Details of the Target

General Information of Target

Target ID LDTP00812
Target Name Protein sprouty homolog 2 (SPRY2)
Gene Name SPRY2
Gene ID 10253
Synonyms
Protein sprouty homolog 2; Spry-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEARAQSGNGSQPLLQTPRDGGRQRGEPDPRDALTQQVHVLSLDQIRAIRNTNEYTEGPT
VVPRPGLKPAPRPSTQHKHERLHGLPEHRQPPRLQHSQVHSSARAPLSRSISTVSSGSRS
STRTSTSSSSSEQRLLGSSFSSGPVADGIIRVQPKSELKPGELKPLSKEDLGLHAYRCED
CGKCKCKECTYPRPLPSDWICDKQCLCSAQNVIDYGTCVCCVKGLFYHCSNDDEDNCADN
PCSCSQSHCCTRWSAMGVMSLFLPCLWCYLPAKGCLKLCQGCYDRVNRPGCRCKNSNTVC
CKVPTVPPRNFEKPT
Target Bioclass
Other
Family
Sprouty family
Subcellular location
Cytoplasm, cytoskeleton
Function
Antagonist of fibroblast growth factor (FGF) pathways via inhibition of FGF-mediated phosphorylation of ERK1/2. Thereby acts as an antagonist of FGF-induced retinal lens fiber differentiation, may inhibit limb bud outgrowth and may negatively modulate respiratory organogenesis. Inhibits TGFB-induced epithelial-to-mesenchymal transition in retinal lens epithelial cells. Inhibits CBL/C-CBL-mediated EGFR ubiquitination.
Uniprot ID
O43597
Ensemble ID
ENST00000377102.5
HGNC ID
HGNC:11270

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
EA-probe
 Probe Info  		N.A.  LDD0440  [1]
DBIA
 Probe Info  		C300(4.43); C301(4.43)  LDD0080  [2]
IPM
 Probe Info  		N.A.  LDD0005  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C291(0.96); C301(0.94)  LDD1507  [4]
 LDCM0215  AC10 HEK-293T C291(1.03); C301(1.05)  LDD1508  [4]
 LDCM0226  AC11 HEK-293T C291(1.06); C301(1.13)  LDD1509  [4]
 LDCM0237  AC12 HEK-293T C291(1.12); C301(1.13)  LDD1510  [4]
 LDCM0259  AC14 HEK-293T C291(1.14); C301(1.22); C300(1.23)  LDD1512  [4]
 LDCM0270  AC15 HEK-293T C291(1.13); C201(1.18); C301(0.96)  LDD1513  [4]
 LDCM0276  AC17 HEK-293T C291(0.98); C301(1.03)  LDD1515  [4]
 LDCM0277  AC18 HEK-293T C291(1.08); C301(1.11)  LDD1516  [4]
 LDCM0278  AC19 HEK-293T C291(3.58); C301(0.91)  LDD1517  [4]
 LDCM0279  AC2 HEK-293T C291(1.09); C301(0.86)  LDD1518  [4]
 LDCM0280  AC20 HEK-293T C291(1.06); C301(1.11)  LDD1519  [4]
 LDCM0281  AC21 HEK-293T C291(1.03)  LDD1520  [4]
 LDCM0282  AC22 HEK-293T C291(1.08); C301(1.03); C300(0.96)  LDD1521  [4]
 LDCM0283  AC23 HEK-293T C291(1.07); C201(0.96); C301(1.28)  LDD1522  [4]
 LDCM0284  AC24 HEK-293T C291(1.01)  LDD1523  [4]
 LDCM0285  AC25 HEK-293T C291(1.04); C301(1.19)  LDD1524  [4]
 LDCM0286  AC26 HEK-293T C291(1.07); C301(1.00)  LDD1525  [4]
 LDCM0287  AC27 HEK-293T C291(1.01); C301(1.08)  LDD1526  [4]
 LDCM0288  AC28 HEK-293T C291(1.03); C301(0.91)  LDD1527  [4]
 LDCM0289  AC29 HEK-293T C291(1.02)  LDD1528  [4]
 LDCM0290  AC3 HEK-293T C291(0.99); C301(0.98)  LDD1529  [4]
 LDCM0291  AC30 HEK-293T C291(1.11); C301(0.97); C300(0.96)  LDD1530  [4]
 LDCM0292  AC31 HEK-293T C291(1.14); C201(0.95); C301(1.11)  LDD1531  [4]
 LDCM0293  AC32 HEK-293T C291(1.05)  LDD1532  [4]
 LDCM0294  AC33 HEK-293T C291(1.01); C301(1.14)  LDD1533  [4]
 LDCM0295  AC34 HEK-293T C291(1.05); C301(1.06)  LDD1534  [4]
 LDCM0296  AC35 HEK-293T C291(1.03); C301(1.14)  LDD1535  [4]
 LDCM0297  AC36 HEK-293T C291(1.11); C301(1.13)  LDD1536  [4]
 LDCM0298  AC37 HEK-293T C291(1.09)  LDD1537  [4]
 LDCM0299  AC38 HEK-293T C291(1.11); C301(0.95); C300(1.00)  LDD1538  [4]
 LDCM0300  AC39 HEK-293T C291(1.09); C201(1.35); C301(0.96)  LDD1539  [4]
 LDCM0301  AC4 HEK-293T C291(1.09); C301(1.02)  LDD1540  [4]
 LDCM0302  AC40 HEK-293T C291(1.05)  LDD1541  [4]
 LDCM0303  AC41 HEK-293T C291(0.99); C301(1.20)  LDD1542  [4]
 LDCM0304  AC42 HEK-293T C291(1.02); C301(1.10)  LDD1543  [4]
 LDCM0305  AC43 HEK-293T C291(1.13); C301(1.31)  LDD1544  [4]
 LDCM0306  AC44 HEK-293T C291(1.12); C301(0.99)  LDD1545  [4]
 LDCM0307  AC45 HEK-293T C291(1.07)  LDD1546  [4]
 LDCM0308  AC46 HEK-293T C291(1.08); C301(1.16); C300(1.17)  LDD1547  [4]
 LDCM0309  AC47 HEK-293T C291(1.12); C201(1.26); C301(0.83)  LDD1548  [4]
 LDCM0310  AC48 HEK-293T C291(1.07)  LDD1549  [4]
 LDCM0311  AC49 HEK-293T C291(1.00); C301(1.23)  LDD1550  [4]
 LDCM0312  AC5 HEK-293T C291(1.02)  LDD1551  [4]
 LDCM0313  AC50 HEK-293T C291(1.10); C301(1.07)  LDD1552  [4]
 LDCM0314  AC51 HEK-293T C291(1.06); C301(1.18)  LDD1553  [4]
 LDCM0315  AC52 HEK-293T C291(1.13); C301(1.03)  LDD1554  [4]
 LDCM0316  AC53 HEK-293T C291(0.97)  LDD1555  [4]
 LDCM0317  AC54 HEK-293T C291(1.09); C301(1.01); C300(1.29)  LDD1556  [4]
 LDCM0318  AC55 HEK-293T C291(1.10); C201(1.12); C301(1.15)  LDD1557  [4]
 LDCM0319  AC56 HEK-293T C291(1.05)  LDD1558  [4]
 LDCM0320  AC57 HEK-293T C291(1.05); C301(1.19)  LDD1559  [4]
 LDCM0321  AC58 HEK-293T C291(1.11); C301(0.90)  LDD1560  [4]
 LDCM0322  AC59 HEK-293T C291(1.09); C301(0.99)  LDD1561  [4]
 LDCM0323  AC6 HEK-293T C291(1.16); C301(0.91); C300(1.09)  LDD1562  [4]
 LDCM0324  AC60 HEK-293T C291(1.08); C301(1.02)  LDD1563  [4]
 LDCM0325  AC61 HEK-293T C291(1.03)  LDD1564  [4]
 LDCM0326  AC62 HEK-293T C291(1.06); C301(0.98); C300(1.05)  LDD1565  [4]
 LDCM0327  AC63 HEK-293T C291(1.14); C201(1.14); C301(0.79)  LDD1566  [4]
 LDCM0328  AC64 HEK-293T C291(1.06)  LDD1567  [4]
 LDCM0334  AC7 HEK-293T C291(1.02); C201(1.07); C301(0.90)  LDD1568  [4]
 LDCM0345  AC8 HEK-293T C291(1.02)  LDD1569  [4]
 LDCM0248  AKOS034007472 HEK-293T C291(0.97)  LDD1511  [4]
 LDCM0356  AKOS034007680 HEK-293T C291(1.00); C301(1.46)  LDD1570  [4]
 LDCM0275  AKOS034007705 HEK-293T C291(1.04)  LDD1514  [4]
 LDCM0367  CL1 HEK-293T C291(1.02)  LDD1571  [4]
 LDCM0368  CL10 HEK-293T C291(1.43); C301(1.09); C300(1.07)  LDD1572  [4]
 LDCM0369  CL100 HEK-293T C291(1.01)  LDD1573  [4]
 LDCM0370  CL101 HEK-293T C291(1.03)  LDD1574  [4]
 LDCM0371  CL102 HEK-293T C291(0.96); C300(1.20)  LDD1575  [4]
 LDCM0372  CL103 HEK-293T C300(1.18)  LDD1576  [4]
 LDCM0373  CL104 HEK-293T C291(1.02)  LDD1577  [4]
 LDCM0374  CL105 HEK-293T C291(1.00)  LDD1578  [4]
 LDCM0375  CL106 HEK-293T C291(0.97); C300(0.99)  LDD1579  [4]
 LDCM0376  CL107 HEK-293T C300(1.01)  LDD1580  [4]
 LDCM0377  CL108 HEK-293T C291(1.04)  LDD1581  [4]
 LDCM0378  CL109 HEK-293T C291(0.97)  LDD1582  [4]
 LDCM0379  CL11 HEK-293T C291(1.30); C201(1.58); C301(1.12)  LDD1583  [4]
 LDCM0380  CL110 HEK-293T C291(1.05); C300(0.94)  LDD1584  [4]
 LDCM0381  CL111 HEK-293T C300(1.14)  LDD1585  [4]
 LDCM0382  CL112 HEK-293T C291(1.02)  LDD1586  [4]
 LDCM0383  CL113 HEK-293T C291(0.98)  LDD1587  [4]
 LDCM0384  CL114 HEK-293T C291(1.03); C300(1.12)  LDD1588  [4]
 LDCM0385  CL115 HEK-293T C300(1.28)  LDD1589  [4]
 LDCM0386  CL116 HEK-293T C291(1.08)  LDD1590  [4]
 LDCM0387  CL117 HEK-293T C291(1.01)  LDD1591  [4]
 LDCM0388  CL118 HEK-293T C291(1.18); C300(1.13)  LDD1592  [4]
 LDCM0389  CL119 HEK-293T C300(1.07)  LDD1593  [4]
 LDCM0390  CL12 HEK-293T C291(1.35)  LDD1594  [4]
 LDCM0391  CL120 HEK-293T C291(1.00)  LDD1595  [4]
 LDCM0392  CL121 HEK-293T C291(0.99)  LDD1596  [4]
 LDCM0393  CL122 HEK-293T C291(1.07); C300(1.11)  LDD1597  [4]
 LDCM0394  CL123 HEK-293T C300(1.49)  LDD1598  [4]
 LDCM0395  CL124 HEK-293T C291(1.00)  LDD1599  [4]
 LDCM0396  CL125 HEK-293T C291(1.07)  LDD1600  [4]
 LDCM0397  CL126 HEK-293T C291(1.02); C300(1.22)  LDD1601  [4]
 LDCM0398  CL127 HEK-293T C300(1.10)  LDD1602  [4]
 LDCM0399  CL128 HEK-293T C291(1.16)  LDD1603  [4]
 LDCM0400  CL13 HEK-293T C291(0.97)  LDD1604  [4]
 LDCM0401  CL14 HEK-293T C291(0.87); C300(1.14)  LDD1605  [4]
 LDCM0402  CL15 HEK-293T C300(1.06)  LDD1606  [4]
 LDCM0403  CL16 HEK-293T C291(1.08)  LDD1607  [4]
 LDCM0404  CL17 HEK-293T C291(1.03); C301(1.19)  LDD1608  [4]
 LDCM0405  CL18 HEK-293T C291(1.07); C301(1.19)  LDD1609  [4]
 LDCM0406  CL19 HEK-293T C291(1.09); C301(1.09)  LDD1610  [4]
 LDCM0407  CL2 HEK-293T C291(1.05); C300(1.14)  LDD1611  [4]
 LDCM0408  CL20 HEK-293T C291(1.26); C301(1.16)  LDD1612  [4]
 LDCM0409  CL21 HEK-293T C291(1.18)  LDD1613  [4]
 LDCM0410  CL22 HEK-293T C291(1.29); C301(1.11); C300(0.94)  LDD1614  [4]
 LDCM0411  CL23 HEK-293T C291(1.28); C201(1.92); C301(1.23)  LDD1615  [4]
 LDCM0412  CL24 HEK-293T C291(1.29)  LDD1616  [4]
 LDCM0413  CL25 HEK-293T C291(1.09)  LDD1617  [4]
 LDCM0414  CL26 HEK-293T C291(1.00); C300(1.17)  LDD1618  [4]
 LDCM0415  CL27 HEK-293T C300(1.25)  LDD1619  [4]
 LDCM0416  CL28 HEK-293T C291(1.01)  LDD1620  [4]
 LDCM0417  CL29 HEK-293T C291(1.02); C301(1.25)  LDD1621  [4]
 LDCM0418  CL3 HEK-293T C300(0.93)  LDD1622  [4]
 LDCM0419  CL30 HEK-293T C291(1.04); C301(1.01)  LDD1623  [4]
 LDCM0420  CL31 HEK-293T C291(1.12); C301(1.14)  LDD1624  [4]
 LDCM0421  CL32 HEK-293T C291(1.13); C301(1.38)  LDD1625  [4]
 LDCM0422  CL33 HEK-293T C291(1.27)  LDD1626  [4]
 LDCM0423  CL34 HEK-293T C291(1.20); C301(1.10); C300(1.03)  LDD1627  [4]
 LDCM0424  CL35 HEK-293T C291(1.30); C201(1.30); C301(1.13)  LDD1628  [4]
 LDCM0425  CL36 HEK-293T C291(1.27)  LDD1629  [4]
 LDCM0426  CL37 HEK-293T C291(0.98)  LDD1630  [4]
 LDCM0428  CL39 HEK-293T C300(0.96)  LDD1632  [4]
 LDCM0429  CL4 HEK-293T C291(1.12)  LDD1633  [4]
 LDCM0430  CL40 HEK-293T C291(0.99)  LDD1634  [4]
 LDCM0431  CL41 HEK-293T C291(0.91); C301(1.47)  LDD1635  [4]
 LDCM0432  CL42 HEK-293T C291(1.14); C301(1.32)  LDD1636  [4]
 LDCM0433  CL43 HEK-293T C291(1.14); C301(1.14)  LDD1637  [4]
 LDCM0434  CL44 HEK-293T C291(1.18); C301(0.99)  LDD1638  [4]
 LDCM0435  CL45 HEK-293T C291(1.21)  LDD1639  [4]
 LDCM0436  CL46 HEK-293T C291(1.27); C301(0.97); C300(0.87)  LDD1640  [4]
 LDCM0437  CL47 HEK-293T C291(1.28); C201(1.37); C301(1.19)  LDD1641  [4]
 LDCM0438  CL48 HEK-293T C291(1.18)  LDD1642  [4]
 LDCM0439  CL49 HEK-293T C291(1.01)  LDD1643  [4]
 LDCM0440  CL5 HEK-293T C291(1.02); C301(1.17)  LDD1644  [4]
 LDCM0441  CL50 HEK-293T C291(1.12); C300(1.14)  LDD1645  [4]
 LDCM0443  CL52 HEK-293T C291(1.14)  LDD1646  [4]
 LDCM0444  CL53 HEK-293T C291(1.13); C301(1.36)  LDD1647  [4]
 LDCM0445  CL54 HEK-293T C291(1.14); C301(1.08)  LDD1648  [4]
 LDCM0446  CL55 HEK-293T C291(1.26); C301(1.11)  LDD1649  [4]
 LDCM0447  CL56 HEK-293T C291(1.29); C301(1.13)  LDD1650  [4]
 LDCM0448  CL57 HEK-293T C291(1.20)  LDD1651  [4]
 LDCM0449  CL58 HEK-293T C291(1.40); C301(1.23); C300(1.21)  LDD1652  [4]
 LDCM0450  CL59 HEK-293T C291(1.34); C201(1.23); C301(1.40)  LDD1653  [4]
 LDCM0451  CL6 HEK-293T C291(1.17); C301(1.01)  LDD1654  [4]
 LDCM0452  CL60 HEK-293T C291(1.45)  LDD1655  [4]
 LDCM0453  CL61 HEK-293T C291(1.09)  LDD1656  [4]
 LDCM0454  CL62 HEK-293T C291(1.09); C300(0.98)  LDD1657  [4]
 LDCM0455  CL63 HEK-293T C300(1.23)  LDD1658  [4]
 LDCM0456  CL64 HEK-293T C291(1.08)  LDD1659  [4]
 LDCM0457  CL65 HEK-293T C291(0.98); C301(1.19)  LDD1660  [4]
 LDCM0458  CL66 HEK-293T C291(1.07); C301(1.01)  LDD1661  [4]
 LDCM0459  CL67 HEK-293T C291(1.13); C301(1.12)  LDD1662  [4]
 LDCM0460  CL68 HEK-293T C291(1.15); C301(1.01)  LDD1663  [4]
 LDCM0461  CL69 HEK-293T C291(1.12)  LDD1664  [4]
 LDCM0462  CL7 HEK-293T C291(1.18); C301(1.12)  LDD1665  [4]
 LDCM0463  CL70 HEK-293T C291(1.22); C301(1.15); C300(1.09)  LDD1666  [4]
 LDCM0464  CL71 HEK-293T C291(1.35); C201(1.45); C301(1.02)  LDD1667  [4]
 LDCM0465  CL72 HEK-293T C291(1.22)  LDD1668  [4]
 LDCM0466  CL73 HEK-293T C291(0.98)  LDD1669  [4]
 LDCM0467  CL74 HEK-293T C291(1.00); C300(1.11)  LDD1670  [4]
 LDCM0469  CL76 HEK-293T C291(1.09)  LDD1672  [4]
 LDCM0470  CL77 HEK-293T C291(1.02); C301(1.37)  LDD1673  [4]
 LDCM0471  CL78 HEK-293T C291(1.05); C301(1.21)  LDD1674  [4]
 LDCM0472  CL79 HEK-293T C291(1.19); C301(1.23)  LDD1675  [4]
 LDCM0473  CL8 HEK-293T C291(1.27); C301(0.97)  LDD1676  [4]
 LDCM0474  CL80 HEK-293T C291(1.16); C301(0.92)  LDD1677  [4]
 LDCM0475  CL81 HEK-293T C291(1.05)  LDD1678  [4]
 LDCM0476  CL82 HEK-293T C291(1.21); C301(1.06); C300(1.07)  LDD1679  [4]
 LDCM0477  CL83 HEK-293T C291(1.23); C201(1.33); C301(1.10)  LDD1680  [4]
 LDCM0478  CL84 HEK-293T C291(1.18)  LDD1681  [4]
 LDCM0479  CL85 HEK-293T C291(1.09)  LDD1682  [4]
 LDCM0480  CL86 HEK-293T C291(1.05); C300(1.06)  LDD1683  [4]
 LDCM0481  CL87 HEK-293T C300(1.14)  LDD1684  [4]
 LDCM0482  CL88 HEK-293T C291(1.08)  LDD1685  [4]
 LDCM0483  CL89 HEK-293T C291(1.15); C301(1.17)  LDD1686  [4]
 LDCM0484  CL9 HEK-293T C291(1.15)  LDD1687  [4]
 LDCM0485  CL90 HEK-293T C291(1.33); C301(1.40)  LDD1688  [4]
 LDCM0486  CL91 HEK-293T C291(1.17); C301(1.16)  LDD1689  [4]
 LDCM0487  CL92 HEK-293T C291(1.20); C301(0.98)  LDD1690  [4]
 LDCM0488  CL93 HEK-293T C291(1.10)  LDD1691  [4]
 LDCM0489  CL94 HEK-293T C291(1.20); C301(1.22); C300(1.01)  LDD1692  [4]
 LDCM0490  CL95 HEK-293T C291(1.21); C201(0.92); C301(1.05)  LDD1693  [4]
 LDCM0491  CL96 HEK-293T C291(1.26)  LDD1694  [4]
 LDCM0492  CL97 HEK-293T C291(0.97)  LDD1695  [4]
 LDCM0493  CL98 HEK-293T C291(0.96); C300(1.00)  LDD1696  [4]
 LDCM0494  CL99 HEK-293T C300(1.16)  LDD1697  [4]
 LDCM0495  E2913 HEK-293T C300(1.13)  LDD1698  [4]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C300(5.21)  LDD1702  [5]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [1]
 LDCM0468  Fragment33 HEK-293T C300(1.08)  LDD1671  [4]
 LDCM0427  Fragment51 HEK-293T C291(1.10); C300(1.02)  LDD1631  [4]
 LDCM0022  KB02 HCT 116 C300(4.43); C301(4.43)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C300(2.37); C301(2.37)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C300(8.35); C301(8.35)  LDD0082  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
3 beta-hydroxysteroid dehydrogenase type 7 (HSD3B7) 3-beta-HSD family Q9H2F3
5'-AMP-activated protein kinase subunit beta-2 (PRKAB2) 5'-AMP-activated protein kinase beta subunit family O43741
Palmitoyltransferase ZDHHC17 (ZDHHC17) DHHC palmitoyltransferase family Q8IUH5
Ubiquitin carboxyl-terminal hydrolase 20 (USP20) Peptidase C19 family Q9Y2K6
Serine/threonine-protein kinase 16 (STK16) Ser/Thr protein kinase family O75716
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) UDP-N-acetylglucosamine 2-epimerase family; ROK (NagC/XylR) family Q9Y223
E3 ubiquitin-protein ligase CBL (CBL) . P22681
LON peptidase N-terminal domain and RING finger protein 1 (LONRF1) . Q17RB8
Ubiquitin-associated and SH3 domain-containing protein B (UBASH3B) . Q8TF42
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cation channel sperm-associated protein 1 (CATSPER1) Cation channel sperm-associated (TC 1.A.1.19) family Q8NEC5
MyoD family inhibitor (MDFI) MDFI family Q99750
Aquaporin-1 (AQP1) MIP/aquaporin (TC 1.A.8) family P29972
Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 417 (ZNF417) Krueppel C2H2-type zinc-finger protein family Q8TAU3
Zinc finger protein 587 (ZNF587) Krueppel C2H2-type zinc-finger protein family Q96SQ5
Homeobox protein OTX1 (OTX1) Paired homeobox family P32242
Homeobox protein MOX-2 (MEOX2) . P50222
Other
Click To Hide/Show 35 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ATR-interacting protein (ATRIP) ATRIP family Q8WXE1
Chordin (CHRD) Chordin family Q9H2X0
Eukaryotic translation initiation factor 4E type 2 (EIF4E2) Eukaryotic initiation factor 4E family O60573
Fas apoptotic inhibitory molecule 1 (FAIM) FAIM1 family Q9NVQ4
Progranulin (GRN) Granulin family P28799
GRB2-related adapter protein 2 (GRAP2) GRB2/sem-5/DRK family O75791
Growth factor receptor-bound protein 2 (GRB2) GRB2/sem-5/DRK family P62993
Protein HEXIM2 (HEXIM2) HEXIM family Q96MH2
Keratin-associated protein 10-11 (KRTAP10-11) KRTAP type 10 family P60412
Keratin-associated protein 10-5 (KRTAP10-5) KRTAP type 10 family P60370
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Keratin-associated protein 10-9 (KRTAP10-9) KRTAP type 10 family P60411
Keratin-associated protein 4-11 (KRTAP4-11) KRTAP type 4 family Q9BYQ6
Keratin-associated protein 4-12 (KRTAP4-12) KRTAP type 4 family Q9BQ66
Keratin-associated protein 4-7 (KRTAP4-7) KRTAP type 4 family Q9BYR0
Keratin-associated protein 5-6 (KRTAP5-6) KRTAP type 5 family Q6L8G9
Keratin-associated protein 5-9 (KRTAP5-9) KRTAP type 5 family P26371
Keratin-associated protein 9-2 (KRTAP9-2) KRTAP type 9 family Q9BYQ4
Keratin-associated protein 9-4 (KRTAP9-4) KRTAP type 9 family Q9BYQ2
Late cornified envelope protein 1B (LCE1B) LCE family Q5T7P3
Late cornified envelope protein 2D (LCE2D) LCE family Q5TA82
Late cornified envelope protein 3C (LCE3C) LCE family Q5T5A8
Late cornified envelope protein 3E (LCE3E) LCE family Q5T5B0
Late cornified envelope protein 4A (LCE4A) LCE family Q5TA78
Protein kinase C and casein kinase substrate in neurons protein 3 (PACSIN3) PACSIN family Q9UKS6
Shiftless antiviral inhibitor of ribosomal frameshifting protein (SHFL) SHFL family Q9NUL5
Protein sprouty homolog 1 (SPRY1) Sprouty family O43609
TRPM8 channel-associated factor 1 (TCAF1) TCAF family Q9Y4C2
Cytoplasmic protein NCK2 (NCK2) . O43639
Fibroblast growth factor receptor substrate 3 (FRS3) . O43559
LIM and SH3 domain protein 1 (LASP1) . Q14847
Mitogen-activated protein kinase-binding protein 1 (MAPKBP1) . O60336
Platelet glycoprotein IX (GP9) . P14770
SH3 domain-containing kinase-binding protein 1 (SH3KBP1) . Q96B97
Ubiquitin-associated and SH3 domain-containing protein A (UBASH3A) . P57075

References

1 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761