Details of the Target

General Information of Target

Target ID LDTP05841
Target Name Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PPP2R5C)
Gene Name PPP2R5C
Gene ID 5527
Synonyms
KIAA0044; Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform; PP2A B subunit isoform B'-gamma; PP2A B subunit isoform B56-gamma; PP2A B subunit isoform PR61-gamma; PP2A B subunit isoform R5-gamma; Renal carcinoma antigen NY-REN-29
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLTCNKAGSRMVVDAANSNGPFQPVVLLHIRDVPPADQEKLFIQKLRQCCVLFDFVSDPL
SDLKWKEVKRAALSEMVEYITHNRNVITEPIYPEVVHMFAVNMFRTLPPSSNPTGAEFDP
EEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLQLLELFDSEDPRERD
FLKTTLHRIYGKFLGLRAYIRKQINNIFYRFIYETEHHNGIAELLEILGSIINGFALPLK
EEHKIFLLKVLLPLHKVKSLSVYHPQLAYCVVQFLEKDSTLTEPVVMALLKYWPKTHSPK
EVMFLNELEEILDVIEPSEFVKIMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLIS
DNAAKILPIMFPSLYRNSKTHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQFKAEKLKEK
LKMKEREEAWVKIENLAKANPQYTVYSQASTMSIPVAMETDGPLFEDVQMLRKTVKDEAH
QAQKDPKKDRPLARRKSELPQDPHTKKALEAHCRADELASQDGR
Target Bioclass
Enzyme
Family
Phosphatase 2A regulatory subunit B56 family
Subcellular location
Nucleus
Function
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation.
Uniprot ID
Q13362
Ensemble ID
ENST00000328724.9
HGNC ID
HGNC:9311

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
DBIA
 Probe Info  		C410(3.36)  LDD3310  [2]
BTD
 Probe Info  		C408(1.62)  LDD2107  [3]
AHL-Pu-1
 Probe Info  		C50(3.54)  LDD0170  [4]
EA-probe
 Probe Info  		N.A.  LDD0440  [5]
HHS-475
 Probe Info  		Y375(0.66); Y391(0.86)  LDD0264  [6]
HHS-465
 Probe Info  		Y375(10.00)  LDD2237  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [8]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [9]
Lodoacetamide azide
 Probe Info  		C513(0.00); C408(0.00)  LDD0037  [10]
WYneN
 Probe Info  		C334(0.00); C408(0.00)  LDD0021  [11]
IPM
 Probe Info  		N.A.  LDD0147  [12]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [13]
Acrolein
 Probe Info  		H387(0.00); C334(0.00)  LDD0217  [14]
Methacrolein
 Probe Info  		C334(0.00); C408(0.00)  LDD0218  [14]
AOyne
 Probe Info  		11.90  LDD0443  [15]
NAIA_5
 Probe Info  		C334(0.00); C270(0.00)  LDD2223  [16]
PAL-AfBPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C255
 Probe Info  		13.83  LDD1928  [17]
FFF probe13
 Probe Info  		13.00  LDD0475  [18]
FFF probe2
 Probe Info  		20.00  LDD0463  [18]
FFF probe3
 Probe Info  		7.78  LDD0464  [18]
FFF probe9
 Probe Info  		5.66  LDD0470  [18]
STS-2
 Probe Info  		N.A.  LDD0138  [19]
VE-P
 Probe Info  		N.A.  LDD0396  [20]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C50(3.54)  LDD0170  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C513(2.97)  LDD0173  [4]
 LDCM0214  AC1 HEK-293T C513(1.34); C408(1.06)  LDD1507  [21]
 LDCM0215  AC10 HEK-293T C513(1.12); C408(1.03)  LDD1508  [21]
 LDCM0226  AC11 HEK-293T C513(0.98); C408(0.93)  LDD1509  [21]
 LDCM0237  AC12 HEK-293T C513(0.95); C408(0.98)  LDD1510  [21]
 LDCM0259  AC14 HEK-293T C513(0.84); C408(1.11)  LDD1512  [21]
 LDCM0270  AC15 HEK-293T C513(0.62); C408(1.01)  LDD1513  [21]
 LDCM0276  AC17 HEK-293T C513(1.13); C408(1.00)  LDD1515  [21]
 LDCM0277  AC18 HEK-293T C513(1.15); C408(0.99)  LDD1516  [21]
 LDCM0278  AC19 HEK-293T C513(1.08); C408(1.00)  LDD1517  [21]
 LDCM0279  AC2 HEK-293T C513(1.24); C408(1.00)  LDD1518  [21]
 LDCM0280  AC20 HEK-293T C513(1.01); C408(0.96)  LDD1519  [21]
 LDCM0281  AC21 HEK-293T C513(0.99); C408(0.96)  LDD1520  [21]
 LDCM0282  AC22 HEK-293T C513(0.91); C408(1.00)  LDD1521  [21]
 LDCM0283  AC23 HEK-293T C513(0.79); C408(1.02)  LDD1522  [21]
 LDCM0284  AC24 HEK-293T C513(1.03); C408(1.02)  LDD1523  [21]
 LDCM0285  AC25 HEK-293T C513(1.10); C408(0.96)  LDD1524  [21]
 LDCM0286  AC26 HEK-293T C513(1.15); C408(0.91)  LDD1525  [21]
 LDCM0287  AC27 HEK-293T C513(0.99); C408(0.96)  LDD1526  [21]
 LDCM0288  AC28 HEK-293T C513(0.99); C408(0.94)  LDD1527  [21]
 LDCM0289  AC29 HEK-293T C513(0.92); C408(0.93)  LDD1528  [21]
 LDCM0290  AC3 HEK-293T C513(1.23); C408(1.00)  LDD1529  [21]
 LDCM0291  AC30 HEK-293T C513(1.02); C408(0.91)  LDD1530  [21]
 LDCM0292  AC31 HEK-293T C513(0.92); C408(1.04)  LDD1531  [21]
 LDCM0293  AC32 HEK-293T C513(1.16); C408(1.03)  LDD1532  [21]
 LDCM0294  AC33 HEK-293T C513(1.17); C408(0.96)  LDD1533  [21]
 LDCM0295  AC34 HEK-293T C513(1.20); C408(1.03)  LDD1534  [21]
 LDCM0296  AC35 HEK-293T C513(1.00); C408(1.00)  LDD1535  [21]
 LDCM0297  AC36 HEK-293T C513(1.06); C408(1.00)  LDD1536  [21]
 LDCM0298  AC37 HEK-293T C513(0.98); C408(0.94)  LDD1537  [21]
 LDCM0299  AC38 HEK-293T C513(0.90); C408(0.97)  LDD1538  [21]
 LDCM0300  AC39 HEK-293T C513(1.04); C408(1.06)  LDD1539  [21]
 LDCM0301  AC4 HEK-293T C513(1.32); C408(1.01)  LDD1540  [21]
 LDCM0302  AC40 HEK-293T C513(0.99); C408(1.01)  LDD1541  [21]
 LDCM0303  AC41 HEK-293T C513(1.11); C408(1.02)  LDD1542  [21]
 LDCM0304  AC42 HEK-293T C513(1.33); C408(0.98)  LDD1543  [21]
 LDCM0305  AC43 HEK-293T C513(0.96); C408(1.01)  LDD1544  [21]
 LDCM0306  AC44 HEK-293T C513(1.04); C408(0.96)  LDD1545  [21]
 LDCM0307  AC45 HEK-293T C513(1.04); C408(0.94)  LDD1546  [21]
 LDCM0308  AC46 HEK-293T C513(0.96); C408(0.99)  LDD1547  [21]
 LDCM0309  AC47 HEK-293T C513(1.02); C408(1.07)  LDD1548  [21]
 LDCM0310  AC48 HEK-293T C513(1.04); C408(0.94)  LDD1549  [21]
 LDCM0311  AC49 HEK-293T C513(1.19); C408(1.00)  LDD1550  [21]
 LDCM0312  AC5 HEK-293T C513(1.13); C408(1.04)  LDD1551  [21]
 LDCM0313  AC50 HEK-293T C513(1.23); C408(0.97)  LDD1552  [21]
 LDCM0314  AC51 HEK-293T C513(1.08); C408(0.96)  LDD1553  [21]
 LDCM0315  AC52 HEK-293T C513(0.93); C408(0.98)  LDD1554  [21]
 LDCM0316  AC53 HEK-293T C513(1.02); C408(0.95)  LDD1555  [21]
 LDCM0317  AC54 HEK-293T C513(0.98); C408(0.93)  LDD1556  [21]
 LDCM0318  AC55 HEK-293T C513(0.58); C408(1.01)  LDD1557  [21]
 LDCM0319  AC56 HEK-293T C513(1.06); C408(0.99)  LDD1558  [21]
 LDCM0320  AC57 HEK-293T C513(1.24); C408(0.95)  LDD1559  [21]
 LDCM0321  AC58 HEK-293T C513(1.28); C408(0.99)  LDD1560  [21]
 LDCM0322  AC59 HEK-293T C513(1.10); C408(0.97)  LDD1561  [21]
 LDCM0323  AC6 HEK-293T C513(1.22); C408(0.92)  LDD1562  [21]
 LDCM0324  AC60 HEK-293T C513(1.12); C408(0.97)  LDD1563  [21]
 LDCM0325  AC61 HEK-293T C513(1.11); C408(0.91)  LDD1564  [21]
 LDCM0326  AC62 HEK-293T C513(1.09); C408(0.97)  LDD1565  [21]
 LDCM0327  AC63 HEK-293T C513(0.95); C408(1.05)  LDD1566  [21]
 LDCM0328  AC64 HEK-293T C513(1.28); C408(1.00)  LDD1567  [21]
 LDCM0334  AC7 HEK-293T C513(0.92); C408(1.09)  LDD1568  [21]
 LDCM0345  AC8 HEK-293T C513(1.19); C408(0.97)  LDD1569  [21]
 LDCM0248  AKOS034007472 HEK-293T C513(1.05); C408(0.98)  LDD1511  [21]
 LDCM0356  AKOS034007680 HEK-293T C513(1.06); C408(1.08)  LDD1570  [21]
 LDCM0275  AKOS034007705 HEK-293T C513(0.94); C408(0.99)  LDD1514  [21]
 LDCM0156  Aniline NCI-H1299 11.91  LDD0403  [1]
 LDCM0367  CL1 HEK-293T C513(0.84); C408(1.04)  LDD1571  [21]
 LDCM0368  CL10 HEK-293T C513(0.34); C408(1.09)  LDD1572  [21]
 LDCM0369  CL100 HEK-293T C513(1.23); C408(1.01)  LDD1573  [21]
 LDCM0370  CL101 HEK-293T C513(1.17); C408(0.94)  LDD1574  [21]
 LDCM0371  CL102 HEK-293T C513(0.89); C408(1.02)  LDD1575  [21]
 LDCM0372  CL103 HEK-293T C513(0.89); C408(0.93)  LDD1576  [21]
 LDCM0373  CL104 HEK-293T C513(1.08); C408(0.95)  LDD1577  [21]
 LDCM0374  CL105 HEK-293T C513(1.13); C408(0.91)  LDD1578  [21]
 LDCM0375  CL106 HEK-293T C513(0.94); C408(0.93)  LDD1579  [21]
 LDCM0376  CL107 HEK-293T C513(0.94); C408(0.95)  LDD1580  [21]
 LDCM0377  CL108 HEK-293T C513(1.04); C408(0.98)  LDD1581  [21]
 LDCM0378  CL109 HEK-293T C513(1.13); C408(0.96)  LDD1582  [21]
 LDCM0379  CL11 HEK-293T C513(0.31); C408(1.09)  LDD1583  [21]
 LDCM0380  CL110 HEK-293T C513(0.86); C408(1.00)  LDD1584  [21]
 LDCM0381  CL111 HEK-293T C513(0.98); C408(0.89)  LDD1585  [21]
 LDCM0382  CL112 HEK-293T C513(1.12); C408(0.99)  LDD1586  [21]
 LDCM0383  CL113 HEK-293T C513(1.11); C408(0.97)  LDD1587  [21]
 LDCM0384  CL114 HEK-293T C513(0.99); C408(1.05)  LDD1588  [21]
 LDCM0385  CL115 HEK-293T C513(1.03); C408(0.88)  LDD1589  [21]
 LDCM0386  CL116 HEK-293T C513(1.16); C408(0.95)  LDD1590  [21]
 LDCM0387  CL117 HEK-293T C513(1.21); C408(0.94)  LDD1591  [21]
 LDCM0388  CL118 HEK-293T C513(1.04); C408(0.98)  LDD1592  [21]
 LDCM0389  CL119 HEK-293T C513(0.93); C408(1.00)  LDD1593  [21]
 LDCM0390  CL12 HEK-293T C513(0.44); C408(1.04)  LDD1594  [21]
 LDCM0391  CL120 HEK-293T C513(1.11); C408(1.03)  LDD1595  [21]
 LDCM0392  CL121 HEK-293T C513(1.20); C408(0.98)  LDD1596  [21]
 LDCM0393  CL122 HEK-293T C513(1.15); C408(1.00)  LDD1597  [21]
 LDCM0394  CL123 HEK-293T C513(0.94); C408(0.88)  LDD1598  [21]
 LDCM0395  CL124 HEK-293T C513(1.12); C408(1.00)  LDD1599  [21]
 LDCM0396  CL125 HEK-293T C513(1.40); C408(0.93)  LDD1600  [21]
 LDCM0397  CL126 HEK-293T C513(1.10); C408(1.02)  LDD1601  [21]
 LDCM0398  CL127 HEK-293T C513(1.34); C408(0.92)  LDD1602  [21]
 LDCM0399  CL128 HEK-293T C513(1.43); C408(0.95)  LDD1603  [21]
 LDCM0400  CL13 HEK-293T C513(0.90); C408(0.98)  LDD1604  [21]
 LDCM0401  CL14 HEK-293T C513(0.87); C408(1.14)  LDD1605  [21]
 LDCM0402  CL15 HEK-293T C513(0.63); C408(1.16)  LDD1606  [21]
 LDCM0403  CL16 HEK-293T C513(0.74); C408(1.01)  LDD1607  [21]
 LDCM0404  CL17 HEK-293T C513(0.66); C408(1.01)  LDD1608  [21]
 LDCM0405  CL18 HEK-293T C513(0.58); C408(1.02)  LDD1609  [21]
 LDCM0406  CL19 HEK-293T C513(0.52); C408(0.95)  LDD1610  [21]
 LDCM0407  CL2 HEK-293T C513(0.92); C408(1.09)  LDD1611  [21]
 LDCM0408  CL20 HEK-293T C513(0.48); C408(1.05)  LDD1612  [21]
 LDCM0409  CL21 HEK-293T C513(0.41); C408(0.96)  LDD1613  [21]
 LDCM0410  CL22 HEK-293T C513(0.41); C408(1.01)  LDD1614  [21]
 LDCM0411  CL23 HEK-293T C513(0.33); C408(1.04)  LDD1615  [21]
 LDCM0412  CL24 HEK-293T C513(0.43); C408(1.04)  LDD1616  [21]
 LDCM0413  CL25 HEK-293T C513(0.98); C408(1.03)  LDD1617  [21]
 LDCM0414  CL26 HEK-293T C513(0.86); C408(0.95)  LDD1618  [21]
 LDCM0415  CL27 HEK-293T C513(0.84); C408(0.96)  LDD1619  [21]
 LDCM0416  CL28 HEK-293T C513(0.77); C408(1.04)  LDD1620  [21]
 LDCM0417  CL29 HEK-293T C513(0.72); C408(1.01)  LDD1621  [21]
 LDCM0418  CL3 HEK-293T C513(0.69); C408(1.00)  LDD1622  [21]
 LDCM0419  CL30 HEK-293T C513(0.63); C408(0.98)  LDD1623  [21]
 LDCM0420  CL31 HEK-293T C513(0.56); C408(0.95)  LDD1624  [21]
 LDCM0421  CL32 HEK-293T C513(0.48); C408(0.97)  LDD1625  [21]
 LDCM0422  CL33 HEK-293T C513(0.40); C408(1.04)  LDD1626  [21]
 LDCM0423  CL34 HEK-293T C513(0.40); C408(1.09)  LDD1627  [21]
 LDCM0424  CL35 HEK-293T C513(0.33); C408(1.05)  LDD1628  [21]
 LDCM0425  CL36 HEK-293T C513(0.44); C408(1.01)  LDD1629  [21]
 LDCM0426  CL37 HEK-293T C513(1.22); C408(0.94)  LDD1630  [21]
 LDCM0428  CL39 HEK-293T C513(0.85); C408(0.92)  LDD1632  [21]
 LDCM0429  CL4 HEK-293T C513(0.80); C408(0.94)  LDD1633  [21]
 LDCM0430  CL40 HEK-293T C513(0.86); C408(1.03)  LDD1634  [21]
 LDCM0431  CL41 HEK-293T C513(0.71); C408(0.96)  LDD1635  [21]
 LDCM0432  CL42 HEK-293T C513(0.77); C408(0.96)  LDD1636  [21]
 LDCM0433  CL43 HEK-293T C513(0.54); C408(1.00)  LDD1637  [21]
 LDCM0434  CL44 HEK-293T C513(0.52); C408(0.97)  LDD1638  [21]
 LDCM0435  CL45 HEK-293T C513(0.48); C408(0.94)  LDD1639  [21]
 LDCM0436  CL46 HEK-293T C513(0.43); C408(1.02)  LDD1640  [21]
 LDCM0437  CL47 HEK-293T C513(0.32); C408(1.10)  LDD1641  [21]
 LDCM0438  CL48 HEK-293T C513(0.47); C408(1.05)  LDD1642  [21]
 LDCM0439  CL49 HEK-293T C513(1.24); C408(0.98)  LDD1643  [21]
 LDCM0440  CL5 HEK-293T C513(0.76); C408(1.00)  LDD1644  [21]
 LDCM0441  CL50 HEK-293T C513(0.73); C408(1.00)  LDD1645  [21]
 LDCM0443  CL52 HEK-293T C513(0.85); C408(1.05)  LDD1646  [21]
 LDCM0444  CL53 HEK-293T C513(0.75); C408(1.04)  LDD1647  [21]
 LDCM0445  CL54 HEK-293T C513(0.57); C408(0.99)  LDD1648  [21]
 LDCM0446  CL55 HEK-293T C513(0.58); C408(0.96)  LDD1649  [21]
 LDCM0447  CL56 HEK-293T C513(0.53); C408(1.02)  LDD1650  [21]
 LDCM0448  CL57 HEK-293T C513(0.43); C408(0.86)  LDD1651  [21]
 LDCM0449  CL58 HEK-293T C513(0.41); C408(1.02)  LDD1652  [21]
 LDCM0450  CL59 HEK-293T C513(0.35); C408(1.12)  LDD1653  [21]
 LDCM0451  CL6 HEK-293T C513(0.63); C408(1.05)  LDD1654  [21]
 LDCM0452  CL60 HEK-293T C513(0.46); C408(1.06)  LDD1655  [21]
 LDCM0453  CL61 HEK-293T C513(1.28); C408(0.91)  LDD1656  [21]
 LDCM0454  CL62 HEK-293T C513(1.17); C408(1.00)  LDD1657  [21]
 LDCM0455  CL63 HEK-293T C513(0.91); C408(0.93)  LDD1658  [21]
 LDCM0456  CL64 HEK-293T C513(0.88); C408(1.02)  LDD1659  [21]
 LDCM0457  CL65 HEK-293T C513(0.84); C408(1.04)  LDD1660  [21]
 LDCM0458  CL66 HEK-293T C513(0.78); C408(0.97)  LDD1661  [21]
 LDCM0459  CL67 HEK-293T C513(0.62); C408(0.95)  LDD1662  [21]
 LDCM0460  CL68 HEK-293T C513(0.49); C408(0.94)  LDD1663  [21]
 LDCM0461  CL69 HEK-293T C513(0.48); C408(0.91)  LDD1664  [21]
 LDCM0462  CL7 HEK-293T C513(0.57); C408(0.98)  LDD1665  [21]
 LDCM0463  CL70 HEK-293T C513(0.44); C408(1.04)  LDD1666  [21]
 LDCM0464  CL71 HEK-293T C513(0.32); C408(1.11)  LDD1667  [21]
 LDCM0465  CL72 HEK-293T C513(0.47); C408(1.02)  LDD1668  [21]
 LDCM0466  CL73 HEK-293T C513(1.14); C408(1.00)  LDD1669  [21]
 LDCM0467  CL74 HEK-293T C513(0.89); C408(1.00)  LDD1670  [21]
 LDCM0469  CL76 HEK-293T C513(1.02); C408(1.02)  LDD1672  [21]
 LDCM0470  CL77 HEK-293T C513(0.81); C408(0.90)  LDD1673  [21]
 LDCM0471  CL78 HEK-293T C513(0.64); C408(1.06)  LDD1674  [21]
 LDCM0472  CL79 HEK-293T C513(0.65); C408(0.97)  LDD1675  [21]
 LDCM0473  CL8 HEK-293T C513(0.39); C408(1.56)  LDD1676  [21]
 LDCM0474  CL80 HEK-293T C513(0.58); C408(0.99)  LDD1677  [21]
 LDCM0475  CL81 HEK-293T C513(0.53); C408(0.92)  LDD1678  [21]
 LDCM0476  CL82 HEK-293T C513(0.49); C408(0.97)  LDD1679  [21]
 LDCM0477  CL83 HEK-293T C513(0.44); C408(1.07)  LDD1680  [21]
 LDCM0478  CL84 HEK-293T C513(0.48); C408(1.02)  LDD1681  [21]
 LDCM0479  CL85 HEK-293T C513(1.44); C408(1.01)  LDD1682  [21]
 LDCM0480  CL86 HEK-293T C513(1.08); C408(0.98)  LDD1683  [21]
 LDCM0481  CL87 HEK-293T C513(1.26); C408(0.90)  LDD1684  [21]
 LDCM0482  CL88 HEK-293T C513(1.22); C408(1.00)  LDD1685  [21]
 LDCM0483  CL89 HEK-293T C513(1.14); C408(0.98)  LDD1686  [21]
 LDCM0484  CL9 HEK-293T C513(0.44); C408(1.01)  LDD1687  [21]
 LDCM0485  CL90 HEK-293T C513(0.80); C408(1.15)  LDD1688  [21]
 LDCM0486  CL91 HEK-293T C513(0.78); C408(0.97)  LDD1689  [21]
 LDCM0487  CL92 HEK-293T C513(0.66); C408(0.93)  LDD1690  [21]
 LDCM0488  CL93 HEK-293T C513(0.53); C408(0.92)  LDD1691  [21]
 LDCM0489  CL94 HEK-293T C513(0.53); C408(0.95)  LDD1692  [21]
 LDCM0490  CL95 HEK-293T C513(0.41); C408(1.22)  LDD1693  [21]
 LDCM0491  CL96 HEK-293T C513(0.59); C408(0.96)  LDD1694  [21]
 LDCM0492  CL97 HEK-293T C513(1.16); C408(0.92)  LDD1695  [21]
 LDCM0493  CL98 HEK-293T C513(1.13); C408(1.03)  LDD1696  [21]
 LDCM0494  CL99 HEK-293T C513(1.31); C408(0.93)  LDD1697  [21]
 LDCM0495  E2913 HEK-293T C513(0.87); C408(0.84)  LDD1698  [21]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C408(3.49)  LDD1702  [3]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [5]
 LDCM0625  F8 Ramos C408(0.87); C513(1.11); C334(1.29)  LDD2187  [22]
 LDCM0572  Fragment10 Ramos C408(1.44); C513(1.04); C334(2.14)  LDD2189  [22]
 LDCM0573  Fragment11 Ramos C408(0.65); C513(0.04); C270(1.92)  LDD2190  [22]
 LDCM0574  Fragment12 Ramos C408(1.45); C513(0.85); C334(2.37)  LDD2191  [22]
 LDCM0575  Fragment13 Ramos C408(0.90); C513(0.98); C334(1.18)  LDD2192  [22]
 LDCM0576  Fragment14 Ramos C408(1.35); C513(1.08); C334(3.11); C270(1.01)  LDD2193  [22]
 LDCM0579  Fragment20 Ramos C408(2.50); C513(0.95); C334(3.25)  LDD2194  [22]
 LDCM0580  Fragment21 Ramos C408(0.90); C334(1.12)  LDD2195  [22]
 LDCM0582  Fragment23 Ramos C408(2.70); C513(1.35); C334(2.96)  LDD2196  [22]
 LDCM0578  Fragment27 Ramos C408(0.75); C513(0.84); C334(0.93)  LDD2197  [22]
 LDCM0586  Fragment28 Ramos C408(0.61); C513(0.56); C334(0.77); C270(2.02)  LDD2198  [22]
 LDCM0588  Fragment30 Ramos C408(1.09); C513(1.45); C334(1.85)  LDD2199  [22]
 LDCM0589  Fragment31 Ramos C408(0.82); C334(2.21)  LDD2200  [22]
 LDCM0590  Fragment32 Ramos C408(0.87); C334(1.52)  LDD2201  [22]
 LDCM0468  Fragment33 HEK-293T C513(0.94); C408(0.92)  LDD1671  [21]
 LDCM0596  Fragment38 Ramos C408(0.98); C334(1.39)  LDD2203  [22]
 LDCM0566  Fragment4 Ramos C408(1.14); C513(0.54); C334(2.17)  LDD2184  [22]
 LDCM0427  Fragment51 HEK-293T C513(0.99); C408(0.97)  LDD1631  [21]
 LDCM0610  Fragment52 Ramos C408(0.87); C513(1.28); C334(2.38)  LDD2204  [22]
 LDCM0614  Fragment56 Ramos C408(0.96); C513(1.29); C334(1.57)  LDD2205  [22]
 LDCM0569  Fragment7 Ramos C408(1.29); C513(0.80); C334(2.27)  LDD2186  [22]
 LDCM0571  Fragment9 Ramos C408(2.62); C513(0.93); C334(3.77)  LDD2188  [22]
 LDCM0116  HHS-0101 DM93 Y375(0.66); Y391(0.86)  LDD0264  [6]
 LDCM0117  HHS-0201 DM93 Y375(0.63); Y391(0.79)  LDD0265  [6]
 LDCM0118  HHS-0301 DM93 Y375(0.80); Y391(1.68)  LDD0266  [6]
 LDCM0119  HHS-0401 DM93 Y375(0.62); Y391(0.96)  LDD0267  [6]
 LDCM0120  HHS-0701 DM93 Y391(1.04); Y375(1.38)  LDD0268  [6]
 LDCM0015  HNE MDA-MB-231 C334(1.27)  LDD0346  [22]
 LDCM0107  IAA HeLa N.A.  LDD0221  [14]
 LDCM0022  KB02 HEK-293T C408(0.90)  LDD1492  [21]
 LDCM0023  KB03 HEK-293T C408(1.06)  LDD1497  [21]
 LDCM0024  KB05 COLO792 C410(3.36)  LDD3310  [2]
 LDCM0109  NEM HeLa H387(0.00); H339(0.00); H82(0.00)  LDD0223  [14]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C408(1.62)  LDD2107  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase Mdm2 (MDM2) MDM2/MDM4 family Q00987
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PPP2R1A) Phosphatase 2A regulatory subunit A family P30153
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PPP2R1B) Phosphatase 2A regulatory subunit A family P30154
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PPP2CA) PPP phosphatase family P67775
Serine/threonine-protein kinase Chk2 (CHEK2) CAMK Ser/Thr protein kinase family O96017
RAF proto-oncogene serine/threonine-protein kinase (RAF1) TKL Ser/Thr protein kinase family P04049
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cellular tumor antigen p53 (TP53) P53 family P04637
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Radiation-inducible immediate-early gene IEX-1 (IER3) IER3 family P46695

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
(2s3s4e6e8s9s)-3-amino-9-methoxy-268-trimethyl-10-phenyldeca-46-dienoic Acid . DB06905
268-trimethyl-3-amino-9-benzyl-9-methoxynonanoic Acid . DB02506

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
14 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
15 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
16 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
17 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
18 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
19 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
20 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
21 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
22 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578