Details of the Target

General Information of Target

Target ID LDTP09779
Target Name Proteasome inhibitor PI31 subunit (PSMF1)
Gene Name PSMF1
Gene ID 9491
Synonyms
Proteasome inhibitor PI31 subunit; hPI31
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLPRTKYNRFRNDSVTSVDDLLHSLSVSGGGGKVSAARATPAAAPYLVSGEALRKAPDDG
PGSLGHLLHKVSHLKLSSSGLRGLSSAARERAGARLSGSCSAPSLAAPDGSAPSAPRAPA
MSAARKGRPGDEPLPRPPRGAPHASDQVLGPGVTYVVKYLGCIEVLRSMRSLDFSTRTQI
TREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGKSNLQFAGMSISLTISTASLNLRTPD
SKQIIANHHMRSISFASGGDPDTTDYVAYVAKDPVNRRACHILECCDGLAQDVIGSIGQA
FELRFKQYLQCPTKIPALHDRMQSLDEPWTEEEGDGSDHPYYNSIPSKMPPPGGFLDTRL
KPRPHAPDTAQFAGKEQTYYQGRHLGDTFGEDWQQTPLRQGSSDIYSTPEGKLHVAPTGE
APTYVNTQQIPPQAWPAAVSSAESSPRKDLFDMKPFEDALKNQPLGPVLSKAASVECISP
VSPRAPDAKMLEELQAETWYQGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQ
AKHLLLVDPEGTIRTKDRVFDSISHLINHHLESSLPIVSAGSELCLQQPVERKQ
Target Bioclass
Other
Family
Proteasome inhibitor PI31 family
Subcellular location
Cytoplasm
Function
Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.
Uniprot ID
Q92530
Ensemble ID
ENST00000333082.7
HGNC ID
HGNC:9571

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
YN-4
 Probe Info  		100.00  LDD0445  [2]
ONAyne
 Probe Info  		K72(9.09)  LDD0275  [3]
AHL-Pu-1
 Probe Info  		C185(2.53)  LDD0169  [4]
EA-probe
 Probe Info  		N.A.  LDD0440  [5]
DBIA
 Probe Info  		C185(0.93)  LDD0547  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [8]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [7]
NAIA_4
 Probe Info  		N.A.  LDD2226  [9]
IPM
 Probe Info  		N.A.  LDD2156  [10]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [11]
1c-yne
 Probe Info  		N.A.  LDD0228  [12]
AOyne
 Probe Info  		12.20  LDD0443  [13]
NAIA_5
 Probe Info  		N.A.  LDD2223  [9]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C403
 Probe Info  		17.51  LDD2061  [14]
FFF probe2
 Probe Info  		20.00  LDD0463  [15]
FFF probe3
 Probe Info  		20.00  LDD0464  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C185(2.53)  LDD0169  [4]
 LDCM0214  AC1 HEK-293T C185(0.93)  LDD0812  [6]
 LDCM0215  AC10 HEK-293T C185(1.09)  LDD0813  [6]
 LDCM0216  AC100 PaTu 8988t C185(1.25)  LDD1095  [6]
 LDCM0217  AC101 PaTu 8988t C185(1.04)  LDD1096  [6]
 LDCM0218  AC102 PaTu 8988t C185(1.04)  LDD1097  [6]
 LDCM0219  AC103 PaTu 8988t C185(1.21)  LDD1098  [6]
 LDCM0220  AC104 PaTu 8988t C185(1.02)  LDD1099  [6]
 LDCM0221  AC105 PaTu 8988t C185(1.30)  LDD1100  [6]
 LDCM0222  AC106 PaTu 8988t C185(1.50)  LDD1101  [6]
 LDCM0223  AC107 PaTu 8988t C185(1.28)  LDD1102  [6]
 LDCM0224  AC108 PaTu 8988t C185(1.24)  LDD1103  [6]
 LDCM0225  AC109 PaTu 8988t C185(1.32)  LDD1104  [6]
 LDCM0226  AC11 HEK-293T C185(0.99)  LDD0824  [6]
 LDCM0227  AC110 PaTu 8988t C185(1.76)  LDD1106  [6]
 LDCM0228  AC111 PaTu 8988t C185(1.52)  LDD1107  [6]
 LDCM0229  AC112 PaTu 8988t C185(1.25)  LDD1108  [6]
 LDCM0230  AC113 HCT 116 C185(0.93)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C185(1.00)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C185(1.32)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C185(1.53)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C185(1.09)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C185(1.08)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C185(1.09)  LDD0553  [6]
 LDCM0237  AC12 HEK-293T C185(1.06)  LDD0835  [6]
 LDCM0238  AC120 HCT 116 C185(1.34)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C185(1.05)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C185(0.93)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C185(1.05)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C185(1.00)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C185(1.05)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C185(1.28)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C185(1.37)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C185(1.47)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C185(1.32)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C185(1.16)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C185(0.93)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C185(0.77)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C185(0.86)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C185(1.03)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C185(0.98)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C185(0.99)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C185(0.96)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C185(1.03)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C185(1.01)  LDD0575  [6]
 LDCM0259  AC14 HEK-293T C185(1.25)  LDD0857  [6]
 LDCM0260  AC140 HCT 116 C185(1.10)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C185(0.80)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C185(0.87)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C185(0.97)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C185(1.30)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C185(1.21)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C185(1.32)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C185(1.52)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C185(1.84)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C185(1.55)  LDD0586  [6]
 LDCM0270  AC15 HEK-293T C185(1.13)  LDD0868  [6]
 LDCM0271  AC150 HCT 116 C185(1.13)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C185(1.21)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C185(1.32)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C185(2.06)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C185(1.36)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C185(1.33)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C185(0.95)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C185(1.16)  LDD2161  [6]
 LDCM0276  AC17 PaTu 8988t C185(1.17)  LDD1155  [6]
 LDCM0277  AC18 PaTu 8988t C185(1.22)  LDD1156  [6]
 LDCM0278  AC19 PaTu 8988t C185(1.11)  LDD1157  [6]
 LDCM0279  AC2 HEK-293T C185(0.99)  LDD0877  [6]
 LDCM0280  AC20 PaTu 8988t C185(1.09)  LDD1159  [6]
 LDCM0281  AC21 PaTu 8988t C185(1.35)  LDD1160  [6]
 LDCM0282  AC22 PaTu 8988t C185(1.33)  LDD1161  [6]
 LDCM0283  AC23 PaTu 8988t C185(1.73)  LDD1162  [6]
 LDCM0284  AC24 PaTu 8988t C185(1.12)  LDD1163  [6]
 LDCM0285  AC25 HEK-293T C185(1.07)  LDD1524  [16]
 LDCM0286  AC26 HEK-293T C185(0.80)  LDD1525  [16]
 LDCM0287  AC27 HEK-293T C185(1.01)  LDD1526  [16]
 LDCM0288  AC28 HEK-293T C185(0.97)  LDD1527  [16]
 LDCM0289  AC29 HEK-293T C185(1.04)  LDD1528  [16]
 LDCM0290  AC3 HEK-293T C185(1.01)  LDD0888  [6]
 LDCM0291  AC30 HEK-293T C185(0.90)  LDD1530  [16]
 LDCM0292  AC31 HEK-293T C185(0.94)  LDD1531  [16]
 LDCM0293  AC32 HEK-293T C185(1.03)  LDD1532  [16]
 LDCM0294  AC33 HEK-293T C185(1.12)  LDD1533  [16]
 LDCM0295  AC34 HEK-293T C185(0.82)  LDD1534  [16]
 LDCM0296  AC35 PaTu 8988t C185(1.21)  LDD1175  [6]
 LDCM0297  AC36 PaTu 8988t C185(1.27)  LDD1176  [6]
 LDCM0298  AC37 PaTu 8988t C185(1.17)  LDD1177  [6]
 LDCM0299  AC38 PaTu 8988t C185(1.14)  LDD1178  [6]
 LDCM0300  AC39 PaTu 8988t C185(1.43)  LDD1179  [6]
 LDCM0301  AC4 HEK-293T C185(1.11)  LDD0899  [6]
 LDCM0302  AC40 PaTu 8988t C185(1.17)  LDD1181  [6]
 LDCM0303  AC41 PaTu 8988t C185(1.21)  LDD1182  [6]
 LDCM0304  AC42 PaTu 8988t C185(1.23)  LDD1183  [6]
 LDCM0305  AC43 PaTu 8988t C185(1.21)  LDD1184  [6]
 LDCM0306  AC44 PaTu 8988t C185(1.17)  LDD1185  [6]
 LDCM0307  AC45 PaTu 8988t C185(1.41)  LDD1186  [6]
 LDCM0308  AC46 HEK-293T C185(0.87)  LDD0906  [6]
 LDCM0309  AC47 HEK-293T C185(1.01)  LDD0907  [6]
 LDCM0310  AC48 HEK-293T C185(0.94)  LDD0908  [6]
 LDCM0311  AC49 HEK-293T C185(1.14)  LDD0909  [6]
 LDCM0312  AC5 HEK-293T C185(0.94)  LDD0910  [6]
 LDCM0313  AC50 HEK-293T C185(0.99)  LDD0911  [6]
 LDCM0314  AC51 HEK-293T C185(1.12)  LDD0912  [6]
 LDCM0315  AC52 HEK-293T C185(1.13)  LDD0913  [6]
 LDCM0316  AC53 HEK-293T C185(1.01)  LDD0914  [6]
 LDCM0317  AC54 HEK-293T C185(1.04)  LDD0915  [6]
 LDCM0318  AC55 HEK-293T C185(1.18)  LDD0916  [6]
 LDCM0319  AC56 HEK-293T C185(0.93)  LDD0917  [6]
 LDCM0320  AC57 PaTu 8988t C185(1.37)  LDD1199  [6]
 LDCM0321  AC58 PaTu 8988t C185(1.19)  LDD1200  [6]
 LDCM0322  AC59 PaTu 8988t C185(1.27)  LDD1201  [6]
 LDCM0323  AC6 HEK-293T C185(1.05)  LDD0921  [6]
 LDCM0324  AC60 PaTu 8988t C185(1.23)  LDD1203  [6]
 LDCM0325  AC61 PaTu 8988t C185(1.01)  LDD1204  [6]
 LDCM0326  AC62 PaTu 8988t C185(1.23)  LDD1205  [6]
 LDCM0327  AC63 PaTu 8988t C185(1.17)  LDD1206  [6]
 LDCM0328  AC64 PaTu 8988t C185(1.19)  LDD1207  [6]
 LDCM0329  AC65 PaTu 8988t C185(1.05)  LDD1208  [6]
 LDCM0330  AC66 PaTu 8988t C185(1.01)  LDD1209  [6]
 LDCM0331  AC67 PaTu 8988t C185(1.20)  LDD1210  [6]
 LDCM0332  AC68 PaTu 8988t C185(0.89)  LDD1211  [6]
 LDCM0333  AC69 PaTu 8988t C185(0.99)  LDD1212  [6]
 LDCM0334  AC7 HEK-293T C185(1.06)  LDD0932  [6]
 LDCM0335  AC70 PaTu 8988t C185(1.08)  LDD1214  [6]
 LDCM0336  AC71 PaTu 8988t C185(0.92)  LDD1215  [6]
 LDCM0337  AC72 PaTu 8988t C185(0.81)  LDD1216  [6]
 LDCM0338  AC73 PaTu 8988t C185(0.84)  LDD1217  [6]
 LDCM0339  AC74 PaTu 8988t C185(1.01)  LDD1218  [6]
 LDCM0340  AC75 PaTu 8988t C185(0.95)  LDD1219  [6]
 LDCM0341  AC76 PaTu 8988t C185(0.89)  LDD1220  [6]
 LDCM0342  AC77 PaTu 8988t C185(0.90)  LDD1221  [6]
 LDCM0343  AC78 PaTu 8988t C185(0.95)  LDD1222  [6]
 LDCM0344  AC79 PaTu 8988t C185(0.93)  LDD1223  [6]
 LDCM0345  AC8 HEK-293T C185(1.30)  LDD0943  [6]
 LDCM0346  AC80 PaTu 8988t C185(0.87)  LDD1225  [6]
 LDCM0347  AC81 PaTu 8988t C185(0.92)  LDD1226  [6]
 LDCM0348  AC82 PaTu 8988t C185(1.04)  LDD1227  [6]
 LDCM0349  AC83 PaTu 8988t C185(0.70)  LDD1228  [6]
 LDCM0350  AC84 PaTu 8988t C185(0.72)  LDD1229  [6]
 LDCM0351  AC85 PaTu 8988t C185(0.63)  LDD1230  [6]
 LDCM0352  AC86 PaTu 8988t C185(0.66)  LDD1231  [6]
 LDCM0353  AC87 PaTu 8988t C185(0.66)  LDD1232  [6]
 LDCM0354  AC88 PaTu 8988t C185(0.84)  LDD1233  [6]
 LDCM0355  AC89 PaTu 8988t C185(0.85)  LDD1234  [6]
 LDCM0357  AC90 PaTu 8988t C185(0.66)  LDD1236  [6]
 LDCM0358  AC91 PaTu 8988t C185(0.66)  LDD1237  [6]
 LDCM0359  AC92 PaTu 8988t C185(0.65)  LDD1238  [6]
 LDCM0360  AC93 PaTu 8988t C185(0.63)  LDD1239  [6]
 LDCM0361  AC94 PaTu 8988t C185(0.74)  LDD1240  [6]
 LDCM0362  AC95 PaTu 8988t C185(0.76)  LDD1241  [6]
 LDCM0363  AC96 PaTu 8988t C185(0.64)  LDD1242  [6]
 LDCM0364  AC97 PaTu 8988t C185(0.71)  LDD1243  [6]
 LDCM0365  AC98 PaTu 8988t C185(1.16)  LDD1244  [6]
 LDCM0366  AC99 PaTu 8988t C185(0.96)  LDD1245  [6]
 LDCM0248  AKOS034007472 HEK-293T C185(1.27)  LDD0846  [6]
 LDCM0356  AKOS034007680 HEK-293T C185(1.34)  LDD0954  [6]
 LDCM0275  AKOS034007705 HEK-293T C185(1.49)  LDD0873  [6]
 LDCM0156  Aniline NCI-H1299 12.42  LDD0403  [1]
 LDCM0367  CL1 HCT 116 C185(1.45)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C185(1.09)  LDD0685  [6]
 LDCM0369  CL100 HEK-293T C185(0.90)  LDD0967  [6]
 LDCM0370  CL101 HEK-293T C185(1.32)  LDD0968  [6]
 LDCM0371  CL102 HEK-293T C185(1.34)  LDD0969  [6]
 LDCM0372  CL103 HEK-293T C185(1.51)  LDD0970  [6]
 LDCM0373  CL104 HEK-293T C185(1.51)  LDD0971  [6]
 LDCM0374  CL105 PaTu 8988t C185(1.19)  LDD1253  [6]
 LDCM0375  CL106 PaTu 8988t C185(1.15)  LDD1254  [6]
 LDCM0376  CL107 PaTu 8988t C185(0.96)  LDD1255  [6]
 LDCM0377  CL108 PaTu 8988t C185(1.14)  LDD1256  [6]
 LDCM0378  CL109 PaTu 8988t C185(1.44)  LDD1257  [6]
 LDCM0379  CL11 HCT 116 C185(1.14)  LDD0696  [6]
 LDCM0380  CL110 PaTu 8988t C185(1.32)  LDD1259  [6]
 LDCM0381  CL111 PaTu 8988t C185(1.48)  LDD1260  [6]
 LDCM0382  CL112 HEK-293T C185(1.11)  LDD1586  [16]
 LDCM0383  CL113 HEK-293T C185(0.95)  LDD1587  [16]
 LDCM0384  CL114 HEK-293T C185(0.84)  LDD1588  [16]
 LDCM0385  CL115 HEK-293T C185(1.01)  LDD1589  [16]
 LDCM0386  CL116 HEK-293T C185(1.00)  LDD1590  [16]
 LDCM0387  CL117 PaTu 8988t C185(1.14)  LDD1266  [6]
 LDCM0388  CL118 PaTu 8988t C185(1.04)  LDD1267  [6]
 LDCM0389  CL119 PaTu 8988t C185(1.38)  LDD1268  [6]
 LDCM0390  CL12 HCT 116 C185(1.39)  LDD0707  [6]
 LDCM0391  CL120 PaTu 8988t C185(1.61)  LDD1270  [6]
 LDCM0392  CL121 HEK-293T C185(1.02)  LDD0990  [6]
 LDCM0393  CL122 HEK-293T C185(1.11)  LDD0991  [6]
 LDCM0394  CL123 HEK-293T C185(1.04)  LDD0992  [6]
 LDCM0395  CL124 HEK-293T C185(1.27)  LDD0993  [6]
 LDCM0396  CL125 PaTu 8988t C185(1.21)  LDD1275  [6]
 LDCM0397  CL126 PaTu 8988t C185(1.23)  LDD1276  [6]
 LDCM0398  CL127 PaTu 8988t C185(1.46)  LDD1277  [6]
 LDCM0399  CL128 PaTu 8988t C185(1.35)  LDD1278  [6]
 LDCM0400  CL13 HCT 116 C185(1.33)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C185(1.47)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C185(1.23)  LDD0719  [6]
 LDCM0403  CL16 PaTu 8988t C185(1.76)  LDD1282  [6]
 LDCM0404  CL17 PaTu 8988t C185(1.12)  LDD1283  [6]
 LDCM0405  CL18 PaTu 8988t C185(1.31)  LDD1284  [6]
 LDCM0406  CL19 PaTu 8988t C185(1.07)  LDD1285  [6]
 LDCM0407  CL2 HCT 116 C185(1.05)  LDD0724  [6]
 LDCM0408  CL20 PaTu 8988t C185(1.78)  LDD1287  [6]
 LDCM0409  CL21 PaTu 8988t C185(1.95)  LDD1288  [6]
 LDCM0410  CL22 PaTu 8988t C185(1.50)  LDD1289  [6]
 LDCM0411  CL23 PaTu 8988t C185(1.24)  LDD1290  [6]
 LDCM0412  CL24 PaTu 8988t C185(0.92)  LDD1291  [6]
 LDCM0413  CL25 PaTu 8988t C185(0.97)  LDD1292  [6]
 LDCM0414  CL26 PaTu 8988t C185(1.15)  LDD1293  [6]
 LDCM0415  CL27 PaTu 8988t C185(1.07)  LDD1294  [6]
 LDCM0416  CL28 PaTu 8988t C185(1.49)  LDD1295  [6]
 LDCM0417  CL29 PaTu 8988t C185(1.52)  LDD1296  [6]
 LDCM0418  CL3 HCT 116 C185(0.98)  LDD0735  [6]
 LDCM0419  CL30 PaTu 8988t C185(1.10)  LDD1298  [6]
 LDCM0420  CL31 HEK-293T C185(1.24)  LDD1624  [16]
 LDCM0421  CL32 HEK-293T C185(0.95)  LDD1625  [16]
 LDCM0422  CL33 HEK-293T C185(0.73)  LDD1626  [16]
 LDCM0423  CL34 HEK-293T C185(0.92)  LDD1627  [16]
 LDCM0424  CL35 HEK-293T C185(0.93)  LDD1628  [16]
 LDCM0425  CL36 HEK-293T C185(0.93)  LDD1629  [16]
 LDCM0426  CL37 HEK-293T C185(0.88)  LDD1630  [16]
 LDCM0428  CL39 HEK-293T C185(1.05)  LDD1632  [16]
 LDCM0429  CL4 HCT 116 C185(1.28)  LDD0746  [6]
 LDCM0430  CL40 HEK-293T C185(0.95)  LDD1634  [16]
 LDCM0431  CL41 HEK-293T C185(0.98)  LDD1635  [16]
 LDCM0432  CL42 HEK-293T C185(0.92)  LDD1636  [16]
 LDCM0433  CL43 HEK-293T C185(1.15)  LDD1637  [16]
 LDCM0434  CL44 HEK-293T C185(0.98)  LDD1638  [16]
 LDCM0435  CL45 HEK-293T C185(0.94)  LDD1639  [16]
 LDCM0436  CL46 HEK-293T C185(0.97)  LDD1034  [6]
 LDCM0437  CL47 HEK-293T C185(0.90)  LDD1035  [6]
 LDCM0438  CL48 HEK-293T C185(0.88)  LDD1036  [6]
 LDCM0439  CL49 HEK-293T C185(1.09)  LDD1037  [6]
 LDCM0440  CL5 HCT 116 C185(1.36)  LDD0757  [6]
 LDCM0441  CL50 HEK-293T C185(0.99)  LDD1039  [6]
 LDCM0442  CL51 HEK-293T C185(0.87)  LDD1040  [6]
 LDCM0443  CL52 HEK-293T C185(0.74)  LDD1041  [6]
 LDCM0444  CL53 HEK-293T C185(0.71)  LDD1042  [6]
 LDCM0445  CL54 HEK-293T C185(0.75)  LDD1043  [6]
 LDCM0446  CL55 HEK-293T C185(0.85)  LDD1044  [6]
 LDCM0447  CL56 HEK-293T C185(0.75)  LDD1045  [6]
 LDCM0448  CL57 HEK-293T C185(0.99)  LDD1046  [6]
 LDCM0449  CL58 HEK-293T C185(0.98)  LDD1047  [6]
 LDCM0450  CL59 HEK-293T C185(1.02)  LDD1048  [6]
 LDCM0451  CL6 HCT 116 C185(1.26)  LDD0768  [6]
 LDCM0452  CL60 HEK-293T C185(1.55)  LDD1050  [6]
 LDCM0453  CL61 HCT 116 C185(0.81)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C185(1.15)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C185(1.33)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C185(0.84)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C185(0.87)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C185(0.83)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C185(1.22)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C185(1.08)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C185(1.24)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C185(0.97)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C185(0.81)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C185(0.97)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C185(0.77)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C185(1.09)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C185(0.72)  LDD0784  [6]
 LDCM0469  CL76 PaTu 8988t C185(1.07)  LDD1348  [6]
 LDCM0470  CL77 PaTu 8988t C185(1.43)  LDD1349  [6]
 LDCM0471  CL78 PaTu 8988t C185(1.16)  LDD1350  [6]
 LDCM0472  CL79 PaTu 8988t C185(1.00)  LDD1351  [6]
 LDCM0473  CL8 HCT 116 C185(1.73)  LDD0790  [6]
 LDCM0474  CL80 PaTu 8988t C185(1.01)  LDD1353  [6]
 LDCM0475  CL81 PaTu 8988t C185(1.32)  LDD1354  [6]
 LDCM0476  CL82 PaTu 8988t C185(1.08)  LDD1355  [6]
 LDCM0477  CL83 PaTu 8988t C185(1.16)  LDD1356  [6]
 LDCM0478  CL84 PaTu 8988t C185(1.50)  LDD1357  [6]
 LDCM0479  CL85 PaTu 8988t C185(1.40)  LDD1358  [6]
 LDCM0480  CL86 PaTu 8988t C185(1.11)  LDD1359  [6]
 LDCM0481  CL87 PaTu 8988t C185(1.37)  LDD1360  [6]
 LDCM0482  CL88 PaTu 8988t C185(1.21)  LDD1361  [6]
 LDCM0483  CL89 PaTu 8988t C185(1.14)  LDD1362  [6]
 LDCM0484  CL9 HCT 116 C185(1.39)  LDD0801  [6]
 LDCM0485  CL90 PaTu 8988t C185(1.52)  LDD1364  [6]
 LDCM0486  CL91 HEK-293T C185(0.99)  LDD1084  [6]
 LDCM0487  CL92 HEK-293T C185(1.00)  LDD1085  [6]
 LDCM0488  CL93 HEK-293T C185(0.71)  LDD1086  [6]
 LDCM0489  CL94 HEK-293T C185(0.94)  LDD1087  [6]
 LDCM0490  CL95 HEK-293T C185(1.06)  LDD1088  [6]
 LDCM0491  CL96 HEK-293T C185(0.88)  LDD1089  [6]
 LDCM0492  CL97 HEK-293T C185(1.00)  LDD1090  [6]
 LDCM0493  CL98 HEK-293T C185(1.15)  LDD1091  [6]
 LDCM0494  CL99 HEK-293T C185(0.84)  LDD1092  [6]
 LDCM0495  E2913 HEK-293T C185(0.98)  LDD1698  [16]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [5]
 LDCM0573  Fragment11 Ramos C185(1.70)  LDD2190  [17]
 LDCM0576  Fragment14 Ramos C185(3.88)  LDD2193  [17]
 LDCM0586  Fragment28 Ramos C185(1.26)  LDD2198  [17]
 LDCM0468  Fragment33 HCT 116 C185(0.79)  LDD0785  [6]
 LDCM0427  Fragment51 HEK-293T C185(0.88)  LDD1631  [16]
 LDCM0022  KB02 HEK-293T C185(0.93)  LDD1492  [16]
 LDCM0023  KB03 HEK-293T C185(0.95)  LDD1497  [16]
 LDCM0024  KB05 COLO792 C185(1.80)  LDD3310  [18]
 LDCM0131  RA190 MM1.R C185(1.71)  LDD0304  [19]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine/threonine-protein kinase PAK 5 (PAK5) STE Ser/Thr protein kinase family Q9P286
Ras-related protein Rab-33A (RAB33A) Rab family Q14088
Terminal nucleotidyltransferase 5B (TENT5B) TENT family Q96A09
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heat shock-related 70 kDa protein 2 (HSPA2) Heat shock protein 70 family P54652
Protein LDOC1 (LDOC1) LDOC1 family O95751
CD2 antigen cytoplasmic tail-binding protein 2 (CD2BP2) . O95400
F-box only protein 7 (FBXO7) . Q9Y3I1
RNA binding protein fox-1 homolog 1 (RBFOX1) . Q9NWB1

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
11 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
12 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
15 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
16 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
17 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
18 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
19 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.