Details of the Target

General Information of Target

Target ID LDTP06295
Target Name Histone-lysine N-methyltransferase SETDB1 (SETDB1)
Gene Name SETDB1
Gene ID 9869
Synonyms
ESET; KIAA0067; KMT1E; Histone-lysine N-methyltransferase SETDB1; EC 2.1.1.366; ERG-associated protein with SET domain; ESET; Histone H3-K9 methyltransferase 4; H3-K9-HMTase 4; Lysine N-methyltransferase 1E; SET domain bifurcated 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQ
LAELETWVIQKESEVAHVDQLFDDASRAVTNCESLVKDFYSKLGLQYRDSSSEDESSRPT
EIIEIPDEDDDVLSIDSGDAGSRTPKDQKLREAMAALRKSAQDVQKFMDAVNKKSSSQDL
HKGTLSQMSGELSKDGDLIVSMRILGKKRTKTWHKGTLIAIQTVGPGKKYKVKFDNKGKS
LLSGNHIAYDYHPPADKLYVGSRVVAKYKDGNQVWLYAGIVAETPNVKNKLRFLIFFDDG
YASYVTQSELYPICRPLKKTWEDIEDISCRDFIEEYVTAYPNRPMVLLKSGQLIKTEWEG
TWWKSRVEEVDGSLVRILFLDDKRCEWIYRGSTRLEPMFSMKTSSASALEKKQGQLRTRP
NMGAVRSKGPVVQYTQDLTGTGTQFKPVEPPQPTAPPAPPFPPAPPLSPQAGDSDLESQL
AQSRKQVAKKSTSFRPGSVGSGHSSPTSPALSENVSGGKPGINQTYRSPLGSTASAPAPS
ALPAPPAPPVFHGMLERAPAEPSYRAPMEKLFYLPHVCSYTCLSRVRPMRNEQYRGKNPL
LVPLLYDFRRMTARRRVNRKMGFHVIYKTPCGLCLRTMQEIERYLFETGCDFLFLEMFCL
DPYVLVDRKFQPYKPFYYILDITYGKEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVFIN
TGPEFLVGCDCKDGCRDKSKCACHQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVYE
CNKRCKCDPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDD
FADKEGLEMGDEYFANLDHIESVENFKEGYESDAPCSSDSSGVDLKDQEDGNSGTEDPEE
SNDDSSDDNFCKDEDFSTSSVWRSYATRRQTRGQKENGLSETTSKDSHPPDLGPPHIPVP
PSIPVGGCNPPSSEETPKNKVASWLSCNSVSEGGFADSDSHSSFKTNEGGEGRAGGSRME
AEKASTSGLGIKDEGDIKQAKKEDTDDRNKMSVVTESSRNYGYNPSPVKPEGLRRPPSKT
SMHQSRRLMASAQSNPDDVLTLSSSTESEGESGTSRKPTAGQTSATAVDSDDIQTISSGS
EGDDFEDKKNMTGPMKRQVAVKSTRGFALKSTHGIAIKSTNMASVDKGESAPVRKNTRQF
YDGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGTE
LTWDYNYEVGSVEGKELLCCCGAIECRGRLL
Target Bioclass
Enzyme
Family
Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, Suvar3-9 subfamily
Subcellular location
Nucleus
Function
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Required for HUSH-mediated heterochromatin formation and gene silencing. Forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells. Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs). In ESCs, in collaboration with TRIM28, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway. Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing. The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions.
Uniprot ID
Q15047
Ensemble ID
ENST00000271640.9
HGNC ID
HGNC:10761
ChEMBL ID
CHEMBL2321646

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
Probe 1
 Probe Info  		Y564(12.30)  LDD3495  [2]
BTD
 Probe Info  		C819(1.29)  LDD2094  [3]
EA-probe
 Probe Info  		N.A.  LDD0440  [4]
DBIA
 Probe Info  		C92(1.04)  LDD0078  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C92(0.00); C53(0.00); C987(0.00); C819(0.00)  LDD0037  [6]
WYneN
 Probe Info  		N.A.  LDD0021  [7]
WYneO
 Probe Info  		N.A.  LDD0022  [7]
ENE
 Probe Info  		C53(0.00); C92(0.00)  LDD0006  [7]
IPM
 Probe Info  		C53(0.00); C92(0.00)  LDD0005  [7]
NHS
 Probe Info  		N.A.  LDD0010  [7]
TFBX
 Probe Info  		C53(0.00); C92(0.00)  LDD0148  [8]
VSF
 Probe Info  		N.A.  LDD0007  [7]
AOyne
 Probe Info  		13.00  LDD0443  [9]
NAIA_5
 Probe Info  		C1226(0.00); C7(0.00)  LDD2223  [10]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C177
 Probe Info  		8.17  LDD1856  [11]
C178
 Probe Info  		20.97  LDD1857  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C1280(0.81); C53(1.00); C1286(0.81); C329(0.91)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C1279(0.98); C1280(1.22); C53(1.04); C741(0.64)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C1279(0.75); C1280(0.75); C53(0.96); C1281(0.97)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C1279(1.19); C1280(1.19); C53(1.20); C1281(1.01)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C1279(1.21); C1280(1.21); C53(1.03); C1281(1.02)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C1279(1.28); C1280(1.28); C53(1.11); C1281(1.09)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C1279(1.31); C1280(1.31); C53(0.95); C1281(0.90)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C1279(1.10); C1280(1.10); C53(1.11); C1281(0.93)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C1279(1.56); C1280(1.56); C53(1.02); C1281(0.94)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C1279(1.58); C1280(1.58); C53(0.92); C1281(0.88)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C1279(0.91); C1280(0.91); C53(0.95); C1281(0.93)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C1279(0.83); C1280(0.83); C53(0.90); C1281(0.92)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C1279(1.06); C1280(1.47); C53(1.02); C741(0.68)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C1279(1.06); C1280(1.06); C53(0.92); C1281(0.99)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C1279(1.30); C1280(1.30); C53(0.93); C1281(1.05)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C1279(1.13); C1280(1.13); C53(0.89); C1281(1.02)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C1280(0.98); C53(1.10); C1286(0.98); C329(1.27)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C1280(0.78); C53(1.25); C1286(0.78); C329(0.96)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C1280(0.77); C53(1.22); C1286(0.77); C329(1.12)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C1280(1.03); C53(1.41); C1286(1.03); C329(1.00)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C1280(1.04); C53(1.20); C1286(1.04); C329(1.04)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C1280(1.05); C53(1.21); C1286(1.05); C329(1.14)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C1280(0.92); C53(1.25); C1286(0.92); C329(0.96)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C1279(1.33); C1280(1.26); C53(0.97); C741(0.71)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C1280(0.85); C53(1.10); C1286(0.85); C329(1.20)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C1280(0.76); C53(1.02); C1286(0.76); C329(0.92)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C1280(0.80); C53(1.32); C1286(0.80); C329(1.10)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C1280(0.74); C53(1.23); C1286(0.74); C329(0.91)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C1280(0.63); C53(1.11); C1286(0.63); C329(0.90)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C1280(0.97); C53(1.10); C1286(0.97); C329(1.10)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C1280(0.87); C53(1.41); C1286(0.87); C329(1.15)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C1280(0.77); C53(1.50); C1286(0.77); C329(0.96)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C1279(1.22); C1280(1.52); C53(1.18); C741(0.77)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C1279(0.77); C1280(0.59); C53(0.99); C741(1.45)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C1279(1.16); C1280(0.97); C53(1.23); C741(0.96)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C1279(0.71); C1280(0.69); C53(0.98); C741(1.03)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C1279(1.00); C1280(0.63); C53(1.16); C741(0.87)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C1279(1.03); C1280(0.92); C53(1.19); C741(1.01)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C1279(0.89); C1280(0.89); C53(1.05); C741(1.07)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C1279(1.11); C1280(0.99); C53(1.31); C741(0.82)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C1279(0.95); C1280(0.91); C53(1.30); C741(0.96)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C1279(0.92); C1280(0.74); C53(1.21); C741(0.96)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C1279(0.89); C1280(0.85); C53(1.13); C741(0.82)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C1279(1.36); C1280(0.92); C53(1.36); C741(0.75)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C1279(1.45); C1280(1.35); C53(0.85); C741(0.90)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C1279(1.19); C1280(0.84); C53(1.37); C741(0.80)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C1279(1.14); C1280(0.93); C53(1.20); C741(0.83)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C1279(0.86); C1280(0.69); C53(1.19); C741(1.10)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C1279(0.86); C1280(0.92); C53(1.60); C741(1.10)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C1280(0.80); C830(0.84); C1286(0.89); C631(0.93)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C1279(0.76); C741(0.77); C753(0.77); C1281(0.79)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C1280(0.87); C1286(0.87); C741(0.89); C753(0.89)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C830(0.81); C1279(0.82); C1281(0.83); C1286(0.84)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C1280(0.69); C830(0.73); C741(0.78); C753(0.78)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C631(0.83); C634(0.83); C830(0.88); C741(0.88)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C741(0.56); C743(0.56); C753(0.56); C729(0.59)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C631(0.79); C634(0.79); C1280(0.83); C1279(0.86)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C1280(0.80); C1286(0.80); C830(0.84); C1281(0.85)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C1281(0.74); C1279(0.76); C1286(0.76); C1280(0.79)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C743(0.68); C1280(0.71); C1279(0.73); C1286(0.73)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C1279(0.75); C1280(0.70); C53(1.34); C741(0.79)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C1279(0.97); C1280(0.79); C53(1.61); C741(1.06)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C1279(1.02); C1280(0.78); C53(1.18); C741(1.04)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C1279(0.83); C1280(0.67); C53(1.19); C741(0.96)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C787(0.75); C792(0.75); C631(0.91); C634(0.91)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C787(0.59); C792(0.59); C830(0.94); C53(1.00)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C631(0.73); C634(0.73); C830(0.87); C787(0.87)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C1280(0.95); C1286(0.95); C631(0.97); C634(0.97)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C631(0.60); C634(0.60); C830(0.89); C787(0.95)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C631(0.62); C634(0.62); C787(0.80); C792(0.80)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C830(0.92); C53(0.94); C787(0.95); C792(0.95)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C787(0.83); C792(0.83); C830(0.84); C53(0.86)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C631(0.84); C634(0.84); C787(0.93); C792(0.93)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C830(0.93); C631(0.94); C634(0.94); C329(0.97)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C631(0.83); C634(0.83); C830(0.84); C385(0.94)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C385(0.86); C631(0.88); C634(0.88); C830(0.96)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C787(0.75); C792(0.75); C385(0.76); C631(0.81)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C385(0.62); C631(0.70); C634(0.70); C329(0.91)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C1280(0.96); C1286(0.96); C329(1.01); C631(1.01)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C385(0.61); C631(0.74); C634(0.74); C787(0.90)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C385(0.87); C830(0.96); C329(1.07); C787(1.08)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C385(0.65); C631(0.75); C634(0.75); C830(0.85)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C631(0.85); C634(0.85); C830(0.89); C787(0.91)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C385(0.76); C787(0.80); C792(0.80); C631(0.89)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C787(0.81); C792(0.81); C329(0.93); C830(0.95)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C329(0.95); C830(0.99); C53(1.01); C787(1.03)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C53(0.81); C1286(0.97); C329(1.00); C1279(1.01)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C53(0.83); C329(0.97); C830(0.97); C1281(1.01)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C830(0.90); C329(0.98); C787(1.01); C792(1.01)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C631(0.97); C634(0.97); C329(1.02); C729(1.05)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C830(0.89); C53(0.95); C329(0.96); C1281(1.00)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C830(0.85); C53(0.96); C329(0.97); C1281(1.09)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C53(0.84); C830(0.87); C1281(0.96); C787(1.00)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C53(0.90); C830(0.91); C329(0.97); C1279(1.13)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C830(0.86); C1281(0.96); C329(1.00); C631(1.05)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C830(0.78); C631(0.92); C634(0.92); C1281(1.05)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C830(0.93); C787(1.18); C792(1.18); C329(1.19)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C830(0.83); C329(1.02); C787(1.12); C792(1.12)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C830(1.01); C53(1.14); C741(1.17); C743(1.17)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C830(0.79); C787(0.87); C792(0.87); C741(0.99)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C329(0.69); C729(0.94); C731(0.94); C1280(0.97)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C830(0.73); C741(0.99); C743(0.99); C753(0.99)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C830(0.95); C329(1.03); C53(1.17); C631(1.29)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C830(0.79); C741(0.98); C743(0.98); C753(0.98)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C830(0.85); C787(1.02); C792(1.02); C53(1.03)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C830(0.79); C787(0.85); C792(0.85); C329(0.92)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C830(0.86); C53(1.01); C329(1.05); C631(1.06)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C830(0.91); C631(1.11); C634(1.11); C741(1.15)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C741(0.53); C753(0.53); C787(0.91); C792(0.91)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C741(0.58); C753(0.58); C53(0.95); C773(0.98)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C741(0.41); C753(0.41); C631(0.80); C634(0.80)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C741(0.60); C743(0.60); C753(0.60); C729(0.62)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C741(0.63); C753(0.63); C830(0.85); C631(0.88)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C741(0.89); C753(0.89); C1281(0.91); C53(1.05)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C741(0.46); C753(0.46); C631(0.84); C634(0.84)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C741(0.54); C753(0.54); C631(0.84); C634(0.84)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C741(0.49); C753(0.49); C787(0.84); C792(0.84)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C741(0.41); C753(0.41); C830(0.81); C1281(0.92)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C741(0.49); C753(0.49); C787(0.85); C792(0.85)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C741(0.30); C753(0.30); C787(0.65); C792(0.65)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C743(0.85); C753(0.85); C741(0.88); C1281(0.89)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C53(0.92); C1281(0.94); C830(0.95); C1279(0.97)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C741(0.64); C743(0.64); C753(0.64); C729(0.73)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C830(0.75); C631(1.06); C634(1.06); C1281(1.07)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C1281(0.76); C53(0.80); C741(0.88); C743(0.91)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C830(0.90); C743(0.99); C753(0.99); C741(0.99)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C741(0.75); C743(0.77); C753(0.77); C830(0.78)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C741(0.80); C743(0.82); C753(0.82); C830(0.93)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C741(0.74); C743(0.75); C753(0.75); C830(0.86)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C741(0.80); C743(0.85); C753(0.85); C830(0.87)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C830(0.77); C1281(0.87); C1286(1.00); C1280(1.01)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C1281(0.85); C1286(0.93); C1280(0.95); C1279(0.98)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C741(0.71); C743(0.78); C753(0.78); C830(0.92)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C729(0.62); C731(0.62); C741(0.76); C743(0.76)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C743(0.90); C753(0.90); C741(0.90); C830(0.96)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C1281(0.82); C787(0.89); C792(0.89); C1286(0.99)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C741(0.63); C743(0.66); C753(0.66); C830(0.87)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C830(0.66); C787(0.67); C792(0.67); C773(0.74)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C787(0.61); C792(0.61); C743(0.69); C741(0.70)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C787(0.61); C792(0.61); C743(0.84); C741(0.88)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C743(0.64); C741(0.70); C753(0.70); C830(0.75)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C1281(0.73); C631(0.86); C634(0.86); C787(0.86)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C631(0.77); C634(0.77); C787(0.77); C792(0.77)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C743(0.56); C631(0.72); C634(0.72); C787(0.73)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C631(0.75); C634(0.75); C1281(0.88); C1279(0.92)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C830(0.62); C741(0.71); C753(0.71); C773(0.73)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C743(0.66); C830(0.68); C741(0.69); C753(0.69)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C787(0.63); C792(0.63); C743(0.64); C741(0.64)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C787(0.58); C792(0.58); C830(0.88); C743(0.92)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C1281(0.79); C1279(0.89); C1286(0.98); C1280(1.08)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C773(0.73); C781(0.73); C830(0.77); C741(0.89)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C787(0.62); C792(0.62); C631(0.70); C634(0.70)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C787(0.47); C792(0.47); C631(0.49); C634(0.49)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C787(0.50); C792(0.50); C631(0.70); C634(0.70)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C1279(1.05); C1280(1.11); C53(1.00); C741(0.65)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C729(0.61); C731(0.61); C741(0.63); C743(0.63)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C741(0.51); C743(0.51); C753(0.51); C729(0.60)  LDD0592  [5]
 LDCM0156  Aniline NCI-H1299 11.53  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C92(1.04)  LDD0078  [5]
 LDCM0632  CL-Sc Hep-G2 C92(1.24); C53(0.67); C92(0.58)  LDD2227  [10]
 LDCM0367  CL1 HCT 116 C329(0.80); C1280(0.84); C1286(0.84); C729(0.88)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C329(0.81); C729(0.91); C731(0.91); C1280(0.93)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C729(0.86); C731(0.86); C631(0.97); C634(0.97)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C729(0.55); C731(0.55); C741(0.56); C743(0.56)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C729(0.55); C731(0.55); C741(0.62); C743(0.62)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C729(0.62); C731(0.62); C741(0.66); C743(0.66)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C729(0.64); C731(0.64); C329(0.78); C830(0.93)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C631(0.68); C634(0.68); C787(0.72); C792(0.72)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C787(0.79); C792(0.79); C53(0.89); C830(0.95)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C631(0.67); C634(0.67); C787(0.77); C792(0.77)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C631(0.61); C634(0.61); C787(0.62); C792(0.62)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C787(0.77); C792(0.77); C830(0.86); C53(0.92)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C329(0.65); C1280(0.87); C1286(0.87); C830(0.89)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C631(0.70); C634(0.70); C830(0.82); C787(0.84)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C631(0.63); C634(0.63); C787(0.63); C792(0.63)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C385(0.71); C631(0.76); C634(0.76); C787(0.81)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C385(0.57); C631(0.70); C634(0.70); C787(0.80)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C385(0.51); C631(0.75); C634(0.75); C830(0.84)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C385(0.58); C787(0.76); C792(0.76); C631(0.81)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C631(0.80); C634(0.80); C830(0.89); C385(0.90)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C830(0.72); C631(0.86); C634(0.86); C329(0.97)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C830(0.90); C787(0.98); C792(0.98); C329(1.01)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C830(0.88); C53(0.92); C329(0.94); C1279(1.07)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C329(0.74); C1280(0.80); C1286(0.80); C830(0.82)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C830(0.88); C53(0.90); C329(0.98); C1279(1.09)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C329(0.84); C830(0.92); C631(1.03); C634(1.03)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C830(0.88); C741(0.97); C743(0.97); C753(0.97)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C830(0.79); C787(0.83); C792(0.83); C329(0.85)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C830(0.75); C741(0.75); C743(0.75); C753(0.75)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C741(0.56); C753(0.56); C787(0.83); C792(0.83)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C830(0.70); C787(0.76); C792(0.76); C1281(0.83)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C741(0.40); C753(0.40); C830(0.78); C787(0.78)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C741(0.36); C753(0.36); C830(0.87); C631(0.94)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C329(0.83); C1280(0.93); C1286(0.93); C53(1.01)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C329(0.84); C830(0.85); C729(0.90); C731(0.90)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C1280(0.77); C1286(0.77); C329(0.94); C830(0.96)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C329(0.82); C787(0.86); C792(0.86); C53(0.87)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C1281(0.80); C385(0.81); C787(0.83); C792(0.83)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C53(0.81); C773(0.84); C781(0.84); C329(0.85)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C773(0.80); C781(0.80); C53(0.81); C385(0.92)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C1280(0.75); C1286(0.75); C329(0.79); C53(0.95)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C773(0.65); C781(0.65); C631(0.77); C634(0.77)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C773(0.57); C781(0.57); C631(0.72); C634(0.72)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C631(0.61); C634(0.61); C773(0.64); C781(0.64)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C773(0.68); C781(0.68); C631(0.74); C634(0.74)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C53(0.99); C1279(1.37); C1280(1.43); C1281(0.99)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C1279(1.97); C1280(2.04); C53(1.12); C1281(1.14)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C1279(1.26); C1280(1.40); C53(0.87); C1281(1.51)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C1279(1.04); C1280(1.11); C53(0.91); C1281(1.06)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C1279(1.58); C1280(1.62); C53(0.94); C1281(1.31)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C1279(1.35); C1280(1.41); C53(0.92); C1281(1.01)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C1280(0.70); C53(1.11); C1286(0.70); C329(0.89)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C1279(0.88); C1280(0.91); C53(0.99); C1281(1.01)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C1279(1.17); C1280(1.17); C53(1.25); C1286(1.17)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C1279(1.09); C53(1.10); C1281(1.09); C1286(1.09)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C1279(1.23); C53(1.53); C1281(1.23); C1286(1.23)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C1279(1.34); C53(1.31); C1281(1.34); C1286(1.34)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C1279(1.21); C53(1.26); C1281(1.21); C1286(1.21)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C1279(1.05); C53(2.27); C1281(1.05); C1286(1.05)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C1279(1.06); C53(1.47); C1281(1.06); C1286(1.06)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C1279(0.95); C53(1.20); C1281(0.95); C1286(0.95)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C1280(1.03); C53(1.37); C1286(1.03); C329(0.71)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C1279(1.15); C53(2.13); C1281(1.15); C1286(1.15)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C1279(0.98); C53(1.49); C1281(0.98); C1286(0.98)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C1279(0.90); C53(1.73); C1281(0.90); C1286(0.90)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C1279(1.03); C53(1.26); C1281(1.03); C1286(1.03)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C1279(1.17); C53(1.24); C1281(1.17); C1286(1.17)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C1279(1.07); C53(3.06); C1281(1.07); C1286(1.07)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C1279(0.98); C1280(1.10); C53(1.39); C1281(1.03)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C1279(0.92); C1280(1.11); C53(1.26); C1281(0.81)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C1279(1.16); C1280(1.13); C53(1.10); C1281(1.14)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C1279(0.98); C1280(1.10); C53(1.18); C1281(0.96)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C1280(0.97); C53(0.98); C1286(0.97); C329(1.15)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C1279(0.98); C1280(1.04); C53(1.25); C1281(0.92)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C1279(1.00); C1280(1.05); C53(1.61); C1281(0.95)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C1279(1.04); C1280(1.09); C53(1.65); C1281(1.04)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C1279(1.08); C1280(1.04); C53(1.77); C1281(1.16)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C1279(1.14); C1280(1.12); C53(1.29); C1281(0.93)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C1279(1.03); C1280(1.02); C53(1.05); C1281(1.07)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C1279(0.92); C1280(0.97); C53(1.08); C1281(0.90)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C1279(1.11); C1280(0.97); C53(1.11); C1281(1.03)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C1279(0.97); C1280(1.08); C53(1.55); C1281(1.00)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C1279(1.07); C1280(0.99); C53(1.23); C1281(1.00)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C1280(1.00); C53(1.14); C1286(1.00); C329(0.98)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C1279(0.96); C1280(0.99); C53(1.58); C1281(0.93)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C1279(0.89); C1280(0.98); C53(1.25); C741(1.27)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C1279(0.88); C1280(1.02); C53(1.07); C741(0.96)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C1279(1.15); C1280(0.97); C53(1.87); C741(0.87)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C1279(1.16); C1280(1.00); C53(1.17); C741(0.99)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C1279(0.93); C1280(0.95); C53(1.32); C741(1.23)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C1279(0.93); C1280(0.88); C53(1.04); C741(0.91)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C1279(1.19); C1280(0.83); C53(1.17); C741(1.42)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C1279(0.88); C1280(0.80); C53(0.88); C741(1.13)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C1279(1.07); C1280(0.86); C53(1.26); C741(1.25)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C1280(1.02); C53(1.13); C1286(1.02); C329(1.03)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C1279(0.98); C1280(0.88); C53(1.16); C741(1.19)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C1279(0.89); C1280(0.89); C53(1.35); C741(0.86)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C1279(1.04); C1280(0.96); C53(1.45); C741(1.07)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C1279(1.03); C1280(0.80); C53(1.43); C741(0.68)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C1279(1.13); C1280(0.83); C53(1.38); C741(1.09)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C1280(1.01); C53(0.95); C1281(0.83); C1286(1.01)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C1280(0.98); C53(1.34); C1281(0.98); C1286(0.98)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C1280(1.06); C53(1.35); C1281(0.97); C1286(1.06)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C1280(1.04); C53(0.88); C1281(0.95); C1286(1.04)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C1280(0.87); C53(1.60); C1286(0.87); C329(0.94)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C1280(1.02); C53(0.93); C1281(1.01); C1286(1.02)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C1280(1.16); C53(0.84); C1281(1.13); C1286(1.16)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C1280(1.09); C53(0.97); C1281(1.11); C1286(1.09)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C1280(1.02); C53(1.10); C1281(0.96); C1286(1.02)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C1280(1.07); C53(1.31); C1281(1.17); C1286(1.07)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C1280(1.05); C53(1.21); C1281(0.88); C1286(1.05)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C1280(1.02); C53(1.03); C1281(0.93); C1286(1.02)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C1280(1.08); C53(0.82); C1281(1.30); C1286(1.08)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C1280(1.01); C53(1.05); C1281(0.86); C1286(1.01)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C1280(1.00); C53(0.93); C1281(0.91); C1286(1.00)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C1280(0.87); C53(1.01); C1286(0.87); C329(0.93)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C1280(1.01); C53(1.05); C1281(1.13); C1286(1.01)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C1280(0.97); C53(1.11); C1286(0.97); C329(1.22)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C1280(0.93); C53(1.21); C1286(0.93); C329(0.99)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C1280(1.10); C53(1.19); C1286(1.10); C329(0.94)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C1280(0.96); C53(1.32); C1286(0.96); C329(0.95)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C1280(0.72); C53(1.59); C1286(0.72); C329(1.00)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C1280(0.83); C53(1.41); C1286(0.83); C329(1.07)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C1280(0.95); C53(1.28); C1286(0.95); C329(0.84)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C1280(0.87); C53(1.26); C1286(0.87); C329(1.11)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C1280(1.44); C53(1.18); C1286(1.44); C329(1.03)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C1226(1.00); C830(1.11); C385(0.91); C819(0.94)  LDD1698  [12]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C819(0.91)  LDD1702  [3]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [4]
 LDCM0468  Fragment33 HCT 116 C1279(0.97); C1280(1.04); C53(1.22); C741(1.23)  LDD0785  [5]
 LDCM0427  Fragment51 HCT 116 C1279(1.18); C53(6.76); C1281(1.18); C1286(1.18)  LDD0744  [5]
 LDCM0022  KB02 HCT 116 C1279(2.07); C1286(2.07); C1281(2.07); C385(1.24)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C1279(1.58); C1286(1.58); C1281(1.58); C385(1.13)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C1279(1.80); C1286(1.80); C1281(1.80); C385(1.56)  LDD0082  [5]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C819(1.29)  LDD2094  [3]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C819(1.68)  LDD2153  [3]
 LDCM0628  OTUB2-COV-1 HEK-293T C53(0.35)  LDD2207  [13]
 LDCM0021  THZ1 HCT 116 C1279(1.03); C1286(1.03); C53(1.19); C1281(0.91)  LDD2173  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 23 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5-hydroxymethyl-dUMP N-hydrolase (DNPH1) 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family O43598
Bile acid-CoA:amino acid N-acyltransferase (BAAT) C/M/P thioester hydrolase family Q14032
Pantetheine hydrolase VNN2 (VNN2) BTD/VNN family O95498
DNA (cytosine-5)-methyltransferase 3A (DNMT3A) C5-methyltransferase family Q9Y6K1
Thiopurine S-methyltransferase (TPMT) TPMT family P51580
NADH dehydrogenase flavoprotein 1, mitochondrial (NDUFV1) Complex I 51 kDa subunit family P49821
NADH dehydrogenase 1 alpha subcomplex subunit 5 (NDUFA5) Complex I NDUFA5 subunit family Q16718
Palmitoyltransferase ZDHHC17 (ZDHHC17) DHHC palmitoyltransferase family Q8IUH5
DNA polymerase iota (POLI) DNA polymerase type-Y family Q9UNA4
Lipoyl amidotransferase LIPT1, mitochondrial (LIPT1) LplA family Q9Y234
Thiol S-methyltransferase TMT1A (TMT1A) Methyltransferase superfamily Q9H8H3
Cathepsin O (CTSO) Peptidase C1 family P43234
Ubiquitin carboxyl-terminal hydrolase 38 (USP38) Peptidase C19 family Q8NB14
Carboxypeptidase N catalytic chain (CPN1) Peptidase M14 family P15169
E3 SUMO-protein ligase PIAS3 (PIAS3) PIAS family Q9Y6X2
RAC-alpha serine/threonine-protein kinase (AKT1) AGC Ser/Thr protein kinase family P31749
Mitogen-activated protein kinase 11 (MAPK11) CMGC Ser/Thr protein kinase family Q15759
Mitogen-activated protein kinase kinase kinase 9 (MAP3K9) STE Ser/Thr protein kinase family P80192
Rho-related BTB domain-containing protein 1 (RHOBTB1) Rho family O94844
Acyl-coenzyme A thioesterase 13 (ACOT13) Thioesterase PaaI family Q9NPJ3
Septin-6 (SEPTIN6) Septin GTPase family Q14141
E3 ubiquitin-protein ligase RNF114 (RNF114) . Q9Y508
Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase (PIP4P1) . Q86T03
Transporter and channel
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
PAT complex subunit CCDC47 (CCDC47) CCDC47 family Q96A33
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial (SDHC) Cytochrome b560 family Q99643
Huntingtin (HTT) Huntingtin family P42858
Sorting nexin-10 (SNX10) Sorting nexin family Q9Y5X0
Sorting nexin-33 (SNX33) Sorting nexin family Q8WV41
Vesicle-associated membrane protein 3 (VAMP3) Synaptobrevin family Q15836
Transmembrane protein 176B (TMEM176B) TMEM176 family Q3YBM2
Calcium and integrin-binding protein 1 (CIB1) . Q99828
Stromal interaction molecule 1 (STIM1) . Q13586
Transcription factor
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-B13 (HOXB13) Abd-B homeobox family Q92826
Homeobox protein Hox-C4 (HOXC4) Antp homeobox family P09017
Transcription factor AP-2-beta (TFAP2B) AP-2 family Q92481
G-protein coupled receptor-associated sorting protein 2 (GPRASP2) GPRASP family Q96D09
Zinc finger and SCAN domain-containing protein 9 (ZSCAN9) Krueppel C2H2-type zinc-finger protein family O15535
Zinc finger protein with KRAB and SCAN domains 8 (ZKSCAN8) Krueppel C2H2-type zinc-finger protein family Q15776
Krueppel-like factor 12 (KLF12) Sp1 C2H2-type zinc-finger protein family Q9Y4X4
DNA-binding protein inhibitor ID-2 (ID2) . Q02363
LIM/homeobox protein Lhx5 (LHX5) . Q9H2C1
Methyl-CpG-binding domain protein 1 (MBD1) . Q9UIS9
Myeloid cell nuclear differentiation antigen (MNDA) . P41218
Transcription factor 4 (TCF4) . P15884
Transcription factor SOX-10 (SOX10) . P56693
Zinc finger MYM-type protein 3 (ZMYM3) . Q14202
GPCR
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
D(1A) dopamine receptor (DRD1) G-protein coupled receptor 1 family P21728
Probable G-protein coupled receptor 160 (GPR160) G-protein coupled receptor 1 family Q9UJ42
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Interleukin-3 receptor subunit alpha (IL3RA) Type I cytokine receptor family P26951
Other
Click To Hide/Show 40 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ankyrin repeat and SOCS box protein 1 (ASB1) Ankyrin SOCS box (ASB) family Q9Y576
B melanoma antigen 1 (BAGE) BAGE family Q13072
Coiled-coil domain-containing protein 90B, mitochondrial (CCDC90B) CCDC90 family Q9GZT6
Parafibromin (CDC73) CDC73 family Q6P1J9
Centrosomal protein of 76 kDa (CEP76) CEP76 family Q8TAP6
Dexamethasone-induced protein (DEXI) DEXI family O95424
Eukaryotic translation initiation factor 3 subunit E (EIF3E) EIF-3 subunit E family P60228
Protein pelota homolog (PELO) Eukaryotic release factor 1 family Q9BRX2
Large ribosomal subunit protein eL33 (RPL35A) Eukaryotic ribosomal protein eL33 family P18077
Fascin-2 (FSCN2) Fascin family O14926
Guanine nucleotide-binding protein subunit alpha-14 (GNA14) G-alpha family O95837
Centromere protein V (CENPV) Gfa family Q7Z7K6
HCLS1-associated protein X-1 (HAX1) HAX1 family O00165
Histone H4 (H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16) Histone H4 family P62805
Immunoglobulin-binding protein 1 (IGBP1) IGBP1/TAP42 family P78318
Keratin-associated protein 3-1 (KRTAP3-1) KRTAP type 3 family Q9BYR8
MICOS complex subunit MIC19 (CHCHD3) MICOS complex subunit Mic19 family Q9NX63
Lumican (LUM) Small leucine-rich proteoglycan (SLRP) family P51884
SNW domain-containing protein 1 (SNW1) SNW family Q13573
Synaptogyrin-3 (SYNGR3) Synaptogyrin family O43761
Transmembrane protein 54 (TMEM54) TMEM54 family Q969K7
Translin-associated protein X (TSNAX) Translin family Q99598
tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 (TRMT6) TRM6/GCD10 family Q9UJA5
Macrophage immunometabolism regulator (MACIR) UNC119-binding protein family Q96GV9
UPF0547 protein C16orf87 (C16orf87) UPF0547 family Q6PH81
Thyroid receptor-interacting protein 6 (TRIP6) Zyxin/ajuba family Q15654
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 (ACAP1) . Q15027
BTB/POZ domain-containing protein KCTD17 (KCTD17) . Q8N5Z5
Heat shock factor 2-binding protein (HSF2BP) . O75031
Heterogeneous nuclear ribonucleoprotein F (HNRNPF) . P52597
Insulin-like growth factor-binding protein 3 (IGFBP3) . P17936
M-phase phosphoprotein 8 (MPHOSPH8) . Q99549
Melanoma-associated antigen H1 (MAGEH1) . Q9H213
Programmed cell death protein 2 (PDCD2) . Q16342
RCC1-like G exchanging factor-like protein (RCC1L) . Q96I51
Regulating synaptic membrane exocytosis protein 3 (RIMS3) . Q9UJD0
Rho guanine nucleotide exchange factor 9 (ARHGEF9) . O43307
Vitamin K-dependent protein S (PROS1) . P07225
Zinc finger FYVE domain-containing protein 21 (ZFYVE21) . Q9BQ24
Zinc finger protein 346 (ZNF346) . Q9UL40

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.