Details of the Target

General Information of Target

Target ID LDTP06163
Target Name Interleukin-13 receptor subunit alpha-2 (IL13RA2)
Gene Name IL13RA2
Gene ID 3598
Synonyms
IL13R; Interleukin-13 receptor subunit alpha-2; IL-13 receptor subunit alpha-2; IL-13R subunit alpha-2; IL-13R-alpha-2; IL-13RA2; Interleukin-13-binding protein; CD antigen CD213a2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAFVCLAIGCLYTFLISTTFGCTSSSDTEIKVNPPQDFEIVDPGYLGYLYLQWQPPLSLD
HFKECTVEYELKYRNIGSETWKTIITKNLHYKDGFDLNKGIEAKIHTLLPWQCTNGSEVQ
SSWAETTYWISPQGIPETKVQDMDCVYYNWQYLLCSWKPGIGVLLDTNYNLFYWYEGLDH
ALQCVDYIKADGQNIGCRFPYLEASDYKDFYICVNGSSENKPIRSSYFTFQLQNIVKPLP
PVYLTFTRESSCEIKLKWSIPLGPIPARCFDYEIEIREDDTTLVTATVENETYTLKTTNE
TRQLCFVVRSKVNIYCSDDGIWSEWSDKQCWEGEDLSKKTLLRFWLPFGFILILVIFVTG
LLLRKPNTYPKMIPEFFCDT
Target Type
Clinical trial
Target Bioclass
Cytokine and receptor
Family
Type I cytokine receptor family, Type 5 subfamily
Subcellular location
Membrane
Function Binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4).
TTD ID
T40459
Uniprot ID
Q14627
DrugMap ID
TTMPZ7V
Ensemble ID
ENST00000243213.2
HGNC ID
HGNC:5975
ChEMBL ID
CHEMBL3713941

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		8.44  LDD0402  [1]
DBIA
 Probe Info  		C197(6.02); C65(2.21); C378(2.29)  LDD3327  [2]
EA-probe
 Probe Info  		N.A.  LDD0440  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [3]
 LDCM0022  KB02 A101D C252(0.99)  LDD2250  [2]
 LDCM0023  KB03 A-375 C197(4.92); C269(2.94); C252(1.80); C378(4.03)  LDD2672  [2]
 LDCM0024  KB05 WM115 C197(6.02); C65(2.21); C378(2.29)  LDD3327  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Chitinase-3-like protein 1 (CHI3L1) Glycosyl hydrolase 18 family P36222
Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6 (PLPP6) PA-phosphatase related phosphoesterase family Q8IY26
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Galectin-3 (LGALS3) . P17931
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Interleukin-13 (IL13) IL-4/IL-13 family P35225
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Insulin-like growth factor-binding protein 3 receptor (TMEM219) . Q86XT9

The Drug(s) Related To This Target

Phase 3
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Tralokinumab Monoclonal antibody D0I1ZY
Ict-107 Vaccine D0M1RD
Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Abt-308 . D0N3WN
Phase 1
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Mb-101 . D0YN9Y
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Aer001 . DB05078

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.