Details of the Target

General Information of Target

Target ID LDTP02892
Target Name Transcription factor JunB (JUNB)
Gene Name JUNB
Gene ID 3726
Synonyms
Transcription factor JunB; Transcription factor AP-1 subunit JunB
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MCTKMEQPFYHDDSYTATGYGRAPGGLSLHDYKLLKPSLAVNLADPYRSLKAPGARGPGP
EGGGGGSYFSGQGSDTGASLKLASSELERLIVPNSNGVITTTPTPPGQYFYPRGGGSGGG
AGGAGGGVTEEQEGFADGFVKALDDLHKMNHVTPPNVSLGATGGPPAGPGGVYAGPEPPP
VYTNLSSYSPASASSGGAGAAVGTGSSYPTTTISYLPHAPPFAGGHPAQLGLGRGASTFK
EEPQTVPEARSRDATPPVSPINMEDQERIKVERKRLRNRLAATKCRKRKLERIARLEDKV
KTLKAENAGLSSTAGLLREQVAQLKQKVMTHVSNGCQLLLGVKGHAF
Target Bioclass
Transcription factor
Family
BZIP family, Jun subfamily
Subcellular location
Nucleus
Function
Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[GC]TCA-3'. Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to an AP-1 consensus sequence and its transcriptional activity.
Uniprot ID
P17275
Ensemble ID
ENST00000302754.6
HGNC ID
HGNC:6205

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
Probe 1
 Probe Info  		Y68(45.54)  LDD3495  [2]
EA-probe
 Probe Info  		N.A.  LDD0440  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [1]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
Transcription factor
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Basic leucine zipper transcriptional factor ATF-like (BATF) BZIP family Q16520
Basic leucine zipper transcriptional factor ATF-like 2 (BATF2) BZIP family Q8N1L9
Basic leucine zipper transcriptional factor ATF-like 3 (BATF3) BZIP family Q9NR55
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) BZIP family P18848
Cyclic AMP-dependent transcription factor ATF-7 (ATF7) BZIP family P17544
DNA damage-inducible transcript 3 protein (DDIT3) BZIP family P35638
Cyclic AMP-dependent transcription factor ATF-3 (ATF3) BZIP family P18847
Jun dimerization protein 2 (JDP2) BZIP family Q8WYK2
Fos-related antigen 1 (FOSL1) BZIP family P15407
Fos-related antigen 2 (FOSL2) BZIP family P15408
Protein c-Fos (FOS) BZIP family P01100
Protein FosB (FOSB) BZIP family P53539
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-dependent transcription factor ATF-2 (ATF2) BZIP family P15336
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
T-cell leukemia/lymphoma protein 1A (TCL1A) TCL1 family P56279
Uncharacterized protein ZSWIM9 (ZSWIM9) . Q86XI8

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.