Details of the Target

General Information of Target

Target ID LDTP06111
Target Name UDP-glucose 4-epimerase (GALE)
Gene Name GALE
Gene ID 2582
Synonyms
UDP-glucose 4-epimerase; EC 5.1.3.2; Galactowaldenase; UDP-N-acetylgalactosamine 4-epimerase; UDP-GalNAc 4-epimerase; UDP-N-acetylglucosamine 4-epimerase; UDP-GlcNAc 4-epimerase; EC 5.1.3.7; UDP-galactose 4-epimerase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSV
EFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMK
AHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNA
VLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRD
YIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARR
EGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQNPSGFGTQA
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
NAD(P)-dependent epimerase/dehydratase family
Function
Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.
TTD ID
T96014
Uniprot ID
Q14376
DrugMap ID
TTGRHIB
Ensemble ID
ENST00000374497.7
HGNC ID
HGNC:4116
ChEMBL ID
CHEMBL5843

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
EFO27 SNV: p.P139L DBIA    Probe Info 
HCT15 SNV: p.D303G DBIA    Probe Info 
HEC1 SNV: p.A84T .
HEC1B SNV: p.A84T IA-alkyne    Probe Info 
LNCaP clone FGC SNV: p.K120N DBIA    Probe Info 
MFE319 SNV: p.E63G DBIA    Probe Info 
MOLT4 SNV: p.G237C IA-alkyne    Probe Info 
NCIH716 SNV: p.A305P .
U2OS SNV: p.L116V DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y267(20.00); Y275(7.18)  LDD0257  [1]
ONAyne
 Probe Info  		K259(10.00)  LDD0275  [2]
IPM
 Probe Info  		C330(0.00); C172(0.00); C264(0.00); C262(0.00)  LDD0241  [3]
Probe 1
 Probe Info  		Y230(11.45)  LDD3495  [4]
m-APA
 Probe Info  		14.30  LDD0403  [5]
BTD
 Probe Info  		C264(0.73)  LDD2127  [6]
AHL-Pu-1
 Probe Info  		C196(3.21)  LDD0169  [7]
EA-probe
 Probe Info  		N.A.  LDD0440  [8]
HHS-482
 Probe Info  		Y211(1.21)  LDD0285  [9]
HHS-475
 Probe Info  		Y211(1.20)  LDD0264  [10]
Acrolein
 Probe Info  		N.A.  LDD0221  [11]
DBIA
 Probe Info  		C330(1.16)  LDD0080  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		C172(0.00); C330(0.00); C153(0.00); C307(0.00)  LDD0038  [13]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [14]
Lodoacetamide azide
 Probe Info  		C172(0.00); C330(0.00); C153(0.00); C307(0.00)  LDD0037  [13]
ATP probe
 Probe Info  		K249(0.00); K286(0.00)  LDD0035  [15]
NAIA_4
 Probe Info  		C172(0.00); C307(0.00)  LDD2226  [16]
AOyne
 Probe Info  		13.00  LDD0443  [17]
NAIA_5
 Probe Info  		C172(0.00); C262(0.00); C330(0.00)  LDD2223  [16]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C003
 Probe Info  		12.82  LDD1713  [18]
VE-P
 Probe Info  		N.A.  LDD0396  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C196(3.21)  LDD0169  [7]
 LDCM0214  AC1 PaTu 8988t C330(0.11)  LDD1093  [12]
 LDCM0215  AC10 HCT 116 C330(1.04)  LDD0532  [12]
 LDCM0216  AC100 HCT 116 C330(1.21)  LDD0533  [12]
 LDCM0217  AC101 HCT 116 C330(1.28)  LDD0534  [12]
 LDCM0218  AC102 HCT 116 C330(0.66)  LDD0535  [12]
 LDCM0219  AC103 HCT 116 C330(0.31)  LDD0536  [12]
 LDCM0220  AC104 HCT 116 C330(0.47)  LDD0537  [12]
 LDCM0221  AC105 HCT 116 C330(0.61)  LDD0538  [12]
 LDCM0222  AC106 HCT 116 C330(0.43)  LDD0539  [12]
 LDCM0223  AC107 HCT 116 C330(0.59)  LDD0540  [12]
 LDCM0224  AC108 HCT 116 C330(0.54)  LDD0541  [12]
 LDCM0225  AC109 HCT 116 C330(0.49)  LDD0542  [12]
 LDCM0226  AC11 HCT 116 C330(1.31)  LDD0543  [12]
 LDCM0227  AC110 HCT 116 C330(0.65)  LDD0544  [12]
 LDCM0228  AC111 HCT 116 C330(0.75)  LDD0545  [12]
 LDCM0229  AC112 HCT 116 C330(0.42)  LDD0546  [12]
 LDCM0230  AC113 HCT 116 C330(1.15)  LDD0547  [12]
 LDCM0231  AC114 HCT 116 C330(1.09)  LDD0548  [12]
 LDCM0232  AC115 HCT 116 C330(1.20)  LDD0549  [12]
 LDCM0233  AC116 HCT 116 C330(0.97)  LDD0550  [12]
 LDCM0234  AC117 HCT 116 C330(1.03)  LDD0551  [12]
 LDCM0235  AC118 HCT 116 C330(1.00)  LDD0552  [12]
 LDCM0236  AC119 HCT 116 C330(1.11)  LDD0553  [12]
 LDCM0237  AC12 HCT 116 C330(1.09)  LDD0554  [12]
 LDCM0238  AC120 HCT 116 C330(0.85)  LDD0555  [12]
 LDCM0239  AC121 HCT 116 C330(0.98)  LDD0556  [12]
 LDCM0240  AC122 HCT 116 C330(1.05)  LDD0557  [12]
 LDCM0241  AC123 HCT 116 C330(1.08)  LDD0558  [12]
 LDCM0242  AC124 HCT 116 C330(0.94)  LDD0559  [12]
 LDCM0243  AC125 HCT 116 C330(1.08)  LDD0560  [12]
 LDCM0244  AC126 HCT 116 C330(0.92)  LDD0561  [12]
 LDCM0245  AC127 HCT 116 C330(1.00)  LDD0562  [12]
 LDCM0246  AC128 HCT 116 C330(0.70)  LDD0563  [12]
 LDCM0247  AC129 HCT 116 C330(0.76)  LDD0564  [12]
 LDCM0249  AC130 HCT 116 C330(0.73)  LDD0566  [12]
 LDCM0250  AC131 HCT 116 C330(0.77)  LDD0567  [12]
 LDCM0251  AC132 HCT 116 C330(0.77)  LDD0568  [12]
 LDCM0252  AC133 HCT 116 C330(0.79)  LDD0569  [12]
 LDCM0253  AC134 HCT 116 C330(0.84)  LDD0570  [12]
 LDCM0254  AC135 HCT 116 C330(0.79)  LDD0571  [12]
 LDCM0255  AC136 HCT 116 C330(0.84)  LDD0572  [12]
 LDCM0256  AC137 HCT 116 C330(0.73)  LDD0573  [12]
 LDCM0257  AC138 HCT 116 C330(0.68)  LDD0574  [12]
 LDCM0258  AC139 HCT 116 C330(0.77)  LDD0575  [12]
 LDCM0259  AC14 HCT 116 C330(1.31)  LDD0576  [12]
 LDCM0260  AC140 HCT 116 C330(0.66)  LDD0577  [12]
 LDCM0261  AC141 HCT 116 C330(0.55)  LDD0578  [12]
 LDCM0262  AC142 HCT 116 C330(0.73)  LDD0579  [12]
 LDCM0263  AC143 HCT 116 C330(2.10)  LDD0580  [12]
 LDCM0264  AC144 HCT 116 C330(0.81)  LDD0581  [12]
 LDCM0265  AC145 HCT 116 C330(1.26)  LDD0582  [12]
 LDCM0266  AC146 HCT 116 C330(1.15)  LDD0583  [12]
 LDCM0267  AC147 HCT 116 C330(0.69)  LDD0584  [12]
 LDCM0268  AC148 HCT 116 C330(0.23)  LDD0585  [12]
 LDCM0269  AC149 HCT 116 C330(0.83)  LDD0586  [12]
 LDCM0270  AC15 HCT 116 C330(1.44)  LDD0587  [12]
 LDCM0271  AC150 HCT 116 C330(1.76)  LDD0588  [12]
 LDCM0272  AC151 HCT 116 C330(1.12)  LDD0589  [12]
 LDCM0273  AC152 HCT 116 C330(0.67)  LDD0590  [12]
 LDCM0274  AC153 HCT 116 C330(0.19)  LDD0591  [12]
 LDCM0621  AC154 HCT 116 C330(0.98)  LDD2158  [12]
 LDCM0622  AC155 HCT 116 C330(0.98)  LDD2159  [12]
 LDCM0623  AC156 HCT 116 C330(1.99)  LDD2160  [12]
 LDCM0624  AC157 HCT 116 C330(0.85)  LDD2161  [12]
 LDCM0276  AC17 PaTu 8988t C330(1.29)  LDD1155  [12]
 LDCM0277  AC18 PaTu 8988t C330(0.55)  LDD1156  [12]
 LDCM0278  AC19 PaTu 8988t C330(0.78)  LDD1157  [12]
 LDCM0279  AC2 PaTu 8988t C330(0.48)  LDD1158  [12]
 LDCM0280  AC20 PaTu 8988t C330(0.92)  LDD1159  [12]
 LDCM0281  AC21 PaTu 8988t C330(0.42)  LDD1160  [12]
 LDCM0282  AC22 PaTu 8988t C330(0.38)  LDD1161  [12]
 LDCM0283  AC23 PaTu 8988t C330(0.49)  LDD1162  [12]
 LDCM0284  AC24 PaTu 8988t C330(1.96)  LDD1163  [12]
 LDCM0285  AC25 HEK-293T C172(0.90); C330(0.88); C307(1.07)  LDD1524  [20]
 LDCM0286  AC26 HEK-293T C172(0.90); C330(0.93); C153(1.01); C307(1.02)  LDD1525  [20]
 LDCM0287  AC27 HEK-293T C172(0.97); C330(0.88); C153(1.07); C307(0.85)  LDD1526  [20]
 LDCM0288  AC28 HEK-293T C172(0.86); C330(0.89); C307(0.91); C196(1.01)  LDD1527  [20]
 LDCM0289  AC29 HEK-293T C172(0.84); C330(0.86); C153(1.32); C307(0.96)  LDD1528  [20]
 LDCM0290  AC3 PaTu 8988t C330(0.10)  LDD1169  [12]
 LDCM0291  AC30 HEK-293T C330(0.80); C153(0.73); C307(0.96); C196(0.83)  LDD1530  [20]
 LDCM0292  AC31 HEK-293T C330(0.91); C153(1.03); C307(1.02); C196(1.05)  LDD1531  [20]
 LDCM0293  AC32 HEK-293T C330(1.00); C153(1.22); C307(0.94); C196(1.03)  LDD1532  [20]
 LDCM0294  AC33 HEK-293T C172(0.94); C330(0.91); C307(1.13)  LDD1533  [20]
 LDCM0295  AC34 HEK-293T C172(0.97); C330(0.93); C153(0.96); C307(1.12)  LDD1534  [20]
 LDCM0296  AC35 HCT 116 C330(1.00)  LDD0613  [12]
 LDCM0297  AC36 HCT 116 C330(1.19)  LDD0614  [12]
 LDCM0298  AC37 HCT 116 C330(1.14)  LDD0615  [12]
 LDCM0299  AC38 HCT 116 C330(1.28)  LDD0616  [12]
 LDCM0300  AC39 HCT 116 C330(1.16)  LDD0617  [12]
 LDCM0301  AC4 PaTu 8988t C330(0.36)  LDD1180  [12]
 LDCM0302  AC40 HCT 116 C330(0.91)  LDD0619  [12]
 LDCM0303  AC41 HCT 116 C330(1.39)  LDD0620  [12]
 LDCM0304  AC42 HCT 116 C330(1.19)  LDD0621  [12]
 LDCM0305  AC43 HCT 116 C330(1.21)  LDD0622  [12]
 LDCM0306  AC44 HCT 116 C330(1.18)  LDD0623  [12]
 LDCM0307  AC45 HCT 116 C330(0.91)  LDD0624  [12]
 LDCM0308  AC46 HCT 116 C330(1.09)  LDD0625  [12]
 LDCM0309  AC47 HCT 116 C330(1.14)  LDD0626  [12]
 LDCM0310  AC48 HCT 116 C330(1.30)  LDD0627  [12]
 LDCM0311  AC49 HCT 116 C330(0.32)  LDD0628  [12]
 LDCM0312  AC5 PaTu 8988t C330(0.12)  LDD1191  [12]
 LDCM0313  AC50 HCT 116 C330(0.45)  LDD0630  [12]
 LDCM0314  AC51 HCT 116 C330(1.78)  LDD0631  [12]
 LDCM0315  AC52 HCT 116 C330(1.31)  LDD0632  [12]
 LDCM0316  AC53 HCT 116 C330(0.81)  LDD0633  [12]
 LDCM0317  AC54 HCT 116 C330(0.66)  LDD0634  [12]
 LDCM0318  AC55 HCT 116 C330(0.37)  LDD0635  [12]
 LDCM0319  AC56 HCT 116 C330(0.27)  LDD0636  [12]
 LDCM0320  AC57 HCT 116 C330(0.98)  LDD0637  [12]
 LDCM0321  AC58 HCT 116 C330(0.91)  LDD0638  [12]
 LDCM0322  AC59 HCT 116 C330(0.38)  LDD0639  [12]
 LDCM0323  AC6 HCT 116 C330(0.87)  LDD0640  [12]
 LDCM0324  AC60 HCT 116 C330(1.08)  LDD0641  [12]
 LDCM0325  AC61 HCT 116 C330(0.89)  LDD0642  [12]
 LDCM0326  AC62 HCT 116 C330(0.38)  LDD0643  [12]
 LDCM0327  AC63 HCT 116 C330(0.88)  LDD0644  [12]
 LDCM0328  AC64 HCT 116 C330(0.47)  LDD0645  [12]
 LDCM0329  AC65 HCT 116 C330(0.57)  LDD0646  [12]
 LDCM0330  AC66 HCT 116 C330(0.74)  LDD0647  [12]
 LDCM0331  AC67 HCT 116 C330(0.13)  LDD0648  [12]
 LDCM0334  AC7 HCT 116 C330(1.09)  LDD0651  [12]
 LDCM0345  AC8 HCT 116 C330(1.28)  LDD0662  [12]
 LDCM0349  AC83 HCT 116 C330(1.26)  LDD0666  [12]
 LDCM0350  AC84 HCT 116 C330(1.15)  LDD0667  [12]
 LDCM0351  AC85 HCT 116 C330(1.16)  LDD0668  [12]
 LDCM0352  AC86 HCT 116 C330(1.51)  LDD0669  [12]
 LDCM0353  AC87 HCT 116 C330(1.32)  LDD0670  [12]
 LDCM0354  AC88 HCT 116 C330(1.12)  LDD0671  [12]
 LDCM0355  AC89 HCT 116 C330(1.29)  LDD0672  [12]
 LDCM0357  AC90 HCT 116 C330(1.21)  LDD0674  [12]
 LDCM0358  AC91 HCT 116 C330(1.53)  LDD0675  [12]
 LDCM0359  AC92 HCT 116 C330(1.34)  LDD0676  [12]
 LDCM0360  AC93 HCT 116 C330(1.27)  LDD0677  [12]
 LDCM0361  AC94 HCT 116 C330(0.93)  LDD0678  [12]
 LDCM0362  AC95 HCT 116 C330(1.11)  LDD0679  [12]
 LDCM0363  AC96 HCT 116 C330(0.96)  LDD0680  [12]
 LDCM0364  AC97 HCT 116 C330(1.27)  LDD0681  [12]
 LDCM0365  AC98 HCT 116 C330(0.07)  LDD0682  [12]
 LDCM0366  AC99 HCT 116 C330(20.00)  LDD0683  [12]
 LDCM0248  AKOS034007472 HCT 116 C330(1.26)  LDD0565  [12]
 LDCM0356  AKOS034007680 HCT 116 C330(1.14)  LDD0673  [12]
 LDCM0275  AKOS034007705 HCT 116 C330(1.62)  LDD0592  [12]
 LDCM0156  Aniline NCI-H1299 14.30  LDD0403  [5]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [11]
 LDCM0367  CL1 HCT 116 C330(0.88)  LDD0684  [12]
 LDCM0368  CL10 HCT 116 C330(0.58)  LDD0685  [12]
 LDCM0369  CL100 PaTu 8988t C330(0.71)  LDD1248  [12]
 LDCM0370  CL101 HCT 116 C330(0.92)  LDD0687  [12]
 LDCM0371  CL102 HCT 116 C330(0.94)  LDD0688  [12]
 LDCM0372  CL103 HCT 116 C330(1.20)  LDD0689  [12]
 LDCM0373  CL104 HCT 116 C330(1.38)  LDD0690  [12]
 LDCM0374  CL105 PaTu 8988t C330(1.98)  LDD1253  [12]
 LDCM0375  CL106 PaTu 8988t C330(1.08)  LDD1254  [12]
 LDCM0376  CL107 PaTu 8988t C330(1.29)  LDD1255  [12]
 LDCM0377  CL108 PaTu 8988t C330(0.83)  LDD1256  [12]
 LDCM0378  CL109 PaTu 8988t C330(0.82)  LDD1257  [12]
 LDCM0379  CL11 HCT 116 C330(0.54)  LDD0696  [12]
 LDCM0380  CL110 PaTu 8988t C330(0.66)  LDD1259  [12]
 LDCM0381  CL111 PaTu 8988t C330(0.42)  LDD1260  [12]
 LDCM0382  CL112 HEK-293T C172(0.88); C330(0.88); C153(0.92); C307(0.94)  LDD1586  [20]
 LDCM0383  CL113 HEK-293T C172(1.13); C330(1.03); C153(0.89); C196(1.00)  LDD1587  [20]
 LDCM0384  CL114 HEK-293T C330(0.97); C153(1.05); C196(1.13)  LDD1588  [20]
 LDCM0385  CL115 HEK-293T C172(0.91); C330(0.92); C153(1.37); C307(1.00)  LDD1589  [20]
 LDCM0386  CL116 HEK-293T C172(0.99); C330(0.95); C153(0.86); C307(1.12)  LDD1590  [20]
 LDCM0387  CL117 HCT 116 C330(0.69)  LDD0704  [12]
 LDCM0388  CL118 HCT 116 C330(1.18)  LDD0705  [12]
 LDCM0389  CL119 HCT 116 C330(1.19)  LDD0706  [12]
 LDCM0390  CL12 HCT 116 C330(0.37)  LDD0707  [12]
 LDCM0391  CL120 HCT 116 C330(1.03)  LDD0708  [12]
 LDCM0392  CL121 HCT 116 C330(1.88)  LDD0709  [12]
 LDCM0393  CL122 HCT 116 C330(0.85)  LDD0710  [12]
 LDCM0394  CL123 HCT 116 C330(0.61)  LDD0711  [12]
 LDCM0395  CL124 HCT 116 C330(0.43)  LDD0712  [12]
 LDCM0396  CL125 HCT 116 C330(1.45)  LDD0713  [12]
 LDCM0397  CL126 HCT 116 C330(1.05)  LDD0714  [12]
 LDCM0398  CL127 HCT 116 C330(1.07)  LDD0715  [12]
 LDCM0399  CL128 HCT 116 C330(0.85)  LDD0716  [12]
 LDCM0400  CL13 HCT 116 C330(0.81)  LDD0717  [12]
 LDCM0401  CL14 HCT 116 C330(0.91)  LDD0718  [12]
 LDCM0402  CL15 HCT 116 C330(0.70)  LDD0719  [12]
 LDCM0403  CL16 HCT 116 C330(1.18)  LDD0720  [12]
 LDCM0404  CL17 HCT 116 C330(1.20)  LDD0721  [12]
 LDCM0405  CL18 HCT 116 C330(1.19)  LDD0722  [12]
 LDCM0406  CL19 HCT 116 C330(1.19)  LDD0723  [12]
 LDCM0407  CL2 HCT 116 C330(0.97)  LDD0724  [12]
 LDCM0408  CL20 HCT 116 C330(1.10)  LDD0725  [12]
 LDCM0409  CL21 HCT 116 C330(1.13)  LDD0726  [12]
 LDCM0410  CL22 HCT 116 C330(0.76)  LDD0727  [12]
 LDCM0411  CL23 HCT 116 C330(0.90)  LDD0728  [12]
 LDCM0412  CL24 HCT 116 C330(0.83)  LDD0729  [12]
 LDCM0413  CL25 HCT 116 C330(0.97)  LDD0730  [12]
 LDCM0414  CL26 HCT 116 C330(1.10)  LDD0731  [12]
 LDCM0415  CL27 HCT 116 C330(1.23)  LDD0732  [12]
 LDCM0416  CL28 HCT 116 C330(1.27)  LDD0733  [12]
 LDCM0417  CL29 HCT 116 C330(1.30)  LDD0734  [12]
 LDCM0418  CL3 HCT 116 C330(0.89)  LDD0735  [12]
 LDCM0419  CL30 HCT 116 C330(1.68)  LDD0736  [12]
 LDCM0420  CL31 HEK-293T C172(1.01); C330(1.00); C153(0.93); C307(1.14)  LDD1624  [20]
 LDCM0421  CL32 HEK-293T C172(0.99); C330(1.02); C307(1.17); C196(0.93)  LDD1625  [20]
 LDCM0422  CL33 HEK-293T C172(0.98); C330(0.92); C153(1.38); C307(1.08)  LDD1626  [20]
 LDCM0423  CL34 HEK-293T C330(0.93); C153(0.96); C307(1.18); C196(0.89)  LDD1627  [20]
 LDCM0424  CL35 HEK-293T C330(1.02); C153(0.99); C307(0.92); C196(1.01)  LDD1628  [20]
 LDCM0425  CL36 HEK-293T C330(1.08); C153(1.14); C307(1.19); C196(0.70)  LDD1629  [20]
 LDCM0426  CL37 HEK-293T C172(0.98); C330(1.08); C153(0.93); C196(1.11)  LDD1630  [20]
 LDCM0428  CL39 HEK-293T C172(1.03); C330(1.18); C153(1.21); C307(1.45)  LDD1632  [20]
 LDCM0429  CL4 HCT 116 C330(1.10)  LDD0746  [12]
 LDCM0430  CL40 HEK-293T C172(1.05); C330(0.94); C153(0.87); C307(1.11)  LDD1634  [20]
 LDCM0431  CL41 HEK-293T C172(0.92); C330(0.96); C307(0.83)  LDD1635  [20]
 LDCM0432  CL42 HEK-293T C172(1.03); C330(1.04); C153(0.94); C307(1.10)  LDD1636  [20]
 LDCM0433  CL43 HEK-293T C172(0.91); C330(0.92); C153(0.95); C307(0.90)  LDD1637  [20]
 LDCM0434  CL44 HEK-293T C172(0.96); C330(1.03); C307(1.10); C196(0.94)  LDD1638  [20]
 LDCM0435  CL45 HEK-293T C172(0.93); C330(0.92); C153(1.26); C307(1.17)  LDD1639  [20]
 LDCM0436  CL46 PaTu 8988t C330(1.01)  LDD1315  [12]
 LDCM0437  CL47 PaTu 8988t C330(1.03)  LDD1316  [12]
 LDCM0438  CL48 PaTu 8988t C330(0.86)  LDD1317  [12]
 LDCM0439  CL49 PaTu 8988t C330(1.21)  LDD1318  [12]
 LDCM0440  CL5 HCT 116 C330(0.76)  LDD0757  [12]
 LDCM0441  CL50 PaTu 8988t C330(0.93)  LDD1320  [12]
 LDCM0442  CL51 PaTu 8988t C330(0.88)  LDD1321  [12]
 LDCM0443  CL52 PaTu 8988t C330(0.72)  LDD1322  [12]
 LDCM0444  CL53 PaTu 8988t C330(0.71)  LDD1323  [12]
 LDCM0445  CL54 PaTu 8988t C330(2.10)  LDD1324  [12]
 LDCM0446  CL55 PaTu 8988t C330(1.29)  LDD1325  [12]
 LDCM0447  CL56 PaTu 8988t C330(0.20)  LDD1326  [12]
 LDCM0448  CL57 PaTu 8988t C330(0.27)  LDD1327  [12]
 LDCM0449  CL58 PaTu 8988t C330(0.47)  LDD1328  [12]
 LDCM0450  CL59 PaTu 8988t C330(0.24)  LDD1329  [12]
 LDCM0451  CL6 HCT 116 C330(0.84)  LDD0768  [12]
 LDCM0452  CL60 PaTu 8988t C330(0.28)  LDD1331  [12]
 LDCM0453  CL61 PaTu 8988t C330(1.02)  LDD1332  [12]
 LDCM0454  CL62 PaTu 8988t C330(1.05)  LDD1333  [12]
 LDCM0455  CL63 PaTu 8988t C330(1.31)  LDD1334  [12]
 LDCM0456  CL64 PaTu 8988t C330(0.94)  LDD1335  [12]
 LDCM0457  CL65 PaTu 8988t C330(0.61)  LDD1336  [12]
 LDCM0458  CL66 PaTu 8988t C330(1.03)  LDD1337  [12]
 LDCM0459  CL67 PaTu 8988t C330(0.38)  LDD1338  [12]
 LDCM0460  CL68 PaTu 8988t C330(0.36)  LDD1339  [12]
 LDCM0461  CL69 PaTu 8988t C330(0.36)  LDD1340  [12]
 LDCM0462  CL7 HCT 116 C330(0.71)  LDD0779  [12]
 LDCM0463  CL70 PaTu 8988t C330(0.34)  LDD1342  [12]
 LDCM0464  CL71 PaTu 8988t C330(1.10)  LDD1343  [12]
 LDCM0465  CL72 PaTu 8988t C330(1.79)  LDD1344  [12]
 LDCM0466  CL73 PaTu 8988t C330(0.42)  LDD1345  [12]
 LDCM0467  CL74 PaTu 8988t C330(2.14)  LDD1346  [12]
 LDCM0469  CL76 HEK-293T C172(1.05); C330(1.03); C153(0.88); C307(0.93)  LDD1672  [20]
 LDCM0470  CL77 HEK-293T C172(0.86); C330(0.90); C307(1.28)  LDD1673  [20]
 LDCM0471  CL78 HEK-293T C172(1.02); C330(0.93); C153(0.79); C307(0.99)  LDD1674  [20]
 LDCM0472  CL79 HEK-293T C172(0.92); C330(0.96); C153(0.92); C307(0.95)  LDD1675  [20]
 LDCM0473  CL8 HCT 116 C330(0.45)  LDD0790  [12]
 LDCM0474  CL80 HEK-293T C172(0.93); C330(1.05); C307(1.29); C196(0.95)  LDD1677  [20]
 LDCM0475  CL81 HEK-293T C172(0.88); C330(0.90); C153(1.28); C307(1.08)  LDD1678  [20]
 LDCM0476  CL82 HEK-293T C330(0.93); C153(0.89); C307(1.04); C196(0.72)  LDD1679  [20]
 LDCM0477  CL83 HEK-293T C330(0.91); C153(1.04); C307(1.01); C196(1.02)  LDD1680  [20]
 LDCM0478  CL84 HEK-293T C330(1.01); C153(1.30); C307(0.99); C196(0.74)  LDD1681  [20]
 LDCM0479  CL85 HEK-293T C172(1.00); C330(0.95); C153(0.91); C196(0.94)  LDD1682  [20]
 LDCM0480  CL86 HEK-293T C330(0.99); C153(0.85); C196(0.86)  LDD1683  [20]
 LDCM0481  CL87 HEK-293T C172(0.85); C330(0.86); C153(0.97); C307(0.79)  LDD1684  [20]
 LDCM0482  CL88 HEK-293T C172(1.08); C330(0.96); C153(0.74); C307(1.44)  LDD1685  [20]
 LDCM0483  CL89 HEK-293T C172(0.96); C330(0.96); C307(1.11)  LDD1686  [20]
 LDCM0484  CL9 HCT 116 C330(0.99)  LDD0801  [12]
 LDCM0485  CL90 HEK-293T C172(0.93); C330(0.89); C153(0.89); C307(0.91)  LDD1688  [20]
 LDCM0486  CL91 PaTu 8988t C330(0.46)  LDD1365  [12]
 LDCM0487  CL92 PaTu 8988t C330(0.35)  LDD1366  [12]
 LDCM0488  CL93 PaTu 8988t C330(0.45)  LDD1367  [12]
 LDCM0489  CL94 PaTu 8988t C330(0.58)  LDD1368  [12]
 LDCM0490  CL95 PaTu 8988t C330(0.38)  LDD1369  [12]
 LDCM0491  CL96 PaTu 8988t C330(0.60)  LDD1370  [12]
 LDCM0492  CL97 PaTu 8988t C330(0.62)  LDD1371  [12]
 LDCM0493  CL98 PaTu 8988t C330(0.36)  LDD1372  [12]
 LDCM0494  CL99 PaTu 8988t C330(0.40)  LDD1373  [12]
 LDCM0495  E2913 HEK-293T C172(0.94); C330(0.90); C153(1.11); C307(0.85)  LDD1698  [20]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [8]
 LDCM0573  Fragment11 Ramos C172(5.37)  LDD2190  [21]
 LDCM0576  Fragment14 Ramos C172(1.14)  LDD2193  [21]
 LDCM0586  Fragment28 Ramos C172(1.09)  LDD2198  [21]
 LDCM0468  Fragment33 PaTu 8988t C330(0.59)  LDD1347  [12]
 LDCM0427  Fragment51 HEK-293T C330(1.04); C153(0.99); C196(0.96)  LDD1631  [20]
 LDCM0116  HHS-0101 DM93 Y211(1.20)  LDD0264  [10]
 LDCM0117  HHS-0201 DM93 Y211(0.97)  LDD0265  [10]
 LDCM0118  HHS-0301 DM93 Y211(2.22)  LDD0266  [10]
 LDCM0119  HHS-0401 DM93 Y211(2.36)  LDD0267  [10]
 LDCM0120  HHS-0701 DM93 Y211(2.47)  LDD0268  [10]
 LDCM0107  IAA HeLa N.A.  LDD0221  [11]
 LDCM0123  JWB131 DM93 Y211(1.21)  LDD0285  [9]
 LDCM0124  JWB142 DM93 Y211(0.75)  LDD0286  [9]
 LDCM0125  JWB146 DM93 Y211(1.13)  LDD0287  [9]
 LDCM0126  JWB150 DM93 Y211(16.81)  LDD0288  [9]
 LDCM0127  JWB152 DM93 Y211(3.00)  LDD0289  [9]
 LDCM0128  JWB198 DM93 Y211(4.94)  LDD0290  [9]
 LDCM0129  JWB202 DM93 Y211(1.23)  LDD0291  [9]
 LDCM0130  JWB211 DM93 Y211(1.74)  LDD0292  [9]
 LDCM0022  KB02 HCT 116 C330(1.16)  LDD0080  [12]
 LDCM0023  KB03 HCT 116 C330(1.49)  LDD0081  [12]
 LDCM0024  KB05 HCT 116 C330(1.26)  LDD0082  [12]
 LDCM0109  NEM HeLa N.A.  LDD0233  [11]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C264(0.73)  LDD2127  [6]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C264(0.15)  LDD2128  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C262(0.44)  LDD2135  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C264(0.69)  LDD2137  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C264(0.88)  LDD2143  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
UDP-glucose 4-epimerase (GALE) NAD(P)-dependent epimerase/dehydratase family Q14376

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 14 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Galactose-uridine-5'-diphosphate Small molecular drug DB03501
Nicotinamide-adenine-dinucleotide Small molecular drug D0R6JE
Phenyl-uridine-5'-diphosphate Small molecular drug D05PNI
Psammaplin A Small molecular drug D0N0TS
Tetramethylammonium Small molecular drug DB03095
Tetramethylammonium Ion Small molecular drug D0T9SK
Udp-alpha-d-glucuronic Acid Small molecular drug DB03041
Udp-glucose Small molecular drug D07MIE
Uridine Diphosphate Galactose Small molecular drug D0K7WW
Uridine Diphosphate Glucose Small molecular drug DB01861
Uridine-5'-diphosphate Small molecular drug D02HAL
Uridine-5'-diphosphate-mannose Small molecular drug D0Z9JO
Uridine-diphosphate-n-acetylgalactosamine Small molecular drug D06UGK
Uridine-diphosphate-n-acetylglucosamine Small molecular drug D0KC2Z

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
9 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
10 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
11 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
12 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
15 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
16 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
17 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
18 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
19 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
20 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
21 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578