Details of the Target

General Information of Target

Target ID LDTP03479
Target Name SHC-transforming protein 1 (SHC1)
Gene Name SHC1
Gene ID 6464
Synonyms
SHC; SHCA; SHC-transforming protein 1; SHC-transforming protein 3; SHC-transforming protein A; Src homology 2 domain-containing-transforming protein C1; SH2 domain protein C1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDLLPPKPKYNPLRNESLSSLEEGASGSTPPEELPSPSASSLGPILPPLPGDDSPTTLCS
FFPRMSNLRLANPAGGRPGSKGEPGRAADDGEGIVGAAMPDSGPLPLLQDMNKLSGGGGR
RTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALD
FNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPITLTVSTSS
LNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQDV
ISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPL
GGVVDMRLREGAAPGAARPTAPNAQTPSHLGATLPVGQPVGGDPEVRKQMPPPPPCPGRE
LFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLFDMKPFEDALRVPPPPQSVSMA
EQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEG
VVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVERKL
Target Bioclass
Other
Subcellular location
Cytoplasm; Mitochondrion; Mitochondrion matrix
Function
Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span. Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.
Uniprot ID
P29353
Ensemble ID
ENST00000368445.9
HGNC ID
HGNC:10840
ChEMBL ID
CHEMBL5626

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
Probe 1
 Probe Info  		Y427(18.76)  LDD3495  [2]
DBIA
 Probe Info  		C86(1.57)  LDD3310  [3]
EA-probe
 Probe Info  		N.A.  LDD0440  [4]
Acrolein
 Probe Info  		N.A.  LDD0222  [5]
5E-2FA
 Probe Info  		N.A.  LDD2235  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [7]
IA-alkyne
 Probe Info  		C287(0.00); C292(0.00); C169(0.00)  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		C287(0.00); C292(0.00)  LDD0037  [7]
TFBX
 Probe Info  		N.A.  LDD0027  [8]
WYneN
 Probe Info  		N.A.  LDD0021  [9]
IPM
 Probe Info  		C212(0.00); C416(0.00)  LDD0147  [8]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [10]
AOyne
 Probe Info  		10.30  LDD0443  [11]
NAIA_5
 Probe Info  		N.A.  LDD2223  [12]
HHS-465
 Probe Info  		N.A.  LDD2240  [13]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Staurosporine capture compound
 Probe Info  		N.A.  LDD0083  [14]
DA-2
 Probe Info  		N.A.  LDD0071  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C169(1.02); C416(1.01); C248(1.02)  LDD1507  [16]
 LDCM0215  AC10 HEK-293T C416(0.98); C196(0.99); C248(1.08)  LDD1508  [16]
 LDCM0226  AC11 HEK-293T C169(1.09); C416(1.02); C248(1.04)  LDD1509  [16]
 LDCM0237  AC12 HEK-293T C169(0.98); C416(0.97); C248(1.02); C212(1.05)  LDD1510  [16]
 LDCM0259  AC14 HEK-293T C169(0.96); C416(0.89); C196(1.11); C248(1.06)  LDD1512  [16]
 LDCM0270  AC15 HEK-293T C169(0.89); C416(0.98); C248(1.05); C212(1.15)  LDD1513  [16]
 LDCM0276  AC17 HEK-293T C169(0.93); C416(0.96); C248(0.85)  LDD1515  [16]
 LDCM0277  AC18 HEK-293T C416(1.00); C196(0.94); C248(0.90)  LDD1516  [16]
 LDCM0278  AC19 HEK-293T C169(0.90); C416(1.16); C248(0.85)  LDD1517  [16]
 LDCM0279  AC2 HEK-293T C416(0.98); C196(1.10); C248(1.03)  LDD1518  [16]
 LDCM0280  AC20 HEK-293T C169(1.15); C416(0.94); C248(0.96); C212(1.05)  LDD1519  [16]
 LDCM0281  AC21 HEK-293T C169(0.99); C416(0.97); C248(0.99); C212(0.98)  LDD1520  [16]
 LDCM0282  AC22 HEK-293T C169(1.02); C416(0.91); C196(1.02); C248(1.09)  LDD1521  [16]
 LDCM0283  AC23 HEK-293T C169(0.94); C416(1.06); C248(0.99); C212(1.01)  LDD1522  [16]
 LDCM0284  AC24 HEK-293T C169(1.00); C416(0.98); C248(1.01); C212(0.88)  LDD1523  [16]
 LDCM0285  AC25 HEK-293T C169(0.90); C416(1.03); C248(0.88)  LDD1524  [16]
 LDCM0286  AC26 HEK-293T C416(1.05); C196(0.94); C248(1.07)  LDD1525  [16]
 LDCM0287  AC27 HEK-293T C169(1.08); C416(1.06); C248(0.97)  LDD1526  [16]
 LDCM0288  AC28 HEK-293T C169(0.98); C416(0.97); C248(1.10); C212(1.16)  LDD1527  [16]
 LDCM0289  AC29 HEK-293T C169(1.05); C416(1.02); C248(1.02); C212(0.96)  LDD1528  [16]
 LDCM0290  AC3 HEK-293T C169(1.02); C416(1.03); C248(1.03)  LDD1529  [16]
 LDCM0291  AC30 HEK-293T C169(0.89); C416(0.95); C196(1.07); C248(1.07)  LDD1530  [16]
 LDCM0292  AC31 HEK-293T C169(0.93); C416(1.01); C248(0.92); C212(1.07)  LDD1531  [16]
 LDCM0293  AC32 HEK-293T C169(1.01); C416(1.00); C248(0.94); C212(1.13)  LDD1532  [16]
 LDCM0294  AC33 HEK-293T C169(0.99); C416(0.97); C248(1.30)  LDD1533  [16]
 LDCM0295  AC34 HEK-293T C416(0.96); C196(1.07); C248(1.06)  LDD1534  [16]
 LDCM0296  AC35 HEK-293T C169(1.03); C416(0.97); C248(1.07)  LDD1535  [16]
 LDCM0297  AC36 HEK-293T C169(1.07); C416(0.87); C248(1.13); C212(1.17)  LDD1536  [16]
 LDCM0298  AC37 HEK-293T C169(0.98); C416(0.89); C248(1.00); C212(1.00)  LDD1537  [16]
 LDCM0299  AC38 HEK-293T C169(1.04); C416(0.86); C196(1.14); C248(1.08)  LDD1538  [16]
 LDCM0300  AC39 HEK-293T C169(0.89); C416(1.00); C248(0.87); C212(1.08)  LDD1539  [16]
 LDCM0301  AC4 HEK-293T C169(1.07); C416(0.95); C248(1.04); C212(1.27)  LDD1540  [16]
 LDCM0302  AC40 HEK-293T C169(1.11); C416(0.96); C248(1.15); C212(1.00)  LDD1541  [16]
 LDCM0303  AC41 HEK-293T C169(1.10); C416(1.02); C248(0.90)  LDD1542  [16]
 LDCM0304  AC42 HEK-293T C416(1.01); C196(1.03); C248(1.01)  LDD1543  [16]
 LDCM0305  AC43 HEK-293T C169(1.09); C416(0.97); C248(1.14)  LDD1544  [16]
 LDCM0306  AC44 HEK-293T C169(1.25); C416(0.93); C248(1.01); C212(1.24)  LDD1545  [16]
 LDCM0307  AC45 HEK-293T C169(1.01); C416(1.03); C248(1.08); C212(1.06)  LDD1546  [16]
 LDCM0308  AC46 HEK-293T C169(1.08); C416(0.89); C196(1.14); C248(1.04)  LDD1547  [16]
 LDCM0309  AC47 HEK-293T C169(1.00); C416(1.03); C248(1.06); C212(1.12)  LDD1548  [16]
 LDCM0310  AC48 HEK-293T C169(1.10); C416(1.02); C248(1.10); C212(1.28)  LDD1549  [16]
 LDCM0311  AC49 HEK-293T C169(0.96); C416(1.02); C248(1.12)  LDD1550  [16]
 LDCM0312  AC5 HEK-293T C169(0.96); C416(1.02); C248(1.03); C212(1.05)  LDD1551  [16]
 LDCM0313  AC50 HEK-293T C416(0.99); C196(1.07); C248(1.00)  LDD1552  [16]
 LDCM0314  AC51 HEK-293T C169(0.91); C416(1.03); C248(1.16)  LDD1553  [16]
 LDCM0315  AC52 HEK-293T C169(1.14); C416(0.94); C248(1.08); C212(1.10)  LDD1554  [16]
 LDCM0316  AC53 HEK-293T C169(1.04); C416(1.05); C248(0.99); C212(1.07)  LDD1555  [16]
 LDCM0317  AC54 HEK-293T C169(0.98); C416(0.92); C196(1.05); C248(1.02)  LDD1556  [16]
 LDCM0318  AC55 HEK-293T C169(1.03); C416(1.00); C248(1.03); C212(1.07)  LDD1557  [16]
 LDCM0319  AC56 HEK-293T C169(1.15); C416(0.96); C248(0.98); C212(1.06)  LDD1558  [16]
 LDCM0320  AC57 HEK-293T C169(1.13); C416(1.06); C248(0.81)  LDD1559  [16]
 LDCM0321  AC58 HEK-293T C416(0.94); C196(1.05); C248(1.04)  LDD1560  [16]
 LDCM0322  AC59 HEK-293T C169(0.89); C416(0.98); C248(0.93)  LDD1561  [16]
 LDCM0323  AC6 HEK-293T C169(0.97); C416(0.91); C196(1.13); C248(1.14)  LDD1562  [16]
 LDCM0324  AC60 HEK-293T C169(1.08); C416(0.97); C248(0.99); C212(1.20)  LDD1563  [16]
 LDCM0325  AC61 HEK-293T C169(1.03); C416(0.99); C248(0.98); C212(1.14)  LDD1564  [16]
 LDCM0326  AC62 HEK-293T C169(0.98); C416(0.89); C196(1.02); C248(1.10)  LDD1565  [16]
 LDCM0327  AC63 HEK-293T C169(1.16); C416(0.95); C248(1.07); C212(1.17)  LDD1566  [16]
 LDCM0328  AC64 HEK-293T C169(0.92); C416(0.98); C248(1.04); C212(1.22)  LDD1567  [16]
 LDCM0334  AC7 HEK-293T C169(0.91); C416(0.97); C248(1.01); C212(1.05)  LDD1568  [16]
 LDCM0345  AC8 HEK-293T C169(0.97); C416(1.02); C248(1.16); C212(1.05)  LDD1569  [16]
 LDCM0248  AKOS034007472 HEK-293T C169(1.02); C416(0.98); C248(0.98); C212(0.97)  LDD1511  [16]
 LDCM0356  AKOS034007680 HEK-293T C169(1.16); C416(1.10); C248(1.12)  LDD1570  [16]
 LDCM0275  AKOS034007705 HEK-293T C169(1.17); C416(0.98); C248(1.08); C212(0.98)  LDD1514  [16]
 LDCM0156  Aniline NCI-H1299 12.12  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [5]
 LDCM0632  CL-Sc Hep-G2 C169(20.00); C196(1.29)  LDD2227  [12]
 LDCM0367  CL1 HEK-293T C169(1.01); C416(1.00); C196(1.04); C248(0.89)  LDD1571  [16]
 LDCM0368  CL10 HEK-293T C169(0.98); C416(0.73); C196(1.04); C248(1.21)  LDD1572  [16]
 LDCM0369  CL100 HEK-293T C416(1.03); C196(0.93); C248(1.01)  LDD1573  [16]
 LDCM0370  CL101 HEK-293T C169(1.09); C416(1.05); C196(0.95); C248(1.00)  LDD1574  [16]
 LDCM0371  CL102 HEK-293T C169(0.92); C416(0.97); C196(0.89); C248(0.94)  LDD1575  [16]
 LDCM0372  CL103 HEK-293T C169(1.18); C416(0.96); C248(1.14); C212(0.93)  LDD1576  [16]
 LDCM0373  CL104 HEK-293T C416(1.11); C196(0.98); C248(1.09)  LDD1577  [16]
 LDCM0374  CL105 HEK-293T C169(0.98); C416(1.05); C196(0.86); C248(0.94)  LDD1578  [16]
 LDCM0375  CL106 HEK-293T C169(0.98); C416(0.96); C196(1.02); C248(0.83)  LDD1579  [16]
 LDCM0376  CL107 HEK-293T C169(0.80); C416(0.94); C248(0.81); C212(0.96)  LDD1580  [16]
 LDCM0377  CL108 HEK-293T C416(1.06); C196(0.97); C248(1.09)  LDD1581  [16]
 LDCM0378  CL109 HEK-293T C169(0.93); C416(0.99); C196(0.97); C248(0.94)  LDD1582  [16]
 LDCM0379  CL11 HEK-293T C169(1.08); C416(0.91); C248(0.84); C212(0.45)  LDD1583  [16]
 LDCM0380  CL110 HEK-293T C169(0.79); C416(1.05); C196(0.93); C248(1.02)  LDD1584  [16]
 LDCM0381  CL111 HEK-293T C169(0.94); C416(1.03); C248(1.02); C212(1.04)  LDD1585  [16]
 LDCM0382  CL112 HEK-293T C416(1.04); C196(0.94); C248(1.14)  LDD1586  [16]
 LDCM0383  CL113 HEK-293T C169(1.08); C416(0.97); C196(1.10); C248(0.94)  LDD1587  [16]
 LDCM0384  CL114 HEK-293T C169(1.01); C416(0.92); C196(0.83); C248(1.01)  LDD1588  [16]
 LDCM0385  CL115 HEK-293T C169(1.03); C416(0.91); C248(1.04); C212(1.10)  LDD1589  [16]
 LDCM0386  CL116 HEK-293T C416(1.25); C196(1.04); C248(1.08)  LDD1590  [16]
 LDCM0387  CL117 HEK-293T C169(1.12); C416(1.01); C196(0.93); C248(1.20)  LDD1591  [16]
 LDCM0388  CL118 HEK-293T C169(1.05); C416(1.01); C196(1.16); C248(0.92)  LDD1592  [16]
 LDCM0389  CL119 HEK-293T C169(0.87); C416(0.95); C248(0.97); C212(1.04)  LDD1593  [16]
 LDCM0390  CL12 HEK-293T C169(1.04); C416(0.89); C248(1.12); C212(0.45)  LDD1594  [16]
 LDCM0391  CL120 HEK-293T C416(1.12); C196(0.96); C248(1.25)  LDD1595  [16]
 LDCM0392  CL121 HEK-293T C169(0.86); C416(1.02); C196(1.11); C248(0.92)  LDD1596  [16]
 LDCM0393  CL122 HEK-293T C169(1.10); C416(1.09); C196(1.06); C248(0.82)  LDD1597  [16]
 LDCM0394  CL123 HEK-293T C169(0.83); C416(0.95); C248(0.92); C212(1.13)  LDD1598  [16]
 LDCM0395  CL124 HEK-293T C416(1.07); C196(0.94); C248(1.15)  LDD1599  [16]
 LDCM0396  CL125 HEK-293T C169(1.06); C416(0.85); C196(0.90); C248(1.06)  LDD1600  [16]
 LDCM0397  CL126 HEK-293T C169(1.03); C416(1.00); C196(1.05); C248(0.95)  LDD1601  [16]
 LDCM0398  CL127 HEK-293T C169(1.06); C416(0.99); C248(0.98); C212(1.39)  LDD1602  [16]
 LDCM0399  CL128 HEK-293T C416(1.18); C196(0.94); C248(1.01)  LDD1603  [16]
 LDCM0400  CL13 HEK-293T C169(0.81); C416(1.05); C196(1.20); C248(1.00)  LDD1604  [16]
 LDCM0401  CL14 HEK-293T C169(1.07); C416(1.11); C196(0.94); C248(0.92)  LDD1605  [16]
 LDCM0402  CL15 HEK-293T C169(1.00); C416(0.88); C248(1.01); C212(0.95)  LDD1606  [16]
 LDCM0403  CL16 HEK-293T C416(1.21); C196(1.02); C248(1.14)  LDD1607  [16]
 LDCM0404  CL17 HEK-293T C169(0.91); C416(0.94); C248(1.08)  LDD1608  [16]
 LDCM0405  CL18 HEK-293T C416(0.93); C196(1.23); C248(1.03)  LDD1609  [16]
 LDCM0406  CL19 HEK-293T C169(1.09); C416(1.00); C248(1.05)  LDD1610  [16]
 LDCM0407  CL2 HEK-293T C169(0.96); C416(1.05); C196(1.11); C248(0.92)  LDD1611  [16]
 LDCM0408  CL20 HEK-293T C169(1.21); C416(0.92); C248(0.98); C212(0.57)  LDD1612  [16]
 LDCM0409  CL21 HEK-293T C169(0.94); C416(0.93); C248(1.08); C212(0.56)  LDD1613  [16]
 LDCM0410  CL22 HEK-293T C169(1.05); C416(0.83); C196(1.16); C248(1.18)  LDD1614  [16]
 LDCM0411  CL23 HEK-293T C169(1.10); C416(0.94); C248(0.98); C212(0.48)  LDD1615  [16]
 LDCM0412  CL24 HEK-293T C169(1.07); C416(0.88); C248(1.40); C212(0.44)  LDD1616  [16]
 LDCM0413  CL25 HEK-293T C169(1.10); C416(0.99); C196(0.94); C248(1.01)  LDD1617  [16]
 LDCM0414  CL26 HEK-293T C169(1.04); C416(1.05); C196(0.90); C248(0.83)  LDD1618  [16]
 LDCM0415  CL27 HEK-293T C169(0.97); C416(0.97); C248(0.88); C212(0.93)  LDD1619  [16]
 LDCM0416  CL28 HEK-293T C416(1.13); C196(0.95); C248(1.16)  LDD1620  [16]
 LDCM0417  CL29 HEK-293T C169(0.98); C416(1.01); C248(1.00)  LDD1621  [16]
 LDCM0418  CL3 HEK-293T C169(1.00); C416(0.88); C248(1.10); C212(1.11)  LDD1622  [16]
 LDCM0419  CL30 HEK-293T C416(0.99); C196(1.04); C248(0.98)  LDD1623  [16]
 LDCM0420  CL31 HEK-293T C169(1.05); C416(1.06); C248(0.91)  LDD1624  [16]
 LDCM0421  CL32 HEK-293T C169(0.98); C416(1.03); C248(1.09); C212(0.66)  LDD1625  [16]
 LDCM0422  CL33 HEK-293T C169(1.01); C416(0.89); C248(0.93); C212(0.76)  LDD1626  [16]
 LDCM0423  CL34 HEK-293T C169(0.87); C416(0.86); C196(1.00); C248(1.10)  LDD1627  [16]
 LDCM0424  CL35 HEK-293T C169(0.85); C416(1.07); C248(0.83); C212(0.44)  LDD1628  [16]
 LDCM0425  CL36 HEK-293T C169(0.93); C416(1.00); C248(1.11); C212(0.42)  LDD1629  [16]
 LDCM0426  CL37 HEK-293T C169(0.98); C416(1.08); C196(0.92); C248(0.91)  LDD1630  [16]
 LDCM0428  CL39 HEK-293T C169(0.96); C416(1.06); C248(0.97); C212(1.12)  LDD1632  [16]
 LDCM0429  CL4 HEK-293T C416(1.06); C196(0.86); C248(1.02)  LDD1633  [16]
 LDCM0430  CL40 HEK-293T C416(1.18); C196(1.06); C248(1.19)  LDD1634  [16]
 LDCM0431  CL41 HEK-293T C169(1.24); C416(1.00); C248(1.13)  LDD1635  [16]
 LDCM0432  CL42 HEK-293T C416(0.99); C196(1.04); C248(1.02)  LDD1636  [16]
 LDCM0433  CL43 HEK-293T C169(1.21); C416(1.02); C248(1.05)  LDD1637  [16]
 LDCM0434  CL44 HEK-293T C169(0.98); C416(0.92); C248(1.18); C212(0.63)  LDD1638  [16]
 LDCM0435  CL45 HEK-293T C169(1.00); C416(1.03); C248(1.02); C212(0.65)  LDD1639  [16]
 LDCM0436  CL46 HEK-293T C169(0.95); C416(1.01); C196(1.13); C248(1.19)  LDD1640  [16]
 LDCM0437  CL47 HEK-293T C169(1.07); C416(1.08); C248(1.08); C212(0.48)  LDD1641  [16]
 LDCM0438  CL48 HEK-293T C169(1.15); C416(0.92); C248(0.93); C212(0.47)  LDD1642  [16]
 LDCM0439  CL49 HEK-293T C169(1.05); C416(1.05); C196(1.01); C248(1.07)  LDD1643  [16]
 LDCM0440  CL5 HEK-293T C169(1.03); C416(0.97); C248(0.78)  LDD1644  [16]
 LDCM0441  CL50 HEK-293T C169(0.88); C416(0.88); C196(0.94); C248(0.97)  LDD1645  [16]
 LDCM0443  CL52 HEK-293T C416(1.22); C196(1.01); C248(1.15)  LDD1646  [16]
 LDCM0444  CL53 HEK-293T C169(1.09); C416(0.97); C248(0.97)  LDD1647  [16]
 LDCM0445  CL54 HEK-293T C416(0.85); C196(1.10); C248(0.89)  LDD1648  [16]
 LDCM0446  CL55 HEK-293T C169(1.05); C416(1.05); C248(0.99)  LDD1649  [16]
 LDCM0447  CL56 HEK-293T C169(1.04); C416(0.98); C248(0.87); C212(0.68)  LDD1650  [16]
 LDCM0448  CL57 HEK-293T C169(1.08); C416(0.95); C248(0.91); C212(0.63)  LDD1651  [16]
 LDCM0449  CL58 HEK-293T C169(0.97); C416(0.81); C196(1.14); C248(1.20)  LDD1652  [16]
 LDCM0450  CL59 HEK-293T C169(1.28); C416(0.96); C248(0.97); C212(0.55)  LDD1653  [16]
 LDCM0451  CL6 HEK-293T C416(0.87); C196(0.93); C248(0.93)  LDD1654  [16]
 LDCM0452  CL60 HEK-293T C169(1.04); C416(0.92); C248(1.05); C212(0.50)  LDD1655  [16]
 LDCM0453  CL61 HEK-293T C169(1.08); C416(0.95); C196(1.21); C248(0.93)  LDD1656  [16]
 LDCM0454  CL62 HEK-293T C169(1.14); C416(1.04); C196(1.00); C248(0.86)  LDD1657  [16]
 LDCM0455  CL63 HEK-293T C169(0.96); C416(0.93); C248(0.95); C212(1.08)  LDD1658  [16]
 LDCM0456  CL64 HEK-293T C416(1.11); C196(0.91); C248(1.30)  LDD1659  [16]
 LDCM0457  CL65 HEK-293T C169(1.03); C416(0.98); C248(0.82)  LDD1660  [16]
 LDCM0458  CL66 HEK-293T C416(0.95); C196(1.01); C248(1.10)  LDD1661  [16]
 LDCM0459  CL67 HEK-293T C169(1.07); C416(0.99); C248(1.09)  LDD1662  [16]
 LDCM0460  CL68 HEK-293T C169(1.37); C416(0.99); C248(1.04); C212(0.67)  LDD1663  [16]
 LDCM0461  CL69 HEK-293T C169(0.98); C416(1.00); C248(1.00); C212(0.64)  LDD1664  [16]
 LDCM0462  CL7 HEK-293T C169(1.12); C416(0.99); C248(0.93)  LDD1665  [16]
 LDCM0463  CL70 HEK-293T C169(1.03); C416(0.92); C196(1.15); C248(1.24)  LDD1666  [16]
 LDCM0464  CL71 HEK-293T C169(1.06); C416(1.00); C248(1.00); C212(0.56)  LDD1667  [16]
 LDCM0465  CL72 HEK-293T C169(1.10); C416(0.95); C248(1.38); C212(0.50)  LDD1668  [16]
 LDCM0466  CL73 HEK-293T C169(0.95); C416(0.96); C196(0.99); C248(0.93)  LDD1669  [16]
 LDCM0467  CL74 HEK-293T C169(1.01); C416(1.02); C196(1.02); C248(0.93)  LDD1670  [16]
 LDCM0469  CL76 HEK-293T C416(1.22); C196(1.03); C248(1.23)  LDD1672  [16]
 LDCM0470  CL77 HEK-293T C169(1.00); C416(0.98); C248(1.14)  LDD1673  [16]
 LDCM0471  CL78 HEK-293T C416(0.98); C196(1.22); C248(1.08)  LDD1674  [16]
 LDCM0472  CL79 HEK-293T C169(0.92); C416(1.05); C248(1.00)  LDD1675  [16]
 LDCM0473  CL8 HEK-293T C169(1.31); C416(0.65); C248(0.98); C212(0.81)  LDD1676  [16]
 LDCM0474  CL80 HEK-293T C169(1.24); C416(0.95); C248(1.00); C212(0.71)  LDD1677  [16]
 LDCM0475  CL81 HEK-293T C169(0.94); C416(1.05); C248(1.08); C212(0.63)  LDD1678  [16]
 LDCM0476  CL82 HEK-293T C169(0.97); C416(0.89); C196(1.08); C248(1.09)  LDD1679  [16]
 LDCM0477  CL83 HEK-293T C169(1.14); C416(0.91); C248(0.93); C212(0.60)  LDD1680  [16]
 LDCM0478  CL84 HEK-293T C169(0.90); C416(0.93); C248(1.04); C212(0.62)  LDD1681  [16]
 LDCM0479  CL85 HEK-293T C169(1.06); C416(0.96); C196(1.06); C248(1.16)  LDD1682  [16]
 LDCM0480  CL86 HEK-293T C169(1.19); C416(0.87); C196(1.11); C248(0.88)  LDD1683  [16]
 LDCM0481  CL87 HEK-293T C169(1.09); C416(1.08); C248(1.09); C212(1.62)  LDD1684  [16]
 LDCM0482  CL88 HEK-293T C416(1.16); C196(1.02); C248(1.21)  LDD1685  [16]
 LDCM0483  CL89 HEK-293T C169(0.90); C416(1.01); C248(1.01)  LDD1686  [16]
 LDCM0484  CL9 HEK-293T C169(1.03); C416(1.00); C248(1.06); C212(0.51)  LDD1687  [16]
 LDCM0485  CL90 HEK-293T C416(0.79); C196(0.95); C248(0.88)  LDD1688  [16]
 LDCM0486  CL91 HEK-293T C169(1.13); C416(0.96); C248(0.92)  LDD1689  [16]
 LDCM0487  CL92 HEK-293T C169(0.98); C416(0.85); C248(0.94); C212(0.90)  LDD1690  [16]
 LDCM0488  CL93 HEK-293T C169(0.90); C416(1.01); C248(0.97); C212(0.68)  LDD1691  [16]
 LDCM0489  CL94 HEK-293T C169(0.97); C416(0.92); C196(1.15); C248(1.29)  LDD1692  [16]
 LDCM0490  CL95 HEK-293T C169(0.91); C416(0.86); C248(0.81); C212(1.48)  LDD1693  [16]
 LDCM0491  CL96 HEK-293T C169(1.04); C416(0.93); C248(1.10); C212(1.43)  LDD1694  [16]
 LDCM0492  CL97 HEK-293T C169(0.97); C416(0.98); C196(0.91); C248(1.10)  LDD1695  [16]
 LDCM0493  CL98 HEK-293T C169(0.88); C416(0.96); C196(1.02); C248(1.11)  LDD1696  [16]
 LDCM0494  CL99 HEK-293T C169(1.00); C416(1.01); C248(0.99); C212(1.22)  LDD1697  [16]
 LDCM0495  E2913 HEK-293T C169(1.01); C416(0.88); C248(1.01); C212(1.12)  LDD1698  [16]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [4]
 LDCM0468  Fragment33 HEK-293T C169(1.03); C416(0.89); C248(0.96); C212(1.01)  LDD1671  [16]
 LDCM0427  Fragment51 HEK-293T C169(1.17); C416(1.03); C196(0.96); C248(0.87)  LDD1631  [16]
 LDCM0022  KB02 HEK-293T C416(0.99); C248(0.89)  LDD1492  [16]
 LDCM0023  KB03 HEK-293T C416(1.07); C248(1.05)  LDD1497  [16]
 LDCM0024  KB05 COLO792 C86(1.57)  LDD3310  [3]
 LDCM0109  NEM HeLa N.A.  LDD0223  [5]
 LDCM0019  Staurosporine Hep-G2 N.A.  LDD0083  [14]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMK2A) CAMK Ser/Thr protein kinase family Q9UQM7
Mitogen-activated protein kinase 1 (MAPK1) CMGC Ser/Thr protein kinase family P28482
Hepatocyte growth factor receptor (MET) Tyr protein kinase family P08581
Mast/stem cell growth factor receptor Kit (KIT) Tyr protein kinase family P10721
Epidermal growth factor receptor (EGFR) Tyr protein kinase family P00533
Receptor tyrosine-protein kinase erbB-2 (ERBB2) Tyr protein kinase family P04626
Receptor tyrosine-protein kinase erbB-3 (ERBB3) Tyr protein kinase family P21860
Receptor tyrosine-protein kinase erbB-4 (ERBB4) Tyr protein kinase family Q15303
Insulin receptor (INSR) Tyr protein kinase family P06213
Insulin-like growth factor 1 receptor (IGF1R) Tyr protein kinase family P08069
Tyrosine-protein phosphatase non-receptor type 12 (PTPN12) Protein-tyrosine phosphatase family Q05209
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Androgen receptor (AR) Nuclear hormone receptor family P10275
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2) CALCOCO family Q13137
GRB2-associated-binding protein 1 (GAB1) GAB family Q13480
Growth factor receptor-bound protein 2 (GRB2) GRB2/sem-5/DRK family P62993
Son of sevenless homolog 1 (SOS1) . Q07889

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
14 Comprehensive identification of staurosporine-binding kinases in the hepatocyte cell line HepG2 using Capture Compound Mass Spectrometry (CCMS). J Proteome Res. 2010 Feb 5;9(2):806-17. doi: 10.1021/pr9007333.
15 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
16 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402