LDD0612  [9]
 LDCM0296  AC35 HCT 116 C105(0.92); C534(0.92); C106(0.93); C547(0.98)  LDD0613  [9]
 LDCM0297  AC36 HCT 116 C534(0.97); C105(0.98); C547(1.00); C106(1.02)  LDD0614  [9]
 LDCM0298  AC37 HCT 116 C534(0.94); C105(0.95); C547(1.02); C106(1.02)  LDD0615  [9]
 LDCM0299  AC38 HCT 116 C105(0.98); C106(0.98); C534(0.99); C547(1.13)  LDD0616  [9]
 LDCM0300  AC39 HCT 116 C534(1.06); C547(1.08); C105(1.08); C106(1.12)  LDD0617  [9]
 LDCM0301  AC4 HCT 116 C393(0.93); C547(1.03); C534(1.12); C105(1.25)  LDD0618  [9]
 LDCM0302  AC40 HCT 116 C534(0.94); C105(1.10); C106(1.13); C547(1.20)  LDD0619  [9]
 LDCM0303  AC41 HCT 116 C534(0.93); C105(1.05); C106(1.09); C547(1.27)  LDD0620  [9]
 LDCM0304  AC42 HCT 116 C105(1.01); C106(1.04); C534(1.08); C547(1.15)  LDD0621  [9]
 LDCM0305  AC43 HCT 116 C547(0.95); C534(0.98); C105(1.02); C106(1.06)  LDD0622  [9]
 LDCM0306  AC44 HCT 116 C534(0.90); C105(0.98); C106(1.03); C547(1.09)  LDD0623  [9]
 LDCM0307  AC45 HCT 116 C534(0.95); C547(0.95); C105(1.07); C106(1.14)  LDD0624  [9]
 LDCM0308  AC46 HCT 116 C547(0.97); C105(1.02); C106(1.09); C534(1.31)  LDD0625  [9]
 LDCM0309  AC47 HCT 116 C547(0.91); C534(1.02); C105(1.15); C106(1.16)  LDD0626  [9]
 LDCM0310  AC48 HCT 116 C547(0.92); C105(1.15); C106(1.28); C534(1.47)  LDD0627  [9]
 LDCM0311  AC49 HCT 116 C547(1.01); C105(1.16); C106(1.22); C534(1.29)  LDD0628  [9]
 LDCM0312  AC5 HCT 116 C393(0.93); C547(0.94); C534(1.13); C105(1.40)  LDD0629  [9]
 LDCM0313  AC50 HCT 116 C106(1.11); C105(1.11); C534(1.19); C547(1.23)  LDD0630  [9]
 LDCM0314  AC51 HCT 116 C534(0.84); C106(0.92); C105(0.95); C547(1.08)  LDD0631  [9]
 LDCM0315  AC52 HCT 116 C547(0.92); C534(0.96); C106(1.00); C105(1.01)  LDD0632  [9]
 LDCM0316  AC53 HCT 116 C106(1.04); C105(1.11); C547(1.15); C534(1.22)  LDD0633  [9]
 LDCM0317  AC54 HCT 116 C547(0.91); C105(1.01); C106(1.02); C534(1.15)  LDD0634  [9]
 LDCM0318  AC55 HCT 116 C105(1.11); C547(1.12); C106(1.16); C534(1.23)  LDD0635  [9]
 LDCM0319  AC56 HCT 116 C547(1.17); C105(1.33); C534(1.42); C106(1.46)  LDD0636  [9]
 LDCM0320  AC57 HCT 116 C534(1.06); C547(1.18); C105(1.26); C106(1.28)  LDD0637  [9]
 LDCM0321  AC58 HCT 116 C534(1.13); C547(1.27); C105(1.32); C106(1.35)  LDD0638  [9]
 LDCM0322  AC59 HCT 116 C547(1.18); C534(1.26); C105(1.43); C106(1.47)  LDD0639  [9]
 LDCM0323  AC6 HCT 116 C547(0.98); C105(1.07); C106(1.11); C534(1.14)  LDD0640  [9]
 LDCM0324  AC60 HCT 116 C534(1.15); C547(1.24); C105(1.36); C106(1.38)  LDD0641  [9]
 LDCM0325  AC61 HCT 116 C547(1.00); C534(1.27); C105(1.31); C106(1.39)  LDD0642  [9]
 LDCM0326  AC62 HCT 116 C547(1.02); C534(1.19); C105(1.54); C106(1.62)  LDD0643  [9]
 LDCM0327  AC63 HCT 116 C534(1.05); C547(1.33); C105(1.46); C106(1.58)  LDD0644  [9]
 LDCM0328  AC64 HCT 116 C547(1.16); C105(1.36); C106(1.45); C534(1.46)  LDD0645  [9]
 LDCM0329  AC65 HCT 116 C547(1.11); C534(1.39); C105(1.42); C106(1.43)  LDD0646  [9]
 LDCM0330  AC66 HCT 116 C534(1.26); C547(1.37); C105(1.41); C106(1.45)  LDD0647  [9]
 LDCM0331  AC67 HCT 116 C547(1.11); C534(1.37); C105(1.57); C106(1.63)  LDD0648  [9]
 LDCM0332  AC68 HCT 116 C393(0.82); C105(1.05); C106(1.06); C547(1.14)  LDD0649  [9]
 LDCM0333  AC69 HCT 116 C393(0.81); C547(1.19); C105(1.24); C534(1.26)  LDD0650  [9]
 LDCM0334  AC7 HCT 116 C547(1.12); C534(1.20); C105(1.29); C106(1.30)  LDD0651  [9]
 LDCM0335  AC70 HCT 116 C547(0.82); C393(1.06); C105(1.20); C106(1.24)  LDD0652  [9]
 LDCM0336  AC71 HCT 116 C393(0.70); C105(0.96); C106(0.98); C547(1.08)  LDD0653  [9]
 LDCM0337  AC72 HCT 116 C547(0.89); C105(1.14); C106(1.17); C393(1.19)  LDD0654  [9]
 LDCM0338  AC73 HCT 116 C547(0.93); C393(1.10); C105(1.25); C106(1.26)  LDD0655  [9]
 LDCM0339  AC74 HCT 116 C393(0.85); C547(1.17); C105(1.25); C106(1.28)  LDD0656  [9]
 LDCM0340  AC75 HCT 116 C393(0.89); C547(0.91); C105(1.27); C106(1.27)  LDD0657  [9]
 LDCM0341  AC76 HCT 116 C547(1.05); C106(1.05); C105(1.06); C393(1.17)  LDD0658  [9]
 LDCM0342  AC77 HCT 116 C393(1.02); C534(1.14); C105(1.15); C106(1.20)  LDD0659  [9]
 LDCM0343  AC78 HCT 116 C393(0.85); C547(1.12); C105(1.13); C106(1.17)  LDD0660  [9]
 LDCM0344  AC79 HCT 116 C393(0.79); C547(0.95); C105(1.01); C106(1.04)  LDD0661  [9]
 LDCM0345  AC8 HCT 116 C547(0.98); C105(1.06); C106(1.13); C534(1.24)  LDD0662  [9]
 LDCM0346  AC80 HCT 116 C105(1.01); C393(1.05); C106(1.05); C547(1.09)  LDD0663  [9]
 LDCM0347  AC81 HCT 116 C393(0.92); C547(0.95); C105(1.00); C106(1.03)  LDD0664  [9]
 LDCM0348  AC82 HCT 116 C547(0.97); C393(0.99); C105(1.40); C106(1.45)  LDD0665  [9]
 LDCM0349  AC83 HCT 116 C534(1.25); C105(1.36); C106(1.42); C547(1.56)  LDD0666  [9]
 LDCM0350  AC84 HCT 116 C534(1.32); C106(1.40); C105(1.41); C547(1.44)  LDD0667  [9]
 LDCM0351  AC85 HCT 116 C547(1.20); C534(1.21); C105(1.31); C106(1.41)  LDD0668  [9]
 LDCM0352  AC86 HCT 116 C534(1.08); C547(1.25); C105(1.26); C106(1.39)  LDD0669  [9]
 LDCM0353  AC87 HCT 116 C547(1.01); C534(1.01); C105(1.14); C106(1.30)  LDD0670  [9]
 LDCM0354  AC88 HCT 116 C534(1.11); C547(1.22); C105(1.25); C106(1.45)  LDD0671  [9]
 LDCM0355  AC89 HCT 116 C534(1.12); C105(1.22); C106(1.40); C547(1.41)  LDD0672  [9]
 LDCM0357  AC90 HCT 116 C547(0.80); C534(0.94); C105(1.20); C106(1.34)  LDD0674  [9]
 LDCM0358  AC91 HCT 116 C534(1.16); C105(1.32); C106(1.36); C547(1.49)  LDD0675  [9]
 LDCM0359  AC92 HCT 116 C534(1.06); C105(1.28); C547(1.40); C106(1.40)  LDD0676  [9]
 LDCM0360  AC93 HCT 116 C534(1.06); C105(1.17); C106(1.26); C547(1.26)  LDD0677  [9]
 LDCM0361  AC94 HCT 116 C534(1.07); C106(1.13); C547(1.20); C105(1.20)  LDD0678  [9]
 LDCM0362  AC95 HCT 116 C534(1.02); C547(1.20); C105(1.29); C106(1.33)  LDD0679  [9]
 LDCM0363  AC96 HCT 116 C534(0.95); C106(1.24); C547(1.25); C105(1.33)  LDD0680  [9]
 LDCM0364  AC97 HCT 116 C534(1.22); C105(1.34); C106(1.44); C547(1.76)  LDD0681  [9]
 LDCM0365  AC98 HCT 116 C106(0.99); C105(1.00); C547(1.18); C534(1.21)  LDD0682  [9]
 LDCM0366  AC99 HCT 116 C534(0.96); C105(0.99); C106(1.00); C547(1.10)  LDD0683  [9]
 LDCM0248  AKOS034007472 HCT 116 C105(0.92); C106(1.06); C534(1.06); C547(0.85)  LDD0565  [9]
 LDCM0356  AKOS034007680 HCT 116 C547(0.92); C105(1.00); C106(1.06); C534(1.11)  LDD0673  [9]
 LDCM0275  AKOS034007705 HCT 116 C105(0.88); C547(1.05); C106(1.05); C534(1.52)  LDD0592  [9]
 LDCM0156  Aniline NCI-H1299 11.75  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C105(1.06); C106(1.06); C534(0.92)  LDD0078  [9]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [17]
 LDCM0632  CL-Sc Hep-G2 C534(1.00)  LDD2227  [13]
 LDCM0367  CL1 HCT 116 C534(0.94); C393(1.03); C105(1.13); C106(1.13)  LDD0684  [9]
 LDCM0368  CL10 HCT 116 C393(0.96); C105(1.15); C106(1.15); C534(1.40)  LDD0685  [9]
 LDCM0369  CL100 HCT 116 C534(1.04); C547(1.06); C393(1.18); C105(1.52)  LDD0686  [9]
 LDCM0370  CL101 HCT 116 C105(1.01); C106(1.08); C534(1.16); C547(1.18)  LDD0687  [9]
 LDCM0371  CL102 HCT 116 C534(1.13); C547(1.22); C105(1.54); C106(1.65)  LDD0688  [9]
 LDCM0372  CL103 HCT 116 C106(0.98); C105(0.99); C534(1.05); C547(1.08)  LDD0689  [9]
 LDCM0373  CL104 HCT 116 C105(0.93); C534(0.95); C106(1.03); C547(1.14)  LDD0690  [9]
 LDCM0374  CL105 HCT 116 C534(1.01); C547(1.03); C105(1.80); C106(1.82)  LDD0691  [9]
 LDCM0375  CL106 HCT 116 C547(1.07); C534(1.21); C105(1.64); C106(1.65)  LDD0692  [9]
 LDCM0376  CL107 HCT 116 C547(0.96); C534(1.29); C105(1.32); C106(1.36)  LDD0693  [9]
 LDCM0377  CL108 HCT 116 C547(0.88); C105(1.19); C106(1.20); C534(1.38)  LDD0694  [9]
 LDCM0378  CL109 HCT 116 C534(1.05); C547(1.23); C106(1.50); C105(1.50)  LDD0695  [9]
 LDCM0379  CL11 HCT 116 C393(0.93); C534(1.17); C547(1.68); C105(2.13)  LDD0696  [9]
 LDCM0380  CL110 HCT 116 C534(1.20); C547(1.42); C106(1.49); C105(1.54)  LDD0697  [9]
 LDCM0381  CL111 HCT 116 C534(1.12); C105(1.39); C106(1.41); C547(1.44)  LDD0698  [9]
 LDCM0382  CL112 HCT 116 C534(1.06); C547(1.21); C106(1.25); C105(1.26)  LDD0699  [9]
 LDCM0383  CL113 HCT 116 C105(0.99); C106(1.02); C547(1.25); C534(1.33)  LDD0700  [9]
 LDCM0384  CL114 HCT 116 C534(1.40); C105(1.63); C106(1.67); C547(2.16)  LDD0701  [9]
 LDCM0385  CL115 HCT 116 C105(0.93); C106(0.95); C534(1.24); C547(1.32)  LDD0702  [9]
 LDCM0386  CL116 HCT 116 C105(0.96); C106(1.02); C534(1.18); C547(1.42)  LDD0703  [9]
 LDCM0387  CL117 HCT 116 C534(1.16); C547(1.38); C105(1.44); C106(1.48)  LDD0704  [9]
 LDCM0388  CL118 HCT 116 C534(0.94); C105(1.07); C547(1.08); C106(1.12)  LDD0705  [9]
 LDCM0389  CL119 HCT 116 C534(0.95); C547(0.99); C105(1.08); C106(1.15)  LDD0706  [9]
 LDCM0390  CL12 HCT 116 C105(0.92); C106(0.92); C393(1.19); C534(1.28)  LDD0707  [9]
 LDCM0391  CL120 HCT 116 C534(0.89); C105(1.07); C106(1.10); C547(1.15)  LDD0708  [9]
 LDCM0392  CL121 HCT 116 C534(0.92); C105(0.96); C547(1.02); C106(1.27)  LDD0709  [9]
 LDCM0393  CL122 HCT 116 C547(1.19); C534(1.21); C105(1.26); C106(1.31)  LDD0710  [9]
 LDCM0394  CL123 HCT 116 C534(1.30); C547(1.60); C105(2.32); C106(2.55)  LDD0711  [9]
 LDCM0395  CL124 HCT 116 C547(1.07); C106(1.30); C105(1.30); C534(1.37)  LDD0712  [9]
 LDCM0396  CL125 HCT 116 C534(1.12); C547(1.14); C106(1.21); C105(1.23)  LDD0713  [9]
 LDCM0397  CL126 HCT 116 C534(0.99); C547(1.53); C105(1.67); C106(1.87)  LDD0714  [9]
 LDCM0398  CL127 HCT 116 C534(1.12); C547(1.22); C105(1.29); C106(1.35)  LDD0715  [9]
 LDCM0399  CL128 HCT 116 C547(1.09); C534(1.23); C105(1.25); C106(1.30)  LDD0716  [9]
 LDCM0400  CL13 HCT 116 C105(1.03); C106(1.03); C534(1.17); C393(1.20)  LDD0717  [9]
 LDCM0401  CL14 HCT 116 C105(0.93); C106(0.93); C393(1.01); C534(1.01)  LDD0718  [9]
 LDCM0402  CL15 HCT 116 C393(0.96); C534(1.18); C105(1.53); C106(1.53)  LDD0719  [9]
 LDCM0403  CL16 HCT 116 C393(1.01); C105(1.03); C106(1.04); C547(1.27)  LDD0720  [9]
 LDCM0404  CL17 HCT 116 C393(0.72); C534(1.15); C547(1.48); C105(1.58)  LDD0721  [9]
 LDCM0405  CL18 HCT 116 C547(0.80); C534(0.99); C105(1.07); C106(1.07)  LDD0722  [9]
 LDCM0406  CL19 HCT 116 C534(0.92); C547(0.99); C105(1.02); C106(1.02)  LDD0723  [9]
 LDCM0407  CL2 HCT 116 C534(0.92); C105(1.01); C106(1.01); C547(1.07)  LDD0724  [9]
 LDCM0408  CL20 HCT 116 C534(0.98); C105(1.03); C106(1.03); C547(1.06)  LDD0725  [9]
 LDCM0409  CL21 HCT 116 C534(1.08); C393(1.15); C547(1.85); C105(3.54)  LDD0726  [9]
 LDCM0410  CL22 HCT 116 C534(0.93); C105(1.32); C106(1.32); C393(1.34)  LDD0727  [9]
 LDCM0411  CL23 HCT 116 C393(0.98); C105(1.06); C106(1.06); C534(1.07)  LDD0728  [9]
 LDCM0412  CL24 HCT 116 C105(1.18); C106(1.18); C393(1.35); C534(0.98)  LDD0729  [9]
 LDCM0413  CL25 HCT 116 C105(1.95); C106(1.95); C393(1.21); C534(1.10)  LDD0730  [9]
 LDCM0414  CL26 HCT 116 C105(1.23); C106(1.23); C393(1.01); C534(0.97)  LDD0731  [9]
 LDCM0415  CL27 HCT 116 C105(0.97); C106(0.97); C393(1.04); C534(0.96)  LDD0732  [9]
 LDCM0416  CL28 HCT 116 C105(1.10); C106(1.10); C393(1.14); C534(0.96)  LDD0733  [9]
 LDCM0417  CL29 HCT 116 C105(1.10); C106(1.10); C393(0.97); C534(0.94)  LDD0734  [9]
 LDCM0418  CL3 HCT 116 C105(1.07); C106(1.07); C393(0.90); C534(1.00)  LDD0735  [9]
 LDCM0419  CL30 HCT 116 C105(1.02); C106(1.02); C393(1.11); C534(0.92)  LDD0736  [9]
 LDCM0420  CL31 HCT 116 C105(1.15); C106(1.18); C393(1.26); C534(1.07)  LDD0737  [9]
 LDCM0421  CL32 HCT 116 C105(1.42); C106(1.32); C393(1.09); C534(1.05)  LDD0738  [9]
 LDCM0422  CL33 HCT 116 C105(2.32); C106(2.20); C393(0.76); C534(1.63)  LDD0739  [9]
 LDCM0423  CL34 HCT 116 C105(1.34); C106(1.42); C393(1.68); C534(1.29)  LDD0740  [9]
 LDCM0424  CL35 HCT 116 C105(1.17); C106(1.20); C393(0.95); C534(1.25)  LDD0741  [9]
 LDCM0425  CL36 HCT 116 C105(1.32); C106(1.39); C393(1.52); C534(1.33)  LDD0742  [9]
 LDCM0426  CL37 HCT 116 C105(1.32); C106(1.36); C393(1.16); C534(1.21)  LDD0743  [9]
 LDCM0428  CL39 HCT 116 C105(1.39); C106(1.42); C393(1.19); C534(1.21)  LDD0745  [9]
 LDCM0429  CL4 HCT 116 C105(1.55); C106(1.55); C393(0.87); C534(1.01)  LDD0746  [9]
 LDCM0430  CL40 HCT 116 C105(1.13); C106(1.32); C393(0.84); C534(1.36)  LDD0747  [9]
 LDCM0431  CL41 HCT 116 C105(1.28); C106(1.23); C393(0.88); C534(1.05)  LDD0748  [9]
 LDCM0432  CL42 HCT 116 C105(1.83); C106(1.87); C393(1.32); C534(1.70)  LDD0749  [9]
 LDCM0433  CL43 HCT 116 C105(1.28); C106(1.31); C393(1.13); C534(1.17)  LDD0750  [9]
 LDCM0434  CL44 HCT 116 C105(1.22); C106(1.22); C393(1.13); C534(1.30)  LDD0751  [9]
 LDCM0435  CL45 HCT 116 C105(1.29); C106(1.41); C393(1.07); C534(1.45)  LDD0752  [9]
 LDCM0436  CL46 HCT 116 C105(1.19); C106(1.22); C534(1.01); C547(1.00)  LDD0753  [9]
 LDCM0437  CL47 HCT 116 C105(1.09); C106(1.11); C534(0.94); C547(0.92)  LDD0754  [9]
 LDCM0438  CL48 HCT 116 C105(1.02); C106(1.02); C534(0.97); C547(1.07)  LDD0755  [9]
 LDCM0439  CL49 HCT 116 C105(1.07); C106(1.09); C534(0.93); C547(1.34)  LDD0756  [9]
 LDCM0440  CL5 HCT 116 C105(0.81); C106(0.81); C393(1.10); C534(1.00)  LDD0757  [9]
 LDCM0441  CL50 HCT 116 C105(1.20); C106(1.21); C534(0.93); C547(1.16)  LDD0758  [9]
 LDCM0442  CL51 HCT 116 C105(1.25); C106(1.28); C534(0.98); C547(0.92)  LDD0759  [9]
 LDCM0443  CL52 HCT 116 C105(1.15); C106(1.18); C534(1.03); C547(1.00)  LDD0760  [9]
 LDCM0444  CL53 HCT 116 C105(1.16); C106(1.16); C534(1.10); C547(1.38)  LDD0761  [9]
 LDCM0445  CL54 HCT 116 C105(1.04); C106(1.07); C534(1.03); C547(1.38)  LDD0762  [9]
 LDCM0446  CL55 HCT 116 C105(1.04); C106(1.06); C534(0.99); C547(1.13)  LDD0763  [9]
 LDCM0447  CL56 HCT 116 C105(1.03); C106(1.04); C534(1.08); C547(1.08)  LDD0764  [9]
 LDCM0448  CL57 HCT 116 C105(1.05); C106(1.06); C534(0.98); C547(1.24)  LDD0765  [9]
 LDCM0449  CL58 HCT 116 C105(1.01); C106(1.04); C534(0.94); C547(1.14)  LDD0766  [9]
 LDCM0450  CL59 HCT 116 C105(1.09); C106(1.11); C534(0.94); C547(1.00)  LDD0767  [9]
 LDCM0451  CL6 HCT 116 C105(1.14); C106(1.14); C393(1.13); C534(1.25)  LDD0768  [9]
 LDCM0452  CL60 HCT 116 C105(1.10); C106(1.11); C534(0.94); C547(1.26)  LDD0769  [9]
 LDCM0453  CL61 HCT 116 C105(0.98); C106(0.98); C393(1.69); C534(1.01)  LDD0770  [9]
 LDCM0454  CL62 HCT 116 C105(1.04); C106(1.04); C393(1.30); C534(1.09)  LDD0771  [9]
 LDCM0455  CL63 HCT 116 C105(1.23); C106(1.23); C393(1.08); C534(1.13)  LDD0772  [9]
 LDCM0456  CL64 HCT 116 C105(1.33); C106(1.33); C393(1.24); C534(1.31)  LDD0773  [9]
 LDCM0457  CL65 HCT 116 C105(1.02); C106(1.02); C393(1.17); C534(1.16)  LDD0774  [9]
 LDCM0458  CL66 HCT 116 C105(1.48); C106(1.48); C393(1.32); C534(1.32)  LDD0775  [9]
 LDCM0459  CL67 HCT 116 C105(1.08); C106(1.08); C393(1.10); C534(1.31)  LDD0776  [9]
 LDCM0460  CL68 HCT 116 C105(1.18); C106(1.18); C393(0.92); C534(1.17)  LDD0777  [9]
 LDCM0461  CL69 HCT 116 C105(1.23); C106(1.23); C393(1.10); C534(1.06)  LDD0778  [9]
 LDCM0462  CL7 HCT 116 C105(0.94); C106(0.94); C393(1.13); C534(1.15)  LDD0779  [9]
 LDCM0463  CL70 HCT 116 C105(1.20); C106(1.20); C393(1.16); C534(1.08)  LDD0780  [9]
 LDCM0464  CL71 HCT 116 C105(1.22); C106(1.22); C393(1.25); C534(1.20)  LDD0781  [9]
 LDCM0465  CL72 HCT 116 C105(1.02); C106(1.02); C393(1.33); C534(1.01)  LDD0782  [9]
 LDCM0466  CL73 HCT 116 C105(1.99); C106(1.99); C393(0.96); C534(1.27)  LDD0783  [9]
 LDCM0467  CL74 HCT 116 C105(1.04); C106(1.04); C393(1.02); C534(1.17)  LDD0784  [9]
 LDCM0469  CL76 HCT 116 C105(1.04); C106(1.04); C393(0.87); C534(1.10)  LDD0786  [9]
 LDCM0470  CL77 HCT 116 C105(1.77); C106(1.77); C393(0.88); C534(1.30)  LDD0787  [9]
 LDCM0471  CL78 HCT 116 C105(1.09); C106(1.09); C393(0.91); C534(1.31)  LDD0788  [9]
 LDCM0472  CL79 HCT 116 C105(1.12); C106(1.12); C393(0.87); C534(1.26)  LDD0789  [9]
 LDCM0473  CL8 HCT 116 C105(1.32); C106(1.32); C393(1.14); C534(1.46)  LDD0790  [9]
 LDCM0474  CL80 HCT 116 C105(1.10); C106(1.10); C393(0.88); C534(1.08)  LDD0791  [9]
 LDCM0475  CL81 HCT 116 C105(1.14); C106(1.14); C393(1.00); C534(1.27)  LDD0792  [9]
 LDCM0476  CL82 HCT 116 C105(1.19); C106(1.19); C393(0.86); C534(1.43)  LDD0793  [9]
 LDCM0477  CL83 HCT 116 C105(1.44); C106(1.44); C393(0.79); C534(1.32)  LDD0794  [9]
 LDCM0478  CL84 HCT 116 C105(1.89); C106(1.89); C393(1.00); C534(1.68)  LDD0795  [9]
 LDCM0479  CL85 HCT 116 C105(1.03); C106(1.03); C393(0.81); C534(1.17)  LDD0796  [9]
 LDCM0480  CL86 HCT 116 C105(0.97); C106(0.97); C393(0.74); C534(1.16)  LDD0797  [9]
 LDCM0481  CL87 HCT 116 C105(0.93); C106(0.93); C393(0.91); C534(1.18)  LDD0798  [9]
 LDCM0482  CL88 HCT 116 C105(1.18); C106(1.18); C393(1.12); C534(1.40)  LDD0799  [9]
 LDCM0483  CL89 HCT 116 C105(1.54); C106(1.54); C393(0.87); C534(1.67)  LDD0800  [9]
 LDCM0484  CL9 HCT 116 C105(1.17); C106(1.17); C393(1.00); C534(1.08)  LDD0801  [9]
 LDCM0485  CL90 HCT 116 C105(1.85); C106(1.85); C393(0.74); C534(1.45)  LDD0802  [9]
 LDCM0486  CL91 HCT 116 C105(1.18); C106(1.22); C393(0.74); C534(1.09)  LDD0803  [9]
 LDCM0487  CL92 HCT 116 C105(1.59); C106(1.64); C393(1.01); C534(1.06)  LDD0804  [9]
 LDCM0488  CL93 HCT 116 C105(1.34); C106(1.39); C393(0.85); C534(1.08)  LDD0805  [9]
 LDCM0489  CL94 HCT 116 C105(1.73); C106(1.73); C393(0.83); C534(1.32)  LDD0806  [9]
 LDCM0490  CL95 HCT 116 C105(1.89); C106(1.94); C393(0.93); C534(1.31)  LDD0807  [9]
 LDCM0491  CL96 HCT 116 C105(1.40); C106(1.43); C393(0.80); C534(1.03)  LDD0808  [9]
 LDCM0492  CL97 HCT 116 C105(1.75); C106(1.81); C393(0.81); C534(1.11)  LDD0809  [9]
 LDCM0493  CL98 HCT 116 C105(1.62); C106(1.68); C393(0.76); C534(1.10)  LDD0810  [9]
 LDCM0494  CL99 HCT 116 C105(1.30); C106(1.34); C393(0.82); C534(1.03)  LDD0811  [9]
 LDCM0495  E2913 HEK-293T C393(1.33); C347(0.90); C547(1.21); C105(1.16)  LDD1698  [23]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C332(2.63)  LDD1702  [5]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [8]
 LDCM0204  EV-97 T cell C547(4.43)  LDD0525  [24]
 LDCM0573  Fragment11 Ramos C547(1.58)  LDD2190  [25]
 LDCM0586  Fragment28 Ramos C547(0.91)  LDD2198  [25]
 LDCM0468  Fragment33 HCT 116 C105(1.09); C106(1.09); C393(1.47); C534(1.10)  LDD0785  [9]
 LDCM0566  Fragment4 Ramos C547(3.13)  LDD2184  [25]
 LDCM0427  Fragment51 HCT 116 C105(1.47); C106(1.57); C393(1.30); C534(1.61)  LDD0744  [9]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [4]
 LDCM0022  KB02 HCT 116 C105(20.00); C106(20.00)  LDD0080  [9]
 LDCM0023  KB03 HCT 116 C105(20.00); C106(20.00)  LDD0081  [9]
 LDCM0024  KB05 HCT 116 C105(6.93); C106(6.93)  LDD0082  [9]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C105(0.87)  LDD2097  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C332(0.94)  LDD2099  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C332(0.83)  LDD2107  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C332(0.59); C534(1.22)  LDD2109  [5]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C332(1.86)  LDD2115  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C332(0.70); C534(1.17); C105(0.75)  LDD2123  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C332(0.78)  LDD2125  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C332(0.78)  LDD2127  [5]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C332(1.43)  LDD2129  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C332(0.97); C534(1.34)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C332(1.03)  LDD2137  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C332(0.78)  LDD2140  [5]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C534(1.97)  LDD2144  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C105(0.87)  LDD2146  [5]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C534(0.86)  LDD2150  [5]
 LDCM0627  NUDT7-COV-1 HEK-293T C534(0.28); C547(0.07)  LDD2206  [26]
 LDCM0628  OTUB2-COV-1 HEK-293T C534(0.44)  LDD2207  [26]
 LDCM0014  Panhematin HEK-293T 3.79  LDD0062  [7]
 LDCM0021  THZ1 HCT 116 C534(0.93)  LDD2173  [9]
 LDCM0111  W14 Hep-G2 C547(11.42)  LDD0238  [18]
 LDCM0112  W16 Hep-G2 C547(1.11)  LDD0239  [18]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Vitamin A Small molecular drug DB00162

References

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2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
8 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
16 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
18 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
19 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
20 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
21 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
22 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
23 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
24 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
25 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
26 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.