Details of the Target

General Information of Target

Target ID LDTP08793
Target Name Armadillo repeat-containing protein 10 (ARMC10)
Gene Name ARMC10
Gene ID 83787
Synonyms
SVH; Armadillo repeat-containing protein 10; Splicing variant involved in hepatocarcinogenesis protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGGPRGAGWVAAGLLLGAGACYCIYRLTRGRRRGDRELGIRSSKSAGALEEGTSEGQLCG
RSARPQTGGTWESQWSKTSQPEDLTDGSYDDVLNAEQLQKLLYLLESTEDPVIIERALIT
LGNNAAFSVNQAIIRELGGIPIVANKINHSNQSIKEKALNALNNLSVNVENQIKIKIYIS
QVCEDVFSGPLNSAVQLAGLTLLTNMTVTNDHQHMLHSYITDLFQVLLTGNGNTKVQVLK
LLLNLSENPAMTEGLLRAQVDSSFLSLYDSHVAKEILLRVLTLFQNIKNCLKIEGHLAVQ
PTFTEGSLFFLLHGEECAQKIRALVDHHDAEVKEKVVTIIPKI
Target Bioclass
Other
Subcellular location
Endoplasmic reticulum membrane
Function May play a role in cell survival and cell growth. May suppress the transcriptional activity of p53/TP53.
Uniprot ID
Q8N2F6
Ensemble ID
ENST00000323716.8
HGNC ID
HGNC:21706

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
C4II SNV: p.G13S DBIA    Probe Info 
RPMI7951 SNV: p.D86E DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y103(5.11)  LDD0260  [2]
STPyne
 Probe Info  		K155(3.88)  LDD0277  [3]
AHL-Pu-1
 Probe Info  		C59(2.55)  LDD0171  [4]
EA-probe
 Probe Info  		N.A.  LDD0440  [5]
IA-alkyne
 Probe Info  		C59(8.95)  LDD1705  [6]
DBIA
 Probe Info  		C59(1.60)  LDD0078  [7]
IPM
 Probe Info  		N.A.  LDD0025  [8]
TFBX
 Probe Info  		N.A.  LDD0027  [8]
WYneN
 Probe Info  		N.A.  LDD0021  [9]
VSF
 Probe Info  		N.A.  LDD0007  [9]
AOyne
 Probe Info  		15.00  LDD0443  [10]
NAIA_5
 Probe Info  		N.A.  LDD2223  [11]
PAL-AfBPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		9.19  LDD1740  [12]
C091
 Probe Info  		18.25  LDD1782  [12]
C092
 Probe Info  		26.54  LDD1783  [12]
C094
 Probe Info  		51.98  LDD1785  [12]
C106
 Probe Info  		18.64  LDD1793  [12]
C178
 Probe Info  		19.43  LDD1857  [12]
C289
 Probe Info  		27.67  LDD1959  [12]
C349
 Probe Info  		9.45  LDD2010  [12]
C350
 Probe Info  		24.59  LDD2011  [12]
C362
 Probe Info  		36.00  LDD2023  [12]
C376
 Probe Info  		7.21  LDD2036  [12]
C380
 Probe Info  		6.87  LDD2039  [12]
C382
 Probe Info  		10.63  LDD2041  [12]
C388
 Probe Info  		67.65  LDD2047  [12]
FFF probe11
 Probe Info  		16.38  LDD0472  [13]
FFF probe13
 Probe Info  		12.88  LDD0476  [13]
FFF probe3
 Probe Info  		17.41  LDD0465  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C59(2.55)  LDD0171  [4]
 LDCM0214  AC1 HCT 116 C59(0.65)  LDD0531  [7]
 LDCM0215  AC10 HEK-293T C317(0.97)  LDD1508  [14]
 LDCM0226  AC11 HEK-293T C317(0.98)  LDD1509  [14]
 LDCM0246  AC128 HCT 116 C59(0.75)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C59(0.98)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C59(1.16)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C59(0.82)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C59(1.04)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C59(1.03)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C59(1.05)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C59(0.91)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C59(1.01)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C59(0.93)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C59(1.17)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C59(1.14)  LDD0575  [7]
 LDCM0259  AC14 HEK-293T C317(0.98); C59(0.99)  LDD1512  [14]
 LDCM0260  AC140 HCT 116 C59(1.23)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C59(1.25)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C59(0.99)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C59(0.95)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C59(1.38)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C59(1.57)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C59(1.44)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C59(1.06)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C59(1.75)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C59(1.32)  LDD0586  [7]
 LDCM0270  AC15 HEK-293T C317(1.06); C59(1.10)  LDD1513  [14]
 LDCM0271  AC150 HCT 116 C59(1.06)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C59(1.28)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C59(1.28)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C59(1.97)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C59(1.43)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C59(1.44)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C59(1.26)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C59(1.54)  LDD2161  [7]
 LDCM0276  AC17 PaTu 8988t C59(1.14)  LDD1155  [7]
 LDCM0277  AC18 PaTu 8988t C59(1.51)  LDD1156  [7]
 LDCM0278  AC19 PaTu 8988t C59(1.34)  LDD1157  [7]
 LDCM0279  AC2 HCT 116 C59(0.90)  LDD0596  [7]
 LDCM0280  AC20 PaTu 8988t C59(1.44)  LDD1159  [7]
 LDCM0281  AC21 PaTu 8988t C59(1.41)  LDD1160  [7]
 LDCM0282  AC22 PaTu 8988t C59(1.68)  LDD1161  [7]
 LDCM0283  AC23 PaTu 8988t C59(1.58)  LDD1162  [7]
 LDCM0284  AC24 PaTu 8988t C59(1.59)  LDD1163  [7]
 LDCM0285  AC25 HEK-293T C317(0.94); C59(1.09)  LDD1524  [14]
 LDCM0286  AC26 HEK-293T C317(0.95)  LDD1525  [14]
 LDCM0287  AC27 HEK-293T C317(1.09)  LDD1526  [14]
 LDCM0289  AC29 HEK-293T C317(1.15); C59(0.94)  LDD1528  [14]
 LDCM0290  AC3 HCT 116 C59(0.77)  LDD0607  [7]
 LDCM0291  AC30 HEK-293T C317(0.93); C59(1.02)  LDD1530  [14]
 LDCM0292  AC31 HEK-293T C317(1.15); C59(1.06)  LDD1531  [14]
 LDCM0293  AC32 HEK-293T C317(1.04); C59(0.97)  LDD1532  [14]
 LDCM0294  AC33 HEK-293T C317(0.99); C59(1.06)  LDD1533  [14]
 LDCM0295  AC34 HEK-293T C317(1.00)  LDD1534  [14]
 LDCM0296  AC35 HEK-293T C317(1.08)  LDD1535  [14]
 LDCM0298  AC37 HEK-293T C317(0.98); C59(0.99)  LDD1537  [14]
 LDCM0299  AC38 HEK-293T C317(1.14); C59(1.30)  LDD1538  [14]
 LDCM0300  AC39 HEK-293T C317(1.04); C59(1.04)  LDD1539  [14]
 LDCM0301  AC4 HCT 116 C59(0.78)  LDD0618  [7]
 LDCM0302  AC40 HEK-293T C317(1.06); C59(1.02)  LDD1541  [14]
 LDCM0303  AC41 HEK-293T C317(0.99); C59(1.03)  LDD1542  [14]
 LDCM0304  AC42 HEK-293T C317(0.92)  LDD1543  [14]
 LDCM0305  AC43 HEK-293T C317(1.00)  LDD1544  [14]
 LDCM0307  AC45 HEK-293T C317(1.02); C59(0.99)  LDD1546  [14]
 LDCM0308  AC46 PaTu 8988t C59(1.08)  LDD1187  [7]
 LDCM0309  AC47 PaTu 8988t C59(1.28)  LDD1188  [7]
 LDCM0310  AC48 PaTu 8988t C59(1.33)  LDD1189  [7]
 LDCM0311  AC49 PaTu 8988t C59(1.51)  LDD1190  [7]
 LDCM0312  AC5 HCT 116 C59(0.68)  LDD0629  [7]
 LDCM0313  AC50 PaTu 8988t C59(1.44)  LDD1192  [7]
 LDCM0314  AC51 PaTu 8988t C59(0.75)  LDD1193  [7]
 LDCM0315  AC52 PaTu 8988t C59(1.29)  LDD1194  [7]
 LDCM0316  AC53 PaTu 8988t C59(1.74)  LDD1195  [7]
 LDCM0317  AC54 PaTu 8988t C59(1.81)  LDD1196  [7]
 LDCM0318  AC55 PaTu 8988t C59(1.23)  LDD1197  [7]
 LDCM0319  AC56 PaTu 8988t C59(1.49)  LDD1198  [7]
 LDCM0320  AC57 HEK-293T C317(0.91); C59(1.08)  LDD1559  [14]
 LDCM0321  AC58 HEK-293T C317(1.03)  LDD1560  [14]
 LDCM0322  AC59 HEK-293T C317(1.03)  LDD1561  [14]
 LDCM0323  AC6 HEK-293T C317(1.04); C59(1.08)  LDD1562  [14]
 LDCM0325  AC61 HEK-293T C317(1.09); C59(1.03)  LDD1564  [14]
 LDCM0326  AC62 HEK-293T C317(1.00); C59(1.06)  LDD1565  [14]
 LDCM0327  AC63 HEK-293T C317(1.10); C59(0.99)  LDD1566  [14]
 LDCM0328  AC64 HEK-293T C317(1.02); C59(0.93)  LDD1567  [14]
 LDCM0332  AC68 HCT 116 C59(1.35)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C59(0.86)  LDD0650  [7]
 LDCM0334  AC7 HEK-293T C317(1.04); C59(1.18)  LDD1568  [14]
 LDCM0335  AC70 HCT 116 C59(0.83)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C59(0.81)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C59(1.03)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C59(1.24)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C59(1.37)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C59(1.37)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C59(1.19)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C59(1.28)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C59(1.17)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C59(1.16)  LDD0661  [7]
 LDCM0345  AC8 HEK-293T C317(1.07); C59(1.07)  LDD1569  [14]
 LDCM0346  AC80 HCT 116 C59(0.81)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C59(0.82)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C59(1.24)  LDD0665  [7]
 LDCM0349  AC83 PaTu 8988t C59(0.97)  LDD1228  [7]
 LDCM0350  AC84 PaTu 8988t C59(0.84)  LDD1229  [7]
 LDCM0351  AC85 PaTu 8988t C59(1.15)  LDD1230  [7]
 LDCM0352  AC86 PaTu 8988t C59(1.13)  LDD1231  [7]
 LDCM0353  AC87 PaTu 8988t C59(1.15)  LDD1232  [7]
 LDCM0354  AC88 PaTu 8988t C59(1.08)  LDD1233  [7]
 LDCM0355  AC89 PaTu 8988t C59(0.93)  LDD1234  [7]
 LDCM0357  AC90 PaTu 8988t C59(1.23)  LDD1236  [7]
 LDCM0358  AC91 PaTu 8988t C59(0.97)  LDD1237  [7]
 LDCM0359  AC92 PaTu 8988t C59(0.91)  LDD1238  [7]
 LDCM0360  AC93 PaTu 8988t C59(1.01)  LDD1239  [7]
 LDCM0361  AC94 PaTu 8988t C59(1.05)  LDD1240  [7]
 LDCM0362  AC95 PaTu 8988t C59(1.09)  LDD1241  [7]
 LDCM0363  AC96 PaTu 8988t C59(0.93)  LDD1242  [7]
 LDCM0364  AC97 PaTu 8988t C59(1.00)  LDD1243  [7]
 LDCM0248  AKOS034007472 HEK-293T C317(0.96); C59(1.07)  LDD1511  [14]
 LDCM0356  AKOS034007680 HEK-293T C317(0.97); C59(1.00)  LDD1570  [14]
 LDCM0275  AKOS034007705 HEK-293T C317(1.08); C59(1.00)  LDD1514  [14]
 LDCM0156  Aniline NCI-H1299 12.76  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C59(1.60)  LDD0078  [7]
 LDCM0367  CL1 HEK-293T C317(1.08); C59(1.01)  LDD1571  [14]
 LDCM0368  CL10 HEK-293T C317(1.48); C59(1.18)  LDD1572  [14]
 LDCM0369  CL100 HCT 116 C59(0.86)  LDD0686  [7]
 LDCM0370  CL101 HEK-293T C317(1.02); C59(0.97)  LDD1574  [14]
 LDCM0371  CL102 HEK-293T C317(1.09); C59(1.14)  LDD1575  [14]
 LDCM0372  CL103 HEK-293T C59(0.96)  LDD1576  [14]
 LDCM0373  CL104 HEK-293T C317(1.10); C59(0.88)  LDD1577  [14]
 LDCM0374  CL105 PaTu 8988t C59(1.24)  LDD1253  [7]
 LDCM0375  CL106 PaTu 8988t C59(1.07)  LDD1254  [7]
 LDCM0376  CL107 PaTu 8988t C59(1.17)  LDD1255  [7]
 LDCM0377  CL108 PaTu 8988t C59(1.14)  LDD1256  [7]
 LDCM0378  CL109 PaTu 8988t C59(1.56)  LDD1257  [7]
 LDCM0379  CL11 HEK-293T C317(1.47); C59(1.20)  LDD1583  [14]
 LDCM0380  CL110 PaTu 8988t C59(1.12)  LDD1259  [7]
 LDCM0381  CL111 PaTu 8988t C59(1.63)  LDD1260  [7]
 LDCM0382  CL112 HEK-293T C317(0.95); C59(1.13)  LDD1586  [14]
 LDCM0383  CL113 HEK-293T C317(1.06); C59(1.00)  LDD1587  [14]
 LDCM0384  CL114 HEK-293T C317(1.04); C59(1.10)  LDD1588  [14]
 LDCM0385  CL115 HEK-293T C59(1.06)  LDD1589  [14]
 LDCM0386  CL116 HEK-293T C317(0.96); C59(1.05)  LDD1590  [14]
 LDCM0387  CL117 HEK-293T C317(1.15); C59(0.92)  LDD1591  [14]
 LDCM0388  CL118 HEK-293T C317(1.17); C59(0.99)  LDD1592  [14]
 LDCM0389  CL119 HEK-293T C59(1.06)  LDD1593  [14]
 LDCM0390  CL12 HEK-293T C317(1.42); C59(1.23)  LDD1594  [14]
 LDCM0391  CL120 HEK-293T C317(1.11); C59(0.83)  LDD1595  [14]
 LDCM0392  CL121 PaTu 8988t C59(1.15)  LDD1271  [7]
 LDCM0393  CL122 PaTu 8988t C59(1.35)  LDD1272  [7]
 LDCM0394  CL123 PaTu 8988t C59(1.57)  LDD1273  [7]
 LDCM0395  CL124 PaTu 8988t C59(1.45)  LDD1274  [7]
 LDCM0396  CL125 HEK-293T C317(0.97); C59(0.83)  LDD1600  [14]
 LDCM0397  CL126 HEK-293T C317(1.16); C59(0.95)  LDD1601  [14]
 LDCM0398  CL127 HEK-293T C59(0.95)  LDD1602  [14]
 LDCM0399  CL128 HEK-293T C317(1.05); C59(0.84)  LDD1603  [14]
 LDCM0400  CL13 HEK-293T C317(1.16); C59(1.33)  LDD1604  [14]
 LDCM0401  CL14 HEK-293T C317(1.25); C59(1.13)  LDD1605  [14]
 LDCM0402  CL15 HEK-293T C59(1.11)  LDD1606  [14]
 LDCM0403  CL16 HCT 116 C59(1.35)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C59(1.03)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C59(1.14)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C59(1.26)  LDD0723  [7]
 LDCM0407  CL2 HEK-293T C317(1.22); C59(1.11)  LDD1611  [14]
 LDCM0408  CL20 HCT 116 C59(1.21)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C59(1.39)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C59(1.42)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C59(1.09)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C59(1.25)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C59(1.53)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C59(1.45)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C59(1.34)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C59(1.33)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C59(1.35)  LDD0734  [7]
 LDCM0418  CL3 HEK-293T C59(0.93)  LDD1622  [14]
 LDCM0419  CL30 HCT 116 C59(1.30)  LDD0736  [7]
 LDCM0420  CL31 PaTu 8988t C59(1.11)  LDD1299  [7]
 LDCM0421  CL32 PaTu 8988t C59(1.52)  LDD1300  [7]
 LDCM0422  CL33 PaTu 8988t C59(1.58)  LDD1301  [7]
 LDCM0423  CL34 PaTu 8988t C59(1.57)  LDD1302  [7]
 LDCM0424  CL35 PaTu 8988t C59(1.53)  LDD1303  [7]
 LDCM0425  CL36 PaTu 8988t C59(1.51)  LDD1304  [7]
 LDCM0426  CL37 PaTu 8988t C59(1.68)  LDD1305  [7]
 LDCM0428  CL39 PaTu 8988t C59(1.58)  LDD1307  [7]
 LDCM0429  CL4 HEK-293T C317(1.10); C59(1.12)  LDD1633  [14]
 LDCM0430  CL40 PaTu 8988t C59(1.40)  LDD1309  [7]
 LDCM0431  CL41 PaTu 8988t C59(1.58)  LDD1310  [7]
 LDCM0432  CL42 PaTu 8988t C59(1.91)  LDD1311  [7]
 LDCM0433  CL43 PaTu 8988t C59(2.56)  LDD1312  [7]
 LDCM0434  CL44 PaTu 8988t C59(2.00)  LDD1313  [7]
 LDCM0435  CL45 PaTu 8988t C59(1.33)  LDD1314  [7]
 LDCM0436  CL46 HCT 116 C59(1.16)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C59(1.07)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C59(1.17)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C59(1.25)  LDD0756  [7]
 LDCM0440  CL5 HEK-293T C317(1.10); C59(0.95)  LDD1644  [14]
 LDCM0441  CL50 HCT 116 C59(1.04)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C59(1.06)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C59(1.16)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C59(0.88)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C59(0.93)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C59(1.06)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C59(0.90)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C59(1.26)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C59(0.97)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C59(1.29)  LDD0767  [7]
 LDCM0451  CL6 HEK-293T C317(1.08)  LDD1654  [14]
 LDCM0452  CL60 HCT 116 C59(1.26)  LDD0769  [7]
 LDCM0453  CL61 PaTu 8988t C59(1.11)  LDD1332  [7]
 LDCM0454  CL62 PaTu 8988t C59(0.79)  LDD1333  [7]
 LDCM0455  CL63 PaTu 8988t C59(0.85)  LDD1334  [7]
 LDCM0456  CL64 PaTu 8988t C59(1.02)  LDD1335  [7]
 LDCM0457  CL65 PaTu 8988t C59(0.99)  LDD1336  [7]
 LDCM0458  CL66 PaTu 8988t C59(1.02)  LDD1337  [7]
 LDCM0459  CL67 PaTu 8988t C59(1.44)  LDD1338  [7]
 LDCM0460  CL68 PaTu 8988t C59(1.81)  LDD1339  [7]
 LDCM0461  CL69 PaTu 8988t C59(1.62)  LDD1340  [7]
 LDCM0462  CL7 HEK-293T C317(1.12)  LDD1665  [14]
 LDCM0463  CL70 PaTu 8988t C59(1.35)  LDD1342  [7]
 LDCM0464  CL71 PaTu 8988t C59(0.93)  LDD1343  [7]
 LDCM0465  CL72 PaTu 8988t C59(0.87)  LDD1344  [7]
 LDCM0466  CL73 PaTu 8988t C59(1.40)  LDD1345  [7]
 LDCM0467  CL74 PaTu 8988t C59(1.19)  LDD1346  [7]
 LDCM0469  CL76 HEK-293T C317(1.02); C59(0.96)  LDD1672  [14]
 LDCM0470  CL77 HEK-293T C317(0.91); C59(1.19)  LDD1673  [14]
 LDCM0471  CL78 HEK-293T C317(0.98)  LDD1674  [14]
 LDCM0472  CL79 HEK-293T C317(1.21)  LDD1675  [14]
 LDCM0475  CL81 HEK-293T C317(1.14); C59(1.02)  LDD1678  [14]
 LDCM0476  CL82 HEK-293T C317(1.07); C59(1.01)  LDD1679  [14]
 LDCM0477  CL83 HEK-293T C317(1.32); C59(1.19)  LDD1680  [14]
 LDCM0478  CL84 HEK-293T C317(1.27); C59(1.14)  LDD1681  [14]
 LDCM0479  CL85 HEK-293T C317(1.33); C59(0.76)  LDD1682  [14]
 LDCM0480  CL86 HEK-293T C317(1.12); C59(1.01)  LDD1683  [14]
 LDCM0481  CL87 HEK-293T C59(0.96)  LDD1684  [14]
 LDCM0482  CL88 HEK-293T C317(1.12); C59(0.89)  LDD1685  [14]
 LDCM0483  CL89 HEK-293T C317(1.06); C59(0.98)  LDD1686  [14]
 LDCM0484  CL9 HEK-293T C317(1.32); C59(1.14)  LDD1687  [14]
 LDCM0485  CL90 HEK-293T C317(1.06)  LDD1688  [14]
 LDCM0486  CL91 HCT 116 C59(0.43)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C59(0.61)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C59(0.85)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C59(0.77)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C59(0.68)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C59(0.93)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C59(0.84)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C59(0.92)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C59(0.72)  LDD0811  [7]
 LDCM0495  E2913 HEK-293T C59(0.87)  LDD1698  [14]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [5]
 LDCM0625  F8 Ramos C290(0.24); C59(1.29)  LDD2187  [15]
 LDCM0572  Fragment10 Ramos C59(1.99)  LDD2189  [15]
 LDCM0573  Fragment11 Ramos C290(1.33); C59(9.91)  LDD2190  [15]
 LDCM0574  Fragment12 Ramos C59(1.48)  LDD2191  [15]
 LDCM0575  Fragment13 Ramos C59(0.94)  LDD2192  [15]
 LDCM0576  Fragment14 Ramos C59(2.43)  LDD2193  [15]
 LDCM0579  Fragment20 Ramos C59(2.96)  LDD2194  [15]
 LDCM0580  Fragment21 Ramos C59(0.79)  LDD2195  [15]
 LDCM0582  Fragment23 Ramos C59(0.89)  LDD2196  [15]
 LDCM0578  Fragment27 Ramos C59(0.84)  LDD2197  [15]
 LDCM0586  Fragment28 Ramos C290(1.31); C59(0.55)  LDD2198  [15]
 LDCM0588  Fragment30 Ramos C59(1.14)  LDD2199  [15]
 LDCM0589  Fragment31 Ramos C59(0.97)  LDD2200  [15]
 LDCM0590  Fragment32 Ramos C59(1.97)  LDD2201  [15]
 LDCM0468  Fragment33 PaTu 8988t C59(1.06)  LDD1347  [7]
 LDCM0596  Fragment38 Ramos C59(0.76)  LDD2203  [15]
 LDCM0566  Fragment4 Ramos C290(1.68); C59(1.10)  LDD2184  [15]
 LDCM0427  Fragment51 PaTu 8988t C59(1.91)  LDD1306  [7]
 LDCM0610  Fragment52 Ramos C59(2.07)  LDD2204  [15]
 LDCM0614  Fragment56 Ramos C59(1.12)  LDD2205  [15]
 LDCM0569  Fragment7 Ramos C59(1.29)  LDD2186  [15]
 LDCM0571  Fragment9 Ramos C59(2.98)  LDD2188  [15]
 LDCM0022  KB02 HEK-293T C59(0.87)  LDD1492  [14]
 LDCM0023  KB03 HEK-293T C59(1.04)  LDD1497  [14]
 LDCM0024  KB05 Hs 936.T C59(2.80)  LDD3313  [16]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FAM25C (FAM25C) FAM25 family B3EWG5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (SMARCD1) SMARCD family Q96GM5
Transcription elongation factor A protein 2 (TCEA2) TFS-II family Q15560
Calpain small subunit 2 (CAPNS2) . Q96L46

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
6 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
13 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
16 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840