Details of the Target

General Information of Target

Target ID LDTP11331
Target Name Sideroflexin-3 (SFXN3)
Gene Name SFXN3
Gene ID 81855
Synonyms
Sideroflexin-3
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MASGSNWLSGVNVVLVMAYGSLVFVLLFIFVKRQIMRFAMKSRRGPHVPVGHNAPKDLKE
EIDIRLSRVQDIKYEPQLLADDDARLLQLETQGNQSCYNYLYRMKALDAIRTSEIPFHSE
GRHPRSLMGKNFRSYLLDLRNTSTPFKGVRKALIDTLLDGYETARYGTGVFGQNEYLRYQ
EALSELATAVKARIGSSQRHHQSAAKDLTQSPEVSPTTIQVTYLPSSQKSKRAKHFLELK
SFKDNYNTLESTL
Target Bioclass
Other
Family
Sideroflexin family
Subcellular location
Mitochondrion membrane
Function
Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway. Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors.
Uniprot ID
Q9BWM7
Ensemble ID
ENST00000393459.6
HGNC ID
HGNC:16087

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		10.41  LDD0402  [1]
STPyne
 Probe Info  		K169(4.51); K319(10.00); K71(7.49); K85(5.00)  LDD0277  [2]
DBIA
 Probe Info  		C234(2.11)  LDD3310  [3]
EA-probe
 Probe Info  		N.A.  LDD0440  [4]
Acrolein
 Probe Info  		H26(0.00); H293(0.00)  LDD0223  [5]
5E-2FA
 Probe Info  		N.A.  LDD2235  [6]
IA-alkyne
 Probe Info  		C234(0.00); C189(0.00)  LDD0162  [7]
TFBX
 Probe Info  		C234(0.00); C189(0.00)  LDD0027  [8]
IPM
 Probe Info  		N.A.  LDD2156  [9]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [5]
AOyne
 Probe Info  		12.70  LDD0443  [10]
NAIA_5
 Probe Info  		N.A.  LDD2223  [11]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0137  [12]
STS-2
 Probe Info  		N.A.  LDD0138  [12]
Staurosporine capture compound
 Probe Info  		N.A.  LDD0083  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0561  Abegg_cp(-)-10 HeLa C189(4.80)  LDD0312  [8]
 LDCM0214  AC1 PaTu 8988t C109(0.28)  LDD1093  [14]
 LDCM0215  AC10 PaTu 8988t C109(0.67); C193(0.53)  LDD1094  [14]
 LDCM0226  AC11 PaTu 8988t C109(0.84); C193(0.81)  LDD1105  [14]
 LDCM0237  AC12 PaTu 8988t C109(0.66); C193(0.71)  LDD1116  [14]
 LDCM0246  AC128 PaTu 8988t C193(0.94)  LDD1125  [14]
 LDCM0247  AC129 PaTu 8988t C193(1.26)  LDD1126  [14]
 LDCM0249  AC130 PaTu 8988t C193(1.21)  LDD1128  [14]
 LDCM0250  AC131 PaTu 8988t C193(1.22)  LDD1129  [14]
 LDCM0251  AC132 PaTu 8988t C193(0.66)  LDD1130  [14]
 LDCM0252  AC133 PaTu 8988t C193(0.63)  LDD1131  [14]
 LDCM0253  AC134 PaTu 8988t C193(0.87)  LDD1132  [14]
 LDCM0254  AC135 PaTu 8988t C193(0.89)  LDD1133  [14]
 LDCM0255  AC136 PaTu 8988t C193(0.62)  LDD1134  [14]
 LDCM0256  AC137 PaTu 8988t C193(0.70)  LDD1135  [14]
 LDCM0257  AC138 PaTu 8988t C193(1.16)  LDD1136  [14]
 LDCM0258  AC139 PaTu 8988t C193(0.88)  LDD1137  [14]
 LDCM0259  AC14 PaTu 8988t C109(0.88); C193(0.73)  LDD1138  [14]
 LDCM0260  AC140 PaTu 8988t C193(0.91)  LDD1139  [14]
 LDCM0261  AC141 PaTu 8988t C193(1.38)  LDD1140  [14]
 LDCM0262  AC142 PaTu 8988t C193(1.15)  LDD1141  [14]
 LDCM0263  AC143 PaTu 8988t C109(0.67); C193(0.70)  LDD1142  [14]
 LDCM0264  AC144 PaTu 8988t C109(0.58); C193(0.54)  LDD1143  [14]
 LDCM0265  AC145 PaTu 8988t C109(0.79); C193(0.61)  LDD1144  [14]
 LDCM0266  AC146 PaTu 8988t C109(0.35); C193(0.76)  LDD1145  [14]
 LDCM0267  AC147 PaTu 8988t C109(0.63); C193(0.85)  LDD1146  [14]
 LDCM0268  AC148 PaTu 8988t C109(0.49); C193(0.52)  LDD1147  [14]
 LDCM0269  AC149 PaTu 8988t C109(0.50); C193(0.49)  LDD1148  [14]
 LDCM0270  AC15 PaTu 8988t C109(0.62); C193(0.65)  LDD1149  [14]
 LDCM0271  AC150 PaTu 8988t C109(0.60); C193(0.82)  LDD1150  [14]
 LDCM0272  AC151 PaTu 8988t C109(0.60); C193(0.64)  LDD1151  [14]
 LDCM0273  AC152 PaTu 8988t C109(0.50); C193(0.55)  LDD1152  [14]
 LDCM0274  AC153 PaTu 8988t C109(0.56); C193(0.47)  LDD1153  [14]
 LDCM0621  AC154 PaTu 8988t C109(0.50); C193(0.53)  LDD2166  [14]
 LDCM0622  AC155 PaTu 8988t C109(0.53); C193(0.55)  LDD2167  [14]
 LDCM0623  AC156 PaTu 8988t C109(0.35); C193(0.56)  LDD2168  [14]
 LDCM0624  AC157 PaTu 8988t C109(0.53); C193(0.68)  LDD2169  [14]
 LDCM0279  AC2 PaTu 8988t C109(0.24)  LDD1158  [14]
 LDCM0285  AC25 PaTu 8988t C109(0.96); C193(0.98)  LDD1164  [14]
 LDCM0286  AC26 PaTu 8988t C109(0.66); C193(0.74)  LDD1165  [14]
 LDCM0287  AC27 PaTu 8988t C109(0.62); C193(0.70)  LDD1166  [14]
 LDCM0288  AC28 PaTu 8988t C109(0.67); C193(0.60)  LDD1167  [14]
 LDCM0289  AC29 PaTu 8988t C109(0.60); C193(0.60)  LDD1168  [14]
 LDCM0290  AC3 PaTu 8988t C109(0.23)  LDD1169  [14]
 LDCM0291  AC30 PaTu 8988t C109(1.24); C193(1.03)  LDD1170  [14]
 LDCM0292  AC31 PaTu 8988t C109(1.40); C193(0.99)  LDD1171  [14]
 LDCM0293  AC32 PaTu 8988t C109(1.19); C193(1.00)  LDD1172  [14]
 LDCM0294  AC33 PaTu 8988t C109(0.75); C193(0.67)  LDD1173  [14]
 LDCM0295  AC34 PaTu 8988t C109(0.95); C193(1.06)  LDD1174  [14]
 LDCM0296  AC35 PaTu 8988t C109(1.24); C193(0.55)  LDD1175  [14]
 LDCM0297  AC36 PaTu 8988t C109(1.02); C193(0.45)  LDD1176  [14]
 LDCM0298  AC37 PaTu 8988t C109(0.68); C193(0.76)  LDD1177  [14]
 LDCM0299  AC38 PaTu 8988t C109(0.74); C193(0.63)  LDD1178  [14]
 LDCM0300  AC39 PaTu 8988t C109(0.84); C193(0.56)  LDD1179  [14]
 LDCM0301  AC4 PaTu 8988t C109(0.26)  LDD1180  [14]
 LDCM0302  AC40 PaTu 8988t C109(0.73); C193(0.60)  LDD1181  [14]
 LDCM0303  AC41 PaTu 8988t C109(0.79); C193(0.74)  LDD1182  [14]
 LDCM0304  AC42 PaTu 8988t C109(0.55); C193(0.73)  LDD1183  [14]
 LDCM0305  AC43 PaTu 8988t C109(0.98); C193(0.76)  LDD1184  [14]
 LDCM0306  AC44 PaTu 8988t C109(0.59); C193(0.67)  LDD1185  [14]
 LDCM0307  AC45 PaTu 8988t C109(0.51); C193(0.83)  LDD1186  [14]
 LDCM0308  AC46 PaTu 8988t C109(1.00)  LDD1187  [14]
 LDCM0309  AC47 PaTu 8988t C109(0.84)  LDD1188  [14]
 LDCM0310  AC48 PaTu 8988t C109(0.74)  LDD1189  [14]
 LDCM0311  AC49 PaTu 8988t C109(0.98)  LDD1190  [14]
 LDCM0312  AC5 PaTu 8988t C109(0.26)  LDD1191  [14]
 LDCM0313  AC50 PaTu 8988t C109(0.80)  LDD1192  [14]
 LDCM0314  AC51 PaTu 8988t C109(0.93)  LDD1193  [14]
 LDCM0315  AC52 PaTu 8988t C109(0.94)  LDD1194  [14]
 LDCM0316  AC53 PaTu 8988t C109(0.82)  LDD1195  [14]
 LDCM0317  AC54 PaTu 8988t C109(0.89)  LDD1196  [14]
 LDCM0318  AC55 PaTu 8988t C109(0.96)  LDD1197  [14]
 LDCM0319  AC56 PaTu 8988t C109(0.86)  LDD1198  [14]
 LDCM0320  AC57 PaTu 8988t C109(1.04); C193(1.02)  LDD1199  [14]
 LDCM0321  AC58 PaTu 8988t C109(1.07); C193(0.94)  LDD1200  [14]
 LDCM0322  AC59 PaTu 8988t C109(1.29); C193(1.14)  LDD1201  [14]
 LDCM0323  AC6 PaTu 8988t C109(0.78); C193(0.58)  LDD1202  [14]
 LDCM0324  AC60 PaTu 8988t C109(1.16); C193(1.00)  LDD1203  [14]
 LDCM0325  AC61 PaTu 8988t C109(1.20); C193(0.98)  LDD1204  [14]
 LDCM0326  AC62 PaTu 8988t C109(1.16); C193(0.98)  LDD1205  [14]
 LDCM0327  AC63 PaTu 8988t C109(1.06); C193(0.88)  LDD1206  [14]
 LDCM0328  AC64 PaTu 8988t C109(1.01); C193(1.04)  LDD1207  [14]
 LDCM0329  AC65 PaTu 8988t C109(1.32); C193(1.12)  LDD1208  [14]
 LDCM0330  AC66 PaTu 8988t C109(1.26); C193(0.95)  LDD1209  [14]
 LDCM0331  AC67 PaTu 8988t C109(1.08); C193(1.04)  LDD1210  [14]
 LDCM0332  AC68 PaTu 8988t C109(1.16); C193(1.22)  LDD1211  [14]
 LDCM0333  AC69 PaTu 8988t C109(0.78); C193(1.05)  LDD1212  [14]
 LDCM0334  AC7 PaTu 8988t C109(1.10); C193(0.77)  LDD1213  [14]
 LDCM0335  AC70 PaTu 8988t C109(1.13); C193(0.98)  LDD1214  [14]
 LDCM0336  AC71 PaTu 8988t C109(1.10); C193(0.83)  LDD1215  [14]
 LDCM0337  AC72 PaTu 8988t C109(0.90); C193(1.31)  LDD1216  [14]
 LDCM0338  AC73 PaTu 8988t C109(0.83); C193(1.23)  LDD1217  [14]
 LDCM0339  AC74 PaTu 8988t C109(0.75); C193(1.08)  LDD1218  [14]
 LDCM0340  AC75 PaTu 8988t C109(0.77); C193(0.80)  LDD1219  [14]
 LDCM0341  AC76 PaTu 8988t C109(1.00); C193(1.04)  LDD1220  [14]
 LDCM0342  AC77 PaTu 8988t C109(0.79); C193(0.78)  LDD1221  [14]
 LDCM0343  AC78 PaTu 8988t C109(1.10); C193(1.12)  LDD1222  [14]
 LDCM0344  AC79 PaTu 8988t C109(0.84); C193(0.70)  LDD1223  [14]
 LDCM0345  AC8 PaTu 8988t C109(0.71); C193(0.74)  LDD1224  [14]
 LDCM0346  AC80 PaTu 8988t C109(1.03); C193(0.93)  LDD1225  [14]
 LDCM0347  AC81 PaTu 8988t C109(1.02); C193(1.34)  LDD1226  [14]
 LDCM0348  AC82 PaTu 8988t C109(0.65); C193(1.10)  LDD1227  [14]
 LDCM0248  AKOS034007472 PaTu 8988t C109(0.63); C193(0.73)  LDD1127  [14]
 LDCM0356  AKOS034007680 PaTu 8988t C109(0.66); C193(0.59)  LDD1235  [14]
 LDCM0275  AKOS034007705 PaTu 8988t C109(0.56); C193(0.51)  LDD1154  [14]
 LDCM0367  CL1 PaTu 8988t C193(0.64)  LDD1246  [14]
 LDCM0368  CL10 PaTu 8988t C193(0.42)  LDD1247  [14]
 LDCM0369  CL100 PaTu 8988t C109(0.23)  LDD1248  [14]
 LDCM0370  CL101 PaTu 8988t C109(0.86); C193(0.90)  LDD1249  [14]
 LDCM0371  CL102 PaTu 8988t C109(0.84); C193(0.56)  LDD1250  [14]
 LDCM0372  CL103 PaTu 8988t C109(0.67); C193(0.54)  LDD1251  [14]
 LDCM0373  CL104 PaTu 8988t C109(0.78); C193(0.62)  LDD1252  [14]
 LDCM0379  CL11 PaTu 8988t C193(0.55)  LDD1258  [14]
 LDCM0382  CL112 PaTu 8988t C109(0.97); C193(0.84)  LDD1261  [14]
 LDCM0383  CL113 PaTu 8988t C109(1.02); C193(0.97)  LDD1262  [14]
 LDCM0384  CL114 PaTu 8988t C109(0.78); C193(0.84)  LDD1263  [14]
 LDCM0385  CL115 PaTu 8988t C109(0.77); C193(0.99)  LDD1264  [14]
 LDCM0386  CL116 PaTu 8988t C109(0.60); C193(0.77)  LDD1265  [14]
 LDCM0387  CL117 PaTu 8988t C109(0.62); C193(0.83)  LDD1266  [14]
 LDCM0388  CL118 PaTu 8988t C109(0.42); C193(1.03)  LDD1267  [14]
 LDCM0389  CL119 PaTu 8988t C109(0.59); C193(0.67)  LDD1268  [14]
 LDCM0390  CL12 PaTu 8988t C193(1.04)  LDD1269  [14]
 LDCM0391  CL120 PaTu 8988t C109(1.03); C193(0.51)  LDD1270  [14]
 LDCM0392  CL121 PaTu 8988t C109(0.78)  LDD1271  [14]
 LDCM0393  CL122 PaTu 8988t C109(1.20)  LDD1272  [14]
 LDCM0394  CL123 PaTu 8988t C109(0.82)  LDD1273  [14]
 LDCM0395  CL124 PaTu 8988t C109(0.88)  LDD1274  [14]
 LDCM0396  CL125 PaTu 8988t C109(1.21); C193(1.10)  LDD1275  [14]
 LDCM0397  CL126 PaTu 8988t C109(1.23); C193(1.19)  LDD1276  [14]
 LDCM0398  CL127 PaTu 8988t C109(1.20); C193(1.01)  LDD1277  [14]
 LDCM0399  CL128 PaTu 8988t C109(1.00); C193(1.03)  LDD1278  [14]
 LDCM0400  CL13 PaTu 8988t C193(0.53)  LDD1279  [14]
 LDCM0401  CL14 PaTu 8988t C193(1.22)  LDD1280  [14]
 LDCM0402  CL15 PaTu 8988t C193(0.56)  LDD1281  [14]
 LDCM0407  CL2 PaTu 8988t C193(0.87)  LDD1286  [14]
 LDCM0418  CL3 PaTu 8988t C193(0.51)  LDD1297  [14]
 LDCM0420  CL31 PaTu 8988t C193(0.53)  LDD1299  [14]
 LDCM0421  CL32 PaTu 8988t C193(0.33)  LDD1300  [14]
 LDCM0422  CL33 PaTu 8988t C193(0.46)  LDD1301  [14]
 LDCM0423  CL34 PaTu 8988t C193(0.33)  LDD1302  [14]
 LDCM0424  CL35 PaTu 8988t C193(0.48)  LDD1303  [14]
 LDCM0425  CL36 PaTu 8988t C193(0.53)  LDD1304  [14]
 LDCM0426  CL37 PaTu 8988t C193(0.24)  LDD1305  [14]
 LDCM0428  CL39 PaTu 8988t C193(0.48)  LDD1307  [14]
 LDCM0429  CL4 PaTu 8988t C193(0.72)  LDD1308  [14]
 LDCM0430  CL40 PaTu 8988t C193(0.96)  LDD1309  [14]
 LDCM0431  CL41 PaTu 8988t C193(0.33)  LDD1310  [14]
 LDCM0432  CL42 PaTu 8988t C193(0.48)  LDD1311  [14]
 LDCM0433  CL43 PaTu 8988t C193(0.33)  LDD1312  [14]
 LDCM0434  CL44 PaTu 8988t C193(0.42)  LDD1313  [14]
 LDCM0435  CL45 PaTu 8988t C193(0.64)  LDD1314  [14]
 LDCM0436  CL46 PaTu 8988t C109(1.11)  LDD1315  [14]
 LDCM0437  CL47 PaTu 8988t C109(0.86)  LDD1316  [14]
 LDCM0438  CL48 PaTu 8988t C109(0.84)  LDD1317  [14]
 LDCM0439  CL49 PaTu 8988t C109(0.92)  LDD1318  [14]
 LDCM0440  CL5 PaTu 8988t C193(0.64)  LDD1319  [14]
 LDCM0441  CL50 PaTu 8988t C109(0.83)  LDD1320  [14]
 LDCM0442  CL51 PaTu 8988t C109(0.73)  LDD1321  [14]
 LDCM0443  CL52 PaTu 8988t C109(0.94)  LDD1322  [14]
 LDCM0444  CL53 PaTu 8988t C109(0.60)  LDD1323  [14]
 LDCM0445  CL54 PaTu 8988t C109(1.00)  LDD1324  [14]
 LDCM0446  CL55 PaTu 8988t C109(0.97)  LDD1325  [14]
 LDCM0447  CL56 PaTu 8988t C109(0.98)  LDD1326  [14]
 LDCM0448  CL57 PaTu 8988t C109(0.82)  LDD1327  [14]
 LDCM0449  CL58 PaTu 8988t C109(0.80)  LDD1328  [14]
 LDCM0450  CL59 PaTu 8988t C109(1.16)  LDD1329  [14]
 LDCM0451  CL6 PaTu 8988t C193(0.93)  LDD1330  [14]
 LDCM0452  CL60 PaTu 8988t C109(1.09)  LDD1331  [14]
 LDCM0453  CL61 PaTu 8988t C193(1.51)  LDD1332  [14]
 LDCM0454  CL62 PaTu 8988t C193(1.60)  LDD1333  [14]
 LDCM0455  CL63 PaTu 8988t C193(0.82)  LDD1334  [14]
 LDCM0456  CL64 PaTu 8988t C193(0.70)  LDD1335  [14]
 LDCM0457  CL65 PaTu 8988t C193(0.96)  LDD1336  [14]
 LDCM0458  CL66 PaTu 8988t C193(0.59)  LDD1337  [14]
 LDCM0459  CL67 PaTu 8988t C193(0.78)  LDD1338  [14]
 LDCM0460  CL68 PaTu 8988t C193(1.02)  LDD1339  [14]
 LDCM0461  CL69 PaTu 8988t C193(0.76)  LDD1340  [14]
 LDCM0462  CL7 PaTu 8988t C193(0.63)  LDD1341  [14]
 LDCM0463  CL70 PaTu 8988t C193(0.68)  LDD1342  [14]
 LDCM0464  CL71 PaTu 8988t C193(1.09)  LDD1343  [14]
 LDCM0465  CL72 PaTu 8988t C193(0.73)  LDD1344  [14]
 LDCM0466  CL73 PaTu 8988t C193(0.80)  LDD1345  [14]
 LDCM0467  CL74 PaTu 8988t C193(0.86)  LDD1346  [14]
 LDCM0469  CL76 PaTu 8988t C193(0.70)  LDD1348  [14]
 LDCM0470  CL77 PaTu 8988t C193(0.63)  LDD1349  [14]
 LDCM0471  CL78 PaTu 8988t C193(0.48)  LDD1350  [14]
 LDCM0472  CL79 PaTu 8988t C193(0.51)  LDD1351  [14]
 LDCM0473  CL8 PaTu 8988t C193(0.37)  LDD1352  [14]
 LDCM0474  CL80 PaTu 8988t C193(0.44)  LDD1353  [14]
 LDCM0475  CL81 PaTu 8988t C193(0.48)  LDD1354  [14]
 LDCM0476  CL82 PaTu 8988t C193(0.23)  LDD1355  [14]
 LDCM0477  CL83 PaTu 8988t C193(0.31)  LDD1356  [14]
 LDCM0478  CL84 PaTu 8988t C193(0.90)  LDD1357  [14]
 LDCM0479  CL85 PaTu 8988t C193(0.84)  LDD1358  [14]
 LDCM0480  CL86 PaTu 8988t C193(0.54)  LDD1359  [14]
 LDCM0481  CL87 PaTu 8988t C193(0.70)  LDD1360  [14]
 LDCM0482  CL88 PaTu 8988t C193(0.60)  LDD1361  [14]
 LDCM0483  CL89 PaTu 8988t C193(1.10)  LDD1362  [14]
 LDCM0484  CL9 PaTu 8988t C193(0.82)  LDD1363  [14]
 LDCM0485  CL90 PaTu 8988t C193(0.62)  LDD1364  [14]
 LDCM0486  CL91 PaTu 8988t C109(0.27)  LDD1365  [14]
 LDCM0487  CL92 PaTu 8988t C109(0.39)  LDD1366  [14]
 LDCM0488  CL93 PaTu 8988t C109(0.21)  LDD1367  [14]
 LDCM0489  CL94 PaTu 8988t C109(0.49)  LDD1368  [14]
 LDCM0490  CL95 PaTu 8988t C109(0.22)  LDD1369  [14]
 LDCM0491  CL96 PaTu 8988t C109(0.31)  LDD1370  [14]
 LDCM0492  CL97 PaTu 8988t C109(0.25)  LDD1371  [14]
 LDCM0493  CL98 PaTu 8988t C109(0.29)  LDD1372  [14]
 LDCM0494  CL99 PaTu 8988t C109(0.56)  LDD1373  [14]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [4]
 LDCM0468  Fragment33 PaTu 8988t C193(0.76)  LDD1347  [14]
 LDCM0427  Fragment51 PaTu 8988t C193(0.51)  LDD1306  [14]
 LDCM0015  HNE MDA-MB-231 C234(1.03); C189(0.91)  LDD0346  [15]
 LDCM0022  KB02 22RV1 C190(2.13); C234(1.81)  LDD2243  [3]
 LDCM0023  KB03 22RV1 C190(3.75); C234(3.12)  LDD2660  [3]
 LDCM0024  KB05 COLO792 C234(2.11)  LDD3310  [3]
 LDCM0109  NEM HeLa H26(0.00); H293(0.00)  LDD0223  [5]
 LDCM0019  Staurosporine Hep-G2 N.A.  LDD0083  [13]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Palmitoyltransferase ZDHHC15 (ZDHHC15) DHHC palmitoyltransferase family Q96MV8
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) EBP family Q15125
17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13) Short-chain dehydrogenases/reductases (SDR) family Q7Z5P4
Estradiol 17-beta-dehydrogenase 11 (HSD17B11) Short-chain dehydrogenases/reductases (SDR) family Q8NBQ5
TLC domain-containing protein 4 (TLCD4) TLCD4 family Q96MV1
Transporter and channel
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endophilin-B1 (SH3GLB1) Endophilin family Q9Y371
Huntingtin (HTT) Huntingtin family P42858
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Sodium channel regulatory subunit beta-3 (SCN3B) Sodium channel auxiliary subunit SCN3B family Q9NY72
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8
Thioredoxin-related transmembrane protein 2 (TMX2) . Q9Y320
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Receptor expression-enhancing protein 4 (REEP4) DP1 family Q9H6H4
Leptin receptor overlapping transcript-like 1 (LEPROTL1) OB-RGRP/VPS55 family O95214
Reticulophagy regulator 3 (RETREG3) RETREG family Q86VR2
RUS family member 1 (RUSF1) RUS1 family Q96GQ5
Transmembrane protein 51 (TMEM51) . Q9NW97

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
13 Comprehensive identification of staurosporine-binding kinases in the hepatocyte cell line HepG2 using Capture Compound Mass Spectrometry (CCMS). J Proteome Res. 2010 Feb 5;9(2):806-17. doi: 10.1021/pr9007333.
14 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
15 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578