Details of the Target

General Information of Target

Target ID LDTP14133
Target Name Transportin-3 (TNPO3)
Gene Name TNPO3
Gene ID 23534
Synonyms
IPO12; Transportin-3; Importin-12; Imp12; Transportin-SR; TRN-SR
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSGKDRIEIFPSRMAQTIMKARLKGAQTGRNLLKKKSDALTLRFRQILKKIIETKMLMGE
VMREAAFSLAEAKFTAGDFSTTVIQNVNKAQVKIRAKKDNVAGVTLPVFEHYHEGTDSYE
LTGLARGGEQLAKLKRNYAKAVELLVELASLQTSFVTLDEAIKITNRRVNAIEHVIIPRI
ERTLAYIITELDEREREEFYRLKKIQEKKKILKEKSEKDLEQRRAAGEVLEPANLLAEEK
DEDLLFE
Target Bioclass
Transporter and channel
Subcellular location
Nucleus envelope
Function
Importin, which transports target proteins into the nucleus. Specifically mediates the nuclear import of splicing factor serine/arginine (SR) proteins, such as RBM4, SFRS1 and SFRS2, by recognizing phosphorylated SR domains. Also mediates the nuclear import of serine/arginine (SR) protein CPSF6, independently of CPSF6 phosphorylation. The nuclear import process is regulated by the small GTPase Ran that partitions between cytoplasm and nucleus in the predominantly GDP- and GTP-bound form, respectively. Importin associates with target cargo proteins in the cytoplasm, and the competitive binding of GTP-bound Ran induces the release of cargos in the nucleus.; (Microbial infection) Involved in immunodeficiency virus (HIV-1) infection by importing the pre-integration complex (PIC) into the nucleus. Required for a nuclear maturation step of HIV-1 prior to integration.
Uniprot ID
Q9Y5L0
Ensemble ID
ENST00000265388.10
HGNC ID
HGNC:17103

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 27 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		9.74  LDD0402  [1]
A-EBA
 Probe Info  		4.40  LDD0215  [2]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [3]
BTD
 Probe Info  		C793(1.29)  LDD1700  [4]
AHL-Pu-1
 Probe Info  		C125(2.04)  LDD0168  [5]
EA-probe
 Probe Info  		N.A.  LDD0440  [6]
DBIA
 Probe Info  		C908(5.10); C793(8.47); C912(10.83)  LDD0209  [7]
ATP probe
 Probe Info  		N.A.  LDD0199  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C793(0.00); C125(0.00); C511(0.00); C380(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		C793(0.00); C634(0.00); C511(0.00)  LDD0032  [10]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [11]
Lodoacetamide azide
 Probe Info  		C527(0.00); C530(0.00); C793(0.00); C125(0.00)  LDD0037  [9]
TFBX
 Probe Info  		C60(0.00); C511(0.00); C634(0.00)  LDD0027  [12]
WYneN
 Probe Info  		C634(0.00); C793(0.00)  LDD0021  [13]
WYneO
 Probe Info  		C511(0.00); C793(0.00)  LDD0022  [13]
Compound 10
 Probe Info  		C634(0.00); C793(0.00); C912(0.00)  LDD2216  [14]
ENE
 Probe Info  		C793(0.00); C908(0.00); C312(0.00)  LDD0006  [13]
IPM
 Probe Info  		C634(0.00); C312(0.00); C530(0.00); C793(0.00)  LDD0005  [13]
PPMS
 Probe Info  		N.A.  LDD0008  [13]
STPyne
 Probe Info  		N.A.  LDD0009  [13]
VSF
 Probe Info  		C793(0.00); C511(0.00)  LDD0007  [13]
1c-yne
 Probe Info  		K27(0.00); K5(0.00)  LDD0228  [15]
Acrolein
 Probe Info  		C511(0.00); C312(0.00)  LDD0217  [16]
Methacrolein
 Probe Info  		C312(0.00); C908(0.00)  LDD0218  [16]
W1
 Probe Info  		C908(0.00); C312(0.00)  LDD0236  [17]
AOyne
 Probe Info  		14.40  LDD0443  [18]
NAIA_5
 Probe Info  		C908(0.00); C511(0.00); C634(0.00); C912(0.00)  LDD2223  [19]
PAL-AfBPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		5.65  LDD0471  [20]
FFF probe13
 Probe Info  		12.13  LDD0475  [20]
FFF probe14
 Probe Info  		20.00  LDD0477  [20]
FFF probe3
 Probe Info  		5.95  LDD0465  [20]
JN0003
 Probe Info  		20.00  LDD0469  [20]
STS-1
 Probe Info  		1.00  LDD0137  [21]
STS-2
 Probe Info  		N.A.  LDD0138  [21]
OEA-DA
 Probe Info  		8.04  LDD0046  [22]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C511(0.61)  LDD2095  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C511(0.86); C793(1.18); C908(0.99); C312(0.75)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C511(1.20); C527(0.95)  LDD2152  [4]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C511(1.07)  LDD2103  [4]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C511(0.66)  LDD2132  [4]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C511(0.70); C793(0.72)  LDD2131  [4]
 LDCM0025  4SU-RNA HEK-293T C125(2.04)  LDD0168  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C125(2.48); C511(2.02); C312(2.71)  LDD0169  [5]
 LDCM0214  AC1 HEK-293T C793(1.03); C634(0.98); C908(1.11); C380(1.09)  LDD1507  [23]
 LDCM0215  AC10 HEK-293T C793(1.06); C634(0.96); C908(0.96); C380(0.98)  LDD1508  [23]
 LDCM0226  AC11 HEK-293T C793(1.03); C634(1.01); C908(0.96); C380(0.98)  LDD1509  [23]
 LDCM0237  AC12 HEK-293T C793(0.99); C634(1.00); C908(1.03); C380(1.08)  LDD1510  [23]
 LDCM0259  AC14 HEK-293T C793(1.03); C634(0.94); C908(0.94); C380(1.04)  LDD1512  [23]
 LDCM0270  AC15 HEK-293T C793(1.06); C634(0.94); C908(0.93); C380(0.97)  LDD1513  [23]
 LDCM0276  AC17 HEK-293T C793(1.03); C634(1.02); C908(0.95); C380(1.11)  LDD1515  [23]
 LDCM0277  AC18 HEK-293T C793(1.02); C634(0.90); C908(0.95); C380(1.04)  LDD1516  [23]
 LDCM0278  AC19 HEK-293T C793(1.12); C634(1.84); C908(2.01); C380(1.10)  LDD1517  [23]
 LDCM0279  AC2 HEK-293T C793(1.01); C634(1.07); C908(0.88); C380(1.07)  LDD1518  [23]
 LDCM0280  AC20 HEK-293T C793(0.97); C634(1.00); C908(1.03); C380(1.00)  LDD1519  [23]
 LDCM0281  AC21 HEK-293T C793(1.01); C634(1.00); C908(1.00); C380(1.06)  LDD1520  [23]
 LDCM0282  AC22 HEK-293T C793(1.03); C634(1.13); C908(0.96); C380(1.03)  LDD1521  [23]
 LDCM0283  AC23 HEK-293T C793(0.99); C634(0.89); C908(0.95); C380(1.05)  LDD1522  [23]
 LDCM0284  AC24 HEK-293T C793(1.00); C634(0.92); C908(1.01); C380(1.12)  LDD1523  [23]
 LDCM0285  AC25 HEK-293T C793(1.02); C634(0.99); C908(1.00); C380(1.07)  LDD1524  [23]
 LDCM0286  AC26 HEK-293T C793(1.00); C634(0.97); C908(0.99); C380(0.85)  LDD1525  [23]
 LDCM0287  AC27 HEK-293T C793(1.00); C634(0.99); C908(1.02); C380(0.97)  LDD1526  [23]
 LDCM0288  AC28 HEK-293T C793(1.01); C634(1.08); C908(1.01); C380(1.03)  LDD1527  [23]
 LDCM0289  AC29 HEK-293T C793(0.99); C634(1.00); C908(0.99); C380(1.07)  LDD1528  [23]
 LDCM0290  AC3 HEK-293T C793(1.00); C634(0.97); C908(0.95); C380(1.08)  LDD1529  [23]
 LDCM0291  AC30 HEK-293T C793(1.02); C634(0.91); C908(0.91); C380(1.11)  LDD1530  [23]
 LDCM0292  AC31 HEK-293T C793(1.05); C634(0.93); C908(0.96); C380(0.98)  LDD1531  [23]
 LDCM0293  AC32 HEK-293T C793(0.97); C634(1.01); C908(0.98); C380(1.01)  LDD1532  [23]
 LDCM0294  AC33 HEK-293T C793(1.03); C634(0.91); C908(1.01); C380(1.10)  LDD1533  [23]
 LDCM0295  AC34 HEK-293T C793(1.03); C634(0.97); C908(0.96); C380(0.90)  LDD1534  [23]
 LDCM0296  AC35 HEK-293T C793(1.02); C634(0.98); C908(0.90); C380(0.93)  LDD1535  [23]
 LDCM0297  AC36 HEK-293T C793(0.97); C634(0.99); C908(0.97); C380(1.08)  LDD1536  [23]
 LDCM0298  AC37 HEK-293T C793(0.94); C634(1.00); C908(1.10); C380(1.06)  LDD1537  [23]
 LDCM0299  AC38 HEK-293T C793(0.98); C634(0.85); C908(0.88); C380(1.09)  LDD1538  [23]
 LDCM0300  AC39 HEK-293T C793(1.00); C634(0.83); C908(0.88); C380(1.00)  LDD1539  [23]
 LDCM0301  AC4 HEK-293T C793(0.99); C634(1.00); C908(0.99); C380(1.09)  LDD1540  [23]
 LDCM0302  AC40 HEK-293T C793(1.12); C634(1.09); C908(0.95); C380(1.11)  LDD1541  [23]
 LDCM0303  AC41 HEK-293T C793(1.03); C634(0.89); C908(1.01); C380(1.00)  LDD1542  [23]
 LDCM0304  AC42 HEK-293T C793(1.04); C634(1.08); C908(0.89); C380(0.90)  LDD1543  [23]
 LDCM0305  AC43 HEK-293T C793(1.07); C634(0.94); C908(0.91); C380(0.95)  LDD1544  [23]
 LDCM0306  AC44 HEK-293T C793(1.00); C634(0.86); C908(0.98); C380(0.95)  LDD1545  [23]
 LDCM0307  AC45 HEK-293T C793(1.01); C634(1.09); C908(0.96); C380(0.97)  LDD1546  [23]
 LDCM0308  AC46 HEK-293T C793(0.98); C634(1.03); C908(0.91); C380(1.00)  LDD1547  [23]
 LDCM0309  AC47 HEK-293T C793(1.05); C634(0.97); C908(0.90); C380(0.95)  LDD1548  [23]
 LDCM0310  AC48 HEK-293T C793(1.00); C634(1.04); C908(0.94); C380(1.01)  LDD1549  [23]
 LDCM0311  AC49 HEK-293T C793(1.00); C634(0.95); C908(1.10); C380(1.08)  LDD1550  [23]
 LDCM0312  AC5 HEK-293T C793(0.99); C634(1.01); C908(1.01); C380(1.06)  LDD1551  [23]
 LDCM0313  AC50 HEK-293T C793(1.01); C634(1.06); C908(0.92); C380(0.88)  LDD1552  [23]
 LDCM0314  AC51 HEK-293T C793(0.99); C634(0.99); C908(0.90); C380(1.01)  LDD1553  [23]
 LDCM0315  AC52 HEK-293T C793(1.01); C634(0.95); C908(0.96); C380(1.09)  LDD1554  [23]
 LDCM0316  AC53 HEK-293T C793(1.01); C634(1.04); C908(1.11); C380(1.05)  LDD1555  [23]
 LDCM0317  AC54 HEK-293T C793(1.05); C634(0.97); C908(0.93); C380(1.02)  LDD1556  [23]
 LDCM0318  AC55 HEK-293T C793(0.99); C634(0.90); C908(0.92); C380(1.03)  LDD1557  [23]
 LDCM0319  AC56 HEK-293T C793(1.01); C634(1.03); C908(0.96); C380(1.00)  LDD1558  [23]
 LDCM0320  AC57 HEK-293T C793(1.10); C634(0.99); C908(1.08); C380(0.98)  LDD1559  [23]
 LDCM0321  AC58 HEK-293T C793(1.01); C634(1.04); C908(0.98); C380(0.95)  LDD1560  [23]
 LDCM0322  AC59 HEK-293T C793(1.03); C634(0.97); C908(0.96); C380(0.91)  LDD1561  [23]
 LDCM0323  AC6 HEK-293T C793(0.98); C634(1.06); C908(0.94); C380(1.10)  LDD1562  [23]
 LDCM0324  AC60 HEK-293T C793(1.01); C634(0.94); C908(1.07); C380(1.05)  LDD1563  [23]
 LDCM0325  AC61 HEK-293T C793(1.00); C634(1.14); C908(1.21); C380(1.02)  LDD1564  [23]
 LDCM0326  AC62 HEK-293T C793(0.96); C634(0.89); C908(0.98); C380(1.03)  LDD1565  [23]
 LDCM0327  AC63 HEK-293T C793(1.03); C634(1.00); C908(0.95); C380(0.93)  LDD1566  [23]
 LDCM0328  AC64 HEK-293T C793(0.99); C634(1.00); C908(0.95); C380(1.09)  LDD1567  [23]
 LDCM0334  AC7 HEK-293T C793(1.00); C634(0.89); C908(0.91); C380(1.01)  LDD1568  [23]
 LDCM0345  AC8 HEK-293T C793(1.02); C634(1.05); C908(0.95); C380(1.12)  LDD1569  [23]
 LDCM0545  Acetamide MDA-MB-231 C511(0.39)  LDD2138  [4]
 LDCM0248  AKOS034007472 HEK-293T C793(1.04); C634(1.06); C908(1.08); C380(1.06)  LDD1511  [23]
 LDCM0356  AKOS034007680 HEK-293T C793(1.07); C634(0.92); C908(0.97); C380(1.02)  LDD1570  [23]
 LDCM0275  AKOS034007705 HEK-293T C793(1.04); C634(0.98); C908(0.98); C380(1.04)  LDD1514  [23]
 LDCM0156  Aniline NCI-H1299 11.42  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C634(0.48)  LDD2091  [4]
 LDCM0108  Chloroacetamide HeLa C511(0.00); C380(0.00); C303(0.00); C312(0.00)  LDD0222  [16]
 LDCM0632  CL-Sc Hep-G2 C511(2.35); C634(2.12)  LDD2227  [19]
 LDCM0367  CL1 HEK-293T C793(3.33); C634(1.24); C908(0.96); C380(1.14)  LDD1571  [23]
 LDCM0368  CL10 HEK-293T C793(6.71); C634(3.33); C908(1.41); C380(1.12)  LDD1572  [23]
 LDCM0369  CL100 HEK-293T C793(2.49); C634(1.13); C908(1.01); C380(0.99)  LDD1573  [23]
 LDCM0370  CL101 HEK-293T C793(1.43); C634(1.02); C908(0.93); C380(1.11)  LDD1574  [23]
 LDCM0371  CL102 HEK-293T C793(3.57); C634(1.29); C908(1.08); C380(1.02)  LDD1575  [23]
 LDCM0372  CL103 HEK-293T C793(1.15); C634(0.92); C908(1.02); C380(1.01)  LDD1576  [23]
 LDCM0373  CL104 HEK-293T C793(2.27); C634(1.07); C908(0.96); C380(0.98)  LDD1577  [23]
 LDCM0374  CL105 HEK-293T C793(2.09); C634(1.11); C908(0.98); C380(1.00)  LDD1578  [23]
 LDCM0375  CL106 HEK-293T C793(2.90); C634(1.15); C908(1.10); C380(0.89)  LDD1579  [23]
 LDCM0376  CL107 HEK-293T C793(1.03); C634(0.93); C908(0.82); C380(0.98)  LDD1580  [23]
 LDCM0377  CL108 HEK-293T C793(0.97); C634(1.03); C908(0.96); C380(0.97)  LDD1581  [23]
 LDCM0378  CL109 HEK-293T C793(3.08); C634(1.08); C908(0.97); C380(1.06)  LDD1582  [23]
 LDCM0379  CL11 HEK-293T C793(4.61); C634(1.10); C908(1.01); C380(1.12)  LDD1583  [23]
 LDCM0380  CL110 HEK-293T C793(4.82); C634(1.65); C908(0.99); C380(0.87)  LDD1584  [23]
 LDCM0381  CL111 HEK-293T C793(2.98); C634(1.07); C908(0.96); C380(1.06)  LDD1585  [23]
 LDCM0382  CL112 HEK-293T C793(1.58); C634(1.04); C908(0.99); C380(0.95)  LDD1586  [23]
 LDCM0383  CL113 HEK-293T C793(0.93); C634(0.96); C908(0.88); C380(0.97)  LDD1587  [23]
 LDCM0384  CL114 HEK-293T C793(4.65); C634(1.57); C908(1.10); C380(1.06)  LDD1588  [23]
 LDCM0385  CL115 HEK-293T C793(1.02); C634(0.92); C908(0.94); C380(0.95)  LDD1589  [23]
 LDCM0386  CL116 HEK-293T C793(0.99); C634(0.92); C908(0.96); C380(1.01)  LDD1590  [23]
 LDCM0387  CL117 HEK-293T C793(1.08); C634(0.96); C908(0.89); C380(1.07)  LDD1591  [23]
 LDCM0388  CL118 HEK-293T C793(1.00); C634(0.94); C908(0.97); C380(1.06)  LDD1592  [23]
 LDCM0389  CL119 HEK-293T C793(1.00); C634(0.94); C908(0.91); C380(0.99)  LDD1593  [23]
 LDCM0390  CL12 HEK-293T C793(2.42); C634(1.05); C908(1.08); C380(1.25)  LDD1594  [23]
 LDCM0391  CL120 HEK-293T C793(1.02); C634(0.87); C908(0.97); C380(0.92)  LDD1595  [23]
 LDCM0392  CL121 HEK-293T C793(1.28); C634(0.99); C908(0.94); C380(1.02)  LDD1596  [23]
 LDCM0393  CL122 HEK-293T C793(1.93); C634(1.11); C908(1.07); C380(1.02)  LDD1597  [23]
 LDCM0394  CL123 HEK-293T C793(4.57); C634(1.42); C908(1.20); C380(1.09)  LDD1598  [23]
 LDCM0395  CL124 HEK-293T C793(3.52); C634(1.30); C908(1.08); C380(1.03)  LDD1599  [23]
 LDCM0396  CL125 HEK-293T C793(1.04); C634(1.03); C908(1.02); C380(1.08)  LDD1600  [23]
 LDCM0397  CL126 HEK-293T C793(1.56); C634(1.06); C908(0.95); C380(0.97)  LDD1601  [23]
 LDCM0398  CL127 HEK-293T C793(1.08); C634(1.01); C908(0.90); C380(1.04)  LDD1602  [23]
 LDCM0399  CL128 HEK-293T C793(1.03); C634(0.94); C908(1.02); C380(0.99)  LDD1603  [23]
 LDCM0400  CL13 HEK-293T C793(1.28); C634(1.13); C908(0.96); C380(1.02)  LDD1604  [23]
 LDCM0401  CL14 HEK-293T C793(1.11); C634(0.98); C908(1.19); C380(1.05)  LDD1605  [23]
 LDCM0402  CL15 HEK-293T C793(5.24); C634(2.05); C908(1.45); C380(1.05)  LDD1606  [23]
 LDCM0403  CL16 HEK-293T C793(1.02); C634(1.02); C908(0.92); C380(1.01)  LDD1607  [23]
 LDCM0404  CL17 HEK-293T C793(5.17); C634(1.55); C908(1.72); C380(1.10)  LDD1608  [23]
 LDCM0405  CL18 HEK-293T C793(1.10); C634(0.98); C908(0.97); C380(0.97)  LDD1609  [23]
 LDCM0406  CL19 HEK-293T C793(1.13); C634(1.00); C908(0.94); C380(1.06)  LDD1610  [23]
 LDCM0407  CL2 HEK-293T C793(1.05); C634(1.01); C908(1.36); C380(0.92)  LDD1611  [23]
 LDCM0408  CL20 HEK-293T C793(1.08); C634(0.98); C908(1.04); C380(1.08)  LDD1612  [23]
 LDCM0409  CL21 HEK-293T C793(5.68); C634(1.98); C908(1.34); C380(1.18)  LDD1613  [23]
 LDCM0410  CL22 HEK-293T C793(1.35); C634(0.82); C908(0.93); C380(1.15)  LDD1614  [23]
 LDCM0411  CL23 HEK-293T C793(1.06); C634(0.97); C908(1.00); C380(1.16)  LDD1615  [23]
 LDCM0412  CL24 HEK-293T C793(1.39); C634(1.09); C908(1.05); C380(1.24)  LDD1616  [23]
 LDCM0413  CL25 HEK-293T C793(2.97); C634(1.41); C908(1.08); C380(0.96)  LDD1617  [23]
 LDCM0414  CL26 HEK-293T C793(1.13); C634(0.98); C908(1.07); C380(0.88)  LDD1618  [23]
 LDCM0415  CL27 HEK-293T C793(1.08); C634(0.95); C908(0.87); C380(1.05)  LDD1619  [23]
 LDCM0416  CL28 HEK-293T C793(2.19); C634(1.00); C908(0.99); C380(1.00)  LDD1620  [23]
 LDCM0417  CL29 HEK-293T C793(1.04); C634(0.98); C908(1.02); C380(1.00)  LDD1621  [23]
 LDCM0418  CL3 HEK-293T C793(2.19); C634(1.06); C908(1.11); C380(1.18)  LDD1622  [23]
 LDCM0419  CL30 HEK-293T C793(1.02); C634(0.96); C908(0.93); C380(1.01)  LDD1623  [23]
 LDCM0420  CL31 HEK-293T C793(1.43); C634(1.03); C908(1.01); C380(1.07)  LDD1624  [23]
 LDCM0421  CL32 HEK-293T C793(1.86); C634(0.99); C908(1.00); C380(1.00)  LDD1625  [23]
 LDCM0422  CL33 HEK-293T C793(5.12); C634(3.03); C908(1.59); C380(1.49)  LDD1626  [23]
 LDCM0423  CL34 HEK-293T C793(4.46); C634(1.00); C908(0.96); C380(1.11)  LDD1627  [23]
 LDCM0424  CL35 HEK-293T C793(1.08); C634(0.82); C908(0.96); C380(1.03)  LDD1628  [23]
 LDCM0425  CL36 HEK-293T C793(2.41); C634(1.02); C908(1.01); C380(1.16)  LDD1629  [23]
 LDCM0426  CL37 HEK-293T C793(2.03); C634(1.06); C908(0.97); C380(1.02)  LDD1630  [23]
 LDCM0428  CL39 HEK-293T C793(2.31); C634(0.98); C908(0.88); C380(0.96)  LDD1632  [23]
 LDCM0429  CL4 HEK-293T C793(4.70); C634(1.02); C908(1.06); C380(1.06)  LDD1633  [23]
 LDCM0430  CL40 HEK-293T C793(0.93); C634(0.95); C908(1.02); C380(1.07)  LDD1634  [23]
 LDCM0431  CL41 HEK-293T C793(4.53); C634(1.10); C908(1.13); C380(1.07)  LDD1635  [23]
 LDCM0432  CL42 HEK-293T C793(1.05); C634(0.86); C908(1.04); C380(1.14)  LDD1636  [23]
 LDCM0433  CL43 HEK-293T C793(1.55); C634(0.92); C908(0.93); C380(1.02)  LDD1637  [23]
 LDCM0434  CL44 HEK-293T C793(1.18); C634(1.04); C908(1.15); C380(1.04)  LDD1638  [23]
 LDCM0435  CL45 HEK-293T C793(3.46); C634(1.08); C908(1.11); C380(1.07)  LDD1639  [23]
 LDCM0436  CL46 HEK-293T C793(2.23); C634(0.84); C908(0.98); C380(1.13)  LDD1640  [23]
 LDCM0437  CL47 HEK-293T C793(1.22); C634(0.81); C908(1.01); C380(0.96)  LDD1641  [23]
 LDCM0438  CL48 HEK-293T C793(1.75); C634(0.96); C908(1.05); C380(1.20)  LDD1642  [23]
 LDCM0439  CL49 HEK-293T C793(1.63); C634(1.07); C908(0.98); C380(1.05)  LDD1643  [23]
 LDCM0440  CL5 HEK-293T C793(1.08); C634(1.04); C908(1.21); C380(1.26)  LDD1644  [23]
 LDCM0441  CL50 HEK-293T C793(3.77); C634(1.07); C908(1.04); C380(0.89)  LDD1645  [23]
 LDCM0443  CL52 HEK-293T C793(1.21); C634(0.97); C908(0.92); C380(0.95)  LDD1646  [23]
 LDCM0444  CL53 HEK-293T C793(7.06); C634(1.33); C908(1.23); C380(1.16)  LDD1647  [23]
 LDCM0445  CL54 HEK-293T C793(4.46); C634(1.61); C908(1.22); C380(1.00)  LDD1648  [23]
 LDCM0446  CL55 HEK-293T C793(1.23); C634(0.92); C908(0.92); C380(1.07)  LDD1649  [23]
 LDCM0447  CL56 HEK-293T C793(1.17); C634(0.93); C908(1.05); C380(1.16)  LDD1650  [23]
 LDCM0448  CL57 HEK-293T C793(4.01); C634(1.35); C908(1.28); C380(1.05)  LDD1651  [23]
 LDCM0449  CL58 HEK-293T C793(2.52); C634(0.96); C908(0.95); C380(1.02)  LDD1652  [23]
 LDCM0450  CL59 HEK-293T C793(1.55); C634(0.84); C908(0.95); C380(1.06)  LDD1653  [23]
 LDCM0451  CL6 HEK-293T C793(3.74); C634(2.02); C908(1.15); C380(1.08)  LDD1654  [23]
 LDCM0452  CL60 HEK-293T C793(2.22); C634(1.09); C908(0.99); C380(1.04)  LDD1655  [23]
 LDCM0453  CL61 HEK-293T C793(0.99); C634(1.00); C908(1.00); C380(1.07)  LDD1656  [23]
 LDCM0454  CL62 HEK-293T C793(1.04); C634(0.95); C908(0.91); C380(0.99)  LDD1657  [23]
 LDCM0455  CL63 HEK-293T C793(0.99); C634(0.93); C908(0.94); C380(0.96)  LDD1658  [23]
 LDCM0456  CL64 HEK-293T C793(12.75); C634(1.37); C908(1.09); C380(0.98)  LDD1659  [23]
 LDCM0457  CL65 HEK-293T C793(1.00); C634(1.01); C908(0.94); C380(1.03)  LDD1660  [23]
 LDCM0458  CL66 HEK-293T C793(1.47); C634(1.03); C908(0.95); C380(0.99)  LDD1661  [23]
 LDCM0459  CL67 HEK-293T C793(1.07); C634(0.94); C908(0.96); C380(1.06)  LDD1662  [23]
 LDCM0460  CL68 HEK-293T C793(2.71); C634(0.98); C908(1.05); C380(1.04)  LDD1663  [23]
 LDCM0461  CL69 HEK-293T C793(3.57); C634(1.04); C908(1.18); C380(0.98)  LDD1664  [23]
 LDCM0462  CL7 HEK-293T C793(1.63); C634(1.04); C908(0.92); C380(1.19)  LDD1665  [23]
 LDCM0463  CL70 HEK-293T C793(1.34); C634(0.82); C908(0.92); C380(1.18)  LDD1666  [23]
 LDCM0464  CL71 HEK-293T C793(1.91); C634(0.95); C908(0.96); C380(1.10)  LDD1667  [23]
 LDCM0465  CL72 HEK-293T C793(1.16); C634(0.97); C908(0.93); C380(0.99)  LDD1668  [23]
 LDCM0466  CL73 HEK-293T C793(2.56); C634(1.16); C908(1.01); C380(0.99)  LDD1669  [23]
 LDCM0467  CL74 HEK-293T C793(1.01); C634(1.00); C908(1.00); C380(1.00)  LDD1670  [23]
 LDCM0469  CL76 HEK-293T C793(1.01); C634(0.92); C908(0.99); C380(1.02)  LDD1672  [23]
 LDCM0470  CL77 HEK-293T C793(4.48); C634(1.25); C908(1.14); C380(1.03)  LDD1673  [23]
 LDCM0471  CL78 HEK-293T C793(0.98); C634(0.85); C908(0.90); C380(1.00)  LDD1674  [23]
 LDCM0472  CL79 HEK-293T C793(1.17); C634(0.98); C908(0.96); C380(1.04)  LDD1675  [23]
 LDCM0473  CL8 HEK-293T C793(5.38); C634(3.29); C908(4.60); C380(1.71)  LDD1676  [23]
 LDCM0474  CL80 HEK-293T C793(1.02); C634(0.99); C908(1.01); C380(0.99)  LDD1677  [23]
 LDCM0475  CL81 HEK-293T C793(1.30); C634(1.03); C908(1.24); C380(1.03)  LDD1678  [23]
 LDCM0476  CL82 HEK-293T C793(1.16); C634(0.72); C908(0.90); C380(1.09)  LDD1679  [23]
 LDCM0477  CL83 HEK-293T C793(2.60); C634(1.01); C908(0.95); C380(0.99)  LDD1680  [23]
 LDCM0478  CL84 HEK-293T C793(6.74); C634(1.38); C908(1.07); C380(1.05)  LDD1681  [23]
 LDCM0479  CL85 HEK-293T C793(1.06); C634(1.04); C908(0.96); C380(1.02)  LDD1682  [23]
 LDCM0480  CL86 HEK-293T C793(1.39); C634(1.05); C908(0.92); C380(0.88)  LDD1683  [23]
 LDCM0481  CL87 HEK-293T C793(1.66); C634(1.04); C908(1.00); C380(1.03)  LDD1684  [23]
 LDCM0482  CL88 HEK-293T C793(1.07); C634(0.96); C908(0.96); C380(1.00)  LDD1685  [23]
 LDCM0483  CL89 HEK-293T C793(1.17); C634(0.93); C908(1.06); C380(1.02)  LDD1686  [23]
 LDCM0484  CL9 HEK-293T C793(2.85); C634(1.00); C908(1.37); C380(1.25)  LDD1687  [23]
 LDCM0485  CL90 HEK-293T C793(4.77); C634(3.86); C908(1.64); C380(1.52)  LDD1688  [23]
 LDCM0486  CL91 HEK-293T C793(1.22); C634(0.92); C908(0.94); C380(1.03)  LDD1689  [23]
 LDCM0487  CL92 HEK-293T C793(4.32); C634(1.06); C908(1.07); C380(1.08)  LDD1690  [23]
 LDCM0488  CL93 HEK-293T C793(4.69); C634(1.28); C908(1.16); C380(1.06)  LDD1691  [23]
 LDCM0489  CL94 HEK-293T C793(1.43); C634(0.75); C908(0.93); C380(1.15)  LDD1692  [23]
 LDCM0490  CL95 HEK-293T C793(21.32); C634(4.16); C908(1.48); C380(1.15)  LDD1693  [23]
 LDCM0491  CL96 HEK-293T C793(5.76); C634(1.80); C908(1.08); C380(1.18)  LDD1694  [23]
 LDCM0492  CL97 HEK-293T C793(4.20); C634(1.31); C908(0.96); C380(1.08)  LDD1695  [23]
 LDCM0493  CL98 HEK-293T C793(3.65); C634(1.11); C908(0.88); C380(0.92)  LDD1696  [23]
 LDCM0494  CL99 HEK-293T C793(1.26); C634(1.01); C908(0.89); C380(0.95)  LDD1697  [23]
 LDCM0185  Compound 17 HEK-293T 6.06  LDD0512  [20]
 LDCM0634  CY-0357 Hep-G2 C511(50.00); C312(1.03)  LDD2228  [19]
 LDCM0495  E2913 HEK-293T C793(1.07); C634(0.86); C908(0.84); C380(0.98)  LDD1698  [23]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C912(0.80); C125(0.48)  LDD1702  [4]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [6]
 LDCM0625  F8 Ramos C296(1.49); C912(2.61); C125(1.12); 1.19  LDD2187  [24]
 LDCM0572  Fragment10 Ramos C296(0.80); C908(1.11); 1.11; C511(1.17)  LDD2189  [24]
 LDCM0573  Fragment11 Ramos C296(0.08); C912(1.86); C908(3.50); C125(0.38)  LDD2190  [24]
 LDCM0574  Fragment12 Ramos C296(1.35); C908(1.36); 1.03; C511(1.87)  LDD2191  [24]
 LDCM0575  Fragment13 Ramos C296(0.92); C912(0.97); C908(0.35); C125(1.39)  LDD2192  [24]
 LDCM0576  Fragment14 Ramos C296(1.98); C908(1.65); 3.47; C511(6.25)  LDD2193  [24]
 LDCM0579  Fragment20 Ramos C296(2.06); C511(3.62); C312(3.74); C380(2.29)  LDD2194  [24]
 LDCM0580  Fragment21 Ramos C296(1.05); C912(0.42); C908(0.50); C125(1.44)  LDD2195  [24]
 LDCM0582  Fragment23 Ramos C296(1.39); C912(1.90); C908(0.82); 2.22  LDD2196  [24]
 LDCM0578  Fragment27 Ramos C296(0.91); C912(0.70); C908(1.44); C125(1.07)  LDD2197  [24]
 LDCM0586  Fragment28 Ramos C296(0.64); C912(0.99); C908(0.82); C125(0.99)  LDD2198  [24]
 LDCM0588  Fragment30 Ramos C296(0.99); C912(0.95); C908(1.04); C125(1.39)  LDD2199  [24]
 LDCM0589  Fragment31 Ramos C296(0.89); C912(1.13); C908(0.53); 1.38  LDD2200  [24]
 LDCM0590  Fragment32 Ramos C296(0.82); C908(2.30); C125(1.78); 1.10  LDD2201  [24]
 LDCM0468  Fragment33 HEK-293T C793(1.43); C634(0.96); C908(0.86); C380(1.07)  LDD1671  [23]
 LDCM0596  Fragment38 Ramos C296(0.87); C912(0.18); C908(0.13); C125(1.63)  LDD2203  [24]
 LDCM0566  Fragment4 Ramos C296(1.44); C908(2.56); 1.76; C511(2.09)  LDD2184  [24]
 LDCM0427  Fragment51 HEK-293T C793(1.09); C634(0.98); C908(1.12); C380(0.98)  LDD1631  [23]
 LDCM0610  Fragment52 Ramos C296(0.98); C912(0.64); C908(1.11); C125(1.77)  LDD2204  [24]
 LDCM0614  Fragment56 Ramos C296(1.01); C912(0.51); C908(0.87); C125(1.61)  LDD2205  [24]
 LDCM0569  Fragment7 Ramos C296(1.77); C912(2.64); C908(1.11); 2.41  LDD2186  [24]
 LDCM0571  Fragment9 Ramos C296(2.56); C511(3.62); C312(4.80); C380(2.06)  LDD2188  [24]
 LDCM0015  HNE MDA-MB-231 C908(1.00)  LDD0346  [24]
 LDCM0107  IAA HeLa C303(0.00); C312(0.00); H892(0.00); C530(0.00)  LDD0221  [16]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [3]
 LDCM0022  KB02 HEK-293T C793(0.22); C634(0.91); C908(0.91); C380(1.04)  LDD1492  [23]
 LDCM0023  KB03 Jurkat C908(5.10); C793(8.47); C912(10.83)  LDD0209  [7]
 LDCM0024  KB05 COLO792 C827(3.62); C946(3.71); C296(3.52)  LDD3310  [25]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C511(0.86)  LDD2102  [4]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C511(0.43); C793(0.39)  LDD2121  [4]
 LDCM0109  NEM HeLa N.A.  LDD0223  [16]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C511(0.63); C793(0.47); C634(0.39)  LDD2089  [4]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C511(1.21); C793(1.52)  LDD2090  [4]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C511(0.83); C793(1.08); C634(0.91)  LDD2092  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C511(0.96); C793(1.14); C527(1.06); C634(1.50)  LDD2093  [4]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C511(1.04)  LDD2094  [4]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C511(0.79)  LDD2096  [4]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C511(0.99); C793(1.24); C634(1.14)  LDD2098  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C793(0.87); C527(1.04); C908(1.17)  LDD2099  [4]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C793(1.38)  LDD2105  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C511(0.72); C793(0.86); C312(0.87); C125(0.93)  LDD2107  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C511(0.46); C312(0.48)  LDD2109  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C511(0.97); C793(0.88)  LDD2111  [4]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C793(0.81)  LDD2114  [4]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C511(0.96)  LDD2116  [4]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C511(0.99)  LDD2118  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C511(1.84); C527(1.17)  LDD2119  [4]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C511(0.96)  LDD2120  [4]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C511(1.13); C527(0.18)  LDD2122  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C511(0.78); C527(0.53); C908(0.70)  LDD2123  [4]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C511(1.00)  LDD2124  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C511(0.43); C793(0.85); C908(1.07); C312(0.65)  LDD2125  [4]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C511(0.93)  LDD2126  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C511(0.83); C793(1.20); C908(1.28); C312(1.29)  LDD2127  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C511(0.80)  LDD2128  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C793(0.99); C527(0.84)  LDD2129  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C527(0.51)  LDD2134  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C511(0.80); C793(0.78); C125(1.11)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C511(1.16); C793(1.67); C908(1.29); C312(1.24)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C511(1.12); C908(1.10); C312(0.83)  LDD2137  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C793(1.29)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C511(0.58); C793(0.60); C312(0.65)  LDD2140  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C793(0.99)  LDD2141  [4]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C511(1.05)  LDD2143  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C511(1.68); C527(1.39)  LDD2144  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C511(0.79); C793(0.83); C908(0.81); C125(0.95)  LDD2146  [4]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C511(1.77)  LDD2147  [4]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C511(1.01)  LDD2149  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C511(0.40); C793(0.35); C634(0.54)  LDD2150  [4]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C511(1.01); C530(0.86)  LDD2151  [4]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C793(3.16)  LDD2153  [4]
 LDCM0627  NUDT7-COV-1 HEK-293T C793(1.11); C634(0.71); C125(0.43)  LDD2206  [26]
 LDCM0628  OTUB2-COV-1 HEK-293T C125(15.00); C60(1.35); C511(0.76); C634(0.67)  LDD2207  [26]
 LDCM0131  RA190 MM1.R C511(1.75)  LDD0304  [27]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Enoyl-CoA delta isomerase 2 (ECI2) Enoyl-CoA hydratase/isomerase family O75521
GTP cyclohydrolase 1 (GCH1) GTP cyclohydrolase I family P30793
Nucleoside diphosphate kinase A (NME1) NDK family P15531
Bleomycin hydrolase (BLMH) Peptidase C1 family Q13867
ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) Peptidase S14 family Q16740
Protein phosphatase 1 regulatory subunit 1C (PPP1R1C) Protein phosphatase inhibitor 1 family Q8WVI7
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transportin-3 (TNPO3) . Q9Y5L0
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin, type II cytoskeletal 75 (KRT75) Intermediate filament family O95678
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
7 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
15 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
18 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
19 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
20 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
21 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
22 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
23 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
24 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
25 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
26 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
27 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.