Details of the Target

General Information of Target

Target ID LDTP02961
Target Name Large ribosomal subunit protein uL22 (RPL17)
Gene Name RPL17
Gene ID 6139
Synonyms
Large ribosomal subunit protein uL22; 60S ribosomal protein L17; 60S ribosomal protein L23; PD-1
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MVRYSLDPENPTKSCKSRGSNLRVHFKNTRETAQAIKGMHIRKATKYLKDVTLQKQCVPF
RRYNGGVGRCAQAKQWGWTQGRWPKKSAEFLLHMLKNAESNAELKGLDVDSLVIEHIQVN
KAPKMRRRTYRAHGRINPYMSSPCHIEMILTEKEQIVPKPEEEVAQKKKISQKKLKKQKL
MARE
Target Bioclass
Other
Family
Universal ribosomal protein uL22 family
Subcellular location
Cytoplasm
Function Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Uniprot ID
P18621
Ensemble ID
ENST00000579248.5
HGNC ID
HGNC:10307

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
KMCH1 SNV: p.A165S DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 43 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
P2
 Probe Info  		2.45  LDD0449  [2]
P3
 Probe Info  		2.33  LDD0450  [2]
P8
 Probe Info  		1.92  LDD0451  [2]
A-EBA
 Probe Info  		2.80  LDD0215  [3]
CY-1
 Probe Info  		100.00  LDD0243  [4]
CY4
 Probe Info  		6.91  LDD0244  [4]
N1
 Probe Info  		100.00  LDD0242  [4]
C-Sul
 Probe Info  		2.79  LDD0066  [5]
TH211
 Probe Info  		Y4(9.52)  LDD0257  [6]
TH216
 Probe Info  		Y47(20.00); Y63(20.00); Y139(17.71); Y4(7.06)  LDD0259  [6]
YN-1
 Probe Info  		100.00  LDD0444  [7]
YN-4
 Probe Info  		100.00  LDD0445  [7]
STPyne
 Probe Info  		K153(7.14); K179(4.70); K27(6.67); K37(0.94)  LDD0277  [8]
ONAyne
 Probe Info  		N.A.  LDD0273  [8]
BTD
 Probe Info  		C15(2.92)  LDD2096  [9]
EA-probe
 Probe Info  		N.A.  LDD0440  [10]
DBIA
 Probe Info  		C144(4.68)  LDD0204  [11]
HHS-482
 Probe Info  		Y47(0.81)  LDD0285  [12]
5E-2FA
 Probe Info  		N.A.  LDD2235  [13]
AMP probe
 Probe Info  		K55(0.00); K167(0.00); K168(0.00)  LDD0200  [14]
ATP probe
 Probe Info  		K55(0.00); K167(0.00); K168(0.00); K49(0.00)  LDD0199  [14]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [15]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [16]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [17]
Lodoacetamide azide
 Probe Info  		C144(0.00); C57(0.00)  LDD0037  [15]
ATP probe
 Probe Info  		K37(0.00); K13(0.00); K96(0.00); K167(0.00)  LDD0035  [18]
JW-RF-010
 Probe Info  		C70(0.00); C144(0.00); C15(0.00); C57(0.00)  LDD0026  [19]
NAIA_4
 Probe Info  		N.A.  LDD2226  [20]
TFBX
 Probe Info  		C57(0.00); C15(0.00); C144(0.00)  LDD0027  [19]
WYneN
 Probe Info  		N.A.  LDD0021  [21]
1d-yne
 Probe Info  		K124(0.00); K105(0.00)  LDD0356  [22]
IPM
 Probe Info  		C57(0.00); C144(0.00)  LDD0005  [21]
NHS
 Probe Info  		N.A.  LDD0010  [21]
SF
 Probe Info  		Y4(0.00); Y63(0.00); Y47(0.00); K86(0.00)  LDD0028  [23]
Phosphinate-6
 Probe Info  		C70(0.00); C57(0.00); C144(0.00); C15(0.00)  LDD0018  [24]
1c-yne
 Probe Info  		K159(0.00); K74(0.00); K105(0.00); K153(0.00)  LDD0228  [22]
Acrolein
 Probe Info  		H116(0.00); C144(0.00); H93(0.00)  LDD0217  [25]
W1
 Probe Info  		C144(0.00); S87(0.00); H93(0.00)  LDD0236  [26]
AOyne
 Probe Info  		15.00  LDD0443  [27]
MPP-AC
 Probe Info  		N.A.  LDD0428  [28]
NAIA_5
 Probe Info  		C70(0.00); C57(0.00); C144(0.00); C15(0.00)  LDD2223  [20]
HHS-475
 Probe Info  		Y139(0.76); Y4(1.36)  LDD2238  [29]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-2
 Probe Info  		N.A.  LDD0138  [30]
DA-2
 Probe Info  		N.A.  LDD0072  [31]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C57(2.33)  LDD0371  [32]
 LDCM0214  AC1 HEK-293T C144(1.08)  LDD1507  [33]
 LDCM0215  AC10 HEK-293T C144(0.99)  LDD1508  [33]
 LDCM0226  AC11 HEK-293T C144(0.91)  LDD1509  [33]
 LDCM0237  AC12 HEK-293T C144(0.90)  LDD1510  [33]
 LDCM0259  AC14 HEK-293T C144(0.91)  LDD1512  [33]
 LDCM0270  AC15 HEK-293T C144(0.96); C57(1.85)  LDD1513  [33]
 LDCM0276  AC17 HEK-293T C144(1.02)  LDD1515  [33]
 LDCM0277  AC18 HEK-293T C144(0.99)  LDD1516  [33]
 LDCM0278  AC19 HEK-293T C144(1.03)  LDD1517  [33]
 LDCM0279  AC2 HEK-293T C144(1.08)  LDD1518  [33]
 LDCM0280  AC20 HEK-293T C144(0.97)  LDD1519  [33]
 LDCM0281  AC21 HEK-293T C144(0.90); C57(1.08)  LDD1520  [33]
 LDCM0282  AC22 HEK-293T C144(1.03)  LDD1521  [33]
 LDCM0283  AC23 HEK-293T C144(0.97); C57(1.01)  LDD1522  [33]
 LDCM0284  AC24 HEK-293T C144(0.95)  LDD1523  [33]
 LDCM0285  AC25 HEK-293T C144(1.02)  LDD1524  [33]
 LDCM0286  AC26 HEK-293T C144(1.01)  LDD1525  [33]
 LDCM0287  AC27 HEK-293T C144(0.97)  LDD1526  [33]
 LDCM0288  AC28 HEK-293T C144(1.05)  LDD1527  [33]
 LDCM0289  AC29 HEK-293T C144(0.97); C57(1.02)  LDD1528  [33]
 LDCM0290  AC3 HEK-293T C144(1.01)  LDD1529  [33]
 LDCM0291  AC30 HEK-293T C144(1.00)  LDD1530  [33]
 LDCM0292  AC31 HEK-293T C144(1.05); C57(1.16)  LDD1531  [33]
 LDCM0293  AC32 HEK-293T C144(1.09)  LDD1532  [33]
 LDCM0294  AC33 HEK-293T C144(0.99)  LDD1533  [33]
 LDCM0295  AC34 HEK-293T C144(0.96)  LDD1534  [33]
 LDCM0296  AC35 HEK-293T C144(1.01)  LDD1535  [33]
 LDCM0297  AC36 HEK-293T C144(0.99)  LDD1536  [33]
 LDCM0298  AC37 HEK-293T C144(1.00); C57(0.92)  LDD1537  [33]
 LDCM0299  AC38 HEK-293T C144(0.98)  LDD1538  [33]
 LDCM0300  AC39 HEK-293T C144(0.94); C57(0.91)  LDD1539  [33]
 LDCM0301  AC4 HEK-293T C144(1.10)  LDD1540  [33]
 LDCM0302  AC40 HEK-293T C144(1.01)  LDD1541  [33]
 LDCM0303  AC41 HEK-293T C144(0.96)  LDD1542  [33]
 LDCM0304  AC42 HEK-293T C144(1.00)  LDD1543  [33]
 LDCM0305  AC43 HEK-293T C144(0.93)  LDD1544  [33]
 LDCM0306  AC44 HEK-293T C144(0.93)  LDD1545  [33]
 LDCM0307  AC45 HEK-293T C144(0.94); C57(1.02)  LDD1546  [33]
 LDCM0308  AC46 HEK-293T C144(1.01)  LDD1547  [33]
 LDCM0309  AC47 HEK-293T C144(0.95); C57(1.44)  LDD1548  [33]
 LDCM0310  AC48 HEK-293T C144(1.00)  LDD1549  [33]
 LDCM0311  AC49 HEK-293T C144(0.94)  LDD1550  [33]
 LDCM0312  AC5 HEK-293T C144(1.01); C57(1.07)  LDD1551  [33]
 LDCM0313  AC50 HEK-293T C144(0.99)  LDD1552  [33]
 LDCM0314  AC51 HEK-293T C144(0.98)  LDD1553  [33]
 LDCM0315  AC52 HEK-293T C144(0.89)  LDD1554  [33]
 LDCM0316  AC53 HEK-293T C144(0.93); C57(1.10)  LDD1555  [33]
 LDCM0317  AC54 HEK-293T C144(0.90)  LDD1556  [33]
 LDCM0318  AC55 HEK-293T C144(0.90); C57(0.97)  LDD1557  [33]
 LDCM0319  AC56 HEK-293T C144(0.95)  LDD1558  [33]
 LDCM0320  AC57 HEK-293T C144(0.95)  LDD1559  [33]
 LDCM0321  AC58 HEK-293T C144(0.90)  LDD1560  [33]
 LDCM0322  AC59 HEK-293T C144(0.95)  LDD1561  [33]
 LDCM0323  AC6 HEK-293T C144(1.02)  LDD1562  [33]
 LDCM0324  AC60 HEK-293T C144(1.01)  LDD1563  [33]
 LDCM0325  AC61 HEK-293T C144(0.90); C57(1.06)  LDD1564  [33]
 LDCM0326  AC62 HEK-293T C144(0.90)  LDD1565  [33]
 LDCM0327  AC63 HEK-293T C144(1.00); C57(1.20)  LDD1566  [33]
 LDCM0328  AC64 HEK-293T C144(1.00)  LDD1567  [33]
 LDCM0334  AC7 HEK-293T C144(1.02); C57(1.25)  LDD1568  [33]
 LDCM0345  AC8 HEK-293T C144(1.10)  LDD1569  [33]
 LDCM0248  AKOS034007472 HEK-293T C144(0.91); C57(1.21)  LDD1511  [33]
 LDCM0356  AKOS034007680 HEK-293T C144(0.99)  LDD1570  [33]
 LDCM0275  AKOS034007705 HEK-293T C144(0.92)  LDD1514  [33]
 LDCM0156  Aniline NCI-H1299 12.13  LDD0403  [1]
 LDCM0102  BDHI 8 Jurkat C144(4.68)  LDD0204  [11]
 LDCM0108  Chloroacetamide HeLa C144(0.00); H116(0.00); H93(0.00)  LDD0222  [25]
 LDCM0632  CL-Sc Hep-G2 C57(1.05); C144(0.59)  LDD2227  [20]
 LDCM0367  CL1 HEK-293T C144(0.93)  LDD1571  [33]
 LDCM0368  CL10 HEK-293T C144(0.85)  LDD1572  [33]
 LDCM0369  CL100 HEK-293T C144(1.00)  LDD1573  [33]
 LDCM0370  CL101 HEK-293T C144(0.93)  LDD1574  [33]
 LDCM0371  CL102 HEK-293T C144(0.99)  LDD1575  [33]
 LDCM0372  CL103 HEK-293T C144(0.96)  LDD1576  [33]
 LDCM0373  CL104 HEK-293T C144(0.93)  LDD1577  [33]
 LDCM0374  CL105 HEK-293T C144(1.05)  LDD1578  [33]
 LDCM0375  CL106 HEK-293T C144(0.97)  LDD1579  [33]
 LDCM0376  CL107 HEK-293T C144(0.96)  LDD1580  [33]
 LDCM0377  CL108 HEK-293T C144(0.93)  LDD1581  [33]
 LDCM0378  CL109 HEK-293T C144(1.04)  LDD1582  [33]
 LDCM0379  CL11 HEK-293T C144(0.80); C57(0.15)  LDD1583  [33]
 LDCM0380  CL110 HEK-293T C144(1.08)  LDD1584  [33]
 LDCM0381  CL111 HEK-293T C144(0.97)  LDD1585  [33]
 LDCM0382  CL112 HEK-293T C144(1.01)  LDD1586  [33]
 LDCM0383  CL113 HEK-293T C144(1.01)  LDD1587  [33]
 LDCM0384  CL114 HEK-293T C144(1.04)  LDD1588  [33]
 LDCM0385  CL115 HEK-293T C144(1.00)  LDD1589  [33]
 LDCM0386  CL116 HEK-293T C144(1.04)  LDD1590  [33]
 LDCM0387  CL117 HEK-293T C144(1.01)  LDD1591  [33]
 LDCM0388  CL118 HEK-293T C144(0.93)  LDD1592  [33]
 LDCM0389  CL119 HEK-293T C144(0.98)  LDD1593  [33]
 LDCM0390  CL12 HEK-293T C144(0.71)  LDD1594  [33]
 LDCM0391  CL120 HEK-293T C144(1.01)  LDD1595  [33]
 LDCM0392  CL121 HEK-293T C144(0.93)  LDD1596  [33]
 LDCM0393  CL122 HEK-293T C144(0.92)  LDD1597  [33]
 LDCM0394  CL123 HEK-293T C144(0.98)  LDD1598  [33]
 LDCM0395  CL124 HEK-293T C144(0.86)  LDD1599  [33]
 LDCM0396  CL125 HEK-293T C144(0.75)  LDD1600  [33]
 LDCM0397  CL126 HEK-293T C144(0.84)  LDD1601  [33]
 LDCM0398  CL127 HEK-293T C144(0.88)  LDD1602  [33]
 LDCM0399  CL128 HEK-293T C144(0.88)  LDD1603  [33]
 LDCM0400  CL13 HEK-293T C144(0.86)  LDD1604  [33]
 LDCM0401  CL14 HEK-293T C144(0.85)  LDD1605  [33]
 LDCM0402  CL15 HEK-293T C144(0.84)  LDD1606  [33]
 LDCM0403  CL16 HEK-293T C144(0.82)  LDD1607  [33]
 LDCM0404  CL17 HEK-293T C144(0.79)  LDD1608  [33]
 LDCM0405  CL18 HEK-293T C144(0.75)  LDD1609  [33]
 LDCM0406  CL19 HEK-293T C144(0.62)  LDD1610  [33]
 LDCM0407  CL2 HEK-293T C144(0.84)  LDD1611  [33]
 LDCM0408  CL20 HEK-293T C144(0.66)  LDD1612  [33]
 LDCM0409  CL21 HEK-293T C144(0.67); C57(0.15)  LDD1613  [33]
 LDCM0410  CL22 HEK-293T C144(0.67)  LDD1614  [33]
 LDCM0411  CL23 HEK-293T C144(0.74); C57(0.13)  LDD1615  [33]
 LDCM0412  CL24 HEK-293T C144(0.67)  LDD1616  [33]
 LDCM0413  CL25 HEK-293T C144(0.84)  LDD1617  [33]
 LDCM0414  CL26 HEK-293T C144(0.94)  LDD1618  [33]
 LDCM0415  CL27 HEK-293T C144(0.90)  LDD1619  [33]
 LDCM0416  CL28 HEK-293T C144(0.82)  LDD1620  [33]
 LDCM0417  CL29 HEK-293T C144(0.85)  LDD1621  [33]
 LDCM0418  CL3 HEK-293T C144(0.90)  LDD1622  [33]
 LDCM0419  CL30 HEK-293T C144(0.74)  LDD1623  [33]
 LDCM0420  CL31 HEK-293T C144(0.66)  LDD1624  [33]
 LDCM0421  CL32 HEK-293T C144(0.66)  LDD1625  [33]
 LDCM0422  CL33 HEK-293T C144(0.64); C57(0.19)  LDD1626  [33]
 LDCM0423  CL34 HEK-293T C144(0.66)  LDD1627  [33]
 LDCM0424  CL35 HEK-293T C144(0.71); C57(0.11)  LDD1628  [33]
 LDCM0425  CL36 HEK-293T C144(0.71)  LDD1629  [33]
 LDCM0426  CL37 HEK-293T C144(0.92)  LDD1630  [33]
 LDCM0428  CL39 HEK-293T C144(0.94)  LDD1632  [33]
 LDCM0429  CL4 HEK-293T C144(0.70)  LDD1633  [33]
 LDCM0430  CL40 HEK-293T C144(0.90)  LDD1634  [33]
 LDCM0431  CL41 HEK-293T C144(0.92)  LDD1635  [33]
 LDCM0432  CL42 HEK-293T C144(0.70)  LDD1636  [33]
 LDCM0433  CL43 HEK-293T C144(0.71)  LDD1637  [33]
 LDCM0434  CL44 HEK-293T C144(0.67)  LDD1638  [33]
 LDCM0435  CL45 HEK-293T C144(0.58); C57(0.23)  LDD1639  [33]
 LDCM0436  CL46 HEK-293T C144(0.65)  LDD1640  [33]
 LDCM0437  CL47 HEK-293T C144(0.75); C57(0.14)  LDD1641  [33]
 LDCM0438  CL48 HEK-293T C144(0.66)  LDD1642  [33]
 LDCM0439  CL49 HEK-293T C144(0.81)  LDD1643  [33]
 LDCM0440  CL5 HEK-293T C144(0.74)  LDD1644  [33]
 LDCM0441  CL50 HEK-293T C144(0.91)  LDD1645  [33]
 LDCM0443  CL52 HEK-293T C144(0.89)  LDD1646  [33]
 LDCM0444  CL53 HEK-293T C144(0.59)  LDD1647  [33]
 LDCM0445  CL54 HEK-293T C144(0.73)  LDD1648  [33]
 LDCM0446  CL55 HEK-293T C144(0.69)  LDD1649  [33]
 LDCM0447  CL56 HEK-293T C144(0.66)  LDD1650  [33]
 LDCM0448  CL57 HEK-293T C144(0.66); C57(0.28)  LDD1651  [33]
 LDCM0449  CL58 HEK-293T C144(0.60)  LDD1652  [33]
 LDCM0450  CL59 HEK-293T C144(0.68); C57(0.19)  LDD1653  [33]
 LDCM0451  CL6 HEK-293T C144(0.71)  LDD1654  [33]
 LDCM0452  CL60 HEK-293T C144(0.73)  LDD1655  [33]
 LDCM0453  CL61 HEK-293T C144(0.93)  LDD1656  [33]
 LDCM0454  CL62 HEK-293T C144(1.00)  LDD1657  [33]
 LDCM0455  CL63 HEK-293T C144(0.94)  LDD1658  [33]
 LDCM0456  CL64 HEK-293T C144(0.90)  LDD1659  [33]
 LDCM0457  CL65 HEK-293T C144(0.89)  LDD1660  [33]
 LDCM0458  CL66 HEK-293T C144(0.82)  LDD1661  [33]
 LDCM0459  CL67 HEK-293T C144(0.74)  LDD1662  [33]
 LDCM0460  CL68 HEK-293T C144(0.67)  LDD1663  [33]
 LDCM0461  CL69 HEK-293T C144(0.60); C57(0.39)  LDD1664  [33]
 LDCM0462  CL7 HEK-293T C144(0.67)  LDD1665  [33]
 LDCM0463  CL70 HEK-293T C144(0.69)  LDD1666  [33]
 LDCM0464  CL71 HEK-293T C144(0.64); C57(0.25)  LDD1667  [33]
 LDCM0465  CL72 HEK-293T C144(0.77)  LDD1668  [33]
 LDCM0466  CL73 HEK-293T C144(0.91)  LDD1669  [33]
 LDCM0467  CL74 HEK-293T C144(0.94)  LDD1670  [33]
 LDCM0469  CL76 HEK-293T C144(0.87)  LDD1672  [33]
 LDCM0470  CL77 HEK-293T C144(0.86)  LDD1673  [33]
 LDCM0471  CL78 HEK-293T C144(0.81)  LDD1674  [33]
 LDCM0472  CL79 HEK-293T C144(0.70)  LDD1675  [33]
 LDCM0473  CL8 HEK-293T C144(0.70)  LDD1676  [33]
 LDCM0474  CL80 HEK-293T C144(0.67)  LDD1677  [33]
 LDCM0475  CL81 HEK-293T C144(0.61); C57(0.38)  LDD1678  [33]
 LDCM0476  CL82 HEK-293T C144(0.66)  LDD1679  [33]
 LDCM0477  CL83 HEK-293T C144(0.71); C57(0.42)  LDD1680  [33]
 LDCM0478  CL84 HEK-293T C144(0.66)  LDD1681  [33]
 LDCM0479  CL85 HEK-293T C144(0.80)  LDD1682  [33]
 LDCM0480  CL86 HEK-293T C144(0.78)  LDD1683  [33]
 LDCM0481  CL87 HEK-293T C144(0.76)  LDD1684  [33]
 LDCM0482  CL88 HEK-293T C144(0.75)  LDD1685  [33]
 LDCM0483  CL89 HEK-293T C144(0.70)  LDD1686  [33]
 LDCM0484  CL9 HEK-293T C144(0.64); C57(0.24)  LDD1687  [33]
 LDCM0485  CL90 HEK-293T C144(0.75)  LDD1688  [33]
 LDCM0486  CL91 HEK-293T C144(0.60)  LDD1689  [33]
 LDCM0487  CL92 HEK-293T C144(0.66)  LDD1690  [33]
 LDCM0488  CL93 HEK-293T C144(0.64); C57(0.60)  LDD1691  [33]
 LDCM0489  CL94 HEK-293T C144(0.70)  LDD1692  [33]
 LDCM0490  CL95 HEK-293T C144(0.72); C57(1.09)  LDD1693  [33]
 LDCM0491  CL96 HEK-293T C144(0.60)  LDD1694  [33]
 LDCM0492  CL97 HEK-293T C144(0.97)  LDD1695  [33]
 LDCM0493  CL98 HEK-293T C144(0.99)  LDD1696  [33]
 LDCM0494  CL99 HEK-293T C144(1.02)  LDD1697  [33]
 LDCM0495  E2913 HEK-293T C144(0.92)  LDD1698  [33]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C144(1.33)  LDD1702  [9]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [10]
 LDCM0625  F8 Ramos C144(2.25)  LDD2187  [34]
 LDCM0572  Fragment10 Ramos C144(0.90)  LDD2189  [34]
 LDCM0573  Fragment11 Ramos C144(0.00)  LDD2190  [34]
 LDCM0574  Fragment12 Ramos C144(1.20)  LDD2191  [34]
 LDCM0575  Fragment13 Ramos C144(1.64)  LDD2192  [34]
 LDCM0576  Fragment14 Ramos C144(1.44)  LDD2193  [34]
 LDCM0579  Fragment20 Ramos C144(1.51)  LDD2194  [34]
 LDCM0580  Fragment21 Ramos C144(0.55)  LDD2195  [34]
 LDCM0582  Fragment23 Ramos C144(1.15)  LDD2196  [34]
 LDCM0578  Fragment27 Ramos C144(0.79)  LDD2197  [34]
 LDCM0586  Fragment28 Ramos C144(0.79)  LDD2198  [34]
 LDCM0588  Fragment30 Ramos C144(0.55)  LDD2199  [34]
 LDCM0589  Fragment31 Ramos C144(0.71)  LDD2200  [34]
 LDCM0590  Fragment32 Ramos C144(1.04)  LDD2201  [34]
 LDCM0468  Fragment33 HEK-293T C144(0.88)  LDD1671  [33]
 LDCM0596  Fragment38 Ramos C144(1.33)  LDD2203  [34]
 LDCM0566  Fragment4 Ramos C144(1.39)  LDD2184  [34]
 LDCM0427  Fragment51 HEK-293T C144(0.99)  LDD1631  [33]
 LDCM0610  Fragment52 Ramos C144(0.80)  LDD2204  [34]
 LDCM0614  Fragment56 Ramos C144(0.47)  LDD2205  [34]
 LDCM0569  Fragment7 Ramos C144(1.65)  LDD2186  [34]
 LDCM0571  Fragment9 Ramos C144(1.53)  LDD2188  [34]
 LDCM0107  IAA HeLa H116(0.00); H93(0.00)  LDD0221  [25]
 LDCM0123  JWB131 DM93 Y47(0.81)  LDD0285  [12]
 LDCM0124  JWB142 DM93 Y47(0.47)  LDD0286  [12]
 LDCM0125  JWB146 DM93 Y47(1.06)  LDD0287  [12]
 LDCM0126  JWB150 DM93 Y47(2.99)  LDD0288  [12]
 LDCM0127  JWB152 DM93 Y47(1.76)  LDD0289  [12]
 LDCM0130  JWB211 DM93 Y47(1.13)  LDD0292  [12]
 LDCM0022  KB02 HEK-293T C144(1.10)  LDD1492  [33]
 LDCM0023  KB03 Jurkat C57(117.10)  LDD0209  [11]
 LDCM0024  KB05 COLO792 C144(2.07); C57(5.78)  LDD3310  [35]
 LDCM0109  NEM HeLa H116(0.00); H93(0.00)  LDD0223  [25]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C15(2.92)  LDD2096  [9]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C15(0.63)  LDD2116  [9]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C15(1.18)  LDD2118  [9]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C144(0.86)  LDD2123  [9]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C15(0.49)  LDD2128  [9]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C144(1.19)  LDD2137  [9]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C15(0.22)  LDD2151  [9]
 LDCM0627  NUDT7-COV-1 HEK-293T C144(1.55); C144(1.24)  LDD2206  [36]
 LDCM0628  OTUB2-COV-1 HEK-293T C144(1.68); C144(0.80)  LDD2207  [36]
 LDCM0111  W14 Hep-G2 Q87(0.51)  LDD0238  [26]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
3 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
6 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
7 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
8 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
9 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
10 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
11 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
12 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
13 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
14 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
15 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
16 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
17 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
18 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
19 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
20 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
21 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
22 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
23 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
24 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
25 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
26 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
27 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
28 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
29 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
30 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
31 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
32 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
33 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
34 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
35 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
36 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.