Details of the Target

General Information of Target

Target ID LDTP01316
Target Name Breast cancer anti-estrogen resistance protein 3 (BCAR3)
Gene Name BCAR3
Gene ID 8412
Synonyms
NSP2; SH2D3B; Breast cancer anti-estrogen resistance protein 3; Novel SH2-containing protein 2; SH2 domain-containing protein 3B
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAAGKFASLPRNMPVNHQFPLASSMDLLSSRSPLAEHRPDAYQDVSIHGTLPRKKKGPPP
IRSCDDFSHMGTLPHSKSPRQNSPVTQDGIQESPWQDRHGETFTFRDPHLLDPTVEYVKF
SKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSL
SSPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRP
ISQQSGAIIFQPINRTVPLRCLEEHYGTSPGQAREGSLTKGRPDVAKRLSLTMGGVQARE
QNLPRGNLLRNKEKSGSQPACLDHMQDRRALSLKAHQSESYLPIGCKLPPQSSGVDTSPC
PNSPVFRTGSEPALSPAVVRRVSSDARAGEALRGSDSQLCPKPPPKPCKVPFLKVPSSPS
AWLNSEANYCELNPAFATGCGRGAKLPSCAQGSHTELLTAKQNEAPGPRNSGVNYLILDD
DDRERPWEPAAAQMEKGQWDKGEFVTPLLETVSSFRPNEFESKFLPPENKPLETAMLKRA
KELFTNNDPKVIAQHVLSMDCRVARILGVSEEMRRNMGVSSGLELITLPHGHQLRLDIIE
RHNTMAIGIAVDILGCTGTLEDRAATLSKIIQVAVELKDSMGDLYSFSALMKALEMPQIT
RLEKTWTALRHQYTQTAILYEKQLKPFSKLLHEGRESTCVPPNNVSVPLLMPLVTLMERQ
AVTFEGTDMWEKNDQSCEIMLNHLATARFMAEAADSYRMNAERILAGFQPDEEMNEICKT
EFQMRLLWGSKGAQVNQTERYEKFNQILTALSRKLEPPPVKQAEL
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers. Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis. Promotes insulin-mediated membrane ruffling. In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1. Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity. May inhibit TGFB-SMAD signaling, via facilitating BCAR1 and SMAD2 and/or SMAD3 interaction. Regulates EGF-induced DNA synthesis. Required for the maintenance of ocular lens morphology and structural integrity, potentially via regulation of focal adhesion complex signaling. Acts upstream of PTPRA to regulate the localization of BCAR1 and PTPRA to focal adhesions, via regulation of SRC-mediated phosphorylation of PTPRA. Positively regulates integrin-induced tyrosine phosphorylation of BCAR1. Acts as a guanine nucleotide exchange factor (GEF) for small GTPases RALA, RAP1A and RRAS. However, in a contrasting study, lacks GEF activity towards RAP1.
Uniprot ID
O75815
Ensemble ID
ENST00000260502.11
HGNC ID
HGNC:973

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K200(4.78); K541(6.25); K56(10.00); K814(4.85)  LDD0277  [2]
BTD
 Probe Info  		C449(0.64)  LDD2100  [3]
EA-probe
 Probe Info  		N.A.  LDD0440  [4]
DBIA
 Probe Info  		C400(0.67); C408(0.67); C561(0.98); C737(0.98)  LDD0531  [5]
IA-alkyne
 Probe Info  		C346(0.00); C261(0.00)  LDD0162  [6]
NAIA_4
 Probe Info  		C64(0.00); C261(0.00); C321(0.00); C346(0.00)  LDD2226  [7]
WYneN
 Probe Info  		N.A.  LDD0021  [8]
WYneO
 Probe Info  		N.A.  LDD0022  [8]
IPM
 Probe Info  		C449(0.00); C233(0.00); C400(0.00); C360(0.00)  LDD0147  [9]
TFBX
 Probe Info  		C449(0.00); C778(0.00); C233(0.00); C261(0.00)  LDD0148  [9]
NAIA_5
 Probe Info  		C261(0.00); C699(0.00)  LDD2223  [7]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Kambe_26
 Probe Info  		12.35  LDD0127  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C400(0.67); C408(0.67); C561(0.98); C737(0.98)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C561(1.26); C737(1.14)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C400(0.83); C408(0.83); C561(0.58); C737(1.00)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C400(1.25); C408(1.25); C561(0.65); C737(0.79)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C400(1.50); C408(1.50); C561(0.48); C737(0.98)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C400(1.78); C408(1.78); C561(0.55); C737(0.88)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C400(1.11); C408(1.11); C561(0.50); C737(0.88)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C400(1.48); C408(1.48); C561(0.57); C737(0.99)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C400(1.10); C408(1.10); C561(0.50); C737(0.93)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C400(1.09); C408(1.09); C561(0.58); C737(0.79)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C400(0.94); C408(0.94); C561(0.60); C737(0.82)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C400(1.05); C408(1.05); C561(0.54); C737(0.91)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C561(1.49); C737(0.94)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C400(1.26); C408(1.26); C561(0.54); C737(1.03)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C400(1.22); C408(1.22); C561(0.50); C737(0.76)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C400(1.31); C408(1.31); C561(0.52); C737(0.87)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C400(0.84); C408(0.84); C190(0.71); C737(1.03)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C400(1.03); C408(0.93); C190(0.57); C737(0.96)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C400(0.85); C408(0.92); C190(0.53); C737(0.93)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C400(1.00); C408(1.07); C190(0.65); C737(1.24)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C400(0.80); C408(0.98); C190(0.71); C737(1.14)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C400(0.84); C408(0.88); C190(0.68); C737(0.90)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C400(0.82); C408(0.89); C190(0.59); C737(1.00)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C561(1.22); C737(1.11)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C400(1.32); C408(1.31); C190(0.55); C737(0.95)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C400(0.90); C408(1.12); C190(0.64); C737(0.82)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C400(0.87); C408(0.91); C190(0.68); C737(0.84)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C400(1.00); C408(1.14); C190(0.73); C737(0.73)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C400(0.83); C408(1.05); C190(0.89); C737(0.90)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C400(0.97); C408(1.01); C190(0.76); C737(0.78)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C400(0.91); C408(0.86); C190(0.65); C737(0.98)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C400(0.76); C408(0.89); C190(0.65); C737(1.00)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C400(0.62); C408(0.62); C190(1.39); C561(1.44)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C400(0.52); C408(0.52); C190(1.15); C561(1.16)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C400(0.50); C408(0.50); C190(1.36); C561(1.21)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C400(0.83); C408(0.83); C190(1.21); C561(0.92)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C400(0.60); C408(0.60); C190(1.24); C561(1.56)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C400(0.63); C408(0.63); C190(1.20); C561(1.53)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C400(0.94); C408(0.94); C190(0.76); C561(1.62)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C400(0.64); C408(0.64); C190(1.18); C561(1.52)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C400(0.78); C408(0.78); C190(1.03); C561(1.32)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C400(0.94); C408(0.94); C190(1.06); C561(1.43)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C400(1.61); C408(1.61); C190(0.62); C561(1.49)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C400(0.87); C408(0.87); C190(0.77); C561(1.45)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C561(1.19); C737(1.04)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C400(1.20); C408(1.20); C190(0.60); C561(1.55)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C400(1.13); C408(1.13); C190(0.62); C561(1.65)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C400(0.94); C408(0.94); C190(0.77); C561(1.48)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C400(1.00); C408(1.00); C561(0.97)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C400(0.77); C408(0.77); C561(0.80)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C400(0.82); C408(0.82); C561(0.83)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C400(0.81); C408(0.81); C561(0.91)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C561(0.90); C400(0.95); C408(0.95)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C400(1.03); C408(1.03); C561(1.09)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C561(1.09); C400(1.37); C408(1.37)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C561(0.89); C737(1.12)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C561(0.94); C400(1.20); C408(1.20)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C400(0.77); C408(0.77); C561(1.00)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C561(0.84); C400(1.59); C408(1.59)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C400(0.83); C408(0.83); C561(0.95)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C400(0.81); C408(0.81); C561(0.92)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C400(0.71); C408(0.71); C561(0.79)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C400(0.90); C408(0.90); C561(0.97)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C400(0.88); C408(0.88); C561(1.01)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C561(0.88); C400(0.89); C408(0.89); C737(1.10)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C561(0.62); C737(0.96); C400(1.51); C408(1.51)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C561(0.69); C737(1.04); C400(1.08); C408(1.08)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C400(0.57); C408(0.57); C737(1.17); C561(1.18)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C561(0.81); C737(0.98); C400(1.65); C408(1.65)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C561(0.84); C737(0.89); C400(1.25); C408(1.25)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C737(0.98); C561(1.09); C400(1.11); C408(1.11)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C561(0.82); C737(1.05); C400(1.27); C408(1.27)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C561(0.85); C737(1.13); C400(1.21); C408(1.21)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C737(1.12)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C737(1.13)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C737(1.16)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C737(1.13)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C737(1.29)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C400(0.44); C408(0.44); C737(1.06); C561(1.28)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C737(1.34)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C737(1.15)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C737(1.38)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C737(1.45)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C737(1.05)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C190(0.90); C737(0.92); C400(1.15); C408(1.15)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C737(0.92); C190(1.00); C400(1.28); C408(1.28)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C737(0.80); C190(0.82); C400(1.30); C408(1.30)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C737(0.95); C190(1.11); C400(1.53); C408(1.53)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C190(0.88); C737(1.00); C400(1.28); C408(1.28)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C400(0.48); C408(0.48); C737(0.85); C561(1.05)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C190(0.90); C737(1.00); C400(2.27); C408(2.27)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C737(0.98); C190(0.99); C400(1.83); C408(1.83)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C737(0.91); C190(0.99); C400(2.07); C408(2.07)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C737(0.96); C190(1.06); C400(2.45); C408(2.45)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C737(0.89); C190(1.13); C400(2.84); C408(2.84)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C190(0.86); C737(0.87); C400(2.24); C408(2.24)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C561(0.83); C737(0.96)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C737(0.69); C561(1.25)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C737(0.87); C561(1.00)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C561(0.48); C737(0.88)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C400(0.42); C408(0.42); C737(0.92); C561(1.10)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C561(0.79); C737(0.87)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C561(0.59); C737(0.74)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C561(0.63); C737(0.73)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C737(0.90); C561(0.95)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C737(0.72); C561(0.81)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C737(0.99); C561(1.19)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C737(0.70); C561(0.80)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C190(0.57); C400(0.85); C408(0.85); C561(1.19)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C190(0.52); C561(1.07); C400(1.18); C408(1.18)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C190(0.63); C400(0.74); C408(0.74); C561(1.28)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C561(0.93); C737(1.23)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C190(0.60); C400(0.77); C408(0.77); C561(1.42)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C190(0.67); C400(0.92); C408(0.92); C561(1.25)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C190(0.68); C400(0.74); C408(0.74); C561(1.49)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C190(0.55); C400(0.68); C408(0.68); C561(1.52)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C190(0.64); C400(0.64); C408(0.64); C561(1.48)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C190(0.66); C400(0.95); C408(0.95); C561(1.77)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C190(0.67); C400(0.79); C408(0.79); C561(1.65)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C190(0.63); C400(1.13); C408(1.13); C561(1.32)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C737(0.77); C561(1.12); C400(2.39); C408(2.39)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C737(0.72); C561(1.10); C400(1.41); C408(1.41)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C737(1.06); C561(1.20)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C561(1.01); C400(1.09); C408(1.09); C737(1.12)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C737(0.80); C400(1.14); C408(1.14); C561(1.20)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C561(1.04); C400(1.05); C408(1.05); C737(1.15)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C737(0.99); C400(1.20); C408(1.20); C561(1.26)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C737(0.77); C400(1.05); C408(1.05); C561(1.26)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C400(0.98); C408(0.98); C737(1.05); C561(1.25)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C737(0.90); C400(1.13); C408(1.13); C561(1.15)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C737(0.76); C561(1.20); C400(1.56); C408(1.56)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C737(0.83); C561(0.99); C400(1.20); C408(1.20)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C737(0.99); C561(1.12); C400(1.31); C408(1.31)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C561(0.85); C737(0.95)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C737(0.83); C400(0.96); C408(0.96); C561(1.21)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C737(0.90); C561(0.96); C400(1.63); C408(1.63)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C737(0.93); C561(1.15); C400(1.40); C408(1.40)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C190(0.44); C400(1.03); C408(1.03); C561(1.13)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C190(0.63); C561(1.04); C400(1.04); C408(1.04)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C190(0.62); C561(1.03); C400(1.04); C408(1.04)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C190(0.55); C400(1.09); C408(1.09); C561(1.15)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C190(0.63); C561(1.04); C400(1.08); C408(1.08)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C190(0.53); C561(0.99); C400(1.32); C408(1.32)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C190(0.63); C561(1.00); C400(1.13); C408(1.13)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C190(0.52); C561(1.05); C400(1.25); C408(1.25)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C190(0.61); C400(1.02); C408(1.02); C561(1.19)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C190(0.61); C400(0.98); C408(0.98); C561(1.05)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C190(0.51); C561(1.00); C400(1.42); C408(1.42)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C190(0.76); C400(0.87); C408(0.87); C561(0.96)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C190(0.47); C561(0.92); C400(1.46); C408(1.46)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C190(0.93); C561(1.06); C400(1.20); C408(1.20)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C190(0.55); C561(0.95); C400(1.26); C408(1.26)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C561(0.33); C737(1.01); C400(1.26); C408(1.26)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C561(0.46); C737(0.98); C400(1.31); C408(1.31)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C561(1.47); C737(0.93)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C737(1.05); C561(1.39)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C561(0.87); C737(1.72)  LDD0592  [5]
 LDCM0020  ARS-1620 HCC44 C430(1.43); C440(1.43)  LDD2171  [5]
 LDCM0630  CCW28-3 231MFP C346(0.97)  LDD2214  [11]
 LDCM0632  CL-Sc Hep-G2 C233(20.00); C449(20.00); C261(1.18)  LDD2227  [7]
 LDCM0367  CL1 HCT 116 C737(1.00)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C737(0.92)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C400(0.67); C408(0.67); C737(1.05); C561(1.12)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C561(1.10); C737(1.12)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C737(1.07); C561(1.31)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C737(0.97); C561(1.31)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C737(1.07); C561(1.09)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C561(0.74); C737(1.10); C400(1.20); C408(1.20)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C561(0.71); C400(1.17); C408(1.17); C737(1.23)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C561(0.90); C400(0.99); C408(0.99); C737(1.25)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C400(0.72); C408(0.72); C561(0.83); C737(1.20)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C561(0.78); C400(0.96); C408(0.96); C737(1.07)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C737(0.94)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C561(0.77); C400(0.79); C408(0.79); C737(1.16)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C561(0.76); C737(0.95); C400(1.22); C408(1.22)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C737(0.77)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C737(1.14)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C737(1.31)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C737(0.95)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C737(1.02)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C737(0.89); C190(0.94); C400(4.06); C408(4.06)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C400(0.85); C408(0.85); C190(0.93); C737(1.13)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C190(0.86); C400(0.95); C408(0.95); C737(1.07)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C737(1.06)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C737(1.00); C190(1.01); C400(1.05); C408(1.05)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C737(0.81); C561(0.89)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C561(0.55); C737(0.64)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C737(0.70); C561(0.84)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C737(0.74); C561(0.80)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C400(0.86); C408(0.86); C190(0.91); C561(1.24)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C190(0.78); C400(0.84); C408(0.84); C561(1.17)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C190(0.66); C400(0.79); C408(0.79); C561(1.50)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C190(0.54); C400(1.02); C408(1.02); C561(1.18)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C737(1.16)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C737(1.04)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C737(1.00)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C737(1.39)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C400(0.75); C408(0.75); C737(0.95)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C400(0.67); C408(0.67); C737(1.12)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C737(1.07); C400(1.09); C408(1.09)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C737(1.02)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C400(0.84); C408(0.84); C737(1.27)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C400(0.79); C408(0.79); C737(1.13)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C737(0.96); C400(1.06); C408(1.06)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C737(0.93); C400(1.28); C408(1.28)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C400(0.70); C408(0.70); C737(1.29)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C400(0.65); C408(0.65); C737(1.03)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C400(0.75); C408(0.75); C737(1.30)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C400(0.80); C408(0.80); C737(1.26)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C400(0.67); C408(0.67); C737(1.18)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C400(1.09); C408(1.09); C737(1.14)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C737(1.06)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C400(0.49); C408(0.49); C737(1.09)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C400(0.80); C408(0.80); C737(1.21)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C737(0.97)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C737(1.00)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C737(1.18)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C737(0.85)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C737(0.95)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C737(0.85)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C737(0.99)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C737(1.14)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C737(0.76)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C737(1.23)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C737(1.00)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C737(1.04)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C737(0.96)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C737(1.03)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C400(0.64); C408(0.64); C190(0.91); C561(0.96)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C400(0.63); C408(0.63); C190(1.16); C561(0.69)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C400(0.80); C408(0.80); C190(0.83); C561(1.15)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C400(0.47); C408(0.47); C190(0.75); C561(0.76)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C737(0.88)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C400(0.67); C408(0.67); C190(0.67); C561(1.10)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C400(0.54); C408(0.54); C190(0.93); C561(1.04)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C400(0.77); C408(0.77); C190(0.96); C561(0.85)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C400(1.02); C408(1.02); C190(0.89); C561(0.89)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C400(0.71); C408(0.71); C190(0.76); C561(1.03)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C400(0.56); C408(0.56); C190(0.95); C561(1.09)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C400(0.61); C408(0.61); C190(0.86); C561(0.81)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C400(0.53); C408(0.53); C190(0.93); C561(1.00)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C400(0.47); C408(0.47); C190(0.97); C561(0.91)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C400(0.46); C408(0.46); C190(1.04); C561(1.06)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C737(1.05)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C400(0.54); C408(0.54); C190(0.92); C561(0.74)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C737(0.95)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C737(1.03)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C737(0.93)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C737(0.98)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C737(1.13)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C737(0.99)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C737(1.02)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C737(0.89)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C737(0.89)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C737(0.95)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C737(1.04)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C737(1.07)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C737(1.05)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C737(1.07)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C737(1.01)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C737(1.00)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C737(0.93)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C737(0.94)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C737(0.94)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C737(1.08)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C737(1.05)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C737(1.10)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C737(0.94)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C737(0.96)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C737(1.04)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C737(1.02)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C737(1.02)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C737(0.88)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C737(0.88)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C737(0.89)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C737(0.93)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C737(1.04)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C400(1.21); C408(1.21); C561(1.10); C737(0.95)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C400(1.19); C408(1.19); C561(0.97); C737(0.95)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C400(0.41); C408(0.41); C561(1.02); C737(0.95)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C400(0.62); C408(0.62); C561(0.85); C737(0.98)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C400(0.85); C408(0.85); C561(0.95); C737(0.94)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C400(0.63); C408(0.63); C561(1.15); C737(1.07)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C400(0.55); C408(0.55); C561(0.91); C737(1.04)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C400(0.85); C408(0.85); C561(1.03); C737(1.17)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C400(0.65); C408(0.65); C561(0.92); C737(1.02)  LDD0811  [5]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C449(2.40); C321(1.98); C346(1.41)  LDD1702  [3]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [4]
 LDCM0468  Fragment33 HCT 116 C737(1.09)  LDD0785  [5]
 LDCM0427  Fragment51 HCT 116 C737(0.62)  LDD0744  [5]
 LDCM0073  Kambe_cp3 PC-3 12.35  LDD0127  [10]
 LDCM0078  kambe_cp70 PC-3 20.00  LDD0134  [10]
 LDCM0022  KB02 42-MG-BA C233(2.26); C321(1.51)  LDD2244  [12]
 LDCM0023  KB03 MDA-MB-231 C449(2.59); C346(1.78); C737(0.58)  LDD1701  [3]
 LDCM0024  KB05 MEL182 C321(2.11)  LDD3317  [12]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C449(0.64)  LDD2100  [3]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C449(0.55)  LDD2128  [3]
 LDCM0021  THZ1 HCT 116 C430(1.43); C440(1.43)  LDD2173  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mast/stem cell growth factor receptor Kit (KIT) Tyr protein kinase family P10721
Receptor tyrosine-protein kinase erbB-2 (ERBB2) Tyr protein kinase family P04626
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-1 complex subunit mu-1 (AP1M1) Adaptor complexes medium subunit family Q9BXS5
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Breast cancer anti-estrogen resistance protein 1 (BCAR1) CAS family P56945
Enhancer of filamentation 1 (NEDD9) CAS family Q14511
Dynein regulatory complex subunit 4 (GAS8) DRC4 family O95995
Oxidative stress-induced growth inhibitor 1 (OSGIN1) OKL38 family Q9UJX0
RNA-binding protein FUS (FUS) RRM TET family P35637
Insulin receptor substrate 1 (IRS1) . P35568

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 Mapping the protein interaction landscape for fully functionalized small-molecule probes in human cells. J Am Chem Soc. 2014 Jul 30;136(30):10777-82. doi: 10.1021/ja505517t. Epub 2014 Jul 21.
11 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
12 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840